SIMILAR PATTERNS OF AMINO ACIDS FOR 5FA8_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A
ABRIN-A

(Abrus
precatorius;
Abrus
precatorius) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 PRO A 214
GLY B 139
ILE B  18
PHE A 213
LEU A 232
 None
 1.16A 5fa8A-1abrA:
undetectable		 5fa8A-1abrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 GLY A  18
GLY A  20
ILE A  27
ILE A  43
ASN A  44
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
None
NAI  A 302 (-4.0A)
None
 0.78A 5fa8A-1ahiA:
7.1		 5fa8A-1ahiA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 GLY A 237
GLY A 242
ILE A 293
PHE A 499
LEU A 459
 None
None
SF4  A 608 ( 3.5A)
None
None
 0.98A 5fa8A-1aorA:
undetectable		 5fa8A-1aorA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3n AGGLUTININ

(Helianthus
tuberosus) 		PF01419
(Jacalin) 		5 PRO A 109
GLY A  84
ILE A  41
PHE A 130
PHE A 110
 None
 1.03A 5fa8A-1c3nA:
undetectable		 5fa8A-1c3nA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		5 GLY A  63
GLY A  65
ILE A  69
ILE A  85
ASN A  86
 None
 0.39A 5fa8A-1dusA:
5.6		 5fa8A-1dusA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE

(Lactobacillus
pentosus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 191
GLY A 288
ILE A 285
ILE A 189
LEU A 311
 None
 0.95A 5fa8A-1ez4A:
6.6		 5fa8A-1ez4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuk EUKARYOTIC
INITIATION FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		5 ILE A 382
ILE A 264
PHE A 362
PHE A 236
LEU A 392
 None
 1.08A 5fa8A-1fukA:
3.4		 5fa8A-1fukA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		5 GLY A 386
GLY A 366
ILE A 388
PHE A 436
LEU A 371
 None
 1.11A 5fa8A-1gxnA:
undetectable		 5fa8A-1gxnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus;
Equus caballus) 		PF00079
(Serpin)
PF00079
(Serpin) 		5 PRO B 369
GLY B 386
ILE A 252
ASN A  42
PHE B 388
 None
 1.13A 5fa8A-1hleB:
undetectable		 5fa8A-1hleB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus) 		PF00160
(Pro_isomerase)
PF13176
(TPR_7) 		5 GLY A 129
ILE A  98
ASN A 122
PHE A  48
LEU A 118
 None
 1.06A 5fa8A-1iipA:
undetectable		 5fa8A-1iipA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ist CYCLOPHILIN A

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase) 		5 GLY A 107
ILE A  76
ASN A 100
PHE A  34
LEU A  96
 None
 1.01A 5fa8A-1istA:
undetectable		 5fa8A-1istA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLY A 469
ILE A 450
ASN A 165
ARG A 168
ASN A 190
 None
 1.14A 5fa8A-1lamA:
undetectable		 5fa8A-1lamA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		5 GLY A  25
GLY A  21
ILE A 273
ILE A 230
LEU A  40
 None
FAD  A 652 ( 4.3A)
FAD  A 652 (-3.6A)
None
None
 1.14A 5fa8A-1o5wA:
3.4		 5fa8A-1o5wA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q67 DECAPPING PROTEIN
INVOLVED IN MRNA
DEGRADATION-DCP1P

(Saccharomyces
cerevisiae) 		PF06058
(DCP1) 		5 GLY A 141
ILE A 218
ARG A  70
PHE A 153
LEU A 196
 None
 1.05A 5fa8A-1q67A:
undetectable		 5fa8A-1q67A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		5 GLY A 129
ILE A  24
ILE A 122
ASN A 125
LEU A 394
 None
 1.13A 5fa8A-1u2xA:
undetectable		 5fa8A-1u2xA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		5 GLY A 399
GLY A 401
ILE A 423
PHE A 460
LEU A 482
 SAH  A 801 (-3.1A)
SAH  A 801 ( 4.2A)
SAH  A 801 (-3.7A)
SAH  A 801 (-3.5A)
None
 0.76A 5fa8A-1u2zA:
13.5		 5fa8A-1u2zA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaq CYTOSINE DEAMINASE

(Saccharomyces
cerevisiae) 		PF00383
(dCMP_cyt_deam_1) 		5 GLY A  49
GLY A  34
ILE A  17
ASN A  51
LEU A  68
 None
None
None
DUC  A 300 (-3.9A)
None
 0.98A 5fa8A-1uaqA:
undetectable		 5fa8A-1uaqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Pyrobaculum
aerophilum) 		PF01791
(DeoC) 		5 GLY A 150
GLY A 191
ARG A 194
ILE A 119
LEU A   9
 None
 1.14A 5fa8A-1vcvA:
undetectable		 5fa8A-1vcvA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PRO A  29
GLY A  76
GLY A  31
ILE A  33
ARG A  30
 None
 1.14A 5fa8A-1vj0A:
8.4		 5fa8A-1vj0A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi9 PUTATIVE
TRANSAMINASE

(Pyrococcus
furiosus) 		PF00155
(Aminotran_1_2) 		5 GLY A 180
ARG A 305
ILE A 329
ILE A 173
ASN A 174
 None
None
None
PLP  A 501 (-4.2A)
None
 1.15A 5fa8A-1xi9A:
3.5		 5fa8A-1xi9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmf PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 GLY A 245
ILE A 214
ASN A 238
PHE A 172
LEU A 234
 None
 0.99A 5fa8A-1zmfA:
undetectable		 5fa8A-1zmfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		5 GLY A 239
GLY A 190
ILE A 252
ASN A 199
LEU A 233
 None
 1.13A 5fa8A-2ay9A:
undetectable		 5fa8A-2ay9A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfe ALLERGEN

(Malassezia
sympodialis) 		PF00160
(Pro_isomerase) 		5 GLY A 107
ILE A  76
ASN A 100
PHE A  34
LEU A  96
 None
 1.02A 5fa8A-2cfeA:
undetectable		 5fa8A-2cfeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Schistosoma
mansoni) 		PF00160
(Pro_isomerase) 		5 GLY A 116
ILE A  85
ASN A 109
PHE A  43
LEU A 105
 None
 1.12A 5fa8A-2cmtA:
undetectable		 5fa8A-2cmtA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		5 GLY A  37
ILE A  11
ASN A  22
PHE A  25
LEU A 123
 None
None
NAG  A1001 (-2.0A)
None
None
 1.05A 5fa8A-2e47A:
undetectable		 5fa8A-2e47A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej5 ENOYL-COA HYDRATASE
SUBUNIT II

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		5 PRO A 131
GLY A  65
ASN A  34
PHE A  29
LEU A 116
 None
 1.17A 5fa8A-2ej5A:
undetectable		 5fa8A-2ej5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		5 GLY A 226
GLY A 222
ARG A 221
ILE A 284
PHE A 230
 None
None
GAD  A 404 (-4.0A)
None
None
 1.09A 5fa8A-2fv0A:
undetectable		 5fa8A-2fv0A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		5 GLY A  79
GLY A  81
ILE A 107
PHE A  78
LEU A  25
 None
 0.91A 5fa8A-2hcuA:
undetectable		 5fa8A-2hcuA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he9 NK-TUMOR RECOGNITION
PROTEIN

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 GLY A 120
ILE A  89
ASN A 113
PHE A  39
LEU A 109
 None
 1.06A 5fa8A-2he9A:
undetectable		 5fa8A-2he9A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Leishmania
major) 		PF00160
(Pro_isomerase) 		5 GLY A 119
ILE A  85
ASN A 112
PHE A  36
LEU A 108
 None
 1.07A 5fa8A-2hqjA:
undetectable		 5fa8A-2hqjA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00156
(Pribosyltran) 		5 GLY A  65
ARG A  98
ILE A  92
ASN A 136
PHE A  99
 None
 1.12A 5fa8A-2jbhA:
undetectable		 5fa8A-2jbhA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jyz CG7054-PA

(Drosophila
melanogaster) 		PF01161
(PBP) 		5 GLY A 138
ILE A 177
ARG A 139
ASN A 174
PHE A 142
 None
 1.11A 5fa8A-2jyzA:
undetectable		 5fa8A-2jyzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzr UBIQUITIN
THIOESTERASE OTU1

(Mus musculus) 		no annotation 5 GLY A  62
ARG A  22
ILE A  59
ARG A  20
LEU A  17
 None
 1.04A 5fa8A-2kzrA:
undetectable		 5fa8A-2kzrA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 GLY A 453
ILE A 483
ILE A 432
ASN A 436
LEU A 353
 None
 1.17A 5fa8A-2nrxA:
undetectable		 5fa8A-2nrxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Cryptosporidium
parvum) 		PF00160
(Pro_isomerase) 		5 GLY A 132
ILE A 101
ASN A 125
PHE A  52
LEU A 121
 None
 0.98A 5fa8A-2poyA:
undetectable		 5fa8A-2poyA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 GLY A 230
GLY A 228
ILE A 532
ILE A 235
PHE A 100
 FAD  A1535 (-3.4A)
None
None
FAD  A1535 (-3.8A)
None
 1.11A 5fa8A-2qpmA:
undetectable		 5fa8A-2qpmA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 PRO A  37
GLY A  41
GLY A  53
PHE A  42
PHE A 122
 None
 1.12A 5fa8A-2qxlA:
undetectable		 5fa8A-2qxlA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uur COLLAGEN ALPHA-1(IX)
CHAIN

(Homo sapiens) 		no annotation 5 ILE A  74
ILE A 121
ASN A 106
PHE A  72
LEU A  66
 None
 1.16A 5fa8A-2uurA:
undetectable		 5fa8A-2uurA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		5 GLY A 693
ILE A 612
ILE A 597
PHE A 593
LEU A 719
 None
 1.06A 5fa8A-2vsaA:
undetectable		 5fa8A-2vsaA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 GLY A 121
ILE A  90
ASN A 114
PHE A  40
LEU A 110
 None
None
MG  A1002 ( 4.7A)
None
None
 0.98A 5fa8A-2wfiA:
undetectable		 5fa8A-2wfiA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 GLY B 109
ILE B  78
ASN B 102
PHE B  36
LEU B  98
 None
None
ALY  B 125 ( 3.4A)
None
None
 1.02A 5fa8A-2x25B:
undetectable		 5fa8A-2x25B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 ILE A 468
ILE A 221
ASN A 189
ARG A 228
LEU A 650
 None
None
None
B12  A 800 (-3.8A)
None
 1.08A 5fa8A-2xijA:
2.3		 5fa8A-2xijA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF03358
(FMN_red) 		5 GLY A  25
GLY A  27
ILE A 187
ARG A 181
LEU A  20
 None
None
None
SO4  A 505 ( 2.9A)
None
 0.99A 5fa8A-2zkiA:
undetectable		 5fa8A-2zkiA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 GLY A 892
ILE A 638
ILE A1198
ASN A1204
PHE A 642
 None
 1.08A 5fa8A-2zxqA:
undetectable		 5fa8A-2zxqA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		5 PRO A 299
GLY A 302
GLY A 166
ILE A 194
ASN A 160
 None
 1.10A 5fa8A-3ffhA:
undetectable		 5fa8A-3ffhA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		5 GLY A 626
ILE A 665
ILE A 620
ASN A 621
ASN A 630
 None
 1.03A 5fa8A-3hvdA:
undetectable		 5fa8A-3hvdA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		5 PRO A 125
GLY A 179
GLY A 181
ILE A 673
ASN A 243
 None
 1.06A 5fa8A-3i5gA:
2.7		 5fa8A-3i5gA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8n UNCHARACTERIZED
PROTEIN VP2912

(Vibrio
parahaemolyticus) 		PF00571
(CBS) 		5 PRO A 265
GLY A 260
ILE A 212
PHE A 215
PHE A 240
 None
 1.04A 5fa8A-3i8nA:
undetectable		 5fa8A-3i8nA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLY A 222
GLY A 218
ILE A 251
ILE A 283
LEU A 423
 None
None
None
EDO  A  23 ( 4.7A)
None
 1.14A 5fa8A-3ihvA:
undetectable		 5fa8A-3ihvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ino PROTECTIVE ANTIGEN
PA-63

(Bacillus
anthracis) 		no annotation 5 GLY A 626
ILE A 665
ILE A 620
ASN A 621
ASN A 630
 None
 1.14A 5fa8A-3inoA:
undetectable		 5fa8A-3inoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktn CARBOHYDRATE KINASE,
PFKB FAMILY

(Enterococcus
faecalis) 		PF00294
(PfkB) 		5 GLY A  33
GLY A  35
ILE A 315
ILE A 136
LEU A  55
 None
None
None
SO4  A 401 ( 4.4A)
None
 1.08A 5fa8A-3ktnA:
3.5		 5fa8A-3ktnA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		5 PRO A  14
GLY A 231
ILE A 226
ILE A  23
ASN A  22
 None
 1.08A 5fa8A-3ncyA:
undetectable		 5fa8A-3ncyA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7t CYCLOPHILIN A

(Moniliophthora
perniciosa) 		PF00160
(Pro_isomerase) 		5 GLY A 107
ILE A  76
ASN A 100
PHE A  34
LEU A  96
 None
 1.04A 5fa8A-3o7tA:
undetectable		 5fa8A-3o7tA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlj SHORT CHAIN
DEHYDROGENASE

(Mycobacterium
avium) 		PF00106
(adh_short) 		5 GLY A  13
GLY A  15
ARG A  20
ILE A  38
ASN A  73
 None
 1.14A 5fa8A-3qljA:
6.5		 5fa8A-3qljA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqz METALLOPHOSPHOESTERA
SE

(Sphaerobacter
thermophilus) 		PF12850
(Metallophos_2) 		5 GLY A 115
ILE A 182
ILE A 121
ASN A 103
ASN A  61
 None
None
None
None
ZN  A 302 (-3.3A)
 1.18A 5fa8A-3rqzA:
undetectable		 5fa8A-3rqzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm3 SAM-DEPENDENT
METHYLTRANSFERASES

(Methanosarcina
mazei) 		PF08241
(Methyltransf_11) 		5 GLY A  38
GLY A  40
ILE A  44
ILE A  60
ASN A  61
 None
 0.75A 5fa8A-3sm3A:
13.2		 5fa8A-3sm3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm3 SAM-DEPENDENT
METHYLTRANSFERASES

(Methanosarcina
mazei) 		PF08241
(Methyltransf_11) 		5 GLY A  38
GLY A  40
ILE A  60
ASN A  61
ASN A  91
 None
 0.92A 5fa8A-3sm3A:
13.2		 5fa8A-3sm3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		5 GLY A 626
ILE A 665
ILE A 620
ASN A 621
ASN A 630
 None
 1.07A 5fa8A-3texA:
undetectable		 5fa8A-3texA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA

(Streptomyces
lividans) 		PF00266
(Aminotran_5) 		5 PRO A 204
GLY A 208
GLY A 206
ILE A 248
ASN A  73
 None
None
None
None
PLP  A 400 ( 4.8A)
 1.07A 5fa8A-3vaxA:
undetectable		 5fa8A-3vaxA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 PRO A 305
GLY A 342
ARG A 306
ILE A 399
ILE A 345
 None
 1.13A 5fa8A-3vm7A:
undetectable		 5fa8A-3vm7A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 GLY A 271
GLY A 287
ILE A 503
ASN A 496
LEU A 526
 None
GOL  A1010 (-3.5A)
None
None
None
 1.04A 5fa8A-3welA:
undetectable		 5fa8A-3welA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A  95
GLY A  93
ILE A  88
ILE A 361
ASN A 320
 None
 1.16A 5fa8A-4c2kA:
undetectable		 5fa8A-4c2kA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A  95
GLY A 355
ILE A  88
ASN A  89
ASN A 101
 None
 1.06A 5fa8A-4c2kA:
undetectable		 5fa8A-4c2kA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 PRO A  73
GLY A  93
GLY A  91
ILE A 331
ASN A  97
 None
MLI  A 503 (-3.6A)
None
None
None
 1.08A 5fa8A-4dwqA:
undetectable		 5fa8A-4dwqA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Triticum
aestivum) 		PF00160
(Pro_isomerase) 		5 GLY A 116
ILE A  85
ASN A 109
PHE A  36
LEU A 105
 None
 1.13A 5fa8A-4e1qA:
undetectable		 5fa8A-4e1qA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyv PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Serendipita
indica) 		PF00160
(Pro_isomerase) 		5 GLY A 109
ILE A  78
ASN A 102
PHE A  36
LEU A  98
 None
 1.00A 5fa8A-4eyvA:
undetectable		 5fa8A-4eyvA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME

(unidentified) 		PF12146
(Hydrolase_4) 		5 GLY A 128
ILE A 204
ILE A 149
ASN A 150
PHE A  58
 None
 1.13A 5fa8A-4fblA:
2.5		 5fa8A-4fblA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Triticum
aestivum) 		PF00160
(Pro_isomerase) 		5 GLY A 116
ILE A  85
ASN A 109
PHE A  36
LEU A 105
 None
 1.08A 5fa8A-4hy7A:
undetectable		 5fa8A-4hy7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		5 GLY A  38
GLY A  43
ILE A  66
ILE A 289
LEU A  58
 FAD  A 501 (-3.2A)
None
None
None
None
 1.09A 5fa8A-4i59A:
undetectable		 5fa8A-4i59A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5a PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
F, MITOCHONDRIAL

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 GLY X 151
ILE X 120
ASN X 144
PHE X  78
LEU X 140
 67Z  X 301 (-3.8A)
None
None
None
None
 1.09A 5fa8A-4j5aX:
undetectable		 5fa8A-4j5aX:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		6 GLY A  13
GLY A  15
ILE A  21
ILE A  37
ASN A  38
ASN A  56
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.0A)
None
ADP  A 601 (-3.9A)
None
ADP  A 601 (-3.8A)
 1.47A 5fa8A-4j91A:
7.0		 5fa8A-4j91A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Brugia malayi) 		PF00160
(Pro_isomerase) 		5 GLY A 116
ILE A  85
ASN A 109
PHE A  36
LEU A 105
 None
 1.05A 5fa8A-4jcpA:
undetectable		 5fa8A-4jcpA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Citrus sinensis) 		PF00160
(Pro_isomerase) 		5 GLY A 116
ILE A  85
ASN A 109
PHE A  36
LEU A 105
 None
 1.06A 5fa8A-4jjmA:
undetectable		 5fa8A-4jjmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 GLY A 673
GLY A 675
ILE A 627
ILE A 376
LEU A 646
 None
 0.92A 5fa8A-4o9xA:
undetectable		 5fa8A-4o9xA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01209
(Ubie_methyltran) 		5 GLY A 121
ILE A 125
ILE A 149
ASN A 150
ASN A 179
 None
None
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.7A)
 0.99A 5fa8A-4obwA:
14.4		 5fa8A-4obwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		5 GLY A 329
ILE A 310
ILE A 462
ASN A 466
PHE A 465
 None
 1.05A 5fa8A-4oenA:
undetectable		 5fa8A-4oenA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		5 GLY A 187
GLY A 185
ILE A 233
ASN A  66
LEU A  80
 None
EDO  A 407 (-3.6A)
None
None
None
 1.16A 5fa8A-4ovyA:
undetectable		 5fa8A-4ovyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8f VACUOLAR
AMINOPEPTIDASE 1

(Saccharomyces
cerevisiae) 		PF02127
(Peptidase_M18) 		5 GLY A 447
GLY A 449
ILE A 269
PHE A  12
LEU A 253
 None
 1.13A 5fa8A-4r8fA:
undetectable		 5fa8A-4r8fA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		5 PRO A 204
GLY A 199
ARG A 252
PHE A 197
LEU A 249
 None
 1.07A 5fa8A-4roaA:
undetectable		 5fa8A-4roaA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1j PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Leishmania
donovani) 		PF00160
(Pro_isomerase) 		5 GLY A 131
ILE A 101
ASN A 124
PHE A  59
LEU A 120
 None
 1.12A 5fa8A-4s1jA:
undetectable		 5fa8A-4s1jA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		5 GLY A 213
GLY A 211
ILE A  57
ASN A 207
ASN A 151
 None
None
None
C  C  29 ( 3.1A)
A  C  26 ( 4.1A)
 1.11A 5fa8A-4z7lA:
undetectable		 5fa8A-4z7lA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bxy RNA
METHYLTRANSFERASE

(Salinibacter
ruber) 		PF13847
(Methyltransf_31) 		6 PRO A   6
GLY A  31
GLY A  33
ARG A  36
ILE A  37
ILE A  54
 SAH  A 201 (-4.4A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.4A)
None
None
SAH  A 201 (-3.9A)
 0.22A 5fa8A-5bxyA:
26.8		 5fa8A-5bxyA:
46.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE

(Sulfolobus
islandicus) 		PF13847
(Methyltransf_31) 		5 GLY A  36
ILE A  60
ASN A  87
PHE A  88
LEU A 104
 SAH  A 201 (-3.0A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.7A)
SAH  A 201 (-3.6A)
None
 1.15A 5fa8A-5fadA:
24.4		 5fa8A-5fadA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE

(Sulfolobus
islandicus) 		PF13847
(Methyltransf_31) 		11 PRO A  11
GLY A  36
GLY A  38
ARG A  41
ILE A  42
ILE A  60
ASN A  61
ARG A  64
ASN A  87
PHE A  88
PHE A 102
 SAH  A 201 (-4.5A)
SAH  A 201 (-3.0A)
SAH  A 201 (-3.5A)
None
None
SAH  A 201 (-3.8A)
None
None
SAH  A 201 (-3.7A)
SAH  A 201 (-3.6A)
SAH  A 201 (-4.9A)
 0.48A 5fa8A-5fadA:
24.4		 5fa8A-5fadA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijj SPX DOMAIN

(Chaetomium
thermophilum) 		PF03105
(SPX) 		5 GLY A 116
ILE A 118
ARG A 120
PHE A 115
LEU A  55
 None
 1.14A 5fa8A-5ijjA:
undetectable		 5fa8A-5ijjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 GLY B 338
GLY B 332
ILE B 328
ARG B 333
LEU B 242
 None
 1.18A 5fa8A-5ivlB:
2.1		 5fa8A-5ivlB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 166
ILE A 184
ASN A 172
PHE A 231
LEU A 235
 None
 1.13A 5fa8A-5j0aA:
undetectable		 5fa8A-5j0aA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 GLY A  13
GLY A  16
ILE A  18
ASN A  39
PHE A  92
 NAD  A 301 (-3.4A)
NAD  A 301 (-4.2A)
NAD  A 301 (-3.8A)
None
ACT  A 304 ( 4.0A)
 0.98A 5fa8A-5jy1A:
5.9		 5fa8A-5jy1A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 GLY A  19
GLY A  21
ILE A 223
ILE A  35
ARG A  24
 None
 1.10A 5fa8A-5jy1A:
5.9		 5fa8A-5jy1A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 GLY A 108
GLY A 105
ILE A 424
ILE A  77
LEU A  64
 None
 1.17A 5fa8A-5k3jA:
undetectable		 5fa8A-5k3jA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		5 GLY A 379
GLY A 375
ILE A 148
PHE A 373
LEU A 284
 None
 1.10A 5fa8A-5mrwA:
undetectable		 5fa8A-5mrwA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08638
(Med14)
PF10156
(Med17) 		5 PRO A 443
GLY W 322
GLY W 325
ILE W 429
LEU A 450
 None
 1.18A 5fa8A-5n9jA:
undetectable		 5fa8A-5n9jA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		5 PRO A 485
GLY A 128
GLY A 131
ARG A 489
ARG A 134
 None
 1.10A 5fa8A-5uaoA:
2.7		 5fa8A-5uaoA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6

(Saccharomyces
cerevisiae) 		PF10214
(Rrn6) 		5 PRO O 330
GLY O 327
ILE O 318
ARG O 339
LEU O 312
 None
 1.02A 5fa8A-5w5yO:
undetectable		 5fa8A-5w5yO:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yba PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trichomonas
vaginalis) 		no annotation 5 GLY A 117
ILE A  86
ASN A 110
PHE A  37
LEU A 106
 None
 1.06A 5fa8A-5ybaA:
undetectable		 5fa8A-5ybaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0i KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		no annotation 5 PRO K 287
GLY K 371
GLY K 373
ILE K 587
ASN K 484
 None
 1.14A 5fa8A-6b0iK:
undetectable		 5fa8A-6b0iK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 5 ILE A 425
ILE A 381
ASN A 382
ARG A 383
PHE A 418
 None
 1.13A 5fa8A-6b0tA:
undetectable		 5fa8A-6b0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus) 		no annotation 5 GLY H 342
GLY H 323
ILE H 320
ILE H 338
LEU H 496
 None
 1.14A 5fa8A-6cfwH:
undetectable		 5fa8A-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 GLY A  14
GLY A  16
ILE A  46
PHE A 302
LEU A  98
 None
 1.13A 5fa8A-6e85A:
undetectable		 5fa8A-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 5 GLY A 187
GLY A 185
ILE A 404
ASN A 339
PHE A 188
 None
FAD  A 601 (-3.5A)
None
None
None
 1.17A 5fa8A-6eo5A:
undetectable		 5fa8A-6eo5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		3 THR A 182
ASP A  89
GLU A 161
 None
 0.79A 5fa8A-1dppA:
undetectable		 5fa8A-1dppA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 THR A 295
ASP A 524
GLU A 519
 None
 0.74A 5fa8A-1e6vA:
0.0		 5fa8A-1e6vA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 THR A 102
ASP A  25
GLU A  18
 SAH  A 900 (-4.0A)
None
None
 0.78A 5fa8A-1kpiA:
13.5		 5fa8A-1kpiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 THR A 893
ASP A 259
GLU A 235
 MGD  A1019 (-3.6A)
MGD  A1019 (-3.0A)
None
 0.77A 5fa8A-1kqfA:
2.4		 5fa8A-1kqfA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF04045
(P34-Arc) 		3 THR D 246
ASP D  39
GLU D 150
 None
 0.84A 5fa8A-1u2vD:
undetectable		 5fa8A-1u2vD:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		3 THR A  96
ASP A 161
GLU A 157
 None
 0.77A 5fa8A-1wmrA:
0.0		 5fa8A-1wmrA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		3 THR A  30
ASP A  55
GLU A  79
 SAH  A1001 (-4.0A)
SAH  A1001 ( 4.5A)
SAH  A1001 (-2.8A)
 0.65A 5fa8A-1wy7A:
16.4		 5fa8A-1wy7A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcv DIPHTHERIA TOXIN
REPRESSOR MUTANT

(Corynebacterium
diphtheriae) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 THR A  14
ASP A 102
GLU A  83
 None
NI  A 252 (-3.0A)
None
 0.82A 5fa8A-1xcvA:
undetectable		 5fa8A-1xcvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		3 THR A 303
ASP A 274
GLU A 272
 None
 0.68A 5fa8A-1ypxA:
1.0		 5fa8A-1ypxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a24 ENDOTHELIAL PAS
DOMAIN PROTEIN 1

(Homo sapiens) 		PF08447
(PAS_3) 		3 THR A  19
ASP A  15
GLU A  43
 None
 0.66A 5fa8A-2a24A:
undetectable		 5fa8A-2a24A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 THR L  59
ASP L  82
GLU L  39
 None
 0.62A 5fa8A-2d7tL:
undetectable		 5fa8A-2d7tL:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		3 THR A 294
ASP A 250
GLU A 209
 None
 0.68A 5fa8A-2etvA:
undetectable		 5fa8A-2etvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		3 THR A 143
ASP A 176
GLU A 197
 None
 0.75A 5fa8A-2fefA:
undetectable		 5fa8A-2fefA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 THR A 173
ASP A 167
GLU A 230
 None
None
ZN  A 500 ( 4.2A)
 0.81A 5fa8A-2fpqA:
undetectable		 5fa8A-2fpqA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gxf HYPOTHETICAL PROTEIN
YYBH

(Bacillus
subtilis) 		PF13474
(SnoaL_3) 		3 THR A 103
ASP A 125
GLU A  99
 None
 0.84A 5fa8A-2gxfA:
undetectable		 5fa8A-2gxfA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG

(Escherichia
coli) 		PF13098
(Thioredoxin_2) 		3 THR A 145
ASP A 106
GLU A 189
 None
 0.57A 5fa8A-2h0iA:
undetectable		 5fa8A-2h0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i50 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 16

(Homo sapiens) 		PF02148
(zf-UBP) 		3 THR A  80
ASP A  33
GLU A  71
 None
 0.65A 5fa8A-2i50A:
undetectable		 5fa8A-2i50A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 THR A 168
ASP A 171
GLU A 175
 None
 0.82A 5fa8A-2iopA:
undetectable		 5fa8A-2iopA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 THR A 394
ASP A 434
GLU A 475
 None
 0.77A 5fa8A-2iukA:
undetectable		 5fa8A-2iukA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 THR A 358
ASP A 275
GLU A 267
 None
None
ZN  A1291 (-2.3A)
 0.84A 5fa8A-2np0A:
undetectable		 5fa8A-2np0A:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 THR A 432
ASP A  30
GLU A  36
 None
CA  A7001 (-3.3A)
None
 0.83A 5fa8A-2pwhA:
undetectable		 5fa8A-2pwhA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkw NEURAL CELL ADHESION
MOLECULE 1,140 KDA
ISOFORM

(Homo sapiens) 		PF00041
(fn3) 		3 THR A 595
ASP A 625
GLU A 600
 None
 0.85A 5fa8A-2vkwA:
undetectable		 5fa8A-2vkwA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xly CLOQ

(Streptomyces
roseochromogenus) 		PF11468
(PTase_Orf2) 		3 THR A  51
ASP A 260
GLU A 290
 None
 0.79A 5fa8A-2xlyA:
undetectable		 5fa8A-2xlyA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 THR B 151
ASP B 173
GLU B 216
 None
 0.78A 5fa8A-2y7cB:
11.5		 5fa8A-2y7cB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 THR A  88
ASP A  99
GLU A 117
 None
 0.56A 5fa8A-2z1aA:
undetectable		 5fa8A-2z1aA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		PF03717
(PBP_dimer)
PF00905
(Transpeptidase) 		3 THR A 159
ASP B 313
GLU A  89
 None
 0.71A 5fa8A-2z2mA:
undetectable		 5fa8A-2z2mA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus) 		PF03372
(Exo_endo_phos) 		3 THR A 203
ASP A 168
GLU A  39
 CA  A 281 (-3.9A)
None
None
 0.78A 5fa8A-3dniA:
1.6		 5fa8A-3dniA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)

(Geobacter
metallireducens) 		no annotation 3 THR A 232
ASP A 254
GLU A 279
 None
 0.57A 5fa8A-3e05A:
17.6		 5fa8A-3e05A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F
FRAGMENT OF
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 2

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF00957
(Synaptobrevin) 		3 THR A 243
ASP B  57
GLU B  55
 None
 0.81A 5fa8A-3fiiA:
undetectable		 5fa8A-3fiiA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE
ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		3 THR B 133
ASP A 115
GLU A  42
 None
 0.85A 5fa8A-3gyxB:
undetectable		 5fa8A-3gyxB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 THR A 189
ASP A 250
GLU A 434
 None
 0.80A 5fa8A-3i04A:
undetectable		 5fa8A-3i04A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		3 THR A   8
ASP A 166
GLU A  19
 None
MG  A 290 (-2.6A)
MG  A 291 (-2.6A)
 0.78A 5fa8A-3k4zA:
undetectable		 5fa8A-3k4zA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 THR A 228
ASP A 249
GLU A 289
 None
 0.86A 5fa8A-3khkA:
undetectable		 5fa8A-3khkA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 THR A 201
ASP A 227
GLU A 255
 None
 0.44A 5fa8A-3lkdA:
11.7		 5fa8A-3lkdA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		3 THR A 206
ASP A 113
GLU A 185
 None
 0.82A 5fa8A-3m8uA:
undetectable		 5fa8A-3m8uA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		3 THR A 540
ASP A 630
GLU A 625
 None
 0.66A 5fa8A-3mc2A:
undetectable		 5fa8A-3mc2A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1

(Homo sapiens) 		PF08585
(RMI1_N) 		3 THR A 140
ASP A  60
GLU A 200
 None
 0.79A 5fa8A-3nbiA:
undetectable		 5fa8A-3nbiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njr PRECORRIN-6Y
METHYLASE

(Rhodobacter
capsulatus) 		no annotation 3 THR A  18
ASP A  40
GLU A  63
 SAH  A 300 (-3.8A)
SAH  A 300 ( 4.8A)
SAH  A 300 (-2.6A)
 0.74A 5fa8A-3njrA:
18.1		 5fa8A-3njrA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nua PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Clostridium
perfringens) 		PF01259
(SAICAR_synt) 		3 THR A  34
ASP A 126
GLU A  91
 CIT  A 243 (-3.9A)
None
AMP  A 242 (-4.2A)
 0.84A 5fa8A-3nuaA:
undetectable		 5fa8A-3nuaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocm PUTATIVE MEMBRANE
PROTEIN

(Bordetella
parapertussis) 		PF00571
(CBS) 		3 THR A 443
ASP A 457
GLU A 454
 ADP  A 470 (-3.0A)
ADP  A 470 (-3.5A)
MG  A   7 ( 4.1A)
 0.86A 5fa8A-3ocmA:
undetectable		 5fa8A-3ocmA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p30 1281 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR L 163
ASP L  85
GLU L  83
 None
 0.85A 5fa8A-3p30L:
undetectable		 5fa8A-3p30L:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		3 THR A1279
ASP A1275
GLU A1248
 None
 0.81A 5fa8A-3pvlA:
undetectable		 5fa8A-3pvlA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 THR A 247
ASP A 135
GLU A 110
 None
 0.77A 5fa8A-3q9oA:
undetectable		 5fa8A-3q9oA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		3 THR A  61
ASP A 162
GLU A 118
 None
 0.75A 5fa8A-3rjuA:
undetectable		 5fa8A-3rjuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H

(Escherichia
coli) 		PF01795
(Methyltransf_5) 		3 THR A 178
ASP A 121
GLU A 185
 None
 0.82A 5fa8A-3tkaA:
13.7		 5fa8A-3tkaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpa HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		3 THR A 189
ASP A  96
GLU A 168
 None
 0.85A 5fa8A-3tpaA:
undetectable		 5fa8A-3tpaA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		3 THR A  53
ASP A 193
GLU A 197
 None
 0.76A 5fa8A-3ubdA:
undetectable		 5fa8A-3ubdA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 THR A 201
ASP A 223
GLU A 261
 None
 0.76A 5fa8A-3ufbA:
11.7		 5fa8A-3ufbA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 THR A  99
ASP A 110
GLU A 128
 None
 0.62A 5fa8A-3zu0A:
undetectable		 5fa8A-3zu0A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		3 THR A 335
ASP A 323
GLU A 330
 None
 0.81A 5fa8A-4a3uA:
undetectable		 5fa8A-4a3uA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 3 THR A 337
ASP A 414
GLU A 418
 None
 0.84A 5fa8A-4bb9A:
undetectable		 5fa8A-4bb9A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 THR A 404
ASP A 475
GLU A 460
 None
None
UML  A 598 (-3.1A)
 0.59A 5fa8A-4c13A:
4.0		 5fa8A-4c13A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg4 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 THR A 771
ASP A 616
GLU A 784
 None
 0.66A 5fa8A-4cg4A:
undetectable		 5fa8A-4cg4A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		3 THR A 308
ASP A 317
GLU A  21
 None
 0.84A 5fa8A-4d47A:
undetectable		 5fa8A-4d47A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4z DEOXYHYPUSINE
HYDROXYLASE

(Homo sapiens) 		PF13646
(HEAT_2) 		3 THR A  81
ASP A 113
GLU A 117
 None
 0.58A 5fa8A-4d4zA:
undetectable		 5fa8A-4d4zA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ec7 VENOM NERVE GROWTH
FACTOR

(Naja atra) 		PF00243
(NGF) 		3 THR A  27
ASP A  82
GLU A  53
 None
 0.80A 5fa8A-4ec7A:
undetectable		 5fa8A-4ec7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eku PROTEIN-TYROSINE
KINASE 2-BETA

(Homo sapiens) 		PF00373
(FERM_M) 		3 THR A 110
ASP A 116
GLU A 119
 None
 0.86A 5fa8A-4ekuA:
undetectable		 5fa8A-4ekuA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13

(Candida
albicans) 		PF09084
(NMT1) 		3 THR A   3
ASP A  58
GLU A 212
 None
 0.80A 5fa8A-4eswA:
undetectable		 5fa8A-4eswA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN

(Dyadobacter
fermentans) 		PF00501
(AMP-binding) 		3 THR A   8
ASP A 100
GLU A  98
 IOD  A 412 ( 4.6A)
None
None
 0.82A 5fa8A-4gs5A:
undetectable		 5fa8A-4gs5A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 THR A 346
ASP A 169
GLU A 233
 None
 0.75A 5fa8A-4inaA:
undetectable		 5fa8A-4inaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		3 THR A 545
ASP A 220
GLU A 226
 None
 0.79A 5fa8A-4kvoA:
undetectable		 5fa8A-4kvoA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 3 THR A 337
ASP A 414
GLU A 418
 None
 0.84A 5fa8A-4lc9A:
undetectable		 5fa8A-4lc9A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		3 THR A 152
ASP A 255
GLU A 156
 None
None
FE  A 401 (-2.4A)
 0.65A 5fa8A-4m2gA:
undetectable		 5fa8A-4m2gA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzl MYOSIN A TAIL DOMAIN
INTERACTING PROTEIN

(Plasmodium
falciparum) 		no annotation 3 THR A 170
ASP A 177
GLU A 179
 None
 0.83A 5fa8A-4mzlA:
undetectable		 5fa8A-4mzlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		3 THR A 244
ASP A 287
GLU A 129
 None
None
UD1  A 400 (-3.6A)
 0.68A 5fa8A-4nesA:
undetectable		 5fa8A-4nesA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		3 THR A 260
ASP A 140
GLU A 271
 None
 0.80A 5fa8A-4ns4A:
undetectable		 5fa8A-4ns4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 3 THR A 221
ASP A 181
GLU A  87
 None
None
MG  A 901 (-2.6A)
 0.79A 5fa8A-4okmA:
undetectable		 5fa8A-4okmA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF12157
(DUF3591) 		3 THR A 875
ASP A 817
GLU A 551
 None
 0.86A 5fa8A-4oy2A:
undetectable		 5fa8A-4oy2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		3 THR A 222
ASP A  41
GLU A  18
 None
 0.86A 5fa8A-4pqgA:
5.6		 5fa8A-4pqgA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		3 THR A 739
ASP A 685
GLU A 667
 None
 0.75A 5fa8A-4q2cA:
undetectable		 5fa8A-4q2cA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 THR B 542
ASP B 415
GLU B 350
 None
 0.75A 5fa8A-4q4aB:
undetectable		 5fa8A-4q4aB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 3 THR H 210
ASP H 117
GLU H 189
 None
 0.80A 5fa8A-4qfkH:
undetectable		 5fa8A-4qfkH:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 THR A 365
ASP A 188
GLU A 252
 None
 0.81A 5fa8A-4rl6A:
undetectable		 5fa8A-4rl6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 3 THR B 197
ASP B 181
GLU B 210
 None
 0.71A 5fa8A-4rziB:
5.7		 5fa8A-4rziB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II

(Staphylococcus
aureus) 		PF01116
(F_bP_aldolase) 		3 THR A 140
ASP A 107
GLU A 135
 None
 0.85A 5fa8A-4to8A:
undetectable		 5fa8A-4to8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		3 THR A2223
ASP A2692
GLU A2181
 None
 0.79A 5fa8A-4tvcA:
undetectable		 5fa8A-4tvcA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 THR A 178
ASP A 415
GLU A 295
 None
 0.82A 5fa8A-4wv3A:
undetectable		 5fa8A-4wv3A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		3 THR A 158
ASP A 217
GLU A 219
 None
 0.82A 5fa8A-4xhbA:
undetectable		 5fa8A-4xhbA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		3 THR A 869
ASP A 902
GLU A 944
 None
 0.77A 5fa8A-4xqkA:
11.0		 5fa8A-4xqkA:
7.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bxy RNA
METHYLTRANSFERASE

(Salinibacter
ruber) 		PF13847
(Methyltransf_31) 		3 THR A   7
ASP A  29
GLU A  53
 SAH  A 201 (-3.5A)
SAH  A 201 (-2.9A)
SAH  A 201 (-2.8A)
 0.12A 5fa8A-5bxyA:
26.8		 5fa8A-5bxyA:
46.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqr 7-HYDROXYMETHYL
CHLOROPHYLL A
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		3 THR A 110
ASP A 415
GLU A 408
 None
 0.77A 5fa8A-5dqrA:
undetectable		 5fa8A-5dqrA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		3 THR A 258
ASP A 254
GLU A 227
 None
 0.83A 5fa8A-5ejyA:
undetectable		 5fa8A-5ejyA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1p PTMO8

(Streptomyces
platensis) 		PF13561
(adh_short_C2) 		3 THR A  45
ASP A  39
GLU A  62
 None
 0.83A 5fa8A-5f1pA:
6.3		 5fa8A-5f1pA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1q PERIPLASMIC
DIPEPTIDE TRANSPORT
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		3 THR A 210
ASP A 117
GLU A 189
 None
 0.80A 5fa8A-5f1qA:
undetectable		 5fa8A-5f1qA:
16.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE

(Sulfolobus
islandicus) 		PF13847
(Methyltransf_31) 		3 THR A  12
ASP A  34
GLU A  59
 SAH  A 201 (-3.4A)
SAH  A 201 (-2.9A)
SAH  A 201 (-2.9A)
 0.17A 5fa8A-5fadA:
24.4		 5fa8A-5fadA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Escherichia
coli) 		PF00238
(Ribosomal_L14) 		3 THR l 356
ASP l 330
GLU l 396
 None
GNP  l1400 ( 4.7A)
None
 0.78A 5fa8A-5gadl:
undetectable		 5fa8A-5gadl:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 THR A 203
ASP A 365
GLU A 360
 None
 0.79A 5fa8A-5gj8A:
undetectable		 5fa8A-5gj8A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 3 THR G 513
ASP G 532
GLU G 438
 None
 0.80A 5fa8A-5h0rG:
undetectable		 5fa8A-5h0rG:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 3 THR C 316
ASP C 361
GLU C 413
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-2.8A)
 0.54A 5fa8A-5hr4C:
11.0		 5fa8A-5hr4C:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		3 THR A 253
ASP A 312
GLU A 322
 None
 0.72A 5fa8A-5j55A:
undetectable		 5fa8A-5j55A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 THR A1049
ASP A1027
GLU A 923
 None
ATP  A1200 (-4.1A)
None
 0.85A 5fa8A-5lpyA:
undetectable		 5fa8A-5lpyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 THR A1049
ASP A1027
GLU A 923
 None
ADP  A1200 (-3.4A)
None
 0.80A 5fa8A-5lpzA:
undetectable		 5fa8A-5lpzA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 THR A 241
ASP A 237
GLU A 544
 None
 0.67A 5fa8A-5lx8A:
undetectable		 5fa8A-5lx8A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 3 THR A 100
ASP A 118
GLU A 113
 None
 0.74A 5fa8A-5oc1A:
undetectable		 5fa8A-5oc1A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1

(Norwalk virus;
Mus musculus) 		no annotation
no annotation 		3 THR A 363
ASP C  98
GLU C  49
 None
NA  C 401 (-2.9A)
None
 0.79A 5fa8A-5or7A:
undetectable		 5fa8A-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE
FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF10418
(DHODB_Fe-S_bind) 		3 THR A 251
ASP B 225
GLU A 270
 None
FES  B 302 (-2.5A)
None
 0.85A 5fa8A-5vj7A:
undetectable		 5fa8A-5vj7A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 3 THR A 173
ASP A 195
GLU A 233
 SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-2.7A)
 0.74A 5fa8A-5ybbA:
10.8		 5fa8A-5ybbA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygf GH18329P

(Drosophila
melanogaster) 		no annotation 3 THR A 433
ASP A 348
GLU A 331
 None
 0.83A 5fa8A-5ygfA:
undetectable		 5fa8A-5ygfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et8 -

(-) 		no annotation 3 THR A  26
ASP A  63
GLU A  18
 None
 0.74A 5fa8A-6et8A:
undetectable		 5fa8A-6et8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f49 -

(-) 		no annotation 3 THR A 135
ASP A 118
GLU A 206
 None
 0.85A 5fa8A-6f49A:
undetectable		 5fa8A-6f49A:
undetectable