SIMILAR PATTERNS OF AMINO ACIDS FOR 5F9Z_B_HFGB703_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | ANTHRANILATESYNTHASE (Serratiamarcescens) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 4 | THR A 425GLU A 309THR A 329HIS A 398 | BEZ A1501 (-4.7A)BEZ A1501 (-3.8A)BEZ A1501 (-3.9A)BEZ A1501 ( 4.2A) | 1.37A | 5f9zB-1i7qA:1.0 | 5f9zB-1i7qA:19.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nj1 | PROLINE-TRNASYNTHETASE (Methanothermobacterthermautotrophicus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | THR A 117GLU A 119THR A 235HIS A 237 | 5CA A 512 (-3.5A)5CA A 512 (-3.0A)5CA A 512 (-3.0A)5CA A 512 (-4.4A) | 0.52A | 5f9zB-1nj1A:42.9 | 5f9zB-1nj1A:35.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nj8 | PROLINE-TRNASYNTHETASE (Methanocaldococcusjannaschii) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09181(ProRS-C_2) | 4 | THR A 101GLU A 103THR A 219HIS A 221 | None | 0.78A | 5f9zB-1nj8A:41.6 | 5f9zB-1nj8A:36.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdl | PROTEIN(ANTHRANILATESYNTHASE(TRPE-SUBUNIT)) (Sulfolobussolfataricus) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 4 | THR A 333GLU A 225THR A 243HIS A 306 | None | 1.39A | 5f9zB-1qdlA:undetectable | 5f9zB-1qdlA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hih | LIPASE 46 KDA FORM (Staphylococcushyicus) |
no annotation | 4 | THR A 261GLU A 328THR A 172HIS A 177 | None | 1.26A | 5f9zB-2hihA:0.3 | 5f9zB-2hihA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfm | ADENYLOSUCCINATELYASE (Bacillusanthracis) |
PF00206(Lyase_1)PF10397(ADSL_C) | 4 | THR A 250GLU A 252THR A 350HIS A 146 | None | 1.40A | 5f9zB-2pfmA:0.0 | 5f9zB-2pfmA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7t | ENVELOPE PROTEIN (Dengue virus) |
PF00869(Flavi_glycoprot)PF02832(Flavi_glycop_C) | 4 | THR A 353GLU A 26THR A 315HIS A 317 | None | 1.33A | 5f9zB-3g7tA:undetectable | 5f9zB-3g7tA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r75 | ANTHRANILATE/PARA-AMINOBENZOATESYNTHASES COMPONENTI (Burkholderialata) |
PF00117(GATase)PF00425(Chorismate_bind) | 4 | THR A 304GLU A 201THR A 219HIS A 279 | BEZ A 701 (-4.7A)BEZ A 701 ( 4.3A)BEZ A 701 (-4.0A)BEZ A 701 (-3.8A) | 1.45A | 5f9zB-3r75A:undetectable | 5f9zB-3r75A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rao | PUTATIVELUCIFERASE-LIKEMONOOXYGENASE (Bacillus cereus) |
PF00296(Bac_luciferase) | 4 | THR A 66GLU A 63THR A 94HIS A 89 | None | 1.20A | 5f9zB-3raoA:0.8 | 5f9zB-3raoA:23.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydq | PROLINE--TRNA LIGASE (Plasmodiumfalciparum) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | THR A 359GLU A 361THR A 478HIS A 480 | HFG A 802 (-3.2A)HFG A 802 (-2.9A)HFG A 802 ( 4.0A)HFG A 802 (-4.0A) | 0.39A | 5f9zB-4ydqA:51.0 | 5f9zB-4ydqA:57.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwa | ANTHRANILATESYNTHASE COMPONENT 1 (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 4 | THR A 415GLU A 307THR A 325HIS A 388 | None0GA A 604 ( 4.5A)0GA A 604 ( 4.6A)0GA A 604 ( 4.3A) | 1.43A | 5f9zB-5cwaA:undetectable | 5f9zB-5cwaA:19.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vad | BIFUNCTIONALGLUTAMATE/PROLINE--TRNA LIGASE (Homo sapiens) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | THR A1121GLU A1123THR A1240HIS A1242 | PRO A1602 (-3.5A)PRO A1602 (-2.8A)91Y A1601 (-4.2A)PRO A1602 (-4.1A) | 0.52A | 5f9zB-5vadA:48.4 | 5f9zB-5vadA:54.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vvr | DNA REPAIR ANDRECOMBINATIONPROTEIN RAD26 (Saccharomycescerevisiae) |
no annotation | 4 | THR M 506GLU M 507THR M 499HIS M 472 | None | 1.31A | 5f9zB-5vvrM:undetectable | 5f9zB-5vvrM:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xii | PROLYL-TRNASYNTHETASE (PRORS) (Toxoplasmagondii) |
no annotation | 4 | THR A 439GLU A 441THR A 558HIS A 560 | 86X A1004 (-3.6A)86X A1004 (-3.0A)86X A1004 (-3.9A)86X A1004 (-3.7A) | 0.24A | 5f9zB-5xiiA:51.9 | 5f9zB-5xiiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xio | PROLINE-TRNASYNTHETASE CLASS IIAARS (YBAK RNABINDING DOMAIN PLUSTRNA SYNTHETASE) (Cryptosporidiumparvum) |
no annotation | 4 | THR A 331GLU A 333THR A 450HIS A 452 | HFG A 801 (-3.4A)HFG A 801 (-3.0A)ANP A 803 (-3.9A)HFG A 801 (-4.2A) | 0.52A | 5f9zB-5xioA:51.6 | 5f9zB-5xioA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xip | PROLYL-TRNASYNTHETASE, PUTATIVE (Eimeria tenella) |
no annotation | 4 | THR A 359GLU A 361THR A 478HIS A 480 | HFG A1003 (-3.9A)HFG A1003 (-2.9A)ANP A1001 ( 3.7A)HFG A1003 (-3.5A) | 0.41A | 5f9zB-5xipA:50.8 | 5f9zB-5xipA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk8 | PRE-MRNA-SPLICINGFACTOR SYF1 (Saccharomycescerevisiae) |
no annotation | 4 | THR U 796GLU U 788THR U 758HIS U 791 | None | 1.33A | 5f9zB-6bk8U:undetectable | 5f9zB-6bk8U:undetectable |