SIMILAR PATTERNS OF AMINO ACIDS FOR 5F9Z_B_HFGB703_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		5 PHE A 220
VAL A 219
PRO A 195
PHE A 276
GLY A 279
 None
 1.29A 5f9zB-1a5cA:
undetectable		 5f9zB-1a5cA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A  74
PRO A 187
ARG A 220
SER A 361
GLY A 363
 None
 1.37A 5f9zB-1atiA:
25.2		 5f9zB-1atiA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		5 LEU A   4
VAL A 302
ARG A 133
PHE A 213
GLY A  43
 None
 1.34A 5f9zB-1azwA:
undetectable		 5f9zB-1azwA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 500
SER A 542
GLU A 543
PHE A 763
GLY A 866
 None
None
None
None
MCN  A 914 (-3.6A)
 1.34A 5f9zB-1dgjA:
undetectable		 5f9zB-1dgjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 LEU A  29
PHE A 119
VAL A 123
PRO A 297
ARG A 133
 None
 1.24A 5f9zB-1h3jA:
undetectable		 5f9zB-1h3jA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		9 LEU A  77
SER A  88
PRO A 110
ARG A 142
TRP A 158
GLU A 160
PHE A 205
SER A 258
GLY A 260
 None
 0.93A 5f9zB-1hc7A:
46.0		 5f9zB-1hc7A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 LEU A  91
GLU A 144
TRP A 158
GLU A 160
GLY A 260
 None
 1.12A 5f9zB-1hc7A:
46.0		 5f9zB-1hc7A:
40.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5a CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c) 		5 SER A 520
GLU A 515
VAL A 514
SER A 492
GLY A 490
 None
None
None
ACP  A 998 ( 3.7A)
None
 1.31A 5f9zB-1i5aA:
undetectable		 5f9zB-1i5aA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		5 LEU A 346
SER A 382
VAL A 378
SER A 314
GLY A 190
 None
 1.36A 5f9zB-1ihpA:
undetectable		 5f9zB-1ihpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr1 HEVAMINE A

(Hevea
brasiliensis) 		PF00704
(Glyco_hydro_18) 		5 LEU A 170
PHE A 175
VAL A 178
PRO A 157
GLY A  81
 None
None
None
None
NAG  A 903 ( 3.5A)
 1.11A 5f9zB-1kr1A:
undetectable		 5f9zB-1kr1A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgy TRIACYLGLYCEROL
LIPASE

(Rhizopus niveus) 		PF01764
(Lipase_3) 		5 LEU A 152
GLU A 190
VAL A 189
PRO A 219
SER A 245
 None
 1.26A 5f9zB-1lgyA:
undetectable		 5f9zB-1lgyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m41 FMNH2-DEPENDENT
ALKANESULFONATE
MONOOXYGENASE

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		5 LEU A 106
PHE A 175
GLU A 188
VAL A 190
GLY A 151
 None
 1.20A 5f9zB-1m41A:
undetectable		 5f9zB-1m41A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 GLU A 150
ARG A 148
GLU A 168
PHE A 212
GLY A 267
 5CA  A 512 (-4.1A)
5CA  A 512 (-2.9A)
None
5CA  A 512 (-4.0A)
5CA  A 512 (-3.9A)
 1.03A 5f9zB-1nj1A:
42.9		 5f9zB-1nj1A:
35.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 GLU A 150
PRO A 116
ARG A 148
GLU A 168
GLY A 267
 5CA  A 512 (-4.1A)
None
5CA  A 512 (-2.9A)
None
5CA  A 512 (-3.9A)
 0.90A 5f9zB-1nj1A:
42.9		 5f9zB-1nj1A:
35.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 LEU A  83
GLU A  96
VAL A  97
ARG A 148
GLU A 168
PHE A 212
GLY A 267
 None
None
None
5CA  A 512 (-2.9A)
None
5CA  A 512 (-4.0A)
5CA  A 512 (-3.9A)
 1.01A 5f9zB-1nj1A:
42.9		 5f9zB-1nj1A:
35.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 LEU A  83
GLU A  96
VAL A  97
PRO A 116
ARG A 148
GLU A 168
GLY A 267
 None
None
None
None
5CA  A 512 (-2.9A)
None
5CA  A 512 (-3.9A)
 0.60A 5f9zB-1nj1A:
42.9		 5f9zB-1nj1A:
35.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		5 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
 None
 1.14A 5f9zB-1nj8A:
41.6		 5f9zB-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		5 LEU A  67
VAL A  81
PRO A 100
GLU A 152
GLY A 251
 None
 0.40A 5f9zB-1nj8A:
41.6		 5f9zB-1nj8A:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un2 THIOL-DISULFIDE
INTERCHANGE PROTEIN

(Escherichia
coli) 		PF01323
(DSBA) 		5 PHE A  13
VAL A  12
PRO A 181
GLU A 128
PHE A 116
 None
 1.35A 5f9zB-1un2A:
undetectable		 5f9zB-1un2A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LEU A  91
PHE A 297
GLU A 288
PRO A 282
GLY A 312
 None
 1.32A 5f9zB-1v5vA:
undetectable		 5f9zB-1v5vA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 164
SER A 124
GLU A 231
VAL A 123
GLY A 417
 None
 1.34A 5f9zB-1xogA:
undetectable		 5f9zB-1xogA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 334
PHE A 337
VAL A 249
PRO A 255
GLY A 281
 None
 1.21A 5f9zB-2bvgA:
undetectable		 5f9zB-2bvgA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		5 LEU A  71
SER A  99
GLU A 125
SER A  65
GLY A 221
 ACT  A1313 ( 4.7A)
FMN  A1312 ( 4.5A)
None
FMN  A1312 ( 4.2A)
FMN  A1312 (-3.6A)
 1.37A 5f9zB-2bx7A:
undetectable		 5f9zB-2bx7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.04A 5f9zB-2dq3A:
22.4		 5f9zB-2dq3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsj PROTEIN PPL-2

(Parkia
platycephala) 		PF00704
(Glyco_hydro_18) 		5 LEU A 169
PHE A 174
VAL A 177
PRO A 156
GLY A  81
 None
 1.19A 5f9zB-2gsjA:
undetectable		 5f9zB-2gsjA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		5 LEU A 265
PHE A 261
GLU A 385
ARG A 387
TRP A 296
 None
None
None
BSC  A   2 (-2.6A)
BSC  A   2 (-4.0A)
 1.19A 5f9zB-2gwcA:
undetectable		 5f9zB-2gwcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 LEU A  92
PHE A 102
VAL A 105
PRO A  90
GLY A 137
 None
 1.24A 5f9zB-2ho4A:
2.2		 5f9zB-2ho4A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 GLU A  92
PRO A 108
ARG A 140
SER A 315
GLY A 317
 None
None
5CA  A 439 (-2.8A)
5CA  A 439 (-3.6A)
5CA  A 439 (-3.5A)
 0.47A 5f9zB-2i4nA:
28.2		 5f9zB-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A 105
GLU A  92
PRO A 108
ARG A 140
GLY A 317
 None
None
None
5CA  A 439 (-2.8A)
5CA  A 439 (-3.5A)
 1.12A 5f9zB-2i4nA:
28.2		 5f9zB-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A 105
GLU A  92
PRO A 108
GLU A 111
GLY A 203
 None
None
None
5CA  A 439 (-2.6A)
None
 1.33A 5f9zB-2i4nA:
28.2		 5f9zB-2i4nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jig PROLYL-4 HYDROXYLASE

(Chlamydomonas
reinhardtii) 		PF13640
(2OG-FeII_Oxy_3) 		5 PHE A 212
SER A 214
VAL A 163
ARG A 161
GLY A 154
 None
 1.21A 5f9zB-2jigA:
undetectable		 5f9zB-2jigA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 LEU A  44
SER A  47
VAL A  50
SER A 269
GLY A 272
 None
 1.18A 5f9zB-2qfqA:
undetectable		 5f9zB-2qfqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		5 PHE A  67
GLU A 131
VAL A 129
PHE A  88
GLY A 147
 None
 1.27A 5f9zB-2vreA:
undetectable		 5f9zB-2vreA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		5 PHE A  76
SER A  77
GLU A  79
VAL A  80
SER A 111
 None
 1.30A 5f9zB-2ylzA:
undetectable		 5f9zB-2ylzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		5 LEU A 103
GLU A 149
VAL A 161
ARG A 162
GLY A 190
 None
 1.14A 5f9zB-2ywdA:
2.2		 5f9zB-2ywdA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		5 LEU A  88
PHE A  58
GLU A  18
VAL A  17
GLY A  52
 None
None
None
GOL  A 502 ( 4.8A)
None
 1.25A 5f9zB-2yysA:
2.5		 5f9zB-2yysA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0l EARLY ANTIGEN
PROTEIN D

(Human
gammaherpesvirus
4) 		PF04929
(Herpes_DNAp_acc) 		5 LEU A  14
PHE A   9
VAL A  63
PHE A  86
GLY A  30
 None
 1.35A 5f9zB-2z0lA:
undetectable		 5f9zB-2z0lA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 LEU A 495
SER A 372
GLU A 374
VAL A 376
ARG A 378
 None
 1.18A 5f9zB-3a9sA:
undetectable		 5f9zB-3a9sA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF06751
(EutB)
PF05985
(EutC) 		5 LEU B  70
VAL B  78
PRO A 449
PHE A 216
GLY A 435
 None
 1.28A 5f9zB-3anyB:
5.1		 5f9zB-3anyB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3n DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF01180
(DHO_dh) 		5 LEU A  73
SER A  99
GLU A 127
SER A  67
GLY A 224
 LEU  A  73 (-0.6A)
SER  A  99 ( 0.0A)
GLU  A 127 ( 0.5A)
SER  A  67 ( 0.0A)
GLY  A 224 (-0.0A)
 1.34A 5f9zB-3c3nA:
undetectable		 5f9zB-3c3nA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 143
SER A 161
VAL A 162
GLU A 689
GLY A 687
 None
 1.34A 5f9zB-3ddrA:
undetectable		 5f9zB-3ddrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE

(Oenococcus oeni) 		PF12697
(Abhydrolase_6) 		5 LEU A  75
SER A  68
PRO A  55
SER A  33
GLY A 175
 None
 1.06A 5f9zB-3fsgA:
2.8		 5f9zB-3fsgA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		5 PHE A  47
SER A  90
GLU A 433
PHE A 437
GLY A 429
 None
 1.08A 5f9zB-3h9cA:
undetectable		 5f9zB-3h9cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
 None
 1.10A 5f9zB-3i04A:
4.5		 5f9zB-3i04A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 LEU A 112
GLU A 125
ARG A 177
GLU A 196
PHE A 241
 None
None
PR8  A 601 ( 4.3A)
PR8  A 601 (-4.5A)
PR8  A 601 ( 4.1A)
 0.90A 5f9zB-3ialA:
42.6		 5f9zB-3ialA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 LEU A 112
GLU A 125
PRO A 145
ARG A 177
GLY A 264
 None
None
None
PR8  A 601 ( 4.3A)
PR8  A 601 (-3.5A)
 1.01A 5f9zB-3ialA:
42.6		 5f9zB-3ialA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 LEU A 112
GLU A 125
PRO A 145
ARG A 177
TRP A 194
GLU A 196
GLY A 296
 None
None
None
PR8  A 601 ( 4.3A)
None
PR8  A 601 (-4.5A)
PR8  A 601 (-3.4A)
 0.38A 5f9zB-3ialA:
42.6		 5f9zB-3ialA:
34.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 LEU A 496
GLU A 510
VAL A 511
GLU A 517
GLY A 521
 None
 1.26A 5f9zB-3ib3A:
2.1		 5f9zB-3ib3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j15 PROTEIN PELOTA

(Pyrococcus
furiosus) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 LEU A 124
GLU A   6
VAL A  13
GLU A  18
GLY A 155
 None
 1.31A 5f9zB-3j15A:
undetectable		 5f9zB-3j15A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		5 LEU A  80
VAL A  91
PRO A 101
SER A 298
GLY A  26
 None
None
None
CIT  A 400 (-4.9A)
None
 1.35A 5f9zB-3kx6A:
undetectable		 5f9zB-3kx6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		5 PHE A 212
VAL A 211
PRO A 187
PHE A 268
GLY A 271
 None
None
None
None
CIT  A 400 (-3.4A)
 1.33A 5f9zB-3kx6A:
undetectable		 5f9zB-3kx6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		5 PHE A 207
VAL A 206
PRO A 179
PHE A 262
GLY A 265
 None
None
None
None
2FP  A 350 (-3.5A)
 1.35A 5f9zB-3mmtA:
undetectable		 5f9zB-3mmtA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 LEU A 273
PHE A 271
PRO A 321
SER A 342
GLY A 304
 None
 1.15A 5f9zB-3of7A:
undetectable		 5f9zB-3of7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oix PUTATIVE
DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
OXIDASE

(Streptococcus
mutans) 		PF01180
(DHO_dh) 		5 LEU A  73
SER A 100
GLU A 126
SER A  67
GLY A 220
 None
MLY  A  45 ( 4.6A)
None
FMN  A 400 ( 3.8A)
FMN  A 400 (-3.4A)
 1.34A 5f9zB-3oixA:
undetectable		 5f9zB-3oixA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		5 LEU A1560
PHE A1513
GLU A1515
PHE A1500
GLY A1481
 None
 1.18A 5f9zB-3pvlA:
undetectable		 5f9zB-3pvlA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 LEU A  21
PHE A 111
VAL A 115
PRO A 288
ARG A 125
 None
 1.26A 5f9zB-3q3uA:
undetectable		 5f9zB-3q3uA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum) 		PF00224
(PK)
PF02887
(PK_C) 		5 LEU A 187
PHE A 223
SER A 225
VAL A 200
GLY A  24
 None
 1.20A 5f9zB-3qtgA:
3.0		 5f9zB-3qtgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 600
PHE A 535
VAL A 532
PRO A 595
GLY A 627
 None
None
None
GOL  A   6 ( 4.6A)
None
 1.33A 5f9zB-3s95A:
undetectable		 5f9zB-3s95A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)

(Borreliella
burgdorferi) 		PF04069
(OpuAC) 		5 LEU A  45
PHE A 241
GLU A  38
VAL A  79
GLY A 260
 None
None
BET  A 310 (-4.1A)
None
None
 1.37A 5f9zB-3tmgA:
3.1		 5f9zB-3tmgA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		5 LEU A 158
VAL A 248
PRO A 245
ARG A 249
GLY A 202
 None
 1.36A 5f9zB-4binA:
5.2		 5f9zB-4binA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		5 VAL A  83
TRP A  42
GLU A 199
SER A 201
GLY A 198
 None
 1.35A 5f9zB-4binA:
5.2		 5f9zB-4binA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		5 PHE A 285
VAL A 284
PRO A 260
PHE A 341
GLY A 344
 None
 1.31A 5f9zB-4d2jA:
undetectable		 5f9zB-4d2jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 5 LEU P  30
PHE P  26
SER P 130
VAL P 129
GLY P 118
 None
 1.04A 5f9zB-4dvyP:
undetectable		 5f9zB-4dvyP:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2

(Pleurotus
eryngii) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 LEU A  21
PHE A 105
VAL A 109
PRO A 283
ARG A 119
 None
 1.22A 5f9zB-4fcsA:
undetectable		 5f9zB-4fcsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k46 ADENYLATE KINASE

(Photobacterium
profundum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 LEU A 168
SER A 114
GLU A 118
VAL A 117
ARG A 119
 None
None
None
None
ADP  A 301 (-3.6A)
 1.23A 5f9zB-4k46A:
undetectable		 5f9zB-4k46A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcb CELL DIVISION
PROTEIN CDVC, VPS4

(Acidianus
hospitalis) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 266
SER A 346
VAL A 347
PRO A 136
GLY A 242
 None
 1.32A 5f9zB-4lcbA:
undetectable		 5f9zB-4lcbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qei GLYCINE--TRNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A 135
PRO A 244
ARG A 277
GLU A 296
GLY A 406
 None
None
AMP  A 701 (-2.9A)
None
AMP  A 701 (-4.0A)
 0.90A 5f9zB-4qeiA:
23.6		 5f9zB-4qeiA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 451
VAL A 437
PRO A 136
SER A  30
GLY A 164
 None
 1.37A 5f9zB-4ruhA:
undetectable		 5f9zB-4ruhA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toq CLASS III CHITINASE

(Punica granatum) 		PF00704
(Glyco_hydro_18) 		5 LEU A 170
PHE A 175
VAL A 178
PRO A 157
GLY A  81
 None
 1.22A 5f9zB-4toqA:
undetectable		 5f9zB-4toqA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 GLU A 823
VAL A 824
GLU A 356
PHE A 342
GLY A 363
 None
 1.22A 5f9zB-4wd9A:
undetectable		 5f9zB-4wd9A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9

(Drosophila
melanogaster) 		PF07679
(I-set) 		5 PHE A 245
SER A 244
VAL A 290
PRO A 212
GLY A 208
 GOL  A 409 ( 4.8A)
None
None
None
SO4  A 411 ( 4.7A)
 1.37A 5f9zB-4x9fA:
undetectable		 5f9zB-4x9fA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 GLU A 392
ARG A 390
GLU A 409
SER A 508
GLY A 510
 ANP  A 801 (-3.6A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 1.30A 5f9zB-4ydqA:
51.0		 5f9zB-4ydqA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		9 LEU A 325
GLU A 338
VAL A 339
PRO A 358
ARG A 390
GLU A 409
PHE A 454
SER A 508
GLY A 510
 None
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.35A 5f9zB-4ydqA:
51.0		 5f9zB-4ydqA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		9 LEU A 325
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
PHE A 454
SER A 508
GLY A 510
 None
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.67A 5f9zB-4ydqA:
51.0		 5f9zB-4ydqA:
57.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 PHE A 181
SER A 183
ARG A 168
PHE A  36
GLY A  77
 None
 1.27A 5f9zB-4zohA:
undetectable		 5f9zB-4zohA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 166
PHE A 230
VAL A 202
PRO A 200
GLY A 244
 None
 1.35A 5f9zB-4zyjA:
undetectable		 5f9zB-4zyjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.21A 5f9zB-5cioA:
undetectable		 5f9zB-5cioA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		5 LEU A   7
PRO A  92
PHE A 144
SER A 106
GLY A 109
 None
 1.16A 5f9zB-5czwA:
undetectable		 5f9zB-5czwA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Aspergillus
fumigatus) 		PF02358
(Trehalose_PPase) 		5 GLU A 171
VAL A 170
PRO A 183
SER A  84
GLY A  65
 None
 1.34A 5f9zB-5dxlA:
3.7		 5f9zB-5dxlA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0q BETA-GLUCURONIDASE

(Acidobacterium
capsulatum) 		PF03662
(Glyco_hydro_79n) 		5 LEU A 176
GLU A 245
GLU A  45
SER A  43
GLY A 328
 None
None
IF6  A1476 (-2.9A)
None
None
 1.28A 5f9zB-5g0qA:
undetectable		 5f9zB-5g0qA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.06A 5f9zB-5gkqA:
undetectable		 5f9zB-5gkqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		5 LEU A 483
SER A 479
VAL A 331
PRO A 329
SER A 137
 None
None
1VU  A 601 ( 4.2A)
1VU  A 601 (-4.6A)
None
 1.37A 5f9zB-5jfmA:
3.4		 5f9zB-5jfmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mih PA-I GALACTOPHILIC
LECTIN

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A  65
PHE A 112
SER A 111
GLU A   5
VAL A   6
 None
 1.33A 5f9zB-5mihA:
undetectable		 5f9zB-5mihA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 LEU A 381
SER A 341
GLU A 339
GLU A 153
GLY A 128
 None
 1.32A 5f9zB-5ngkA:
undetectable		 5f9zB-5ngkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 LEU A 213
PHE A 258
SER A 257
PHE A 126
GLY A 131
 LEU  A 213 ( 0.6A)
PHE  A 258 ( 1.3A)
SER  A 257 ( 0.0A)
PHE  A 126 ( 1.3A)
GLY  A 131 ( 0.0A)
 1.08A 5f9zB-5svdA:
undetectable		 5f9zB-5svdA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus;
Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11)
PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		5 LEU A 408
PHE A 427
VAL A 425
PHE A 363
GLY B 345
 None
 1.17A 5f9zB-5sy5A:
undetectable		 5f9zB-5sy5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttk AMINE OXIDASE

(Pseudomonas
putida) 		PF01593
(Amino_oxidase) 		5 LEU A 322
PHE A 318
GLU A 476
SER A 469
GLY A 474
 None
 1.09A 5f9zB-5ttkA:
undetectable		 5f9zB-5ttkA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		9 LEU A1087
GLU A1100
VAL A1101
PRO A1120
ARG A1152
TRP A1169
GLU A1171
SER A1272
GLY A1274
 None
None
None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.77A 5f9zB-5vadA:
48.4		 5f9zB-5vadA:
54.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		8 LEU A1087
VAL A1101
PRO A1120
TRP A1169
GLU A1171
PHE A1216
SER A1272
GLY A1274
 None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.72A 5f9zB-5vadA:
48.4		 5f9zB-5vadA:
54.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 5 LEU B 585
PHE B 574
SER B 567
SER B  84
GLY B   5
 None
 1.34A 5f9zB-5xguB:
undetectable		 5f9zB-5xguB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 6 GLU A 472
ARG A 470
TRP A 487
GLU A 489
SER A 588
GLY A 590
 ANP  A1001 (-3.4A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 1.29A 5f9zB-5xiiA:
51.9		 5f9zB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 10 LEU A 405
GLU A 418
VAL A 419
PRO A 438
ARG A 470
TRP A 487
GLU A 489
PHE A 534
SER A 588
GLY A 590
 None
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.28A 5f9zB-5xiiA:
51.9		 5f9zB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 6 LEU A 405
SER A 416
VAL A 419
GLU A 489
PHE A 534
SER A 588
 None
None
86X  A1004 (-4.2A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
 1.20A 5f9zB-5xiiA:
51.9		 5f9zB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 5 TRP A 407
GLU A 409
PHE A 454
SER A 510
GLY A 512
 None
 0.43A 5f9zB-5xilA:
46.7		 5f9zB-5xilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 6 GLU A 364
ARG A 362
TRP A 379
GLU A 381
SER A 480
GLY A 482
 ANP  A 803 (-3.7A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 1.30A 5f9zB-5xioA:
51.6		 5f9zB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 8 LEU A 297
GLU A 310
VAL A 311
PRO A 330
ARG A 362
PHE A 426
SER A 480
GLY A 482
 None
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.64A 5f9zB-5xioA:
51.6		 5f9zB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 9 LEU A 297
VAL A 311
PRO A 330
ARG A 362
TRP A 379
GLU A 381
PHE A 426
SER A 480
GLY A 482
 None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.30A 5f9zB-5xioA:
51.6		 5f9zB-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 6 GLU A 392
ARG A 390
TRP A 407
GLU A 409
SER A 508
GLY A 510
 ANP  A1001 (-3.8A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 1.20A 5f9zB-5xipA:
50.8		 5f9zB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 10 LEU A 325
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
PHE A 454
SER A 508
GLY A 510
 None
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 (-3.4A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.35A 5f9zB-5xipA:
50.8		 5f9zB-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpc PRO-PRO
ENDOPEPTIDASE

(Paenibacillus
alvei) 		no annotation 5 PHE A 183
SER A 152
GLU A 150
VAL A 151
GLY A  71
 None
 1.28A 5f9zB-6fpcA:
undetectable		 5f9zB-6fpcA:
undetectable