SIMILAR PATTERNS OF AMINO ACIDS FOR 5F9Z_B_HFGB703
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5c | FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE (Plasmodiumfalciparum) |
PF00274(Glycolytic) | 5 | PHE A 220VAL A 219PRO A 195PHE A 276GLY A 279 | None | 1.29A | 5f9zB-1a5cA:undetectable | 5f9zB-1a5cA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ati | GLYCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 5 | LEU A 74PRO A 187ARG A 220SER A 361GLY A 363 | None | 1.37A | 5f9zB-1atiA:25.2 | 5f9zB-1atiA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1azw | PROLINEIMINOPEPTIDASE (Xanthomonascitri) |
PF00561(Abhydrolase_1) | 5 | LEU A 4VAL A 302ARG A 133PHE A 213GLY A 43 | None | 1.34A | 5f9zB-1azwA:undetectable | 5f9zB-1azwA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgj | ALDEHYDEOXIDOREDUCTASE (Desulfovibriodesulfuricans) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 5 | LEU A 500SER A 542GLU A 543PHE A 763GLY A 866 | NoneNoneNoneNoneMCN A 914 (-3.6A) | 1.34A | 5f9zB-1dgjA:undetectable | 5f9zB-1dgjA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3j | PEROXIDASE (Coprinopsiscinerea) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | LEU A 29PHE A 119VAL A 123PRO A 297ARG A 133 | None | 1.24A | 5f9zB-1h3jA:undetectable | 5f9zB-1h3jA:19.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hc7 | PROLYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 9 | LEU A 77SER A 88PRO A 110ARG A 142TRP A 158GLU A 160PHE A 205SER A 258GLY A 260 | None | 0.93A | 5f9zB-1hc7A:46.0 | 5f9zB-1hc7A:40.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hc7 | PROLYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 5 | LEU A 91GLU A 144TRP A 158GLU A 160GLY A 260 | None | 1.12A | 5f9zB-1hc7A:46.0 | 5f9zB-1hc7A:40.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i5a | CHEMOTAXIS PROTEINCHEA (Thermotogamaritima) |
PF02518(HATPase_c) | 5 | SER A 520GLU A 515VAL A 514SER A 492GLY A 490 | NoneNoneNoneACP A 998 ( 3.7A)None | 1.31A | 5f9zB-1i5aA:undetectable | 5f9zB-1i5aA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ihp | PHYTASE (Aspergillusficuum) |
PF00328(His_Phos_2) | 5 | LEU A 346SER A 382VAL A 378SER A 314GLY A 190 | None | 1.36A | 5f9zB-1ihpA:undetectable | 5f9zB-1ihpA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kr1 | HEVAMINE A (Heveabrasiliensis) |
PF00704(Glyco_hydro_18) | 5 | LEU A 170PHE A 175VAL A 178PRO A 157GLY A 81 | NoneNoneNoneNoneNAG A 903 ( 3.5A) | 1.11A | 5f9zB-1kr1A:undetectable | 5f9zB-1kr1A:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lgy | TRIACYLGLYCEROLLIPASE (Rhizopus niveus) |
PF01764(Lipase_3) | 5 | LEU A 152GLU A 190VAL A 189PRO A 219SER A 245 | None | 1.26A | 5f9zB-1lgyA:undetectable | 5f9zB-1lgyA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m41 | FMNH2-DEPENDENTALKANESULFONATEMONOOXYGENASE (Escherichiacoli) |
PF00296(Bac_luciferase) | 5 | LEU A 106PHE A 175GLU A 188VAL A 190GLY A 151 | None | 1.20A | 5f9zB-1m41A:undetectable | 5f9zB-1m41A:20.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nj1 | PROLINE-TRNASYNTHETASE (Methanothermobacterthermautotrophicus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 5 | GLU A 150ARG A 148GLU A 168PHE A 212GLY A 267 | 5CA A 512 (-4.1A)5CA A 512 (-2.9A)None5CA A 512 (-4.0A)5CA A 512 (-3.9A) | 1.03A | 5f9zB-1nj1A:42.9 | 5f9zB-1nj1A:35.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nj1 | PROLINE-TRNASYNTHETASE (Methanothermobacterthermautotrophicus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 5 | GLU A 150PRO A 116ARG A 148GLU A 168GLY A 267 | 5CA A 512 (-4.1A)None5CA A 512 (-2.9A)None5CA A 512 (-3.9A) | 0.90A | 5f9zB-1nj1A:42.9 | 5f9zB-1nj1A:35.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nj1 | PROLINE-TRNASYNTHETASE (Methanothermobacterthermautotrophicus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 7 | LEU A 83GLU A 96VAL A 97ARG A 148GLU A 168PHE A 212GLY A 267 | NoneNoneNone5CA A 512 (-2.9A)None5CA A 512 (-4.0A)5CA A 512 (-3.9A) | 1.01A | 5f9zB-1nj1A:42.9 | 5f9zB-1nj1A:35.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nj1 | PROLINE-TRNASYNTHETASE (Methanothermobacterthermautotrophicus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 7 | LEU A 83GLU A 96VAL A 97PRO A 116ARG A 148GLU A 168GLY A 267 | NoneNoneNoneNone5CA A 512 (-2.9A)None5CA A 512 (-3.9A) | 0.60A | 5f9zB-1nj1A:42.9 | 5f9zB-1nj1A:35.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nj8 | PROLINE-TRNASYNTHETASE (Methanocaldococcusjannaschii) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09181(ProRS-C_2) | 5 | LEU A 67GLU A 80VAL A 81PRO A 100PHE A 196 | None | 1.14A | 5f9zB-1nj8A:41.6 | 5f9zB-1nj8A:36.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nj8 | PROLINE-TRNASYNTHETASE (Methanocaldococcusjannaschii) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09181(ProRS-C_2) | 5 | LEU A 67VAL A 81PRO A 100GLU A 152GLY A 251 | None | 0.40A | 5f9zB-1nj8A:41.6 | 5f9zB-1nj8A:36.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1un2 | THIOL-DISULFIDEINTERCHANGE PROTEIN (Escherichiacoli) |
PF01323(DSBA) | 5 | PHE A 13VAL A 12PRO A 181GLU A 128PHE A 116 | None | 1.35A | 5f9zB-1un2A:undetectable | 5f9zB-1un2A:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5v | AMINOMETHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | LEU A 91PHE A 297GLU A 288PRO A 282GLY A 312 | None | 1.32A | 5f9zB-1v5vA:undetectable | 5f9zB-1v5vA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xog | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | LEU A 164SER A 124GLU A 231VAL A 123GLY A 417 | None | 1.34A | 5f9zB-1xogA:undetectable | 5f9zB-1xogA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvg | 6-HYDROXY-D-NICOTINEOXIDASE (Paenarthrobacternicotinovorans) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | LEU A 334PHE A 337VAL A 249PRO A 255GLY A 281 | None | 1.21A | 5f9zB-2bvgA:undetectable | 5f9zB-2bvgA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bx7 | DIHYDROOROTATEDEHYDROGENASE (Lactococcuslactis) |
PF01180(DHO_dh) | 5 | LEU A 71SER A 99GLU A 125SER A 65GLY A 221 | ACT A1313 ( 4.7A)FMN A1312 ( 4.5A)NoneFMN A1312 ( 4.2A)FMN A1312 (-3.6A) | 1.37A | 5f9zB-2bx7A:undetectable | 5f9zB-2bx7A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq3 | SERYL-TRNASYNTHETASE (Aquifexaeolicus) |
PF00587(tRNA-synt_2b)PF02403(Seryl_tRNA_N) | 5 | GLU A 264ARG A 262GLU A 233SER A 354GLY A 384 | SSA A1001 (-3.3A)SSA A1001 (-2.8A)SSA A1001 (-3.7A)NoneSSA A1001 (-3.7A) | 1.04A | 5f9zB-2dq3A:22.4 | 5f9zB-2dq3A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsj | PROTEIN PPL-2 (Parkiaplatycephala) |
PF00704(Glyco_hydro_18) | 5 | LEU A 169PHE A 174VAL A 177PRO A 156GLY A 81 | None | 1.19A | 5f9zB-2gsjA:undetectable | 5f9zB-2gsjA:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwc | GLUTAMATE CYSTEINELIGASE (Brassica juncea) |
PF04107(GCS2) | 5 | LEU A 265PHE A 261GLU A 385ARG A 387TRP A 296 | NoneNoneNoneBSC A 2 (-2.6A)BSC A 2 (-4.0A) | 1.19A | 5f9zB-2gwcA:undetectable | 5f9zB-2gwcA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ho4 | HALOACIDDEHALOGENASE-LIKEHYDROLASE DOMAINCONTAINING 2 (Mus musculus) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 5 | LEU A 92PHE A 102VAL A 105PRO A 90GLY A 137 | None | 1.24A | 5f9zB-2ho4A:2.2 | 5f9zB-2ho4A:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i4n | PROLINE-TRNA LIGASE (Rhodopseudomonaspalustris) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 5 | GLU A 92PRO A 108ARG A 140SER A 315GLY A 317 | NoneNone5CA A 439 (-2.8A)5CA A 439 (-3.6A)5CA A 439 (-3.5A) | 0.47A | 5f9zB-2i4nA:28.2 | 5f9zB-2i4nA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i4n | PROLINE-TRNA LIGASE (Rhodopseudomonaspalustris) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 5 | LEU A 105GLU A 92PRO A 108ARG A 140GLY A 317 | NoneNoneNone5CA A 439 (-2.8A)5CA A 439 (-3.5A) | 1.12A | 5f9zB-2i4nA:28.2 | 5f9zB-2i4nA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i4n | PROLINE-TRNA LIGASE (Rhodopseudomonaspalustris) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 5 | LEU A 105GLU A 92PRO A 108GLU A 111GLY A 203 | NoneNoneNone5CA A 439 (-2.6A)None | 1.33A | 5f9zB-2i4nA:28.2 | 5f9zB-2i4nA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jig | PROLYL-4 HYDROXYLASE (Chlamydomonasreinhardtii) |
PF13640(2OG-FeII_Oxy_3) | 5 | PHE A 212SER A 214VAL A 163ARG A 161GLY A 154 | None | 1.21A | 5f9zB-2jigA:undetectable | 5f9zB-2jigA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfq | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Escherichiacoli) |
PF00275(EPSP_synthase) | 5 | LEU A 44SER A 47VAL A 50SER A 269GLY A 272 | None | 1.18A | 5f9zB-2qfqA:undetectable | 5f9zB-2qfqA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vre | DELTA(3,5)-DELTA(2,4)-DIENOYL-COAISOMERASE (Homo sapiens) |
PF00378(ECH_1) | 5 | PHE A 67GLU A 131VAL A 129PHE A 88GLY A 147 | None | 1.27A | 5f9zB-2vreA:undetectable | 5f9zB-2vreA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ylz | PHENYLACETONEMONOOXYGENASE (Thermobifidafusca) |
PF13738(Pyr_redox_3) | 5 | PHE A 76SER A 77GLU A 79VAL A 80SER A 111 | None | 1.30A | 5f9zB-2ylzA:undetectable | 5f9zB-2ylzA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywd | GLUTAMINEAMIDOTRANSFERASESUBUNIT PDXT (Thermusthermophilus) |
PF01174(SNO) | 5 | LEU A 103GLU A 149VAL A 161ARG A 162GLY A 190 | None | 1.14A | 5f9zB-2ywdA:2.2 | 5f9zB-2ywdA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yys | PROLINEIMINOPEPTIDASE-RELATED PROTEIN (Thermusthermophilus) |
PF12697(Abhydrolase_6) | 5 | LEU A 88PHE A 58GLU A 18VAL A 17GLY A 52 | NoneNoneNoneGOL A 502 ( 4.8A)None | 1.25A | 5f9zB-2yysA:2.5 | 5f9zB-2yysA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z0l | EARLY ANTIGENPROTEIN D (Humangammaherpesvirus4) |
PF04929(Herpes_DNAp_acc) | 5 | LEU A 14PHE A 9VAL A 63PHE A 86GLY A 30 | None | 1.35A | 5f9zB-2z0lA:undetectable | 5f9zB-2z0lA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9s | D-ARABINOSEISOMERASE (Aeribacilluspallidus) |
PF02952(Fucose_iso_C)PF07881(Fucose_iso_N1)PF07882(Fucose_iso_N2) | 5 | LEU A 495SER A 372GLU A 374VAL A 376ARG A 378 | None | 1.18A | 5f9zB-3a9sA:undetectable | 5f9zB-3a9sA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3any | ETHANOLAMINEAMMONIA-LYASE HEAVYCHAINETHANOLAMINEAMMONIA-LYASE LIGHTCHAIN (Escherichiacoli;Escherichiacoli) |
PF06751(EutB)PF05985(EutC) | 5 | LEU B 70VAL B 78PRO A 449PHE A 216GLY A 435 | None | 1.28A | 5f9zB-3anyB:5.1 | 5f9zB-3anyB:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3n | DIHYDROOROTATEDEHYDROGENASE (Trypanosomacruzi) |
PF01180(DHO_dh) | 5 | LEU A 73SER A 99GLU A 127SER A 67GLY A 224 | LEU A 73 (-0.6A)SER A 99 ( 0.0A)GLU A 127 ( 0.5A)SER A 67 ( 0.0A)GLY A 224 (-0.0A) | 1.34A | 5f9zB-3c3nA:undetectable | 5f9zB-3c3nA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddr | HASR PROTEIN (Serratiamarcescens) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | LEU A 143SER A 161VAL A 162GLU A 689GLY A 687 | None | 1.34A | 5f9zB-3ddrA:undetectable | 5f9zB-3ddrA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsg | ALPHA/BETASUPERFAMILYHYDROLASE (Oenococcus oeni) |
PF12697(Abhydrolase_6) | 5 | LEU A 75SER A 68PRO A 55SER A 33GLY A 175 | None | 1.06A | 5f9zB-3fsgA:2.8 | 5f9zB-3fsgA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h9c | METHIONYL-TRNASYNTHETASE (Escherichiacoli) |
PF09334(tRNA-synt_1g) | 5 | PHE A 47SER A 90GLU A 433PHE A 437GLY A 429 | None | 1.08A | 5f9zB-3h9cA:undetectable | 5f9zB-3h9cA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i04 | CARBON MONOXIDEDEHYDROGENASE/ACETYL-COA SYNTHASESUBUNIT BETA (Moorellathermoacetica) |
PF03063(Prismane) | 5 | GLU A 611VAL A 610PRO A 608SER A 480GLY A 475 | None | 1.10A | 5f9zB-3i04A:4.5 | 5f9zB-3i04A:21.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ial | PROLYL-TRNASYNTHETASE (Giardiaintestinalis) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 5 | LEU A 112GLU A 125ARG A 177GLU A 196PHE A 241 | NoneNonePR8 A 601 ( 4.3A)PR8 A 601 (-4.5A)PR8 A 601 ( 4.1A) | 0.90A | 5f9zB-3ialA:42.6 | 5f9zB-3ialA:34.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ial | PROLYL-TRNASYNTHETASE (Giardiaintestinalis) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 5 | LEU A 112GLU A 125PRO A 145ARG A 177GLY A 264 | NoneNoneNonePR8 A 601 ( 4.3A)PR8 A 601 (-3.5A) | 1.01A | 5f9zB-3ialA:42.6 | 5f9zB-3ialA:34.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ial | PROLYL-TRNASYNTHETASE (Giardiaintestinalis) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 7 | LEU A 112GLU A 125PRO A 145ARG A 177TRP A 194GLU A 196GLY A 296 | NoneNoneNonePR8 A 601 ( 4.3A)NonePR8 A 601 (-4.5A)PR8 A 601 (-3.4A) | 0.38A | 5f9zB-3ialA:42.6 | 5f9zB-3ialA:34.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib3 | COCE/NOND FAMILYHYDROLASE (Staphylococcusaureus) |
PF02129(Peptidase_S15)PF08530(PepX_C) | 5 | LEU A 496GLU A 510VAL A 511GLU A 517GLY A 521 | None | 1.26A | 5f9zB-3ib3A:2.1 | 5f9zB-3ib3A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j15 | PROTEIN PELOTA (Pyrococcusfuriosus) |
PF03463(eRF1_1)PF03464(eRF1_2)PF03465(eRF1_3) | 5 | LEU A 124GLU A 6VAL A 13GLU A 18GLY A 155 | None | 1.31A | 5f9zB-3j15A:undetectable | 5f9zB-3j15A:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kx6 | FRUCTOSE-BISPHOSPHATE ALDOLASE (Babesia bovis) |
PF00274(Glycolytic) | 5 | LEU A 80VAL A 91PRO A 101SER A 298GLY A 26 | NoneNoneNoneCIT A 400 (-4.9A)None | 1.35A | 5f9zB-3kx6A:undetectable | 5f9zB-3kx6A:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kx6 | FRUCTOSE-BISPHOSPHATE ALDOLASE (Babesia bovis) |
PF00274(Glycolytic) | 5 | PHE A 212VAL A 211PRO A 187PHE A 268GLY A 271 | NoneNoneNoneNoneCIT A 400 (-3.4A) | 1.33A | 5f9zB-3kx6A:undetectable | 5f9zB-3kx6A:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mmt | FRUCTOSE-BISPHOSPHATE ALDOLASE (Bartonellahenselae) |
PF00274(Glycolytic) | 5 | PHE A 207VAL A 206PRO A 179PHE A 262GLY A 265 | NoneNoneNoneNone2FP A 350 (-3.5A) | 1.35A | 5f9zB-3mmtA:undetectable | 5f9zB-3mmtA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3of7 | REGULATOR OFCHROMOSOMECONDENSATION (Saccharomycescerevisiae) |
PF00415(RCC1)PF13540(RCC1_2) | 5 | LEU A 273PHE A 271PRO A 321SER A 342GLY A 304 | None | 1.15A | 5f9zB-3of7A:undetectable | 5f9zB-3of7A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oix | PUTATIVEDIHYDROOROTATEDEHYDROGENASE DIHYDROOROTATEOXIDASE (Streptococcusmutans) |
PF01180(DHO_dh) | 5 | LEU A 73SER A 100GLU A 126SER A 67GLY A 220 | NoneMLY A 45 ( 4.6A)NoneFMN A 400 ( 3.8A)FMN A 400 (-3.4A) | 1.34A | 5f9zB-3oixA:undetectable | 5f9zB-3oixA:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvl | MYOSIN VIIA ISOFORM1 (Mus musculus) |
PF00784(MyTH4) | 5 | LEU A1560PHE A1513GLU A1515PHE A1500GLY A1481 | None | 1.18A | 5f9zB-3pvlA:undetectable | 5f9zB-3pvlA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3u | LIGNIN PEROXIDASE (Trametopsiscervina) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | LEU A 21PHE A 111VAL A 115PRO A 288ARG A 125 | None | 1.26A | 5f9zB-3q3uA:undetectable | 5f9zB-3q3uA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qtg | PYRUVATE KINASE (Pyrobaculumaerophilum) |
PF00224(PK)PF02887(PK_C) | 5 | LEU A 187PHE A 223SER A 225VAL A 200GLY A 24 | None | 1.20A | 5f9zB-3qtgA:3.0 | 5f9zB-3qtgA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s95 | LIM DOMAIN KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 600PHE A 535VAL A 532PRO A 595GLY A 627 | NoneNoneNoneGOL A 6 ( 4.6A)None | 1.33A | 5f9zB-3s95A:undetectable | 5f9zB-3s95A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tmg | GLYCINE BETAINE,L-PROLINE ABCTRANSPORTER,GLYCINE/BETAINE/L-PROLINE-BINDINGPROTEIN (PROX) (Borreliellaburgdorferi) |
PF04069(OpuAC) | 5 | LEU A 45PHE A 241GLU A 38VAL A 79GLY A 260 | NoneNoneBET A 310 (-4.1A)NoneNone | 1.37A | 5f9zB-3tmgA:3.1 | 5f9zB-3tmgA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bin | N-ACETYLMURAMOYL-L-ALANINE AMIDASE AMIC (Escherichiacoli) |
PF01520(Amidase_3)PF11741(AMIN) | 5 | LEU A 158VAL A 248PRO A 245ARG A 249GLY A 202 | None | 1.36A | 5f9zB-4binA:5.2 | 5f9zB-4binA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bin | N-ACETYLMURAMOYL-L-ALANINE AMIDASE AMIC (Escherichiacoli) |
PF01520(Amidase_3)PF11741(AMIN) | 5 | VAL A 83TRP A 42GLU A 199SER A 201GLY A 198 | None | 1.35A | 5f9zB-4binA:5.2 | 5f9zB-4binA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d2j | FRUCTOSE-BISPHOSPHATE ALDOLASE (Toxoplasmagondii) |
PF00274(Glycolytic) | 5 | PHE A 285VAL A 284PRO A 260PHE A 341GLY A 344 | None | 1.31A | 5f9zB-4d2jA:undetectable | 5f9zB-4d2jA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dvy | CYTOTOXICITY-ASSOCIATED IMMUNODOMINANTANTIGEN (Helicobacterpylori) |
no annotation | 5 | LEU P 30PHE P 26SER P 130VAL P 129GLY P 118 | None | 1.04A | 5f9zB-4dvyP:undetectable | 5f9zB-4dvyP:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcs | VERSATILE PEROXIDASEVPL2 (Pleurotuseryngii) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | LEU A 21PHE A 105VAL A 109PRO A 283ARG A 119 | None | 1.22A | 5f9zB-4fcsA:undetectable | 5f9zB-4fcsA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k46 | ADENYLATE KINASE (Photobacteriumprofundum) |
PF00406(ADK)PF05191(ADK_lid) | 5 | LEU A 168SER A 114GLU A 118VAL A 117ARG A 119 | NoneNoneNoneNoneADP A 301 (-3.6A) | 1.23A | 5f9zB-4k46A:undetectable | 5f9zB-4k46A:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lcb | CELL DIVISIONPROTEIN CDVC, VPS4 (Acidianushospitalis) |
PF00004(AAA)PF09336(Vps4_C) | 5 | LEU A 266SER A 346VAL A 347PRO A 136GLY A 242 | None | 1.32A | 5f9zB-4lcbA:undetectable | 5f9zB-4lcbA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qei | GLYCINE--TRNA LIGASE (Homo sapiens) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 5 | LEU A 135PRO A 244ARG A 277GLU A 296GLY A 406 | NoneNoneAMP A 701 (-2.9A)NoneAMP A 701 (-4.0A) | 0.90A | 5f9zB-4qeiA:23.6 | 5f9zB-4qeiA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ruh | CYTOSOLICNON-SPECIFICDIPEPTIDASE (Homo sapiens) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | LEU A 451VAL A 437PRO A 136SER A 30GLY A 164 | None | 1.37A | 5f9zB-4ruhA:undetectable | 5f9zB-4ruhA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4toq | CLASS III CHITINASE (Punica granatum) |
PF00704(Glyco_hydro_18) | 5 | LEU A 170PHE A 175VAL A 178PRO A 157GLY A 81 | None | 1.22A | 5f9zB-4toqA:undetectable | 5f9zB-4toqA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd9 | NISIN BIOSYNTHESISPROTEIN NISB (Lactococcuslactis) |
PF04738(Lant_dehydr_N)PF14028(Lant_dehydr_C) | 5 | GLU A 823VAL A 824GLU A 356PHE A 342GLY A 363 | None | 1.22A | 5f9zB-4wd9A:undetectable | 5f9zB-4wd9A:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9f | DOWN SYNDROME CELLADHESION MOLECULEISOFORM 6.9 (Drosophilamelanogaster) |
PF07679(I-set) | 5 | PHE A 245SER A 244VAL A 290PRO A 212GLY A 208 | GOL A 409 ( 4.8A)NoneNoneNoneSO4 A 411 ( 4.7A) | 1.37A | 5f9zB-4x9fA:undetectable | 5f9zB-4x9fA:20.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydq | PROLINE--TRNA LIGASE (Plasmodiumfalciparum) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 5 | GLU A 392ARG A 390GLU A 409SER A 508GLY A 510 | ANP A 801 (-3.6A)ANP A 801 ( 2.5A)HFG A 802 ( 4.9A)HFG A 802 ( 3.8A)HFG A 802 (-3.7A) | 1.30A | 5f9zB-4ydqA:51.0 | 5f9zB-4ydqA:57.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydq | PROLINE--TRNA LIGASE (Plasmodiumfalciparum) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 9 | LEU A 325GLU A 338VAL A 339PRO A 358ARG A 390GLU A 409PHE A 454SER A 508GLY A 510 | None MG A 803 ( 4.1A)HFG A 802 (-4.1A)HFG A 802 (-4.2A)ANP A 801 ( 2.5A)HFG A 802 ( 4.9A)HFG A 802 (-3.6A)HFG A 802 ( 3.8A)HFG A 802 (-3.7A) | 0.35A | 5f9zB-4ydqA:51.0 | 5f9zB-4ydqA:57.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydq | PROLINE--TRNA LIGASE (Plasmodiumfalciparum) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 9 | LEU A 325GLU A 338VAL A 339PRO A 358ARG A 390TRP A 407PHE A 454SER A 508GLY A 510 | None MG A 803 ( 4.1A)HFG A 802 (-4.1A)HFG A 802 (-4.2A)ANP A 801 ( 2.5A)NoneHFG A 802 (-3.6A)HFG A 802 ( 3.8A)HFG A 802 (-3.7A) | 0.67A | 5f9zB-4ydqA:51.0 | 5f9zB-4ydqA:57.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoh | PUTATIVEOXIDOREDUCTASEMOLYBDOPTERIN-BINDING SUBUNIT (Sulfurisphaeratokodaii) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | PHE A 181SER A 183ARG A 168PHE A 36GLY A 77 | None | 1.27A | 5f9zB-4zohA:undetectable | 5f9zB-4zohA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zyj | DNMZ (Streptomycespeucetius) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | LEU A 166PHE A 230VAL A 202PRO A 200GLY A 244 | None | 1.35A | 5f9zB-4zyjA:undetectable | 5f9zB-4zyjA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cio | PYRROLOQUINOLINEQUINONE BIOSYNTHESISPROTEIN PQQF (Serratia sp.FS14) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 5 | LEU A 562VAL A 612PRO A 628PHE A 669GLY A 636 | None | 1.21A | 5f9zB-5cioA:undetectable | 5f9zB-5cioA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czw | MYROILYSIN (Myroidesprofundi) |
PF01400(Astacin) | 5 | LEU A 7PRO A 92PHE A 144SER A 106GLY A 109 | None | 1.16A | 5f9zB-5czwA:undetectable | 5f9zB-5czwA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxl | TREHALOSE-6-PHOSPHATE PHOSPHATASE (Aspergillusfumigatus) |
PF02358(Trehalose_PPase) | 5 | GLU A 171VAL A 170PRO A 183SER A 84GLY A 65 | None | 1.34A | 5f9zB-5dxlA:3.7 | 5f9zB-5dxlA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0q | BETA-GLUCURONIDASE (Acidobacteriumcapsulatum) |
PF03662(Glyco_hydro_79n) | 5 | LEU A 176GLU A 245GLU A 45SER A 43GLY A 328 | NoneNoneIF6 A1476 (-2.9A)NoneNone | 1.28A | 5f9zB-5g0qA:undetectable | 5f9zB-5g0qA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gkq | ALYGC MUTANT - R241A (Paraglaciecolachathamensis) |
PF14592(Chondroitinas_B) | 5 | VAL A 431PRO A 429TRP A 427PHE A 60GLY A 78 | None | 1.06A | 5f9zB-5gkqA:undetectable | 5f9zB-5gkqA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 5 | LEU A 483SER A 479VAL A 331PRO A 329SER A 137 | NoneNone1VU A 601 ( 4.2A)1VU A 601 (-4.6A)None | 1.37A | 5f9zB-5jfmA:3.4 | 5f9zB-5jfmA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mih | PA-I GALACTOPHILICLECTIN (Pseudomonasaeruginosa) |
no annotation | 5 | LEU A 65PHE A 112SER A 111GLU A 5VAL A 6 | None | 1.33A | 5f9zB-5mihA:undetectable | 5f9zB-5mihA:11.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ngk | GLUCOSYLCERAMIDASE (Bacteroidesthetaiotaomicron) |
PF02055(Glyco_hydro_30)PF17189(Glyco_hydro_30C) | 5 | LEU A 381SER A 341GLU A 339GLU A 153GLY A 128 | None | 1.32A | 5f9zB-5ngkA:undetectable | 5f9zB-5ngkA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5svd | NUCLEOLAR PROTEIN 9 (Saccharomycescerevisiae) |
PF00806(PUF) | 5 | LEU A 213PHE A 258SER A 257PHE A 126GLY A 131 | LEU A 213 ( 0.6A)PHE A 258 ( 1.3A)SER A 257 ( 0.0A)PHE A 126 ( 1.3A)GLY A 131 ( 0.0A) | 1.08A | 5f9zB-5svdA:undetectable | 5f9zB-5svdA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sy5 | ARYL HYDROCARBONRECEPTOR NUCLEARTRANSLOCATORNEURONAL PASDOMAIN-CONTAININGPROTEIN 1 (Mus musculus;Mus musculus) |
PF00010(HLH)PF00989(PAS)PF14598(PAS_11)PF00010(HLH)PF00989(PAS)PF08447(PAS_3) | 5 | LEU A 408PHE A 427VAL A 425PHE A 363GLY B 345 | None | 1.17A | 5f9zB-5sy5A:undetectable | 5f9zB-5sy5A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ttk | AMINE OXIDASE (Pseudomonasputida) |
PF01593(Amino_oxidase) | 5 | LEU A 322PHE A 318GLU A 476SER A 469GLY A 474 | None | 1.09A | 5f9zB-5ttkA:undetectable | 5f9zB-5ttkA:19.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vad | BIFUNCTIONALGLUTAMATE/PROLINE--TRNA LIGASE (Homo sapiens) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 9 | LEU A1087GLU A1100VAL A1101PRO A1120ARG A1152TRP A1169GLU A1171SER A1272GLY A1274 | NoneNoneNoneNonePRO A1602 ( 3.4A)NonePRO A1602 ( 4.7A)PRO A1602 (-3.3A)PRO A1602 (-3.7A) | 0.77A | 5f9zB-5vadA:48.4 | 5f9zB-5vadA:54.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vad | BIFUNCTIONALGLUTAMATE/PROLINE--TRNA LIGASE (Homo sapiens) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 8 | LEU A1087VAL A1101PRO A1120TRP A1169GLU A1171PHE A1216SER A1272GLY A1274 | NoneNoneNoneNonePRO A1602 ( 4.7A)PRO A1602 (-4.3A)PRO A1602 (-3.3A)PRO A1602 (-3.7A) | 0.72A | 5f9zB-5vadA:48.4 | 5f9zB-5vadA:54.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgu | RIBONUCLEASE R (Escherichiacoli) |
no annotation | 5 | LEU B 585PHE B 574SER B 567SER B 84GLY B 5 | None | 1.34A | 5f9zB-5xguB:undetectable | 5f9zB-5xguB:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xii | PROLYL-TRNASYNTHETASE (PRORS) (Toxoplasmagondii) |
no annotation | 6 | GLU A 472ARG A 470TRP A 487GLU A 489SER A 588GLY A 590 | ANP A1001 (-3.4A)ANP A1001 ( 2.9A)NoneNone86X A1004 (-3.6A)86X A1004 ( 4.2A) | 1.29A | 5f9zB-5xiiA:51.9 | 5f9zB-5xiiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xii | PROLYL-TRNASYNTHETASE (PRORS) (Toxoplasmagondii) |
no annotation | 10 | LEU A 405GLU A 418VAL A 419PRO A 438ARG A 470TRP A 487GLU A 489PHE A 534SER A 588GLY A 590 | None MG A1003 (-4.1A)86X A1004 (-4.2A)86X A1004 (-4.3A)ANP A1001 ( 2.9A)NoneNone86X A1004 (-3.6A)86X A1004 (-3.6A)86X A1004 ( 4.2A) | 0.28A | 5f9zB-5xiiA:51.9 | 5f9zB-5xiiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xii | PROLYL-TRNASYNTHETASE (PRORS) (Toxoplasmagondii) |
no annotation | 6 | LEU A 405SER A 416VAL A 419GLU A 489PHE A 534SER A 588 | NoneNone86X A1004 (-4.2A)None86X A1004 (-3.6A)86X A1004 (-3.6A) | 1.20A | 5f9zB-5xiiA:51.9 | 5f9zB-5xiiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xil | PUTATIVE PROLYL-TRNASYNTHETASE (Leishmaniamajor) |
no annotation | 5 | TRP A 407GLU A 409PHE A 454SER A 510GLY A 512 | None | 0.43A | 5f9zB-5xilA:46.7 | 5f9zB-5xilA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xio | PROLINE-TRNASYNTHETASE CLASS IIAARS (YBAK RNABINDING DOMAIN PLUSTRNA SYNTHETASE) (Cryptosporidiumparvum) |
no annotation | 6 | GLU A 364ARG A 362TRP A 379GLU A 381SER A 480GLY A 482 | ANP A 803 (-3.7A)ANP A 803 ( 3.1A)NoneHFG A 801 ( 4.9A)HFG A 801 ( 3.8A)HFG A 801 (-3.9A) | 1.30A | 5f9zB-5xioA:51.6 | 5f9zB-5xioA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xio | PROLINE-TRNASYNTHETASE CLASS IIAARS (YBAK RNABINDING DOMAIN PLUSTRNA SYNTHETASE) (Cryptosporidiumparvum) |
no annotation | 8 | LEU A 297GLU A 310VAL A 311PRO A 330ARG A 362PHE A 426SER A 480GLY A 482 | NoneNoneHFG A 801 (-4.3A)HFG A 801 ( 4.8A)ANP A 803 ( 3.1A)HFG A 801 (-3.7A)HFG A 801 ( 3.8A)HFG A 801 (-3.9A) | 0.64A | 5f9zB-5xioA:51.6 | 5f9zB-5xioA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xio | PROLINE-TRNASYNTHETASE CLASS IIAARS (YBAK RNABINDING DOMAIN PLUSTRNA SYNTHETASE) (Cryptosporidiumparvum) |
no annotation | 9 | LEU A 297VAL A 311PRO A 330ARG A 362TRP A 379GLU A 381PHE A 426SER A 480GLY A 482 | NoneHFG A 801 (-4.3A)HFG A 801 ( 4.8A)ANP A 803 ( 3.1A)NoneHFG A 801 ( 4.9A)HFG A 801 (-3.7A)HFG A 801 ( 3.8A)HFG A 801 (-3.9A) | 0.30A | 5f9zB-5xioA:51.6 | 5f9zB-5xioA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xip | PROLYL-TRNASYNTHETASE, PUTATIVE (Eimeria tenella) |
no annotation | 6 | GLU A 392ARG A 390TRP A 407GLU A 409SER A 508GLY A 510 | ANP A1001 (-3.8A)ANP A1001 (-2.8A)HFG A1003 (-4.7A)HFG A1003 ( 4.8A)HFG A1003 ( 3.9A)HFG A1003 ( 3.9A) | 1.20A | 5f9zB-5xipA:50.8 | 5f9zB-5xipA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xip | PROLYL-TRNASYNTHETASE, PUTATIVE (Eimeria tenella) |
no annotation | 10 | LEU A 325GLU A 338VAL A 339PRO A 358ARG A 390TRP A 407GLU A 409PHE A 454SER A 508GLY A 510 | None MG A1002 ( 4.3A)HFG A1003 ( 4.6A)HFG A1003 (-4.3A)ANP A1001 (-2.8A)HFG A1003 (-4.7A)HFG A1003 ( 4.8A)HFG A1003 (-3.4A)HFG A1003 ( 3.9A)HFG A1003 ( 3.9A) | 0.35A | 5f9zB-5xipA:50.8 | 5f9zB-5xipA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fpc | PRO-PROENDOPEPTIDASE (Paenibacillusalvei) |
no annotation | 5 | PHE A 183SER A 152GLU A 150VAL A 151GLY A 71 | None | 1.28A | 5f9zB-6fpcA:undetectable | 5f9zB-6fpcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | ANTHRANILATESYNTHASE (Serratiamarcescens) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 4 | THR A 425GLU A 309THR A 329HIS A 398 | BEZ A1501 (-4.7A)BEZ A1501 (-3.8A)BEZ A1501 (-3.9A)BEZ A1501 ( 4.2A) | 1.37A | 5f9zB-1i7qA:1.0 | 5f9zB-1i7qA:19.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nj1 | PROLINE-TRNASYNTHETASE (Methanothermobacterthermautotrophicus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | THR A 117GLU A 119THR A 235HIS A 237 | 5CA A 512 (-3.5A)5CA A 512 (-3.0A)5CA A 512 (-3.0A)5CA A 512 (-4.4A) | 0.52A | 5f9zB-1nj1A:42.9 | 5f9zB-1nj1A:35.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nj8 | PROLINE-TRNASYNTHETASE (Methanocaldococcusjannaschii) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09181(ProRS-C_2) | 4 | THR A 101GLU A 103THR A 219HIS A 221 | None | 0.78A | 5f9zB-1nj8A:41.6 | 5f9zB-1nj8A:36.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdl | PROTEIN(ANTHRANILATESYNTHASE(TRPE-SUBUNIT)) (Sulfolobussolfataricus) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 4 | THR A 333GLU A 225THR A 243HIS A 306 | None | 1.39A | 5f9zB-1qdlA:undetectable | 5f9zB-1qdlA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hih | LIPASE 46 KDA FORM (Staphylococcushyicus) |
no annotation | 4 | THR A 261GLU A 328THR A 172HIS A 177 | None | 1.26A | 5f9zB-2hihA:0.3 | 5f9zB-2hihA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfm | ADENYLOSUCCINATELYASE (Bacillusanthracis) |
PF00206(Lyase_1)PF10397(ADSL_C) | 4 | THR A 250GLU A 252THR A 350HIS A 146 | None | 1.40A | 5f9zB-2pfmA:0.0 | 5f9zB-2pfmA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7t | ENVELOPE PROTEIN (Dengue virus) |
PF00869(Flavi_glycoprot)PF02832(Flavi_glycop_C) | 4 | THR A 353GLU A 26THR A 315HIS A 317 | None | 1.33A | 5f9zB-3g7tA:undetectable | 5f9zB-3g7tA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r75 | ANTHRANILATE/PARA-AMINOBENZOATESYNTHASES COMPONENTI (Burkholderialata) |
PF00117(GATase)PF00425(Chorismate_bind) | 4 | THR A 304GLU A 201THR A 219HIS A 279 | BEZ A 701 (-4.7A)BEZ A 701 ( 4.3A)BEZ A 701 (-4.0A)BEZ A 701 (-3.8A) | 1.45A | 5f9zB-3r75A:undetectable | 5f9zB-3r75A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rao | PUTATIVELUCIFERASE-LIKEMONOOXYGENASE (Bacillus cereus) |
PF00296(Bac_luciferase) | 4 | THR A 66GLU A 63THR A 94HIS A 89 | None | 1.20A | 5f9zB-3raoA:0.8 | 5f9zB-3raoA:23.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydq | PROLINE--TRNA LIGASE (Plasmodiumfalciparum) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | THR A 359GLU A 361THR A 478HIS A 480 | HFG A 802 (-3.2A)HFG A 802 (-2.9A)HFG A 802 ( 4.0A)HFG A 802 (-4.0A) | 0.39A | 5f9zB-4ydqA:51.0 | 5f9zB-4ydqA:57.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwa | ANTHRANILATESYNTHASE COMPONENT 1 (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 4 | THR A 415GLU A 307THR A 325HIS A 388 | None0GA A 604 ( 4.5A)0GA A 604 ( 4.6A)0GA A 604 ( 4.3A) | 1.43A | 5f9zB-5cwaA:undetectable | 5f9zB-5cwaA:19.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vad | BIFUNCTIONALGLUTAMATE/PROLINE--TRNA LIGASE (Homo sapiens) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | THR A1121GLU A1123THR A1240HIS A1242 | PRO A1602 (-3.5A)PRO A1602 (-2.8A)91Y A1601 (-4.2A)PRO A1602 (-4.1A) | 0.52A | 5f9zB-5vadA:48.4 | 5f9zB-5vadA:54.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vvr | DNA REPAIR ANDRECOMBINATIONPROTEIN RAD26 (Saccharomycescerevisiae) |
no annotation | 4 | THR M 506GLU M 507THR M 499HIS M 472 | None | 1.31A | 5f9zB-5vvrM:undetectable | 5f9zB-5vvrM:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xii | PROLYL-TRNASYNTHETASE (PRORS) (Toxoplasmagondii) |
no annotation | 4 | THR A 439GLU A 441THR A 558HIS A 560 | 86X A1004 (-3.6A)86X A1004 (-3.0A)86X A1004 (-3.9A)86X A1004 (-3.7A) | 0.24A | 5f9zB-5xiiA:51.9 | 5f9zB-5xiiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xio | PROLINE-TRNASYNTHETASE CLASS IIAARS (YBAK RNABINDING DOMAIN PLUSTRNA SYNTHETASE) (Cryptosporidiumparvum) |
no annotation | 4 | THR A 331GLU A 333THR A 450HIS A 452 | HFG A 801 (-3.4A)HFG A 801 (-3.0A)ANP A 803 (-3.9A)HFG A 801 (-4.2A) | 0.52A | 5f9zB-5xioA:51.6 | 5f9zB-5xioA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xip | PROLYL-TRNASYNTHETASE, PUTATIVE (Eimeria tenella) |
no annotation | 4 | THR A 359GLU A 361THR A 478HIS A 480 | HFG A1003 (-3.9A)HFG A1003 (-2.9A)ANP A1001 ( 3.7A)HFG A1003 (-3.5A) | 0.41A | 5f9zB-5xipA:50.8 | 5f9zB-5xipA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk8 | PRE-MRNA-SPLICINGFACTOR SYF1 (Saccharomycescerevisiae) |
no annotation | 4 | THR U 796GLU U 788THR U 758HIS U 791 | None | 1.33A | 5f9zB-6bk8U:undetectable | 5f9zB-6bk8U:undetectable |