SIMILAR PATTERNS OF AMINO ACIDS FOR 5F1A_B_SALB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a87 COLICIN N

(Escherichia
coli) 		PF01024
(Colicin) 		4 LEU A 366
GLY A 339
ALA A 340
SER A 343
 None
 0.56A 5f1aB-1a87A:
0.0		 5f1aB-1a87A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b33 ALLOPHYCOCYANIN,
ALPHA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		4 LEU A  84
GLY A 128
ALA A 127
SER A 130
 BLA  A 201 ( 4.7A)
None
None
None
 0.82A 5f1aB-1b33A:
undetectable		 5f1aB-1b33A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 VAL A  95
LEU A 372
GLY A 345
ALA A 344
 None
 0.91A 5f1aB-1bvuA:
undetectable		 5f1aB-1bvuA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A 287
TYR A 284
GLY A 211
ALA A 210
 None
 0.74A 5f1aB-1bxkA:
undetectable		 5f1aB-1bxkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 107
TYR A 195
GLY A 412
ALA A 413
 None
 0.71A 5f1aB-1cg2A:
undetectable		 5f1aB-1cg2A:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 349
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
 SCL  A 700 ( 4.6A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.26A 5f1aB-1ebvA:
31.9		 5f1aB-1ebvA:
63.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 LEU A  43
TYR A 107
GLY A  87
ALA A  86
 None
 0.69A 5f1aB-1httA:
0.0		 5f1aB-1httA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 VAL A 132
LEU A  84
TYR A  80
ALA A 118
 None
 0.82A 5f1aB-1jctA:
0.0		 5f1aB-1jctA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfr LIPASE

(Streptomyces
exfoliatus) 		PF03403
(PAF-AH_p_II) 		4 LEU A 165
TRP A 162
ALA A 140
SER A 143
 None
 0.87A 5f1aB-1jfrA:
0.0		 5f1aB-1jfrA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 LEU A 154
GLY A 138
ALA A 137
SER A 140
 None
None
FAD  A3000 (-3.5A)
None
 0.90A 5f1aB-1m64A:
0.0		 5f1aB-1m64A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		4 VAL A 495
LEU A 447
GLY A 378
ALA A 377
 MAY  A 600 (-4.8A)
None
None
MAY  A 600 (-3.7A)
 0.69A 5f1aB-1mt5A:
undetectable		 5f1aB-1mt5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		4 VAL X 257
GLY X 328
ALA X 329
SER X 330
 None
 0.91A 5f1aB-1pp1X:
undetectable		 5f1aB-1pp1X:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		4 VAL A 325
LEU A 312
GLY A  80
ALA A  81
 None
 0.91A 5f1aB-1sc6A:
undetectable		 5f1aB-1sc6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		4 LEU A 290
GLY A 215
ALA A 216
SER A 293
 None
 0.80A 5f1aB-1u6zA:
undetectable		 5f1aB-1u6zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 VAL A 101
LEU A  23
GLY A 109
ALA A 110
 None
 0.90A 5f1aB-1uiyA:
undetectable		 5f1aB-1uiyA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 LEU A 193
GLY A  78
ALA A  79
SER A  82
 None
 0.85A 5f1aB-1zg4A:
undetectable		 5f1aB-1zg4A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 VAL A 215
LEU A  74
GLY A 290
ALA A 289
 None
 0.69A 5f1aB-2elcA:
undetectable		 5f1aB-2elcA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 LEU A 610
GLY A 575
ALA A 574
SER A 577
 None
 0.82A 5f1aB-2g28A:
undetectable		 5f1aB-2g28A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j89 METHIONINE SULFOXIDE
REDUCTASE A

(Populus
trichocarpa) 		PF01625
(PMSR) 		4 LEU A 180
TYR A 179
TRP A  48
GLY A 204
 None
None
BME  A 207 ( 4.2A)
None
 0.72A 5f1aB-2j89A:
undetectable		 5f1aB-2j89A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnn PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF01047
(MarR) 		4 LEU A  44
GLY A 102
ALA A 101
SER A  99
 None
 0.74A 5f1aB-2nnnA:
undetectable		 5f1aB-2nnnA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		4 LEU B1077
TYR B1071
GLY B1266
ALA B1265
 None
 0.82A 5f1aB-2nvuB:
undetectable		 5f1aB-2nvuB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0q HYPOTHETICAL PROTEIN
CC0527

(Caulobacter
vibrioides) 		PF06108
(DUF952) 		4 LEU A 113
GLY A  39
ALA A  38
SER A  37
 None
 0.88A 5f1aB-2o0qA:
undetectable		 5f1aB-2o0qA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		4 VAL A  89
LEU A 221
GLY A  23
ALA A  25
 None
 0.90A 5f1aB-2pd3A:
undetectable		 5f1aB-2pd3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  55
GLY A  92
ALA A  91
SER A  94
 None
 0.86A 5f1aB-2pozA:
0.4		 5f1aB-2pozA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 LEU A 221
GLY A 179
ALA A 178
SER A 181
 None
 0.82A 5f1aB-2qxlA:
2.2		 5f1aB-2qxlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r87 PURP PROTEIN PF1517

(Pyrococcus
furiosus) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 VAL A 229
TYR A 182
GLY A 291
ALA A 290
 None
None
None
PO4  A 402 (-3.6A)
 0.88A 5f1aB-2r87A:
undetectable		 5f1aB-2r87A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 LEU A 143
GLY A 662
ALA A 663
SER A 146
 None
 0.82A 5f1aB-2v26A:
undetectable		 5f1aB-2v26A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A 478
GLY A 357
ALA A 356
SER A 359
 None
 0.84A 5f1aB-2wpgA:
undetectable		 5f1aB-2wpgA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 LEU A 202
GLY A 255
ALA A 254
SER A 251
 None
 0.76A 5f1aB-3auoA:
undetectable		 5f1aB-3auoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		4 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.91A 5f1aB-3csgA:
undetectable		 5f1aB-3csgA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 LEU A 477
GLY A 356
ALA A 355
SER A 358
 None
 0.79A 5f1aB-3czeA:
0.4		 5f1aB-3czeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9w PUTATIVE
ACETYLTRANSFERASE

(Nocardia
farcinica) 		PF00797
(Acetyltransf_2) 		4 VAL A 137
LEU A  16
TYR A  21
ALA A  90
 None
 0.87A 5f1aB-3d9wA:
undetectable		 5f1aB-3d9wA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8w LACTOCOCCAL PROPHAGE
PS3 PROTEIN 05

(Staphylococcus
epidermidis) 		PF13420
(Acetyltransf_4) 		4 VAL A  88
LEU A   7
GLY A  56
ALA A  57
 NHE  A 167 ( 4.8A)
None
None
None
 0.90A 5f1aB-3g8wA:
undetectable		 5f1aB-3g8wA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Dermatophagoides
pteronyssinus;
Escherichia
coli) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		4 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.91A 5f1aB-3h4zA:
undetectable		 5f1aB-3h4zA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 VAL A 129
TYR A 316
GLY A 136
ALA A 137
 None
 0.66A 5f1aB-3hlmA:
undetectable		 5f1aB-3hlmA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb5 MAJOR CAPSID PROTEIN

(Propionibacterium
virus PA6) 		no annotation 4 LEU A 122
GLY A 229
ALA A 230
SER A 225
 None
 0.79A 5f1aB-3jb5A:
undetectable		 5f1aB-3jb5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldz SIGNAL TRANSDUCING
ADAPTER MOLECULE 1

(Homo sapiens) 		PF00790
(VHS) 		4 LEU A 111
GLY A  70
ALA A  71
SER A  74
 None
 0.56A 5f1aB-3ldzA:
undetectable		 5f1aB-3ldzA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq9 BONE MARROW STROMAL
ANTIGEN 2 FUSED TO
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16716
(BST2) 		4 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.89A 5f1aB-3mq9A:
undetectable		 5f1aB-3mq9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtt PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA

(Homo sapiens) 		PF16454
(PI3K_P85_iSH2) 		4 LEU A 581
TRP A 580
GLY A 443
ALA A 444
 None
 0.84A 5f1aB-3mttA:
undetectable		 5f1aB-3mttA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A  62
GLY A 125
ALA A 124
SER A 127
 None
None
EDO  A 235 (-4.3A)
None
 0.81A 5f1aB-3mvuA:
undetectable		 5f1aB-3mvuA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 LEU A-272
GLY A -83
ALA A -84
SER A -85
 None
 0.92A 5f1aB-3n94A:
undetectable		 5f1aB-3n94A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A  30
GLY A  12
ALA A  11
SER A  14
 None
None
FAD  A 500 (-3.3A)
None
 0.77A 5f1aB-3oc4A:
undetectable		 5f1aB-3oc4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 LEU A 108
GLY A 171
ALA A 172
SER A 175
 None
 0.80A 5f1aB-3pxxA:
undetectable		 5f1aB-3pxxA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8x METHIONYL-TRNA
FORMYLTRANSFERASE

(Yersinia pestis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 LEU A  55
GLY A  21
ALA A  22
SER A  25
 None
 0.64A 5f1aB-3r8xA:
undetectable		 5f1aB-3r8xA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		4 LEU A  80
TYR A  73
GLY A 127
ALA A 126
 None
 0.80A 5f1aB-3t33A:
undetectable		 5f1aB-3t33A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		4 VAL A 145
LEU A 283
GLY A  44
SER A  42
 None
 0.74A 5f1aB-3ufgA:
undetectable		 5f1aB-3ufgA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		4 LEU A 584
GLY A 493
ALA A 494
SER A 497
 None
 0.62A 5f1aB-3v94A:
undetectable		 5f1aB-3v94A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 LEU A  93
GLY A 164
ALA A 165
SER A 168
 None
 0.87A 5f1aB-3x0yA:
undetectable		 5f1aB-3x0yA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9w MONOOXYGENASE

(Stenotrophomonas
maltophilia) 		PF13738
(Pyr_redox_3) 		5 VAL A 336
LEU A  91
TYR A  85
GLY A  19
ALA A  18
 None
 1.12A 5f1aB-4a9wA:
undetectable		 5f1aB-4a9wA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		4 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.86A 5f1aB-4b3nA:
undetectable		 5f1aB-4b3nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 LEU A 463
TYR A 466
GLY A 460
ALA A 459
 None
 0.79A 5f1aB-4bugA:
undetectable		 5f1aB-4bugA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 TYR A 247
GLY A 216
ALA A 218
SER A 220
 None
KCX  A 219 ( 4.5A)
KCX  A 219 ( 3.1A)
KCX  A 219 ( 4.3A)
 0.91A 5f1aB-4c13A:
undetectable		 5f1aB-4c13A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.84A 5f1aB-4dxbA:
0.0		 5f1aB-4dxbA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575) 		PF00201
(UDPGT)
PF06722
(DUF1205) 		4 LEU A 119
GLY A 149
ALA A 148
SER A 147
 None
 0.87A 5f1aB-4g2tA:
undetectable		 5f1aB-4g2tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g92 HAPE
TRANSCRIPTION FACTOR
HAPC (EUROFUNG)

(Aspergillus
nidulans) 		PF00808
(CBFD_NFYB_HMF) 		5 LEU B 127
TYR B 130
GLY B 104
ALA C 109
SER C 106
 None
 1.48A 5f1aB-4g92B:
undetectable		 5f1aB-4g92B:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		4 LEU A  77
GLY A 266
ALA A 265
SER A 264
 None
 0.90A 5f1aB-4gizA:
undetectable		 5f1aB-4gizA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqb SINGLE-STRANDED
DNA-BINDING PROTEIN
DDRB

(Deinococcus
radiodurans) 		PF12747
(DdrB) 		4 VAL A 115
TYR A  82
GLY A 106
ALA A 107
 None
 0.75A 5f1aB-4hqbA:
undetectable		 5f1aB-4hqbA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2a HALOALKANE
DEHALOGENASE

(Bradyrhizobium
elkanii) 		PF00561
(Abhydrolase_1) 		4 LEU A 273
GLY A 269
ALA A 268
SER A 241
 None
 0.89A 5f1aB-4k2aA:
undetectable		 5f1aB-4k2aA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjr CATION EXCHANGER
YFKE

(Bacillus
subtilis) 		PF01699
(Na_Ca_ex) 		4 LEU A 338
GLY A 105
ALA A 104
SER A 107
 None
 0.84A 5f1aB-4kjrA:
0.4		 5f1aB-4kjrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		4 VAL D 183
LEU D 252
GLY D 223
ALA D 224
 None
 0.90A 5f1aB-4mwaD:
undetectable		 5f1aB-4mwaD:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 LEU A 171
GLY A  57
ALA A  58
SER A 210
 None
 0.72A 5f1aB-4om9A:
undetectable		 5f1aB-4om9A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pde PROTEIN FDHD

(Escherichia
coli) 		PF02634
(FdhD-NarQ) 		4 VAL A 214
LEU A 139
GLY A 232
SER A 228
 None
 0.90A 5f1aB-4pdeA:
undetectable		 5f1aB-4pdeA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 350
LEU A 385
TYR A 386
TRP A 388
GLY A 527
ALA A 528
 IBP  A 601 (-4.3A)
None
IBP  A 601 (-4.8A)
None
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
 0.17A 5f1aB-4ph9A:
63.4		 5f1aB-4ph9A:
88.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 VAL A 350
TYR A 386
TRP A 388
ALA A 528
SER A 531
 IBP  A 601 (-4.3A)
IBP  A 601 (-4.8A)
None
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
 0.64A 5f1aB-4ph9A:
63.4		 5f1aB-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqk MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
TRUNCATED
REPLICATION PROTEIN
REPA

(Escherichia
coli;
Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		4 LEU A  77
GLY A 266
ALA A 265
SER A 264
 None
 0.89A 5f1aB-4pqkA:
undetectable		 5f1aB-4pqkA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		4 LEU A-295
GLY A-106
ALA A-107
SER A-108
 None
 0.89A 5f1aB-4qszA:
undetectable		 5f1aB-4qszA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		4 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.88A 5f1aB-4r0yA:
undetectable		 5f1aB-4r0yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		4 VAL A 174
LEU A 258
GLY A 110
ALA A 111
 None
 0.70A 5f1aB-4rkcA:
undetectable		 5f1aB-4rkcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN A CHAIN
GLOBIN B CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		4 VAL B   5
LEU A  68
GLY A  34
ALA A  35
 None
 0.84A 5f1aB-4u8uB:
undetectable		 5f1aB-4u8uB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 VAL A 105
TYR A 294
GLY A 112
ALA A 113
 None
CSO  A 296 ( 4.6A)
None
None
 0.70A 5f1aB-4wb0A:
undetectable		 5f1aB-4wb0A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 VAL A 184
LEU A 269
GLY A 117
ALA A 118
 None
 0.57A 5f1aB-4wb0A:
undetectable		 5f1aB-4wb0A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwv AMINOPEPTIDASE FROM
FAMILY M42

(Desulfurococcus
amylolyticus) 		PF05343
(Peptidase_M42) 		4 VAL A 209
GLY A 220
ALA A 221
SER A 224
 None
 0.83A 5f1aB-4wwvA:
undetectable		 5f1aB-4wwvA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT

(Caldanaerobacter
subterraneus) 		no annotation 4 LEU D  25
GLY D  91
ALA D  90
SER D  93
 None
 0.77A 5f1aB-4ymwD:
undetectable		 5f1aB-4ymwD:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI

(Saccharomyces
cerevisiae) 		PF03161
(LAGLIDADG_2) 		4 LEU A 412
GLY A 337
ALA A 336
SER A 437
 None
 0.89A 5f1aB-5a0mA:
undetectable		 5f1aB-5a0mA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a12 CHLORITE DISMUTASE

(Magnetospirillum
sp.) 		PF06778
(Chlor_dismutase) 		4 LEU A 175
GLY A 130
ALA A 129
SER A 132
 HEM  A 250 ( 4.7A)
None
None
None
 0.72A 5f1aB-5a12A:
undetectable		 5f1aB-5a12A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 LEU A1405
GLY A1467
ALA A1468
SER A1471
 None
 0.77A 5f1aB-5a31A:
undetectable		 5f1aB-5a31A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		4 LEU A 120
GLY A 251
ALA A 250
SER A 249
 None
 0.90A 5f1aB-5aexA:
undetectable		 5f1aB-5aexA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		4 LEU A 323
GLY A 208
ALA A 209
SER A 212
 None
 0.85A 5f1aB-5aqaA:
undetectable		 5f1aB-5aqaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.91A 5f1aB-5azaA:
undetectable		 5f1aB-5azaA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpg (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF01575
(MaoC_dehydratas) 		4 LEU A  88
GLY A  65
ALA A  66
SER A  69
 None
 0.56A 5f1aB-5cpgA:
undetectable		 5f1aB-5cpgA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 LEU A  43
TYR A 109
GLY A  89
ALA A  88
 None
 0.77A 5f1aB-5e3iA:
undetectable		 5f1aB-5e3iA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 VAL A 390
LEU A 507
GLY A 358
ALA A 359
 None
 0.86A 5f1aB-5ez3A:
undetectable		 5f1aB-5ez3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7t CLASS IV CHITINASE

(Cryptomeria
japonica) 		no annotation 4 LEU A 124
GLY A 113
ALA A 114
SER A 117
 None
 0.55A 5f1aB-5h7tA:
undetectable		 5f1aB-5h7tA:
15.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 VAL A 349
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
 ID8  A 601 (-3.9A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.18A 5f1aB-5ikrA:
63.6		 5f1aB-5ikrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13407
(Peripla_BP_4) 		4 VAL A 185
LEU A 223
GLY A 253
ALA A 254
 None
 0.86A 5f1aB-5ix8A:
undetectable		 5f1aB-5ix8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU B 635
GLY B 598
ALA B 599
SER B 602
 None
 0.87A 5f1aB-5l3qB:
undetectable		 5f1aB-5l3qB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 LEU B 281
GLY B 297
ALA B 298
SER B 301
 None
 0.51A 5f1aB-5l3xB:
undetectable		 5f1aB-5l3xB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 LEU A1405
GLY A1467
ALA A1468
SER A1471
 None
 0.80A 5f1aB-5lcwA:
undetectable		 5f1aB-5lcwA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE

(Pyrococcus
furiosus) 		PF00535
(Glycos_transf_2)
PF04138
(GtrA) 		4 VAL A 156
GLY A 137
ALA A 138
SER A 135
 None
 0.86A 5f1aB-5mlzA:
undetectable		 5f1aB-5mlzA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 4 VAL A 347
LEU A 315
GLY A 331
ALA A 332
 None
 0.91A 5f1aB-5od2A:
undetectable		 5f1aB-5od2A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojr -

(-) 		no annotation 4 LEU A 273
TYR A 316
GLY A 288
ALA A 289
 None
 0.88A 5f1aB-5ojrA:
undetectable		 5f1aB-5ojrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 LEU A 705
TYR A 703
GLY A 693
ALA A 685
 None
 0.87A 5f1aB-5szsA:
1.2		 5f1aB-5szsA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 VAL A   6
LEU A  78
TYR A  74
GLY A  24
 None
 0.71A 5f1aB-5u03A:
undetectable		 5f1aB-5u03A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 4 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.92A 5f1aB-5vawA:
undetectable		 5f1aB-5vawA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 4 VAL A 141
LEU A 137
TYR A 223
GLY A 117
 FAD  A 601 ( 3.8A)
None
None
FAD  A 601 (-4.4A)
 0.69A 5f1aB-5w1jA:
undetectable		 5f1aB-5w1jA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 4 LEU A  80
GLY A  64
ALA A  63
SER A  66
 None
None
FAD  A 604 (-3.5A)
None
 0.88A 5f1aB-5z2gA:
undetectable		 5f1aB-5z2gA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 VAL A 160
GLY A 559
ALA A 560
SER A 156
 None
 0.87A 5f1aB-5zl9A:
0.0		 5f1aB-5zl9A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.89A 5f1aB-6apxA:
undetectable		 5f1aB-6apxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE

(Homo sapiens) 		no annotation 4 LEU A 384
GLY A 196
ALA A 195
SER A 198
 None
 0.77A 5f1aB-6fm9A:
undetectable		 5f1aB-6fm9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 4 LEU A 101
TYR A  98
GLY A 113
ALA A 114
 None
 0.67A 5f1aB-6g21A:
undetectable		 5f1aB-6g21A:
10.31