SIMILAR PATTERNS OF AMINO ACIDS FOR 5EYP_B_LOCB502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 128
LEU A 319
THR A 301
ALA A 287
ILE A 274
 None
 1.17A 5eypB-1bkhA:
3.6		 5eypB-1bkhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpc C-PHYCOCYANIN (BETA
SUBUNIT)

(Microchaete
diplosiphon) 		PF00502
(Phycobilisome) 		5 LEU B 107
ALA B 169
ILE B  99
ALA B  98
ILE B  44
 None
 0.98A 5eypB-1cpcB:
undetectable		 5eypB-1cpcB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 LEU A 259
ASN A 209
ALA A 207
ILE A 203
ILE A 167
 None
 1.25A 5eypB-1dysA:
undetectable		 5eypB-1dysA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A 103
ALA A  83
ILE A  78
LYS A  58
ALA A  60
 None
 0.77A 5eypB-1h6uA:
undetectable		 5eypB-1h6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF00483
(NTP_transferase) 		5 LEU A  76
LEU A  68
ILE A  10
ALA A 106
ILE A  43
 None
None
None
CDC  A1991 (-3.6A)
None
 1.01A 5eypB-1jylA:
undetectable		 5eypB-1jylA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4n PROTEIN EC4020

(Escherichia
coli) 		PF06185
(YecM) 		5 ALA A  93
LEU A  28
ILE A 120
ALA A  44
ILE A 175
 None
 1.28A 5eypB-1k4nA:
undetectable		 5eypB-1k4nA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 LEU A 286
ALA A 259
ASN A 254
ALA A 234
ILE A 231
 None
 0.83A 5eypB-1l8wA:
undetectable		 5eypB-1l8wA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		5 LEU E 951
ALA E1002
LEU E 915
ILE E 990
ALA E 988
 None
 1.02A 5eypB-1o7dE:
undetectable		 5eypB-1o7dE:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 CYH A 929
LEU A 926
ALA A 889
LEU A 885
ILE A 806
 None
 1.05A 5eypB-1sojA:
undetectable		 5eypB-1sojA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		5 ALA A 149
LEU A 147
ALA A 107
ILE A  69
ALA A  91
 None
 0.84A 5eypB-1ur4A:
3.0		 5eypB-1ur4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ALA A 128
ALA A  78
ILE A  75
LYS A  53
ALA A  57
 None
 1.01A 5eypB-1vdkA:
undetectable		 5eypB-1vdkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)
PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3)
no annotation 		5 LEU P  18
ALA P  14
THR A 447
ILE P  37
ALA P  36
 None
 1.00A 5eypB-2btvP:
undetectable		 5eypB-2btvP:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 5 LEU P  18
ALA P  14
ASN P  28
ILE P  37
ALA P  36
 None
 1.21A 5eypB-2btvP:
undetectable		 5eypB-2btvP:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.26A 5eypB-2ffhA:
3.5		 5eypB-2ffhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24

(Trypanosoma
brucei) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 LEU A 150
LEU A 152
ASN A 177
ALA A 172
ILE A 169
 None
 1.20A 5eypB-2lvvA:
undetectable		 5eypB-2lvvA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.30A 5eypB-2ng1A:
undetectable		 5eypB-2ng1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 LEU A 288
ALA A 189
LEU A 191
THR A 196
ILE A 232
 None
None
None
NAP  A 402 (-3.3A)
NAP  A 402 ( 4.8A)
 1.14A 5eypB-2o7pA:
undetectable		 5eypB-2o7pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 THR A 329
ALA A 303
LYS A 304
ALA A 254
ILE A 280
 None
 1.24A 5eypB-2odlA:
undetectable		 5eypB-2odlA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.85A 5eypB-2oi6A:
undetectable		 5eypB-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		5 LEU A1179
ALA A1113
ALA A1186
ILE A1208
ILE A1135
 None
 1.05A 5eypB-2p3vA:
undetectable		 5eypB-2p3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkq GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
B

(Spinacia
oleracea) 		PF00044
(Gp_dh_N)
PF02672
(CP12)
PF02800
(Gp_dh_C) 		5 LEU O 324
ALA O 122
ILE O 118
ALA O 120
ILE O 125
 None
None
None
NDP  O 363 ( 3.7A)
None
 1.25A 5eypB-2pkqO:
3.9		 5eypB-2pkqO:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 128
ALA A 387
LEU A 384
ALA A 353
ILE A 344
 None
 1.28A 5eypB-2ptzA:
undetectable		 5eypB-2ptzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 208
LEU A 151
THR A 127
ALA A 224
ILE A 185
 None
 0.79A 5eypB-2qo3A:
undetectable		 5eypB-2qo3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT

(Bacillus
subtilis) 		PF02302
(PTS_IIB) 		5 LEU A  97
ALA A   1
ILE A  60
LYS A  76
ALA A  96
 None
 1.19A 5eypB-2r48A:
2.4		 5eypB-2r48A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 167
LEU A  65
ALA A 123
ILE A 125
ILE A  76
 None
 0.84A 5eypB-2v7bA:
undetectable		 5eypB-2v7bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wiz ARCHAEAL HJC

(Archaeoglobus
fulgidus) 		PF01870
(Hjc) 		5 ALA A  23
LEU A  48
ALA A 124
ILE A 120
ALA A  19
 None
 1.16A 5eypB-2wizA:
undetectable		 5eypB-2wizA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]

(Methanocaldococcus
jannaschii) 		PF13847
(Methyltransf_31) 		5 THR A 131
ALA A 129
ILE A 127
ALA A 181
ILE A 106
 None
 0.78A 5eypB-2yxdA:
3.1		 5eypB-2yxdA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		5 LEU A 419
LEU A 482
ASN A 466
ALA A 496
ILE A 617
 None
 1.18A 5eypB-2zj8A:
undetectable		 5eypB-2zj8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aty PROSTAGLANDIN F2A
SYNTHASE

(Trypanosoma
cruzi) 		PF00724
(Oxidored_FMN) 		5 LEU A  99
LEU A  11
ILE A  23
LYS A 310
ALA A 332
 None
 1.00A 5eypB-3atyA:
4.3		 5eypB-3atyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwq CAPSID PROTEIN VP1

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 CYH A  49
LEU A  51
THR A 218
ILE A  93
ALA A  91
 None
 1.11A 5eypB-3bwqA:
undetectable		 5eypB-3bwqA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 LEU A 374
ASN A 378
ALA A 358
ALA A 333
ILE A 360
 None
 0.99A 5eypB-3bz5A:
undetectable		 5eypB-3bz5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU A   9
ALA A  63
ILE A  65
ALA A  70
ILE A  32
 None
 0.67A 5eypB-3ctzA:
undetectable		 5eypB-3ctzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3k UNCHARACTERIZED
PROTEIN YKR043C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		5 LEU A  97
ALA A 175
ILE A 152
ALA A 151
ILE A 186
 None
 1.27A 5eypB-3f3kA:
undetectable		 5eypB-3f3kA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Rickettsia
prowazekii) 		PF13561
(adh_short_C2) 		5 LEU A 114
LEU A  70
ILE A  11
ALA A  14
ILE A  34
 None
 1.26A 5eypB-3f9iA:
7.3		 5eypB-3f9iA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU

(Yersinia pestis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.92A 5eypB-3fwwA:
undetectable		 5eypB-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		5 LEU A 275
LEU A 282
LEU A 266
THR A 214
ALA A 204
 None
 1.10A 5eypB-3gbzA:
undetectable		 5eypB-3gbzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 LEU A 220
ALA A 226
ILE A 100
ALA A  96
ILE A 231
 None
 1.22A 5eypB-3hhsA:
undetectable		 5eypB-3hhsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		5 LEU A 106
LEU A 113
LEU A  95
ILE A 293
ALA A 292
 None
 0.76A 5eypB-3jv9A:
undetectable		 5eypB-3jv9A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.81A 5eypB-3k1jA:
undetectable		 5eypB-3k1jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		5 LEU A  63
ASN A  81
THR A   5
ALA A   7
ILE A  85
 None
 1.26A 5eypB-3k53A:
2.7		 5eypB-3k53A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		5 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.19A 5eypB-3klbA:
4.3		 5eypB-3klbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvs C-PHYCOCYANIN BETA
CHAIN

(Galdieria
sulphuraria) 		PF00502
(Phycobilisome) 		5 LEU B 105
ALA B 167
ILE B  97
ALA B  96
ILE B  44
 None
 1.01A 5eypB-3kvsB:
undetectable		 5eypB-3kvsB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 LEU A 200
ALA A 202
ILE A 195
ALA A 185
ILE A 243
 None
 1.05A 5eypB-3l7gA:
undetectable		 5eypB-3l7gA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwg MICROCOMPARTMENTS
PROTEIN

(Desulfitobacterium
hafniense) 		PF00936
(BMC) 		5 LEU A 122
ALA A 115
ILE A  84
ALA A  83
ILE A   4
 None
 1.25A 5eypB-3nwgA:
undetectable		 5eypB-3nwgA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		5 LEU A 101
ALA A 117
ILE A  69
ALA A  41
ILE A  71
 None
 1.30A 5eypB-3qbdA:
3.5		 5eypB-3qbdA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		5 ALA A  68
THR A 184
ALA A 133
ALA A  52
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
 1.29A 5eypB-3r3sA:
6.7		 5eypB-3r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		5 ALA A  68
THR A 184
ALA A 133
ILE A 131
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
 1.13A 5eypB-3r3sA:
6.7		 5eypB-3r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 525
LEU A 498
LEU A 503
THR A 459
ILE A 486
 None
 1.05A 5eypB-3rg1A:
undetectable		 5eypB-3rg1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.80A 5eypB-3twdA:
undetectable		 5eypB-3twdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 214
ALA A 233
ILE A 245
ALA A 244
ILE A 575
 None
 0.96A 5eypB-3u1kA:
undetectable		 5eypB-3u1kA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		5 LEU A  75
ALA A  77
ILE A 427
ALA A 433
ILE A 424
 None
 1.20A 5eypB-3ubrA:
undetectable		 5eypB-3ubrA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		5 CYH A 486
LEU A 412
ALA A 490
LEU A 254
ILE A 396
 None
 1.12A 5eypB-3unvA:
undetectable		 5eypB-3unvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 CYH A  28
ASN A  18
ALA A  16
ILE A  49
ILE A   6
 None
 1.27A 5eypB-3vr5A:
2.3		 5eypB-3vr5A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 475
LEU A 395
LEU A 421
ASN A 400
ILE A 409
 None
 1.18A 5eypB-3wpeA:
undetectable		 5eypB-3wpeA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 284
LEU A 236
LEU A 262
ASN A 241
ILE A 246
 None
 1.14A 5eypB-3zyoA:
undetectable		 5eypB-3zyoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4an7 TRYPSIN INHIBITOR

(Tamarindus
indica) 		PF00197
(Kunitz_legume) 		5 LEU B  76
ASN B  77
ILE B  67
ALA B  65
ILE B  70
 None
 1.21A 5eypB-4an7B:
undetectable		 5eypB-4an7B:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cge RESUSCITATION-PROMOT
ING FACTOR RPFE

(Mycobacterium
tuberculosis) 		PF06737
(Transglycosylas) 		5 LEU A 125
ALA A 105
ASN A 100
ALA A 153
ILE A 162
 None
 1.06A 5eypB-4cgeA:
undetectable		 5eypB-4cgeA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		5 CYH A  34
ASN A 100
ILE A  51
ALA A  97
ILE A  71
 None
 1.00A 5eypB-4d7pA:
undetectable		 5eypB-4d7pA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A 140
ALA A 308
LEU A 297
ILE A 100
ALA A  99
 None
 0.78A 5eypB-4e51A:
undetectable		 5eypB-4e51A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A 103
ALA A  83
ILE A  78
LYS A  58
ALA A  60
 None
 0.93A 5eypB-4fhoA:
undetectable		 5eypB-4fhoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A  83
ALA A 103
ASN A 134
ILE A  94
ALA A  86
 None
 1.30A 5eypB-4hrlA:
undetectable		 5eypB-4hrlA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iau BETA-GAMMA-CRYSTALLI
N

(Geodia cydonium) 		PF00030
(Crystall) 		5 LEU A 101
LEU A 156
ALA A 116
ILE A 118
ALA A  86
 None
 0.99A 5eypB-4iauA:
undetectable		 5eypB-4iauA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb8 DARPIN C7_16

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU P  84
ALA P 104
ASN P 135
ILE P  95
ALA P  87
 None
 1.30A 5eypB-4jb8P:
undetectable		 5eypB-4jb8P:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 LEU A 184
LEU A 153
ALA A 192
ILE A 199
ALA A  89
 None
 1.18A 5eypB-4kpgA:
3.0		 5eypB-4kpgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 LEU A 184
LEU A 153
ALA A 192
ILE A 199
ALA A  89
 None
 1.21A 5eypB-4m1zA:
2.7		 5eypB-4m1zA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		5 ALA A  16
ALA A  11
LYS A  34
ALA A  29
ILE A  86
 None
 1.22A 5eypB-4m8sA:
6.4		 5eypB-4m8sA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6s C-PHYCOCYANIN BETA
SUBUNIT

(Thermosynechococcus
vulcanus) 		PF00502
(Phycobilisome) 		5 LEU B 107
ALA B 169
ILE B  99
ALA B  98
ILE B  44
 None
 1.00A 5eypB-4n6sB:
undetectable		 5eypB-4n6sB:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhw GLUTATHIONE
S-TRANSFERASE

(Sinorhizobium
meliloti) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 LEU A  81
ASN A  80
ALA A 170
ALA A 109
ILE A 102
 None
 1.23A 5eypB-4nhwA:
undetectable		 5eypB-4nhwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 ALA A   4
ILE A  49
LYS A 222
ALA A 220
ILE A 183
 None
 0.91A 5eypB-4pqiA:
undetectable		 5eypB-4pqiA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpg PROTON:OLIGOPEPTIDE
SYMPORTER POT FAMILY

(Shewanella
oneidensis) 		PF00854
(PTR2) 		5 LEU A 160
LEU A  34
ALA A 181
ASN A 169
ALA A 323
 None
 0.92A 5eypB-4tpgA:
undetectable		 5eypB-4tpgA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		5 LEU A  95
ALA A 184
ILE A 182
ALA A  17
ILE A 210
 None
 0.89A 5eypB-4twiA:
3.8		 5eypB-4twiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 ALA A  75
LEU A  52
ILE A  40
ALA A  60
ILE A  26
 None
 0.91A 5eypB-4yeiA:
undetectable		 5eypB-4yeiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		5 ALA A  99
LEU A  58
ASN A  56
ALA A  50
ILE A 354
 None
 1.05A 5eypB-4yhgA:
undetectable		 5eypB-4yhgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.83A 5eypB-4zpxA:
undetectable		 5eypB-4zpxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 LEU A 200
ALA A 202
ILE A 195
ALA A 185
ILE A 243
 None
 1.06A 5eypB-4zwoA:
undetectable		 5eypB-4zwoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyl FIMBRIAL SUBUNIT
CUPB6

(Pseudomonas
aeruginosa) 		PF00419
(Fimbrial) 		5 LEU A  42
LEU A 153
ASN A 152
ALA A 191
ILE A  86
 None
 1.26A 5eypB-5cylA:
undetectable		 5eypB-5cylA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 373
LEU A 407
ALA A 441
ALA A 437
ILE A 446
 None
 1.13A 5eypB-5dgtA:
2.4		 5eypB-5dgtA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1v POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		no annotation 5 LEU B  62
ALA B  94
ILE B  92
ALA B 114
ILE B  80
 None
 0.96A 5eypB-5e1vB:
undetectable		 5eypB-5e1vB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey2 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus cereus) 		PF06018
(CodY)
PF08222
(HTH_CodY) 		5 ASN A 219
ALA A 186
ILE A 206
ALA A 207
ILE A 190
 None
 0.98A 5eypB-5ey2A:
undetectable		 5eypB-5ey2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 5 LEU A  64
LEU A  45
ILE A 105
ALA A 106
ILE A 101
 None
 1.05A 5eypB-5ig9A:
undetectable		 5eypB-5ig9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA

(Escherichia
coli) 		PF01335
(DED)
PF13416
(SBP_bac_8) 		5 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
 None
 1.00A 5eypB-5jqeA:
undetectable		 5eypB-5jqeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.30A 5eypB-5le9A:
undetectable		 5eypB-5le9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A 206
ALA A 226
ASN A 257
ILE A 217
ALA A 209
 None
 1.30A 5eypB-5le9A:
undetectable		 5eypB-5le9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  84
ALA A 104
ASN A 135
ILE A  95
ALA A  87
 None
 1.29A 5eypB-5lebA:
undetectable		 5eypB-5lebA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 236
ALA A 256
ASN A 287
ILE A 247
ALA A 239
 None
 1.28A 5eypB-5lebA:
undetectable		 5eypB-5lebA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 388
ALA A 408
ASN A 439
ILE A 399
ALA A 391
 None
 1.29A 5eypB-5lebA:
undetectable		 5eypB-5lebA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 LEU A 266
ALA A 234
ILE A 236
ALA A 226
ILE A 271
 None
 1.03A 5eypB-5lm7A:
undetectable		 5eypB-5lm7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mak R7

(synthetic
construct) 		no annotation 5 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.30A 5eypB-5makA:
undetectable		 5eypB-5makA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  64
LEU A  53
LEU A  20
ALA A  11
ALA A  69
 None
 1.22A 5eypB-5mdhA:
undetectable		 5eypB-5mdhA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 LEU B 165
LEU B 341
ALA B 244
ILE B 246
ILE B   6
 None
 1.19A 5eypB-5my0B:
undetectable		 5eypB-5my0B:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 LEU A 838
ALA A 829
ILE A 845
ALA A 846
ILE A 774
 None
 0.92A 5eypB-5nz7A:
1.8		 5eypB-5nz7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2s DARPIN K27

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU B  94
ALA B 114
ASN B 145
ILE B 105
ALA B  97
 None
 1.28A 5eypB-5o2sB:
undetectable		 5eypB-5o2sB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		5 ALA A 185
THR A 174
ALA A 176
ILE A 290
ALA A 293
 None
 0.99A 5eypB-5xfaA:
undetectable		 5eypB-5xfaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 5 LEU A 283
LEU A 338
ILE A 272
ALA A 312
ILE A 212
 None
 1.22A 5eypB-5y0mA:
undetectable		 5eypB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 5 LEU A  47
ALA A  58
LEU A  56
ILE A 287
ALA A 285
 None
 1.25A 5eypB-5yy8A:
undetectable		 5eypB-5yy8A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU A 139
LEU A 122
ASN A 124
ILE A 132
LYS A 127
 None
 1.12A 5eypB-6apxA:
undetectable		 5eypB-6apxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU A 139
LEU A 122
THR A 245
ILE A 132
LYS A 127
 None
 1.12A 5eypB-6apxA:
undetectable		 5eypB-6apxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 5 CYH A 498
LEU A 501
LEU A 415
ILE A 469
ALA A 470
 None
 1.02A 5eypB-6bfnA:
undetectable		 5eypB-6bfnA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE

(Chaetomium
thermophilum) 		no annotation 5 ALA A 167
THR A 139
ALA A 141
ILE A 143
ILE A 130
 None
 0.87A 5eypB-6dg4A:
undetectable		 5eypB-6dg4A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5e DD_D12_10_47

(synthetic
construct) 		no annotation 5 LEU A  84
ALA A 104
ASN A 135
ILE A  95
ALA A  87
 None
 1.30A 5eypB-6f5eA:
undetectable		 5eypB-6f5eA:
12.44