SIMILAR PATTERNS OF AMINO ACIDS FOR 5EYP_B_LOCB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at0 17-HEDGEHOG

(Drosophila
melanogaster) 		PF01079
(Hint) 		3 SER A 399
ALA A 397
VAL A 396
 None
 0.57A 5eypA-1at0A:
undetectable		 5eypA-1at0A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		3 SER M  36
ALA M  34
VAL M  33
 GOL  M 936 ( 4.5A)
None
None
 0.53A 5eypA-1dwaM:
undetectable		 5eypA-1dwaM:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1etz FAB NC10.14 - HEAVY
CHAIN

(Mus musculus) 		no annotation 3 SER H 216
ALA H 211
VAL H 210
 None
 0.55A 5eypA-1etzH:
undetectable		 5eypA-1etzH:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		3 SER A 368
ALA A 366
VAL A 365
 None
 0.59A 5eypA-1f3lA:
0.4		 5eypA-1f3lA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibg IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.51A 5eypA-1ibgH:
undetectable		 5eypA-1ibgH:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igj IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 216
ALA B 211
VAL B 210
 None
 0.57A 5eypA-1igjB:
undetectable		 5eypA-1igjB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igt IGG2A INTACT
ANTIBODY - MAB231

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 216
ALA B 211
VAL B 210
 None
 0.54A 5eypA-1igtB:
undetectable		 5eypA-1igtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhk IG GAMMA-1-CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.58A 5eypA-1jhkH:
undetectable		 5eypA-1jhkH:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 SER B  64
ALA B  40
VAL B  39
 None
 0.57A 5eypA-1jtdB:
undetectable		 5eypA-1jtdB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mex FAB 29G12 HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.58A 5eypA-1mexH:
undetectable		 5eypA-1mexH:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 SER A 194
ALA A 174
VAL A 173
 None
 0.57A 5eypA-1nnwA:
undetectable		 5eypA-1nnwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		3 SER A 130
ALA A 174
VAL A 185
 None
 0.54A 5eypA-1p3cA:
undetectable		 5eypA-1p3cA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER A 226
ALA A 228
VAL A 229
 None
 0.43A 5eypA-1spjA:
undetectable		 5eypA-1spjA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		3 SER A 239
ALA A 174
VAL A 173
 None
 0.56A 5eypA-1t8hA:
undetectable		 5eypA-1t8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 SER A 106
ALA A 104
VAL A 103
 None
 0.53A 5eypA-1wdtA:
2.7		 5eypA-1wdtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xov PLY PROTEIN

(Listeria virus
PSA) 		PF01520
(Amidase_3) 		3 SER A 185
ALA A 187
VAL A 188
 None
 0.39A 5eypA-1xovA:
3.8		 5eypA-1xovA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y30 HYPOTHETICAL PROTEIN
RV1155

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		3 SER A 137
ALA A  82
VAL A  81
 None
 0.44A 5eypA-1y30A:
undetectable		 5eypA-1y30A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqq XANTHOSINE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		3 SER A  50
ALA A  48
VAL A  47
 None
 0.55A 5eypA-1yqqA:
3.4		 5eypA-1yqqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		3 SER A  86
ALA A 160
VAL A 159
 None
 0.53A 5eypA-2freA:
undetectable		 5eypA-2freA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER D 213
ALA D 208
VAL D 207
 None
 0.57A 5eypA-2hmiD:
undetectable		 5eypA-2hmiD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 3 SER B 457
ALA B 446
VAL B 445
 None
 0.54A 5eypA-2j04B:
undetectable		 5eypA-2j04B:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfi 30S RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00575
(S1) 		3 SER A  22
ALA A  71
VAL A  70
 None
 0.51A 5eypA-2mfiA:
undetectable		 5eypA-2mfiA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok0 FAB ED10 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.58A 5eypA-2ok0H:
undetectable		 5eypA-2ok0H:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		3 SER A 105
ALA A  72
VAL A  71
 None
 0.53A 5eypA-2qz8A:
undetectable		 5eypA-2qz8A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		3 SER A  43
ALA A 143
VAL A 142
 SER  A  43 ( 0.0A)
ALA  A 143 ( 0.0A)
VAL  A 142 ( 0.5A)
 0.56A 5eypA-2v9uA:
undetectable		 5eypA-2v9uA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy A13-D6.3 MONOCLONAL
ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER G 203
ALA G 198
VAL G 197
 None
 0.53A 5eypA-2xqyG:
undetectable		 5eypA-2xqyG:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		3 SER A 224
ALA A 226
VAL A 227
 None
 0.55A 5eypA-2yg1A:
undetectable		 5eypA-2yg1A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk1 FAB FRAGMENT, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  28
ALA H  94
VAL H  93
 None
None
NCT  H 300 (-4.3A)
 0.53A 5eypA-2yk1H:
undetectable		 5eypA-2yk1H:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 SER A  55
ALA A  72
VAL A  73
 None
 0.58A 5eypA-2z1uA:
undetectable		 5eypA-2z1uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 208
ALA B 203
VAL B 202
 None
 0.58A 5eypA-2z4qB:
undetectable		 5eypA-2z4qB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.57A 5eypA-2zpkH:
undetectable		 5eypA-2zpkH:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		3 SER A 430
ALA A 428
VAL A 427
 None
 0.58A 5eypA-3b8kA:
undetectable		 5eypA-3b8kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		3 SER A  89
ALA A 111
VAL A 110
 MLA  A4892 (-3.2A)
None
None
 0.46A 5eypA-3bf8A:
1.7		 5eypA-3bf8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		3 SER A 102
ALA A 129
VAL A 128
 SO4  A 255 (-2.2A)
None
None
 0.42A 5eypA-3ds8A:
5.0		 5eypA-3ds8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 SER A 183
ALA A 185
VAL A 186
 None
 0.57A 5eypA-3gd5A:
undetectable		 5eypA-3gd5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		3 SER A 245
ALA A 241
VAL A 240
 None
 0.44A 5eypA-3hheA:
undetectable		 5eypA-3hheA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb3 PROTEIN PHOSPHATASE
2C 16

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		3 SER B 399
ALA B 329
VAL B 330
 None
 0.56A 5eypA-3kb3B:
undetectable		 5eypA-3kb3B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 3 SER A 244
ALA A 169
VAL A 170
 None
 0.43A 5eypA-3kptA:
undetectable		 5eypA-3kptA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE

(Mesorhizobium
loti) 		PF12697
(Abhydrolase_6) 		3 SER A 106
ALA A 128
VAL A 127
 CL  A 279 (-2.8A)
None
None
 0.59A 5eypA-3kxpA:
4.1		 5eypA-3kxpA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mck C705 MONOCLONAL
HEAVY CHAIN

(Mus musculus) 		no annotation 3 SER H 213
ALA H 208
VAL H 207
 None
 0.58A 5eypA-3mckH:
undetectable		 5eypA-3mckH:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp2 NON-STRUCTURAL
PROTEIN 3

(Alphacoronavirus
1) 		PF08715
(Viral_protease) 		3 SER A 148
ALA A 115
VAL A 116
 None
 0.54A 5eypA-3mp2A:
undetectable		 5eypA-3mp2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 SER A 717
ALA A 719
VAL A 720
 None
 0.49A 5eypA-3n6rA:
undetectable		 5eypA-3n6rA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER F 212
ALA F 207
VAL F 206
 None
 0.52A 5eypA-3riaF:
undetectable		 5eypA-3riaF:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkd CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		3 SER A 582
ALA A 580
VAL A 579
 None
 0.58A 5eypA-3rkdA:
undetectable		 5eypA-3rkdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgi DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB) 		3 SER A 130
ALA A 128
VAL A 127
 None
AMP  A 616 ( 3.8A)
None
 0.47A 5eypA-3sgiA:
undetectable		 5eypA-3sgiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7y YOP PROTEINS
TRANSLOCATION
PROTEIN U

(Chlamydia
trachomatis) 		PF01312
(Bac_export_2) 		3 SER A 257
ALA A 269
VAL A 268
 None
 0.55A 5eypA-3t7yA:
undetectable		 5eypA-3t7yA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		3 SER A 233
ALA A 226
VAL A 227
 None
 0.55A 5eypA-3twkA:
undetectable		 5eypA-3twkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.57A 5eypA-3v0wH:
undetectable		 5eypA-3v0wH:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		3 SER A 173
ALA A 175
VAL A 176
 None
 0.50A 5eypA-3vvlA:
3.3		 5eypA-3vvlA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 SER A 498
ALA A 488
VAL A 487
 None
 0.57A 5eypA-3w1gA:
undetectable		 5eypA-3w1gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfh MAB FAB H FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER A 207
ALA A 202
VAL A 201
 None
 0.57A 5eypA-3wfhA:
undetectable		 5eypA-3wfhA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		3 SER A  15
ALA A  13
VAL A  12
 GOL  A 902 ( 4.6A)
None
None
 0.57A 5eypA-3zjkA:
undetectable		 5eypA-3zjkA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 3 SER A 391
ALA A 355
VAL A 354
 None
 0.55A 5eypA-4a7kA:
undetectable		 5eypA-4a7kA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8j ELONGATOR COMPLEX
PROTEIN 5

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1) 		3 SER B 108
ALA B 133
VAL B 132
 None
 0.48A 5eypA-4a8jB:
undetectable		 5eypA-4a8jB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.57A 5eypA-4ag4H:
undetectable		 5eypA-4ag4H:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz2 FAB 2D73 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 211
ALA H 206
VAL H 205
 None
 0.58A 5eypA-4bz2H:
undetectable		 5eypA-4bz2H:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chu HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ISCR

(Escherichia
coli) 		PF02082
(Rrf2) 		3 SER A  73
ALA A  75
VAL A  76
 None
 0.44A 5eypA-4chuA:
undetectable		 5eypA-4chuA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dw2 FAB FRAGMENT OF
PRO-UPA ANTIBODY
MAB-112

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 197
ALA H 192
VAL H 191
 None
 0.56A 5eypA-4dw2H:
undetectable		 5eypA-4dw2H:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1) 		3 SER B 108
ALA B 133
VAL B 132
 None
 0.52A 5eypA-4ejsB:
undetectable		 5eypA-4ejsB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffz DENV1-E111 FAB
FRAGMENT (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.56A 5eypA-4ffzH:
undetectable		 5eypA-4ffzH:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq9 CHIKUNGUNYA VIRUS
NEUTRALIZING
ANTIBODY 9.8B FAB
FRAGMENT HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 208
ALA H 203
VAL H 202
 None
 0.56A 5eypA-4gq9H:
undetectable		 5eypA-4gq9H:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		3 SER A 148
ALA A 145
VAL A 144
 None
 0.42A 5eypA-4guzA:
undetectable		 5eypA-4guzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hf0 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ISCR

(Escherichia
coli) 		PF02082
(Rrf2) 		3 SER A  73
ALA A  75
VAL A  76
 None
 0.43A 5eypA-4hf0A:
undetectable		 5eypA-4hf0A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		3 SER A  76
ALA A  78
VAL A  79
 None
 0.56A 5eypA-4ho4A:
undetectable		 5eypA-4ho4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.55A 5eypA-4k3eH:
undetectable		 5eypA-4k3eH:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 3 SER B  44
ALA B  22
VAL B  21
 SO4  B 301 (-3.2A)
None
None
 0.45A 5eypA-4mkiB:
undetectable		 5eypA-4mkiB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		3 SER A  68
ALA A  32
VAL A  31
 None
 0.49A 5eypA-4o8mA:
undetectable		 5eypA-4o8mA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		3 SER A  67
ALA A  31
VAL A  30
 None
 0.52A 5eypA-4ovtA:
undetectable		 5eypA-4ovtA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		3 SER A 854
ALA A 852
VAL A 851
 None
 0.57A 5eypA-4q2cA:
undetectable		 5eypA-4q2cA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q80 SERINE PROTEASE 57

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER A  26
ALA A 117
VAL A 118
 None
 0.56A 5eypA-4q80A:
undetectable		 5eypA-4q80A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 202
ALA H 197
VAL H 196
 None
 0.57A 5eypA-4qexH:
undetectable		 5eypA-4qexH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 SER A 232
ALA A 234
VAL A 235
 None
 0.59A 5eypA-4rvsA:
3.1		 5eypA-4rvsA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4web MOUSE FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 208
ALA H 203
VAL H 202
 None
 0.58A 5eypA-4webH:
undetectable		 5eypA-4webH:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		3 SER A 308
ALA A 310
VAL A 311
 None
 0.54A 5eypA-4wy9A:
undetectable		 5eypA-4wy9A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl1 DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		3 SER B 148
ALA B 150
VAL B 151
 None
 0.37A 5eypA-4xl1B:
undetectable		 5eypA-4xl1B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xlw DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		3 SER B 148
ALA B 150
VAL B 151
 None
 0.38A 5eypA-4xlwB:
undetectable		 5eypA-4xlwB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		3 SER A 359
ALA A 402
VAL A 401
 None
 0.52A 5eypA-4y61A:
undetectable		 5eypA-4y61A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 SLIT AND NTRK-LIKE
PROTEIN 2

(Mus musculus) 		PF13855
(LRR_8) 		3 SER B  86
ALA B  88
VAL B  89
 None
 0.56A 5eypA-4y61B:
undetectable		 5eypA-4y61B:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		no annotation 3 SER B 349
ALA B 392
VAL B 391
 None
 0.58A 5eypA-4yfgB:
undetectable		 5eypA-4yfgB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 SER A 665
ALA A 717
VAL A 716
 None
 0.45A 5eypA-4ypjA:
2.9		 5eypA-4ypjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0b ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 211
ALA H 206
VAL H 205
 None
 0.56A 5eypA-4z0bH:
undetectable		 5eypA-4z0bH:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb FAB 83-7 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER A 208
ALA A 203
VAL A 202
 None
 0.57A 5eypA-4zxbA:
undetectable		 5eypA-4zxbA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		3 SER A 750
ALA A 752
VAL A 753
 None
 0.56A 5eypA-5a42A:
undetectable		 5eypA-5a42A:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoq PREPROPTTH

(Bombyx mori) 		no annotation 3 SER L  84
ALA L  82
VAL L  81
 None
 0.57A 5eypA-5aoqL:
undetectable		 5eypA-5aoqL:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwj SENSORY TRANSDUCTION
HISTIDINE KINASE,
PUTATIVE

(Borreliella
burgdorferi) 		PF00497
(SBP_bac_3) 		3 SER A 214
ALA A 212
VAL A 211
 None
 0.55A 5eypA-5bwjA:
undetectable		 5eypA-5bwjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqx DESMOGLEIN-3

(Homo sapiens) 		PF00028
(Cadherin) 		3 SER A 297
ALA A 299
VAL A 300
 None
 0.53A 5eypA-5eqxA:
undetectable		 5eypA-5eqxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 SER E  35
ALA E  37
VAL E  38
 None
 0.57A 5eypA-5fmgE:
undetectable		 5eypA-5fmgE:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1s 50S RIBOSOMAL
PROTEIN L13,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00572
(Ribosomal_L13) 		3 SER L 164
ALA L 162
VAL L 161
 U  A1168 ( 3.4A)
None
None
 0.51A 5eypA-5h1sL:
undetectable		 5eypA-5h1sL:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdb MONOCLONAL ANTIBODY
10E5 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER E 209
ALA E 204
VAL E 203
 None
 0.58A 5eypA-5hdbE:
undetectable		 5eypA-5hdbE:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 SER A 533
ALA A 531
VAL A 530
 None
 0.58A 5eypA-5i2tA:
undetectable		 5eypA-5i2tA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i73 8B6 ANTIBODY, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 228
ALA B 223
VAL B 222
 None
 0.50A 5eypA-5i73B:
undetectable		 5eypA-5i73B:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		3 SER A 169
ALA A 171
VAL A 172
 None
None
TRH  A 500 (-3.9A)
 0.57A 5eypA-5ifyA:
undetectable		 5eypA-5ifyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		3 SER A  25
ALA A 298
VAL A 297
 None
 0.53A 5eypA-5l8sA:
3.4		 5eypA-5l8sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m63 L CHAIN OF FAB
NVS-1-19-5

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER L  34
ALA L  36
VAL L  37
 None
 0.49A 5eypA-5m63L:
undetectable		 5eypA-5m63L:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mi0 MONOCLONAL ANTIBODY
9AD4

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 212
ALA B 207
VAL B 206
 None
 0.55A 5eypA-5mi0B:
undetectable		 5eypA-5mi0B:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhy ZV67 FAB CHAIN 2

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.55A 5eypA-5uhyH:
undetectable		 5eypA-5uhyH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 3 SER A  21
ALA A  19
VAL A  18
 None
 0.52A 5eypA-5xgzA:
undetectable		 5eypA-5xgzA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq7 POM6 FAB HEAVY CHAIN

(Mus musculus) 		no annotation 3 SER H 204
ALA H 199
VAL H 198
 None
 0.57A 5eypA-6aq7H:
undetectable		 5eypA-6aq7H:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 3 SER A 389
ALA A 427
VAL A 426
 None
 0.58A 5eypA-6eo5A:
undetectable		 5eypA-6eo5A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 3 SER A 801
ALA A 813
VAL A 812
 None
 0.45A 5eypA-6fq3A:
undetectable		 5eypA-6fq3A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 128
LEU A 319
THR A 301
ALA A 287
ILE A 274
 None
 1.17A 5eypB-1bkhA:
3.6		 5eypB-1bkhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpc C-PHYCOCYANIN (BETA
SUBUNIT)

(Microchaete
diplosiphon) 		PF00502
(Phycobilisome) 		5 LEU B 107
ALA B 169
ILE B  99
ALA B  98
ILE B  44
 None
 0.98A 5eypB-1cpcB:
undetectable		 5eypB-1cpcB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 LEU A 259
ASN A 209
ALA A 207
ILE A 203
ILE A 167
 None
 1.25A 5eypB-1dysA:
undetectable		 5eypB-1dysA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A 103
ALA A  83
ILE A  78
LYS A  58
ALA A  60
 None
 0.77A 5eypB-1h6uA:
undetectable		 5eypB-1h6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF00483
(NTP_transferase) 		5 LEU A  76
LEU A  68
ILE A  10
ALA A 106
ILE A  43
 None
None
None
CDC  A1991 (-3.6A)
None
 1.01A 5eypB-1jylA:
undetectable		 5eypB-1jylA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4n PROTEIN EC4020

(Escherichia
coli) 		PF06185
(YecM) 		5 ALA A  93
LEU A  28
ILE A 120
ALA A  44
ILE A 175
 None
 1.28A 5eypB-1k4nA:
undetectable		 5eypB-1k4nA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 LEU A 286
ALA A 259
ASN A 254
ALA A 234
ILE A 231
 None
 0.83A 5eypB-1l8wA:
undetectable		 5eypB-1l8wA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		5 LEU E 951
ALA E1002
LEU E 915
ILE E 990
ALA E 988
 None
 1.02A 5eypB-1o7dE:
undetectable		 5eypB-1o7dE:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 CYH A 929
LEU A 926
ALA A 889
LEU A 885
ILE A 806
 None
 1.05A 5eypB-1sojA:
undetectable		 5eypB-1sojA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		5 ALA A 149
LEU A 147
ALA A 107
ILE A  69
ALA A  91
 None
 0.84A 5eypB-1ur4A:
3.0		 5eypB-1ur4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ALA A 128
ALA A  78
ILE A  75
LYS A  53
ALA A  57
 None
 1.01A 5eypB-1vdkA:
undetectable		 5eypB-1vdkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)
PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3)
no annotation 		5 LEU P  18
ALA P  14
THR A 447
ILE P  37
ALA P  36
 None
 1.00A 5eypB-2btvP:
undetectable		 5eypB-2btvP:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 5 LEU P  18
ALA P  14
ASN P  28
ILE P  37
ALA P  36
 None
 1.21A 5eypB-2btvP:
undetectable		 5eypB-2btvP:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.26A 5eypB-2ffhA:
3.5		 5eypB-2ffhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24

(Trypanosoma
brucei) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 LEU A 150
LEU A 152
ASN A 177
ALA A 172
ILE A 169
 None
 1.20A 5eypB-2lvvA:
undetectable		 5eypB-2lvvA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.30A 5eypB-2ng1A:
undetectable		 5eypB-2ng1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 LEU A 288
ALA A 189
LEU A 191
THR A 196
ILE A 232
 None
None
None
NAP  A 402 (-3.3A)
NAP  A 402 ( 4.8A)
 1.14A 5eypB-2o7pA:
undetectable		 5eypB-2o7pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 THR A 329
ALA A 303
LYS A 304
ALA A 254
ILE A 280
 None
 1.24A 5eypB-2odlA:
undetectable		 5eypB-2odlA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.85A 5eypB-2oi6A:
undetectable		 5eypB-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		5 LEU A1179
ALA A1113
ALA A1186
ILE A1208
ILE A1135
 None
 1.05A 5eypB-2p3vA:
undetectable		 5eypB-2p3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkq GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
B

(Spinacia
oleracea) 		PF00044
(Gp_dh_N)
PF02672
(CP12)
PF02800
(Gp_dh_C) 		5 LEU O 324
ALA O 122
ILE O 118
ALA O 120
ILE O 125
 None
None
None
NDP  O 363 ( 3.7A)
None
 1.25A 5eypB-2pkqO:
3.9		 5eypB-2pkqO:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 128
ALA A 387
LEU A 384
ALA A 353
ILE A 344
 None
 1.28A 5eypB-2ptzA:
undetectable		 5eypB-2ptzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 208
LEU A 151
THR A 127
ALA A 224
ILE A 185
 None
 0.79A 5eypB-2qo3A:
undetectable		 5eypB-2qo3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT

(Bacillus
subtilis) 		PF02302
(PTS_IIB) 		5 LEU A  97
ALA A   1
ILE A  60
LYS A  76
ALA A  96
 None
 1.19A 5eypB-2r48A:
2.4		 5eypB-2r48A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 167
LEU A  65
ALA A 123
ILE A 125
ILE A  76
 None
 0.84A 5eypB-2v7bA:
undetectable		 5eypB-2v7bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wiz ARCHAEAL HJC

(Archaeoglobus
fulgidus) 		PF01870
(Hjc) 		5 ALA A  23
LEU A  48
ALA A 124
ILE A 120
ALA A  19
 None
 1.16A 5eypB-2wizA:
undetectable		 5eypB-2wizA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]

(Methanocaldococcus
jannaschii) 		PF13847
(Methyltransf_31) 		5 THR A 131
ALA A 129
ILE A 127
ALA A 181
ILE A 106
 None
 0.78A 5eypB-2yxdA:
3.1		 5eypB-2yxdA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		5 LEU A 419
LEU A 482
ASN A 466
ALA A 496
ILE A 617
 None
 1.18A 5eypB-2zj8A:
undetectable		 5eypB-2zj8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aty PROSTAGLANDIN F2A
SYNTHASE

(Trypanosoma
cruzi) 		PF00724
(Oxidored_FMN) 		5 LEU A  99
LEU A  11
ILE A  23
LYS A 310
ALA A 332
 None
 1.00A 5eypB-3atyA:
4.3		 5eypB-3atyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwq CAPSID PROTEIN VP1

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 CYH A  49
LEU A  51
THR A 218
ILE A  93
ALA A  91
 None
 1.11A 5eypB-3bwqA:
undetectable		 5eypB-3bwqA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 LEU A 374
ASN A 378
ALA A 358
ALA A 333
ILE A 360
 None
 0.99A 5eypB-3bz5A:
undetectable		 5eypB-3bz5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU A   9
ALA A  63
ILE A  65
ALA A  70
ILE A  32
 None
 0.67A 5eypB-3ctzA:
undetectable		 5eypB-3ctzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3k UNCHARACTERIZED
PROTEIN YKR043C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		5 LEU A  97
ALA A 175
ILE A 152
ALA A 151
ILE A 186
 None
 1.27A 5eypB-3f3kA:
undetectable		 5eypB-3f3kA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Rickettsia
prowazekii) 		PF13561
(adh_short_C2) 		5 LEU A 114
LEU A  70
ILE A  11
ALA A  14
ILE A  34
 None
 1.26A 5eypB-3f9iA:
7.3		 5eypB-3f9iA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU

(Yersinia pestis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.92A 5eypB-3fwwA:
undetectable		 5eypB-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		5 LEU A 275
LEU A 282
LEU A 266
THR A 214
ALA A 204
 None
 1.10A 5eypB-3gbzA:
undetectable		 5eypB-3gbzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 LEU A 220
ALA A 226
ILE A 100
ALA A  96
ILE A 231
 None
 1.22A 5eypB-3hhsA:
undetectable		 5eypB-3hhsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		5 LEU A 106
LEU A 113
LEU A  95
ILE A 293
ALA A 292
 None
 0.76A 5eypB-3jv9A:
undetectable		 5eypB-3jv9A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.81A 5eypB-3k1jA:
undetectable		 5eypB-3k1jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		5 LEU A  63
ASN A  81
THR A   5
ALA A   7
ILE A  85
 None
 1.26A 5eypB-3k53A:
2.7		 5eypB-3k53A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		5 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.19A 5eypB-3klbA:
4.3		 5eypB-3klbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvs C-PHYCOCYANIN BETA
CHAIN

(Galdieria
sulphuraria) 		PF00502
(Phycobilisome) 		5 LEU B 105
ALA B 167
ILE B  97
ALA B  96
ILE B  44
 None
 1.01A 5eypB-3kvsB:
undetectable		 5eypB-3kvsB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 LEU A 200
ALA A 202
ILE A 195
ALA A 185
ILE A 243
 None
 1.05A 5eypB-3l7gA:
undetectable		 5eypB-3l7gA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwg MICROCOMPARTMENTS
PROTEIN

(Desulfitobacterium
hafniense) 		PF00936
(BMC) 		5 LEU A 122
ALA A 115
ILE A  84
ALA A  83
ILE A   4
 None
 1.25A 5eypB-3nwgA:
undetectable		 5eypB-3nwgA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		5 LEU A 101
ALA A 117
ILE A  69
ALA A  41
ILE A  71
 None
 1.30A 5eypB-3qbdA:
3.5		 5eypB-3qbdA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		5 ALA A  68
THR A 184
ALA A 133
ALA A  52
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
 1.29A 5eypB-3r3sA:
6.7		 5eypB-3r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		5 ALA A  68
THR A 184
ALA A 133
ILE A 131
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
 1.13A 5eypB-3r3sA:
6.7		 5eypB-3r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 525
LEU A 498
LEU A 503
THR A 459
ILE A 486
 None
 1.05A 5eypB-3rg1A:
undetectable		 5eypB-3rg1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.80A 5eypB-3twdA:
undetectable		 5eypB-3twdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 214
ALA A 233
ILE A 245
ALA A 244
ILE A 575
 None
 0.96A 5eypB-3u1kA:
undetectable		 5eypB-3u1kA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		5 LEU A  75
ALA A  77
ILE A 427
ALA A 433
ILE A 424
 None
 1.20A 5eypB-3ubrA:
undetectable		 5eypB-3ubrA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		5 CYH A 486
LEU A 412
ALA A 490
LEU A 254
ILE A 396
 None
 1.12A 5eypB-3unvA:
undetectable		 5eypB-3unvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 CYH A  28
ASN A  18
ALA A  16
ILE A  49
ILE A   6
 None
 1.27A 5eypB-3vr5A:
2.3		 5eypB-3vr5A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 475
LEU A 395
LEU A 421
ASN A 400
ILE A 409
 None
 1.18A 5eypB-3wpeA:
undetectable		 5eypB-3wpeA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 284
LEU A 236
LEU A 262
ASN A 241
ILE A 246
 None
 1.14A 5eypB-3zyoA:
undetectable		 5eypB-3zyoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4an7 TRYPSIN INHIBITOR

(Tamarindus
indica) 		PF00197
(Kunitz_legume) 		5 LEU B  76
ASN B  77
ILE B  67
ALA B  65
ILE B  70
 None
 1.21A 5eypB-4an7B:
undetectable		 5eypB-4an7B:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cge RESUSCITATION-PROMOT
ING FACTOR RPFE

(Mycobacterium
tuberculosis) 		PF06737
(Transglycosylas) 		5 LEU A 125
ALA A 105
ASN A 100
ALA A 153
ILE A 162
 None
 1.06A 5eypB-4cgeA:
undetectable		 5eypB-4cgeA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		5 CYH A  34
ASN A 100
ILE A  51
ALA A  97
ILE A  71
 None
 1.00A 5eypB-4d7pA:
undetectable		 5eypB-4d7pA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A 140
ALA A 308
LEU A 297
ILE A 100
ALA A  99
 None
 0.78A 5eypB-4e51A:
undetectable		 5eypB-4e51A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A 103
ALA A  83
ILE A  78
LYS A  58
ALA A  60
 None
 0.93A 5eypB-4fhoA:
undetectable		 5eypB-4fhoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A  83
ALA A 103
ASN A 134
ILE A  94
ALA A  86
 None
 1.30A 5eypB-4hrlA:
undetectable		 5eypB-4hrlA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iau BETA-GAMMA-CRYSTALLI
N

(Geodia cydonium) 		PF00030
(Crystall) 		5 LEU A 101
LEU A 156
ALA A 116
ILE A 118
ALA A  86
 None
 0.99A 5eypB-4iauA:
undetectable		 5eypB-4iauA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb8 DARPIN C7_16

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU P  84
ALA P 104
ASN P 135
ILE P  95
ALA P  87
 None
 1.30A 5eypB-4jb8P:
undetectable		 5eypB-4jb8P:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 LEU A 184
LEU A 153
ALA A 192
ILE A 199
ALA A  89
 None
 1.18A 5eypB-4kpgA:
3.0		 5eypB-4kpgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 LEU A 184
LEU A 153
ALA A 192
ILE A 199
ALA A  89
 None
 1.21A 5eypB-4m1zA:
2.7		 5eypB-4m1zA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		5 ALA A  16
ALA A  11
LYS A  34
ALA A  29
ILE A  86
 None
 1.22A 5eypB-4m8sA:
6.4		 5eypB-4m8sA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6s C-PHYCOCYANIN BETA
SUBUNIT

(Thermosynechococcus
vulcanus) 		PF00502
(Phycobilisome) 		5 LEU B 107
ALA B 169
ILE B  99
ALA B  98
ILE B  44
 None
 1.00A 5eypB-4n6sB:
undetectable		 5eypB-4n6sB:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhw GLUTATHIONE
S-TRANSFERASE

(Sinorhizobium
meliloti) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 LEU A  81
ASN A  80
ALA A 170
ALA A 109
ILE A 102
 None
 1.23A 5eypB-4nhwA:
undetectable		 5eypB-4nhwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 ALA A   4
ILE A  49
LYS A 222
ALA A 220
ILE A 183
 None
 0.91A 5eypB-4pqiA:
undetectable		 5eypB-4pqiA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpg PROTON:OLIGOPEPTIDE
SYMPORTER POT FAMILY

(Shewanella
oneidensis) 		PF00854
(PTR2) 		5 LEU A 160
LEU A  34
ALA A 181
ASN A 169
ALA A 323
 None
 0.92A 5eypB-4tpgA:
undetectable		 5eypB-4tpgA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		5 LEU A  95
ALA A 184
ILE A 182
ALA A  17
ILE A 210
 None
 0.89A 5eypB-4twiA:
3.8		 5eypB-4twiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 ALA A  75
LEU A  52
ILE A  40
ALA A  60
ILE A  26
 None
 0.91A 5eypB-4yeiA:
undetectable		 5eypB-4yeiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		5 ALA A  99
LEU A  58
ASN A  56
ALA A  50
ILE A 354
 None
 1.05A 5eypB-4yhgA:
undetectable		 5eypB-4yhgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.83A 5eypB-4zpxA:
undetectable		 5eypB-4zpxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 LEU A 200
ALA A 202
ILE A 195
ALA A 185
ILE A 243
 None
 1.06A 5eypB-4zwoA:
undetectable		 5eypB-4zwoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyl FIMBRIAL SUBUNIT
CUPB6

(Pseudomonas
aeruginosa) 		PF00419
(Fimbrial) 		5 LEU A  42
LEU A 153
ASN A 152
ALA A 191
ILE A  86
 None
 1.26A 5eypB-5cylA:
undetectable		 5eypB-5cylA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 373
LEU A 407
ALA A 441
ALA A 437
ILE A 446
 None
 1.13A 5eypB-5dgtA:
2.4		 5eypB-5dgtA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1v POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		no annotation 5 LEU B  62
ALA B  94
ILE B  92
ALA B 114
ILE B  80
 None
 0.96A 5eypB-5e1vB:
undetectable		 5eypB-5e1vB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey2 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus cereus) 		PF06018
(CodY)
PF08222
(HTH_CodY) 		5 ASN A 219
ALA A 186
ILE A 206
ALA A 207
ILE A 190
 None
 0.98A 5eypB-5ey2A:
undetectable		 5eypB-5ey2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 5 LEU A  64
LEU A  45
ILE A 105
ALA A 106
ILE A 101
 None
 1.05A 5eypB-5ig9A:
undetectable		 5eypB-5ig9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA

(Escherichia
coli) 		PF01335
(DED)
PF13416
(SBP_bac_8) 		5 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
 None
 1.00A 5eypB-5jqeA:
undetectable		 5eypB-5jqeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.30A 5eypB-5le9A:
undetectable		 5eypB-5le9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A 206
ALA A 226
ASN A 257
ILE A 217
ALA A 209
 None
 1.30A 5eypB-5le9A:
undetectable		 5eypB-5le9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  84
ALA A 104
ASN A 135
ILE A  95
ALA A  87
 None
 1.29A 5eypB-5lebA:
undetectable		 5eypB-5lebA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 236
ALA A 256
ASN A 287
ILE A 247
ALA A 239
 None
 1.28A 5eypB-5lebA:
undetectable		 5eypB-5lebA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 388
ALA A 408
ASN A 439
ILE A 399
ALA A 391
 None
 1.29A 5eypB-5lebA:
undetectable		 5eypB-5lebA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 LEU A 266
ALA A 234
ILE A 236
ALA A 226
ILE A 271
 None
 1.03A 5eypB-5lm7A:
undetectable		 5eypB-5lm7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mak R7

(synthetic
construct) 		no annotation 5 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.30A 5eypB-5makA:
undetectable		 5eypB-5makA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  64
LEU A  53
LEU A  20
ALA A  11
ALA A  69
 None
 1.22A 5eypB-5mdhA:
undetectable		 5eypB-5mdhA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 LEU B 165
LEU B 341
ALA B 244
ILE B 246
ILE B   6
 None
 1.19A 5eypB-5my0B:
undetectable		 5eypB-5my0B:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 LEU A 838
ALA A 829
ILE A 845
ALA A 846
ILE A 774
 None
 0.92A 5eypB-5nz7A:
1.8		 5eypB-5nz7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2s DARPIN K27

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU B  94
ALA B 114
ASN B 145
ILE B 105
ALA B  97
 None
 1.28A 5eypB-5o2sB:
undetectable		 5eypB-5o2sB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		5 ALA A 185
THR A 174
ALA A 176
ILE A 290
ALA A 293
 None
 0.99A 5eypB-5xfaA:
undetectable		 5eypB-5xfaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 5 LEU A 283
LEU A 338
ILE A 272
ALA A 312
ILE A 212
 None
 1.22A 5eypB-5y0mA:
undetectable		 5eypB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 5 LEU A  47
ALA A  58
LEU A  56
ILE A 287
ALA A 285
 None
 1.25A 5eypB-5yy8A:
undetectable		 5eypB-5yy8A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU A 139
LEU A 122
ASN A 124
ILE A 132
LYS A 127
 None
 1.12A 5eypB-6apxA:
undetectable		 5eypB-6apxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU A 139
LEU A 122
THR A 245
ILE A 132
LYS A 127
 None
 1.12A 5eypB-6apxA:
undetectable		 5eypB-6apxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 5 CYH A 498
LEU A 501
LEU A 415
ILE A 469
ALA A 470
 None
 1.02A 5eypB-6bfnA:
undetectable		 5eypB-6bfnA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE

(Chaetomium
thermophilum) 		no annotation 5 ALA A 167
THR A 139
ALA A 141
ILE A 143
ILE A 130
 None
 0.87A 5eypB-6dg4A:
undetectable		 5eypB-6dg4A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5e DD_D12_10_47

(synthetic
construct) 		no annotation 5 LEU A  84
ALA A 104
ASN A 135
ILE A  95
ALA A  87
 None
 1.30A 5eypB-6f5eA:
undetectable		 5eypB-6f5eA:
12.44