SIMILAR PATTERNS OF AMINO ACIDS FOR 5EWZ_B_BEZB301_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ajz | DIHYDROPTEROATESYNTHASE (Escherichiacoli) |
PF00809(Pterin_bind) | 3 | MET A 223GLN A 226ARG A 235 | NoneNoneSO4 A 284 (-2.6A) | 1.12A | 5ewzB-1ajzA:undetectable | 5ewzB-1ajzA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eu8 | TREHALOSE/MALTOSEBINDING PROTEIN (Thermococcuslitoralis) |
PF01547(SBP_bac_1) | 3 | MET A 245GLN A 248ARG A 243 | PT A 415 (-3.2A)NoneNone | 1.11A | 5ewzB-1eu8A:undetectable | 5ewzB-1eu8A:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gxn | PECTATE LYASE (Cellvibriojaponicus) |
PF09492(Pec_lyase) | 3 | MET A 330GLN A 548ARG A 329 | None | 0.97A | 5ewzB-1gxnA:6.8 | 5ewzB-1gxnA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h14 | ENDO-1,4-BETA-XYLANASE (Pseudoalteromonashaloplanktis) |
PF01270(Glyco_hydro_8) | 3 | MET A 40GLN A 48ARG A 379 | None | 0.96A | 5ewzB-1h14A:3.9 | 5ewzB-1h14A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hlb | HEMOGLOBIN (DEOXY) (Molpadiaarenicola) |
PF00042(Globin) | 3 | MET A 70GLN A 69ARG A 68 | None | 1.05A | 5ewzB-1hlbA:undetectable | 5ewzB-1hlbA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ki9 | ADENYLATE KINASE (Methanothermococcusthermolithotrophicus) |
PF13207(AAA_17) | 3 | MET A 59GLN A 58ARG A 60 | None | 1.02A | 5ewzB-1ki9A:undetectable | 5ewzB-1ki9A:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lr0 | TOLA PROTEIN (Pseudomonasaeruginosa) |
PF13103(TonB_2) | 3 | MET A 97GLN A 98ARG A 102 | None | 1.01A | 5ewzB-1lr0A:undetectable | 5ewzB-1lr0A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rcu | CONSERVEDHYPOTHETICAL PROTEINVT76 (Thermotogamaritima) |
PF03641(Lysine_decarbox) | 3 | MET A 88GLN A 87ARG A 89 | None | 1.08A | 5ewzB-1rcuA:undetectable | 5ewzB-1rcuA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s5j | DNA POLYMERASE I (Sulfolobussolfataricus) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | MET A 210GLN A 209ARG A 208 | None | 1.06A | 5ewzB-1s5jA:2.5 | 5ewzB-1s5jA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to3 | PUTATIVE ALDOLASEYIHT (Salmonellaenterica) |
PF01791(DeoC) | 3 | MET A 27GLN A 23ARG A 24 | NonePO4 A 304 (-3.9A)None | 0.97A | 5ewzB-1to3A:undetectable | 5ewzB-1to3A:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to3 | PUTATIVE ALDOLASEYIHT (Salmonellaenterica) |
PF01791(DeoC) | 3 | MET A 141GLN A 137ARG A 138 | None | 1.04A | 5ewzB-1to3A:undetectable | 5ewzB-1to3A:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u70 | DIHYDROFOLATEREDUCTASE (Mus musculus) |
PF00186(DHFR_1) | 3 | MET A 139GLN A 12ARG A 137 | None | 1.05A | 5ewzB-1u70A:undetectable | 5ewzB-1u70A:24.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xgy | K42-41L FAB LIGHTCHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | MET L 4GLN L 6ARG L 24 | None | 1.11A | 5ewzB-1xgyL:undetectable | 5ewzB-1xgyL:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yio | RESPONSE REGULATORYPROTEIN (Pseudomonasfluorescens) |
PF00072(Response_reg)PF00196(GerE) | 3 | MET A 182GLN A 183ARG A 188 | None | 1.06A | 5ewzB-1yioA:undetectable | 5ewzB-1yioA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2db6 | SH3 AND CYSTEINERICH DOMAIN 3 (Homo sapiens) |
PF00130(C1_1) | 3 | MET A 65GLN A 66ARG A 67 | None | 0.99A | 5ewzB-2db6A:undetectable | 5ewzB-2db6A:16.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gw1 | MITOCHONDRIALPRECURSOR PROTEINSIMPORT RECEPTOR (Saccharomycescerevisiae) |
PF00515(TPR_1)PF13181(TPR_8)PF13432(TPR_16) | 3 | MET A 551GLN A 554ARG A 209 | None | 0.66A | 5ewzB-2gw1A:4.8 | 5ewzB-2gw1A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwf | RING FINGER PROTEIN41 (Homo sapiens) |
PF08941(USP8_interact) | 3 | MET B 267GLN B 266ARG B 265 | None | 0.89A | 5ewzB-2gwfB:undetectable | 5ewzB-2gwfB:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h7v | PROTEIN KINASE YPKA (Yersiniapseudotuberculosis) |
PF09632(Rac1) | 3 | MET C 664GLN C 663ARG C 662 | None | 1.02A | 5ewzB-2h7vC:4.5 | 5ewzB-2h7vC:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2huf | ALANINE GLYOXYLATEAMINOTRANSFERASE (Aedes aegypti) |
PF00266(Aminotran_5) | 3 | MET A 190GLN A 66ARG A 194 | None | 0.96A | 5ewzB-2hufA:undetectable | 5ewzB-2hufA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j6h | GLUCOSAMINE-FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE (Escherichiacoli) |
PF01380(SIS)PF13522(GATase_6) | 3 | MET A 447GLN A 446ARG A 443 | None | 0.82A | 5ewzB-2j6hA:2.3 | 5ewzB-2j6hA:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ldi | ZINC-TRANSPORTINGATPASE (Synechocystissp. PCC 6803) |
PF00403(HMA) | 3 | MET A 12GLN A 11ARG A 47 | None | 1.04A | 5ewzB-2ldiA:undetectable | 5ewzB-2ldiA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m7a | UNCHARACTERIZEDPROTEIN (Escherichiacoli) |
no annotation | 3 | MET A 21GLN A 22ARG A 32 | None | 0.87A | 5ewzB-2m7aA:undetectable | 5ewzB-2m7aA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p7n | PATHOGENICITY ISLAND1 EFFECTOR PROTEIN (Chromobacteriumviolaceum) |
PF06511(IpaD) | 3 | MET A 221GLN A 220ARG A 84 | None | 1.08A | 5ewzB-2p7nA:undetectable | 5ewzB-2p7nA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vqa | SLL1358 PROTEIN (Synechocystissp. PCC 6803) |
PF00190(Cupin_1) | 3 | MET A 279GLN A 281ARG A 280 | NoneNoneACT A1395 (-4.1A) | 1.10A | 5ewzB-2vqaA:undetectable | 5ewzB-2vqaA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3z | PUTATIVE DEACETYLASE (Streptococcusmutans) |
PF01522(Polysacc_deac_1) | 3 | MET A 96GLN A 95ARG A 94 | None | 1.00A | 5ewzB-2w3zA:undetectable | 5ewzB-2w3zA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yb4 | AMIDOHYDROLASE (Chromobacteriumviolaceum) |
PF02811(PHP) | 3 | MET A 106GLN A 105ARG A 104 | None | 1.12A | 5ewzB-2yb4A:undetectable | 5ewzB-2yb4A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yn7 | OUTER SURFACEPROTEIN (Borreliellaburgdorferi) |
PF05714(Borrelia_lipo_1) | 3 | MET A 396GLN A 397ARG A 400 | None | 0.80A | 5ewzB-2yn7A:3.1 | 5ewzB-2yn7A:25.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv2 | SUCCINYL-COASYNTHETASE ALPHACHAIN (Aeropyrumpernix) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 3 | MET A 170GLN A 174ARG A 173 | None | 1.09A | 5ewzB-2yv2A:undetectable | 5ewzB-2yv2A:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b0z | FLAGELLARBIOSYNTHETIC PROTEINFLHB (Salmonellaenterica) |
PF01312(Bac_export_2) | 3 | MET A 247GLN A 246ARG A 245 | None | 0.87A | 5ewzB-3b0zA:undetectable | 5ewzB-3b0zA:12.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bo6 | HYDROPHILIC PROTEIN,VIRA PROTEIN (Chromobacteriumviolaceum) |
PF03536(VRP3) | 3 | MET A 47GLN A 46ARG A 45 | None | 0.97A | 5ewzB-3bo6A:undetectable | 5ewzB-3bo6A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bt5 | UNCHARACTERIZEDPROTEIN DUF305 (Deinococcusradiodurans) |
PF03713(DUF305) | 3 | MET A 81GLN A 80ARG A 79 | NoneNone CL A 200 (-4.4A) | 1.00A | 5ewzB-3bt5A:5.0 | 5ewzB-3bt5A:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cv2 | MALATE SYNTHASE A (Escherichiacoli) |
PF01274(Malate_synthase) | 3 | MET A 258GLN A 257ARG A 74 | None | 0.82A | 5ewzB-3cv2A:undetectable | 5ewzB-3cv2A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8x | THIOREDOXINREDUCTASE 1 (Saccharomycescerevisiae) |
PF07992(Pyr_redox_2) | 3 | MET A 71GLN A 74ARG A 70 | None | 1.09A | 5ewzB-3d8xA:undetectable | 5ewzB-3d8xA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gag | PUTATIVE NADHDEHYDROGENASE, NADPHNITROREDUCTASE (Streptococcusmutans) |
PF00881(Nitroreductase) | 3 | MET A 143GLN A 144ARG A 147 | None | 0.75A | 5ewzB-3gagA:undetectable | 5ewzB-3gagA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0d | CTSR (Geobacillusstearothermophilus) |
PF05848(CtsR) | 3 | MET A 123GLN A 95ARG A 135 | NoneNonePO4 A 157 (-3.9A) | 1.09A | 5ewzB-3h0dA:3.1 | 5ewzB-3h0dA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-PROCESSINGPROTEIN 45 (Schizosaccharomycespombe) |
PF02731(SKIP_SNW) | 3 | MET M 312GLN M 314ARG M 313 | None | 0.98A | 5ewzB-3jb9M:undetectable | 5ewzB-3jb9M:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jcx | FAB E LIGHT CHAIN (Rattusnorvegicus) |
PF07686(V-set) | 3 | MET L 76GLN L 77ARG L 59 | None | 0.93A | 5ewzB-3jcxL:undetectable | 5ewzB-3jcxL:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k70 | EXODEOXYRIBONUCLEASEV ALPHA CHAIN (Escherichiacoli) |
PF13538(UvrD_C_2)PF13604(AAA_30) | 3 | MET D 462GLN D 463ARG D 466 | None | 0.75A | 5ewzB-3k70D:undetectable | 5ewzB-3k70D:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lyr | TRANSCRIPTION FACTORCOE1 (Homo sapiens) |
PF16422(COE1_DBD) | 3 | MET A 31GLN A 32ARG A 121 | None | 0.98A | 5ewzB-3lyrA:undetectable | 5ewzB-3lyrA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4p | ASPARAGINYL-TRNASYNTHETASE, PUTATIVE (Entamoebahistolytica) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 3 | MET A 330GLN A 329ARG A 328 | None | 1.06A | 5ewzB-3m4pA:undetectable | 5ewzB-3m4pA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m9v | FAD-DEPENDENTOXIDOREDUCTASE (Actinomadurakijaniata) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 3 | MET A 334GLN A 333ARG A 332 | None | 1.07A | 5ewzB-3m9vA:4.8 | 5ewzB-3m9vA:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mil | ISOAMYLACETATE-HYDROLYZINGESTERASE (Saccharomycescerevisiae) |
PF13472(Lipase_GDSL_2) | 3 | MET A 105GLN A 104ARG A 103 | None | 1.11A | 5ewzB-3milA:undetectable | 5ewzB-3milA:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ni7 | BACTERIAL REGULATORYPROTEINS, TETRFAMILY (Nitrosomonaseuropaea) |
PF00440(TetR_N)PF08511(COQ9) | 3 | MET A 105GLN A 104ARG A 103 | None | 1.04A | 5ewzB-3ni7A:undetectable | 5ewzB-3ni7A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odw | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 1 (Homo sapiens) |
PF00621(RhoGEF) | 3 | MET A 479GLN A 483ARG A 482 | None | 1.02A | 5ewzB-3odwA:2.5 | 5ewzB-3odwA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odx | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 1 (Homo sapiens) |
PF00621(RhoGEF) | 3 | MET A 479GLN A 483ARG A 482 | None | 1.01A | 5ewzB-3odxA:2.5 | 5ewzB-3odxA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oql | TENA HOMOLOG (Pseudomonassyringae groupgenomosp. 3) |
PF14518(Haem_oxygenas_2) | 3 | MET A 44GLN A 43ARG A 45 | None | 1.02A | 5ewzB-3oqlA:2.7 | 5ewzB-3oqlA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4t | ACTIVIN RECEPTORTYPE-2A (Homo sapiens) |
PF00069(Pkinase) | 3 | MET A 482GLN A 481ARG A 484 | None | 1.02A | 5ewzB-3q4tA:undetectable | 5ewzB-3q4tA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgk | FUSION OF UREASEBETA AND GAMMASUBUNITSUREASE SUBUNIT BETA2 (Helicobactermustelae;Helicobactermustelae) |
PF00547(Urease_gamma)PF00699(Urease_beta)PF00449(Urease_alpha)PF01979(Amidohydro_1) | 3 | MET C 103GLN C 104ARG A 165 | None | 1.05A | 5ewzB-3qgkC:undetectable | 5ewzB-3qgkC:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t0y | NEPR (Caulobactervibrioides) |
no annotation | 3 | MET B 41GLN B 40ARG B 39 | None | 1.04A | 5ewzB-3t0yB:undetectable | 5ewzB-3t0yB:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ue1 | PENICILLIN-BINDINGPROTEIN 1A (Acinetobacterbaumannii) |
PF00905(Transpeptidase)PF00912(Transgly)PF17092(PCB_OB) | 3 | MET A 177GLN A 176ARG A 203 | None | 0.79A | 5ewzB-3ue1A:undetectable | 5ewzB-3ue1A:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wcz | ALDO-KETO REDUCTASE2E (Bombyx mori) |
PF00248(Aldo_ket_red) | 3 | MET A 143GLN A 144ARG A 147 | None | 1.08A | 5ewzB-3wczA:undetectable | 5ewzB-3wczA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zjk | BETA GLYCOSIDASE (Thermusthermophilus) |
PF00232(Glyco_hydro_1) | 3 | MET A 66GLN A 67ARG A 72 | None | 0.98A | 5ewzB-3zjkA:undetectable | 5ewzB-3zjkA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci6 | PROTEIN KINASE YOPO (Yersiniaenterocolitica) |
PF00069(Pkinase)PF09632(Rac1) | 3 | MET B 661GLN B 660ARG B 659 | None | 0.92A | 5ewzB-4ci6B:7.0 | 5ewzB-4ci6B:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cyj | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN3-LIKE PROTEIN (Chaetomiumthermophilum) |
no annotation | 3 | MET A 619GLN A 618ARG A 617 | None | 1.00A | 5ewzB-4cyjA:undetectable | 5ewzB-4cyjA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fkz | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Bacillussubtilis) |
PF02350(Epimerase_2) | 3 | MET A 140GLN A 139ARG A 138 | None | 1.05A | 5ewzB-4fkzA:2.2 | 5ewzB-4fkzA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv5 | ASPARTATECARBAMOYLTRANSFERASE, PUTATIVE (Trypanosomacruzi) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | MET A 311GLN A 310ARG A 309 | None | 1.06A | 5ewzB-4iv5A:undetectable | 5ewzB-4iv5A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jnt | ENVELOPEGLYCOPROTEIN E2 (Pestivirus A) |
PF16329(Pestivirus_E2) | 3 | MET A1011GLN A1009ARG A1003 | None | 1.07A | 5ewzB-4jntA:undetectable | 5ewzB-4jntA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jpp | MINOR SPIKE PROTEINH (Escherichiavirus phiX174) |
PF04687(Microvir_H) | 3 | MET A 232GLN A 231ARG A 230 | None | 0.90A | 5ewzB-4jppA:undetectable | 5ewzB-4jppA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgl | GLYCINEDEHYDROGENASE[DECARBOXYLATING] (Synechocystissp. PCC 6803) |
PF02347(GDC-P) | 3 | MET A 48GLN A 47ARG A 46 | None | 0.88A | 5ewzB-4lglA:undetectable | 5ewzB-4lglA:11.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nmn | REPLICATIVE DNAHELICASE (Aquifexaeolicus) |
PF00772(DnaB)PF03796(DnaB_C) | 3 | MET A 245GLN A 242ARG A 246 | NoneNoneADP A1001 (-2.6A) | 1.04A | 5ewzB-4nmnA:2.9 | 5ewzB-4nmnA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oro | POLYMERASE PB2 (Influenza Bvirus) |
PF00604(Flu_PB2) | 3 | MET A 412GLN A 414ARG A 417 | None | 1.11A | 5ewzB-4oroA:undetectable | 5ewzB-4oroA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pvg | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPE 11 (Homo sapiens) |
PF00102(Y_phosphatase) | 3 | MET A 496GLN A 495ARG A 498 | None | 1.12A | 5ewzB-4pvgA:undetectable | 5ewzB-4pvgA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpm | MITOTIC CHECKPOINTSERINE/THREONINE-PROTEIN KINASE BUB1 (Homo sapiens) |
PF00069(Pkinase) | 3 | MET A 904GLN A 907ARG A1051 | NoneNone CL A1504 ( 4.9A) | 1.10A | 5ewzB-4qpmA:2.3 | 5ewzB-4qpmA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rd9 | AMYLOID-LIKE PROTEIN1 (Homo sapiens) |
PF12925(APP_E2) | 3 | MET A 445GLN A 444ARG A 446 | None | 0.93A | 5ewzB-4rd9A:6.3 | 5ewzB-4rd9A:25.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rpd | CAPSID PROTEIN (Norwalk virus) |
PF08435(Calici_coat_C) | 3 | MET A 303GLN A 304ARG A 289 | None | 1.00A | 5ewzB-4rpdA:undetectable | 5ewzB-4rpdA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rz2 | SITE-DETERMININGPROTEIN (Geobacillusthermodenitrificans) |
PF10609(ParA) | 3 | MET A 258GLN A 257ARG A 256 | None | 1.04A | 5ewzB-4rz2A:undetectable | 5ewzB-4rz2A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u7i | SPARTIN (Homo sapiens) |
PF04212(MIT) | 3 | MET A 77GLN A 76ARG A 75 | None | 1.02A | 5ewzB-4u7iA:7.3 | 5ewzB-4u7iA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xef | PROTEIN-TYROSINEKINASE 2-BETA (Homo sapiens) |
PF03623(Focal_AT) | 3 | MET A 976GLN A 975ARG A 974 | None | 1.09A | 5ewzB-4xefA:3.6 | 5ewzB-4xefA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xev | FUSION PROTEIN OFPROTEIN-TYROSINEKINASE 2-BETA FATDOMAIN AND LEUPAXINLD1 MOTIF (Homo sapiens) |
PF03623(Focal_AT) | 3 | MET A 976GLN A 975ARG A 974 | None | 1.05A | 5ewzB-4xevA:3.7 | 5ewzB-4xevA:25.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpd | N-TERMINALACETYLTRANSFERASE ACOMPLEX SUBUNIT NAT1 (Saccharomycescerevisiae) |
PF12569(NARP1) | 3 | MET A 618GLN A 617ARG A 723 | None | 0.99A | 5ewzB-4xpdA:6.2 | 5ewzB-4xpdA:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ds0 | PEPTIDASE M42 (Thaumarchaeotaarchaeon SCGCAB-539-E09) |
PF05343(Peptidase_M42) | 3 | MET A 195GLN A 198ARG A 193 | None | 0.98A | 5ewzB-5ds0A:undetectable | 5ewzB-5ds0A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6s | INTEGRIN ALPHA-L (Homo sapiens) |
PF00092(VWA)PF01839(FG-GAP)PF08441(Integrin_alpha2) | 3 | MET A 405GLN A 403ARG A 407 | None | 0.88A | 5ewzB-5e6sA:undetectable | 5ewzB-5e6sA:14.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exp | TRANSCRIPTIONALREGULATOR FLEQ (Pseudomonasaeruginosa) |
PF00158(Sigma54_activat) | 3 | MET A 159GLN A 158ARG A 157 | None | 1.12A | 5ewzB-5expA:undetectable | 5ewzB-5expA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exr | DNA POLYMERASE ALPHASUBUNIT B (Homo sapiens) |
PF04042(DNA_pol_E_B)PF08418(Pol_alpha_B_N) | 3 | MET D 341GLN D 339ARG D 185 | None | 0.93A | 5ewzB-5exrD:undetectable | 5ewzB-5exrD:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ez7 | FLAVOENZYME PA4991 (Pseudomonasaeruginosa) |
PF01266(DAO) | 3 | MET A 230GLN A 287ARG A 313 | FAD A 401 (-3.6A)NoneNone | 0.89A | 5ewzB-5ez7A:undetectable | 5ewzB-5ez7A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fl7 | ATP SYNTHASE SUBUNITALPHA (Yarrowialipolytica) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 3 | MET A 307GLN A 306ARG A 305 | None | 0.78A | 5ewzB-5fl7A:undetectable | 5ewzB-5fl7A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gq1 | GENOME POLYPROTEIN (Enterovirus A) |
PF00910(RNA_helicase) | 3 | MET A 193GLN A 192ARG A 241 | None | 0.83A | 5ewzB-5gq1A:undetectable | 5ewzB-5gq1A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5izt | OUTER SURFACEPROTEIN (Borreliellaburgdorferi) |
PF05714(Borrelia_lipo_1) | 3 | MET A 396GLN A 397ARG A 400 | None | 0.96A | 5ewzB-5iztA:3.1 | 5ewzB-5iztA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jij | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Mycolicibacteriumthermoresistibile) |
PF00982(Glyco_transf_20) | 3 | MET A 450GLN A 419ARG A 449 | NoneNoneEDO A 508 (-3.1A) | 1.08A | 5ewzB-5jijA:2.1 | 5ewzB-5jijA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jq9 | DIHYDROPTEROATESYNTHASE (Yersinia pestis) |
PF00809(Pterin_bind) | 3 | MET A 223GLN A 226ARG A 235 | None | 1.05A | 5ewzB-5jq9A:undetectable | 5ewzB-5jq9A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kyv | LUCIFERIN4-MONOOXYGENASE (Photinuspyralis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | MET A 118GLN A 122ARG A 77 | None | 1.11A | 5ewzB-5kyvA:undetectable | 5ewzB-5kyvA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltm | PHENYLALANINEAMMONIA LYASE (Anabaena) |
no annotation | 3 | MET B 481GLN B 485ARG B 516 | None | 0.84A | 5ewzB-5ltmB:3.0 | 5ewzB-5ltmB:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mdq | CHITOPORIN (Vibrio harveyi) |
no annotation | 3 | MET A 48GLN A 49ARG A 32 | None | 1.01A | 5ewzB-5mdqA:undetectable | 5ewzB-5mdqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mps | SMALL NUCLEARRIBONUCLEOPROTEIN SMD1 (Saccharomycescerevisiae) |
PF02847(MA3) | 3 | MET h 36GLN h 35ARG h 88 | U 5 173 ( 4.6A) U 5 172 ( 3.8A) U 5 171 ( 2.9A) | 1.09A | 5ewzB-5mpsh:undetectable | 5ewzB-5mpsh:19.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n6n | PROTEIN BMH1 (Saccharomycescerevisiae) |
no annotation | 3 | MET A 223GLN A 224ARG A 227 | None | 0.85A | 5ewzB-5n6nA:31.8 | 5ewzB-5n6nA:67.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n77 | MAGNESIUM TRANSPORTPROTEIN CORA (Escherichiacoli) |
PF01544(CorA) | 3 | MET A 124GLN A 122ARG A 11 | None | 0.69A | 5ewzB-5n77A:4.2 | 5ewzB-5n77A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9y | ZINC TRANSPORTPROTEIN ZNTB (Escherichiacoli) |
no annotation | 3 | MET A 227GLN A 223ARG A 224 | None | 0.92A | 5ewzB-5n9yA:3.8 | 5ewzB-5n9yA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnn | CTATC (Chaetomiumthermophilum) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | MET A2237GLN A2236ARG A2235 | None | 1.04A | 5ewzB-5nnnA:undetectable | 5ewzB-5nnnA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ool | 39S RIBOSOMALPROTEIN L45,MITOCHONDRIAL (Homo sapiens) |
PF00181(Ribosomal_L2)PF03947(Ribosomal_L2_C) | 3 | MET d 57GLN d 58ARG d 61 | None | 0.99A | 5ewzB-5oold:undetectable | 5ewzB-5oold:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tw1 | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Mycolicibacteriumsmegmatis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF10385(RNA_pol_Rpb2_45) | 3 | MET C 577GLN C 576ARG C 575 | None | 0.90A | 5ewzB-5tw1C:undetectable | 5ewzB-5tw1C:11.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uhd | RNA POLYMERASE SIGMAFACTOR SIGA (Mycobacteriumtuberculosis) |
PF00140(Sigma70_r1_2)PF04539(Sigma70_r3)PF04542(Sigma70_r2)PF04545(Sigma70_r4) | 3 | MET F 281GLN F 277ARG F 278 | None | 1.10A | 5ewzB-5uhdF:4.8 | 5ewzB-5uhdF:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5umg | DIHYDROPTEROATESYNTHASE (Klebsiellapneumoniae) |
PF00809(Pterin_bind) | 3 | MET A 223GLN A 226ARG A 235 | None | 1.00A | 5ewzB-5umgA:undetectable | 5ewzB-5umgA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5umu | FACT COMPLEX SUBUNITSPT16 (Homo sapiens) |
no annotation | 3 | MET A 676GLN A 677ARG A 675 | NoneNoneFMT A1009 ( 4.6A) | 1.12A | 5ewzB-5umuA:undetectable | 5ewzB-5umuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ur2 | BIFUNCTIONAL PROTEINPUTA (Bdellovibriobacteriovorus) |
PF00171(Aldedh)PF01619(Pro_dh) | 3 | MET A 19GLN A 22ARG A 18 | None | 1.08A | 5ewzB-5ur2A:2.7 | 5ewzB-5ur2A:12.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x04 | DODECANOYL-[ACYL-CARRIER-PROTEIN]HYDROLASE,CHLOROPLASTIC (Umbellulariacalifornica) |
no annotation | 3 | MET A 133GLN A 134ARG A 199 | None | 0.78A | 5ewzB-5x04A:undetectable | 5ewzB-5x04A:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c0t | CGMP-DEPENDENTPROTEIN KINASE 1 (Homo sapiens) |
no annotation | 3 | MET A 413GLN A 414ARG A 423 | None | 0.70A | 5ewzB-6c0tA:undetectable | 5ewzB-6c0tA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c90 | EXOSOME RNA HELICASEMTR4,EXOSOME RNAHELICASE MTR4 (Homo sapiens) |
no annotation | 3 | MET A 935GLN A 934ARG A 933 | None | 1.11A | 5ewzB-6c90A:2.2 | 5ewzB-6c90A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fa5 | PUTATIVE MRNASPLICING FACTOR (Chaetomiumthermophilum) |
no annotation | 3 | MET A 715GLN A 714ARG A 713 | None | 0.97A | 5ewzB-6fa5A:undetectable | 5ewzB-6fa5A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 3 | MET A 56GLN A 54ARG A 64 | 3TL A 201 (-4.7A)3TL A 201 ( 4.1A)None | 1.11A | 5ewzB-6fivA:undetectable | 5ewzB-6fivA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g72 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN2 (Mus musculus) |
no annotation | 3 | MET N 175GLN N 174ARG N 176 | None | 0.88A | 5ewzB-6g72N:2.6 | 5ewzB-6g72N:undetectable |