SIMILAR PATTERNS OF AMINO ACIDS FOR 5EWU_B_BEZB1401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
154l GOOSE LYSOZYME

(Anser anser) 		PF01464
(SLT) 		4 GLY A  15
THR A  13
SER A  34
VAL A  31
 None
 1.13A 5ewuB-154lA:
undetectable		 5ewuB-154lA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 GLY A 274
THR A 275
SER A 266
VAL A 244
 None
 1.08A 5ewuB-1airA:
undetectable		 5ewuB-1airA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A  74
THR A  75
VAL A  58
HIS A 104
 None
None
None
CU  A 556 (-3.1A)
 0.94A 5ewuB-1asoA:
undetectable		 5ewuB-1asoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs6 AXONIN-1

(Gallus gallus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 TRP A 123
GLY A 124
THR A 171
VAL A 125
 None
 1.14A 5ewuB-1cs6A:
undetectable		 5ewuB-1cs6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		4 GLY A 290
THR A 293
SER A 285
HIS A 325
 None
 1.12A 5ewuB-1g8pA:
undetectable		 5ewuB-1g8pA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TRP A 236
GLY A  36
THR A  35
VAL A  39
 None
None
FAD  A 600 (-2.8A)
None
 1.09A 5ewuB-1gpeA:
undetectable		 5ewuB-1gpeA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 528
SER A 530
VAL A 531
HIS A 637
 None
 1.03A 5ewuB-1h17A:
undetectable		 5ewuB-1h17A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 240
THR A 239
VAL A 426
HIS A 451
 None
None
None
CU  A 702 (-3.2A)
 1.12A 5ewuB-1hfuA:
undetectable		 5ewuB-1hfuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2z ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Helicobacter
pylori) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 GLY A  65
THR A  66
VAL A  63
HIS A 118
 None
SO4  A 412 (-4.2A)
None
SOG  A 409 (-3.9A)
 1.11A 5ewuB-1j2zA:
undetectable		 5ewuB-1j2zA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ki9 ADENYLATE KINASE

(Methanothermococcus
thermolithotrophicus) 		PF13207
(AAA_17) 		4 GLY A  16
THR A  17
VAL A   8
HIS A  92
 None
 1.14A 5ewuB-1ki9A:
undetectable		 5ewuB-1ki9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 GLY A  23
THR A  24
SER A 313
VAL A  22
 None
 1.09A 5ewuB-1px8A:
undetectable		 5ewuB-1px8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 GLY A1115
SER A1117
VAL A1118
HIS A1095
 ANP  A1500 (-3.4A)
MG  A1501 (-2.9A)
None
None
 1.08A 5ewuB-1s16A:
undetectable		 5ewuB-1s16A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE

(Mycobacterium
tuberculosis) 		PF01451
(LMWPc) 		4 GLY A  44
THR A  45
SER A  18
VAL A  10
 None
 1.03A 5ewuB-1u2qA:
undetectable		 5ewuB-1u2qA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 GLY B 900
SER B 908
VAL B 901
HIS B 915
 None
 0.83A 5ewuB-1uw4B:
1.9		 5ewuB-1uw4B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		4 GLY A 375
THR A 374
SER A 379
HIS A 371
 None
 1.06A 5ewuB-1vpeA:
undetectable		 5ewuB-1vpeA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		4 GLY B 228
SER B 185
VAL B 186
HIS B  81
 PLP  B 400 (-4.0A)
PLP  B 400 (-3.0A)
None
PLP  B 400 (-3.9A)
 1.06A 5ewuB-1wdwB:
2.6		 5ewuB-1wdwB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhd PUTATIVE
ACETYLTRANSFERASE/AC
YLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 GLY A  26
THR A  25
VAL A  28
HIS A  64
 None
None
None
SO4  A 201 (-3.6A)
 1.05A 5ewuB-1xhdA:
undetectable		 5ewuB-1xhdA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D

(Methanosarcina
mazei) 		PF01142
(TruD) 		4 GLY A 383
THR A 384
SER A 381
HIS A 271
 None
 0.95A 5ewuB-1z2zA:
undetectable		 5ewuB-1z2zA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Homo sapiens) 		PF00551
(Formyl_trans_N) 		4 GLY A 133
THR A 132
VAL A 169
HIS A 108
 None
 1.06A 5ewuB-1zlyA:
undetectable		 5ewuB-1zlyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		4 GLY A  33
THR A  32
VAL A  83
HIS A  36
 None
 1.11A 5ewuB-2a4mA:
undetectable		 5ewuB-2a4mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		4 GLY A  33
THR A  32
VAL A  83
HIS A  39
 None
 1.10A 5ewuB-2a4mA:
undetectable		 5ewuB-2a4mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anu HYPOTHETICAL PROTEIN
TM0559

(Thermotoga
maritima) 		no annotation 4 GLY A  95
SER A  41
VAL A 110
HIS A  13
 None
None
None
ZN  A 405 ( 3.3A)
 1.12A 5ewuB-2anuA:
undetectable		 5ewuB-2anuA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 GLY A  23
THR A  24
SER A 314
VAL A  22
 None
 1.12A 5ewuB-2bs9A:
undetectable		 5ewuB-2bs9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		4 GLY A  43
SER A 259
VAL A  38
HIS A 235
 None
None
None
MG  A 401 (-3.2A)
 1.07A 5ewuB-2cw6A:
undetectable		 5ewuB-2cw6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Thermus
thermophilus) 		PF01451
(LMWPc) 		4 GLY A  44
THR A  45
SER A  18
VAL A  10
 None
 1.02A 5ewuB-2cwdA:
undetectable		 5ewuB-2cwdA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		4 GLY A 125
THR A  59
VAL A 128
HIS A 138
 HEA  A 515 (-3.2A)
None
None
None
 1.08A 5ewuB-2eijA:
undetectable		 5ewuB-2eijA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 TRP A  84
GLY A  85
THR A  86
VAL A 115
 None
 1.13A 5ewuB-2fk7A:
undetectable		 5ewuB-2fk7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		4 GLY A  17
SER A 233
VAL A  12
HIS A 209
 None
None
None
NA  A3000 (-3.7A)
 1.03A 5ewuB-2ftpA:
undetectable		 5ewuB-2ftpA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 GLY A 824
THR A 825
SER A 800
VAL A 843
 None
 1.02A 5ewuB-2g28A:
undetectable		 5ewuB-2g28A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj4 ACETYLGLUTAMATE
KINASE

(Synechococcus
elongatus) 		PF00696
(AA_kinase) 		4 GLY A 130
THR A 131
SER A 173
VAL A 175
 None
 0.98A 5ewuB-2jj4A:
undetectable		 5ewuB-2jj4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jza NITRITE REDUCTASE
[NAD(P)H] SMALL
SUBUNIT

(Pectobacterium
atrosepticum) 		PF13806
(Rieske_2) 		4 GLY A  18
THR A  17
SER A  52
VAL A  19
 None
 0.85A 5ewuB-2jzaA:
undetectable		 5ewuB-2jzaA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcp IGA-KAPPA MCPC603
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  10
THR H 119
SER H 212
HIS H 210
 None
 1.09A 5ewuB-2mcpH:
undetectable		 5ewuB-2mcpH:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 GLY A 201
SER A 205
VAL A 202
HIS A 287
 GLY  A 201 ( 0.0A)
SER  A 205 ( 0.0A)
VAL  A 202 ( 0.6A)
HIS  A 287 ( 1.0A)
 1.06A 5ewuB-2ogsA:
undetectable		 5ewuB-2ogsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		4 GLY A 125
THR A 126
SER A 242
VAL A 244
 None
None
F6P  A 603 ( 4.7A)
None
 1.09A 5ewuB-2owzA:
undetectable		 5ewuB-2owzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		4 GLY A 335
THR A 336
SER A 121
HIS A 191
 None
 0.93A 5ewuB-2puzA:
undetectable		 5ewuB-2puzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 GLY A 339
THR A 338
SER A 308
VAL A 340
 None
 1.12A 5ewuB-2qneA:
undetectable		 5ewuB-2qneA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 GLY A  73
THR A  74
SER A  98
VAL A  67
 None
 1.14A 5ewuB-2rbcA:
undetectable		 5ewuB-2rbcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 TRP A 618
GLY A 326
SER A 251
VAL A 247
 None
 0.97A 5ewuB-2vcaA:
undetectable		 5ewuB-2vcaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		4 GLY A 114
THR A 115
SER A  56
VAL A  55
 None
 1.00A 5ewuB-2w1jA:
undetectable		 5ewuB-2w1jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		4 TRP A  69
GLY A  81
SER A  78
VAL A  45
 None
 1.13A 5ewuB-2whxA:
undetectable		 5ewuB-2whxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 GLY A 604
THR A 379
VAL A 191
HIS A 247
 None
None
None
ZN  A1637 ( 3.2A)
 1.06A 5ewuB-2ycbA:
undetectable		 5ewuB-2ycbA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta) 		4 GLY B  79
SER B 106
VAL B  59
HIS B  66
 None
 1.11A 5ewuB-2zpbB:
undetectable		 5ewuB-2zpbB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 TRP A 235
GLY A 236
SER A 305
VAL A 239
 None
 1.07A 5ewuB-3bjdA:
undetectable		 5ewuB-3bjdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvi PROTEIN TYROSINE
PHOSPHATASE

(Entamoeba
histolytica) 		PF01451
(LMWPc) 		4 GLY A  40
THR A  41
SER A  14
VAL A   6
 None
None
SO4  A 201 (-3.2A)
None
 1.02A 5ewuB-3jviA:
undetectable		 5ewuB-3jviA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 GLY A 182
THR A 183
SER A  10
VAL A  14
 None
 1.10A 5ewuB-3k9dA:
undetectable		 5ewuB-3k9dA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		4 GLY A 702
THR A 703
SER A 667
HIS A 618
 B12  A1801 (-3.1A)
B12  A1801 (-3.2A)
B12  A1801 (-2.5A)
B12  A1801 (-3.7A)
 0.94A 5ewuB-3koyA:
undetectable		 5ewuB-3koyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwy URIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		4 GLY A 155
THR A 126
SER A 108
VAL A 105
 None
 0.88A 5ewuB-3nwyA:
undetectable		 5ewuB-3nwyA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY A  69
SER A   7
VAL A  70
HIS A  46
 None
 1.06A 5ewuB-3o21A:
3.0		 5ewuB-3o21A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 GLY B 911
THR B 908
SER B 915
VAL B 912
HIS B1030
 None
CL  B1130 ( 4.7A)
None
None
None
 1.27A 5ewuB-3p8cB:
undetectable		 5ewuB-3p8cB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk1 INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens) 		PF00452
(Bcl-2) 		4 GLY A 217
SER A 269
VAL A 265
HIS A 224
 None
None
None
CD  A   5 (-3.5A)
 1.09A 5ewuB-3pk1A:
undetectable		 5ewuB-3pk1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		4 GLY A  91
THR A  92
VAL A  64
HIS A  24
 None
KCX  A 154 ( 4.4A)
None
ZN  A 333 ( 3.3A)
 0.97A 5ewuB-3pnzA:
undetectable		 5ewuB-3pnzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qta CHEMOTAXIS PROTEIN
CHEC

(Haloarcula
marismortui) 		PF13690
(CheX) 		4 GLY A 118
THR A 116
SER A  27
VAL A  24
 None
 1.15A 5ewuB-3qtaA:
undetectable		 5ewuB-3qtaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2u METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		4 GLY A 118
THR A 120
SER A 178
HIS A 115
 None
 1.05A 5ewuB-3r2uA:
undetectable		 5ewuB-3r2uA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh0 ARSENATE REDUCTASE

(Corynebacterium
glutamicum) 		PF01451
(LMWPc) 		4 GLY A  36
THR A  37
SER A  15
VAL A   7
 OCS  A   8 ( 3.1A)
OCS  A   8 ( 3.6A)
OCS  A   8 ( 2.6A)
OCS  A   8 ( 2.9A)
 1.01A 5ewuB-3rh0A:
undetectable		 5ewuB-3rh0A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rof LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE PTPA

(Staphylococcus
aureus) 		PF01451
(LMWPc) 		4 GLY A  40
THR A  41
SER A  15
VAL A   7
 None
 0.97A 5ewuB-3rofA:
undetectable		 5ewuB-3rofA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4k PUTATIVE ESTERASE
RV1847/MT1895

(Mycobacterium
tuberculosis) 		PF03061
(4HBT) 		4 GLY A  48
THR A  47
SER A  94
VAL A  49
 None
 0.98A 5ewuB-3s4kA:
undetectable		 5ewuB-3s4kA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		4 GLY A 120
THR A 121
VAL A 115
HIS A 175
 None
 1.14A 5ewuB-3vmwA:
undetectable		 5ewuB-3vmwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnp HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00132
(Hexapep) 		4 GLY A  26
THR A  25
VAL A  28
HIS A  64
 None
None
None
MG  A 202 (-3.4A)
 1.08A 5ewuB-3vnpA:
undetectable		 5ewuB-3vnpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		4 GLY A 117
THR A 116
SER A 121
VAL A   9
 GDP  A 999 (-3.5A)
GDP  A 999 (-4.3A)
None
None
 1.13A 5ewuB-3zidA:
2.3		 5ewuB-3zidA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		4 GLY A  71
SER A 112
VAL A 113
HIS A 166
 None
 1.14A 5ewuB-4at0A:
undetectable		 5ewuB-4at0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 TRP A  68
GLY A  51
SER A  63
VAL A  52
 None
 1.04A 5ewuB-4bc5A:
undetectable		 5ewuB-4bc5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 GLY A  91
THR A  94
SER A 125
VAL A 122
 None
 1.11A 5ewuB-4c22A:
undetectable		 5ewuB-4c22A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 TRP A 547
GLY A 803
THR A 802
VAL A 787
 None
 1.06A 5ewuB-4ci8A:
undetectable		 5ewuB-4ci8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 TRP A 608
GLY A 602
THR A 603
VAL A 601
 None
 1.06A 5ewuB-4ci8A:
undetectable		 5ewuB-4ci8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Burkholderia
pseudomallei) 		PF00753
(Lactamase_B) 		4 GLY A 142
THR A 144
SER A 195
HIS A 139
 None
None
None
EDO  A 303 (-4.1A)
 1.05A 5ewuB-4efzA:
undetectable		 5ewuB-4efzA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2

(Danio rerio) 		PF03372
(Exo_endo_phos) 		4 GLY A 270
THR A 272
SER A 127
HIS A 360
 None
 1.01A 5ewuB-4f1hA:
undetectable		 5ewuB-4f1hA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7c CD1D ANTIGEN, D
POLYPEPTIDE

(Bos taurus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 TRP A  63
GLY A  56
THR A  57
VAL A 173
 None
 1.11A 5ewuB-4f7cA:
undetectable		 5ewuB-4f7cA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyl STAGE II SPORULATION
PROTEIN

(Haliangium
ochraceum) 		PF01740
(STAS) 		4 GLY A  18
THR A   1
SER A  50
VAL A  49
 None
 1.06A 5ewuB-4hylA:
undetectable		 5ewuB-4hylA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT

(Enterococcus
faecalis) 		PF02518
(HATPase_c) 		4 GLY A 121
SER A 123
VAL A 124
HIS A 101
 None
 1.02A 5ewuB-4hz5A:
undetectable		 5ewuB-4hz5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 TRP A 519
THR A 200
VAL A 209
HIS A 262
 None
 0.94A 5ewuB-4idmA:
1.8		 5ewuB-4idmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrq PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Vibrio cholerae) 		PF01451
(LMWPc) 		4 GLY A  39
THR A  40
SER A  15
VAL A   7
 None
 0.99A 5ewuB-4lrqA:
undetectable		 5ewuB-4lrqA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 189
THR A 190
SER A 169
VAL A 104
 None
 0.99A 5ewuB-4ls5A:
undetectable		 5ewuB-4ls5A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nql AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		4 GLY A 390
THR A 393
VAL A 410
HIS A 356
 None
None
None
ZN  A 501 (-3.4A)
 1.10A 5ewuB-4nqlA:
undetectable		 5ewuB-4nqlA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn0 UPF0141 PROTEIN YJDB

(Campylobacter
jejuni) 		PF00884
(Sulfatase) 		4 GLY A 299
THR A 298
VAL A 300
HIS A 216
 None
 0.97A 5ewuB-4tn0A:
undetectable		 5ewuB-4tn0A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		4 GLY A 547
THR A 548
VAL A  67
HIS A 372
 None
 1.02A 5ewuB-4tr2A:
undetectable		 5ewuB-4tr2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE

(Pseudomonas
putida) 		PF00296
(Bac_luciferase) 		4 TRP A 234
GLY A 339
THR A 338
HIS A 253
 None
 0.77A 5ewuB-4uwmA:
undetectable		 5ewuB-4uwmA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 GLY A 464
THR A 463
VAL A 449
HIS A 409
 None
 1.02A 5ewuB-4wjsA:
undetectable		 5ewuB-4wjsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida) 		PF00753
(Lactamase_B) 		4 GLY A 148
THR A 150
SER A 195
HIS A 145
 None
 1.06A 5ewuB-4yslA:
undetectable		 5ewuB-4yslA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd5 AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		4 GLY A 390
THR A 393
VAL A 410
HIS A 356
 None
None
None
ZN  A 502 (-3.2A)
 1.08A 5ewuB-4zd5A:
undetectable		 5ewuB-4zd5A:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 TRP A 985
GLY A 986
SER A1039
VAL A1041
HIS A1174
 None
 0.55A 5ewuB-4zhjA:
58.0		 5ewuB-4zhjA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 TRP A 985
GLY A 986
THR A 987
SER A1039
VAL A1041
 None
 0.86A 5ewuB-4zhjA:
58.0		 5ewuB-4zhjA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		5 TRP A 229
GLY A 371
THR A 368
SER A 375
VAL A 372
 None
 1.39A 5ewuB-5eefA:
2.9		 5ewuB-5eefA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5er3 SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13407
(Peripla_BP_4) 		4 GLY A 125
THR A 122
SER A 130
VAL A 131
 None
 1.10A 5ewuB-5er3A:
2.2		 5ewuB-5er3A:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF02514
(CobN-Mg_chel) 		6 TRP A1033
GLY A1034
THR A1035
SER A1087
VAL A1089
HIS A1223
 None
BEZ  A1401 (-3.6A)
BEZ  A1401 (-2.6A)
BEZ  A1401 (-2.5A)
BEZ  A1401 (-4.0A)
BEZ  A1401 (-3.5A)
 0.43A 5ewuB-5ewuA:
63.2		 5ewuB-5ewuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		4 GLY B 230
SER B 187
VAL B 188
HIS B  83
 PLP  B 501 (-4.0A)
PLP  B 501 (-2.7A)
None
PLP  B 501 (-4.0A)
 1.12A 5ewuB-5ey5B:
2.7		 5ewuB-5ey5B:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 GLY A 394
THR A 393
SER A 289
VAL A 285
 None
None
None
AKR  A 702 ( 4.4A)
 0.99A 5ewuB-5gxdA:
2.4		 5ewuB-5gxdA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 TRP A2027
GLY A2030
VAL A2050
HIS A2055
 None
 1.15A 5ewuB-5h64A:
1.7		 5ewuB-5h64A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H 239
THR H 241
SER H 186
VAL H 189
 None
 0.84A 5ewuB-5iltH:
undetectable		 5ewuB-5iltH:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5p DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 GLY A 123
SER A 125
VAL A 126
HIS A 103
 ANP  A 501 (-3.4A)
NA  A 502 (-3.0A)
None
None
 1.06A 5ewuB-5j5pA:
undetectable		 5ewuB-5j5pA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 GLY A 252
SER A 205
VAL A 215
HIS A 192
 None
 0.84A 5ewuB-5jowA:
undetectable		 5ewuB-5jowA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens) 		PF00452
(Bcl-2) 		4 GLY A 217
SER A 269
VAL A 265
HIS A 224
 None
 1.03A 5ewuB-5jsbA:
undetectable		 5ewuB-5jsbA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 GLY A 413
THR A 412
SER A 247
VAL A 265
 None
 1.12A 5ewuB-5l8sA:
undetectable		 5ewuB-5l8sA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7b PUTATIVE LOW
MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE SLR0328

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY A  40
THR A  41
SER A  14
VAL A   6
 None
 1.05A 5ewuB-5o7bA:
undetectable		 5ewuB-5o7bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN

(Homo sapiens) 		no annotation 4 GLY L 156
THR L 157
SER L 194
HIS L 192
 None
 0.86A 5ewuB-5ocyL:
undetectable		 5ewuB-5ocyL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 GLY B 153
THR B 154
SER B 191
HIS B 189
 None
 0.85A 5ewuB-5odbB:
undetectable		 5ewuB-5odbB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		4 GLY A 444
SER A  23
VAL A  25
HIS A 453
 None
 1.04A 5ewuB-5upyA:
undetectable		 5ewuB-5upyA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 TRP A 466
THR A 374
VAL A 242
HIS A 193
 None
 1.06A 5ewuB-5w21A:
undetectable		 5ewuB-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0i KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		no annotation 4 GLY K 371
THR K 370
SER K 588
HIS K 596
 None
 0.98A 5ewuB-6b0iK:
undetectable		 5ewuB-6b0iK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6daw NON-HEME IRON
HYDROXYLASE

(Streptomyces
lusitanus) 		no annotation 4 GLY A 173
THR A 172
VAL A 174
HIS A 146
 None
ACT  A 403 (-2.9A)
None
ARG  A 402 (-3.2A)
 0.94A 5ewuB-6dawA:
undetectable		 5ewuB-6dawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 GLY A 198
SER A 250
VAL A 246
HIS A 205
 None
None
None
6AK  A 401 ( 4.4A)
 1.00A 5ewuB-6dm8A:
undetectable		 5ewuB-6dm8A:
undetectable