SIMILAR PATTERNS OF AMINO ACIDS FOR 5EWU_A_BEZA1401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
154l GOOSE LYSOZYME

(Anser anser) 		PF01464
(SLT) 		4 GLY A  15
THR A  13
SER A  34
VAL A  31
 None
 0.86A 5ewuA-154lA:
undetectable		 5ewuA-154lA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 GLY A  96
THR A  95
SER A  25
HIS A  57
 None
PPI  A 278 (-3.7A)
None
None
 1.07A 5ewuA-1a8sA:
1.1		 5ewuA-1a8sA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 GLY A 274
THR A 275
SER A 266
VAL A 244
 None
 1.15A 5ewuA-1airA:
undetectable		 5ewuA-1airA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A  74
THR A  75
VAL A  58
HIS A 104
 None
None
None
CU  A 556 (-3.1A)
 1.02A 5ewuA-1asoA:
undetectable		 5ewuA-1asoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs6 AXONIN-1

(Gallus gallus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 TRP A 123
GLY A 124
THR A 171
VAL A 125
 None
 0.99A 5ewuA-1cs6A:
undetectable		 5ewuA-1cs6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1c IMMUNOGLOBULIN-LIKE
DOMAIN I1 FROM TITIN

(Homo sapiens) 		PF07679
(I-set) 		4 GLY A  71
THR A  70
SER A  74
VAL A  96
 None
 1.15A 5ewuA-1g1cA:
undetectable		 5ewuA-1g1cA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8) 		PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C) 		4 GLY C  55
THR C  56
VAL C 185
HIS C  49
 None
 0.86A 5ewuA-1g3nC:
undetectable		 5ewuA-1g3nC:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		4 GLY A 290
THR A 293
SER A 285
HIS A 325
 None
 1.13A 5ewuA-1g8pA:
0.0		 5ewuA-1g8pA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 528
SER A 530
VAL A 531
HIS A 637
 None
 1.02A 5ewuA-1h17A:
1.0		 5ewuA-1h17A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 GLY A1115
SER A1117
VAL A1118
HIS A1095
 ANP  A1500 (-3.4A)
MG  A1501 (-2.9A)
None
None
 1.03A 5ewuA-1s16A:
undetectable		 5ewuA-1s16A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE

(Mycobacterium
tuberculosis) 		PF01451
(LMWPc) 		4 GLY A  44
THR A  45
SER A  18
VAL A  10
 None
 0.99A 5ewuA-1u2qA:
undetectable		 5ewuA-1u2qA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 GLY B 900
SER B 908
VAL B 901
HIS B 915
 None
 0.82A 5ewuA-1uw4B:
3.5		 5ewuA-1uw4B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 GLY A 264
THR A 263
SER A 258
VAL A 257
 None
 1.09A 5ewuA-1vclA:
undetectable		 5ewuA-1vclA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		4 GLY B 228
SER B 185
VAL B 186
HIS B  81
 PLP  B 400 (-4.0A)
PLP  B 400 (-3.0A)
None
PLP  B 400 (-3.9A)
 1.05A 5ewuA-1wdwB:
3.1		 5ewuA-1wdwB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhd PUTATIVE
ACETYLTRANSFERASE/AC
YLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 GLY A  26
THR A  25
VAL A  28
HIS A  64
 None
None
None
SO4  A 201 (-3.6A)
 0.99A 5ewuA-1xhdA:
undetectable		 5ewuA-1xhdA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D

(Methanosarcina
mazei) 		PF01142
(TruD) 		4 GLY A 383
THR A 384
SER A 381
HIS A 271
 None
 0.71A 5ewuA-1z2zA:
undetectable		 5ewuA-1z2zA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anu HYPOTHETICAL PROTEIN
TM0559

(Thermotoga
maritima) 		no annotation 4 GLY A  95
SER A  41
VAL A 110
HIS A  13
 None
None
None
ZN  A 405 ( 3.3A)
 1.12A 5ewuA-2anuA:
undetectable		 5ewuA-2anuA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		4 GLY A  43
SER A 259
VAL A  38
HIS A 235
 None
None
None
MG  A 401 (-3.2A)
 1.12A 5ewuA-2cw6A:
undetectable		 5ewuA-2cw6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Thermus
thermophilus) 		PF01451
(LMWPc) 		4 GLY A  44
THR A  45
SER A  18
VAL A  10
 None
 0.98A 5ewuA-2cwdA:
undetectable		 5ewuA-2cwdA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2x 2-DEOXY-SCYLLO-INOSO
SE SYNTHASE

(Bacillus
circulans) 		PF01761
(DHQ_synthase) 		4 GLY A 102
THR A 128
SER A  41
VAL A 101
 CO  A 603 ( 4.2A)
None
None
None
 1.13A 5ewuA-2d2xA:
2.9		 5ewuA-2d2xA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		4 GLY A  80
THR A  81
SER A 205
VAL A 184
 PLP  A1001 (-3.7A)
PLP  A1001 (-3.6A)
PLP  A1001 (-2.7A)
PLP  A1001 (-4.2A)
 1.06A 5ewuA-2dr1A:
2.6		 5ewuA-2dr1A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 TRP A  84
GLY A  85
THR A  86
VAL A 115
 None
 1.14A 5ewuA-2fk7A:
2.1		 5ewuA-2fk7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 GLY A 274
SER A 359
VAL A 361
HIS A 229
 None
None
None
ZN  A 500 (-3.1A)
 1.11A 5ewuA-2fpqA:
undetectable		 5ewuA-2fpqA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		4 GLY A  17
SER A 233
VAL A  12
HIS A 209
 None
None
None
NA  A3000 (-3.7A)
 1.08A 5ewuA-2ftpA:
undetectable		 5ewuA-2ftpA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 GLY A 824
THR A 825
SER A 800
VAL A 843
 None
 0.86A 5ewuA-2g28A:
1.5		 5ewuA-2g28A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jza NITRITE REDUCTASE
[NAD(P)H] SMALL
SUBUNIT

(Pectobacterium
atrosepticum) 		PF13806
(Rieske_2) 		4 GLY A  18
THR A  17
SER A  52
VAL A  19
 None
 0.92A 5ewuA-2jzaA:
undetectable		 5ewuA-2jzaA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kw1 FAS APOPTOTIC
INHIBITORY MOLECULE
1

(Homo sapiens) 		PF06905
(FAIM1) 		4 GLY A  47
THR A  48
SER A  65
HIS A  75
 None
 1.13A 5ewuA-2kw1A:
undetectable		 5ewuA-2kw1A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A  21
THR A  24
SER A  93
VAL A  20
 None
 1.11A 5ewuA-2o3jA:
4.1		 5ewuA-2o3jA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 GLY A 201
SER A 205
VAL A 202
HIS A 287
 GLY  A 201 ( 0.0A)
SER  A 205 ( 0.0A)
VAL  A 202 ( 0.6A)
HIS  A 287 ( 1.0A)
 1.09A 5ewuA-2ogsA:
undetectable		 5ewuA-2ogsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		4 GLY A 252
SER A 256
VAL A 253
HIS A 246
 None
 1.13A 5ewuA-2p9bA:
undetectable		 5ewuA-2p9bA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 GLY A 339
THR A 338
SER A 308
VAL A 340
 None
 1.12A 5ewuA-2qneA:
undetectable		 5ewuA-2qneA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 TRP A 618
GLY A 326
SER A 251
VAL A 247
 None
 0.94A 5ewuA-2vcaA:
undetectable		 5ewuA-2vcaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		4 GLY A 114
THR A 115
SER A  56
VAL A  55
 None
 0.88A 5ewuA-2w1jA:
undetectable		 5ewuA-2w1jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		4 TRP A  69
GLY A  81
SER A  78
VAL A  45
 None
 1.08A 5ewuA-2whxA:
undetectable		 5ewuA-2whxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 GLY A 604
THR A 379
VAL A 191
HIS A 247
 None
None
None
ZN  A1637 ( 3.2A)
 1.15A 5ewuA-2ycbA:
undetectable		 5ewuA-2ycbA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta) 		4 GLY B  79
SER B 106
VAL B  59
HIS B  66
 None
 1.09A 5ewuA-2zpbB:
undetectable		 5ewuA-2zpbB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 TRP A 235
GLY A 236
SER A 305
VAL A 239
 None
 1.06A 5ewuA-3bjdA:
undetectable		 5ewuA-3bjdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245

(Nitrosomonas
europaea) 		PF17131
(LolA_like) 		4 GLY A 127
THR A 126
SER A 231
VAL A 129
 None
 1.08A 5ewuA-3buuA:
undetectable		 5ewuA-3buuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 270
SER A 301
VAL A 300
HIS A 320
 None
 1.13A 5ewuA-3cyjA:
undetectable		 5ewuA-3cyjA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxk GOOSE-TYPE LYSOZYME
1

(Gadus morhua) 		PF01464
(SLT) 		4 GLY A  15
THR A  13
SER A  34
VAL A  31
 None
 0.87A 5ewuA-3gxkA:
undetectable		 5ewuA-3gxkA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT

(Bacteroides
thetaiotaomicron) 		PF01012
(ETF) 		4 GLY A  95
THR A  97
SER A  18
VAL A  17
 None
 1.12A 5ewuA-3ih5A:
undetectable		 5ewuA-3ih5A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvi PROTEIN TYROSINE
PHOSPHATASE

(Entamoeba
histolytica) 		PF01451
(LMWPc) 		4 GLY A  40
THR A  41
SER A  14
VAL A   6
 None
None
SO4  A 201 (-3.2A)
None
 0.97A 5ewuA-3jviA:
undetectable		 5ewuA-3jviA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 GLY A 182
THR A 183
SER A  10
VAL A  14
 None
 1.04A 5ewuA-3k9dA:
2.9		 5ewuA-3k9dA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		4 GLY A 702
THR A 703
SER A 667
HIS A 618
 B12  A1801 (-3.1A)
B12  A1801 (-3.2A)
B12  A1801 (-2.5A)
B12  A1801 (-3.7A)
 0.89A 5ewuA-3koyA:
undetectable		 5ewuA-3koyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm7 PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE /
2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE

(Yersinia
enterocolitica) 		PF07071
(KDGP_aldolase) 		4 GLY A  98
THR A  97
SER A  77
VAL A  95
 None
 1.03A 5ewuA-3lm7A:
undetectable		 5ewuA-3lm7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyd UNCHARACTERIZED
PROTEIN

(Jonesia
denitrificans) 		PF10738
(Lpp-LpqN) 		4 GLY A  16
THR A  15
VAL A 154
HIS A 157
 None
 1.05A 5ewuA-3lydA:
undetectable		 5ewuA-3lydA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0z PUTATIVE ALDOLASE

(Klebsiella
pneumoniae) 		PF07071
(KDGP_aldolase) 		4 GLY A  98
THR A  97
SER A  77
VAL A  95
 None
 1.05A 5ewuA-3m0zA:
undetectable		 5ewuA-3m0zA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgw LYSOZYME G

(Salmo salar) 		PF01464
(SLT) 		4 GLY A  15
THR A  13
SER A  34
VAL A  31
 None
 0.86A 5ewuA-3mgwA:
undetectable		 5ewuA-3mgwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwy URIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		4 GLY A 155
THR A 126
SER A 108
VAL A 105
 None
 0.68A 5ewuA-3nwyA:
undetectable		 5ewuA-3nwyA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE

(Aliivibrio
fischeri) 		PF07071
(KDGP_aldolase) 		4 GLY A  98
THR A  97
SER A  77
VAL A  95
 None
 1.04A 5ewuA-3nzrA:
undetectable		 5ewuA-3nzrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY A  69
SER A   7
VAL A  70
HIS A  46
 None
 1.10A 5ewuA-3o21A:
2.9		 5ewuA-3o21A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk1 INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens) 		PF00452
(Bcl-2) 		4 GLY A 217
SER A 269
VAL A 265
HIS A 224
 None
None
None
CD  A   5 (-3.5A)
 1.03A 5ewuA-3pk1A:
undetectable		 5ewuA-3pk1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		4 GLY A  91
THR A  92
VAL A  64
HIS A  24
 None
KCX  A 154 ( 4.4A)
None
ZN  A 333 ( 3.3A)
 1.00A 5ewuA-3pnzA:
undetectable		 5ewuA-3pnzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rof LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE PTPA

(Staphylococcus
aureus) 		PF01451
(LMWPc) 		4 GLY A  40
THR A  41
SER A  15
VAL A   7
 None
 0.99A 5ewuA-3rofA:
undetectable		 5ewuA-3rofA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4k PUTATIVE ESTERASE
RV1847/MT1895

(Mycobacterium
tuberculosis) 		PF03061
(4HBT) 		4 GLY A  48
THR A  47
SER A  94
VAL A  49
 None
 1.08A 5ewuA-3s4kA:
undetectable		 5ewuA-3s4kA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th1 CHLOROCATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A 128
SER A 124
VAL A 162
HIS A  97
 None
 1.15A 5ewuA-3th1A:
undetectable		 5ewuA-3th1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4d AMINOACRYLATE
PERACID REDUCTASE
RUTC

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 GLY A  21
THR A  22
SER A  31
VAL A  19
 None
 1.12A 5ewuA-3v4dA:
undetectable		 5ewuA-3v4dA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		4 GLY A 120
THR A 121
VAL A 115
HIS A 175
 None
 1.15A 5ewuA-3vmwA:
undetectable		 5ewuA-3vmwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnp HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00132
(Hexapep) 		4 GLY A  26
THR A  25
VAL A  28
HIS A  64
 None
None
None
MG  A 202 (-3.4A)
 0.99A 5ewuA-3vnpA:
undetectable		 5ewuA-3vnpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		4 GLY A 195
THR A 196
SER A 181
VAL A 177
 None
SQS  A 401 ( 4.3A)
None
SQS  A 401 ( 4.5A)
 0.87A 5ewuA-3vzbA:
undetectable		 5ewuA-3vzbA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 TRP A 310
GLY A 308
THR A 307
SER A 275
 None
 1.01A 5ewuA-3w4rA:
1.9		 5ewuA-3w4rA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311

(Methanocaldococcus
jannaschii) 		PF01261
(AP_endonuc_2) 		4 GLY A 157
THR A 190
VAL A 115
HIS A  78
 None
None
None
MN  A1002 (-3.6A)
 0.94A 5ewuA-3wqoA:
undetectable		 5ewuA-3wqoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus) 		PF01464
(SLT) 		4 GLY A  15
THR A  13
SER A  34
VAL A  31
 None
 0.92A 5ewuA-3wyhA:
undetectable		 5ewuA-3wyhA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze6 PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY A  20
THR A  19
VAL A  23
HIS A  46
 FSX  A 287 ( 3.6A)
None
None
SBY  A1285 (-3.5A)
 1.02A 5ewuA-3ze6A:
undetectable		 5ewuA-3ze6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		4 GLY A 196
THR A 195
SER A 200
VAL A 201
 None
 1.15A 5ewuA-4aahA:
undetectable		 5ewuA-4aahA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 TRP A  68
GLY A  51
THR A  17
SER A  63
VAL A  52
 None
None
5FX  A1531 ( 4.8A)
None
None
 1.37A 5ewuA-4bc5A:
undetectable		 5ewuA-4bc5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 TRP A 547
GLY A 803
THR A 802
VAL A 787
 None
 0.92A 5ewuA-4ci8A:
undetectable		 5ewuA-4ci8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrv PUTATIVE LIPOPROTEIN
GNA1162

(Neisseria
meningitidis) 		PF05643
(DUF799) 		4 GLY A  52
THR A  53
SER A  47
VAL A 114
 None
 1.11A 5ewuA-4hrvA:
undetectable		 5ewuA-4hrvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT

(Enterococcus
faecalis) 		PF02518
(HATPase_c) 		4 GLY A 121
SER A 123
VAL A 124
HIS A 101
 None
 1.01A 5ewuA-4hz5A:
undetectable		 5ewuA-4hz5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A3367
THR A3290
SER A3282
VAL A3280
HIS A3364
 None
 1.44A 5ewuA-4kc5A:
undetectable		 5ewuA-4kc5A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT

(Desulfomicrobium
baculatum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY S  20
THR S  19
VAL S  23
HIS S  46
 SF4  S 303 ( 3.8A)
None
None
None
 1.06A 5ewuA-4ko2S:
undetectable		 5ewuA-4ko2S:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrq PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Vibrio cholerae) 		PF01451
(LMWPc) 		4 GLY A  39
THR A  40
SER A  15
VAL A   7
 None
 0.94A 5ewuA-4lrqA:
undetectable		 5ewuA-4lrqA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjt MONALYSIN
MONALYSIN

(Pseudomonas
entomophila;
Pseudomonas
entomophila) 		no annotation
no annotation 		4 TRP A  83
GLY A  84
THR A  85
SER J  14
 None
 1.11A 5ewuA-4mjtA:
undetectable		 5ewuA-4mjtA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nql AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		4 GLY A 390
THR A 393
VAL A 410
HIS A 356
 None
None
None
ZN  A 501 (-3.4A)
 1.05A 5ewuA-4nqlA:
undetectable		 5ewuA-4nqlA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwh ABC TRANSPORTER

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLY A 187
THR A 144
SER A 190
VAL A 148
 None
 1.14A 5ewuA-4wwhA:
undetectable		 5ewuA-4wwhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd5 AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		4 GLY A 390
THR A 393
VAL A 410
HIS A 356
 None
None
None
ZN  A 502 (-3.2A)
 1.03A 5ewuA-4zd5A:
undetectable		 5ewuA-4zd5A:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 TRP A 985
GLY A 986
SER A1039
VAL A1041
HIS A1174
 None
 0.61A 5ewuA-4zhjA:
59.7		 5ewuA-4zhjA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 TRP A 985
GLY A 986
THR A 987
SER A1039
HIS A1174
 None
 0.78A 5ewuA-4zhjA:
59.7		 5ewuA-4zhjA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqn BOTULINUM NEUROTOXIN
TYPE D,BOTULINUM
NEUROTOXIN TYPE D

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 GLY A 274
SER A 359
VAL A 361
HIS A 229
 None
 1.12A 5ewuA-5bqnA:
undetectable		 5ewuA-5bqnA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF02514
(CobN-Mg_chel) 		6 TRP A1033
GLY A1034
THR A1035
SER A1087
VAL A1089
HIS A1223
 None
BEZ  A1401 (-3.6A)
BEZ  A1401 (-2.6A)
BEZ  A1401 (-2.5A)
BEZ  A1401 (-4.0A)
BEZ  A1401 (-3.5A)
 0.00A 5ewuA-5ewuA:
68.6		 5ewuA-5ewuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		4 GLY B 230
SER B 187
VAL B 188
HIS B  83
 PLP  B 501 (-4.0A)
PLP  B 501 (-2.7A)
None
PLP  B 501 (-4.0A)
 1.12A 5ewuA-5ey5B:
2.4		 5ewuA-5ey5B:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 GLY A 530
SER A 524
VAL A 232
HIS A 551
 None
 1.14A 5ewuA-5f7cA:
undetectable		 5ewuA-5f7cA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H 239
THR H 241
SER H 186
VAL H 189
 None
 1.05A 5ewuA-5iltH:
undetectable		 5ewuA-5iltH:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5p DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 GLY A 123
SER A 125
VAL A 126
HIS A 103
 ANP  A 501 (-3.4A)
NA  A 502 (-3.0A)
None
None
 1.02A 5ewuA-5j5pA:
undetectable		 5ewuA-5j5pA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 GLY A 252
SER A 205
VAL A 215
HIS A 192
 None
 0.83A 5ewuA-5jowA:
undetectable		 5ewuA-5jowA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens) 		PF00452
(Bcl-2) 		4 GLY A 217
SER A 269
VAL A 265
HIS A 224
 None
 0.98A 5ewuA-5jsbA:
undetectable		 5ewuA-5jsbA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY A  20
THR A  19
VAL A  23
HIS A  46
 SF4  A 303 ( 3.9A)
None
None
None
 1.04A 5ewuA-5jsyA:
undetectable		 5ewuA-5jsyA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 GLY A 186
THR A 187
SER A 200
VAL A 185
 None
 1.06A 5ewuA-5l56A:
undetectable		 5ewuA-5l56A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 4 GLY A  51
THR A 273
SER A  53
VAL A  54
 None
 1.13A 5ewuA-5nvaA:
undetectable		 5ewuA-5nvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7b PUTATIVE LOW
MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE SLR0328

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY A  40
THR A  41
SER A  14
VAL A   6
 None
 1.00A 5ewuA-5o7bA:
undetectable		 5ewuA-5o7bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN

(Homo sapiens) 		no annotation 4 GLY L 156
THR L 157
SER L 194
HIS L 192
 None
 0.99A 5ewuA-5ocyL:
undetectable		 5ewuA-5ocyL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 GLY B 153
THR B 154
SER B 191
HIS B 189
 None
 0.98A 5ewuA-5odbB:
undetectable		 5ewuA-5odbB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szq PROTOCADHERIN
GAMMA-A4

(Mus musculus) 		PF00028
(Cadherin) 		4 GLY A 484
THR A 483
SER A 445
VAL A 485
 None
None
MAN  A 706 ( 2.7A)
None
 1.06A 5ewuA-5szqA:
undetectable		 5ewuA-5szqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		4 GLY A 208
THR A 211
SER A 173
VAL A 207
 None
 1.14A 5ewuA-5tr1A:
undetectable		 5ewuA-5tr1A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		4 GLY A 444
SER A  23
VAL A  25
HIS A 453
 None
 1.07A 5ewuA-5upyA:
undetectable		 5ewuA-5upyA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 TRP A 466
THR A 374
VAL A 242
HIS A 193
 None
 0.96A 5ewuA-5w21A:
undetectable		 5ewuA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A  16
THR A  19
SER A  88
VAL A  15
 None
 1.10A 5ewuA-5w4xA:
2.9		 5ewuA-5w4xA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrp PYRUVATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A 311
SER A 314
VAL A 315
HIS A  38
 None
 1.09A 5ewuA-5wrpA:
undetectable		 5ewuA-5wrpA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 4 TRP A 571
GLY A 588
THR A 469
VAL A 467
 PQQ  A 701 (-4.6A)
None
None
None
 1.11A 5ewuA-5xm3A:
undetectable		 5ewuA-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 GLY A 198
SER A 250
VAL A 246
HIS A 205
 None
None
None
6AK  A 401 ( 4.4A)
 0.99A 5ewuA-6dm8A:
undetectable		 5ewuA-6dm8A:
undetectable