SIMILAR PATTERNS OF AMINO ACIDS FOR 5EWJ_B_QELB503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0p SITE-SPECIFIC
RECOMBINASE XERD

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		5 TYR A  85
ALA A   6
GLN A  10
ILE A   8
PHE A  11
 None
 1.28A 5ewjA-1a0pA:
undetectable
5ewjB-1a0pA:
undetectable		 5ewjA-1a0pA:
20.87
5ewjB-1a0pA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 TYR A 580
THR A 586
LEU A 582
PRO A 592
ILE A 591
 None
 1.27A 5ewjA-1aorA:
undetectable
5ewjB-1aorA:
undetectable		 5ewjA-1aorA:
21.86
5ewjB-1aorA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcz TRANSCARBOXYLASE
1.3S SUBUNIT

(Propionibacterium
freudenreichii) 		PF00364
(Biotin_lipoyl) 		5 THR A  75
LEU A  69
ALA A  96
ILE A 122
GLU A  93
 None
 1.49A 5ewjA-1dczA:
undetectable
5ewjB-1dczA:
undetectable		 5ewjA-1dczA:
14.40
5ewjB-1dczA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		5 LEU A 235
PRO A 212
ALA A 240
GLN A 244
ILE A 245
 None
NDP  A1277 (-4.1A)
None
None
None
 1.43A 5ewjA-1mxfA:
2.9
5ewjB-1mxfA:
4.0		 5ewjA-1mxfA:
21.90
5ewjB-1mxfA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 THR A 425
LEU A 559
ALA A 536
GLN A 422
ILE A 419
 None
 1.44A 5ewjA-1ofeA:
2.9
5ewjB-1ofeA:
3.0		 5ewjA-1ofeA:
12.85
5ewjB-1ofeA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn3 GLYCOSYLTRANSFERASE
GTFA

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 THR A 365
LEU A 332
ALA A 302
GLN A 309
ILE A 307
 None
 1.18A 5ewjA-1pn3A:
4.3
5ewjB-1pn3A:
2.0		 5ewjA-1pn3A:
19.91
5ewjB-1pn3A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Pyrococcus
furiosus) 		PF00290
(Trp_syntA) 		5 THR A  12
LEU A  22
PRO A  40
ALA A  68
ILE A  39
 None
 1.25A 5ewjA-1wdwA:
2.1
5ewjB-1wdwA:
undetectable		 5ewjA-1wdwA:
21.27
5ewjB-1wdwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		5 THR A 664
PRO A 666
ALA A 626
ILE A 667
GLU A 700
 None
 1.48A 5ewjA-1xf1A:
4.8
5ewjB-1xf1A:
2.7		 5ewjA-1xf1A:
16.85
5ewjB-1xf1A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		5 TYR 1 280
LEU 1 275
PRO 1 293
ALA 1 286
ILE 1 285
 None
 1.08A 5ewjA-1y791:
2.5
5ewjB-1y791:
undetectable		 5ewjA-1y791:
21.14
5ewjB-1y791:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4

(Viscum album) 		PF00161
(RIP) 		5 LEU A 233
ALA A 161
ILE A  21
PHE A  18
PRO A  38
 None
 1.29A 5ewjA-1yf8A:
undetectable
5ewjB-1yf8A:
undetectable		 5ewjA-1yf8A:
20.56
5ewjB-1yf8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389

(Mycobacterium
tuberculosis) 		PF13523
(Acetyltransf_8) 		5 ARG A  33
ALA A  48
GLN A  49
ILE A  95
GLU A  87
 None
 1.26A 5ewjA-1yk3A:
undetectable
5ewjB-1yk3A:
undetectable		 5ewjA-1yk3A:
19.69
5ewjB-1yk3A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		5 TYR A 152
LEU A  63
ALA A  17
ILE A 156
PHE A 155
 None
 1.50A 5ewjA-1yp4A:
undetectable
5ewjB-1yp4A:
undetectable		 5ewjA-1yp4A:
20.34
5ewjB-1yp4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE

(Yersinia
enterocolitica) 		PF00102
(Y_phosphatase) 		5 TYR A 248
THR A 238
LEU A 244
ALA A 258
ILE A 249
 None
 1.12A 5ewjA-1ytsA:
3.1
5ewjB-1ytsA:
2.0		 5ewjA-1ytsA:
20.83
5ewjB-1ytsA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		5 TYR A  39
THR A  37
LEU A 106
PRO A  43
ILE A  42
 None
 1.36A 5ewjA-1ztvA:
undetectable
5ewjB-1ztvA:
undetectable		 5ewjA-1ztvA:
21.21
5ewjB-1ztvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2him L-ASPARAGINASE 1

(Escherichia
coli) 		PF00710
(Asparaginase) 		5 THR A 307
ARG A 331
LEU A 330
GLN A 315
ILE A 207
 None
 1.45A 5ewjA-2himA:
3.9
5ewjB-2himA:
3.5		 5ewjA-2himA:
22.88
5ewjB-2himA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 ARG A1262
GLN A 870
PHE A 880
PRO A 842
GLU A 849
 None
 1.29A 5ewjA-3av6A:
undetectable
5ewjB-3av6A:
2.1		 5ewjA-3av6A:
14.62
5ewjB-3av6A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		5 THR A  89
LEU A 149
ALA A 376
ILE A  42
GLU A 254
 None
 1.25A 5ewjA-3clwA:
undetectable
5ewjB-3clwA:
undetectable		 5ewjA-3clwA:
23.60
5ewjB-3clwA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		5 THR A  14
ALA A 190
ILE A 192
PHE A 211
GLU A 185
 None
 1.50A 5ewjA-3e96A:
2.1
5ewjB-3e96A:
undetectable		 5ewjA-3e96A:
19.71
5ewjB-3e96A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		5 THR A 124
PRO A 117
ALA A 147
PHE A 141
GLU A  60
 None
 1.04A 5ewjA-3k9dA:
3.0
5ewjB-3k9dA:
4.2		 5ewjA-3k9dA:
21.28
5ewjB-3k9dA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		5 THR A  86
PRO A  89
ALA A 139
ILE A 140
PRO A 120
 None
 1.26A 5ewjA-3lezA:
undetectable
5ewjB-3lezA:
undetectable		 5ewjA-3lezA:
22.44
5ewjB-3lezA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 323
PRO A 167
ALA A 173
ILE A 171
GLU A 186
 None
 1.37A 5ewjA-3n6rA:
3.4
5ewjB-3n6rA:
2.1		 5ewjA-3n6rA:
20.21
5ewjB-3n6rA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		5 THR A 208
LEU A 312
PRO A  65
ALA A 100
GLU A 333
 None
 1.32A 5ewjA-3ntxA:
2.3
5ewjB-3ntxA:
3.4		 5ewjA-3ntxA:
22.22
5ewjB-3ntxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7v VOLTAGE-SENSOR
CONTAINING
PHOSPHATASE

(Ciona
intestinalis) 		PF00520
(Ion_trans) 		5 TYR S 150
ARG S 223
LEU S 137
GLN S 147
PHE S 149
 None
 1.10A 5ewjA-4g7vS:
undetectable
5ewjB-4g7vS:
undetectable		 5ewjA-4g7vS:
18.56
5ewjB-4g7vS:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im9 DNA PRIMASE

(Vibrio cholerae) 		PF08278
(DnaG_DnaB_bind) 		5 TYR A  27
LEU A  97
ALA A  19
GLN A  23
ILE A  22
 None
 1.39A 5ewjA-4im9A:
undetectable
5ewjB-4im9A:
undetectable		 5ewjA-4im9A:
16.36
5ewjB-4im9A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 279
GLN A 282
ILE A 283
PHE A 286
PRO A  99
 None
 1.03A 5ewjA-4nfyA:
6.0
5ewjB-4nfyA:
6.5		 5ewjA-4nfyA:
22.41
5ewjB-4nfyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		5 TYR A 190
THR A 163
PRO A 239
ALA A 170
ILE A 187
 None
 1.11A 5ewjA-4ookA:
undetectable
5ewjB-4ookA:
undetectable		 5ewjA-4ookA:
19.80
5ewjB-4ookA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		7 PRO B  78
ALA B 107
GLN B 110
ILE B 111
PHE B 114
PRO B 177
GLU B 236
 None
QEL  B 920 ( 3.9A)
QEL  B 920 (-3.0A)
QEL  B 920 (-4.6A)
QEL  B 920 (-3.6A)
QEL  B 920 (-4.6A)
QEL  B 920 (-2.9A)
 0.35A 5ewjA-4pe5B:
18.7
5ewjB-4pe5B:
36.1		 5ewjA-4pe5B:
18.60
5ewjB-4pe5B:
99.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LEU A 214
PRO A 184
ALA A 182
ILE A 187
GLU A 145
 None
 1.31A 5ewjA-4rewA:
undetectable
5ewjB-4rewA:
undetectable		 5ewjA-4rewA:
21.94
5ewjB-4rewA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rho UNCHARACTERIZED
PROTEIN

(Burkholderia
pseudomallei) 		PF15579
(Imm52) 		5 LEU A 173
ALA A 150
ILE A   3
PHE A 116
PRO A 165
 None
 1.32A 5ewjA-4rhoA:
undetectable
5ewjB-4rhoA:
undetectable		 5ewjA-4rhoA:
21.37
5ewjB-4rhoA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tll RECEPTOR SUBUNIT
GLUN2B

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		7 PRO B  73
ALA B 102
GLN B 105
ILE B 106
PHE B 109
PRO B 172
GLU B 231
 None
QEM  B 901 ( 4.0A)
QEM  B 901 (-3.3A)
QEM  B 901 (-4.6A)
QEM  B 901 (-4.4A)
QEM  B 901 (-4.5A)
QEM  B 901 (-3.1A)
 0.55A 5ewjA-4tllB:
30.5
5ewjB-4tllB:
49.3		 5ewjA-4tllB:
19.51
5ewjB-4tllB:
38.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		5 PRO A 104
ALA A 193
GLN A 197
ILE A 198
PHE A 201
 None
 1.46A 5ewjA-4x5sA:
undetectable
5ewjB-4x5sA:
undetectable		 5ewjA-4x5sA:
19.22
5ewjB-4x5sA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 LEU A  59
ALA A  63
ILE A  79
PHE A  92
GLU A  11
 None
 1.32A 5ewjA-4z3yA:
undetectable
5ewjB-4z3yA:
undetectable		 5ewjA-4z3yA:
18.76
5ewjB-4z3yA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 THR A 316
PRO A 202
ALA A 327
ILE A 200
PRO A 128
 None
 1.49A 5ewjA-5bwdA:
undetectable
5ewjB-5bwdA:
undetectable		 5ewjA-5bwdA:
19.09
5ewjB-5bwdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		5 THR A 327
LEU A 437
PRO A 326
ALA A 330
PHE A 393
 HEM  A 501 (-4.6A)
None
None
None
HEM  A 501 (-4.5A)
 1.35A 5ewjA-5e78A:
undetectable
5ewjB-5e78A:
undetectable		 5ewjA-5e78A:
22.42
5ewjB-5e78A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Pyrobaculum
calidifontis) 		PF13685
(Fe-ADH_2) 		5 THR A 103
LEU A 144
PRO A 102
ILE A 110
GLU A 208
 None
 1.49A 5ewjA-5fb3A:
2.5
5ewjB-5fb3A:
4.3		 5ewjA-5fb3A:
21.82
5ewjB-5fb3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyy S-RECEPTOR KINASE
SRK9

(Brassica rapa) 		PF00954
(S_locus_glycop)
PF01453
(B_lectin)
PF08276
(PAN_2) 		5 ARG A 337
ILE A 371
PHE A 357
PRO A 187
GLU A 211
 None
 1.46A 5ewjA-5gyyA:
2.1
5ewjB-5gyyA:
undetectable		 5ewjA-5gyyA:
20.32
5ewjB-5gyyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		5 THR A 203
PRO A 196
ALA A 226
PHE A 220
GLU A 142
 None
1VU  A 601 (-4.6A)
None
None
None
 1.12A 5ewjA-5jfmA:
undetectable
5ewjB-5jfmA:
3.8		 5ewjA-5jfmA:
22.74
5ewjB-5jfmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 5 TYR A  43
THR A  37
ALA A 104
ILE A 108
GLU A  47
 None
 1.20A 5ewjA-5olcA:
2.2
5ewjB-5olcA:
2.0		 5ewjA-5olcA:
13.07
5ewjB-5olcA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 THR A 463
PRO A 447
ILE A 446
PHE A 445
PRO A 637
 None
 1.41A 5ewjA-5opjA:
undetectable
5ewjB-5opjA:
undetectable		 5ewjA-5opjA:
12.50
5ewjB-5opjA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thk PUTATIVE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 ARG A 180
ALA A 131
ILE A 128
PHE A 125
GLU A 136
 None
 1.37A 5ewjA-5thkA:
6.5
5ewjB-5thkA:
2.9		 5ewjA-5thkA:
21.30
5ewjB-5thkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		6 PRO D  78
ALA D 107
GLN D 110
PHE D 114
PRO D 177
GLU D 236
 None
 0.42A 5ewjA-5tpzD:
28.6
5ewjB-5tpzD:
51.7		 5ewjA-5tpzD:
24.88
5ewjB-5tpzD:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 ARG A 468
ALA A 304
ILE A  55
PRO A 350
GLU A 517
 None
 1.23A 5ewjA-5u3cA:
4.3
5ewjB-5u3cA:
2.1		 5ewjA-5u3cA:
22.60
5ewjB-5u3cA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 ALA B 100
ILE B 104
PHE B 107
PRO B 170
GLU B 227
 None
 0.80A 5ewjA-5up2B:
25.1
5ewjB-5up2B:
37.2		 5ewjA-5up2B:
18.85
5ewjB-5up2B:
49.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA

(Escherichia
virus T4;
Mycobacterium
kansasii) 		PF00959
(Phage_lysozyme)
PF14011
(ESX-1_EspG) 		5 TYR A 189
THR A 190
LEU A 223
ALA A 168
GLU A 201
 None
 1.30A 5ewjA-5vbaA:
undetectable
5ewjB-5vbaA:
undetectable		 5ewjA-5vbaA:
21.68
5ewjB-5vbaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		5 TYR A 593
THR A 594
ARG A 607
LEU A 135
ALA A 138
 None
None
SO4  A 712 (-2.8A)
None
None
 1.26A 5ewjA-5wgxA:
3.8
5ewjB-5wgxA:
undetectable		 5ewjA-5wgxA:
19.41
5ewjB-5wgxA:
20.39