SIMILAR PATTERNS OF AMINO ACIDS FOR 5EVY_X_SALX502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Galdieria
partita) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 SER A  61
MET A 309
LEU A 135
PHE A  40
 None
 1.28A 5evyX-1iwaA:
0.0		 5evyX-1iwaA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxm DNA POLYMERASE
SLIDING CLAMP

(Archaeoglobus
fulgidus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 SER A 156
MET A 133
LEU A 181
PHE A 184
 None
 1.21A 5evyX-1rxmA:
0.0		 5evyX-1rxmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 SER B 108
GLN B  80
LEU B 132
PHE B  95
 None
 1.44A 5evyX-1tnuB:
undetectable		 5evyX-1tnuB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f73 FATTY ACID-BINDING
PROTEIN, LIVER

(Homo sapiens) 		PF14651
(Lipocalin_7) 		4 SER A   0
GLN A  43
LEU A  91
PHE A   3
 None
 1.35A 5evyX-2f73A:
undetectable		 5evyX-2f73A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 SER A 488
GLN A 308
LEU A 242
PHE A 304
 None
 1.41A 5evyX-2gmhA:
18.2		 5evyX-2gmhA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l48 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Bacillus phage
Gamma) 		PF12123
(Amidase02_C) 		4 SER A 172
MET A 192
LEU A 187
PHE A 196
 None
 1.40A 5evyX-2l48A:
undetectable		 5evyX-2l48A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 SER A 121
MET A 265
LEU A 225
PHE A 267
 None
 1.31A 5evyX-2olsA:
0.0		 5evyX-2olsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8w ACETOACETATE
DECARBOXYLASE ADC

(Legionella
pneumophila) 		PF06314
(ADC) 		4 SER A 105
GLN A  89
LEU A 215
PHE A  70
 None
 1.33A 5evyX-3c8wA:
0.0		 5evyX-3c8wA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hde LYSOZYME

(Escherichia
virus Lambda) 		PF00959
(Phage_lysozyme) 		4 SER A 117
MET A  98
LEU A 102
PHE A 105
 None
 1.47A 5evyX-3hdeA:
undetectable		 5evyX-3hdeA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm2 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE

(Corynebacterium
diphtheriae) 		no annotation 4 GLN A 139
MET A 132
LEU A 136
PHE A 140
 None
 1.27A 5evyX-3hm2A:
2.2		 5evyX-3hm2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 SER A 437
GLN A 417
LEU A 415
PHE A 420
 None
 1.39A 5evyX-3hpaA:
undetectable		 5evyX-3hpaA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5q NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		no annotation 4 SER B1437
MET B1448
LEU B1430
PHE B1444
 None
 1.28A 5evyX-3i5qB:
undetectable		 5evyX-3i5qB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		4 SER A 286
GLN A 283
LEU A 266
PHE A 573
 None
 1.27A 5evyX-3nheA:
undetectable		 5evyX-3nheA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 SER M 105
MET M 150
LEU M 153
PHE M 116
 None
 1.28A 5evyX-3rkoM:
1.1		 5evyX-3rkoM:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 SER A 733
GLN A 414
LEU A 708
PHE A 416
 None
 1.44A 5evyX-4cvuA:
undetectable		 5evyX-4cvuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 SER A 190
MET A 223
LEU A 207
PHE A 245
 None
 1.31A 5evyX-4eqvA:
undetectable		 5evyX-4eqvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr9 PROBABLE TRNA
SULFURTRANSFERASE

(Thermotoga
maritima) 		PF02568
(ThiI)
PF02926
(THUMP) 		4 SER A 208
GLN A 247
LEU A 248
PHE A 347
 None
 1.48A 5evyX-4kr9A:
undetectable		 5evyX-4kr9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 GLN A 958
MET A1011
LEU A 990
PHE A 964
 None
 1.49A 5evyX-4lnvA:
undetectable		 5evyX-4lnvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 SER A  61
MET A 309
LEU A 135
PHE A  40
 None
 1.25A 5evyX-4mkvA:
undetectable		 5evyX-4mkvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 SER A 161
MET A 144
LEU A  93
PHE A 140
 55X  A 201 (-3.8A)
None
None
None
 1.27A 5evyX-5cw8A:
undetectable		 5evyX-5cw8A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		4 SER A 195
GLN A 131
LEU A 124
PHE A 132
 None
 1.25A 5evyX-5lc8A:
undetectable		 5evyX-5lc8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		4 SER A  37
MET A  92
LEU A  91
PHE A  59
 None
 1.23A 5evyX-5lmcA:
3.1		 5evyX-5lmcA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 4 SER A 332
GLN A 336
LEU A 366
PHE A  75
 None
 1.29A 5evyX-5xgvA:
25.9		 5evyX-5xgvA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 SER 2 286
MET 2 250
LEU 2 254
PHE 2 370
 None
 1.01A 5evyX-5zvs2:
undetectable		 5evyX-5zvs2:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 4 SER A 865
MET A 656
LEU A 812
PHE A 658
 None
 1.29A 5evyX-6cnhA:
undetectable		 5evyX-6cnhA:
10.92