SIMILAR PATTERNS OF AMINO ACIDS FOR 5EUM_B_ACTB603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezi CMP-N-ACETYLNEURAMIN
IC ACID SYNTHETASE

(Neisseria
meningitidis) 		PF02348
(CTP_transf_3) 		4 ALA A 177
ASN A 175
ARG A 110
ILE A 178
 None
 1.36A 5eumB-1eziA:
0.4		 5eumB-1eziA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		4 ALA A 205
ASN A 201
ARG A 315
ILE A 206
 None
 1.43A 5eumB-1pm2A:
0.0		 5eumB-1pm2A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkg MAJOR MITE FECAL
ALLERGEN DER P 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		4 ALA A 204
ASN A 203
ARG A 208
ILE A 207
 None
 1.31A 5eumB-1xkgA:
0.0		 5eumB-1xkgA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 ALA A 325
ASN A 280
ARG A 315
ILE A 314
 None
 1.17A 5eumB-2cvtA:
0.8		 5eumB-2cvtA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN

(Homo sapiens) 		PF00782
(DSPc) 		4 ALA A 122
ASN A 121
ARG A  26
ILE A 124
 SO4  A   1 (-3.6A)
None
None
SO4  A   1 (-4.1A)
 1.21A 5eumB-2r0bA:
0.0		 5eumB-2r0bA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 ALA B 619
ASN B 711
ARG B 626
ILE B 620
 None
 1.30A 5eumB-3iz3B:
0.0		 5eumB-3iz3B:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 ALA A 400
ASN A 401
ARG A 425
ILE A 429
 None
 0.98A 5eumB-3prlA:
0.2		 5eumB-3prlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 ALA A 130
ASN A 134
ARG A 161
ILE A 125
 None
 1.02A 5eumB-3rreA:
1.7		 5eumB-3rreA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		4 ALA A 261
ASN A 260
ARG A 306
ILE A 332
 None
 1.02A 5eumB-3s9jA:
undetectable		 5eumB-3s9jA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfk PUTATIVE CYTOPLASMIC
PROTEIN

(Enterobacter
cloacae) 		PF14113
(Tae4) 		4 ALA A  45
ASN A  44
ARG A  49
ILE A  48
 None
 1.22A 5eumB-4hfkA:
undetectable		 5eumB-4hfkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr1 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi virus 1) 		no annotation 4 ALA B  50
ASN B  54
ARG B  16
ILE B  12
 None
 0.96A 5eumB-4hr1B:
undetectable		 5eumB-4hr1B:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1g NUCLEOCAPSID

(Leanyer virus) 		PF00952
(Bunya_nucleocap) 		4 ALA A  92
ASN A  91
ARG A  97
ILE A  93
 None
None
U  E   3 ( 4.0A)
None
 1.29A 5eumB-4j1gA:
undetectable		 5eumB-4j1gA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9z PUTATIVE
THIOL-DISULFIDE
OXIDOREDUCTASE

(Bacteroides
vulgatus) 		PF08534
(Redoxin) 		4 ALA A 140
ASN A 139
ARG A 127
ILE A 129
 None
 1.49A 5eumB-4k9zA:
undetectable		 5eumB-4k9zA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		4 ALA B 320
ASN B 317
ARG C 113
ILE C  76
 None
 1.48A 5eumB-5a8rB:
undetectable		 5eumB-5a8rB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		4 ALA A 316
ASN A 313
ARG A 279
ILE A 275
 ALA  A 316 ( 0.0A)
ASN  A 313 ( 0.6A)
ARG  A 279 ( 0.6A)
ILE  A 275 ( 0.7A)
 1.16A 5eumB-5ec3A:
undetectable		 5eumB-5ec3A:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		4 ALA A 439
ASN A 440
ARG A 452
ILE A 455
 None
 0.03A 5eumB-5eumA:
42.7		 5eumB-5eumA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA
METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT GAMMA

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		4 ALA B 320
ASN B 317
ARG C 113
ILE C  76
 None
 1.41A 5eumB-5n1qB:
0.6		 5eumB-5n1qB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		4 ALA B 321
ASN B 318
ARG C 113
ILE C  76
 None
 1.44A 5eumB-5n28B:
0.6		 5eumB-5n28B:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A  94
ASN A  95
ARG A 184
ILE A 180
 None
 1.22A 5eumB-6b5eA:
undetectable		 5eumB-6b5eA:
undetectable