SIMILAR PATTERNS OF AMINO ACIDS FOR 5EU8_B_010B6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geg ACETOIN REDUCTASE

(Klebsiella
pneumoniae) 		PF00106
(adh_short) 		4 ASN A 178
LEU A 247
THR A 163
CYH A 181
 None
 1.49A 5eu8A-1gegA:
0.0		 5eu8A-1gegA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ASN B 306
LEU B 279
HIS B 278
CYH B 280
 None
 1.20A 5eu8A-1mu2B:
0.0		 5eu8A-1mu2B:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		4 LEU A 238
HIS A 221
THR A 198
CYH A 219
 None
FE  A 401 (-3.2A)
None
None
 1.32A 5eu8A-1qfcA:
0.0		 5eu8A-1qfcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arz HYPOTHETICAL PROTEIN
PA4388

(Pseudomonas
aeruginosa) 		PF10615
(DUF2470)
PF13883
(Pyrid_oxidase_2) 		4 ASN A 153
LEU A  41
HIS A 201
CYH A  40
 None
 1.23A 5eu8A-2arzA:
2.5		 5eu8A-2arzA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		4 LEU X 236
HIS X 219
THR X 196
CYH X 217
 None
FE2  X1306 (-3.2A)
None
None
 1.43A 5eu8A-2bq8X:
0.0		 5eu8A-2bq8X:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC

(Mus musculus) 		PF01590
(GAF) 		4 ASN A 276
LEU A 257
THR A 253
CYH A 258
 None
 1.45A 5eu8A-2k31A:
0.0		 5eu8A-2k31A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASN A 312
LEU A  56
THR A 103
CYH A  57
 None
 1.42A 5eu8A-2q50A:
0.0		 5eu8A-2q50A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 508
HIS A 480
THR A 459
CYH A 506
 None
 1.49A 5eu8A-3b2dA:
0.0		 5eu8A-3b2dA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 ASN A 352
LEU A 355
HIS A 323
THR A 326
 None
 1.49A 5eu8A-3cihA:
undetectable		 5eu8A-3cihA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES1

(Plasmodium
falciparum) 		PF01015
(Ribosomal_S3Ae) 		4 ASN B  69
LEU B  70
HIS B  81
THR B 106
 None
 1.12A 5eu8A-3j7aB:
undetectable		 5eu8A-3j7aB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7x PROBABLE THIOL
PEROXIDASE

(Staphylococcus
aureus) 		PF08534
(Redoxin) 		4 ASN A  68
LEU A  98
THR A  80
CYH A  93
 None
 1.05A 5eu8A-3p7xA:
undetectable		 5eu8A-3p7xA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3

(Mus musculus) 		PF00995
(Sec1) 		4 ASN A 528
LEU A 188
THR A 231
CYH A 185
 None
 1.37A 5eu8A-3pukA:
undetectable		 5eu8A-3pukA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 ASN A 310
HIS A 675
THR A 661
CYH A  24
 None
SO4  A 803 (-3.8A)
None
None
 1.46A 5eu8A-3wiqA:
undetectable		 5eu8A-3wiqA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfy DIHYDROOROTASE

(Burkholderia
cenocepacia) 		PF01979
(Amidohydro_1) 		4 LEU A 240
HIS A 192
THR A 194
CYH A 239
 None
ZN  A 402 (-3.2A)
None
None
 1.46A 5eu8A-4lfyA:
undetectable		 5eu8A-4lfyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE

(Pectobacterium
atrosepticum) 		PF02275
(CBAH) 		4 ASN A  84
LEU A  86
THR A 279
CYH A   1
 None
 1.38A 5eu8A-4wl2A:
undetectable		 5eu8A-4wl2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvs DONOR 45 01DG5 COREE
GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 ASN G 386
LEU G 416
HIS G 374
CYH G 331
 NAG  G 607 (-1.8A)
None
None
None
 1.24A 5eu8A-4xvsG:
undetectable		 5eu8A-4xvsG:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zro 3C-LIKE PROTEINASE

(Alphacoronavirus
1) 		PF05409
(Peptidase_C30) 		4 ASN A  25
LEU A  27
THR A  47
CYH A 144
 None
 0.74A 5eu8A-4zroA:
43.1		 5eu8A-4zroA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buv PUTATIVE EPIMERASE

(Yersinia
enterocolitica) 		PF00908
(dTDP_sugar_isom) 		4 ASN A   9
LEU A   8
THR A  95
CYH A  13
 None
 1.39A 5eu8A-5buvA:
undetectable		 5eu8A-5buvA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eog PROTEIN MAB-21-LIKE
1

(Homo sapiens) 		PF03281
(Mab-21) 		4 LEU A 307
HIS A 273
THR A 276
CYH A 310
 None
 1.05A 5eu8A-5eogA:
undetectable		 5eu8A-5eogA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 4 ASN B 468
LEU B 467
HIS B 429
THR B 470
 NAG  B 608 (-1.9A)
None
None
None
 1.50A 5eu8A-5fbhB:
0.6		 5eu8A-5fbhB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu5 CBM77-RFPL

(Ruminococcus
flavefaciens) 		no annotation 4 ASN A1087
LEU A1088
THR A1112
CYH A1105
 None
 1.26A 5eu8A-5fu5A:
undetectable		 5eu8A-5fu5A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 ASN A 183
LEU A 192
HIS A 190
THR A 188
 None
 1.34A 5eu8A-5oc1A:
undetectable		 5eu8A-5oc1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		4 LEU A 238
HIS A 221
THR A 198
CYH A 219
 None
FE  A 403 (-3.3A)
None
None
 1.43A 5eu8A-5uq6A:
undetectable		 5eu8A-5uq6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgm DIHYDROOROTASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		4 LEU A 218
HIS A 173
THR A 175
CYH A 217
 None
ZN  A 401 (-3.3A)
None
None
 1.49A 5eu8A-5vgmA:
undetectable		 5eu8A-5vgmA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L14,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00238
(Ribosomal_L14) 		4 ASN L   9
LEU L  19
HIS L   7
CYH L  21
 None
None
G  A1703 ( 4.1A)
None
 1.38A 5eu8A-5x8tL:
undetectable		 5eu8A-5x8tL:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 LEU 21106
HIS 21207
THR 21250
CYH 21105
 None
 1.37A 5eu8A-5zvs2:
undetectable		 5eu8A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 LEU A1127
HIS A1099
THR A1101
CYH A1135
 None
 1.28A 5eu8A-6f9nA:
undetectable		 5eu8A-6f9nA:
undetectable