SIMILAR PATTERNS OF AMINO ACIDS FOR 5ESL_A_1YNA701_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ALA A 693
TYR A 127
PRO A 324
GLY A 319
 None
ADP  A 998 (-4.4A)
None
None
 0.95A 5eslA-1br2A:
0.0		 5eslA-1br2A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		4 ALA A 541
PRO A 234
GLY A  73
LEU A 200
 None
None
HEM  A 800 ( 4.2A)
None
 1.00A 5eslA-1ehkA:
1.3		 5eslA-1ehkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		4 ALA A 312
PRO A 468
GLY A 185
LEU A 326
 None
 0.93A 5eslA-1f0iA:
undetectable		 5eslA-1f0iA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 ALA A 332
TYR A 335
GLY A 265
LEU A 284
 None
 0.89A 5eslA-1ileA:
0.0		 5eslA-1ileA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 450
PRO A 368
GLY A 334
LEU A 362
 None
 1.02A 5eslA-1k4qA:
0.0		 5eslA-1k4qA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 ALA A 233
TYR A  80
GLY A 339
LEU A   6
 None
 0.87A 5eslA-1mb9A:
0.3		 5eslA-1mb9A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		4 ALA A 116
PRO A 109
GLY A  22
LEU A  62
 None
 0.98A 5eslA-1n1aA:
undetectable		 5eslA-1n1aA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ALA A 217
TYR A 218
PRO A 408
GLY A 379
 None
 0.95A 5eslA-1obbA:
0.0		 5eslA-1obbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		4 ALA A  26
PRO A  11
GLY A 135
LEU A 116
 None
None
4TP  A 332 ( 4.0A)
None
 1.02A 5eslA-1ps6A:
undetectable		 5eslA-1ps6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1

(Rattus
norvegicus) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 ALA A 290
TYR A 295
PRO A 722
GLY A 664
 None
 1.01A 5eslA-1qasA:
undetectable		 5eslA-1qasA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		4 ALA A 239
TYR A 233
GLY A 148
LEU A  52
 None
 0.98A 5eslA-1smlA:
undetectable		 5eslA-1smlA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		4 ALA A 332
TYR A 335
GLY A 265
LEU A 284
 None
 0.87A 5eslA-1ue0A:
undetectable		 5eslA-1ue0A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 ALA A 146
PRO A 161
GLY A  41
LEU A 188
 None
None
SO4  A 245 (-3.3A)
None
 1.02A 5eslA-1vplA:
undetectable		 5eslA-1vplA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 ALA A 218
PRO A 295
GLY A 346
LEU A 341
 None
 0.84A 5eslA-1yiqA:
undetectable		 5eslA-1yiqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		4 TYR A 258
PRO A 168
GLY A 162
LEU A 242
 None
 1.00A 5eslA-1z6rA:
undetectable		 5eslA-1z6rA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		4 ALA A  28
PRO A 210
GLY A 169
LEU A 213
 None
 0.98A 5eslA-1z7aA:
undetectable		 5eslA-1z7aA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvh IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA A  61
TYR A  60
GLY A  26
LEU A  72
 None
 1.02A 5eslA-1zvhA:
undetectable		 5eslA-1zvhA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00266
(Aminotran_5) 		4 ALA A 250
PRO A  61
GLY A  68
LEU A 267
 None
None
PLP  A1201 (-3.6A)
None
 1.02A 5eslA-2bkwA:
undetectable		 5eslA-2bkwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		4 ALA A 528
TYR A 531
GLY A 261
LEU A 385
 None
 0.78A 5eslA-2f5uA:
undetectable		 5eslA-2f5uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ALA A  93
TYR A   3
PRO A  89
GLY A  51
 None
 0.99A 5eslA-2gcaA:
undetectable		 5eslA-2gcaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 ALA A 743
TYR A 742
GLY A 847
LEU A 617
 None
 0.74A 5eslA-2hg4A:
0.4		 5eslA-2hg4A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 ALA A 136
TYR A 135
GLY A  72
LEU A  81
 None
None
None
CSO  A  82 ( 4.4A)
 0.84A 5eslA-2nqaA:
undetectable		 5eslA-2nqaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT

(Mus musculus) 		PF05843
(Suf) 		4 ALA A 297
TYR A 300
GLY A 175
LEU A 271
 None
 0.88A 5eslA-2ooeA:
undetectable		 5eslA-2ooeA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR

(Caldanaerobacter
subterraneus) 		PF00079
(Serpin) 		4 ALA A  88
PRO A 413
GLY A 262
LEU A 292
 None
 1.00A 5eslA-2pefA:
undetectable		 5eslA-2pefA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		4 ALA B 205
PRO B 239
GLY B 511
LEU B 232
 None
 1.00A 5eslA-2pffB:
undetectable		 5eslA-2pffB:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ALA A 752
TYR A 751
GLY A 855
LEU A 626
 None
ACT  A 950 ( 4.5A)
None
None
 0.98A 5eslA-2qo3A:
0.7		 5eslA-2qo3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1v DJ-1

(Homo sapiens) 		PF01965
(DJ-1_PfpI) 		4 ALA A  14
PRO A  22
GLY A 174
LEU A 153
 None
 0.99A 5eslA-2r1vA:
undetectable		 5eslA-2r1vA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		4 ALA A 207
PRO A 215
GLY A 110
LEU A 222
 None
 0.97A 5eslA-2r7dA:
undetectable		 5eslA-2r7dA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 175
TYR A 178
GLY A  85
LEU A 205
 None
None
ANP  A1480 ( 3.8A)
ANP  A1480 ( 4.7A)
 0.99A 5eslA-2v55A:
undetectable		 5eslA-2v55A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhq NTPASE P4

(Pseudomonas
phage phi12) 		PF11602
(NTPase_P4) 		4 ALA A 154
TYR A 153
GLY A 132
LEU A 294
 None
 1.01A 5eslA-2vhqA:
undetectable		 5eslA-2vhqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		4 ALA A 367
TYR A 364
GLY A 228
LEU A 156
 None
 0.98A 5eslA-2vugA:
undetectable		 5eslA-2vugA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxb DNA REPAIR PROTEIN
RHP9

(Schizosaccharomyces
pombe) 		PF00533
(BRCT) 		4 ALA A 199
TYR A 202
GLY A  50
LEU A  60
 None
 0.95A 5eslA-2vxbA:
undetectable		 5eslA-2vxbA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE

(Rhodothermus
marinus) 		no annotation 4 ALA A 319
TYR A 322
GLY A 203
LEU A 240
 None
 0.93A 5eslA-2y4lA:
undetectable		 5eslA-2y4lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 ALA A  80
PRO A 341
GLY A  12
LEU A  57
 None
 0.82A 5eslA-2y9xA:
undetectable		 5eslA-2y9xA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 339
PRO A  80
GLY A 140
LEU A 121
 None
 1.00A 5eslA-2z1qA:
undetectable		 5eslA-2z1qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		4 ALA A 213
TYR A 216
GLY A 384
LEU A 465
 None
 1.01A 5eslA-2ze4A:
undetectable		 5eslA-2ze4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		4 ALA A 307
PRO A 462
GLY A 183
LEU A 321
 None
 0.94A 5eslA-2ze4A:
undetectable		 5eslA-2ze4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ALA A 159
TYR A 158
PRO A 200
GLY A 231
 None
 0.79A 5eslA-3aatA:
undetectable		 5eslA-3aatA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e29 UNCHARACTERIZED
PROTEIN Q7WE92_BORBR

(Bordetella
bronchiseptica) 		PF03061
(4HBT) 		4 ALA A 110
TYR A 131
GLY A 121
LEU A  61
 None
 1.00A 5eslA-3e29A:
undetectable		 5eslA-3e29A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go1 FAB 268-D, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA L 173
TYR L 172
PRO L  40
GLY L  99
 None
 0.90A 5eslA-3go1L:
undetectable		 5eslA-3go1L:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ALA B 357
PRO B 412
GLY B 295
LEU B 310
 None
 0.97A 5eslA-3h32B:
undetectable		 5eslA-3h32B:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		4 ALA A  45
TYR A  49
PRO A  78
GLY A 111
 None
 1.00A 5eslA-3hgoA:
undetectable		 5eslA-3hgoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 ALA A 366
TYR A 367
GLY A 265
LEU A 382
 None
 0.98A 5eslA-3ifsA:
1.0		 5eslA-3ifsA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ite SIDN SIDEROPHORE
SYNTHETASE

(Epichloe
festucae) 		PF00501
(AMP-binding) 		4 ALA A  25
TYR A  53
GLY A 349
LEU A 239
 None
 0.74A 5eslA-3iteA:
undetectable		 5eslA-3iteA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 277
PRO A 293
GLY A  88
LEU A 183
 None
None
None
NAD  A 503 (-3.7A)
 0.99A 5eslA-3jv7A:
undetectable		 5eslA-3jv7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		4 ALA A 130
TYR A 131
GLY A 112
LEU A   6
 None
 0.96A 5eslA-3l4eA:
undetectable		 5eslA-3l4eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngf AP ENDONUCLEASE,
FAMILY 2

(Brucella
abortus) 		PF01261
(AP_endonuc_2) 		4 ALA A 254
TYR A 256
PRO A 213
LEU A 223
 None
 0.97A 5eslA-3ngfA:
undetectable		 5eslA-3ngfA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 ALA A 170
PRO A 130
GLY A 146
LEU A 134
 None
None
None
NAD  A 400 (-4.0A)
 0.99A 5eslA-3qbdA:
undetectable		 5eslA-3qbdA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii) 		PF12146
(Hydrolase_4) 		4 ALA A 116
PRO A 131
GLY A 222
LEU A 217
 CL  A 292 ( 3.7A)
None
NA  A 280 (-4.0A)
NA  A 281 ( 4.3A)
 1.00A 5eslA-3qm1A:
undetectable		 5eslA-3qm1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
marinum) 		no annotation 4 ALA B  15
PRO B 217
GLY B 212
LEU B 193
 None
 0.95A 5eslA-3tzqB:
undetectable		 5eslA-3tzqB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		4 TYR A 191
PRO A 159
GLY A 221
LEU A 310
 None
 0.95A 5eslA-3ujpA:
undetectable		 5eslA-3ujpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13534
(Fer4_17) 		4 TYR B 146
PRO A  75
GLY A 420
LEU A 184
 None
None
FAD  A 702 (-3.6A)
None
 1.00A 5eslA-3vrbB:
undetectable		 5eslA-3vrbB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 ALA A 227
PRO A 133
GLY A 270
LEU A 254
 None
 1.01A 5eslA-3wibA:
undetectable		 5eslA-3wibA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ALA A 262
TYR A 282
GLY A 346
LEU A 273
 None
 0.92A 5eslA-3zyvA:
undetectable		 5eslA-3zyvA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 ALA A 100
TYR A  99
PRO A 221
GLY A 286
 None
 1.00A 5eslA-4a7kA:
undetectable		 5eslA-4a7kA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		4 ALA A 180
PRO A 184
GLY A 189
LEU A 347
 None
 0.90A 5eslA-4ddqA:
0.7		 5eslA-4ddqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 ALA A 373
PRO A 319
GLY A 145
LEU A 109
 None
 0.93A 5eslA-4dshA:
undetectable		 5eslA-4dshA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		4 TYR A 243
PRO A  93
GLY A  43
LEU A  58
 None
 0.97A 5eslA-4g76A:
undetectable		 5eslA-4g76A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ALA A 178
PRO A 174
GLY A 310
LEU A 234
 None
 0.97A 5eslA-4jzyA:
undetectable		 5eslA-4jzyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		4 ALA A 337
TYR A 334
PRO A 258
GLY A 492
 None
 1.01A 5eslA-4k90A:
undetectable		 5eslA-4k90A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		4 ALA A 220
TYR A 221
PRO A 303
LEU A 205
 None
 0.92A 5eslA-4mfiA:
undetectable		 5eslA-4mfiA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4op4 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Vibrio cholerae) 		PF01546
(Peptidase_M20) 		4 ALA A 248
PRO A 233
GLY A 218
LEU A 106
 None
None
BU1  A 307 ( 3.7A)
None
 0.97A 5eslA-4op4A:
undetectable		 5eslA-4op4A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 ALA A 203
PRO A 294
GLY A 160
LEU A 171
 None
 0.97A 5eslA-4qwwA:
undetectable		 5eslA-4qwwA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ALA A 346
PRO A 214
GLY A 219
LEU A 235
 None
 1.02A 5eslA-4rjkA:
undetectable		 5eslA-4rjkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		4 ALA A 140
TYR A 143
GLY A 173
LEU A 262
 None
 0.99A 5eslA-4udnA:
undetectable		 5eslA-4udnA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN
INTRAFLAGELLAR
TRANSPORT PROTEIN
IFT52

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6)
no annotation 		4 ALA A 410
PRO A 416
GLY A 325
LEU B 343
 None
FLC  A1647 (-3.5A)
None
None
 0.92A 5eslA-4uzyA:
undetectable		 5eslA-4uzyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 ALA A 158
TYR A 157
PRO A 199
GLY A 230
 None
 0.96A 5eslA-4wb0A:
undetectable		 5eslA-4wb0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yze HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR NEMR

(Escherichia
coli) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		4 ALA A 165
TYR A 164
GLY A  28
LEU A 107
 None
 0.94A 5eslA-4yzeA:
undetectable		 5eslA-4yzeA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 ALA A 135
PRO A 175
GLY A 356
LEU A 126
 None
 0.91A 5eslA-4zr0A:
undetectable		 5eslA-4zr0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8d CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43) 		4 ALA A  46
PRO A 167
GLY A 155
LEU A 194
 GOL  A1340 (-4.1A)
None
None
None
 0.98A 5eslA-5a8dA:
undetectable		 5eslA-5a8dA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		4 ALA A 103
TYR A  81
GLY A 445
LEU A 248
 None
 0.99A 5eslA-5djsA:
undetectable		 5eslA-5djsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 ALA B 479
PRO B 562
GLY B 669
LEU B 608
 None
 0.94A 5eslA-5dlqB:
undetectable		 5eslA-5dlqB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MINOR STRUCTURAL
PROTEIN 5

(Lactococcus
phage Tuc2009) 		no annotation 4 ALA B  10
TYR B  11
GLY B 256
LEU B 235
 None
 0.88A 5eslA-5e7tB:
undetectable		 5eslA-5e7tB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		4 ALA A 303
TYR A 304
PRO A  53
GLY A  73
 NA  A 401 ( 4.7A)
None
None
None
 0.95A 5eslA-5evjA:
0.7		 5eslA-5evjA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ALA A 634
TYR A 637
GLY A 543
LEU A 664
 None
None
None
4ZS  A 901 (-3.6A)
 1.02A 5eslA-5ezrA:
undetectable		 5eslA-5ezrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f89 CAP248-2B LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 ALA L 174
TYR L 173
PRO L  40
GLY L  99
 None
 0.99A 5eslA-5f89L:
undetectable		 5eslA-5f89L:
17.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 ALA A  61
TYR A  64
PRO A 230
GLY A 303
LEU A 376
 X2N  A 590 (-3.5A)
None
X2N  A 590 (-4.2A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.3A)
 0.52A 5eslA-5fsaA:
57.3		 5eslA-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ALA A 153
PRO A 174
GLY A 281
LEU A 232
 None
 0.89A 5eslA-5gmsA:
undetectable		 5eslA-5gmsA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		4 ALA A 146
PRO A 193
GLY A 180
LEU A 171
 None
 1.00A 5eslA-5gwnA:
undetectable		 5eslA-5gwnA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 ALA A  69
TYR A  72
PRO A 238
GLY A 310
LEU A 380
 None
None
None
VOR  A 602 (-4.3A)
VOR  A 602 (-4.0A)
 0.48A 5eslA-5hs1A:
63.1		 5eslA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 ALA A  70
TYR A  73
PRO A 239
GLY A 311
LEU A 381
 1YN  A 602 (-3.4A)
1YN  A 602 (-4.9A)
1YN  A 602 ( 4.8A)
1YN  A 602 (-3.9A)
1YN  A 602 ( 4.7A)
 0.29A 5eslA-5jlcA:
59.3		 5eslA-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku7 TIR-NB-LRR TYPE
RESISTANCE PROTEIN
RPV1

(Vitis
rotundifolia) 		PF01582
(TIR) 		4 ALA A 136
TYR A 138
GLY A 161
LEU A  98
 None
 0.81A 5eslA-5ku7A:
undetectable		 5eslA-5ku7A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m13 SYNTHETIC NANOBODY
L2_C06 (A-MBP#2)

(synthetic
construct) 		no annotation 4 ALA B  61
TYR B  60
GLY B  26
LEU B  72
 EDO  B 202 ( 3.8A)
None
None
None
 1.01A 5eslA-5m13B:
undetectable		 5eslA-5m13B:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)

(synthetic
construct) 		no annotation 4 ALA C  61
TYR C  60
GLY C  26
LEU C  72
 None
 0.94A 5eslA-5m15C:
undetectable		 5eslA-5m15C:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3c DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		no annotation 4 ALA A1014
TYR A1000
GLY A1041
LEU A 996
 None
 0.97A 5eslA-5m3cA:
undetectable		 5eslA-5m3cA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 504
PRO A 499
GLY A 430
LEU A 435
 None
 1.01A 5eslA-5n9xA:
undetectable		 5eslA-5n9xA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 ALA A1056
PRO A 864
GLY A 869
LEU A 893
 None
 1.01A 5eslA-5ngyA:
undetectable		 5eslA-5ngyA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 ALA A 257
PRO A 432
GLY A 307
LEU A 234
 None
 0.92A 5eslA-5oc1A:
undetectable		 5eslA-5oc1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 ALA A 293
TYR A 292
PRO A1123
GLY A1161
 None
None
None
PEG  A1214 (-4.5A)
 0.99A 5eslA-5u09A:
undetectable		 5eslA-5u09A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 191
TYR A 194
PRO A 217
GLY A 101
LEU A 221
 None
 1.48A 5eslA-5u7qA:
undetectable		 5eslA-5u7qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA

(Yersinia pestis) 		PF01297
(ZnuA) 		5 ALA A 179
TYR A 178
PRO A 146
GLY A 208
LEU A 297
 None
 0.96A 5eslA-5uygA:
undetectable		 5eslA-5uygA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3

(Pseudomonas
aeruginosa) 		PF09615
(Cas_Csy3) 		4 ALA C 273
PRO C  39
GLY C 221
LEU C 161
 None
 0.78A 5eslA-5uz9C:
undetectable		 5eslA-5uz9C:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 303
TYR A 302
PRO A 297
LEU A 269
 None
 0.98A 5eslA-5w95A:
undetectable		 5eslA-5w95A:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 ALA A 235
PRO A 281
GLY A 322
LEU A 265
 None
 0.95A 5eslA-5x7hA:
undetectable		 5eslA-5x7hA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 4 ALA A  14
PRO A 217
GLY A 212
LEU A 194
 None
 0.96A 5eslA-5x8hA:
undetectable		 5eslA-5x8hA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 ALA A 768
TYR A 779
GLY A 718
LEU A 687
 None
 0.78A 5eslA-5ywzA:
undetectable		 5eslA-5ywzA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A  58
TYR A  77
GLY A 278
LEU A  71
 EDO  A 305 (-3.6A)
None
None
None
 0.95A 5eslA-6b5eA:
undetectable		 5eslA-6b5eA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 269
PRO A 250
GLY A   3
LEU A  65
 None
 0.97A 5eslA-6b5eA:
undetectable		 5eslA-6b5eA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9u DNA GYRASE, SUBUNIT
B:SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
abortus) 		no annotation 4 ALA A  14
PRO A 222
GLY A 217
LEU A 195
 None
None
None
NAI  A 301 ( 4.5A)
 0.79A 5eslA-6b9uA:
undetectable		 5eslA-6b9uA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 4 ALA A 736
TYR A 740
GLY A1091
LEU A1170
 None
 0.98A 5eslA-6d4jA:
undetectable		 5eslA-6d4jA:
10.61