SIMILAR PATTERNS OF AMINO ACIDS FOR 5ESL_A_1YNA701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 GLY A 194
TYR A 237
ILE A 235
GLY A 201
HIS A 191
 None
 1.30A 5eslA-1c0nA:
undetectable		 5eslA-1c0nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		6 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
MET A 517
 None
 1.35A 5eslA-1d0nA:
0.3		 5eslA-1d0nA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02783
(MCR_beta_N) 		5 GLY A 475
PHE B 376
ILE B 375
GLY B 369
MET A 483
 None
None
None
TP7  A1554 ( 3.9A)
None
 1.20A 5eslA-1e6vA:
0.0		 5eslA-1e6vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9k ACIDIC LECTIN

(Psophocarpus
tetragonolobus) 		PF00139
(Lectin_legB) 		5 GLY A 158
GLY A 106
THR A 212
PHE A 153
THR A  78
 NAG  A 501 (-4.2A)
AMG  A 400 (-3.2A)
None
None
NAG  A 503 ( 3.9A)
 1.26A 5eslA-1f9kA:
undetectable		 5eslA-1f9kA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 TYR B   4
PHE B  71
GLY B 102
HIS B  53
THR B  51
 None
 1.14A 5eslA-1htrB:
undetectable		 5eslA-1htrB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP

(Drosophila
melanogaster) 		PF07651
(ANTH) 		5 GLY A 115
TYR A 140
GLY A  38
PHE A 111
THR A 116
 None
 1.19A 5eslA-1hx8A:
0.9		 5eslA-1hx8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		5 GLY A  82
PHE A 227
ILE A 233
GLY A 224
THR A  95
 None
 1.29A 5eslA-1i2oA:
0.0		 5eslA-1i2oA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03372
(Exo_endo_phos) 		5 PHE A 686
ILE A 660
TYR A 688
PHE A 695
HIS A 827
 None
 1.17A 5eslA-1i9zA:
0.0		 5eslA-1i9zA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		5 GLY A 261
ILE A 118
GLY A  85
PHE A 376
THR A 263
 None
 1.18A 5eslA-1k1dA:
undetectable		 5eslA-1k1dA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 5 GLY A 135
PHE A  13
ILE A  16
TYR A  17
GLY A 271
 None
 1.19A 5eslA-1nluA:
undetectable		 5eslA-1nluA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		5 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
 None
 1.10A 5eslA-1nphA:
undetectable		 5eslA-1nphA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		5 GLY A 547
TYR A 464
PHE A 441
THR A 549
MET A 517
 None
 1.19A 5eslA-1nphA:
undetectable		 5eslA-1nphA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		5 GLY A 237
PHE A 320
GLY A 307
THR A  98
THR A 239
 K  A 502 ( 4.7A)
None
None
None
None
 1.07A 5eslA-1p9eA:
undetectable		 5eslA-1p9eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 GLY A 160
TYR A  95
GLY A  88
PHE A  78
THR A 162
 None
 1.19A 5eslA-1sfrA:
undetectable		 5eslA-1sfrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		5 GLY A  93
PHE A  71
ILE A  73
PHE A  31
THR A  95
 None
 1.20A 5eslA-1smrA:
undetectable		 5eslA-1smrA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tie ERYTHRINA TRYPSIN
INHIBITOR

(Erythrina
caffra) 		PF00197
(Kunitz_legume) 		5 GLY A  13
ILE A 144
GLY A  27
PHE A 117
THR A  15
 None
 1.29A 5eslA-1tieA:
undetectable		 5eslA-1tieA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		5 GLY A 638
TYR A 649
PHE A 674
GLY A 695
THR A 717
 None
 1.16A 5eslA-1vrqA:
undetectable		 5eslA-1vrqA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdn GLUTAMINE BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		5 GLY A 119
TYR A  86
ILE A 216
GLY A  26
HIS A 156
 GLN  A 227 (-3.9A)
None
None
None
GLN  A 227 (-4.0A)
 1.18A 5eslA-1wdnA:
undetectable		 5eslA-1wdnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 GLY A  55
TYR A 362
ILE A 334
GLY A 368
THR A 405
 None
 1.21A 5eslA-1wzaA:
undetectable		 5eslA-1wzaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4i AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		5 GLY A 140
TYR A 233
ILE A 220
GLY A 251
THR A  12
 None
BTN  A1275 (-4.6A)
None
None
None
 1.14A 5eslA-2c4iA:
undetectable		 5eslA-2c4iA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkn 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Pseudomonas sp.
B-0831) 		PF13561
(adh_short_C2) 		5 GLY A 175
ILE A  13
GLY A 113
THR A 161
HIS A 236
 None
NAI  A4000 (-4.0A)
None
None
None
 1.27A 5eslA-2dknA:
undetectable		 5eslA-2dknA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		5 GLY A 189
TYR A 359
PHE A  24
PHE A  32
THR A 314
 None
 1.30A 5eslA-2dr1A:
undetectable		 5eslA-2dr1A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1d TRANSALDOLASE

(Mus musculus) 		PF00923
(TAL_FSA) 		5 GLY A  92
PHE A 238
ILE A 244
GLY A 235
THR A 105
 None
 1.26A 5eslA-2e1dA:
0.4		 5eslA-2e1dA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 190
ILE A 319
GLY A 280
THR A 264
PHE A 409
 None
 1.16A 5eslA-2gqdA:
undetectable		 5eslA-2gqdA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		5 GLY A  44
PHE A 353
ILE A 366
PHE A 302
GLY A 203
 None
 1.25A 5eslA-2ibpA:
1.4		 5eslA-2ibpA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		5 GLY A 171
ILE A 307
GLY A 343
THR A  53
PHE A 244
 None
None
None
None
NHE  A   1 (-3.6A)
 1.29A 5eslA-2ichA:
undetectable		 5eslA-2ichA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		5 GLY A 171
PHE A 333
ILE A 307
THR A  53
PHE A 244
 None
None
None
None
NHE  A   1 (-3.6A)
 1.24A 5eslA-2ichA:
undetectable		 5eslA-2ichA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		5 GLY A 217
PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.95A 5eslA-2jfwA:
undetectable		 5eslA-2jfwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		5 GLY A 358
PHE A  28
ILE A   4
TYR A  19
PHE A 231
 None
 1.20A 5eslA-2p0oA:
undetectable		 5eslA-2p0oA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1g PUTATIVE XYLANASE

(Bacteroides
fragilis) 		PF07313
(DUF1460) 		5 GLY A 210
TYR A 148
GLY A 203
THR A 201
HIS A 208
 None
 1.24A 5eslA-2p1gA:
undetectable		 5eslA-2p1gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qom SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		5 GLY A1140
ILE A1250
GLY A1246
PHE A1183
THR A1141
 None
 1.26A 5eslA-2qomA:
undetectable		 5eslA-2qomA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		5 GLY A 806
ILE A 696
GLY A 591
THR A 664
MET A 657
 SO4  A   1 ( 4.6A)
None
None
None
RIE  A 876 (-4.1A)
 1.11A 5eslA-2r4fA:
undetectable		 5eslA-2r4fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		5 TYR A 541
PHE A 534
ILE A 537
GLY A 509
PHE A 212
 None
 1.19A 5eslA-2rfoA:
undetectable		 5eslA-2rfoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 GLY A 401
TYR A 459
GLY A 287
THR A 283
THR A 374
 NI  A1614 (-3.7A)
None
None
None
None
 1.19A 5eslA-2uvfA:
undetectable		 5eslA-2uvfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 GLY A  60
ILE A 242
TYR A 245
THR A  45
THR A   8
 None
NAP  A 701 (-3.8A)
NAP  A 701 (-4.6A)
None
None
 1.09A 5eslA-2y05A:
undetectable		 5eslA-2y05A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 GLY A 270
TYR A 335
GLY A 659
PHE A 311
THR A 268
 None
GOL  A 901 ( 4.7A)
FAD  A 801 (-3.8A)
None
None
 1.24A 5eslA-2yr5A:
undetectable		 5eslA-2yr5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.04A 5eslA-3bs8A:
undetectable		 5eslA-3bs8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		5 GLY A 248
TYR A  39
ILE A 328
PHE A 301
THR A  59
 None
 1.26A 5eslA-3c9fA:
undetectable		 5eslA-3c9fA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		5 ILE A 410
GLY A 338
THR A 312
HIS A 180
PHE A  63
 None
None
None
ZN  A 501 (-3.1A)
None
 1.25A 5eslA-3dc8A:
undetectable		 5eslA-3dc8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		5 GLY A  36
PHE A 395
ILE A 386
GLY A 321
THR A 343
 None
 1.07A 5eslA-3dmsA:
undetectable		 5eslA-3dmsA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		5 GLY A 403
ILE A 159
TYR A 160
PHE A 137
THR A 107
 None
 1.00A 5eslA-3dwcA:
undetectable		 5eslA-3dwcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 375
ILE A 232
TYR A 233
GLY A  18
HIS A 305
 None
 1.15A 5eslA-3e1hA:
undetectable		 5eslA-3e1hA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 375
ILE A 232
TYR A 233
GLY A  18
HIS A 305
 None
 1.05A 5eslA-3euoA:
undetectable		 5eslA-3euoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4s PUTATIVE
UNCHARACTERIZED
PROTEIN

(Wolbachia
endosymbiont of
Drosophila
melanogaster) 		PF13462
(Thioredoxin_4) 		5 GLY A  88
PHE A 202
ILE A 177
GLY A 194
THR A  50
 None
 1.13A 5eslA-3f4sA:
undetectable		 5eslA-3f4sA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 198
TYR A 207
GLY A 158
THR A 223
HIS A 251
 None
 1.22A 5eslA-3gazA:
undetectable		 5eslA-3gazA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		5 GLY A  14
PHE A  79
ILE A  81
GLY A 235
THR A 244
 FAD  A 536 (-3.3A)
VAK  A 537 (-4.7A)
None
None
None
 1.09A 5eslA-3ihgA:
undetectable		 5eslA-3ihgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		5 GLY A 378
TYR A  63
ILE A  64
THR A 179
PHE A  71
 None
 1.18A 5eslA-3l5aA:
undetectable		 5eslA-3l5aA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 334
PHE A  57
PHE A 199
HIS A 296
THR A 330
 None
 1.24A 5eslA-3ledA:
undetectable		 5eslA-3ledA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls2 S-FORMYLGLUTATHIONE
HYDROLASE

(Pseudoalteromonas
haloplanktis) 		PF00756
(Esterase) 		5 TYR A  96
PHE A 104
GLY A 182
HIS A 146
MET A 148
 None
 1.26A 5eslA-3ls2A:
undetectable		 5eslA-3ls2A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00287
(Na_K-ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
 None
 1.13A 5eslA-3n23B:
undetectable		 5eslA-3n23B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 374
ILE A 236
TYR A 237
GLY A  23
HIS A 303
 None
 1.22A 5eslA-3ov3A:
undetectable		 5eslA-3ov3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacterium
tuberculosis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A 101
THR A 260
HIS A  36
PHE A 143
THR A 291
 ADP  A 307 (-4.3A)
None
None
None
None
 1.17A 5eslA-3pygA:
undetectable		 5eslA-3pygA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  41
TYR A   9
PHE A 102
GLY A  66
THR A  38
 None
 1.16A 5eslA-3q4dA:
undetectable		 5eslA-3q4dA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A  78
ILE A 353
GLY A 308
THR A 213
HIS A 178
 None
 1.15A 5eslA-3r44A:
undetectable		 5eslA-3r44A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		5 GLY A 261
ILE A 118
GLY A  85
PHE A 376
THR A 263
 None
 1.26A 5eslA-3sfwA:
undetectable		 5eslA-3sfwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 PHE A  48
ILE A  47
TYR A 299
GLY A 228
HIS A 158
 None
 1.20A 5eslA-3tqoA:
undetectable		 5eslA-3tqoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 398
ILE A  62
GLY A  82
HIS A  87
THR A 399
 None
 1.07A 5eslA-3u4aA:
undetectable		 5eslA-3u4aA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		5 GLY A 125
PHE A 225
ILE A 214
GLY A 237
THR A 203
 None
 1.20A 5eslA-3vbeA:
undetectable		 5eslA-3vbeA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		5 GLY A 128
PHE A 225
ILE A 214
GLY A 237
THR A 203
 None
 1.29A 5eslA-3vbeA:
undetectable		 5eslA-3vbeA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		5 TYR A 385
ILE A 377
GLY A 372
THR A 312
THR A 318
 None
 1.17A 5eslA-3wrfA:
undetectable		 5eslA-3wrfA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		5 TYR A  94
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.17A 5eslA-4b6gA:
undetectable		 5eslA-4b6gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1r MANNOSYL-6-PHOSPHATA
SE

(Bacteroides
thetaiotaomicron) 		PF03372
(Exo_endo_phos) 		5 GLY A  86
PHE A 256
PHE A 156
THR A 152
THR A 110
 None
 1.22A 5eslA-4c1rA:
undetectable		 5eslA-4c1rA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 TYR A 494
ILE A 541
GLY A 553
PHE A 493
THR A 460
 None
 1.11A 5eslA-4d72A:
undetectable		 5eslA-4d72A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		5 GLY A 421
ILE A 494
TYR A 101
GLY A  85
THR A 292
 None
 1.23A 5eslA-4f7aA:
0.0		 5eslA-4f7aA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2

(Pleurotus
eryngii) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 GLY A 176
PHE A  29
ILE A  24
GLY A 107
THR A  45
 HEM  A 401 (-3.4A)
None
None
None
HEM  A 401 ( 4.9A)
 1.28A 5eslA-4fcsA:
undetectable		 5eslA-4fcsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i66 UNCHARACTERIZED
PROTEIN HOCH_4089

(Haliangium
ochraceum) 		PF13709
(DUF4159) 		5 GLY A 183
PHE A  33
ILE A  58
PHE A  85
HIS A 154
 None
 1.30A 5eslA-4i66A:
undetectable		 5eslA-4i66A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilf THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBC

(Salmonella
enterica) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		5 GLY A 155
ILE A 116
GLY A 198
HIS A 102
PHE A 149
 None
 1.30A 5eslA-4ilfA:
undetectable		 5eslA-4ilfA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 188
ILE A 317
GLY A 278
THR A 262
PHE A 407
 None
 1.15A 5eslA-4ls5A:
undetectable		 5eslA-4ls5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqb THYMIDYLATE KINASE

(Staphylococcus
aureus) 		PF02223
(Thymidylate_kin) 		5 GLY A  39
ILE A 142
GLY A  14
THR A  17
THR A  35
 None
None
PG4  A 302 (-3.5A)
PG4  A 302 (-3.8A)
None
 1.24A 5eslA-4mqbA:
undetectable		 5eslA-4mqbA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		5 GLY A 150
TYR A 196
ILE A 194
GLY A 210
THR A 152
 None
X1X  A 401 (-3.7A)
None
None
None
 1.25A 5eslA-4nx1A:
undetectable		 5eslA-4nx1A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7q LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Chitinophaga
pinensis) 		PF13472
(Lipase_GDSL_2) 		5 TYR A 241
ILE A 154
TYR A 239
PHE A 227
THR A 201
 None
 1.30A 5eslA-4q7qA:
undetectable		 5eslA-4q7qA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnw CHANOCLAVINE-I
ALDEHYDE REDUCTASE

(Aspergillus
fumigatus) 		PF00724
(Oxidored_FMN) 		5 GLY A 111
ILE A 214
GLY A 223
PHE A 205
THR A 110
 None
 1.12A 5eslA-4qnwA:
undetectable		 5eslA-4qnwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlp CHYMOTRYPSIN
INHIBITOR 3

(Psophocarpus
tetragonolobus) 		PF00197
(Kunitz_legume) 		5 GLY A  18
ILE A 153
GLY A  32
PHE A 122
THR A  20
 None
 1.27A 5eslA-4tlpA:
undetectable		 5eslA-4tlpA:
15.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		6 GLY A  69
TYR A 122
PHE A 130
TYR A 136
PHE A 229
HIS A 374
 None
VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
 1.07A 5eslA-4uymA:
51.4		 5eslA-4uymA:
50.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmp HEAVY CHAIN OF
ANTIBODY VRC08

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  85
ILE H  34
GLY H 104
PHE H  63
THR H  87
 None
 1.08A 5eslA-4xmpH:
undetectable		 5eslA-4xmpH:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		5 GLY A 391
ILE A 262
PHE A 248
GLY A 244
THR A 328
 None
 1.27A 5eslA-4xydA:
undetectable		 5eslA-4xydA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		5 GLY C  35
ILE C 182
PHE C 232
THR C  91
MET C 100
 None
 1.22A 5eslA-5a53C:
undetectable		 5eslA-5a53C:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgy HEAVY CHAIN OF FAB

(Homo sapiens) 		no annotation 5 GLY H  89
ILE H  34
GLY H 118
PHE H  64
THR H  91
 None
 1.04A 5eslA-5cgyH:
undetectable		 5eslA-5cgyH:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		5 GLY A  76
TYR A 291
ILE A 262
TYR A 289
PHE A 298
 C8E  A 501 (-3.4A)
None
None
None
None
 1.23A 5eslA-5dl5A:
undetectable		 5eslA-5dl5A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		11 GLY A  65
TYR A 118
PHE A 126
ILE A 131
TYR A 132
PHE A 228
GLY A 307
THR A 311
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.49A 5eslA-5fsaA:
57.3		 5eslA-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 GLY A 265
PHE A  95
ILE A  66
GLY A  90
PHE A 279
 None
 1.16A 5eslA-5g37A:
undetectable		 5eslA-5g37A:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 GLY A  73
GLY A 315
THR A 318
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
None
None
 0.84A 5eslA-5hs1A:
63.1		 5eslA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 GLY A  73
TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
None
 0.49A 5eslA-5hs1A:
63.1		 5eslA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		12 GLY A  74
TYR A 127
PHE A 135
ILE A 140
TYR A 141
PHE A 237
GLY A 315
THR A 319
HIS A 382
PHE A 385
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.53A 5eslA-5jlcA:
59.3		 5eslA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 GLY A 316
THR A 319
HIS A 382
THR A 510
MET A 512
 HEM  A 601 (-3.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 1.05A 5eslA-5jlcA:
59.3		 5eslA-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 GLY A 288
ILE A 353
GLY A 307
THR A 290
MET A 281
 NAG  A 905 (-3.5A)
None
None
None
None
 1.26A 5eslA-5m60A:
undetectable		 5eslA-5m60A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.04A 5eslA-5m7rA:
undetectable		 5eslA-5m7rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqf APICAL MEMBRANE
ANTIGEN 1

(Plasmodium
falciparum) 		PF02430
(AMA-1) 		5 GLY A 179
PHE A 342
ILE A 127
GLY A 153
THR A 164
 GLY  A 179 ( 0.0A)
PHE  A 342 ( 1.3A)
ILE  A 127 ( 0.7A)
GLY  A 153 ( 0.0A)
THR  A 164 ( 0.8A)
 1.20A 5eslA-5nqfA:
undetectable		 5eslA-5nqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 GLY A 489
PHE A 449
ILE A 516
TYR A 453
THR A 156
 CL  A1001 ( 3.8A)
None
None
None
None
 1.22A 5eslA-5nz7A:
undetectable		 5eslA-5nz7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 435
ILE A  90
GLY A 110
HIS A 115
THR A 436
 None
 1.13A 5eslA-5tf0A:
undetectable		 5eslA-5tf0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.02A 5eslA-5uhkA:
undetectable		 5eslA-5uhkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.16A 5eslA-5vvoA:
undetectable		 5eslA-5vvoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxl RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		5 GLY A  35
ILE A 182
PHE A 232
THR A  91
MET A 100
 None
 1.29A 5eslA-5wxlA:
undetectable		 5eslA-5wxlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yow GLYCOPROTEIN
POLYPROTEIN

(Heartland virus) 		no annotation 5 GLY A 418
PHE A 328
ILE A 172
GLY A 326
HIS A 378
 None
 1.24A 5eslA-5yowA:
undetectable		 5eslA-5yowA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 5 TYR A 107
PHE A 114
TYR A 120
PHE A 292
THR A 297
 TPF  A 506 (-4.2A)
TPF  A 506 (-4.4A)
None
TPF  A 506 ( 4.0A)
HEM  A 501 (-3.4A)
 1.27A 5eslA-6ay4A:
42.1		 5eslA-6ay4A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 5 TYR A 107
PHE A 114
TYR A 120
THR A 297
THR A 465
 TPF  A 506 (-4.2A)
TPF  A 506 (-4.4A)
None
HEM  A 501 (-3.4A)
None
 0.74A 5eslA-6ay4A:
42.1		 5eslA-6ay4A:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 5 GLY A  40
PHE A 399
ILE A 390
GLY A 324
THR A 347
 None
None
None
None
EE1  A 501 (-3.6A)
 1.29A 5eslA-6c0eA:
undetectable		 5eslA-6c0eA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 GLY A 315
TYR A 135
TYR A 149
GLY A 198
THR A  81
 EQG  A 504 (-3.5A)
None
None
None
None
 1.16A 5eslA-6c4gA:
undetectable		 5eslA-6c4gA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1
TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 5 GLY B   9
ILE I 703
GLY I 677
HIS B  30
THR B  13
 None
 1.26A 5eslA-6emkB:
undetectable		 5eslA-6emkB:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 5 GLY A 185
PHE A 492
ILE A 104
THR A 239
THR A 197
 FAD  A 601 (-3.5A)
None
None
None
None
 1.30A 5eslA-6eo5A:
undetectable		 5eslA-6eo5A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ALA A 693
TYR A 127
PRO A 324
GLY A 319
 None
ADP  A 998 (-4.4A)
None
None
 0.95A 5eslA-1br2A:
0.0		 5eslA-1br2A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		4 ALA A 541
PRO A 234
GLY A  73
LEU A 200
 None
None
HEM  A 800 ( 4.2A)
None
 1.00A 5eslA-1ehkA:
1.3		 5eslA-1ehkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		4 ALA A 312
PRO A 468
GLY A 185
LEU A 326
 None
 0.93A 5eslA-1f0iA:
undetectable		 5eslA-1f0iA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 ALA A 332
TYR A 335
GLY A 265
LEU A 284
 None
 0.89A 5eslA-1ileA:
0.0		 5eslA-1ileA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 450
PRO A 368
GLY A 334
LEU A 362
 None
 1.02A 5eslA-1k4qA:
0.0		 5eslA-1k4qA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 ALA A 233
TYR A  80
GLY A 339
LEU A   6
 None
 0.87A 5eslA-1mb9A:
0.3		 5eslA-1mb9A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		4 ALA A 116
PRO A 109
GLY A  22
LEU A  62
 None
 0.98A 5eslA-1n1aA:
undetectable		 5eslA-1n1aA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ALA A 217
TYR A 218
PRO A 408
GLY A 379
 None
 0.95A 5eslA-1obbA:
0.0		 5eslA-1obbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		4 ALA A  26
PRO A  11
GLY A 135
LEU A 116
 None
None
4TP  A 332 ( 4.0A)
None
 1.02A 5eslA-1ps6A:
undetectable		 5eslA-1ps6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1

(Rattus
norvegicus) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 ALA A 290
TYR A 295
PRO A 722
GLY A 664
 None
 1.01A 5eslA-1qasA:
undetectable		 5eslA-1qasA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		4 ALA A 239
TYR A 233
GLY A 148
LEU A  52
 None
 0.98A 5eslA-1smlA:
undetectable		 5eslA-1smlA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		4 ALA A 332
TYR A 335
GLY A 265
LEU A 284
 None
 0.87A 5eslA-1ue0A:
undetectable		 5eslA-1ue0A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 ALA A 146
PRO A 161
GLY A  41
LEU A 188
 None
None
SO4  A 245 (-3.3A)
None
 1.02A 5eslA-1vplA:
undetectable		 5eslA-1vplA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 ALA A 218
PRO A 295
GLY A 346
LEU A 341
 None
 0.84A 5eslA-1yiqA:
undetectable		 5eslA-1yiqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		4 TYR A 258
PRO A 168
GLY A 162
LEU A 242
 None
 1.00A 5eslA-1z6rA:
undetectable		 5eslA-1z6rA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		4 ALA A  28
PRO A 210
GLY A 169
LEU A 213
 None
 0.98A 5eslA-1z7aA:
undetectable		 5eslA-1z7aA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvh IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA A  61
TYR A  60
GLY A  26
LEU A  72
 None
 1.02A 5eslA-1zvhA:
undetectable		 5eslA-1zvhA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00266
(Aminotran_5) 		4 ALA A 250
PRO A  61
GLY A  68
LEU A 267
 None
None
PLP  A1201 (-3.6A)
None
 1.02A 5eslA-2bkwA:
undetectable		 5eslA-2bkwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		4 ALA A 528
TYR A 531
GLY A 261
LEU A 385
 None
 0.78A 5eslA-2f5uA:
undetectable		 5eslA-2f5uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ALA A  93
TYR A   3
PRO A  89
GLY A  51
 None
 0.99A 5eslA-2gcaA:
undetectable		 5eslA-2gcaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 ALA A 743
TYR A 742
GLY A 847
LEU A 617
 None
 0.74A 5eslA-2hg4A:
0.4		 5eslA-2hg4A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 ALA A 136
TYR A 135
GLY A  72
LEU A  81
 None
None
None
CSO  A  82 ( 4.4A)
 0.84A 5eslA-2nqaA:
undetectable		 5eslA-2nqaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT

(Mus musculus) 		PF05843
(Suf) 		4 ALA A 297
TYR A 300
GLY A 175
LEU A 271
 None
 0.88A 5eslA-2ooeA:
undetectable		 5eslA-2ooeA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR

(Caldanaerobacter
subterraneus) 		PF00079
(Serpin) 		4 ALA A  88
PRO A 413
GLY A 262
LEU A 292
 None
 1.00A 5eslA-2pefA:
undetectable		 5eslA-2pefA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		4 ALA B 205
PRO B 239
GLY B 511
LEU B 232
 None
 1.00A 5eslA-2pffB:
undetectable		 5eslA-2pffB:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ALA A 752
TYR A 751
GLY A 855
LEU A 626
 None
ACT  A 950 ( 4.5A)
None
None
 0.98A 5eslA-2qo3A:
0.7		 5eslA-2qo3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1v DJ-1

(Homo sapiens) 		PF01965
(DJ-1_PfpI) 		4 ALA A  14
PRO A  22
GLY A 174
LEU A 153
 None
 0.99A 5eslA-2r1vA:
undetectable		 5eslA-2r1vA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		4 ALA A 207
PRO A 215
GLY A 110
LEU A 222
 None
 0.97A 5eslA-2r7dA:
undetectable		 5eslA-2r7dA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 175
TYR A 178
GLY A  85
LEU A 205
 None
None
ANP  A1480 ( 3.8A)
ANP  A1480 ( 4.7A)
 0.99A 5eslA-2v55A:
undetectable		 5eslA-2v55A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhq NTPASE P4

(Pseudomonas
phage phi12) 		PF11602
(NTPase_P4) 		4 ALA A 154
TYR A 153
GLY A 132
LEU A 294
 None
 1.01A 5eslA-2vhqA:
undetectable		 5eslA-2vhqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		4 ALA A 367
TYR A 364
GLY A 228
LEU A 156
 None
 0.98A 5eslA-2vugA:
undetectable		 5eslA-2vugA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxb DNA REPAIR PROTEIN
RHP9

(Schizosaccharomyces
pombe) 		PF00533
(BRCT) 		4 ALA A 199
TYR A 202
GLY A  50
LEU A  60
 None
 0.95A 5eslA-2vxbA:
undetectable		 5eslA-2vxbA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE

(Rhodothermus
marinus) 		no annotation 4 ALA A 319
TYR A 322
GLY A 203
LEU A 240
 None
 0.93A 5eslA-2y4lA:
undetectable		 5eslA-2y4lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 ALA A  80
PRO A 341
GLY A  12
LEU A  57
 None
 0.82A 5eslA-2y9xA:
undetectable		 5eslA-2y9xA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 339
PRO A  80
GLY A 140
LEU A 121
 None
 1.00A 5eslA-2z1qA:
undetectable		 5eslA-2z1qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		4 ALA A 213
TYR A 216
GLY A 384
LEU A 465
 None
 1.01A 5eslA-2ze4A:
undetectable		 5eslA-2ze4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		4 ALA A 307
PRO A 462
GLY A 183
LEU A 321
 None
 0.94A 5eslA-2ze4A:
undetectable		 5eslA-2ze4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ALA A 159
TYR A 158
PRO A 200
GLY A 231
 None
 0.79A 5eslA-3aatA:
undetectable		 5eslA-3aatA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e29 UNCHARACTERIZED
PROTEIN Q7WE92_BORBR

(Bordetella
bronchiseptica) 		PF03061
(4HBT) 		4 ALA A 110
TYR A 131
GLY A 121
LEU A  61
 None
 1.00A 5eslA-3e29A:
undetectable		 5eslA-3e29A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go1 FAB 268-D, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA L 173
TYR L 172
PRO L  40
GLY L  99
 None
 0.90A 5eslA-3go1L:
undetectable		 5eslA-3go1L:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ALA B 357
PRO B 412
GLY B 295
LEU B 310
 None
 0.97A 5eslA-3h32B:
undetectable		 5eslA-3h32B:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		4 ALA A  45
TYR A  49
PRO A  78
GLY A 111
 None
 1.00A 5eslA-3hgoA:
undetectable		 5eslA-3hgoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 ALA A 366
TYR A 367
GLY A 265
LEU A 382
 None
 0.98A 5eslA-3ifsA:
1.0		 5eslA-3ifsA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ite SIDN SIDEROPHORE
SYNTHETASE

(Epichloe
festucae) 		PF00501
(AMP-binding) 		4 ALA A  25
TYR A  53
GLY A 349
LEU A 239
 None
 0.74A 5eslA-3iteA:
undetectable		 5eslA-3iteA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 277
PRO A 293
GLY A  88
LEU A 183
 None
None
None
NAD  A 503 (-3.7A)
 0.99A 5eslA-3jv7A:
undetectable		 5eslA-3jv7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		4 ALA A 130
TYR A 131
GLY A 112
LEU A   6
 None
 0.96A 5eslA-3l4eA:
undetectable		 5eslA-3l4eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngf AP ENDONUCLEASE,
FAMILY 2

(Brucella
abortus) 		PF01261
(AP_endonuc_2) 		4 ALA A 254
TYR A 256
PRO A 213
LEU A 223
 None
 0.97A 5eslA-3ngfA:
undetectable		 5eslA-3ngfA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 ALA A 170
PRO A 130
GLY A 146
LEU A 134
 None
None
None
NAD  A 400 (-4.0A)
 0.99A 5eslA-3qbdA:
undetectable		 5eslA-3qbdA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii) 		PF12146
(Hydrolase_4) 		4 ALA A 116
PRO A 131
GLY A 222
LEU A 217
 CL  A 292 ( 3.7A)
None
NA  A 280 (-4.0A)
NA  A 281 ( 4.3A)
 1.00A 5eslA-3qm1A:
undetectable		 5eslA-3qm1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
marinum) 		no annotation 4 ALA B  15
PRO B 217
GLY B 212
LEU B 193
 None
 0.95A 5eslA-3tzqB:
undetectable		 5eslA-3tzqB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		4 TYR A 191
PRO A 159
GLY A 221
LEU A 310
 None
 0.95A 5eslA-3ujpA:
undetectable		 5eslA-3ujpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13534
(Fer4_17) 		4 TYR B 146
PRO A  75
GLY A 420
LEU A 184
 None
None
FAD  A 702 (-3.6A)
None
 1.00A 5eslA-3vrbB:
undetectable		 5eslA-3vrbB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 ALA A 227
PRO A 133
GLY A 270
LEU A 254
 None
 1.01A 5eslA-3wibA:
undetectable		 5eslA-3wibA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ALA A 262
TYR A 282
GLY A 346
LEU A 273
 None
 0.92A 5eslA-3zyvA:
undetectable		 5eslA-3zyvA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 ALA A 100
TYR A  99
PRO A 221
GLY A 286
 None
 1.00A 5eslA-4a7kA:
undetectable		 5eslA-4a7kA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		4 ALA A 180
PRO A 184
GLY A 189
LEU A 347
 None
 0.90A 5eslA-4ddqA:
0.7		 5eslA-4ddqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 ALA A 373
PRO A 319
GLY A 145
LEU A 109
 None
 0.93A 5eslA-4dshA:
undetectable		 5eslA-4dshA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		4 TYR A 243
PRO A  93
GLY A  43
LEU A  58
 None
 0.97A 5eslA-4g76A:
undetectable		 5eslA-4g76A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ALA A 178
PRO A 174
GLY A 310
LEU A 234
 None
 0.97A 5eslA-4jzyA:
undetectable		 5eslA-4jzyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		4 ALA A 337
TYR A 334
PRO A 258
GLY A 492
 None
 1.01A 5eslA-4k90A:
undetectable		 5eslA-4k90A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		4 ALA A 220
TYR A 221
PRO A 303
LEU A 205
 None
 0.92A 5eslA-4mfiA:
undetectable		 5eslA-4mfiA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4op4 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Vibrio cholerae) 		PF01546
(Peptidase_M20) 		4 ALA A 248
PRO A 233
GLY A 218
LEU A 106
 None
None
BU1  A 307 ( 3.7A)
None
 0.97A 5eslA-4op4A:
undetectable		 5eslA-4op4A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 ALA A 203
PRO A 294
GLY A 160
LEU A 171
 None
 0.97A 5eslA-4qwwA:
undetectable		 5eslA-4qwwA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ALA A 346
PRO A 214
GLY A 219
LEU A 235
 None
 1.02A 5eslA-4rjkA:
undetectable		 5eslA-4rjkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		4 ALA A 140
TYR A 143
GLY A 173
LEU A 262
 None
 0.99A 5eslA-4udnA:
undetectable		 5eslA-4udnA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN
INTRAFLAGELLAR
TRANSPORT PROTEIN
IFT52

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6)
no annotation 		4 ALA A 410
PRO A 416
GLY A 325
LEU B 343
 None
FLC  A1647 (-3.5A)
None
None
 0.92A 5eslA-4uzyA:
undetectable		 5eslA-4uzyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 ALA A 158
TYR A 157
PRO A 199
GLY A 230
 None
 0.96A 5eslA-4wb0A:
undetectable		 5eslA-4wb0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yze HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR NEMR

(Escherichia
coli) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		4 ALA A 165
TYR A 164
GLY A  28
LEU A 107
 None
 0.94A 5eslA-4yzeA:
undetectable		 5eslA-4yzeA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 ALA A 135
PRO A 175
GLY A 356
LEU A 126
 None
 0.91A 5eslA-4zr0A:
undetectable		 5eslA-4zr0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8d CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43) 		4 ALA A  46
PRO A 167
GLY A 155
LEU A 194
 GOL  A1340 (-4.1A)
None
None
None
 0.98A 5eslA-5a8dA:
undetectable		 5eslA-5a8dA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		4 ALA A 103
TYR A  81
GLY A 445
LEU A 248
 None
 0.99A 5eslA-5djsA:
undetectable		 5eslA-5djsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 ALA B 479
PRO B 562
GLY B 669
LEU B 608
 None
 0.94A 5eslA-5dlqB:
undetectable		 5eslA-5dlqB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MINOR STRUCTURAL
PROTEIN 5

(Lactococcus
phage Tuc2009) 		no annotation 4 ALA B  10
TYR B  11
GLY B 256
LEU B 235
 None
 0.88A 5eslA-5e7tB:
undetectable		 5eslA-5e7tB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		4 ALA A 303
TYR A 304
PRO A  53
GLY A  73
 NA  A 401 ( 4.7A)
None
None
None
 0.95A 5eslA-5evjA:
0.7		 5eslA-5evjA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ALA A 634
TYR A 637
GLY A 543
LEU A 664
 None
None
None
4ZS  A 901 (-3.6A)
 1.02A 5eslA-5ezrA:
undetectable		 5eslA-5ezrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f89 CAP248-2B LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 ALA L 174
TYR L 173
PRO L  40
GLY L  99
 None
 0.99A 5eslA-5f89L:
undetectable		 5eslA-5f89L:
17.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 ALA A  61
TYR A  64
PRO A 230
GLY A 303
LEU A 376
 X2N  A 590 (-3.5A)
None
X2N  A 590 (-4.2A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.3A)
 0.52A 5eslA-5fsaA:
57.3		 5eslA-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ALA A 153
PRO A 174
GLY A 281
LEU A 232
 None
 0.89A 5eslA-5gmsA:
undetectable		 5eslA-5gmsA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		4 ALA A 146
PRO A 193
GLY A 180
LEU A 171
 None
 1.00A 5eslA-5gwnA:
undetectable		 5eslA-5gwnA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 ALA A  69
TYR A  72
PRO A 238
GLY A 310
LEU A 380
 None
None
None
VOR  A 602 (-4.3A)
VOR  A 602 (-4.0A)
 0.48A 5eslA-5hs1A:
63.1		 5eslA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 ALA A  70
TYR A  73
PRO A 239
GLY A 311
LEU A 381
 1YN  A 602 (-3.4A)
1YN  A 602 (-4.9A)
1YN  A 602 ( 4.8A)
1YN  A 602 (-3.9A)
1YN  A 602 ( 4.7A)
 0.29A 5eslA-5jlcA:
59.3		 5eslA-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku7 TIR-NB-LRR TYPE
RESISTANCE PROTEIN
RPV1

(Vitis
rotundifolia) 		PF01582
(TIR) 		4 ALA A 136
TYR A 138
GLY A 161
LEU A  98
 None
 0.81A 5eslA-5ku7A:
undetectable		 5eslA-5ku7A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m13 SYNTHETIC NANOBODY
L2_C06 (A-MBP#2)

(synthetic
construct) 		no annotation 4 ALA B  61
TYR B  60
GLY B  26
LEU B  72
 EDO  B 202 ( 3.8A)
None
None
None
 1.01A 5eslA-5m13B:
undetectable		 5eslA-5m13B:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)

(synthetic
construct) 		no annotation 4 ALA C  61
TYR C  60
GLY C  26
LEU C  72
 None
 0.94A 5eslA-5m15C:
undetectable		 5eslA-5m15C:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3c DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		no annotation 4 ALA A1014
TYR A1000
GLY A1041
LEU A 996
 None
 0.97A 5eslA-5m3cA:
undetectable		 5eslA-5m3cA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 504
PRO A 499
GLY A 430
LEU A 435
 None
 1.01A 5eslA-5n9xA:
undetectable		 5eslA-5n9xA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 ALA A1056
PRO A 864
GLY A 869
LEU A 893
 None
 1.01A 5eslA-5ngyA:
undetectable		 5eslA-5ngyA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 ALA A 257
PRO A 432
GLY A 307
LEU A 234
 None
 0.92A 5eslA-5oc1A:
undetectable		 5eslA-5oc1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 ALA A 293
TYR A 292
PRO A1123
GLY A1161
 None
None
None
PEG  A1214 (-4.5A)
 0.99A 5eslA-5u09A:
undetectable		 5eslA-5u09A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 191
TYR A 194
PRO A 217
GLY A 101
LEU A 221
 None
 1.48A 5eslA-5u7qA:
undetectable		 5eslA-5u7qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA

(Yersinia pestis) 		PF01297
(ZnuA) 		5 ALA A 179
TYR A 178
PRO A 146
GLY A 208
LEU A 297
 None
 0.96A 5eslA-5uygA:
undetectable		 5eslA-5uygA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3

(Pseudomonas
aeruginosa) 		PF09615
(Cas_Csy3) 		4 ALA C 273
PRO C  39
GLY C 221
LEU C 161
 None
 0.78A 5eslA-5uz9C:
undetectable		 5eslA-5uz9C:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 303
TYR A 302
PRO A 297
LEU A 269
 None
 0.98A 5eslA-5w95A:
undetectable		 5eslA-5w95A:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 ALA A 235
PRO A 281
GLY A 322
LEU A 265
 None
 0.95A 5eslA-5x7hA:
undetectable		 5eslA-5x7hA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 4 ALA A  14
PRO A 217
GLY A 212
LEU A 194
 None
 0.96A 5eslA-5x8hA:
undetectable		 5eslA-5x8hA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 ALA A 768
TYR A 779
GLY A 718
LEU A 687
 None
 0.78A 5eslA-5ywzA:
undetectable		 5eslA-5ywzA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A  58
TYR A  77
GLY A 278
LEU A  71
 EDO  A 305 (-3.6A)
None
None
None
 0.95A 5eslA-6b5eA:
undetectable		 5eslA-6b5eA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 269
PRO A 250
GLY A   3
LEU A  65
 None
 0.97A 5eslA-6b5eA:
undetectable		 5eslA-6b5eA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9u DNA GYRASE, SUBUNIT
B:SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
abortus) 		no annotation 4 ALA A  14
PRO A 222
GLY A 217
LEU A 195
 None
None
None
NAI  A 301 ( 4.5A)
 0.79A 5eslA-6b9uA:
undetectable		 5eslA-6b9uA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 4 ALA A 736
TYR A 740
GLY A1091
LEU A1170
 None
 0.98A 5eslA-6d4jA:
undetectable		 5eslA-6d4jA:
10.61