SIMILAR PATTERNS OF AMINO ACIDS FOR 5ESH_A_1YNA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey1 ANTITERMINATION
FACTOR NUSB

(Escherichia
coli) 		PF01029
(NusB) 		4 TYR A  69
LEU A  92
PRO A 132
LEU A  62
 None
 1.40A 5eshA-1ey1A:
undetectable		 5eshA-1ey1A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg7 HUMANIZED ANTIBODY
D3H44

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H 176
LEU H 108
PRO H  41
LEU H  11
 None
 1.41A 5eshA-1pg7H:
undetectable		 5eshA-1pg7H:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pu7 3-METHYLADENINE DNA
GLYCOSYLASE

(Helicobacter
pylori) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 TYR A 140
LEU A  17
PRO A  21
LEU A 198
 None
KCX  A 205 ( 4.1A)
None
None
 1.47A 5eshA-1pu7A:
0.0		 5eshA-1pu7A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 TYR A 267
LEU A 248
PRO A 260
LEU A 181
 None
 1.49A 5eshA-1pyfA:
undetectable		 5eshA-1pyfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TRP A  12
LEU A 115
PRO A 111
LEU A   8
 None
 1.45A 5eshA-1q8iA:
0.3		 5eshA-1q8iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		4 TYR A 207
TRP A 218
PRO A 219
LEU A  63
 None
 1.36A 5eshA-1r76A:
0.0		 5eshA-1r76A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		4 TRP A 129
LEU A 126
PRO A 160
LEU A 106
 None
 1.46A 5eshA-1to3A:
0.0		 5eshA-1to3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 TYR A 187
LEU A 242
PRO A 240
LEU A 190
 None
 1.46A 5eshA-1up4A:
0.0		 5eshA-1up4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE

(Rattus
norvegicus) 		no annotation 4 TYR A 221
TRP A 143
PRO A 137
LEU A  33
 NMG  A 237 ( 4.7A)
None
None
None
 1.49A 5eshA-1xcjA:
undetectable		 5eshA-1xcjA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjq MFP2A

(Ascaris suum) 		PF12150
(MFP2b) 		4 TYR A  33
TRP A  49
LEU A 220
LEU A 186
 None
 1.33A 5eshA-2bjqA:
0.0		 5eshA-2bjqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 TYR A  51
TRP A  50
LEU A 184
LEU A 174
 None
 1.38A 5eshA-2bwsA:
undetectable		 5eshA-2bwsA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		4 TYR A 562
LEU A 147
PRO A 145
LEU A 411
 None
 1.47A 5eshA-2f5uA:
0.0		 5eshA-2f5uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE

(Lactobacillus
plantarum) 		PF04909
(Amidohydro_2) 		4 TRP A  30
LEU A  11
PRO A  33
LEU A  54
 None
 1.29A 5eshA-2f6kA:
undetectable		 5eshA-2f6kA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsz NOVEL PREDICTED
PHOSPHATASE

(Histophilus
somni) 		PF13419
(HAD_2) 		4 TYR A  97
LEU A  22
PRO A  20
LEU A  11
 None
UNL  A 227 (-4.8A)
None
None
 1.46A 5eshA-2hszA:
undetectable		 5eshA-2hszA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kuc PUTATIVE
DISULPHIDE-ISOMERASE

(Bacteroides
thetaiotaomicron) 		PF00085
(Thioredoxin) 		4 TRP A  35
LEU A  42
PRO A  38
LEU A 100
 None
 1.00A 5eshA-2kucA:
undetectable		 5eshA-2kucA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB

(Escherichia
coli) 		PF03888
(MucB_RseB)
PF17188
(MucB_RseB_C) 		4 TYR A 116
LEU A  45
PRO A 167
LEU A  73
 None
 1.11A 5eshA-2p4bA:
undetectable		 5eshA-2p4bA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6d DIPHTHINE SYNTHASE

(Pyrococcus
horikoshii) 		PF00590
(TP_methylase) 		4 TYR A 220
LEU A 242
PRO A 239
LEU A 261
 None
 1.29A 5eshA-2p6dA:
undetectable		 5eshA-2p6dA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 TRP A 251
LEU A 328
PRO A 283
LEU A 292
 None
 1.48A 5eshA-2qt3A:
0.0		 5eshA-2qt3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 TYR A 225
TRP A 163
LEU A 256
LEU A 208
 None
 1.39A 5eshA-2v28A:
undetectable		 5eshA-2v28A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		4 TYR A  46
TRP A 246
LEU A 262
LEU A 269
 None
 1.28A 5eshA-2vhaA:
undetectable		 5eshA-2vhaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 228
TRP A 246
LEU A 168
LEU A 153
 None
 1.22A 5eshA-2z7rA:
undetectable		 5eshA-2z7rA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 TYR A  82
LEU A 124
PRO A 132
LEU A  74
 None
 1.27A 5eshA-2zq5A:
undetectable		 5eshA-2zq5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0u UNCHARACTERIZED
PROTEIN YAEQ

(Escherichia
coli) 		PF07152
(YaeQ) 		4 TYR A  50
TRP A  47
LEU A  42
LEU A 104
 None
 1.35A 5eshA-3c0uA:
undetectable		 5eshA-3c0uA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbt PHOSPHATASE SC4828

(Streptomyces
coelicolor) 		PF04167
(DUF402) 		4 TRP A 130
LEU A  58
PRO A 204
LEU A 138
 TRP  A 130 (-0.5A)
LEU  A  58 ( 0.6A)
PRO  A 204 (-1.1A)
LEU  A 138 ( 0.6A)
 1.36A 5eshA-3cbtA:
undetectable		 5eshA-3cbtA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 TYR A 428
LEU A 532
PRO A 124
LEU A 510
 None
 1.36A 5eshA-3cv2A:
2.1		 5eshA-3cv2A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 TRP H  29
LEU H 212
PRO H 198
LEU H 106
 None
 1.09A 5eshA-3f6uH:
undetectable		 5eshA-3f6uH:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		4 TRP A  41
LEU A 127
PRO A 123
LEU A  88
 None
None
PG4  A   3 ( 4.5A)
None
 1.10A 5eshA-3h41A:
undetectable		 5eshA-3h41A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwg ACETYLTRANSFERASE,
GNAT FAMILY

(Colwellia
psychrerythraea) 		PF00583
(Acetyltransf_1) 		4 TYR A 200
LEU A  10
PRO A  38
LEU A  16
 None
 1.45A 5eshA-3iwgA:
undetectable		 5eshA-3iwgA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 TRP A 495
LEU A 478
PRO A 469
LEU A 531
 None
 1.36A 5eshA-3j0aA:
undetectable		 5eshA-3j0aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 194
TRP A 213
LEU A 133
LEU A 114
 None
 1.38A 5eshA-3mi9A:
undetectable		 5eshA-3mi9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 TYR X 248
TRP X 422
LEU X 340
PRO X 277
 None
None
None
PLP  X 502 ( 4.8A)
 1.42A 5eshA-3ss7X:
0.6		 5eshA-3ss7X:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uan HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
1

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		4 TYR A 192
LEU A 165
PRO A 176
LEU A 158
 None
 1.43A 5eshA-3uanA:
undetectable		 5eshA-3uanA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 TYR A 507
LEU A 704
PRO A 499
LEU A 584
 None
 1.39A 5eshA-4bp8A:
undetectable		 5eshA-4bp8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 TYR A 821
LEU A 858
PRO A 866
LEU A 918
 None
 1.45A 5eshA-4lglA:
undetectable		 5eshA-4lglA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 TYR A 209
LEU A 136
PRO A 343
LEU A 364
 None
 1.48A 5eshA-4mguA:
undetectable		 5eshA-4mguA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		4 TYR A  61
LEU A 133
PRO A  84
LEU A  92
 None
 1.03A 5eshA-4qlbA:
undetectable		 5eshA-4qlbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		4 TYR A 328
LEU A 495
PRO A 497
LEU A 372
 None
 1.25A 5eshA-4r1zA:
33.1		 5eshA-4r1zA:
25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 TYR A  72
LEU A 129
PRO A 238
LEU A 383
 None
None
None
HEM  A 601 (-4.0A)
 0.88A 5eshA-5hs1A:
63.7		 5eshA-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG
STRIGOLACTONE
ESTERASE D14

(Arabidopsis
thaliana;
Oryza sativa) 		PF12697
(Abhydrolase_6)
no annotation 		4 TRP A 155
LEU A 162
PRO A 161
LEU B 615
 None
 1.31A 5eshA-5hzgA:
undetectable		 5eshA-5hzgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		4 TYR A 590
LEU A 572
PRO A 583
LEU A 565
 None
 1.41A 5eshA-5l44A:
undetectable		 5eshA-5l44A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv9 BOR1P BORON
TRANSPORTER

(Saccharomyces
mikatae) 		PF00955
(HCO3_cotransp) 		4 TYR A  55
LEU A 412
PRO A  61
LEU A 404
 None
 1.08A 5eshA-5sv9A:
undetectable		 5eshA-5sv9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		4 TYR A 360
TRP A 405
LEU A 202
LEU A 414
 None
 1.43A 5eshA-5thwA:
undetectable		 5eshA-5thwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 TYR A  79
LEU A 287
PRO A 207
LEU A 213
 None
 1.24A 5eshA-5ubkA:
undetectable		 5eshA-5ubkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled) 		4 TYR A 394
LEU A 515
PRO A 513
LEU A 522
 836  A1201 (-4.6A)
None
836  A1201 (-4.1A)
836  A1201 (-4.6A)
 1.47A 5eshA-5v57A:
1.0		 5eshA-5v57A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhj CYTOCHROME P450

(Exiguobacterium
sp. AT1b) 		no annotation 4 TYR A 382
LEU A 389
PRO A 385
LEU A 249
 None
 1.35A 5eshA-5yhjA:
27.3		 5eshA-5yhjA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 TRP A 696
LEU A 291
PRO A 289
LEU A 376
 None
 1.19A 5eshA-6etzA:
undetectable		 5eshA-6etzA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g8r NUCLEAR BODY PROTEIN
SP140
SHORT-CHAIN VARIABLE
FRAGMENT

(Homo sapiens) 		no annotation 4 TYR B 786
LEU A 114
PRO A  41
LEU A  86
 None
 1.44A 5eshA-6g8rB:
undetectable		 5eshA-6g8rB:
11.86