SIMILAR PATTERNS OF AMINO ACIDS FOR 5ESH_A_1YNA602
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fbv | SIGNAL TRANSDUCTIONPROTEIN CBL (Homo sapiens) |
PF02262(Cbl_N)PF02761(Cbl_N2)PF02762(Cbl_N3)PF14447(Prok-RING_4) | 5 | LEU A 88PHE A 115GLY A 110THR A 50MET A 119 | None | 1.04A | 5eshA-1fbvA:0.1 | 5eshA-1fbvA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hw2 | FATTY ACIDMETABOLISM REGULATORPROTEIN (Escherichiacoli) |
PF00392(GntR)PF07840(FadR_C) | 5 | ALA A 87LEU A 97PHE A 112ILE A 113GLY A 151 | None | 1.16A | 5eshA-1hw2A:0.0 | 5eshA-1hw2A:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 5 | ALA A 735ILE A 81TYR A 8THR A 637LEU A 663 | None | 1.18A | 5eshA-1j1wA:undetectable | 5eshA-1j1wA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqo | PHOSPHOENOLPYRUVATECARBOXYLASE (Zea mays) |
PF00311(PEPcase) | 5 | LEU A 46ILE A 956GLY A 950LEU A 938PHE A 225 | None | 1.16A | 5eshA-1jqoA:undetectable | 5eshA-1jqoA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pho | PHOSPHOPORIN (Escherichiacoli) |
PF00267(Porin_1) | 5 | ALA A 261LEU A 273ILE A 326GLY A 280THR A 254 | None | 1.10A | 5eshA-1phoA:undetectable | 5eshA-1phoA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgq | STREPTOMYCES GRISEUSPROTEINASE B (Streptomycesgriseus) |
PF00089(Trypsin) | 5 | ALA E 192ILE E 113PHE E 52GLY E 86THR E 65 | None | 1.19A | 5eshA-1sgqE:undetectable | 5eshA-1sgqE:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t0b | THUA-LIKE PROTEIN (Geobacillusstearothermophilus) |
PF06283(ThuA) | 5 | ALA A 48LEU A 57PHE A 185ILE A 161GLY A 182 | None | 1.19A | 5eshA-1t0bA:undetectable | 5eshA-1t0bA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tis | THYMIDYLATE SYNTHASE (Escherichiavirus T4) |
PF00303(Thymidylat_synt) | 5 | ALA A 54ILE A 210GLY A 213THR A 216LEU A 184 | None | 1.08A | 5eshA-1tisA:undetectable | 5eshA-1tisA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tuo | PUTATIVEPHOSPHOMANNOMUTASE (Thermusthermophilus) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | ALA A 188PHE A 14ILE A 12PHE A 120LEU A 68 | None | 1.10A | 5eshA-1tuoA:undetectable | 5eshA-1tuoA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x8v | CYTOCHROME P450 51 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | LEU A 19TYR A 76PHE A 83THR A 260LEU A 321 | NoneESL A 471 ( 3.8A)NoneHEM A 470 (-3.6A)HEM A 470 (-4.1A) | 1.04A | 5eshA-1x8vA:34.7 | 5eshA-1x8vA:28.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xpg | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 5 | ALA A 210PHE A 185ILE A 196THR A 70PHE A 203 | None | 1.20A | 5eshA-1xpgA:undetectable | 5eshA-1xpgA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bfr | HYPOTHETICAL PROTEINAF1521 (Archaeoglobusfulgidus) |
PF01661(Macro) | 5 | ALA A 127ILE A 144TYR A 145GLY A 40THR A 59 | NoneADP A1193 (-3.7A)ADP A1193 (-3.4A)NoneNone | 1.10A | 5eshA-2bfrA:undetectable | 5eshA-2bfrA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dgk | GLUTAMATEDECARBOXYLASE BETA (Escherichiacoli) |
PF00282(Pyridoxal_deC) | 5 | ALA A 136LEU A 295PHE A 331GLY A 278PHE A 262 | None | 1.15A | 5eshA-2dgkA:undetectable | 5eshA-2dgkA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dph | FORMALDEHYDEDISMUTASE (Pseudomonasputida) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 202PHE A 126ILE A 51GLY A 65THR A 42 | None | 1.21A | 5eshA-2dphA:undetectable | 5eshA-2dphA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw6 | BLL6730 PROTEIN (Bradyrhizobiumjaponicum) |
PF13378(MR_MLE_C) | 5 | ALA A 125LEU A 132ILE A 15TYR A 350GLY A 59 | None | 1.20A | 5eshA-2dw6A:undetectable | 5eshA-2dw6A:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eae | ALPHA-FUCOSIDASE (Bifidobacteriumbifidum) |
PF14498(Glyco_hyd_65N_2) | 5 | ALA A 321TYR A 380PHE A 769TYR A 377GLY A 398 | None | 1.22A | 5eshA-2eaeA:undetectable | 5eshA-2eaeA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gzo | UPF0301 PROTEINSO3346 (Shewanellaoneidensis) |
PF02622(DUF179) | 5 | ALA A 35LEU A 27GLY A 45LEU A 128PHE A 84 | None | 1.14A | 5eshA-2gzoA:undetectable | 5eshA-2gzoA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i3f | GLYCOLIPIDTRANSFER-LIKEPROTEIN (Galdieriasulphuraria) |
PF08718(GLTP) | 5 | ALA A 70LEU A 82GLY A 202THR A 132PHE A 35 | None | 1.17A | 5eshA-2i3fA:undetectable | 5eshA-2i3fA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inv | INSULINFRUCTOTRANSFERASE (Bacillus sp.snu-7) |
no annotation | 5 | ALA A 276LEU A 274PHE A 183ILE A 153PHE A 180 | None | 1.04A | 5eshA-2invA:undetectable | 5eshA-2invA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pm9 | PROTEIN TRANSPORTPROTEIN SEC31 (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | ALA A 5LEU A 47ILE A 76GLY A 79LEU A 42 | None | 1.23A | 5eshA-2pm9A:undetectable | 5eshA-2pm9A:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pvz | PRPF METHYLACONITATEISOMERASE (Shewanellaoneidensis) |
PF04303(PrpF) | 5 | ALA A 113LEU A 110PHE A 226ILE A 218PHE A 181 | None | 1.19A | 5eshA-2pvzA:undetectable | 5eshA-2pvzA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjv | UNCHARACTERIZEDIOLB-LIKE PROTEIN (Salmonellaenterica) |
PF04962(KduI) | 5 | ALA A 94LEU A 88TYR A 84ILE A 81LEU A 58 | MLY A 95 ( 3.3A)NoneNoneNoneNone | 1.23A | 5eshA-2qjvA:undetectable | 5eshA-2qjvA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzw | CANDIDAPEPSIN-1 (Candidaalbicans) |
PF00026(Asp) | 5 | ALA A 177TYR A 14ILE A 30GLY A 34LEU A 311 | None | 1.09A | 5eshA-2qzwA:undetectable | 5eshA-2qzwA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzx | CANDIDAPEPSIN-5 (Candidaalbicans) |
PF00026(Asp) | 5 | ALA A 177TYR A 14ILE A 30GLY A 34LEU A 311 | None | 1.16A | 5eshA-2qzxA:undetectable | 5eshA-2qzxA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x3n | PROBABLEFAD-DEPENDENTMONOOXYGENASE (Pseudomonasaeruginosa) |
PF01494(FAD_binding_3) | 5 | LEU A 358PHE A 190PHE A 269GLY A 265PHE A 251 | None | 1.19A | 5eshA-2x3nA:undetectable | 5eshA-2x3nA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yn9 | POTASSIUM-TRANSPORTING ATPASE ALPHACHAIN 1 (Sus scrofa) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF09040(H-K_ATPase_N)PF13246(Cation_ATPase) | 5 | ALA A 440LEU A 466ILE A 406GLY A 555PHE A 564 | None | 1.20A | 5eshA-2yn9A:undetectable | 5eshA-2yn9A:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aeu | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Rhodobactercapsulatus) |
PF00148(Oxidored_nitro) | 5 | ALA A 310LEU A 341GLY A 231THR A 229LEU A 221 | None | 1.22A | 5eshA-3aeuA:undetectable | 5eshA-3aeuA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bcz | PROTEIN MEMO1 (Homo sapiens) |
PF01875(Memo) | 5 | LEU A 157PHE A 270PHE A 190GLY A 220LEU A 236 | None | 1.24A | 5eshA-3bczA:undetectable | 5eshA-3bczA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bq9 | PREDICTED ROSSMANNFOLDNUCLEOTIDE-BINDINGDOMAIN-CONTAININGPROTEIN (Idiomarinabaltica) |
PF03641(Lysine_decarbox)PF11892(DUF3412)PF14793(DUF4478) | 5 | ALA A 307LEU A 310ILE A 177PHE A 241GLY A 180 | None | 1.24A | 5eshA-3bq9A:undetectable | 5eshA-3bq9A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bu1 | LIPOCALIN (Argasmonolakensis) |
PF02098(His_binding) | 5 | ALA A 49LEU A 13TYR A 22TYR A 138LEU A 62 | None | 1.18A | 5eshA-3bu1A:undetectable | 5eshA-3bu1A:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxj | RASGTPASE-ACTIVATINGPROTEIN SYNGAP (Rattusnorvegicus) |
PF00168(C2)PF00616(RasGAP) | 5 | ALA A 679LEU A 680ILE A 486TYR A 482GLY A 666 | None | 1.23A | 5eshA-3bxjA:undetectable | 5eshA-3bxjA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c7v | BETA-LACTAMASEINHIBITORY PROTEIN (Streptomycesclavuligerus) |
PF07467(BLIP) | 5 | ALA B 52LEU B 75PHE B 151GLY B 158PHE B 132 | None | 1.22A | 5eshA-3c7vB:undetectable | 5eshA-3c7vB:13.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwc | METALLOCARBOXYPEPTIDASE (Trypanosomacruzi) |
PF02074(Peptidase_M32) | 5 | LEU A 362ILE A 159TYR A 160PHE A 137THR A 107 | None | 1.06A | 5eshA-3dwcA:undetectable | 5eshA-3dwcA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwc | METALLOCARBOXYPEPTIDASE (Trypanosomacruzi) |
PF02074(Peptidase_M32) | 5 | LEU A 362TYR A 417ILE A 159TYR A 160THR A 107 | None | 1.23A | 5eshA-3dwcA:undetectable | 5eshA-3dwcA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fv3 | SAPP1P-SECRETEDASPARTIC PROTEASE 1 (Candidaparapsilosis) |
PF00026(Asp) | 5 | ALA A 180TYR A 14ILE A 30GLY A 34LEU A 309 | None | 1.16A | 5eshA-3fv3A:undetectable | 5eshA-3fv3A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gnq | GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE, TYPEI (Burkholderiapseudomallei) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ALA A 233ILE A 262PHE A 248GLY A 171LEU A 225 | None | 1.20A | 5eshA-3gnqA:undetectable | 5eshA-3gnqA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h8f | CYTOSOLAMINOPEPTIDASE (Pseudomonasputida) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 5 | LEU A 313PHE A 234ILE A 226THR A 270LEU A 202 | None | 1.15A | 5eshA-3h8fA:undetectable | 5eshA-3h8fA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibp | CHROMOSOME PARTITIONPROTEIN MUKB (Escherichiacoli) |
PF16330(MukB_hinge) | 5 | ALA A 763ILE A 689TYR A 690GLY A 739PHE A 749 | None | 1.22A | 5eshA-3ibpA:undetectable | 5eshA-3ibpA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksm | ABC-TYPE SUGARTRANSPORT SYSTEM,PERIPLASMICCOMPONENT (Hahellachejuensis) |
PF13407(Peripla_BP_4) | 5 | ALA A 267LEU A 241PHE A 187LEU A 160PHE A 253 | None | 1.21A | 5eshA-3ksmA:undetectable | 5eshA-3ksmA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 5 | TYR A 102TYR A 115PHE A 289THR A 294LEU A 355 | HEM A 481 (-4.7A)HEM A 481 ( 4.9A)TPF A 490 (-4.3A)TPF A 490 ( 3.5A)TPF A 490 (-4.4A) | 1.04A | 5eshA-3l4dA:38.7 | 5eshA-3l4dA:29.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 5 | TYR A 102TYR A 115THR A 294LEU A 355MET A 459 | HEM A 481 (-4.7A)HEM A 481 ( 4.9A)TPF A 490 ( 3.5A)TPF A 490 (-4.4A)TPF A 490 (-4.7A) | 0.66A | 5eshA-3l4dA:38.7 | 5eshA-3l4dA:29.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lot | UNCHARACTERIZEDPROTEIN (Archaeoglobusfulgidus) |
PF05853(BKACE) | 5 | ALA A 100LEU A 159ILE A 208GLY A 237PHE A 149 | NoneNoneNoneNoneUNL A 504 ( 4.6A) | 1.02A | 5eshA-3lotA:undetectable | 5eshA-3lotA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpp | SUCRASE-ISOMALTASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 5 | ALA A 606PHE A 589ILE A 594GLY A 243THR A 229 | None | 1.21A | 5eshA-3lppA:undetectable | 5eshA-3lppA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1t | PUTATIVEPHOSPHOHYDROLASE (Shewanellaamazonensis) |
PF08668(HDOD) | 5 | LEU A 143PHE A 131ILE A 114LEU A 273PHE A 105 | None | 1.02A | 5eshA-3m1tA:undetectable | 5eshA-3m1tA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n23 | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 (Sus scrofa) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 5 | ALA A 424LEU A 450ILE A 390GLY A 539PHE A 548 | None | 1.23A | 5eshA-3n23A:undetectable | 5eshA-3n23A:19.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n5m | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE (Bacillusanthracis) |
PF00202(Aminotran_3) | 5 | ALA A 324LEU A 290ILE A 221GLY A 262LEU A 428 | None | 1.08A | 5eshA-3n5mA:undetectable | 5eshA-3n5mA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwr | DNA REPAIR PROTEINXRCC4 (Homo sapiens) |
PF06632(XRCC4) | 5 | ALA A 56ILE A 5PHE A 86LEU A 113PHE A 32 | None | 1.00A | 5eshA-3rwrA:undetectable | 5eshA-3rwrA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s51 | FANCONI ANEMIA GROUPI PROTEIN HOMOLOG (Mus musculus) |
PF14674(FANCI_S1-cap)PF14675(FANCI_S1)PF14676(FANCI_S2)PF14677(FANCI_S3)PF14678(FANCI_S4)PF14679(FANCI_HD1)PF14680(FANCI_HD2) | 5 | LEU A 930TYR A 884ILE A 903LEU A 980PHE A 958 | None | 1.21A | 5eshA-3s51A:undetectable | 5eshA-3s51A:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfz | LACTO-N-BIOSEPHOSPHORYLASE (Bifidobacteriumlongum) |
PF09508(Lact_bio_phlase)PF17385(LBP_M)PF17386(LBP_C) | 5 | ALA A 407LEU A 22ILE A 426GLY A 745LEU A 379 | None | 1.12A | 5eshA-3wfzA:undetectable | 5eshA-3wfzA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zhb | R-IMINE REDUCTASE (Streptomyceskanamyceticus) |
PF03446(NAD_binding_2) | 5 | ALA A 88LEU A 92PHE A 38GLY A 167THR A 173 | NAP A1307 (-3.6A)NAP A1307 (-4.5A)NoneNoneNone | 1.16A | 5eshA-3zhbA:undetectable | 5eshA-3zhbA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aee | ALPHA AMYLASE,CATALYTIC REGION (Staphylothermusmarinus) |
PF00128(Alpha-amylase) | 5 | LEU A 597ILE A 271PHE A 236GLY A 266MET A 586 | None | 1.20A | 5eshA-4aeeA:undetectable | 5eshA-4aeeA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b9y | ALPHA-GLUCOSIDASE,PUTATIVE, ADG31B (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF17137(DUF5110) | 5 | ALA A 577LEU A 588ILE A 154LEU A 245PHE A 594 | None | 1.21A | 5eshA-4b9yA:undetectable | 5eshA-4b9yA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bzk | PROTEIN TRANSPORTPROTEIN SEC31 (Saccharomycescerevisiae) |
PF00400(WD40)PF12931(Sec16_C) | 5 | ALA A 5LEU A 47ILE A 76GLY A 79LEU A 42 | None | 1.23A | 5eshA-4bzkA:undetectable | 5eshA-4bzkA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3e | MAOC DOMAIN PROTEINDEHYDRATASE (Chloroflexusaurantiacus) |
PF01575(MaoC_dehydratas) | 5 | LEU A 115PHE A 70ILE A 275PHE A 74GLY A 252 | None | 1.06A | 5eshA-4e3eA:undetectable | 5eshA-4e3eA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6w | N-TERMINALCYANOBACTIN PROTEASE (Planktothrixagardhii) |
PF00082(Peptidase_S8) | 5 | ALA A 132LEU A 168ILE A 68GLY A 62LEU A 97 | None | 1.16A | 5eshA-4h6wA:undetectable | 5eshA-4h6wA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3f | SERINE HYDROLASECCSP0084 (Cycloclasticussp. P1) |
PF12697(Abhydrolase_6) | 5 | PHE A 63ILE A 60PHE A 193GLY A 33LEU A 140 | NoneNoneNone CL A 301 (-4.0A)None | 1.20A | 5eshA-4i3fA:undetectable | 5eshA-4i3fA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlw | GLUTATHIONE-INDEPENDENT FORMALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 195LEU A 200TYR A 344PHE A 94GLY A 110 | NoneNoneNoneNAD A 403 (-4.6A)None | 1.12A | 5eshA-4jlwA:undetectable | 5eshA-4jlwA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jre | NITRITE EXTRUSIONPROTEIN 1 (Escherichiacoli) |
PF07690(MFS_1) | 5 | ALA A 307LEU A 311ILE A 447GLY A 333LEU A 358 | None | 1.15A | 5eshA-4jreA:undetectable | 5eshA-4jreA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4npc | SORBITOLDEHYDROGENASE (Brucella suis) |
PF13561(adh_short_C2) | 5 | ALA A 44LEU A 46ILE A 171GLY A 245LEU A 235 | None | 0.91A | 5eshA-4npcA:undetectable | 5eshA-4npcA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o0l | NADPH-DEPENDENT3-QUINUCLIDINONEREDUCTASE (Rhodotorulamucilaginosa) |
PF13561(adh_short_C2) | 5 | ALA A 56LEU A 58GLY A 260THR A 258LEU A 250 | None | 0.98A | 5eshA-4o0lA:undetectable | 5eshA-4o0lA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ojz | PUTATIVE ALGINATELYASE (Saccharophagusdegradans) |
PF05426(Alginate_lyase)PF07940(Hepar_II_III) | 5 | ALA A 80TYR A 122PHE A 181ILE A 176GLY A 160 | None | 1.18A | 5eshA-4ojzA:undetectable | 5eshA-4ojzA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pju | COHESIN SUBUNIT SA-2 (Homo sapiens) |
PF08514(STAG) | 5 | ALA A 857PHE A 768ILE A 771TYR A 775THR A 695 | None | 1.17A | 5eshA-4pjuA:undetectable | 5eshA-4pjuA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q8k | ALGINASE (Pseudoalteromonassp. SM0524) |
PF08787(Alginate_lyase2) | 5 | ALA A 208PHE A 289GLY A 287PHE A 378MET A 247 | None | 1.20A | 5eshA-4q8kA:undetectable | 5eshA-4q8kA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q8l | ALGINASE (Pseudoalteromonassp. SM0524) |
PF08787(Alginate_lyase2) | 5 | ALA A 41PHE A 122GLY A 120PHE A 211MET A 80 | None | 1.19A | 5eshA-4q8lA:undetectable | 5eshA-4q8lA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv2 | MAOC FAMILY PROTEINUPF0336 PROTEINMSMEG_1340/MSMEI_1302 (Mycolicibacteriumsmegmatis) |
PF01575(MaoC_dehydratas)PF13452(MaoC_dehydrat_N) | 5 | LEU B 52PHE B 104ILE B 20GLY B 67THR A 58 | None | 1.01A | 5eshA-4rv2B:undetectable | 5eshA-4rv2B:13.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvc | ABC TRANSPORTERATP-BINDING PROTEIN (Geobacilluskaustophilus) |
PF00005(ABC_tran) | 5 | LEU A 91PHE A 78ILE A 157TYR A 80GLY A 51 | None | 0.97A | 5eshA-4rvcA:undetectable | 5eshA-4rvcA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rz2 | SITE-DETERMININGPROTEIN (Geobacillusthermodenitrificans) |
PF10609(ParA) | 5 | PHE A 284ILE A 119PHE A 151THR A 106LEU A 78 | None | 1.17A | 5eshA-4rz2A:undetectable | 5eshA-4rz2A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xz3 | ACYL-COA SYNTHETASE(NDP FORMING) (CandidatusKorarchaeumcryptofilum) |
PF13380(CoA_binding_2)PF13607(Succ_CoA_lig) | 5 | LEU A 196TYR A 133ILE A 98GLY A 145PHE A 8 | NoneNoneCOA A 501 (-4.1A)NoneNone | 1.23A | 5eshA-4xz3A:undetectable | 5eshA-4xz3A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z5q | CYTOCHROME P450HYDROXYLASE (Streptomycesatroolivaceus) |
PF00067(p450) | 5 | ALA A 276LEU A 280ILE A 239LEU A 357PHE A 345 | NoneNoneP33 A 407 ( 4.5A)HEM A 401 (-4.6A)HEM A 401 (-4.6A) | 1.15A | 5eshA-4z5qA:25.2 | 5eshA-4z5qA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zze | SUGAR BINDINGPROTEIN OF ABCTRANSPORTER SYSTEM (Bifidobacteriumanimalis) |
PF01547(SBP_bac_1) | 5 | ALA A 312LEU A 225TYR A 171PHE A 200MET A 196 | None | 1.10A | 5eshA-4zzeA:1.3 | 5eshA-4zzeA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a55 | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 5 | ALA A1081LEU A1093TYR A 873GLY A1015THR A1017 | None | 1.23A | 5eshA-5a55A:undetectable | 5eshA-5a55A:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aw4 | NA, K-ATPASE ALPHASUBUNIT (Squalusacanthias) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 5 | ALA A 431LEU A 457ILE A 397GLY A 546PHE A 555 | None | 1.18A | 5eshA-5aw4A:undetectable | 5eshA-5aw4A:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d6o | HOMOSERINEO-ACETYLTRANSFERASE (Corynebacteriumglutamicum) |
PF00561(Abhydrolase_1) | 5 | ALA A 166LEU A 328GLY A 206THR A 185LEU A 213 | NoneGOL A 407 ( 4.8A)NoneNoneNone | 1.18A | 5eshA-5d6oA:undetectable | 5eshA-5d6oA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7s | LON PROTEASE (Meiothermustaiwanensis) |
PF05362(Lon_C) | 5 | ALA A 688LEU A 766GLY A 607THR A 603LEU A 610 | None | 1.08A | 5eshA-5e7sA:undetectable | 5eshA-5e7sA:19.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fsa | CYP51 VARIANT1 (Candidaalbicans) |
PF00067(p450) | 8 | ALA A 61LEU A 87PHE A 126ILE A 131TYR A 132PHE A 228GLY A 307MET A 508 | X2N A 590 (-3.5A)NoneX2N A 590 (-4.8A)X2N A 590 (-4.2A)HEM A 580 (-4.1A)X2N A 590 (-4.9A)X2N A 590 (-3.5A)X2N A 590 (-4.8A) | 1.32A | 5eshA-5fsaA:57.7 | 5eshA-5fsaA:59.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fsa | CYP51 VARIANT1 (Candidaalbicans) |
PF00067(p450) | 12 | ALA A 61LEU A 88TYR A 118PHE A 126ILE A 131TYR A 132PHE A 228GLY A 307THR A 311LEU A 376PHE A 380MET A 508 | X2N A 590 (-3.5A)NoneX2N A 590 ( 4.0A)X2N A 590 (-4.8A)X2N A 590 (-4.2A)HEM A 580 (-4.1A)X2N A 590 (-4.9A)X2N A 590 (-3.5A)HEM A 580 (-3.6A)X2N A 590 (-4.3A)X2N A 590 ( 4.8A)X2N A 590 (-4.8A) | 0.75A | 5eshA-5fsaA:57.7 | 5eshA-5fsaA:59.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gsl | 778AA LONGHYPOTHETICALBETA-GALACTOSIDASE (Pyrococcushorikoshii) |
PF02449(Glyco_hydro_42) | 5 | LEU A 280TYR A 337ILE A 492TYR A 336PHE A 329 | None | 1.23A | 5eshA-5gslA:undetectable | 5eshA-5gslA:22.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hj7 | GLUTAMATE RACEMASE (Mycobacteriumtuberculosis) |
PF01177(Asp_Glu_race) | 5 | ALA A 246ILE A 195GLY A 118THR A 122PHE A 254 | None | 1.14A | 5eshA-5hj7A:undetectable | 5eshA-5hj7A:19.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hs1 | LANOSTEROL 14-ALPHADEMETHYLASE (Saccharomycescerevisiae) |
PF00067(p450) | 5 | ALA A 69LEU A 96ILE A 139TYR A 140LEU A 383 | NoneNoneVOR A 602 (-4.3A)HEM A 601 (-4.3A)HEM A 601 (-4.0A) | 1.10A | 5eshA-5hs1A:63.7 | 5eshA-5hs1A:99.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hs1 | LANOSTEROL 14-ALPHADEMETHYLASE (Saccharomycescerevisiae) |
PF00067(p450) | 11 | ALA A 69LEU A 96TYR A 126PHE A 134ILE A 139TYR A 140PHE A 236GLY A 314THR A 318LEU A 380PHE A 384 | NoneNoneVOR A 602 ( 3.8A)VOR A 602 (-4.7A)VOR A 602 (-4.3A)HEM A 601 (-4.3A)VOR A 602 (-4.4A)VOR A 602 (-3.0A)HEM A 601 (-3.4A)VOR A 602 (-4.0A)None | 0.59A | 5eshA-5hs1A:63.7 | 5eshA-5hs1A:99.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hs1 | LANOSTEROL 14-ALPHADEMETHYLASE (Saccharomycescerevisiae) |
PF00067(p450) | 5 | TYR A 126TYR A 140THR A 318LEU A 380MET A 509 | VOR A 602 ( 3.8A)HEM A 601 (-4.3A)HEM A 601 (-3.4A)VOR A 602 (-4.0A)VOR A 602 ( 4.2A) | 1.02A | 5eshA-5hs1A:63.7 | 5eshA-5hs1A:99.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jlc | LANOSTEROL 14-ALPHADEMETHYLASE ([Candida]glabrata) |
PF00067(p450) | 8 | ALA A 70LEU A 96PHE A 135ILE A 140TYR A 141PHE A 237GLY A 315MET A 512 | 1YN A 602 (-3.4A)None1YN A 602 ( 4.6A)1YN A 602 (-4.4A)HEM A 601 (-4.2A)1YN A 602 (-4.5A)1YN A 602 ( 3.6A)1YN A 602 (-3.5A) | 1.44A | 5eshA-5jlcA:59.1 | 5eshA-5jlcA:83.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jlc | LANOSTEROL 14-ALPHADEMETHYLASE ([Candida]glabrata) |
PF00067(p450) | 8 | ALA A 70LEU A 97PHE A 237GLY A 315THR A 319LEU A 381PHE A 385MET A 512 | 1YN A 602 (-3.4A)None1YN A 602 (-4.5A)1YN A 602 ( 3.6A)HEM A 601 ( 3.5A)1YN A 602 ( 4.7A)1YN A 602 (-4.8A)1YN A 602 (-3.5A) | 0.83A | 5eshA-5jlcA:59.1 | 5eshA-5jlcA:83.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jlc | LANOSTEROL 14-ALPHADEMETHYLASE ([Candida]glabrata) |
PF00067(p450) | 11 | ALA A 70LEU A 97TYR A 127PHE A 135ILE A 140TYR A 141PHE A 237GLY A 315THR A 319LEU A 381MET A 512 | 1YN A 602 (-3.4A)None1YN A 602 ( 3.8A)1YN A 602 ( 4.6A)1YN A 602 (-4.4A)HEM A 601 (-4.2A)1YN A 602 (-4.5A)1YN A 602 ( 3.6A)HEM A 601 ( 3.5A)1YN A 602 ( 4.7A)1YN A 602 (-3.5A) | 0.73A | 5eshA-5jlcA:59.1 | 5eshA-5jlcA:83.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jmd | HEPARINASE IIIPROTEIN (Bacteroidesthetaiotaomicron) |
PF07940(Hepar_II_III)PF16889(Hepar_II_III_N) | 6 | LEU A 575ILE A 343GLY A 405THR A 493LEU A 505PHE A 529 | None | 1.34A | 5eshA-5jmdA:undetectable | 5eshA-5jmdA:22.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kvu | ISOCITRATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF03971(IDH) | 5 | ALA A 738ILE A 83TYR A 10GLY A 614LEU A 666 | None | 1.16A | 5eshA-5kvuA:undetectable | 5eshA-5kvuA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kvu | ISOCITRATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF03971(IDH) | 5 | ALA A 742ILE A 83TYR A 10GLY A 614LEU A 666 | None | 1.12A | 5eshA-5kvuA:undetectable | 5eshA-5kvuA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l56 | PLEXIN-A1 (Mus musculus) |
PF01403(Sema)PF01437(PSI)PF01833(TIG) | 5 | ALA A1104LEU A1064GLY A 969THR A 975MET A1128 | None | 0.86A | 5eshA-5l56A:undetectable | 5eshA-5l56A:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrw | POTASSIUM-TRANSPORTING ATPASEATP-BINDING SUBUNITPOTASSIUM-TRANSPORTING ATPASEPOTASSIUM-BINDINGSUBUNIT (Escherichiacoli) |
PF00122(E1-E2_ATPase)PF00702(Hydrolase)PF03814(KdpA) | 5 | ALA B 67LEU B 618ILE A 544TYR B 587PHE B 595 | None | 1.05A | 5eshA-5mrwB:undetectable | 5eshA-5mrwB:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrw | POTASSIUM-TRANSPORTING ATPASEPOTASSIUM-BINDINGSUBUNIT (Escherichiacoli) |
PF03814(KdpA) | 5 | ALA A 265TYR A 404ILE A 409THR A 534LEU A 531 | None | 1.20A | 5eshA-5mrwA:undetectable | 5eshA-5mrwA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5svc | ACETONE CARBOXYLASEALPHA SUBUNIT (Xanthobacterautotrophicus) |
PF02538(Hydantoinase_B) | 5 | ALA A 259LEU A 49TYR A 41TYR A 376GLY A 116 | None | 1.10A | 5eshA-5svcA:undetectable | 5eshA-5svcA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ua2 | HTH-TYPETRANSCRIPTIONALREPRESSOR KSTR (Mycobacteriumtuberculosis) |
no annotation | 5 | LEU A 85PHE A 161ILE A 181GLY A 119MET A 125 | None | 1.20A | 5eshA-5ua2A:2.4 | 5eshA-5ua2A:10.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vx6 | UNCHARACTERIZEDPROTEIN YPFA (Bacillussubtilis) |
no annotation | 5 | ALA A 138LEU A 141ILE A 191TYR A 188LEU A 109 | None | 1.05A | 5eshA-5vx6A:undetectable | 5eshA-5vx6A:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w19 | TRYPTOPHANASE (Proteusvulgaris) |
no annotation | 5 | ALA A 137LEU A 456ILE A 417PHE A 356GLY A 351 | None | 1.14A | 5eshA-5w19A:undetectable | 5eshA-5w19A:10.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wu7 | UNCHARACTERIZEDPROTEIN (Pyrococcushorikoshii) |
PF03065(Glyco_hydro_57)PF09210(DUF1957) | 5 | ALA A 158LEU A 461ILE A 73THR A 11PHE A 525 | None | 1.15A | 5eshA-5wu7A:undetectable | 5eshA-5wu7A:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x5h | CYSTATHIONINEBETA-LYASES/CYSTATHIONINEGAMMA-SYNTHASES (Corynebacteriumglutamicum) |
PF01053(Cys_Met_Meta_PP) | 5 | ALA A 68ILE A 369GLY A 304LEU A 187PHE A 10 | None | 1.22A | 5eshA-5x5hA:undetectable | 5eshA-5x5hA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x5h | CYSTATHIONINEBETA-LYASES/CYSTATHIONINEGAMMA-SYNTHASES (Corynebacteriumglutamicum) |
PF01053(Cys_Met_Meta_PP) | 5 | ALA A 73ILE A 369GLY A 304LEU A 187PHE A 10 | None | 1.20A | 5eshA-5x5hA:undetectable | 5eshA-5x5hA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yg7 | RIBOSE1,5-BISPHOSPHATEISOMERASE (Pyrococcushorikoshii) |
no annotation | 6 | ALA A 34LEU A 61TYR A 239ILE A 206GLY A 202PHE A 106 | NoneNoneNoneNoneRI2 A 401 ( 3.9A)None | 1.38A | 5eshA-5yg7A:undetectable | 5eshA-5yg7A:9.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6ay4 | CYP51, STEROL14ALPHA-DEMETHYLASE (Naegleriafowleri) |
no annotation | 5 | TYR A 107TYR A 120PHE A 292THR A 297LEU A 358 | TPF A 506 (-4.2A)NoneTPF A 506 ( 4.0A)HEM A 501 (-3.4A)TPF A 506 ( 4.4A) | 1.16A | 5eshA-6ay4A:42.2 | 5eshA-6ay4A:33.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eq8 | PERIPLASMICALPHA-GALACTOSIDE-BINDING PROTEIN (Agrobacteriumtumefaciens) |
no annotation | 5 | ALA D 452ILE D 420GLY D 611LEU D 607PHE D 9 | None | 1.20A | 5eshA-6eq8D:undetectable | 5eshA-6eq8D:9.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ey1 | ANTITERMINATIONFACTOR NUSB (Escherichiacoli) |
PF01029(NusB) | 4 | TYR A 69LEU A 92PRO A 132LEU A 62 | None | 1.40A | 5eshA-1ey1A:undetectable | 5eshA-1ey1A:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pg7 | HUMANIZED ANTIBODYD3H44 (Homo sapiens;Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 176LEU H 108PRO H 41LEU H 11 | None | 1.41A | 5eshA-1pg7H:undetectable | 5eshA-1pg7H:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pu7 | 3-METHYLADENINE DNAGLYCOSYLASE (Helicobacterpylori) |
PF00633(HHH)PF00730(HhH-GPD) | 4 | TYR A 140LEU A 17PRO A 21LEU A 198 | NoneKCX A 205 ( 4.1A)NoneNone | 1.47A | 5eshA-1pu7A:0.0 | 5eshA-1pu7A:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pyf | IOLS PROTEIN (Bacillussubtilis) |
PF00248(Aldo_ket_red) | 4 | TYR A 267LEU A 248PRO A 260LEU A 181 | None | 1.49A | 5eshA-1pyfA:undetectable | 5eshA-1pyfA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8i | DNA POLYMERASE II (Escherichiacoli) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | TRP A 12LEU A 115PRO A 111LEU A 8 | None | 1.45A | 5eshA-1q8iA:0.3 | 5eshA-1q8iA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r76 | PECTATE LYASE (Niveispirillumirakense) |
PF09492(Pec_lyase) | 4 | TYR A 207TRP A 218PRO A 219LEU A 63 | None | 1.36A | 5eshA-1r76A:0.0 | 5eshA-1r76A:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to3 | PUTATIVE ALDOLASEYIHT (Salmonellaenterica) |
PF01791(DeoC) | 4 | TRP A 129LEU A 126PRO A 160LEU A 106 | None | 1.46A | 5eshA-1to3A:0.0 | 5eshA-1to3A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1up4 | 6-PHOSPHO-BETA-GLUCOSIDASE (Thermotogamaritima) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 4 | TYR A 187LEU A 242PRO A 240LEU A 190 | None | 1.46A | 5eshA-1up4A:0.0 | 5eshA-1up4A:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xcj | GUANIDINOACETATEN-METHYLTRANSFERASE (Rattusnorvegicus) |
no annotation | 4 | TYR A 221TRP A 143PRO A 137LEU A 33 | NMG A 237 ( 4.7A)NoneNoneNone | 1.49A | 5eshA-1xcjA:undetectable | 5eshA-1xcjA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bjq | MFP2A (Ascaris suum) |
PF12150(MFP2b) | 4 | TYR A 33TRP A 49LEU A 220LEU A 186 | None | 1.33A | 5eshA-2bjqA:0.0 | 5eshA-2bjqA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bws | XAA-PROAMINOPEPTIDASE P (Escherichiacoli) |
PF00557(Peptidase_M24)PF05195(AMP_N) | 4 | TYR A 51TRP A 50LEU A 184LEU A 174 | None | 1.38A | 5eshA-2bwsA:undetectable | 5eshA-2bwsA:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f5u | VIRION PROTEIN UL25 (Humanalphaherpesvirus1) |
PF01499(Herpes_UL25) | 4 | TYR A 562LEU A 147PRO A 145LEU A 411 | None | 1.47A | 5eshA-2f5uA:0.0 | 5eshA-2f5uA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6k | METAL-DEPENDENTHYDROLASE (Lactobacillusplantarum) |
PF04909(Amidohydro_2) | 4 | TRP A 30LEU A 11PRO A 33LEU A 54 | None | 1.29A | 5eshA-2f6kA:undetectable | 5eshA-2f6kA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hsz | NOVEL PREDICTEDPHOSPHATASE (Histophilussomni) |
PF13419(HAD_2) | 4 | TYR A 97LEU A 22PRO A 20LEU A 11 | NoneUNL A 227 (-4.8A)NoneNone | 1.46A | 5eshA-2hszA:undetectable | 5eshA-2hszA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kuc | PUTATIVEDISULPHIDE-ISOMERASE (Bacteroidesthetaiotaomicron) |
PF00085(Thioredoxin) | 4 | TRP A 35LEU A 42PRO A 38LEU A 100 | None | 1.00A | 5eshA-2kucA:undetectable | 5eshA-2kucA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4b | SIGMA-E FACTORREGULATORY PROTEINRSEB (Escherichiacoli) |
PF03888(MucB_RseB)PF17188(MucB_RseB_C) | 4 | TYR A 116LEU A 45PRO A 167LEU A 73 | None | 1.11A | 5eshA-2p4bA:undetectable | 5eshA-2p4bA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p6d | DIPHTHINE SYNTHASE (Pyrococcushorikoshii) |
PF00590(TP_methylase) | 4 | TYR A 220LEU A 242PRO A 239LEU A 261 | None | 1.29A | 5eshA-2p6dA:undetectable | 5eshA-2p6dA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qt3 | N-ISOPROPYLAMMELIDEISOPROPYLAMIDOHYDROLASE (Pseudomonas sp.ADP) |
PF01979(Amidohydro_1) | 4 | TRP A 251LEU A 328PRO A 283LEU A 292 | None | 1.48A | 5eshA-2qt3A:0.0 | 5eshA-2qt3A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v28 | PHENYLALANINE-4-HYDROXYLASE (Colwelliapsychrerythraea) |
PF00351(Biopterin_H) | 4 | TYR A 225TRP A 163LEU A 256LEU A 208 | None | 1.39A | 5eshA-2v28A:undetectable | 5eshA-2v28A:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vha | PERIPLASMIC BINDINGTRANSPORT PROTEIN (Shigellaflexneri) |
PF00497(SBP_bac_3) | 4 | TYR A 46TRP A 246LEU A 262LEU A 269 | None | 1.28A | 5eshA-2vhaA:undetectable | 5eshA-2vhaA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z7r | RIBOSOMAL PROTEIN S6KINASE ALPHA-1 (Homo sapiens) |
PF00069(Pkinase) | 4 | TYR A 228TRP A 246LEU A 168LEU A 153 | None | 1.22A | 5eshA-2z7rA:undetectable | 5eshA-2z7rA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zq5 | PUTATIVEUNCHARACTERIZEDPROTEIN (Mycobacteriumtuberculosis) |
PF13469(Sulfotransfer_3) | 4 | TYR A 82LEU A 124PRO A 132LEU A 74 | None | 1.27A | 5eshA-2zq5A:undetectable | 5eshA-2zq5A:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c0u | UNCHARACTERIZEDPROTEIN YAEQ (Escherichiacoli) |
PF07152(YaeQ) | 4 | TYR A 50TRP A 47LEU A 42LEU A 104 | None | 1.35A | 5eshA-3c0uA:undetectable | 5eshA-3c0uA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cbt | PHOSPHATASE SC4828 (Streptomycescoelicolor) |
PF04167(DUF402) | 4 | TRP A 130LEU A 58PRO A 204LEU A 138 | TRP A 130 (-0.5A)LEU A 58 ( 0.6A)PRO A 204 (-1.1A)LEU A 138 ( 0.6A) | 1.36A | 5eshA-3cbtA:undetectable | 5eshA-3cbtA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cv2 | MALATE SYNTHASE A (Escherichiacoli) |
PF01274(Malate_synthase) | 4 | TYR A 428LEU A 532PRO A 124LEU A 510 | None | 1.36A | 5eshA-3cv2A:2.1 | 5eshA-3cv2A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6u | VITAMIN K-DEPENDENTPROTEIN C HEAVYCHAIN (Homo sapiens) |
PF00089(Trypsin) | 4 | TRP H 29LEU H 212PRO H 198LEU H 106 | None | 1.09A | 5eshA-3f6uH:undetectable | 5eshA-3f6uH:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h41 | NLP/P60 FAMILYPROTEIN (Bacillus cereus) |
PF00877(NLPC_P60) | 4 | TRP A 41LEU A 127PRO A 123LEU A 88 | NoneNonePG4 A 3 ( 4.5A)None | 1.10A | 5eshA-3h41A:undetectable | 5eshA-3h41A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwg | ACETYLTRANSFERASE,GNAT FAMILY (Colwelliapsychrerythraea) |
PF00583(Acetyltransf_1) | 4 | TYR A 200LEU A 10PRO A 38LEU A 16 | None | 1.45A | 5eshA-3iwgA:undetectable | 5eshA-3iwgA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j0a | TOLL-LIKE RECEPTOR 5 (Homo sapiens) |
PF01582(TIR)PF13855(LRR_8) | 4 | TRP A 495LEU A 478PRO A 469LEU A 531 | None | 1.36A | 5eshA-3j0aA:undetectable | 5eshA-3j0aA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mi9 | CELL DIVISIONPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 4 | TYR A 194TRP A 213LEU A 133LEU A 114 | None | 1.38A | 5eshA-3mi9A:undetectable | 5eshA-3mi9A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ss7 | D-SERINE DEHYDRATASE (Escherichiacoli) |
PF00291(PALP) | 4 | TYR X 248TRP X 422LEU X 340PRO X 277 | NoneNoneNonePLP X 502 ( 4.8A) | 1.42A | 5eshA-3ss7X:0.6 | 5eshA-3ss7X:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uan | HEPARAN SULFATEGLUCOSAMINE3-O-SULFOTRANSFERASE1 (Mus musculus) |
PF00685(Sulfotransfer_1) | 4 | TYR A 192LEU A 165PRO A 176LEU A 158 | None | 1.43A | 5eshA-3uanA:undetectable | 5eshA-3uanA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bp8 | OLIGOPEPTIDASE B (Trypanosomabrucei) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 4 | TYR A 507LEU A 704PRO A 499LEU A 584 | None | 1.39A | 5eshA-4bp8A:undetectable | 5eshA-4bp8A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgl | GLYCINEDEHYDROGENASE[DECARBOXYLATING] (Synechocystissp. PCC 6803) |
PF02347(GDC-P) | 4 | TYR A 821LEU A 858PRO A 866LEU A 918 | None | 1.45A | 5eshA-4lglA:undetectable | 5eshA-4lglA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mgu | STRUCTURAL PROTEINVP2 (Orthopteranambidensovirus1) |
PF02336(Denso_VP4) | 4 | TYR A 209LEU A 136PRO A 343LEU A 364 | None | 1.48A | 5eshA-4mguA:undetectable | 5eshA-4mguA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlb | PROBABLE GLYCOGEN[STARCH] SYNTHASE (Caenorhabditiselegans) |
PF05693(Glycogen_syn) | 4 | TYR A 61LEU A 133PRO A 84LEU A 92 | None | 1.03A | 5eshA-4qlbA:undetectable | 5eshA-4qlbA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r1z | CYP17A1 PROTEIN (Danio rerio) |
PF00067(p450) | 4 | TYR A 328LEU A 495PRO A 497LEU A 372 | None | 1.25A | 5eshA-4r1zA:33.1 | 5eshA-4r1zA:25.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hs1 | LANOSTEROL 14-ALPHADEMETHYLASE (Saccharomycescerevisiae) |
PF00067(p450) | 4 | TYR A 72LEU A 129PRO A 238LEU A 383 | NoneNoneNoneHEM A 601 (-4.0A) | 0.88A | 5eshA-5hs1A:63.7 | 5eshA-5hs1A:99.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzg | F-BOX/LRR-REPEATMAX2 HOMOLOGSTRIGOLACTONEESTERASE D14 (Arabidopsisthaliana;Oryza sativa) |
PF12697(Abhydrolase_6)no annotation | 4 | TRP A 155LEU A 162PRO A 161LEU B 615 | None | 1.31A | 5eshA-5hzgA:undetectable | 5eshA-5hzgA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l44 | K-26 DIPEPTIDYLCARBOXYPEPTIDASE (Astrosporangiumhypotensionis) |
PF01432(Peptidase_M3) | 4 | TYR A 590LEU A 572PRO A 583LEU A 565 | None | 1.41A | 5eshA-5l44A:undetectable | 5eshA-5l44A:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sv9 | BOR1P BORONTRANSPORTER (Saccharomycesmikatae) |
PF00955(HCO3_cotransp) | 4 | TYR A 55LEU A 412PRO A 61LEU A 404 | None | 1.08A | 5eshA-5sv9A:undetectable | 5eshA-5sv9A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5thw | DEACYLASE (Burkholderiamultivorans) |
PF01546(Peptidase_M20) | 4 | TYR A 360TRP A 405LEU A 202LEU A 414 | None | 1.43A | 5eshA-5thwA:undetectable | 5eshA-5thwA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubk | ACYL-HOMOSERINELACTONE ACYLASE PVDQ (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 4 | TYR A 79LEU A 287PRO A 207LEU A 213 | None | 1.24A | 5eshA-5ubkA:undetectable | 5eshA-5ubkA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v57 | SMOOTHENEDHOMOLOG,FLAVODOXIN,SMOOTHENED HOMOLOG (Desulfovibriovulgaris;Homo sapiens) |
PF00258(Flavodoxin_1)PF01392(Fz)PF01534(Frizzled) | 4 | TYR A 394LEU A 515PRO A 513LEU A 522 | 836 A1201 (-4.6A)None836 A1201 (-4.1A)836 A1201 (-4.6A) | 1.47A | 5eshA-5v57A:1.0 | 5eshA-5v57A:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yhj | CYTOCHROME P450 (Exiguobacteriumsp. AT1b) |
no annotation | 4 | TYR A 382LEU A 389PRO A 385LEU A 249 | None | 1.35A | 5eshA-5yhjA:27.3 | 5eshA-5yhjA:9.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6etz | BETA-GALACTOSIDASE (Arthrobactersp. 32cB) |
no annotation | 4 | TRP A 696LEU A 291PRO A 289LEU A 376 | None | 1.19A | 5eshA-6etzA:undetectable | 5eshA-6etzA:9.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g8r | NUCLEAR BODY PROTEINSP140SHORT-CHAIN VARIABLEFRAGMENT (Homo sapiens) |
no annotation | 4 | TYR B 786LEU A 114PRO A 41LEU A 86 | None | 1.44A | 5eshA-6g8rB:undetectable | 5eshA-6g8rB:11.86 |