SIMILAR PATTERNS OF AMINO ACIDS FOR 5ESG_A_1YNA701_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		4 LEU A 428
TYR A 445
PRO A 379
ILE A 393
 None
 1.34A 5esgA-1f0iA:
0.0		 5esgA-1f0iA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5p NUCLEAR AUTOANTIGEN
SP100-B

(Homo sapiens) 		PF01342
(SAND) 		4 LEU A 666
TYR A 617
PRO A 606
ILE A 598
 None
 1.41A 5esgA-1h5pA:
undetectable		 5esgA-1h5pA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 LEU A 201
TYR A 253
PRO A 234
ILE A 235
 A  D 914 ( 3.8A)
None
None
None
 1.41A 5esgA-1j2bA:
undetectable		 5esgA-1j2bA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsd HAEMAGGLUTININ (HA1
CHAIN)

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 167
TYR A 138
PRO A 244
ILE A 116
 None
 1.32A 5esgA-1jsdA:
0.0		 5esgA-1jsdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks9 2-DEHYDROPANTOATE
2-REDUCTASE

(Escherichia
coli) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A  95
TYR A 151
PRO A 141
ILE A 169
 None
 1.26A 5esgA-1ks9A:
1.3		 5esgA-1ks9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		4 LEU A 484
TYR A 497
PRO A 477
ILE A 478
 None
 1.21A 5esgA-1morA:
0.5		 5esgA-1morA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 LEU A 180
TYR A 215
PRO A 260
ILE A 262
 None
 1.10A 5esgA-1pyfA:
0.0		 5esgA-1pyfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		4 LEU A 329
TYR A 277
PRO A 324
ILE A 322
 None
 1.42A 5esgA-1qfxA:
0.0		 5esgA-1qfxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgl TRICHOMAGLIN

(Trichosanthes
lepiniana) 		PF00445
(Ribonuclease_T2) 		4 LEU A 126
TYR A 102
PRO A  47
ILE A   9
 None
None
None
SO4  A 253 ( 4.8A)
 1.03A 5esgA-1sglA:
undetectable		 5esgA-1sglA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6h DIVALENT CATION
TOLERANCE PROTEIN
CUTA1

(Thermus
thermophilus) 		PF03091
(CutA1) 		4 LEU A  55
TYR A  41
PRO A  80
ILE A  82
 None
 1.13A 5esgA-1v6hA:
undetectable		 5esgA-1v6hA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1b CRTF-RELATED PROTEIN

(Chlorobaculum
tepidum) 		PF00891
(Methyltransf_2) 		4 LEU A 199
TYR A 135
PRO A 202
ILE A 205
 None
 1.34A 5esgA-1x1bA:
undetectable		 5esgA-1x1bA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbt PEPTIDE CHAIN
RELEASE FACTOR 1

(Streptococcus
mutans) 		PF00472
(RF-1)
PF03462
(PCRF) 		4 LEU A 206
TYR A 216
PRO A 209
ILE A 113
 None
 1.22A 5esgA-1zbtA:
undetectable		 5esgA-1zbtA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		4 LEU A  46
TYR A 104
PRO A 151
ILE A  35
 None
 1.13A 5esgA-1zy9A:
undetectable		 5esgA-1zy9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 290
TYR A 240
PRO A 232
ILE A 342
 None
None
None
SO4  A 503 (-3.7A)
 1.36A 5esgA-2b1pA:
undetectable		 5esgA-2b1pA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 LEU A 185
TYR A 501
PRO A 171
ILE A 169
 None
 1.15A 5esgA-2b3xA:
undetectable		 5esgA-2b3xA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		4 LEU A 278
TYR A 229
PRO A 271
ILE A  36
 None
B12  A   0 ( 3.4A)
None
None
 1.17A 5esgA-2bb6A:
undetectable		 5esgA-2bb6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bqx INORGANIC
PYROPHOSPHATASE

(Helicobacter
pylori) 		PF00719
(Pyrophosphatase) 		4 LEU A  88
TYR A 118
PRO A 108
ILE A 109
 None
 1.15A 5esgA-2bqxA:
undetectable		 5esgA-2bqxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 LEU A  57
TYR A 115
PRO A  24
ILE A  62
 None
 1.31A 5esgA-2dpgA:
undetectable		 5esgA-2dpgA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4m HA-17

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17) 		4 LEU C 129
TYR C  77
PRO C 125
ILE C 114
 None
 1.31A 5esgA-2e4mC:
undetectable		 5esgA-2e4mC:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		4 LEU A 198
TYR A 174
PRO A 293
ILE A 292
 None
 1.41A 5esgA-2e5fA:
undetectable		 5esgA-2e5fA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 119
TYR A 349
PRO A 122
ILE A 336
 None
 1.41A 5esgA-2ep5A:
undetectable		 5esgA-2ep5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 LEU A 502
TYR A 687
PRO A 594
ILE A 518
 None
 1.40A 5esgA-2g28A:
undetectable		 5esgA-2g28A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdw TYROCIDINE
SYNTHETASE III

(Brevibacillus
parabrevis) 		PF00550
(PP-binding) 		4 LEU A  65
TYR A  80
PRO A  72
ILE A  41
 None
 1.07A 5esgA-2gdwA:
undetectable		 5esgA-2gdwA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A 234
TYR A 319
PRO A  95
ILE A  94
 PC0  A 999 (-4.2A)
None
PC0  A 999 ( 4.9A)
None
 1.42A 5esgA-2hnzA:
undetectable		 5esgA-2hnzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 LEU A1105
TYR A1155
PRO A1110
ILE A1161
 None
 1.35A 5esgA-2nz9A:
0.4		 5esgA-2nz9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 456
TYR A 545
PRO A 465
ILE A 464
 None
 1.36A 5esgA-2panA:
undetectable		 5esgA-2panA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		4 LEU A 208
TYR A 193
PRO A 299
ILE A 302
 None
 1.36A 5esgA-2q2rA:
undetectable		 5esgA-2q2rA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjz PILO PROTEIN

(Pseudomonas
aeruginosa) 		PF04350
(PilO) 		4 LEU A 173
TYR A 141
PRO A 145
ILE A 146
 None
 1.25A 5esgA-2rjzA:
undetectable		 5esgA-2rjzA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 LEU A  83
TYR A 183
PRO A 126
ILE A 125
 None
 1.39A 5esgA-2vsqA:
undetectable		 5esgA-2vsqA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		4 LEU A 422
TYR A 439
PRO A 374
ILE A 388
 None
 1.26A 5esgA-2ze4A:
undetectable		 5esgA-2ze4A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zym SOLUTE-BINDING
PROTEIN

(Thermoactinomyces
vulgaris) 		PF13416
(SBP_bac_8) 		4 LEU A  85
TYR A 289
PRO A  96
ILE A  97
 None
 1.20A 5esgA-2zymA:
undetectable		 5esgA-2zymA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 LEU A 235
TYR A 243
PRO A 228
ILE A 229
 None
 1.29A 5esgA-3anvA:
0.7		 5esgA-3anvA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cez METHIONINE-R-SULFOXI
DE REDUCTASE

(Burkholderia
pseudomallei) 		PF01641
(SelR) 		4 LEU A 111
TYR A  69
PRO A  81
ILE A  82
 None
 1.19A 5esgA-3cezA:
undetectable		 5esgA-3cezA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 LEU A  76
TYR A 112
PRO A 179
ILE A 180
 None
 1.40A 5esgA-3ciaA:
undetectable		 5esgA-3ciaA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		4 LEU A 310
TYR A  28
PRO A  24
ILE A  57
 None
None
FMN  A 341 (-4.3A)
None
 1.40A 5esgA-3gr8A:
undetectable		 5esgA-3gr8A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcg PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB

(Neisseria
meningitidis) 		PF01641
(SelR) 		4 LEU A 478
TYR A 436
PRO A 448
ILE A 449
 None
 1.41A 5esgA-3hcgA:
undetectable		 5esgA-3hcgA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcg PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB

(Neisseria
meningitidis) 		PF01641
(SelR) 		4 LEU A 501
TYR A 378
PRO A 428
ILE A 449
 None
 1.42A 5esgA-3hcgA:
undetectable		 5esgA-3hcgA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcg PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB

(Neisseria
meningitidis) 		PF01641
(SelR) 		4 LEU A 501
TYR A 436
PRO A 448
ILE A 449
 None
 1.14A 5esgA-3hcgA:
undetectable		 5esgA-3hcgA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxj PYRROLO-QUINOLINE
QUINONE

(Methanococcus
maripaludis) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13570
(PQQ_3) 		4 LEU A 159
TYR A 139
PRO A 142
ILE A 143
 None
 1.20A 5esgA-3hxjA:
undetectable		 5esgA-3hxjA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyn PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

([Eubacterium]
rectale) 		no annotation 4 LEU A 168
TYR A 184
PRO A 110
ILE A  82
 None
MRD  A 189 (-3.6A)
None
None
 1.25A 5esgA-3hynA:
undetectable		 5esgA-3hynA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		4 LEU A  66
TYR A 111
PRO A 104
ILE A 105
 None
EDO  A 908 (-3.9A)
None
None
 1.18A 5esgA-3k8kA:
undetectable		 5esgA-3k8kA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 LEU A 272
TYR A 224
PRO A 265
ILE A  57
 None
B12  A2007 (-3.5A)
None
None
 1.28A 5esgA-3kq4A:
undetectable		 5esgA-3kq4A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 LEU A 303
TYR A 366
PRO A 250
ILE A 251
 None
 1.15A 5esgA-3lq1A:
undetectable		 5esgA-3lq1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE

(Saccharomyces
cerevisiae) 		PF13472
(Lipase_GDSL_2) 		4 LEU A  67
TYR A 214
PRO A 116
ILE A  78
 None
 1.09A 5esgA-3milA:
undetectable		 5esgA-3milA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opx PROTEIN SSM1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		4 LEU A 159
TYR A  42
PRO A 116
ILE A 118
 None
 1.20A 5esgA-3opxA:
1.8		 5esgA-3opxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 LEU A 172
TYR A 157
PRO A 150
ILE A 149
 None
 1.18A 5esgA-3pdiA:
undetectable		 5esgA-3pdiA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhq SAG0897 FAMILY
CRISPR-ASSOCIATED
PROTEIN

(Streptococcus
agalactiae) 		PF09711
(Cas_Csn2) 		4 LEU A 194
TYR A 202
PRO A 198
ILE A  23
 None
 1.12A 5esgA-3qhqA:
undetectable		 5esgA-3qhqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ros NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00171
(Aldedh) 		4 LEU A 283
TYR A 257
PRO A 364
ILE A 365
 None
 1.37A 5esgA-3rosA:
undetectable		 5esgA-3rosA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		4 LEU A  55
TYR A 137
PRO A  45
ILE A  64
 None
 1.34A 5esgA-3si9A:
undetectable		 5esgA-3si9A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyw HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 180
TYR A 151
PRO A 257
ILE A 122
 None
 1.32A 5esgA-3uywA:
undetectable		 5esgA-3uywA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 LEU A  57
TYR A  48
PRO A 281
ILE A 284
 None
 1.35A 5esgA-3wibA:
undetectable		 5esgA-3wibA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddd IMMUNOGENIC PROTEIN

(Ehrlichia
chaffeensis) 		PF16868
(NMT1_3) 		4 LEU A 163
TYR A 125
PRO A 221
ILE A 220
 None
EDO  A 403 ( 4.3A)
None
None
 1.25A 5esgA-4dddA:
undetectable		 5esgA-4dddA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		4 LEU A 380
TYR A  21
PRO A  24
ILE A  25
 None
 1.40A 5esgA-4dzhA:
undetectable		 5esgA-4dzhA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjf GGDEF FAMILY PROTEIN

(Caulobacter
vibrioides) 		PF00563
(EAL) 		4 LEU A 379
TYR A 307
PRO A 310
ILE A 311
 None
 1.40A 5esgA-4hjfA:
undetectable		 5esgA-4hjfA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkx HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU E 177
TYR E 148
PRO E 254
ILE E 120
 None
 1.33A 5esgA-4hkxE:
undetectable		 5esgA-4hkxE:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 LEU A 167
TYR A 251
PRO A 189
ILE A 187
 None
NA  A 306 (-4.0A)
None
None
 1.27A 5esgA-4j2hA:
undetectable		 5esgA-4j2hA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jtv HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 180
TYR A 151
PRO A 257
ILE A 122
 None
 1.32A 5esgA-4jtvA:
undetectable		 5esgA-4jtvA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jug HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 177
TYR A 148
PRO A 254
ILE A 120
 None
 1.31A 5esgA-4jugA:
undetectable		 5esgA-4jugA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3x HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 177
TYR A 148
PRO A 254
ILE A 123
 None
 1.34A 5esgA-4k3xA:
undetectable		 5esgA-4k3xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 469
TYR A 486
PRO A 481
ILE A 480
 None
 1.38A 5esgA-4m7eA:
undetectable		 5esgA-4m7eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc5 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 175
TYR A 148
PRO A 252
ILE A 120
 None
 1.31A 5esgA-4mc5A:
undetectable		 5esgA-4mc5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhr LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Escherichia
coli) 		PF04390
(LptE) 		4 LEU A  55
TYR A 116
PRO A  73
ILE A  37
 None
 1.25A 5esgA-4nhrA:
undetectable		 5esgA-4nhrA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		4 LEU A 319
TYR A 288
PRO A 281
ILE A 312
 None
 0.98A 5esgA-4ofwA:
undetectable		 5esgA-4ofwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN

(Vibrio cholerae) 		PF00501
(AMP-binding) 		4 LEU A  83
TYR A  91
PRO A 106
ILE A 105
 None
 1.14A 5esgA-4oxiA:
undetectable		 5esgA-4oxiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdd TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 LEU A 235
TYR A 240
PRO A 219
ILE A 221
 None
 1.20A 5esgA-4pddA:
undetectable		 5esgA-4pddA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rca SLIT AND NTRK-LIKE
PROTEIN 1

(Homo sapiens) 		PF13855
(LRR_8) 		4 LEU B 198
TYR B 176
PRO B 202
ILE B 204
 None
 1.37A 5esgA-4rcaB:
undetectable		 5esgA-4rcaB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		4 LEU A  65
TYR A 141
PRO A  40
ILE A  71
 None
 1.13A 5esgA-4rotA:
undetectable		 5esgA-4rotA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4h TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		4 LEU A 126
TYR A 168
PRO A 165
ILE A 154
 None
 1.35A 5esgA-4u4hA:
undetectable		 5esgA-4u4hA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		4 LEU A  47
TYR A  38
PRO A 307
ILE A 310
 None
 1.28A 5esgA-4y9sA:
undetectable		 5esgA-4y9sA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk7 DIVALENT-CATION
TOLERANCE PROTEIN
CUTA

(Thermus
thermophilus) 		PF03091
(CutA1) 		4 LEU M  55
TYR M  41
PRO M  80
ILE M  82
 None
 0.99A 5esgA-4zk7M:
undetectable		 5esgA-4zk7M:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 LEU A 139
TYR A 130
PRO A 426
ILE A 447
 None
 1.32A 5esgA-5ah5A:
undetectable		 5esgA-5ah5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 LEU K 667
TYR K1090
PRO K 616
ILE K 617
 None
 1.27A 5esgA-5anbK:
undetectable		 5esgA-5anbK:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 LEU A 250
TYR A 200
PRO A 192
ILE A 303
 None
 1.30A 5esgA-5awmA:
undetectable		 5esgA-5awmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz1 INTEGRASE

(Mouse mammary
tumor virus) 		PF00665
(rve) 		4 LEU A 213
TYR A  85
PRO A  58
ILE A 115
 None
 1.15A 5esgA-5cz1A:
1.6		 5esgA-5cz1A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6h CSUC

(Acinetobacter
baumannii) 		PF00345
(PapD_N) 		4 LEU A 131
TYR A  88
PRO A 119
ILE A   8
 None
 1.39A 5esgA-5d6hA:
undetectable		 5esgA-5d6hA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9q NIH45-46 SINGLE
CHAIN FV

(Homo sapiens) 		PF07686
(V-set) 		4 LEU D  30
TYR D  97
PRO D  33
ILE D  34
 None
 1.26A 5esgA-5d9qD:
undetectable		 5esgA-5d9qD:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 LEU B 970
TYR B1008
PRO B 964
ILE B 962
 None
 1.28A 5esgA-5dlqB:
undetectable		 5esgA-5dlqB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eid ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 2

(Arabidopsis
thaliana) 		PF13637
(Ank_4) 		4 LEU A 335
TYR A 294
PRO A 320
ILE A 321
 None
 1.41A 5esgA-5eidA:
undetectable		 5esgA-5eidA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 LEU A 179
TYR A 229
PRO A 232
ILE A 236
 None
 1.09A 5esgA-5es1A:
undetectable		 5esgA-5es1A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1u 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00701
(DHDPS) 		4 LEU A  54
TYR A 137
PRO A  44
ILE A  63
 None
 1.39A 5esgA-5f1uA:
undetectable		 5esgA-5f1uA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgw EXTRACELLULAR
STREPTODORNASE D

(Streptococcus
pyogenes) 		PF01223
(Endonuclease_NS) 		4 LEU A  99
TYR A 109
PRO A 246
ILE A 204
 None
 1.33A 5esgA-5fgwA:
undetectable		 5esgA-5fgwA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 LEU A  88
TYR A 118
PRO A 230
ILE A 231
 None
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.2A)
None
 0.35A 5esgA-5fsaA:
57.3		 5esgA-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		4 LEU A 423
TYR A 347
PRO A 367
ILE A 366
 None
 1.09A 5esgA-5gooA:
undetectable		 5esgA-5gooA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE

([Eubacterium]
rectale) 		PF00078
(RVT_1) 		4 LEU A  80
TYR A 174
PRO A 200
ILE A 181
 None
 1.04A 5esgA-5hhlA:
undetectable		 5esgA-5hhlA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 LEU A  96
TYR A 126
PRO A 238
ILE A 239
 None
VOR  A 602 ( 3.8A)
None
None
 0.36A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		4 LEU A 312
TYR A 569
PRO A 519
ILE A 501
 None
 1.32A 5esgA-5iheA:
undetectable		 5esgA-5iheA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 960
TYR A 801
PRO A 912
ILE A 915
 None
 1.04A 5esgA-5iudA:
undetectable		 5esgA-5iudA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 LEU A  97
TYR A 127
PRO A 239
ILE A 240
 None
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.8A)
None
 0.65A 5esgA-5jlcA:
59.1		 5esgA-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9o HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU F 177
TYR F 148
PRO F 254
ILE F 120
 None
 1.32A 5esgA-5k9oF:
undetectable		 5esgA-5k9oF:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 308
TYR A 199
PRO A 174
ILE A 175
 None
 1.26A 5esgA-5kiaA:
undetectable		 5esgA-5kiaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 LEU A1586
TYR A1235
PRO A1160
ILE A1111
 None
 1.15A 5esgA-5lkiA:
undetectable		 5esgA-5lkiA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 4 LEU A 297
TYR A 303
PRO A 225
ILE A 224
 None
 1.24A 5esgA-5ngjA:
undetectable		 5esgA-5ngjA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvr PILO PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 173
TYR A 141
PRO A 145
ILE A 146
 None
None
MLY  A 196 ( 4.4A)
None
 1.17A 5esgA-5uvrA:
undetectable		 5esgA-5uvrA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 4 LEU A 178
TYR A 138
PRO A 149
ILE A 148
 None
 1.26A 5esgA-5vehA:
undetectable		 5esgA-5vehA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6t HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 177
TYR A 148
PRO A 254
ILE A 123
 None
 1.31A 5esgA-5w6tA:
undetectable		 5esgA-5w6tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 LEU A 274
TYR A 619
PRO A 570
ILE A 571
 None
 1.17A 5esgA-5x3jA:
undetectable		 5esgA-5x3jA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 4 LEU A 432
TYR A 345
PRO A 377
ILE A 378
 None
 1.38A 5esgA-5xnrA:
undetectable		 5esgA-5xnrA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z73 ALR0819 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 4 LEU A 424
TYR A 348
PRO A 368
ILE A 367
 None
 1.25A 5esgA-5z73A:
undetectable		 5esgA-5z73A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d8w HEMAGGLUTININ

(Influenza A
virus) 		no annotation 4 LEU A 176
TYR A 147
PRO A 253
ILE A 118
 None
 1.32A 5esgA-6d8wA:
undetectable		 5esgA-6d8wA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dzs HOMOSERINE
DEHYDROGENASE

(Mycolicibacterium
hassiacum) 		no annotation 4 LEU A 144
TYR A 129
PRO A 139
ILE A 138
 None
 1.27A 5esgA-6dzsA:
undetectable		 5esgA-6dzsA:
undetectable