SIMILAR PATTERNS OF AMINO ACIDS FOR 5ESG_A_1YNA701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 ILE A 105
VAL A 180
THR A  78
LEU A 195
HIS A 196
 None
None
None
None
ZN  A 400 (-3.2A)
 1.27A 5esgA-1ayeA:
0.0		 5esgA-1ayeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd CARBOXYPEPTIDASE A2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 ILE A 460
VAL A 536
THR A 433
LEU A 551
HIS A 552
 None
None
None
None
ZN  A 301 ( 3.3A)
 1.23A 5esgA-1dtdA:
0.0		 5esgA-1dtdA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 TYR A 213
ILE A 135
PHE A 151
VAL A 448
LEU A 360
 None
 1.38A 5esgA-1ff9A:
undetectable		 5esgA-1ff9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLU A 202
TYR A 319
PHE A 282
GLY A 259
THR A 254
 None
SO4  A 600 (-4.8A)
None
None
None
 1.33A 5esgA-1fnoA:
undetectable		 5esgA-1fnoA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 TYR A 366
PHE A 509
ILE A 468
GLY A 430
HIS A 413
 None
 1.12A 5esgA-1fprA:
0.0		 5esgA-1fprA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1goj KINESIN HEAVY CHAIN

(Neurospora
crassa) 		PF00225
(Kinesin) 		5 ILE A 330
PHE A 323
VAL A  54
GLY A 266
LEU A 236
 None
 1.40A 5esgA-1gojA:
undetectable		 5esgA-1gojA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03372
(Exo_endo_phos) 		5 PHE A 686
ILE A 660
TYR A 688
PHE A 695
HIS A 827
 None
 1.21A 5esgA-1i9zA:
undetectable		 5esgA-1i9zA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 GLU A 677
ILE A 629
GLY A 463
THR A 438
LEU A 644
 CA  A 779 (-3.4A)
None
None
None
None
 1.37A 5esgA-1j0nA:
undetectable		 5esgA-1j0nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLU A 494
ILE A 501
GLY A 315
THR A 397
LEU A 514
 None
 1.25A 5esgA-1jmyA:
0.0		 5esgA-1jmyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jra ERV2 PROTEIN,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF04777
(Evr1_Alr) 		5 GLU A  66
ILE A 103
PHE A  22
LEU A  41
HIS A  42
 None
 1.36A 5esgA-1jraA:
undetectable		 5esgA-1jraA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwq N-ACETYLMURAMOYL-L-A
LANINE AMIDASE CWLV

(Paenibacillus
polymyxa) 		PF01520
(Amidase_3) 		5 PHE A 104
VAL A  65
GLY A 171
THR A 173
LEU A  41
 None
 1.33A 5esgA-1jwqA:
undetectable		 5esgA-1jwqA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Leishmania
mexicana) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 GLU A  50
PHE A  91
ILE A  89
PHE A 101
GLY A 106
 None
None
None
BCP  A 401 ( 4.9A)
None
 1.31A 5esgA-1m66A:
undetectable		 5esgA-1m66A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		5 PHE A 210
ILE A 179
VAL A 164
GLY A 193
THR A 218
 None
 1.33A 5esgA-1nmoA:
undetectable		 5esgA-1nmoA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		5 ILE A 168
TYR A 164
VAL A 137
GLY A 202
THR A  67
 None
 1.28A 5esgA-1ue8A:
26.6		 5esgA-1ue8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		5 ILE A  78
VAL A 185
LEU A 117
HIS A  12
MET A  14
 None
 1.37A 5esgA-1z7cA:
undetectable		 5esgA-1z7cA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 GLU A 421
PHE A 362
PHE A 210
GLY A 305
HIS A 242
 None
None
IND  A 503 ( 4.4A)
None
None
 1.32A 5esgA-2b24A:
undetectable		 5esgA-2b24A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boa CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 ILE A1105
VAL A1180
THR A1078
LEU A1195
HIS A1196
 None
None
None
None
ZN  A1402 (-3.1A)
 1.22A 5esgA-2boaA:
undetectable		 5esgA-2boaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dd7 GREEN FLUORESCENT
PROTEIN

(Chiridius
poppei) 		PF01353
(GFP) 		5 TYR A 101
PHE A  45
ILE A 125
PHE A  19
GLY A 116
 CR2  A  56 ( 4.5A)
None
None
None
None
 1.36A 5esgA-2dd7A:
undetectable		 5esgA-2dd7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l1l EXPORTIN-1

(Homo sapiens) 		no annotation 5 GLU B 613
ILE B 521
GLY B 549
THR B 587
LEU B 569
 None
 1.21A 5esgA-2l1lB:
undetectable		 5esgA-2l1lB:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		5 ILE A 248
GLY A 197
THR A 140
LEU A 165
HIS A 167
 CA  A 302 (-4.5A)
None
None
None
None
 1.35A 5esgA-2p1rA:
undetectable		 5esgA-2p1rA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		5 TYR A 449
VAL A 342
GLY A 209
THR A 211
LEU A 301
 None
 1.40A 5esgA-2p9bA:
undetectable		 5esgA-2p9bA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcu CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 ILE A 105
VAL A 180
THR A  78
LEU A 195
HIS A 196
 None
None
None
None
ZN  A 999 ( 3.1A)
 1.25A 5esgA-2pcuA:
undetectable		 5esgA-2pcuA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 GLU A 112
ILE A 244
GLY A 225
LEU A  77
MET A  81
 None
 1.19A 5esgA-2pi5A:
undetectable		 5esgA-2pi5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy1 PECTATE LYASE II

(Xanthomonas
campestris) 		PF00544
(Pec_lyase_C) 		5 TYR A 329
ILE A 298
PHE A 246
GLY A 253
HIS A 240
 None
 1.32A 5esgA-2qy1A:
undetectable		 5esgA-2qy1A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2

(Homo sapiens) 		PF00709
(Adenylsucc_synt) 		5 PHE A  94
ILE A  95
VAL A 293
GLY A 234
MET A 285
 None
 1.38A 5esgA-2v40A:
undetectable		 5esgA-2v40A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyw HEMOGLOBIN

(Fasciola
hepatica) 		PF00042
(Globin) 		5 GLU A 134
PHE A 109
GLY A  95
LEU A  78
MET A 141
 None
HEM  A 149 (-4.3A)
None
None
HEM  A 149 (-3.9A)
 1.27A 5esgA-2vywA:
undetectable		 5esgA-2vywA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		5 TYR A  54
PHE A 333
GLY A 194
THR A 192
HIS A  26
 None
 1.13A 5esgA-2x4gA:
undetectable		 5esgA-2x4gA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aaf WERNER SYNDROME
ATP-DEPENDENT
HELICASE

(Homo sapiens) 		PF09382
(RQC) 		5 GLU A1030
ILE A1062
PHE A1018
GLY A 960
LEU A 967
 None
 1.32A 5esgA-3aafA:
undetectable		 5esgA-3aafA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Canis lupus) 		PF00344
(SecY) 		5 GLU A 102
ILE A  84
GLY A  90
THR A 337
MET A  96
 None
 1.32A 5esgA-3dknA:
1.3		 5esgA-3dknA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 198
TYR A 207
GLY A 158
THR A 223
HIS A 251
 None
 1.17A 5esgA-3gazA:
undetectable		 5esgA-3gazA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 GLU A 471
PHE A 494
ILE A 484
PHE A 446
GLY A 432
 None
 1.39A 5esgA-3gdeA:
undetectable		 5esgA-3gdeA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 TYR A 117
GLU A 112
VAL A  15
LEU A  61
MET A  63
 None
 1.16A 5esgA-3glqA:
undetectable		 5esgA-3glqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 GLU A 463
GLY A 438
THR A  14
LEU A 281
MET A 456
 None
FAD  A 500 (-3.6A)
FAD  A 500 (-3.5A)
None
None
 1.31A 5esgA-3lovA:
undetectable		 5esgA-3lovA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls2 S-FORMYLGLUTATHIONE
HYDROLASE

(Pseudoalteromonas
haloplanktis) 		PF00756
(Esterase) 		5 TYR A 260
PHE A 104
GLY A 182
HIS A 146
MET A 148
 None
 1.35A 5esgA-3ls2A:
undetectable		 5esgA-3ls2A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		5 GLU A 133
PHE A 144
ILE A 146
GLY A 172
LEU A 128
 None
 1.25A 5esgA-3m3pA:
undetectable		 5esgA-3m3pA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 GLU A 224
PHE A 149
PHE A 204
THR A 134
LEU A 109
 None
 1.24A 5esgA-3mc2A:
undetectable		 5esgA-3mc2A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		5 GLU A 271
VAL A 340
GLY A 155
LEU A  93
HIS A  92
 None
None
None
None
ZN  A   1 ( 3.2A)
 1.23A 5esgA-3mtwA:
undetectable		 5esgA-3mtwA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		5 TYR A 125
PHE A 177
ILE A 187
GLY A 184
LEU A 237
 None
 1.38A 5esgA-3mx3A:
undetectable		 5esgA-3mx3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00287
(Na_K-ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
 None
 1.12A 5esgA-3n23B:
undetectable		 5esgA-3n23B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngm EXTRACELLULAR LIPASE

(Fusarium
graminearum) 		PF01764
(Lipase_3) 		5 GLU A 238
PHE A 261
ILE A  16
TYR A 169
GLY A  10
 None
 1.36A 5esgA-3ngmA:
undetectable		 5esgA-3ngmA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		5 TYR A 853
PHE A 877
ILE A 809
GLY A 846
MET A 866
 None
 1.27A 5esgA-3ob8A:
undetectable		 5esgA-3ob8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 PHE A 108
ILE A 104
PHE A 282
VAL A 291
HIS A 333
 None
None
None
HEA  A   2 (-4.2A)
HEA  A   2 ( 3.3A)
 1.20A 5esgA-3omnA:
1.3		 5esgA-3omnA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 TYR A 943
VAL A 899
GLY A 815
THR A 754
LEU A 880
 None
 1.38A 5esgA-3psfA:
undetectable		 5esgA-3psfA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 TYR A 943
VAL A 899
GLY A 815
THR A 754
LEU A 880
 None
 1.35A 5esgA-3psiA:
undetectable		 5esgA-3psiA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 GLU A 182
PHE A  29
ILE A  24
GLY A 113
THR A  45
 None
 1.16A 5esgA-3q3uA:
undetectable		 5esgA-3q3uA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6h ENOYL-COA HYDRATASE,
ECHA3

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 TYR A 154
ILE A  76
PHE A  62
VAL A 131
GLY A  81
 None
 1.06A 5esgA-3r6hA:
undetectable		 5esgA-3r6hA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Burkholderia
pseudomallei) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		5 ILE A 216
VAL A 273
GLY A 192
THR A 177
LEU A 197
 None
 1.16A 5esgA-3tk8A:
undetectable		 5esgA-3tk8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 PHE A  48
ILE A  47
TYR A 299
GLY A 228
HIS A 158
 None
 1.22A 5esgA-3tqoA:
undetectable		 5esgA-3tqoA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF04166
(PdxA) 		5 PHE A 199
ILE A 161
PHE A 205
LEU A 360
HIS A 361
 None
 1.31A 5esgA-3tsnA:
undetectable		 5esgA-3tsnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE

(Caulobacter
vibrioides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A 200
TYR A 187
GLY A 225
THR A 257
LEU A 233
 None
 1.14A 5esgA-3vcnA:
undetectable		 5esgA-3vcnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtf UDP-GLUCOSE
6-DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A 172
TYR A 189
GLY A 175
LEU A 119
HIS A 118
 None
 1.38A 5esgA-3vtfA:
undetectable		 5esgA-3vtfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wob HYPOTHETICAL PROTEIN

(Sus scrofa) 		PF01419
(Jacalin) 		5 GLU A  36
PHE A  29
ILE A 142
GLY A 146
LEU A 130
 None
 1.38A 5esgA-3wobA:
undetectable		 5esgA-3wobA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		5 PHE A 557
PHE A  63
VAL A 304
THR A  76
LEU A  45
 None
 1.26A 5esgA-3x3yA:
undetectable		 5esgA-3x3yA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4alb PHENOLIC ACID
DECARBOXYLASE PADC

(Bacillus
subtilis) 		PF05870
(PA_decarbox) 		5 GLU A  78
ILE A  29
PHE A   4
GLY A   6
LEU A 133
 None
 1.39A 5esgA-4albA:
undetectable		 5esgA-4albA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		5 TYR A 256
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.34A 5esgA-4b6gA:
undetectable		 5esgA-4b6gA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		5 ILE A 192
VAL A 368
GLY A 172
THR A 235
LEU A 224
 None
 1.38A 5esgA-4bl3A:
undetectable		 5esgA-4bl3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		5 PHE A  70
ILE A 275
PHE A  74
VAL A 112
GLY A 252
 None
 0.98A 5esgA-4e3eA:
undetectable		 5esgA-4e3eA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flm S-FORMYLGLUTATHIONE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF00756
(Esterase) 		5 TYR A 278
PHE A 110
GLY A 198
HIS A 160
MET A 162
 None
None
None
SDP  A 161 ( 3.9A)
None
 1.36A 5esgA-4flmA:
undetectable		 5esgA-4flmA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 TYR A 154
ILE A  76
PHE A  62
VAL A 131
GLY A  81
 None
 0.99A 5esgA-4fn7A:
undetectable		 5esgA-4fn7A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		5 ILE A  83
PHE A   3
GLY A  32
LEU A 160
HIS A 159
 None
None
None
None
CL  A 302 (-4.7A)
 1.26A 5esgA-4h3zA:
undetectable		 5esgA-4h3zA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084

(Cycloclasticus
sp. P1) 		PF12697
(Abhydrolase_6) 		5 PHE A  63
ILE A  60
PHE A 193
GLY A  33
LEU A 140
 None
None
None
CL  A 301 (-4.0A)
None
 1.19A 5esgA-4i3fA:
undetectable		 5esgA-4i3fA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLU A 425
VAL A 418
GLY A 380
THR A 330
LEU A 390
 None
None
RUB  A 501 (-3.3A)
None
None
 1.40A 5esgA-4mkvA:
undetectable		 5esgA-4mkvA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nek ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		5 ILE A 105
VAL A 164
GLY A 138
LEU A 156
MET A 143
 None
 1.35A 5esgA-4nekA:
undetectable		 5esgA-4nekA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		5 GLU A  35
GLY A 140
THR A 263
HIS A  41
MET A  43
 None
 1.26A 5esgA-4pf8A:
undetectable		 5esgA-4pf8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwt PEPTIDOGLYCAN-ASSOCI
ATED LIPOPROTEIN

(Yersinia pestis) 		PF00691
(OmpA) 		5 TYR A 168
PHE A  68
VAL A 141
GLY A  76
HIS A  86
 None
 1.32A 5esgA-4pwtA:
undetectable		 5esgA-4pwtA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 GLU A 175
ILE A 484
TYR A  28
LEU A  36
HIS A 209
 None
 1.01A 5esgA-4qfuA:
undetectable		 5esgA-4qfuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3
NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF03399
(SAC3_GANP) 		5 GLU A 420
ILE B 376
PHE A 425
VAL B 333
LEU B 407
 None
 1.04A 5esgA-4trqA:
undetectable		 5esgA-4trqA:
18.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		5 TYR A  68
PHE A 130
TYR A 136
PHE A 229
HIS A 374
 None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
 0.98A 5esgA-4uymA:
52.5		 5esgA-4uymA:
50.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 PHE A 860
ILE A 863
PHE A 771
VAL A 815
LEU A 781
 None
 1.22A 5esgA-4w8yA:
undetectable		 5esgA-4w8yA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbl PHOTOSESITIZER
MKILLERORANGE

(Hydrozoa) 		PF01353
(GFP) 		5 GLU A  21
PHE A 165
ILE A 142
PHE A  98
MET A 104
 None
 1.32A 5esgA-4zblA:
undetectable		 5esgA-4zblA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT
PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 GLU A 248
ILE C 149
TYR C 146
GLY C 112
THR C  56
 None
 1.33A 5esgA-4zohA:
undetectable		 5esgA-4zohA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 5 ILE B 120
GLY B 136
THR B  21
LEU B   4
HIS B   3
 MTA  B 401 (-3.7A)
None
None
None
None
 1.28A 5esgA-5co4B:
undetectable		 5esgA-5co4B:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 TYR A 160
PHE A  75
GLY A 146
THR A 248
LEU A 244
 None
 1.19A 5esgA-5dfaA:
undetectable		 5esgA-5dfaA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm7 50S RIBOSOMAL
PROTEIN L5

(Deinococcus
radiodurans) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 GLU D  32
PHE D 177
ILE D 117
GLY D 174
LEU D 100
 A  Y  47 ( 4.6A)
None
None
None
None
 1.35A 5esgA-5dm7D:
undetectable		 5esgA-5dm7D:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 312
PHE A 430
VAL A 435
THR A 413
LEU A 410
 None
 1.30A 5esgA-5eb5A:
undetectable		 5esgA-5eb5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 GLU A 659
VAL A 614
GLY A 591
LEU A 561
HIS A 562
 None
 1.21A 5esgA-5ehkA:
undetectable		 5esgA-5ehkA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eog PROTEIN MAB-21-LIKE
1

(Homo sapiens) 		PF03281
(Mab-21) 		5 GLU A  75
PHE A  86
ILE A 117
PHE A 174
VAL A 231
 None
 1.19A 5esgA-5eogA:
undetectable		 5esgA-5eogA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		5 TYR C 797
PHE C 417
ILE C 427
TYR C 457
PHE C 389
 None
 1.31A 5esgA-5exrC:
undetectable		 5esgA-5exrC:
18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 GLY A 308
THR A 311
LEU A 376
HIS A 377
MET A 508
 HEM  A 580 (-3.6A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.10A 5esgA-5fsaA:
57.3		 5esgA-5fsaA:
59.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		11 TYR A  64
PHE A 126
ILE A 131
TYR A 132
PHE A 228
VAL A 234
GLY A 307
THR A 311
LEU A 376
HIS A 377
MET A 508
 None
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
None
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 0.56A 5esgA-5fsaA:
57.3		 5esgA-5fsaA:
59.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 TYR A 176
ILE A  44
VAL A 215
GLY A 126
LEU A 259
 None
 1.32A 5esgA-5hqbA:
undetectable		 5esgA-5hqbA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		6 ILE A 139
TYR A 140
VAL A 242
THR A 318
LEU A 380
MET A 509
 VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
None
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.42A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 TYR A  72
GLY A 315
THR A 318
LEU A 380
HIS A 381
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.91A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		10 TYR A  72
PHE A 134
ILE A 139
TYR A 140
PHE A 236
VAL A 242
GLY A 314
THR A 318
LEU A 380
HIS A 381
 None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
None
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.48A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 TYR A 199
ILE A 351
TYR A 353
GLY A 167
LEU A 131
 None
 1.33A 5esgA-5idnA:
undetectable		 5esgA-5idnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 TYR A 506
ILE A 296
VAL A 430
GLY A 301
LEU A 382
 None
 1.10A 5esgA-5ihrA:
undetectable		 5esgA-5ihrA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		11 TYR A  73
PHE A 135
ILE A 140
TYR A 141
PHE A 237
VAL A 243
GLY A 315
THR A 319
LEU A 381
HIS A 382
MET A 512
 1YN  A 602 (-4.9A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
None
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.5A)
 0.57A 5esgA-5jlcA:
59.1		 5esgA-5jlcA:
83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 5 TYR A 528
GLY A 496
THR A 432
LEU A 335
HIS A 233
 None
 1.30A 5esgA-5mqpA:
undetectable		 5esgA-5mqpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 GLU A2331
PHE A1551
ILE A1557
TYR A1618
GLY A1549
 None
 1.34A 5esgA-5nugA:
undetectable		 5esgA-5nugA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLU A 206
ILE A 115
GLY A 323
LEU A 327
MET A 294
 MG  A1002 ( 3.0A)
None
None
None
None
 1.36A 5esgA-5nv3A:
undetectable		 5esgA-5nv3A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 115
TYR A 275
GLY A 323
LEU A 327
HIS A 328
 None
None
None
None
CAP  A1001 (-4.0A)
 1.39A 5esgA-5nv3A:
undetectable		 5esgA-5nv3A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN

(Cupriavidus
necator) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		5 GLU A 189
ILE A  75
GLY A   9
LEU A  92
HIS A 114
 CA  A 302 ( 3.8A)
NAD  A 301 (-4.2A)
NAD  A 301 (-3.4A)
NAD  A 301 (-4.1A)
ZN  A 303 ( 3.3A)
 1.14A 5esgA-5t57A:
undetectable		 5esgA-5t57A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDD
TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDG

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF12838
(Fer4_7) 		5 GLU B  46
ILE D  11
GLY G  51
THR B  31
HIS B  44
 None
 1.36A 5esgA-5t5iB:
undetectable		 5esgA-5t5iB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vws CYTOCHROME P450

(Thermobispora
bispora) 		PF00067
(p450) 		5 GLU A 268
PHE A 374
ILE A 372
PHE A 380
GLY A  14
 None
 1.21A 5esgA-5vwsA:
29.0		 5esgA-5vwsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 5 TYR A  16
ILE A 382
VAL A  78
GLY A 376
LEU A 361
 None
 1.28A 5esgA-5xb7A:
undetectable		 5esgA-5xb7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Saccharomyces
cerevisiae) 		no annotation 5 GLU D 117
PHE C 144
ILE C 148
LEU D 179
HIS D 178
 None
None
None
None
ZN  D 301 (-3.2A)
 1.23A 5esgA-5xynD:
undetectable		 5esgA-5xynD:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 5 PHE A 114
TYR A 120
PHE A 292
THR A 297
LEU A 358
 TPF  A 506 (-4.4A)
None
TPF  A 506 ( 4.0A)
HEM  A 501 (-3.4A)
TPF  A 506 ( 4.4A)
 1.38A 5esgA-6ay4A:
42.9		 5esgA-6ay4A:
33.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 5 GLU B 178
TYR B 249
PHE B 288
GLY B 277
LEU B 225
 None
 1.31A 5esgA-6c6lB:
undetectable		 5esgA-6c6lB:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 5 PHE A 652
ILE A 711
PHE A 647
VAL A 600
THR A 363
 None
 1.26A 5esgA-6f8zA:
undetectable		 5esgA-6f8zA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 5 GLU A 434
VAL A 452
GLY A 408
THR A 410
LEU A 357
 QPS  A 601 ( 3.7A)
None
None
None
None
 1.10A 5esgA-6gngA:
undetectable		 5esgA-6gngA:
undetectable