SIMILAR PATTERNS OF AMINO ACIDS FOR 5ESF_A_TPFA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		4 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.85A 5esfA-1a2oA:
0.0		 5esfA-1a2oA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.91A 5esfA-1c30A:
0.0		 5esfA-1c30A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7k ZINC ENDOPROTEASE

(Streptomyces
caespitosus) 		PF02031
(Peptidase_M7) 		4 TYR A   6
ILE A  65
TYR A  44
GLY A  86
 None
 0.90A 5esfA-1c7kA:
undetectable		 5esfA-1c7kA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica) 		PF01339
(CheB_methylest) 		4 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.84A 5esfA-1chdA:
0.0		 5esfA-1chdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dfx DESULFOFERRODOXIN

(Desulfovibrio
desulfuricans) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 TYR A   7
ILE A  15
GLY A 119
THR A  41
 None
 0.93A 5esfA-1dfxA:
0.0		 5esfA-1dfxA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 TYR A  44
TYR A  41
GLY A 205
LEU A  82
 None
 0.70A 5esfA-1ee0A:
undetectable		 5esfA-1ee0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A

(Robinia
pseudoacacia) 		PF00139
(Lectin_legB) 		4 TYR A 170
ILE A 168
PHE A  56
LEU A 202
 None
 0.89A 5esfA-1fnzA:
0.0		 5esfA-1fnzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 ILE A  81
TYR A   8
THR A 637
LEU A 663
 None
 0.80A 5esfA-1j1wA:
2.2		 5esfA-1j1wA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 PHE A 192
ILE A 179
PHE A 196
GLY A 231
 None
 0.93A 5esfA-1khoA:
undetectable		 5esfA-1khoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		4 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.90A 5esfA-1l0qA:
undetectable		 5esfA-1l0qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrf REGULATORY PROTEIN
BLAR1

(Bacillus
licheniformis) 		PF00905
(Transpeptidase) 		4 PHE A 567
TYR A 596
PHE A 554
GLY A 538
 None
 0.82A 5esfA-1nrfA:
undetectable		 5esfA-1nrfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 PHE A  61
ILE A  41
GLY A  65
THR A  69
 None
 0.94A 5esfA-1oa1A:
undetectable		 5esfA-1oa1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE

(Mycobacterium
bovis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		4 ILE A 177
GLY A 153
THR A 138
LEU A 158
 None
 0.88A 5esfA-1tdtA:
undetectable		 5esfA-1tdtA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		4 ILE A 210
GLY A 213
THR A 216
LEU A 184
 None
 0.82A 5esfA-1tisA:
1.1		 5esfA-1tisA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 4 TYR A 171
ILE A 143
GLY A 139
LEU A 292
 None
 0.93A 5esfA-1u5uA:
undetectable		 5esfA-1u5uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		4 TYR A 271
ILE A 268
GLY A 278
LEU A 243
 None
None
None
CL  A 501 (-4.3A)
 0.91A 5esfA-1wkyA:
undetectable		 5esfA-1wkyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 PHE A  41
ILE A  21
GLY A 262
LEU A 214
 None
 0.85A 5esfA-1womA:
undetectable		 5esfA-1womA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 TYR A  76
PHE A  83
THR A 260
LEU A 321
 ESL  A 471 ( 3.8A)
None
HEM  A 470 (-3.6A)
HEM  A 470 (-4.1A)
 0.90A 5esfA-1x8vA:
35.3		 5esfA-1x8vA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 TYR A 196
ILE A 194
GLY A 189
THR A 169
LEU A  48
 None
 1.48A 5esfA-2azkA:
undetectable		 5esfA-2azkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 PHE A 221
ILE A 205
TYR A 146
THR A1053
 None
 0.89A 5esfA-2b39A:
undetectable		 5esfA-2b39A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b71 CYCLOPHILIN-LIKE
PROTEIN

(Plasmodium
yoelii) 		PF00160
(Pro_isomerase) 		4 PHE A  66
ILE A  41
PHE A 139
THR A  78
 None
 0.93A 5esfA-2b71A:
undetectable		 5esfA-2b71A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 TYR A 660
ILE A 662
GLY A 670
LEU A 293
 None
 0.88A 5esfA-2d3tA:
undetectable		 5esfA-2d3tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 TYR A 380
PHE A 769
TYR A 377
GLY A 398
 None
 0.77A 5esfA-2eaeA:
undetectable		 5esfA-2eaeA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 ILE X 618
GLY X 342
THR X 344
LEU X 495
 None
 0.88A 5esfA-2epkX:
1.0		 5esfA-2epkX:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtp REGULATOR OF
G-PROTEIN SIGNALING
1

(Homo sapiens) 		PF00615
(RGS) 		4 PHE C 177
ILE C 182
GLY C  82
LEU C  61
 None
 0.82A 5esfA-2gtpC:
undetectable		 5esfA-2gtpC:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2r KV
CHANNEL-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE E  74
ILE E  77
TYR E  78
PHE E  98
LEU E 115
 None
 1.43A 5esfA-2i2rE:
undetectable		 5esfA-2i2rE:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		4 TYR A 150
PHE A 143
ILE A 146
PHE A 120
 None
 0.88A 5esfA-2ip1A:
undetectable		 5esfA-2ip1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		4 PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.90A 5esfA-2jfwA:
undetectable		 5esfA-2jfwA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m83 PROTEIN PHOSPHATASE
1 REGULATORY SUBUNIT
3A

(Oryctolagus
cuniculus) 		PF03370
(CBM_21) 		5 ILE A 174
TYR A 172
GLY A 146
THR A 135
LEU A 231
 None
 1.23A 5esfA-2m83A:
undetectable		 5esfA-2m83A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.73A 5esfA-2o7rA:
undetectable		 5esfA-2o7rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 TYR A 338
PHE A 684
TYR A 335
GLY A 355
 None
 0.76A 5esfA-2rdyA:
undetectable		 5esfA-2rdyA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli) 		PF00154
(RecA) 		4 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
 0.81A 5esfA-2rebA:
undetectable		 5esfA-2rebA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		4 TYR A 556
PHE A 534
ILE A 537
GLY A 509
 None
 0.75A 5esfA-2rfoA:
undetectable		 5esfA-2rfoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 TYR A 143
PHE A 136
TYR A 139
GLY A 181
 None
 0.85A 5esfA-2v28A:
undetectable		 5esfA-2v28A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq5 S-NORCOCLAURINE
SYNTHASE

(Thalictrum
flavum) 		PF00407
(Bet_v_1) 		4 ILE A 143
TYR A  63
PHE A 112
LEU A  72
 None
HBA  A1203 (-4.7A)
HBA  A1203 (-4.6A)
None
 0.89A 5esfA-2vq5A:
undetectable		 5esfA-2vq5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 ILE A 260
PHE A 208
GLY A 210
LEU A 219
 None
 0.90A 5esfA-2wedA:
undetectable		 5esfA-2wedA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Neisseria
meningitidis) 		PF00132
(Hexapep) 		4 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.77A 5esfA-2wlcA:
undetectable		 5esfA-2wlcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		4 ILE A 326
TYR A 327
PHE A 319
LEU A 210
 None
NM2  A1504 (-4.4A)
None
None
 0.88A 5esfA-2wsxA:
undetectable		 5esfA-2wsxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		5 PHE A   6
ILE A 298
TYR A   9
GLY A 282
LEU A 255
 None
 1.49A 5esfA-2y35A:
undetectable		 5esfA-2y35A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 PHE A 307
PHE A  27
GLY A 170
LEU A 145
 None
HEM  A 354 (-4.4A)
HEM  A 354 (-3.5A)
BXO  A 355 ( 4.7A)
 0.94A 5esfA-3a18A:
undetectable		 5esfA-3a18A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 TYR A 357
ILE A 381
GLY A 421
LEU A 261
 None
GOL  A 915 (-4.7A)
None
None
 0.86A 5esfA-3a21A:
undetectable		 5esfA-3a21A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.89A 5esfA-3c8eA:
undetectable		 5esfA-3c8eA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
None
ADP  A 502 (-3.3A)
None
 0.92A 5esfA-3cmtA:
undetectable		 5esfA-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 TYR A1065
ILE A1192
GLY A1071
THR A1242
 None
None
ADP  A1502 (-3.4A)
None
 0.92A 5esfA-3cmtA:
undetectable		 5esfA-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 TYR A2065
ILE A2192
GLY A2071
THR A2242
 None
None
ADP  A2502 (-3.4A)
None
 0.92A 5esfA-3cmtA:
undetectable		 5esfA-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 TYR A3065
ILE A3192
GLY A3071
THR A3242
 None
None
ADP  A3502 (-3.4A)
None
 0.92A 5esfA-3cmtA:
undetectable		 5esfA-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 TYR A4065
ILE A4192
GLY A4071
THR A4242
 None
None
ADP  A4502 (-3.2A)
None
 0.92A 5esfA-3cmtA:
undetectable		 5esfA-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
None
ANP  A 400 (-3.4A)
None
 0.93A 5esfA-3cmvA:
undetectable		 5esfA-3cmvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 TYR A1065
ILE A1192
GLY A1071
THR A1242
 None
None
ANP  A1400 (-3.1A)
None
 0.85A 5esfA-3cmvA:
undetectable		 5esfA-3cmvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 TYR A2065
ILE A2192
GLY A2071
THR A2242
 None
None
ANP  A2400 (-3.7A)
None
 0.87A 5esfA-3cmvA:
undetectable		 5esfA-3cmvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 ILE A 124
TYR A 128
GLY A 118
LEU A 107
 None
 0.71A 5esfA-3ctzA:
undetectable		 5esfA-3ctzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		4 ILE A 281
TYR A 282
GLY A 152
LEU A 203
 DMS  A1407 (-4.9A)
DMS  A1407 ( 4.2A)
None
None
 0.92A 5esfA-3d7rA:
undetectable		 5esfA-3d7rA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8b FIDGETIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 PHE A 486
ILE A 539
PHE A 524
LEU A 559
 None
 0.87A 5esfA-3d8bA:
undetectable		 5esfA-3d8bA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc6 SUPEROXIDE DISMUTASE
[MN] 1

(Caenorhabditis
elegans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 TYR A 164
ILE A 179
TYR A 175
GLY A 123
THR A 138
 None
 1.46A 5esfA-3dc6A:
0.2		 5esfA-3dc6A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		4 ILE A 159
TYR A 160
PHE A 137
THR A 107
 None
 0.92A 5esfA-3dwcA:
undetectable		 5esfA-3dwcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 TYR A 171
ILE A 143
GLY A 139
LEU A 292
 None
 0.78A 5esfA-3dy5A:
undetectable		 5esfA-3dy5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		4 PHE A 126
GLY A  86
THR A  59
LEU A 259
 None
SAH  A 901 (-3.1A)
None
None
 0.93A 5esfA-3evcA:
undetectable		 5esfA-3evcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD

(Bacteroides
fragilis) 		PF07876
(Dabb) 		4 PHE A   8
ILE A  57
GLY A  82
LEU A  33
 None
 0.66A 5esfA-3fmbA:
undetectable		 5esfA-3fmbA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		5 TYR A 240
ILE A 135
PHE A  95
GLY A 167
LEU A 197
 None
None
None
SEP  A 165 ( 4.0A)
None
 1.48A 5esfA-3ga7A:
undetectable		 5esfA-3ga7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbd CLASS IV CHITINASE
CHIA4-PA2

(Picea abies) 		PF00182
(Glyco_hydro_19) 		5 PHE A  80
ILE A  81
TYR A  77
PHE A 107
LEU A 241
 None
 1.40A 5esfA-3hbdA:
undetectable		 5esfA-3hbdA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT

(Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 PHE C  77
ILE C  80
GLY C 112
LEU C 148
 FAD  C 900 (-4.2A)
None
FAD  C 900 ( 4.3A)
None
 0.91A 5esfA-3hrdC:
1.6		 5esfA-3hrdC:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		4 PHE A 154
ILE A 320
PHE A 351
GLY A  54
 None
 0.73A 5esfA-3i3vA:
undetectable		 5esfA-3i3vA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		4 ILE A 155
TYR A 154
PHE A 366
GLY A  38
 None
PLP  A 500 (-3.8A)
None
None
 0.89A 5esfA-3if2A:
undetectable		 5esfA-3if2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqx TAIL-ANCHORED
PROTEIN TARGETING
FACTOR GET3

(Chaetomium
thermophilum) 		PF02374
(ArsA_ATPase) 		4 PHE A 228
PHE A  31
THR A  63
LEU A  61
 None
 0.94A 5esfA-3iqxA:
undetectable		 5esfA-3iqxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 4 PHE D  31
ILE D  19
PHE D 179
THR D 233
 None
 0.82A 5esfA-3iz3D:
undetectable		 5esfA-3iz3D:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US19

(Plasmodium
falciparum) 		PF00203
(Ribosomal_S19) 		4 PHE X  37
ILE X 112
PHE X  45
LEU X  57
 None
 0.93A 5esfA-3j7aX:
undetectable		 5esfA-3j7aX:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		4 ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.85A 5esfA-3jr3A:
undetectable		 5esfA-3jr3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A  97
TYR A  83
GLY A  59
THR A  65
LEU A  67
 None
 1.46A 5esfA-3k6jA:
undetectable		 5esfA-3k6jA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl0 GLUCURONOXYLANASE
XYNC

(Bacillus
subtilis) 		PF17189
(Glyco_hydro_30C) 		4 ILE A 253
TYR A 265
PHE A  49
GLY A 287
 None
 0.92A 5esfA-3kl0A:
undetectable		 5esfA-3kl0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		4 TYR A 102
TYR A 115
THR A 294
LEU A 355
 HEM  A 481 (-4.7A)
HEM  A 481 ( 4.9A)
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.4A)
 0.57A 5esfA-3l4dA:
39.9		 5esfA-3l4dA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 189
ILE A 185
PHE A  74
THR A 164
 None
 0.92A 5esfA-3l8kA:
undetectable		 5esfA-3l8kA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 PHE A 589
ILE A 594
GLY A 243
THR A 229
 None
 0.84A 5esfA-3lppA:
undetectable		 5esfA-3lppA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o90 NICOTINAMIDASE

(Streptococcus
pneumoniae) 		PF00857
(Isochorismatase) 		4 TYR A 149
ILE A 151
THR A  51
LEU A 114
 None
 0.91A 5esfA-3o90A:
undetectable		 5esfA-3o90A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 PHE A 486
ILE A 485
PHE A 220
GLY A 246
 None
 0.89A 5esfA-3ombA:
undetectable		 5esfA-3ombA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		4 ILE A  71
GLY A  57
THR A 140
LEU A 137
 None
 0.88A 5esfA-3onqA:
undetectable		 5esfA-3onqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oss TYPE 2 SECRETION
SYSTEM, GSPC
TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD

(Escherichia
coli) 		PF03958
(Secretin_N)
PF11356
(T2SSC) 		4 TYR C 151
ILE C 167
GLY C 131
THR D  12
 None
 0.93A 5esfA-3ossC:
undetectable		 5esfA-3ossC:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 TYR A  43
ILE A  36
TYR A  40
GLY A  10
 None
None
None
NAD  A 333 (-2.9A)
 0.92A 5esfA-3pymA:
undetectable		 5esfA-3pymA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpc CUTINASE

(Fusarium solani) 		PF01083
(Cutinase) 		4 ILE A 130
TYR A 162
GLY A 117
LEU A 203
 None
 0.93A 5esfA-3qpcA:
undetectable		 5esfA-3qpcA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		4 PHE A  32
ILE A 424
TYR A 420
GLY A  16
 None
 0.86A 5esfA-3qt3A:
undetectable		 5esfA-3qt3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rap PROTEIN (G PROTEIN
RAP2A)

(Homo sapiens) 		PF00071
(Ras) 		4 ILE R  93
GLY R 115
THR R 145
LEU R 156
 None
 0.94A 5esfA-3rapR:
undetectable		 5esfA-3rapR:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Burkholderia
pseudomallei) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		4 ILE A 216
GLY A 192
THR A 177
LEU A 197
 None
 0.87A 5esfA-3tk8A:
undetectable		 5esfA-3tk8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 TYR A 626
TYR A 623
GLY A 787
LEU A 664
 None
 0.61A 5esfA-3tsyA:
undetectable		 5esfA-3tsyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbj GALACTOSIDE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 TYR A  69
ILE A  93
TYR A  90
GLY A 103
 None
 0.86A 5esfA-3vbjA:
undetectable		 5esfA-3vbjA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 TYR A  39
TYR A  36
GLY A 200
LEU A  77
 TYR  A  39 ( 1.3A)
TYR  A  36 ( 1.3A)
GLY  A 200 ( 0.0A)
LEU  A  77 ( 0.5A)
 0.88A 5esfA-3wd7A:
undetectable		 5esfA-3wd7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		4 TYR A  92
ILE A  90
GLY A 230
THR A  51
 None
 0.73A 5esfA-3x0vA:
undetectable		 5esfA-3x0vA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 TYR A 180
ILE A  52
TYR A 200
GLY A  55
THR A 339
 None
 1.46A 5esfA-3zbmA:
undetectable		 5esfA-3zbmA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		4 PHE A 100
PHE A  94
THR A 120
LEU A 118
 None
 0.92A 5esfA-4ayjA:
undetectable		 5esfA-4ayjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A 990
GLY A 948
THR A 904
LEU A 847
 None
 0.93A 5esfA-4c3hA:
undetectable		 5esfA-4c3hA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 ILE A 162
TYR A 221
PHE A 102
LEU A  49
 None
None
EDO  A1498 ( 4.7A)
None
 0.90A 5esfA-4c7gA:
undetectable		 5esfA-4c7gA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 PHE A 312
ILE A 356
GLY A 425
LEU A 399
 None
 0.77A 5esfA-4db1A:
0.8		 5esfA-4db1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		4 PHE A 342
ILE A 343
GLY A 354
LEU A 398
 None
 0.71A 5esfA-4effA:
undetectable		 5esfA-4effA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fay MICROCOMPARTMENTS
PROTEIN

(Lactobacillus
reuteri) 		PF00936
(BMC) 		5 ILE A 237
TYR A 236
GLY A 155
THR A 199
LEU A 146
 None
 1.49A 5esfA-4fayA:
undetectable		 5esfA-4fayA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyp VEGETATIVE STORAGE
PROTEIN 1

(Arabidopsis
thaliana) 		PF03767
(Acid_phosphat_B) 		4 TYR A  86
TYR A  82
GLY A  63
THR A  66
 None
 0.90A 5esfA-4fypA:
undetectable		 5esfA-4fypA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 PHE A 110
TYR A 116
THR A 295
LEU A 356
 VNT  A 502 (-4.4A)
HEM  A 501 ( 4.5A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
 0.93A 5esfA-4g3jA:
40.0		 5esfA-4g3jA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 PHE C  78
PHE C  95
GLY C 147
THR C 118
 None
 0.84A 5esfA-4g59C:
undetectable		 5esfA-4g59C:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbs PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF14064
(HmuY) 		4 TYR A 219
PHE A 215
ILE A 198
PHE A  43
 None
 0.92A 5esfA-4gbsA:
undetectable		 5esfA-4gbsA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 4 PHE A 160
TYR A 205
GLY A 220
LEU A 260
 None
 0.81A 5esfA-4gxbA:
undetectable		 5esfA-4gxbA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4has SORTING NEXIN-27

(Homo sapiens) 		PF00787
(PX) 		4 TYR A 251
ILE A 174
GLY A 262
LEU A 216
 None
 0.87A 5esfA-4hasA:
undetectable		 5esfA-4hasA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 432
GLY A 247
THR A 243
LEU A 443
 None
 0.88A 5esfA-4hjlA:
undetectable		 5esfA-4hjlA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084

(Cycloclasticus
sp. P1) 		PF12697
(Abhydrolase_6) 		5 PHE A  63
ILE A  60
PHE A 193
GLY A  33
LEU A 140
 None
None
None
CL  A 301 (-4.0A)
None
 1.23A 5esfA-4i3fA:
undetectable		 5esfA-4i3fA:
19.78