SIMILAR PATTERNS OF AMINO ACIDS FOR 5ESE_A_TPFA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		4 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.85A 5eseA-1a2oA:
0.0		 5eseA-1a2oA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akm ORNITHINE
TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 158
ILE A 212
GLY A 169
LEU A 137
 None
 0.75A 5eseA-1akmA:
0.1		 5eseA-1akmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpo PROTEIN (CLATHRIN)

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link)
PF13838
(Clathrin_H_link) 		4 LEU A 148
ILE A 170
GLY A 196
LEU A 166
 None
 0.77A 5eseA-1bpoA:
0.0		 5eseA-1bpoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.89A 5eseA-1c30A:
0.0		 5eseA-1c30A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		4 LEU A 148
ILE A 170
GLY A 196
LEU A 166
 None
 0.78A 5eseA-1c9lA:
0.0		 5eseA-1c9lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica) 		PF01339
(CheB_methylest) 		4 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.85A 5eseA-1chdA:
undetectable		 5eseA-1chdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cii COLICIN IA

(Escherichia
coli) 		PF01024
(Colicin)
PF11504
(Colicin_Ia) 		4 LEU A 604
PHE A 555
THR A 571
LEU A 583
 None
 0.84A 5eseA-1ciiA:
0.0		 5eseA-1ciiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckv PROTEIN (PROTEIN B)

(Escherichia
coli) 		PF02406
(MmoB_DmpM) 		4 LEU A  56
PHE A  51
ILE A  92
THR A 112
 None
 0.82A 5eseA-1ckvA:
0.0		 5eseA-1ckvA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dfx DESULFOFERRODOXIN

(Desulfovibrio
desulfuricans) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 TYR A   7
ILE A  15
GLY A 119
THR A  41
 None
 0.90A 5eseA-1dfxA:
0.0		 5eseA-1dfxA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpb DIHYDROLIPOYL-TRANSA
CETYLASE

(Azotobacter
vinelandii) 		PF00198
(2-oxoacid_dh) 		4 LEU A 477
PHE A 555
ILE A 503
LEU A 629
 None
 0.85A 5eseA-1dpbA:
undetectable		 5eseA-1dpbA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2y TRYPAREDOXIN
PEROXIDASE

(Crithidia
fasciculata) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A  41
ILE A 142
PHE A  43
GLY A 117
 None
 0.83A 5eseA-1e2yA:
undetectable		 5eseA-1e2yA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 LEU A 258
ILE A 300
PHE A 254
GLY A 318
 None
 0.87A 5eseA-1ff9A:
undetectable		 5eseA-1ff9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fts FTSY

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU A 210
PHE A 493
ILE A 489
PHE A 214
 None
 0.83A 5eseA-1ftsA:
undetectable		 5eseA-1ftsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		4 LEU A  65
ILE A  56
GLY A  17
LEU A 266
 None
 0.89A 5eseA-1g59A:
undetectable		 5eseA-1g59A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 TYR A 665
LEU A 705
ILE A 663
GLY A 701
 None
None
None
NA  A9001 (-4.8A)
 0.83A 5eseA-1h17A:
0.0		 5eseA-1h17A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbk CLPB PROTEIN

(Escherichia
coli) 		PF00004
(AAA) 		4 LEU A 299
PHE A 333
ILE A 323
GLY A 312
 None
 0.72A 5eseA-1jbkA:
undetectable		 5eseA-1jbkA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A 358
ILE A 314
PHE A 260
GLY A 365
THR A 368
 None
 1.40A 5eseA-1k0gA:
undetectable		 5eseA-1k0gA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		4 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.91A 5eseA-1l0qA:
undetectable		 5eseA-1l0qA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llc L-LACTATE
DEHYDROGENASE

(Lactobacillus
casei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 307
ILE A 281
PHE A 200
GLY A 193
THR A 165
 None
 1.00A 5eseA-1llcA:
undetectable		 5eseA-1llcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llc L-LACTATE
DEHYDROGENASE

(Lactobacillus
casei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 322
ILE A 281
GLY A 288
THR A 165
 None
 0.73A 5eseA-1llcA:
undetectable		 5eseA-1llcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR

(Haemophilus
influenzae) 		PF01467
(CTP_transf_like)
PF13521
(AAA_28) 		4 TYR A 181
LEU A 185
ILE A 169
PHE A 160
 None
 0.81A 5eseA-1lw7A:
undetectable		 5eseA-1lw7A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4x PBCV-1 VIRUS CAPSID

(Paramecium
bursaria
Chlorella virus
1) 		PF04451
(Capsid_NCLDV)
PF16903
(Capsid_N) 		4 LEU A  98
ILE A 228
GLY A 432
LEU A 168
 None
 0.90A 5eseA-1m4xA:
undetectable		 5eseA-1m4xA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrf REGULATORY PROTEIN
BLAR1

(Bacillus
licheniformis) 		PF00905
(Transpeptidase) 		4 LEU A 587
PHE A 567
PHE A 554
GLY A 538
 None
 0.86A 5eseA-1nrfA:
undetectable		 5eseA-1nrfA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrf REGULATORY PROTEIN
BLAR1

(Bacillus
licheniformis) 		PF00905
(Transpeptidase) 		4 TYR A 596
LEU A 587
PHE A 554
GLY A 556
 None
 0.87A 5eseA-1nrfA:
undetectable		 5eseA-1nrfA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojl TRANSCRIPTIONAL
REGULATORY PROTEIN
ZRAR

(Salmonella
enterica) 		PF00158
(Sigma54_activat)
PF02954
(HTH_8) 		5 LEU A 298
PHE A 294
GLY A 243
THR A 281
LEU A 166
 None
 1.48A 5eseA-1ojlA:
undetectable		 5eseA-1ojlA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 110
PHE A  77
ILE A  62
PHE A 101
LEU A  93
 None
 1.42A 5eseA-1oznA:
undetectable		 5eseA-1oznA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 384
ILE A 452
GLY A 390
LEU A 428
 None
 0.90A 5eseA-1pcgA:
0.7		 5eseA-1pcgA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q18 GLUCOKINASE

(Escherichia
coli) 		PF02685
(Glucokinase) 		4 LEU A  95
ILE A  98
GLY A   8
LEU A  41
 None
 0.84A 5eseA-1q18A:
0.6		 5eseA-1q18A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmv PEROXIREDOXIN-2

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A  40
ILE A 141
PHE A  42
GLY A 116
 None
 0.79A 5eseA-1qmvA:
undetectable		 5eseA-1qmvA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 LEU A 320
ILE A 342
PHE A 311
LEU A 254
 None
 0.83A 5eseA-1r5nA:
undetectable		 5eseA-1r5nA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc6 HYPOTHETICAL PROTEIN
YLBA

(Escherichia
coli) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		5 TYR A1251
LEU A1184
ILE A1206
PHE A1186
GLY A1238
 None
 1.45A 5eseA-1rc6A:
undetectable		 5eseA-1rc6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc6 HYPOTHETICAL PROTEIN
YLBA

(Escherichia
coli) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		5 TYR A1251
LEU A1184
PHE A1247
ILE A1206
GLY A1238
 None
 1.35A 5eseA-1rc6A:
undetectable		 5eseA-1rc6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 114
PHE A  19
ILE A  18
LEU A 187
 None
 0.77A 5eseA-1re5A:
undetectable		 5eseA-1re5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rni ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol) 		4 LEU A 182
PHE A  50
ILE A 100
THR A 134
 None
 0.87A 5eseA-1rniA:
undetectable		 5eseA-1rniA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtg HUMAN GELATINASE A

(Homo sapiens) 		PF00045
(Hemopexin) 		4 LEU A 516
PHE A 488
ILE A 493
PHE A 534
 None
 0.76A 5eseA-1rtgA:
undetectable		 5eseA-1rtgA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE

(Mycobacterium
bovis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		4 ILE A 177
GLY A 153
THR A 138
LEU A 158
 None
 0.87A 5eseA-1tdtA:
1.6		 5eseA-1tdtA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		4 ILE A 210
GLY A 213
THR A 216
LEU A 184
 None
 0.87A 5eseA-1tisA:
undetectable		 5eseA-1tisA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut1 DR HEMAGGLUTININ
STRUCTURAL SUBUNIT

(Escherichia
coli) 		PF04619
(Adhesin_Dr) 		4 LEU A  35
GLY A  42
THR A  11
LEU A  72
 None
 0.88A 5eseA-1ut1A:
undetectable		 5eseA-1ut1A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 LEU C 269
PHE C 288
GLY C 234
LEU C 182
 None
 0.79A 5eseA-1wa5C:
undetectable		 5eseA-1wa5C:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgk RIKEN CDNA
2900073H19 PROTEIN

(Mus musculus) 		PF09138
(Urm1) 		4 LEU A  56
PHE A  64
ILE A  65
PHE A  18
 None
 0.81A 5eseA-1wgkA:
undetectable		 5eseA-1wgkA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 PHE A  41
ILE A  21
GLY A 262
LEU A 214
 None
 0.84A 5eseA-1womA:
undetectable		 5eseA-1womA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyj PROTOCADHERIN BETA
14

(Mus musculus) 		PF08266
(Cadherin_2) 		5 LEU A  92
ILE A  48
GLY A 101
THR A  12
LEU A  34
 None
 1.36A 5eseA-1wyjA:
undetectable		 5eseA-1wyjA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 TYR A  76
PHE A  83
THR A 260
LEU A 321
 ESL  A 471 ( 3.8A)
None
HEM  A 470 (-3.6A)
HEM  A 470 (-4.1A)
 0.90A 5eseA-1x8vA:
35.6		 5eseA-1x8vA:
28.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		4 LEU A  80
PHE A 106
ILE A  73
GLY A   6
 None
 0.89A 5eseA-1xmxA:
undetectable		 5eseA-1xmxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
FGFR SIGNALLING
ADAPTOR SNT-1

(Homo sapiens) 		PF02174
(IRS)
no annotation 		4 LEU B  71
ILE B  24
GLY B  30
LEU A 417
 None
 0.90A 5eseA-1xr0B:
undetectable		 5eseA-1xr0B:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		4 LEU A  89
PHE A  26
ILE A  41
PHE A 152
 None
 0.82A 5eseA-1xwwA:
undetectable		 5eseA-1xwwA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 LEU A 240
PHE A 205
ILE A 216
LEU A 148
 None
 0.89A 5eseA-1ycnA:
undetectable		 5eseA-1ycnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		5 LEU A  88
PHE A  80
ILE A  49
PHE A 118
THR A 136
 None
 1.40A 5eseA-1ye8A:
undetectable		 5eseA-1ye8A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2

(Archaeoglobus
fulgidus) 		PF02552
(CO_dh) 		4 LEU A 113
PHE A 153
GLY A  25
LEU A 174
 None
 0.86A 5eseA-1ytlA:
undetectable		 5eseA-1ytlA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 LEU A 405
ILE A 416
GLY A 582
LEU A  65
 None
 0.89A 5eseA-1z8lA:
undetectable		 5eseA-1z8lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		4 TYR A  14
LEU A   7
ILE A  30
LEU A 311
 None
None
A70  A 500 (-4.3A)
None
 0.87A 5eseA-1zapA:
undetectable		 5eseA-1zapA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a22 VACUOLAR PROTEIN
SORTING 29

(Cryptosporidium
parvum) 		PF12850
(Metallophos_2) 		4 LEU A  10
ILE A  64
THR A 151
LEU A  24
 None
 0.89A 5eseA-2a22A:
undetectable		 5eseA-2a22A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU X 137
ILE X   7
PHE X  45
THR X  37
 None
 0.89A 5eseA-2b5dX:
undetectable		 5eseA-2b5dX:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 LEU A 710
ILE A 389
GLY A 373
LEU A1029
 None
 0.87A 5eseA-2b5mA:
undetectable		 5eseA-2b5mA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB

(Thermococcus
kodakarensis) 		PF08423
(Rad51) 		4 LEU A  22
ILE A 179
THR A 115
LEU A 131
 None
 0.78A 5eseA-2cvhA:
undetectable		 5eseA-2cvhA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 TYR A 333
LEU A 288
PHE A 275
THR A 206
 None
 0.88A 5eseA-2dwsA:
undetectable		 5eseA-2dwsA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 ILE X 618
GLY X 342
THR X 344
LEU X 495
 None
 0.89A 5eseA-2epkX:
undetectable		 5eseA-2epkX:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eve HYPOTHETICAL PROTEIN
PSPTO5229

(Pseudomonas
syringae group
genomosp. 3) 		PF01878
(EVE) 		4 LEU A 109
PHE A  48
ILE A  62
LEU A 150
 None
 0.86A 5eseA-2eveA:
undetectable		 5eseA-2eveA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 TYR A  88
LEU A  39
GLY A 384
LEU A 405
 None
 0.85A 5eseA-2g02A:
undetectable		 5eseA-2g02A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 LEU A 335
ILE A 386
GLY A 391
THR A 426
 None
 0.73A 5eseA-2gq3A:
undetectable		 5eseA-2gq3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtp REGULATOR OF
G-PROTEIN SIGNALING
1

(Homo sapiens) 		PF00615
(RGS) 		4 PHE C 177
ILE C 182
GLY C  82
LEU C  61
 None
 0.87A 5eseA-2gtpC:
1.3		 5eseA-2gtpC:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		4 LEU A   6
PHE A  87
ILE A 226
PHE A 268
 None
 0.83A 5eseA-2h1yA:
undetectable		 5eseA-2h1yA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 TYR A 548
LEU A 273
PHE A 541
GLY A  49
THR A  24
 None
 1.44A 5eseA-2hnhA:
0.1		 5eseA-2hnhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
pneumoniae) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 247
ILE A 257
THR A 240
LEU A 135
 None
 0.88A 5eseA-2ho5A:
undetectable		 5eseA-2ho5A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 322
PHE A 292
ILE A 277
PHE A 316
LEU A 327
 None
 1.33A 5eseA-2id5A:
undetectable		 5eseA-2id5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		4 TYR A 150
PHE A 143
ILE A 146
PHE A 120
 None
 0.90A 5eseA-2ip1A:
0.0		 5eseA-2ip1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU A 287
PHE A   2
GLY A 254
LEU A 244
 DIO  A 800 ( 4.0A)
None
None
None
 0.84A 5eseA-2ng1A:
undetectable		 5eseA-2ng1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 LEU A 804
PHE A 782
ILE A 781
THR A 762
 None
 0.65A 5eseA-2nztA:
undetectable		 5eseA-2nztA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o08 BH1327 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		5 TYR A 128
LEU A 125
GLY A 112
THR A 178
LEU A 157
 None
 1.37A 5eseA-2o08A:
undetectable		 5eseA-2o08A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6r VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A  80
ILE A  35
PHE A  71
LEU A  63
 None
 0.88A 5eseA-2o6rA:
undetectable		 5eseA-2o6rA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.74A 5eseA-2o7rA:
undetectable		 5eseA-2o7rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 110
ILE A  75
PHE A 322
GLY A 289
LEU A 279
 None
 1.46A 5eseA-2og2A:
undetectable		 5eseA-2og2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozj CUPIN 2, CONSERVED
BARREL

(Desulfitobacterium
hafniense) 		no annotation 4 TYR A  61
ILE A  63
PHE A  44
GLY A  97
 None
 0.90A 5eseA-2ozjA:
undetectable		 5eseA-2ozjA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4u ACID PHOSPHATASE 1

(Mus musculus) 		PF01451
(LMWPc) 		4 LEU A  90
PHE A  27
ILE A  42
PHE A 153
 None
 0.75A 5eseA-2p4uA:
undetectable		 5eseA-2p4uA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5t PEZT

(Streptococcus
pneumoniae) 		PF06414
(Zeta_toxin) 		4 LEU B 140
ILE B  48
GLY B  39
LEU B 224
 None
 0.88A 5eseA-2p5tB:
undetectable		 5eseA-2p5tB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN

(Desulfotalea
psychrophila) 		PF02634
(FdhD-NarQ) 		5 TYR A 126
LEU A 128
ILE A 214
PHE A 136
GLY A 157
 None
 1.36A 5eseA-2pw9A:
1.2		 5eseA-2pw9A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q34 CURF

(Moorea
producens) 		PF00378
(ECH_1) 		4 LEU A 101
PHE A 229
GLY A 150
THR A 152
 None
 0.69A 5eseA-2q34A:
undetectable		 5eseA-2q34A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qoj INTRON-ENCODED DNA
ENDONUCLEASE I-ANII

(Aspergillus
nidulans) 		PF00961
(LAGLIDADG_1) 		4 LEU Z 177
PHE Z 137
ILE Z 132
LEU Z 201
 None
 0.90A 5eseA-2qojZ:
undetectable		 5eseA-2qojZ:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 LEU A 189
PHE A 392
ILE A 184
PHE A 216
GLY A 179
 None
 1.15A 5eseA-2qxlA:
undetectable		 5eseA-2qxlA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 TYR A 315
LEU A 318
ILE A 304
PHE A 372
 None
 0.90A 5eseA-2r6fA:
undetectable		 5eseA-2r6fA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli) 		PF00154
(RecA) 		4 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
 0.83A 5eseA-2rebA:
undetectable		 5eseA-2rebA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		4 TYR A 556
PHE A 534
ILE A 537
GLY A 509
 None
 0.81A 5eseA-2rfoA:
undetectable		 5eseA-2rfoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 716
GLY A 618
THR A 657
LEU A 654
 None
 0.79A 5eseA-2v9yA:
undetectable		 5eseA-2v9yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE

(Pseudomonas
fluorescens) 		PF00378
(ECH_1) 		4 LEU C 102
GLY C 121
THR C  67
LEU C  24
 None
 0.91A 5eseA-2vsuC:
undetectable		 5eseA-2vsuC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 LEU A 272
ILE A 308
GLY A 389
LEU A 165
 None
 0.70A 5eseA-2vz9A:
undetectable		 5eseA-2vz9A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 ILE A 260
PHE A 208
GLY A 210
LEU A 219
 None
 0.87A 5eseA-2wedA:
undetectable		 5eseA-2wedA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Neisseria
meningitidis) 		PF00132
(Hexapep) 		4 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.79A 5eseA-2wlcA:
undetectable		 5eseA-2wlcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU B 373
PHE B 379
PHE B 355
THR B 268
 None
 0.87A 5eseA-2wtkB:
undetectable		 5eseA-2wtkB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF03308
(ArgK) 		4 LEU A 148
ILE A 238
PHE A 159
LEU A 285
 None
 0.86A 5eseA-2wwwA:
undetectable		 5eseA-2wwwA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 485
PHE A 489
THR A 275
LEU A 301
 None
 0.86A 5eseA-2xgtA:
undetectable		 5eseA-2xgtA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 114
PHE A 126
GLY A  63
LEU A 324
 None
 0.89A 5eseA-2xn6A:
undetectable		 5eseA-2xn6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y38 LAMININ SUBUNIT
ALPHA-5

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 LEU A 325
PHE A  55
GLY A 303
LEU A 153
 None
 0.86A 5eseA-2y38A:
undetectable		 5eseA-2y38A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 TYR A  11
LEU A  14
ILE A  77
GLY A 173
 None
 0.76A 5eseA-2ywbA:
undetectable		 5eseA-2ywbA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		4 LEU A 235
PHE A 263
GLY A 181
THR A 185
 None
 0.81A 5eseA-2yzsA:
undetectable		 5eseA-2yzsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A  80
ILE A  35
PHE A  71
LEU A  63
 None
 0.72A 5eseA-2z66A:
undetectable		 5eseA-2z66A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 LEU A 403
ILE A 341
GLY A  44
LEU A 388
 None
 0.72A 5eseA-2zktA:
undetectable		 5eseA-2zktA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 LEU A 379
ILE A 629
GLY A 614
LEU A 660
 None
 0.87A 5eseA-2zwaA:
undetectable		 5eseA-2zwaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 TYR A 357
ILE A 381
GLY A 421
LEU A 261
 None
GOL  A 915 (-4.7A)
None
None
 0.89A 5eseA-3a21A:
undetectable		 5eseA-3a21A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU B 178
PHE B 209
ILE B 228
PHE B 241
LEU B 199
 None
 1.39A 5eseA-3a79B:
undetectable		 5eseA-3a79B:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be8 NEUROLIGIN-4,
X-LINKED

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 132
ILE A 185
PHE A 128
GLY A 174
LEU A 205
 None
None
None
PO4  A 623 ( 3.6A)
None
 1.03A 5eseA-3be8A:
undetectable		 5eseA-3be8A:
22.91