SIMILAR PATTERNS OF AMINO ACIDS FOR 5ERO_C_210C804

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ASP A 351
ASP A 352
ARG A 314
ASP A 496
ASP A 497
 MG  A 703 (-2.4A)
None
3AG  A 900 (-3.0A)
MG  A 702 ( 2.6A)
None
 0.80A 5eroC-1n21A:
11.3		 5eroC-1n21A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ASP A 355
ASP A 352
ARG A 314
ASP A 496
ASP A 497
 MG  A 703 (-2.7A)
None
3AG  A 900 (-3.0A)
MG  A 702 ( 2.6A)
None
 1.36A 5eroC-1n21A:
11.3		 5eroC-1n21A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ASP A 355
ASP A 509
ARG A 314
ASP A 496
ASP A 497
 MG  A 703 (-2.7A)
MG  A 701 ( 4.4A)
3AG  A 900 (-3.0A)
MG  A 702 ( 2.6A)
None
 1.16A 5eroC-1n21A:
11.3		 5eroC-1n21A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		8 ASP A 105
ASP A 106
ASP A 111
ARG A 116
LYS A 202
GLN A 241
ASP A 244
ASP A 245
 MG  A 907 (-2.5A)
None
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 0.69A 5eroC-1rqjA:
26.3		 5eroC-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		7 ASP A 105
ASP A 111
ARG A 116
LYS A 202
GLN A 241
ASP A 245
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
None
RIS  A 901 (-2.7A)
 1.09A 5eroC-1rqjA:
26.3		 5eroC-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		6 ASP A 111
ASP A 106
ARG A 116
GLN A 241
ASP A 244
ASP A 245
 MG  A 909 (-2.4A)
None
RIS  A 901 (-2.7A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 1.30A 5eroC-1rqjA:
26.3		 5eroC-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 ASP A 111
ASP A 113
GLN A 241
ASP A 244
ASP A 245
 MG  A 909 (-2.4A)
MG  A 907 ( 4.9A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 1.08A 5eroC-1rqjA:
26.3		 5eroC-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		6 ASP A 113
ASP A 111
LYS A 202
GLN A 241
ASP A 244
ASP A 245
 MG  A 907 ( 4.9A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 1.46A 5eroC-1rqjA:
26.3		 5eroC-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 ASP A  79
ASP A  80
ASP A  83
ARG A  88
GLN A 209
 None
 1.09A 5eroC-1wmwA:
28.6		 5eroC-1wmwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 ASP A  80
ARG A  88
GLN A 209
ASP A 212
ASP A 213
 None
 0.83A 5eroC-1wmwA:
28.6		 5eroC-1wmwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 ASP A  80
ASP A  83
ARG A  88
GLN A 209
ASP A 213
 None
 0.68A 5eroC-1wmwA:
28.6		 5eroC-1wmwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 ASP A  83
ASP A  80
ARG A  88
GLN A 209
ASP A 213
 None
 1.34A 5eroC-1wmwA:
28.6		 5eroC-1wmwA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 ASP A  87
ASP A  90
ARG A  95
GLN A 215
LYS A 242
 None
 0.90A 5eroC-1wy0A:
26.1		 5eroC-1wy0A:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		6 ASP A  82
ASP A  85
ARG A  90
GLN A 197
ASP A 200
ASP A 201
 None
 0.94A 5eroC-2azkA:
22.2		 5eroC-2azkA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		6 ASP A  82
ASP A  85
ARG A  90
LYS A 160
GLN A 197
ASP A 200
 None
 1.38A 5eroC-2azkA:
22.2		 5eroC-2azkA:
27.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		8 ASP A  80
ASP A  81
ASP A  84
ARG A  89
LYS A 174
GLN A 211
ASP A 214
ASP A 215
 MG  A 341 (-2.6A)
None
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.64A 5eroC-2dh4A:
32.2		 5eroC-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		5 ASP A  80
ASP A  84
LYS A 174
GLN A 211
ASP A 214
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
None
 1.40A 5eroC-2dh4A:
32.2		 5eroC-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		6 ASP A  80
ASP A  84
LYS A 174
GLN A 211
ASP A 215
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
None
MG  A 341 ( 4.6A)
 0.92A 5eroC-2dh4A:
32.2		 5eroC-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		6 ASP A  84
ASP A  81
ARG A  89
GLN A 211
ASP A 214
ASP A 215
 MG  A 341 (-3.0A)
None
MG  A 341 ( 4.6A)
None
None
None
 1.36A 5eroC-2dh4A:
32.2		 5eroC-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		5 ASP A 214
ASP A 215
ASP A  80
ASP A  81
LYS A 238
 None
None
MG  A 341 (-2.6A)
None
MG  A 341 ( 4.6A)
 0.80A 5eroC-2dh4A:
32.2		 5eroC-2dh4A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		7 ASP A 115
ASP A 116
ASP A 119
ARG A 124
LYS A 210
GLN A 251
ASP A 255
 MG  A 503 (-2.5A)
None
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
None
 0.63A 5eroC-2o1oA:
24.7		 5eroC-2o1oA:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		9 ASP A  64
ASP A  65
ASP A  68
ARG A  73
LYS A 151
GLN A 185
ASP A 188
ASP A 189
LYS A 202
 GRG  A 500 (-2.4A)
None
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
None
GRG  A 500 ( 2.6A)
 0.83A 5eroC-2q80A:
34.9		 5eroC-2q80A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		7 ASP A  64
ASP A  65
ASP A  68
LYS A 151
GLN A 185
ASP A 188
LYS A 212
 GRG  A 500 (-2.4A)
None
MG  A 400 (-2.6A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
GRG  A 500 (-2.8A)
 0.68A 5eroC-2q80A:
34.9		 5eroC-2q80A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 ASP A  68
ASP A  65
ARG A  73
GLN A 185
ASP A 189
LYS A 202
 MG  A 400 (-2.6A)
None
GRG  A 500 (-2.9A)
GRG  A 500 (-3.2A)
None
GRG  A 500 ( 2.6A)
 1.33A 5eroC-2q80A:
34.9		 5eroC-2q80A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 ASP A 188
ASP A 189
ASP A  64
ASP A  65
LYS A 212
 GRG  A 500 (-3.5A)
None
GRG  A 500 (-2.4A)
None
GRG  A 500 (-2.8A)
 0.63A 5eroC-2q80A:
34.9		 5eroC-2q80A:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 ASP B  84
ASP B  85
ASP B  88
ARG B  93
ASP B 230
 MG  B 326 (-2.6A)
MG  B 326 ( 4.8A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
MG  B 328 ( 3.6A)
 1.09A 5eroC-3aqcB:
27.0		 5eroC-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 ASP B  84
ASP B  85
ASP B  88
LYS B 170
ASP B 230
 MG  B 326 (-2.6A)
MG  B 326 ( 4.8A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
MG  B 328 ( 3.6A)
 1.39A 5eroC-3aqcB:
27.0		 5eroC-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 ASP B  85
ASP B  88
ARG B  93
GLN B 208
ASP B 211
 MG  B 326 ( 4.8A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
MG  B 328 (-3.1A)
 1.02A 5eroC-3aqcB:
27.0		 5eroC-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 ASP A  89
ASP A 163
GLN A 221
ASP A 224
ASP A 225
 None
 1.38A 5eroC-3m9uA:
23.4		 5eroC-3m9uA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ASP A 345
ASP A 346
ASP A 349
ARG A 308
ASP A 490
 MG  A 623 (-3.0A)
None
MG  A 623 ( 3.2A)
DST  A 601 (-4.1A)
MG  A 622 ( 4.5A)
 1.18A 5eroC-3n0gA:
9.7		 5eroC-3n0gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 ASP A  83
ASP A  84
ASP A  89
ARG A  94
LYS A 180
 MG  A 297 (-2.5A)
None
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
 0.75A 5eroC-3p41A:
21.9		 5eroC-3p41A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		7 ASP A  92
ASP A  93
ASP A  98
ARG A 103
GLN A 225
ASP A 228
ASP A 229
 MG  A 400 ( 2.8A)
None
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
None
 0.75A 5eroC-3q1oA:
24.6		 5eroC-3q1oA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		7 ASP A  92
ASP A  93
ASP A  98
LYS A 186
GLN A 225
ASP A 228
ASP A 229
 MG  A 400 ( 2.8A)
None
MG  A 400 ( 3.2A)
DMA  A 501 (-3.1A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
None
 0.61A 5eroC-3q1oA:
24.6		 5eroC-3q1oA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 ASP A  92
ASP A  98
ARG A 103
ASP A 229
LYS A 242
 MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
None
DMA  A 501 (-2.7A)
 1.29A 5eroC-3q1oA:
24.6		 5eroC-3q1oA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 ASP A  92
ASP A  98
LYS A 186
GLN A 225
ASP A 228
 MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.1A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
 1.47A 5eroC-3q1oA:
24.6		 5eroC-3q1oA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		6 ASP A  98
ASP A  93
ARG A 103
GLN A 225
ASP A 228
ASP A 229
 MG  A 400 ( 3.2A)
None
DMA  A 501 (-3.0A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
None
 1.39A 5eroC-3q1oA:
24.6		 5eroC-3q1oA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		7 ASP A 108
ASP A 109
ASP A 112
ARG A 117
LYS A 215
GLN A 254
LYS A 271
 MG  A 381 (-2.4A)
None
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
DMA  A 384 ( 2.8A)
 0.88A 5eroC-3qqvA:
27.7		 5eroC-3qqvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		6 ASP A 108
ASP A 109
ASP A 112
LYS A 215
GLN A 254
LYS A 281
 MG  A 381 (-2.4A)
None
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
DMA  A 384 (-2.4A)
 0.79A 5eroC-3qqvA:
27.7		 5eroC-3qqvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		7 ASP A 109
ASP A 112
ARG A 117
LYS A 215
GLN A 254
ASP A 258
LYS A 271
 None
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
None
DMA  A 384 ( 2.8A)
 0.93A 5eroC-3qqvA:
27.7		 5eroC-3qqvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		6 ASP A 109
ASP A 112
LYS A 215
GLN A 254
ASP A 258
LYS A 281
 None
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
None
DMA  A 384 (-2.4A)
 0.97A 5eroC-3qqvA:
27.7		 5eroC-3qqvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		5 ASP A  88
ASP A  89
ASP A  94
ARG A  99
LYS A 185
 None
 1.15A 5eroC-3ts7A:
22.6		 5eroC-3ts7A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 ASP A  84
ASP A  85
ASP A  88
ARG A  93
ASP A 230
 IPE  A 401 (-2.6A)
None
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
None
 0.78A 5eroC-3wjoA:
25.1		 5eroC-3wjoA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		5 ASP A  83
ASP A  84
ASP A  89
ARG A  94
LYS A 180
 MG  A1295 (-2.5A)
None
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
 0.67A 5eroC-3zouA:
21.5		 5eroC-3zouA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 ASP A 530
ASP A 527
ARG A 523
ASP A 279
ASP A 253
 MG  A1771 ( 4.1A)
None
None
MG  A1768 ( 4.3A)
MG  A1767 (-2.4A)
 1.10A 5eroC-4a01A:
2.3		 5eroC-4a01A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		8 ASP A  98
ASP A  99
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
ASP A 251
 MG  A 403 (-2.5A)
None
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
None
 0.63A 5eroC-4e1eA:
27.0		 5eroC-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		7 ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 251
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
None
0MW  A 404 ( 3.0A)
 1.00A 5eroC-4e1eA:
27.0		 5eroC-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		5 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 1.45A 5eroC-4e1eA:
27.0		 5eroC-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		6 ASP A 102
ASP A  99
ARG A 107
GLN A 247
ASP A 250
ASP A 251
 MG  A 403 (-2.4A)
None
0MW  A 404 (-2.7A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
None
 1.37A 5eroC-4e1eA:
27.0		 5eroC-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ASP A  85
ASP A  86
ASP A  89
ARG A  94
LYS A 184
 None
 0.78A 5eroC-4gp1A:
24.0		 5eroC-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		7 ASP A  98
ASP A  99
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
None
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.62A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		5 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 1.39A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		7 ASP A  99
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
ASP A 251
 None
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
None
 0.72A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		5 ASP A 102
ARG A 107
LYS A 207
ASP A 251
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
None
476  A 402 (-2.9A)
 1.27A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		5 ASP A 102
ASP A  99
ARG A 107
ASP A 250
ASP A 251
 CA  A 403 (-2.5A)
None
476  A 402 (-2.9A)
CA  A 404 (-3.0A)
None
 1.48A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ASP A  87
ASP A  92
ARG A  97
LYS A 184
 None
 0.94A 5eroC-4kkmA:
22.8		 5eroC-4kkmA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 ARG A  89
LYS A 172
GLN A 210
ASP A 213
ASP A 214
 IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 1.12A 5eroC-4lfeA:
24.4		 5eroC-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 ASP A  78
ASP A  79
ASP A  84
ARG A  89
LYS A 172
 MG  A 302 (-2.5A)
None
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
 0.84A 5eroC-4lfeA:
24.4		 5eroC-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ASP A  80
ASP A  81
ASP A  86
ARG A  91
ASP A 235
 CA  A 304 ( 2.9A)
None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
CA  A 303 ( 4.3A)
 1.07A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		6 ASP A  80
ASP A  81
ASP A  86
ARG A  91
LYS A 178
ASP A 216
 CA  A 304 ( 2.9A)
None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
 0.69A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		6 ASP A  81
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.79A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ARG A  91
LYS A 178
GLN A 213
LYS A 230
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
GST  A 302 (-2.7A)
 1.28A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		8 ASP A 103
ASP A 104
ASP A 107
ARG A 112
LYS A 200
GLN A 240
ASP A 243
ASP A 244
 MG  A 405 (-2.5A)
None
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
None
 0.58A 5eroC-4p0vA:
27.3		 5eroC-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		7 ASP A 103
ASP A 107
ARG A 112
LYS A 200
GLN A 240
ASP A 244
LYS A 257
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
None
1WO  A 402 ( 2.8A)
 0.98A 5eroC-4p0vA:
27.3		 5eroC-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 ASP A 103
ASP A 107
LYS A 200
GLN A 240
ASP A 243
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
 1.39A 5eroC-4p0vA:
27.3		 5eroC-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 ASP A 107
ASP A 104
ARG A 112
GLN A 240
ASP A 243
ASP A 244
 MG  A 405 (-2.4A)
None
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
None
 1.37A 5eroC-4p0vA:
27.3		 5eroC-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		9 ASP A 103
ASP A 104
ASP A 107
ARG A 112
LYS A 212
GLN A 252
ASP A 255
ASP A 256
LYS A 269
 MG  A3004 (-2.5A)
MG  A3002 (-4.6A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
None
3YQ  A3001 (-3.1A)
 0.72A 5eroC-4rxeA:
27.0		 5eroC-4rxeA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		7 ASP A 107
ASP A 104
ARG A 112
GLN A 252
ASP A 255
ASP A 256
LYS A 269
 MG  A3004 (-2.3A)
MG  A3002 (-4.6A)
3YQ  A3001 (-2.8A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
None
3YQ  A3001 (-3.1A)
 1.24A 5eroC-4rxeA:
27.0		 5eroC-4rxeA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		6 ASP A  75
ASP A  80
ARG A  85
LYS A 163
GLN A 198
ASP A 201
 None
 1.20A 5eroC-4wk5A:
23.8		 5eroC-4wk5A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		8 ASP B 103
ASP B 104
ASP B 107
ARG B 112
LYS B 212
GLN B 252
ASP B 255
ASP B 256
 MG  B1370 (-2.5A)
G76  B1368 ( 4.7A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
None
 0.55A 5eroC-5ahuB:
23.9		 5eroC-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		7 ASP B 103
ASP B 107
ARG B 112
LYS B 212
GLN B 252
ASP B 256
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
None
G76  B1368 (-3.1A)
 0.93A 5eroC-5ahuB:
23.9		 5eroC-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		5 ASP B 103
ASP B 107
LYS B 212
GLN B 252
ASP B 255
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
 1.49A 5eroC-5ahuB:
23.9		 5eroC-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 ASP B 107
ASP B 104
ARG B 112
GLN B 252
ASP B 255
ASP B 256
 MG  B1369 (-2.2A)
G76  B1368 ( 4.7A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
None
 1.29A 5eroC-5ahuB:
23.9		 5eroC-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ASP A  87
ASP A  92
ARG A  97
LYS A 183
 None
 0.76A 5eroC-5aypA:
20.5		 5eroC-5aypA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b01 MOEN5

(Streptomyces
viridosporus) 		no annotation 5 ASP A 185
ASP A 186
ASP A 189
ASP A  70
ASP A  71
 None
 1.04A 5eroC-5b01A:
13.7		 5eroC-5b01A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		5 ARG A 135
LYS A 243
GLN A 284
ASP A 288
LYS A 301
 04M  A 401 (-3.5A)
04M  A 401 (-4.5A)
None
None
04M  A 401 ( 3.9A)
 1.23A 5eroC-5hn7A:
27.4		 5eroC-5hn7A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		5 ASP A 126
ARG A 135
LYS A 243
GLN A 284
LYS A 301
 04M  A 401 ( 4.0A)
04M  A 401 (-3.5A)
04M  A 401 (-4.5A)
None
04M  A 401 ( 3.9A)
 1.30A 5eroC-5hn7A:
27.4		 5eroC-5hn7A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		7 ASP A 126
ASP A 127
ASP A 130
ARG A 135
LYS A 243
GLN A 284
ASP A 287
 04M  A 401 ( 4.0A)
None
None
04M  A 401 (-3.5A)
04M  A 401 (-4.5A)
None
None
 0.74A 5eroC-5hn7A:
27.4		 5eroC-5hn7A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		7 ASP A 127
ASP A 130
ARG A 135
LYS A 243
GLN A 284
ASP A 287
ASP A 288
 None
None
04M  A 401 (-3.5A)
04M  A 401 (-4.5A)
None
None
None
 0.78A 5eroC-5hn7A:
27.4		 5eroC-5hn7A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ASP A 343
ASP A 344
ASP A 347
ASP A 488
ASP A 489
 MN  A 702 (-2.7A)
None
MN  A 701 (-2.7A)
MN  A 703 ( 2.8A)
None
 1.09A 5eroC-5uv2A:
13.8		 5eroC-5uv2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 8 ASP A 147
ASP A 148
ASP A 151
ARG A 156
LYS A 244
GLN A 284
ASP A 287
ASP A 288
 MG  A 402 (-2.6A)
None
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
None
 0.62A 5eroC-6b07A:
27.3		 5eroC-6b07A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 8 ASP A 147
ASP A 151
ARG A 156
LYS A 244
GLN A 284
ASP A 287
ASP A 288
LYS A 301
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
None
C6M  A 401 (-2.9A)
 0.94A 5eroC-6b07A:
27.3		 5eroC-6b07A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 ASP A 147
ASP A 151
LYS A 244
GLN A 284
ASP A 287
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
 1.47A 5eroC-6b07A:
27.3		 5eroC-6b07A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 ASP A 147
GLN A 284
ASP A 287
ASP A 288
LYS A 301
 MG  A 402 (-2.6A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
None
C6M  A 401 (-2.9A)
 1.32A 5eroC-6b07A:
27.3		 5eroC-6b07A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 6 ASP A 151
ASP A 148
ARG A 156
GLN A 284
ASP A 287
ASP A 288
 MG  A 402 (-2.5A)
None
C6M  A 401 (-2.7A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
None
 1.33A 5eroC-6b07A:
27.3		 5eroC-6b07A:
11.69