SIMILAR PATTERNS OF AMINO ACIDS FOR 5ERO_B_210B804

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ASP A 355
ASP A 509
ARG A 314
ASP A 496
ASP A 497
 MG  A 703 (-2.7A)
MG  A 701 ( 4.4A)
3AG  A 900 (-3.0A)
MG  A 702 ( 2.6A)
None
 1.14A 5eroB-1n21A:
10.0		 5eroB-1n21A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 ASP A 105
ARG A 116
LYS A 202
ASP A 245
LYS A 258
 MG  A 907 (-2.5A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
None
RIS  A 901 (-2.7A)
 1.43A 5eroB-1rqjA:
26.3		 5eroB-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		7 ASP A 105
ASP A 111
ARG A 116
LYS A 202
GLN A 241
ASP A 244
ASP A 245
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 0.64A 5eroB-1rqjA:
26.3		 5eroB-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 ASP A 111
ARG A 116
GLN A 241
ASP A 244
ASP A 245
 MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 1.26A 5eroB-1rqjA:
26.3		 5eroB-1rqjA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		8 ASP A  80
ASP A  84
ARG A  89
LYS A 174
GLN A 211
ASP A 214
ASP A 215
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
MG  A 341 ( 4.6A)
 0.55A 5eroB-2dh4A:
32.2		 5eroB-2dh4A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		5 ASP A  84
ARG A  89
GLN A 211
ASP A 214
ASP A 215
 MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
 1.29A 5eroB-2dh4A:
32.2		 5eroB-2dh4A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		6 ASP A 115
ASP A 119
ARG A 124
LYS A 210
GLN A 251
ASP A 255
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
None
 0.57A 5eroB-2o1oA:
24.5		 5eroB-2o1oA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ASP A 356
ASP A 509
ARG A 315
ASP A 496
ASP A 497
 MN  A 602 (-2.5A)
MN  A 601 ( 3.6A)
FPG  A 600 (-3.1A)
MN  A 603 ( 2.9A)
None
 1.30A 5eroB-2ongA:
11.3		 5eroB-2ongA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		9 ASP A  64
ASP A  68
ARG A  73
LYS A 151
GLN A 185
ASP A 188
ASP A 189
LYS A 202
LYS A 212
 GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
None
GRG  A 500 ( 2.6A)
GRG  A 500 (-2.8A)
 0.80A 5eroB-2q80A:
34.4		 5eroB-2q80A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 ASP A  68
ARG A  73
GLN A 185
ASP A 189
LYS A 202
 MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 (-3.2A)
None
GRG  A 500 ( 2.6A)
 1.27A 5eroB-2q80A:
34.4		 5eroB-2q80A:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 ASP B  84
ASP B  88
ARG B  93
LYS B 170
ASP B 230
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
MG  B 328 ( 3.6A)
 1.49A 5eroB-3aqcB:
27.2		 5eroB-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9r THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		5 ASP A 215
ASP A 210
ARG A 142
ASP A  71
ASP A  43
 None
MG  A 312 ( 2.3A)
MG  A 310 (-4.9A)
MG  A 309 (-2.4A)
MG  A 309 (-2.5A)
 1.49A 5eroB-3c9rA:
undetectable		 5eroB-3c9rA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		7 ASP A  92
ASP A  98
ARG A 103
LYS A 186
GLN A 225
ASP A 228
ASP A 229
 MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.1A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
None
 0.76A 5eroB-3q1oA:
24.5		 5eroB-3q1oA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 ASP A  92
ASP A  98
LYS A 186
GLN A 225
ASP A 228
 MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.1A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
 1.50A 5eroB-3q1oA:
24.5		 5eroB-3q1oA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		6 ARG A 117
LYS A 215
GLN A 254
ASP A 258
LYS A 271
LYS A 281
 DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
None
DMA  A 384 ( 2.8A)
DMA  A 384 (-2.4A)
 0.85A 5eroB-3qqvA:
28.0		 5eroB-3qqvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		7 ASP A 108
ASP A 112
ARG A 117
LYS A 215
GLN A 254
LYS A 271
LYS A 281
 MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
DMA  A 384 ( 2.8A)
DMA  A 384 (-2.4A)
 0.90A 5eroB-3qqvA:
28.0		 5eroB-3qqvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 ARG A  93
LYS A 170
GLN A 208
ASP A 211
ASP A 212
 IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
None
 1.15A 5eroB-3wjoA:
25.0		 5eroB-3wjoA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		6 ASP A  98
ARG A 107
LYS A 207
GLN A 247
ASP A 251
LYS A 264
 MG  A 403 (-2.5A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
None
0MW  A 404 ( 3.0A)
 1.22A 5eroB-4e1eA:
26.8		 5eroB-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		7 ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
ASP A 251
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
None
 0.58A 5eroB-4e1eA:
26.8		 5eroB-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		5 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 1.48A 5eroB-4e1eA:
26.8		 5eroB-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ASP A  90
ARG A  95
LYS A 162
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.26A 5eroB-4fp4A:
19.9		 5eroB-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		7 ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
ASP A 251
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
None
 0.78A 5eroB-4jzxA:
26.6		 5eroB-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		5 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 1.44A 5eroB-4jzxA:
26.6		 5eroB-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 ARG A  89
LYS A 172
GLN A 210
ASP A 213
ASP A 214
 IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 1.16A 5eroB-4lfeA:
24.0		 5eroB-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ASP A  80
ASP A  86
ARG A  91
LYS A 178
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
 0.73A 5eroB-4llsA:
24.3		 5eroB-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.89A 5eroB-4llsA:
24.3		 5eroB-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 ASP A 103
ARG A 112
LYS A 200
ASP A 244
LYS A 257
 MG  A 405 (-2.5A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
None
1WO  A 402 ( 2.8A)
 1.30A 5eroB-4p0vA:
27.1		 5eroB-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		7 ASP A 103
ASP A 107
ARG A 112
LYS A 200
GLN A 240
ASP A 243
ASP A 244
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
None
 0.53A 5eroB-4p0vA:
27.1		 5eroB-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 ASP A 103
ASP A 107
LYS A 200
GLN A 240
ASP A 243
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
 1.42A 5eroB-4p0vA:
27.1		 5eroB-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 ASP A 107
ARG A 112
GLN A 240
ASP A 243
ASP A 244
 MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
None
 1.34A 5eroB-4p0vA:
27.1		 5eroB-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		8 ASP A 103
ASP A 107
ARG A 112
LYS A 212
GLN A 252
ASP A 255
ASP A 256
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
None
3YQ  A3001 (-3.1A)
 0.80A 5eroB-4rxeA:
27.0		 5eroB-4rxeA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		5 ASP A 107
GLN A 252
ASP A 255
ASP A 256
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
None
3YQ  A3001 (-3.1A)
 1.27A 5eroB-4rxeA:
27.0		 5eroB-4rxeA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 ASP B 103
ARG B 112
LYS B 212
GLN B 252
ASP B 256
LYS B 269
 MG  B1370 (-2.5A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
None
G76  B1368 (-3.1A)
 1.17A 5eroB-5ahuB:
23.5		 5eroB-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		7 ASP B 103
ASP B 107
ARG B 112
LYS B 212
GLN B 252
ASP B 255
ASP B 256
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
None
 0.48A 5eroB-5ahuB:
23.5		 5eroB-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		5 ASP B 107
ARG B 112
GLN B 252
ASP B 255
ASP B 256
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
None
 1.27A 5eroB-5ahuB:
23.5		 5eroB-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		5 ASP A 126
ARG A 135
LYS A 243
ASP A 288
LYS A 301
 04M  A 401 ( 4.0A)
04M  A 401 (-3.5A)
04M  A 401 (-4.5A)
None
04M  A 401 ( 3.9A)
 1.48A 5eroB-5hn7A:
27.4		 5eroB-5hn7A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		7 ASP A 126
ASP A 130
ARG A 135
LYS A 243
GLN A 284
ASP A 287
ASP A 288
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-4.5A)
None
None
None
 0.81A 5eroB-5hn7A:
27.4		 5eroB-5hn7A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 ARG A 156
LYS A 244
GLN A 284
ASP A 288
LYS A 301
 C6M  A 401 (-2.7A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.7A)
None
C6M  A 401 (-2.9A)
 1.25A 5eroB-6b07A:
26.9		 5eroB-6b07A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 7 ASP A 147
ASP A 151
ARG A 156
LYS A 244
GLN A 284
ASP A 287
ASP A 288
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
None
 0.58A 5eroB-6b07A:
26.9		 5eroB-6b07A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 ASP A 147
ASP A 151
LYS A 244
GLN A 284
ASP A 287
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
 1.49A 5eroB-6b07A:
26.9		 5eroB-6b07A:
11.69