SIMILAR PATTERNS OF AMINO ACIDS FOR 5ERO_A_210A804_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		7 LEU A 102
ASP A 105
ASP A 111
ARG A 116
LYS A 202
GLN A 241
ASP A 244
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
 0.62A 5eroA-1rqjA:
26.2		 5eroA-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 209
 None
 1.10A 5eroA-1wmwA:
28.6		 5eroA-1wmwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 ASP A  85
ARG A  90
LYS A 160
GLN A 197
ASP A 200
 None
 1.36A 5eroA-2azkA:
22.0		 5eroA-2azkA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 LEU A  78
ASP A  85
ARG A  90
GLN A 197
ASP A 200
 None
 0.83A 5eroA-2azkA:
22.0		 5eroA-2azkA:
27.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		8 LEU A  77
ASP A  80
ASP A  84
ARG A  89
LYS A 174
GLN A 211
ASP A 214
LYS A 238
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
MG  A 341 ( 4.6A)
 0.58A 5eroA-2dh4A:
32.5		 5eroA-2dh4A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		6 LEU A 112
ASP A 115
ASP A 119
ARG A 124
LYS A 210
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.66A 5eroA-2o1oA:
24.7		 5eroA-2o1oA:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		9 LEU A  61
ASP A  64
ASP A  68
ARG A  73
LYS A 151
GLN A 185
ASP A 188
LYS A 202
LYS A 212
 None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
GRG  A 500 ( 2.6A)
GRG  A 500 (-2.8A)
 0.72A 5eroA-2q80A:
35.2		 5eroA-2q80A:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.74A 5eroA-3aq0A:
25.6		 5eroA-3aq0A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 1.10A 5eroA-3aqcB:
27.4		 5eroA-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
 0.66A 5eroA-3p41A:
21.8		 5eroA-3p41A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		7 LEU A  89
ASP A  92
ASP A  98
ARG A 103
LYS A 186
GLN A 225
ASP A 228
 DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.1A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
 0.69A 5eroA-3q1oA:
24.3		 5eroA-3q1oA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		8 LEU A 105
ASP A 108
ASP A 112
ARG A 117
LYS A 215
GLN A 254
LYS A 271
LYS A 281
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
DMA  A 384 ( 2.8A)
DMA  A 384 (-2.4A)
 0.88A 5eroA-3qqvA:
28.3		 5eroA-3qqvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
 0.69A 5eroA-3zouA:
21.5		 5eroA-3zouA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		7 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 0.61A 5eroA-4e1eA:
27.0		 5eroA-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		5 LEU A  95
ASP A  98
LYS A 207
GLN A 247
LYS A 264
 None
MG  A 403 (-2.5A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
0MW  A 404 ( 3.0A)
 1.32A 5eroA-4e1eA:
27.0		 5eroA-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
GLN A 199
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.19A 5eroA-4fp4A:
19.9		 5eroA-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.77A 5eroA-4gp1A:
24.4		 5eroA-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		7 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.74A 5eroA-4jzxA:
26.9		 5eroA-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 LEU A  75
ARG A  89
LYS A 172
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.93A 5eroA-4lfeA:
24.4		 5eroA-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 LEU A  75
ASP A  78
ASP A  84
ARG A  89
LYS A 172
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
 0.76A 5eroA-4lfeA:
24.4		 5eroA-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A  77
ARG A  91
LYS A 178
GLN A 213
LYS A 230
 None
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
GST  A 302 (-2.7A)
 1.46A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		6 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
ASP A 216
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
 0.72A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		6 LEU A  77
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.84A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 LEU A 100
ASP A 103
ARG A 112
LYS A 200
LYS A 257
 None
MG  A 405 (-2.5A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
1WO  A 402 ( 2.8A)
 1.36A 5eroA-4p0vA:
27.5		 5eroA-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		7 LEU A 100
ASP A 103
ASP A 107
ARG A 112
LYS A 200
GLN A 240
ASP A 243
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
 0.62A 5eroA-4p0vA:
27.5		 5eroA-4p0vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		8 LEU A 100
ASP A 103
ASP A 107
ARG A 112
LYS A 212
GLN A 252
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.86A 5eroA-4rxeA:
27.3		 5eroA-4rxeA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		5 LEU A  71
ASP A  80
ARG A  85
GLN A 198
ASP A 201
 None
 0.83A 5eroA-4wk5A:
23.7		 5eroA-4wk5A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 LEU B 100
ASP B 103
ARG B 112
LYS B 212
GLN B 252
LYS B 269
 None
MG  B1370 (-2.5A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
G76  B1368 (-3.1A)
 1.22A 5eroA-5ahuB:
24.1		 5eroA-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		7 LEU B 100
ASP B 103
ASP B 107
ARG B 112
LYS B 212
GLN B 252
ASP B 255
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
 0.55A 5eroA-5ahuB:
24.1		 5eroA-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		6 ASP A 126
ASP A 130
ARG A 135
LYS A 243
GLN A 284
ASP A 287
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-4.5A)
None
None
 0.76A 5eroA-5hn7A:
27.3		 5eroA-5hn7A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 6 ASP A 147
ASP A 151
ARG A 156
LYS A 244
GLN A 284
ASP A 287
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
 0.53A 5eroA-6b07A:
27.4		 5eroA-6b07A:
11.69