SIMILAR PATTERNS OF AMINO ACIDS FOR 5ERM_B_210B704

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1n21	(+)-BORNYL DIPHOSPHATE SYNTHASE (Salvia officinalis)	PF01397 (Terpene_synth) PF03936 (Terpene_synth_C)	5	ASP A 351 ARG A 493 VAL A 452 GLU A 504 ARG A 314	MG  A 703 (-2.4A) 3AG  A 900 (-2.5A) 3AG  A 900 ( 4.8A) MG  A 702 ( 2.6A) 3AG  A 900 (-3.0A)	1.11A	5ermB-1n21A: 12.7	5ermB-1n21A: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1yyr	TRICHODIENE SYNTHASE (Fusarium sporotrichioides)	PF06330 (TRI5)	5	ASN A 225 SER A 229 LYS A 232 GLU A 233 ARG A 304	SAZ  A 709 (-3.3A) None None None SAZ  A 709 ( 4.5A)	0.72A	5ermB-1yyrA: 6.1	5ermB-1yyrA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lg5	EPI-ISOZIZAENE SYNTHASE (Streptomyces coelicolor)	no annotation	8	ASP A  99 ARG A 194 ASN A 240 SER A 244 LYS A 247 GLU A 248 ARG A 338 TYR A 339	MG  A 701 (-2.5A) POP  A 703 (-2.8A) MG  A 702 (-2.6A) MG  A 702 ( 2.3A) POP  A 703 (-2.8A) MG  A 702 ( 2.6A) POP  A 703 (-4.0A) POP  A 703 ( 4.4A)	0.56A	5ermB-3lg5A: 23.1	5ermB-3lg5A: 26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3p5p	TAXADIENE SYNTHASE (Taxus brevifolia)	PF01397 (Terpene_synth) PF03936 (Terpene_synth_C)	5	ASP A 613 ARG A 754 VAL A 714 ASN A 757 GLU A 765	A3C  A 911 ( 3.8A) A3C  A 911 (-3.4A) A3C  A 911 (-4.8A) MG  A 901 ( 2.7A) MG  A 901 ( 2.6A)	0.81A	5ermB-3p5pA: 16.4	5ermB-3p5pA: 18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3v1v	2-METHYLISOBORNEOL SYNTHASE (Streptomyces coelicolor)	no annotation	6	ARG A 300 ASN A 345 SER A 349 GLU A 353 ARG A 433 TYR A 434	GST  A 511 (-3.4A) MG  A 501 ( 2.7A) MG  A 501 ( 2.3A) MG  A 501 ( 2.6A) GST  A 511 (-3.9A) GST  A 511 (-4.6A)	0.66A	5ermB-3v1vA: 10.5	5ermB-3v1vA: 24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3v1v	2-METHYLISOBORNEOL SYNTHASE (Streptomyces coelicolor)	no annotation	6	ASN A 345 SER A 349 LYS A 352 GLU A 353 ARG A 433 TYR A 434	MG  A 501 ( 2.7A) MG  A 501 ( 2.3A) GST  A 511 (-3.1A) MG  A 501 ( 2.6A) GST  A 511 (-3.9A) GST  A 511 (-4.6A)	0.65A	5ermB-3v1vA: 10.5	5ermB-3v1vA: 24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4okm	TERPENE SYNTHASE METAL-BINDING DOMAIN-CONTAINING PROTEIN (Streptomyces pristinaespiralis)	no annotation	7	ARG A 178 ASN A 224 SER A 228 LYS A 231 GLU A 232 ARG A 310 TYR A 311	PPV  A 904 (-2.9A) MG  A 903 ( 2.7A) MG  A 903 ( 2.3A) PPV  A 904 (-2.8A) MG  A 903 ( 2.7A) PPV  A 904 (-3.9A) PPV  A 904 (-4.4A)	0.52A	5ermB-4okmA: 24.5	5ermB-4okmA: 22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4okm	TERPENE SYNTHASE METAL-BINDING DOMAIN-CONTAINING PROTEIN (Streptomyces pristinaespiralis)	no annotation	5	ASP A  82 ARG A 178 ASN A 224 SER A 228 ARG A 310	MG  A 902 ( 2.5A) PPV  A 904 (-2.9A) MG  A 903 ( 2.7A) MG  A 903 ( 2.3A) PPV  A 904 (-3.9A)	0.82A	5ermB-4okmA: 24.5	5ermB-4okmA: 22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4zq8	ISOPRENOID SYNTHASE (Streptomyces lydicus)	no annotation	5	ASN A 259 SER A 263 GLU A 267 ARG A 345 TYR A 346	None	0.93A	5ermB-4zq8A: 10.4	5ermB-4zq8A: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5a0k	LABDANE-RELATED DITERPENE SYNTHASE (Streptomyces sp.)	no annotation	6	ARG A 184 VAL A 188 ASN A 230 SER A 234 ARG A 316 TYR A 317	MG  A1323 (-4.0A) None MG  A1323 (-3.5A) MG  A1323 (-3.4A) None None	0.67A	5ermB-5a0kA: 11.2	5ermB-5a0kA: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dz2	GERMACRADIENOL/GEOSM IN SYNTHASE (Streptomyces coelicolor)	no annotation	7	ASP A  86 ARG A 184 ASN A 229 SER A 233 GLU A 237 ARG A 325 TYR A 326	MG  A 401 (-2.5A) 212  A 404 (-3.6A) MG  A 402 ( 2.6A) MG  A 402 ( 2.5A) MG  A 402 ( 2.7A) 212  A 404 (-4.0A) 212  A 404 (-4.3A)	0.66A	5ermB-5dz2A: 10.9	5ermB-5dz2A: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5in8	ARISTOLOCHENE SYNTHASE (Aspergillus terreus)	no annotation	7	ARG A 169 ASN A 213 SER A 217 LYS A 220 GLU A 221 ARG A 308 TYR A 309	MG  A 403 ( 4.2A) MG  A 403 ( 2.8A) MG  A 403 ( 2.4A) PO4  A 404 (-2.8A) MG  A 403 ( 2.8A) PO4  A 404 (-3.9A) PO4  A 404 (-4.4A)	0.53A	5ermB-5in8A: 4.3	5ermB-5in8A: 27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5in8	ARISTOLOCHENE SYNTHASE (Aspergillus terreus)	no annotation	7	ARG A 169 VAL A 173 ASN A 213 SER A 217 GLU A 221 ARG A 308 TYR A 309	MG  A 403 ( 4.2A) None MG  A 403 ( 2.8A) MG  A 403 ( 2.4A) MG  A 403 ( 2.8A) PO4  A 404 (-3.9A) PO4  A 404 (-4.4A)	0.60A	5ermB-5in8A: 4.3	5ermB-5in8A: 27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	no annotation	8	ASP A  81 ARG A 174 ASN A 220 SER A 224 LYS A 227 GLU A 228 ARG A 314 TYR A 315	MG  A 404 (-2.6A) 0FV  A 400 ( 3.0A) 0FV  A 400 (-2.7A) MG  A 402 (-2.2A) 0FV  A 400 ( 2.5A) MG  A 402 (-2.6A) LA6  A 401 ( 3.8A) 0FV  A 400 ( 4.4A)	0.47A	5ermB-5nx7A: 9.1	5ermB-5nx7A: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5veo	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 5 (Mus musculus)	PF01663 (Phosphodiest)	5	ASP A 200 VAL A 197 LYS A  45 ARG A  39 TYR A  42	None	1.39A	5ermB-5veoA: undetectable	5ermB-5veoA: 21.93