SIMILAR PATTERNS OF AMINO ACIDS FOR 5EQB_A_1YNA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 TYR A 243
TYR A 191
PRO A  68
THR A  61
 None
GLU  A 500 (-4.1A)
None
None
 1.22A 5eqbA-3ihaA:
0.0		 5eqbA-3ihaA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 TYR A  64
TYR A 118
PRO A 230
THR A 311
 None
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.2A)
HEM  A 580 (-3.6A)
 0.42A 5eqbA-5fsaA:
57.0		 5eqbA-5fsaA:
59.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftw CHEMOTAXIS PROTEIN
METHYLTRANSFERASE

(Bacillus
subtilis) 		PF01739
(CheR)
PF03705
(CheR_N) 		4 TYR A  72
TYR A 124
PRO A 108
THR A 173
 None
None
None
SO4  A1260 (-3.7A)
 1.45A 5eqbA-5ftwA:
0.0		 5eqbA-5ftwA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 TYR A  72
TYR A 126
PRO A 238
THR A 318
 None
VOR  A 602 ( 3.8A)
None
HEM  A 601 (-3.4A)
 0.36A 5eqbA-5hs1A:
63.2		 5eqbA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 TYR A  73
TYR A 127
PRO A 239
THR A 319
 1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.8A)
HEM  A 601 ( 3.5A)
 0.28A 5eqbA-5jlcA:
59.7		 5eqbA-5jlcA:
84.08