SIMILAR PATTERNS OF AMINO ACIDS FOR 5EQB_A_1YNA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		5 GLY A 187
ILE A 372
GLY A 374
GLY A 398
LEU A 410
 None
None
None
ADP  A 421 ( 4.3A)
None
 1.01A 5eqbA-13pkA:
0.0		 5eqbA-13pkA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		5 GLY A 368
PHE A 167
PHE A 200
GLY A 168
GLY A 398
 None
None
None
3PG  A 423 (-4.7A)
ADP  A 421 ( 4.3A)
 1.03A 5eqbA-13pkA:
0.0		 5eqbA-13pkA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLY A 182
ILE A 256
GLY A 252
GLY A 173
THR A 164
 None
 1.04A 5eqbA-1b0kA:
0.0		 5eqbA-1b0kA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02783
(MCR_beta_N) 		5 GLY A 475
ILE B 375
GLY B 371
GLY B 369
MET A 483
 None
None
None
TP7  A1554 ( 3.9A)
None
 1.03A 5eqbA-1e6vA:
0.0		 5eqbA-1e6vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanothermobacter
thermautotrophicus) 		PF00296
(Bac_luciferase) 		5 GLY A 127
GLY A  95
GLY A  93
LEU A  90
THR A 123
 None
 1.00A 5eqbA-1f07A:
0.0		 5eqbA-1f07A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		5 GLY A  61
PHE A  36
GLY A  41
GLY A  87
LEU A  17
 None
 0.97A 5eqbA-1fy2A:
0.0		 5eqbA-1fy2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 GLY A   8
GLY A  11
LEU A  40
PHE A 107
THR A  75
 MAN  A 407 ( 4.8A)
MAN  A 414 ( 4.7A)
None
None
None
 1.08A 5eqbA-1ia5A:
0.0		 5eqbA-1ia5A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		5 GLY A 268
TYR A 535
GLY A 556
GLY A 408
PHE A 527
 None
 1.11A 5eqbA-1iduA:
0.0		 5eqbA-1iduA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		5 GLY A 208
TYR A  44
GLY A  30
GLY A   7
THR A 134
 None
 0.79A 5eqbA-1jaxA:
0.0		 5eqbA-1jaxA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		5 GLY A  46
ILE A  35
GLY A  92
LEU A  98
PHE A  79
 None
 1.11A 5eqbA-1phzA:
undetectable		 5eqbA-1phzA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		5 GLY A  99
PHE A  88
GLY A  82
GLY A 110
THR A 101
 None
 1.06A 5eqbA-1t1eA:
undetectable		 5eqbA-1t1eA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 GLY A1030
TYR A 841
GLY A 822
GLY A 818
HIS A1032
 None
None
None
None
FAD  A1452 (-3.5A)
 1.08A 5eqbA-1tllA:
undetectable		 5eqbA-1tllA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 GLY A 128
GLY A 126
LEU A 444
PHE A 442
THR A 455
 EDO  A1902 (-3.4A)
EDO  A1902 ( 4.3A)
None
None
None
 0.82A 5eqbA-1ukcA:
undetectable		 5eqbA-1ukcA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 GLY B 216
ILE B 125
GLY B 280
HIS B 375
THR B 214
 None
 1.11A 5eqbA-1wytB:
2.1		 5eqbA-1wytB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		6 GLY A 300
PHE A  29
GLY A 242
GLY A 244
LEU A 275
HIS A 330
 None
None
EDO  A 404 ( 4.5A)
None
None
ZN  A 400 (-3.2A)
 1.38A 5eqbA-2ashA:
undetectable		 5eqbA-2ashA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96) 		PF00082
(Peptidase_S8) 		5 GLY A  79
ILE A  60
GLY A 102
GLY A 100
THR A  76
 None
 1.02A 5eqbA-2b6nA:
undetectable		 5eqbA-2b6nA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE

(Chlorobaculum
tepidum) 		PF00106
(adh_short) 		5 ILE A  49
GLY A  11
GLY A   9
LEU A   6
THR A  78
 None
NAP  A 800 (-3.9A)
NAP  A 800 (-3.2A)
None
None
 1.03A 5eqbA-2bd0A:
undetectable		 5eqbA-2bd0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521

(Archaeoglobus
fulgidus) 		PF01661
(Macro) 		5 GLY A  71
ILE A 144
TYR A 145
GLY A  42
GLY A  40
 None
ADP  A1193 (-3.7A)
ADP  A1193 (-3.4A)
ADP  A1193 (-3.1A)
None
 1.10A 5eqbA-2bfrA:
undetectable		 5eqbA-2bfrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG

(Thermus
thermophilus) 		PF01887
(SAM_adeno_trans) 		5 GLY A  62
ILE A 188
GLY A 226
GLY A 229
LEU A 102
 None
 1.03A 5eqbA-2cw5A:
undetectable		 5eqbA-2cw5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eix NADH-CYTOCHROME B5
REDUCTASE

(Physarum
polycephalum) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 GLY A 272
ILE A 166
GLY A 163
GLY A 256
MET A 264
 None
 1.04A 5eqbA-2eixA:
undetectable		 5eqbA-2eixA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A 158
GLY A  76
GLY A  78
HIS A 203
THR A 155
 None
 1.07A 5eqbA-2eklA:
undetectable		 5eqbA-2eklA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		5 GLY A 217
PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.89A 5eqbA-2jfwA:
undetectable		 5eqbA-2jfwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		5 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 1.05A 5eqbA-2ow4A:
undetectable		 5eqbA-2ow4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		6 GLY A 358
PHE A  28
ILE A   4
TYR A  19
PHE A 231
GLY A   3
 None
 1.40A 5eqbA-2p0oA:
undetectable		 5eqbA-2p0oA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		5 GLY A 242
GLY A  84
GLY A  86
LEU A 238
THR A 168
 None
 1.08A 5eqbA-2p17A:
undetectable		 5eqbA-2p17A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 185
GLY A 186
GLY A 181
LEU A 151
THR A 243
 FAD  A 480 (-4.3A)
None
None
None
None
 1.11A 5eqbA-2qaeA:
undetectable		 5eqbA-2qaeA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rc5 FERREDOXIN-NADP
REDUCTASE

(Leptospira
interrogans) 		PF00175
(NAD_binding_1) 		5 PHE A 164
ILE A 168
GLY A 166
GLY A 266
HIS A 301
 None
 1.09A 5eqbA-2rc5A:
undetectable		 5eqbA-2rc5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 GLY A 346
ILE A 165
GLY A 163
LEU A 217
THR A 264
 None
 0.94A 5eqbA-2uvfA:
undetectable		 5eqbA-2uvfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		6 GLY A 119
PHE A 237
ILE A 235
PHE A 153
GLY A 236
PHE A  79
 None
 1.28A 5eqbA-2wzsA:
undetectable		 5eqbA-2wzsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A  22
PHE A 149
GLY A 100
GLY A 104
PHE A 238
 None
 1.02A 5eqbA-2x40A:
undetectable		 5eqbA-2x40A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		6 GLY A 375
ILE A 232
TYR A 233
GLY A  16
GLY A  18
HIS A 305
 None
 1.21A 5eqbA-3e1hA:
undetectable		 5eqbA-3e1hA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		5 GLY A 356
ILE A  13
GLY A  14
GLY A  19
PHE A 293
 None
FAD  A 600 (-4.9A)
FAD  A 600 (-3.2A)
None
None
 1.03A 5eqbA-3e1tA:
undetectable		 5eqbA-3e1tA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		6 GLY A 375
ILE A 232
TYR A 233
GLY A  16
GLY A  18
HIS A 305
 None
 1.15A 5eqbA-3euoA:
undetectable		 5eqbA-3euoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 GLY A 421
TYR A 363
PHE A 351
GLY A 338
GLY A 336
 None
 0.99A 5eqbA-3gwjA:
undetectable		 5eqbA-3gwjA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT

(Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ILE C  30
GLY C  32
GLY C 113
LEU C 163
THR C 143
 FAD  C 900 ( 4.7A)
FAD  C 900 (-3.4A)
FAD  C 900 (-3.3A)
FAD  C 900 ( 4.7A)
None
 1.09A 5eqbA-3hrdC:
undetectable		 5eqbA-3hrdC:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		5 GLY A  14
PHE A  79
ILE A  81
GLY A 221
GLY A 235
 FAD  A 536 (-3.3A)
VAK  A 537 (-4.7A)
None
None
None
 0.79A 5eqbA-3ihgA:
undetectable		 5eqbA-3ihgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		5 GLY A  16
PHE A  79
ILE A  81
GLY A 221
GLY A 235
 FAD  A 536 (-3.9A)
VAK  A 537 (-4.7A)
None
None
None
 0.93A 5eqbA-3ihgA:
undetectable		 5eqbA-3ihgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 GLY A 116
ILE A 166
GLY A 136
GLY A 142
PHE A 131
 None
None
GDP  A 900 (-3.6A)
None
None
 1.12A 5eqbA-3j4sA:
undetectable		 5eqbA-3j4sA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1

(Homo sapiens) 		PF14429
(DOCK-C2) 		5 GLY A 459
PHE A 437
PHE A 513
GLY A 435
HIS A 508
 None
 1.09A 5eqbA-3l4cA:
undetectable		 5eqbA-3l4cA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE

(Desulfococcus
multivorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A  64
GLY A 127
GLY A 125
LEU A 117
THR A  54
 None
FAD  A 400 ( 4.4A)
None
None
None
 1.08A 5eqbA-3mpiA:
undetectable		 5eqbA-3mpiA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		5 GLY A  73
GLY A 129
LEU A  39
HIS A  40
PHE A  91
 None
 1.13A 5eqbA-3nwoA:
undetectable		 5eqbA-3nwoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 151
ILE A 164
GLY A 347
GLY A 350
THR A 135
 None
 1.01A 5eqbA-3q9tA:
0.0		 5eqbA-3q9tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 379
ILE A 298
PHE A 339
GLY A 295
PHE A 424
 None
 1.07A 5eqbA-3qdkA:
undetectable		 5eqbA-3qdkA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkc GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Antirrhinum
majus) 		no annotation 5 GLY B 217
GLY B 245
LEU B  52
HIS B 184
THR B 214
 None
 1.11A 5eqbA-3qkcB:
undetectable		 5eqbA-3qkcB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qum PROSTATE-SPECIFIC
ANTIGEN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY P 133
ILE P 144
GLY P 142
GLY P 140
THR P 135
 None
 0.96A 5eqbA-3qumP:
undetectable		 5eqbA-3qumP:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq1 AMINOTRANSFERASE
CLASS I AND II

(Veillonella
parvula) 		PF00155
(Aminotran_1_2) 		5 GLY A  40
ILE A 112
TYR A 136
GLY A 110
GLY A 107
 None
 1.08A 5eqbA-3rq1A:
2.0		 5eqbA-3rq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 GLY A  83
TYR A 167
GLY A 215
GLY A 217
PHE A 248
 None
 1.11A 5eqbA-3syjA:
undetectable		 5eqbA-3syjA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 GLY A1334
GLY A1505
GLY A1416
LEU A1316
PHE A1385
 None
 1.13A 5eqbA-3topA:
undetectable		 5eqbA-3topA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 GLY A   7
PHE A 349
GLY A 390
THR A  83
MET A 156
 None
 1.07A 5eqbA-3u95A:
undetectable		 5eqbA-3u95A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 5 GLY B 177
ILE B 386
GLY B 361
GLY B 341
LEU B 116
 None
 1.11A 5eqbA-3w0lB:
undetectable		 5eqbA-3w0lB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A  80
TYR A 155
GLY A 236
GLY A 184
HIS A 215
 None
 0.87A 5eqbA-4cakA:
undetectable		 5eqbA-4cakA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLY A 157
ILE A  12
GLY A  14
GLY A  17
THR A 154
 None
None
PO4  A 401 ( 4.8A)
PO4  A 402 (-3.1A)
PO4  A 403 (-3.7A)
 1.06A 5eqbA-4dpkA:
undetectable		 5eqbA-4dpkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLY A 194
ILE A 334
GLY A 305
GLY A 307
LEU A 155
 None
 0.85A 5eqbA-4egeA:
undetectable		 5eqbA-4egeA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 100
PHE A  63
GLY A 120
GLY A 114
LEU A  89
 None
 1.01A 5eqbA-4jbhA:
undetectable		 5eqbA-4jbhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo8 KILLER CELL
LECTIN-LIKE RECEPTOR
8
M157

(Murid
betaherpesvirus
1;
Mus musculus) 		PF08391
(Ly49)
PF11624
(M157) 		5 ILE B 116
GLY A 172
GLY A 170
LEU A 109
THR A  53
 None
 1.08A 5eqbA-4jo8B:
undetectable		 5eqbA-4jo8B:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		5 PHE A 388
GLY A 344
GLY A 450
LEU A 404
THR A 414
 None
 1.05A 5eqbA-4oe5A:
undetectable		 5eqbA-4oe5A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 GLY A 679
PHE A 546
PHE A 466
GLY A 545
PHE A 707
 None
 1.04A 5eqbA-4oonA:
undetectable		 5eqbA-4oonA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		5 ILE A 212
TYR A 213
GLY A 125
GLY A 543
LEU A 514
 None
 0.98A 5eqbA-4r3uA:
undetectable		 5eqbA-4r3uA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		5 ILE A 101
TYR A 283
GLY A 102
GLY A 257
LEU A 275
 None
None
PMP  A 409 (-3.6A)
None
None
 1.11A 5eqbA-4rkcA:
2.5		 5eqbA-4rkcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvo PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
thetaiotaomicron) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 GLY A 316
ILE A 282
GLY A 283
HIS A 258
THR A 318
 None
None
None
ZN  A 501 (-3.2A)
None
 0.95A 5eqbA-4rvoA:
undetectable		 5eqbA-4rvoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Yersinia
enterocolitica) 		PF01380
(SIS) 		5 TYR A 146
GLY A  74
LEU A 127
PHE A 153
THR A 132
 None
 1.12A 5eqbA-4s12A:
undetectable		 5eqbA-4s12A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  98
PHE A  61
ILE A 121
GLY A 116
GLY A 110
 None
 1.00A 5eqbA-4uekA:
undetectable		 5eqbA-4uekA:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		5 GLY A  69
PHE A 130
TYR A 136
PHE A 229
HIS A 374
 None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
 0.97A 5eqbA-4uymA:
52.5		 5eqbA-4uymA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgj BEPC PROTEIN

(Bartonella
tribocorum) 		PF02661
(Fic) 		5 GLY A 168
GLY A 151
GLY A 153
PHE A  50
THR A 170
 None
ANP  A 301 (-3.1A)
ANP  A 301 (-3.3A)
None
None
 1.07A 5eqbA-4wgjA:
undetectable		 5eqbA-4wgjA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A 250
ILE A 197
GLY A 215
GLY A 258
LEU A 360
 None
 1.07A 5eqbA-4wkyA:
undetectable		 5eqbA-4wkyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmo XEEL PROTEIN

(Xenopus laevis) 		no annotation 5 GLY F 107
TYR F 216
PHE F 204
GLY F 233
LEU F 178
 None
 1.03A 5eqbA-4wmoF:
undetectable		 5eqbA-4wmoF:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbl PHOTOSESITIZER
MKILLERORANGE

(Hydrozoa) 		PF01353
(GFP) 		5 PHE A 165
ILE A 142
PHE A  98
GLY A 164
MET A 104
 None
 1.11A 5eqbA-4zblA:
undetectable		 5eqbA-4zblA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 465
ILE A 437
GLY A 553
LEU A 414
THR A 456
 None
 1.04A 5eqbA-5a7mA:
undetectable		 5eqbA-5a7mA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awn HEAVY CHAIN OF
3BC176 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  85
ILE H  34
GLY H 104
PHE H  63
THR H  87
 None
 1.12A 5eqbA-5awnH:
undetectable		 5eqbA-5awnH:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 161
GLY A  93
GLY A 363
PHE A 328
THR A 150
 None
 1.06A 5eqbA-5bz4A:
undetectable		 5eqbA-5bz4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		5 GLY A 380
PHE A  70
PHE A  24
GLY A 128
GLY A 132
 None
 0.92A 5eqbA-5c65A:
undetectable		 5eqbA-5c65A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 GLY A 401
GLY A 305
GLY A 301
LEU A 290
THR A 404
 None
 1.05A 5eqbA-5dotA:
undetectable		 5eqbA-5dotA:
16.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 GLY A  65
GLY A 308
LEU A 376
HIS A 377
MET A 508
 X2N  A 590 ( 4.0A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.02A 5eqbA-5fsaA:
57.0		 5eqbA-5fsaA:
59.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		11 GLY A  65
PHE A 126
ILE A 131
TYR A 132
PHE A 228
GLY A 303
GLY A 307
LEU A 376
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-3.5A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.59A 5eqbA-5fsaA:
57.0		 5eqbA-5fsaA:
59.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		5 GLY A 977
PHE A 483
PHE A 497
GLY A 486
GLY A 954
 None
 1.09A 5eqbA-5fswA:
undetectable		 5eqbA-5fswA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv1 ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		5 GLY A 214
PHE A 150
GLY A 248
GLY A 250
PHE A 241
 None
 1.11A 5eqbA-5gv1A:
undetectable		 5eqbA-5gv1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyg ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		5 GLY A 214
PHE A 150
GLY A 248
GLY A 250
PHE A 241
 None
 1.06A 5eqbA-5gygA:
undetectable		 5eqbA-5gygA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 GLY A  73
GLY A 315
LEU A 380
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
VOR  A 602 (-4.0A)
None
None
 0.47A 5eqbA-5hs1A:
63.2		 5eqbA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 GLY A  73
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 310
GLY A 314
LEU A 380
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-4.3A)
VOR  A 602 (-3.0A)
VOR  A 602 (-4.0A)
None
None
None
 0.55A 5eqbA-5hs1A:
63.2		 5eqbA-5hs1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzl LMO2445 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 GLY B  35
ILE B 113
GLY B  91
GLY B  66
LEU B  72
 CA  B 407 (-4.1A)
None
None
None
None
 1.07A 5eqbA-5hzlB:
undetectable		 5eqbA-5hzlB:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		6 GLY A  74
GLY A 316
LEU A 381
HIS A 382
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
HEM  A 601 (-3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.83A 5eqbA-5jlcA:
59.7		 5eqbA-5jlcA:
84.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		12 GLY A  74
PHE A 135
ILE A 140
TYR A 141
PHE A 237
GLY A 311
GLY A 315
LEU A 381
HIS A 382
PHE A 385
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 (-3.9A)
1YN  A 602 ( 3.6A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.38A 5eqbA-5jlcA:
59.7		 5eqbA-5jlcA:
84.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		5 ILE A  83
TYR A  10
GLY A 616
GLY A 614
LEU A 666
 None
 0.95A 5eqbA-5kvuA:
undetectable		 5eqbA-5kvuA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 GLY B 348
ILE A 244
GLY A 253
GLY A 255
HIS A 190
 GNP  B 401 (-3.4A)
None
None
None
GNP  B 401 (-4.4A)
 0.99A 5eqbA-5l3sB:
undetectable		 5eqbA-5l3sB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.10A 5eqbA-5m7rA:
undetectable		 5eqbA-5m7rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mn5 CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 104
ILE A 217
GLY A 259
GLY A 314
THR A 133
 GTP  A 401 (-3.4A)
None
None
None
None
 1.07A 5eqbA-5mn5A:
undetectable		 5eqbA-5mn5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		5 GLY A 580
ILE A 177
GLY A 185
GLY A 441
LEU A 497
 None
 0.98A 5eqbA-5svcA:
undetectable		 5eqbA-5svcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		5 GLY A 221
PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 1.08A 5eqbA-5uhkA:
undetectable		 5eqbA-5uhkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM

(Brucella
abortus) 		PF04069
(OpuAC) 		5 GLY A 156
ILE A 224
GLY A 219
GLY A 130
LEU A 161
 None
 1.09A 5eqbA-5uveA:
undetectable		 5eqbA-5uveA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A 509
PHE A 150
LEU A 486
PHE A 479
THR A 510
 None
 1.08A 5eqbA-5v9xA:
undetectable		 5eqbA-5v9xA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26

(Saccharomyces
cerevisiae) 		no annotation 5 GLY M 450
ILE M 319
GLY M 321
GLY M 498
THR M 447
 None
 1.12A 5eqbA-5vvrM:
undetectable		 5eqbA-5vvrM:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 GLY A 319
ILE A 106
GLY A 302
LEU A  81
PHE A  89
 None
 1.11A 5eqbA-5w19A:
undetectable		 5eqbA-5w19A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		5 GLY A 439
GLY A 114
GLY A 109
LEU A 327
THR A 440
 None
None
EPE  A 600 (-3.0A)
MLI  A 601 (-4.6A)
None
 0.97A 5eqbA-5w1uA:
undetectable		 5eqbA-5w1uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 5 GLY A  82
ILE A  60
GLY A 105
GLY A 103
THR A  79
 None
 0.99A 5eqbA-5wslA:
undetectable		 5eqbA-5wslA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 PHE A 637
ILE A 588
GLY A  80
GLY A  84
THR A 746
 None
 1.03A 5eqbA-5wugA:
undetectable		 5eqbA-5wugA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN

(Pisum sativum) 		no annotation 5 GLY B 154
ILE B 265
GLY B 173
GLY B 176
THR B 159
 None
None
None
None
LMG  B2633 (-4.2A)
 1.11A 5eqbA-5xnmB:
undetectable		 5eqbA-5xnmB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		5 GLY A1543
PHE A1247
ILE A1248
GLY A1251
THR A1545
 None
 0.96A 5eqbA-5xsyA:
0.7		 5eqbA-5xsyA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL

(Homo sapiens) 		PF00384
(Molybdopterin)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 GLY M 376
ILE M 451
GLY M 433
GLY M 404
THR M 374
 None
 0.95A 5eqbA-5xtbM:
undetectable		 5eqbA-5xtbM:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gc6 50S RIBOSOMAL
PROTEIN L2

(Escherichia
coli) 		no annotation 5 GLY C 195
ILE C  73
TYR C  95
GLY C  72
GLY C 118
 None
A  A1490 ( 4.9A)
None
None
None
 1.05A 5eqbA-6gc6C:
undetectable		 5eqbA-6gc6C:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 5 ILE A  48
GLY A 214
LEU A 271
PHE A  74
THR A 223
 None
 1.12A 5eqbA-6gh2A:
undetectable		 5eqbA-6gh2A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 TYR A 243
TYR A 191
PRO A  68
THR A  61
 None
GLU  A 500 (-4.1A)
None
None
 1.22A 5eqbA-3ihaA:
0.0		 5eqbA-3ihaA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 TYR A  64
TYR A 118
PRO A 230
THR A 311
 None
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.2A)
HEM  A 580 (-3.6A)
 0.42A 5eqbA-5fsaA:
57.0		 5eqbA-5fsaA:
59.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftw CHEMOTAXIS PROTEIN
METHYLTRANSFERASE

(Bacillus
subtilis) 		PF01739
(CheR)
PF03705
(CheR_N) 		4 TYR A  72
TYR A 124
PRO A 108
THR A 173
 None
None
None
SO4  A1260 (-3.7A)
 1.45A 5eqbA-5ftwA:
0.0		 5eqbA-5ftwA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 TYR A  72
TYR A 126
PRO A 238
THR A 318
 None
VOR  A 602 ( 3.8A)
None
HEM  A 601 (-3.4A)
 0.36A 5eqbA-5hs1A:
63.2		 5eqbA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 TYR A  73
TYR A 127
PRO A 239
THR A 319
 1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.8A)
HEM  A 601 ( 3.5A)
 0.28A 5eqbA-5jlcA:
59.7		 5eqbA-5jlcA:
84.08