SIMILAR PATTERNS OF AMINO ACIDS FOR 5ENT_C_MIYC901_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 PHE A 752
GLY A 753
SER A 754
GLU A 747
ALA A 468
 None
 1.01A 5entC-1g8kA:
undetectable		 5entC-1g8kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkg HEXOKINASE A

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 GLN A 246
PHE A 210
GLY A 211
SER A 212
ASN A 284
 None
 1.26A 5entC-1hkgA:
undetectable		 5entC-1hkgA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 SER A 824
PHE A1017
GLY A1019
GLU A1041
ALA A1002
 None
 1.24A 5entC-1jx2A:
0.0		 5entC-1jx2A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 SER A 282
SER A 259
GLU A 229
ILE A 264
ALA A 267
 None
 1.24A 5entC-1kcxA:
0.0		 5entC-1kcxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 SER A 427
GLN A 387
GLY A 241
GLU A 228
ILE A 411
 None
 1.09A 5entC-1r3nA:
5.2		 5entC-1r3nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc2 AQUAPORIN Z

(Escherichia
coli) 		no annotation 6 SER B 190
GLY B 216
SER B 142
ASN B  63
ILE B  68
ALA B  72
 None
 1.49A 5entC-1rc2B:
undetectable		 5entC-1rc2B:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybd URIDYLATE KINASE

(Neisseria
meningitidis) 		PF00696
(AA_kinase) 		5 SER A  65
GLY A  56
SER A  17
GLU A  19
ALA A 148
 None
GOL  A 250 ( 4.1A)
GOL  A 250 (-4.2A)
GOL  A 250 ( 3.7A)
None
 1.28A 5entC-1ybdA:
0.6		 5entC-1ybdA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0k FYVE-FINGER-CONTAINI
NG RAB5 EFFECTOR
PROTEIN RABENOSYN-5

(Homo sapiens) 		PF11464
(Rbsn) 		5 GLN B 462
PHE B 469
GLU B 487
ILE B 470
ALA B 473
 None
 1.44A 5entC-1z0kB:
undetectable		 5entC-1z0kB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a87 THIOREDOXIN
REDUCTASE

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 GLY A  26
SER A  22
GLU A  44
ILE A 119
ALA A 286
 None
FAD  A 348 (-3.8A)
None
None
None
 1.07A 5entC-2a87A:
undetectable		 5entC-2a87A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckr ENDOGLUCANASE E-5

(Thermobifida
fusca) 		PF00150
(Cellulase) 		5 SER A 187
GLY A 295
GLU A 263
ILE A 260
ALA A 276
 None
 1.19A 5entC-2ckrA:
undetectable		 5entC-2ckrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		5 PHE A 193
GLY A 190
GLU A 187
ILE A 217
ALA A 218
 None
 1.43A 5entC-2fwrA:
0.0		 5entC-2fwrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		5 GLN A 269
GLY A 191
ASN A 185
ILE A 189
ALA A 197
 None
 1.39A 5entC-2mbgA:
undetectable		 5entC-2mbgA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF12708
(Pectate_lyase_3) 		5 PHE A 198
GLY A 221
SER A 220
GLU A 250
ASN A 270
 None
 1.39A 5entC-2pyhA:
undetectable		 5entC-2pyhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 SER A 276
SER A 253
GLU A 223
ILE A 258
ALA A 261
 None
 1.23A 5entC-2vr2A:
undetectable		 5entC-2vr2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 GLN C   6
SER C 308
GLU C 307
ILE C 344
ALA C 341
 None
 1.36A 5entC-2wbeC:
undetectable		 5entC-2wbeC:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		5 GLN A 591
GLY A1179
ASN A1334
ILE A1030
ALA A1026
 None
 1.40A 5entC-2xkkA:
4.5		 5entC-2xkkA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 PHE D 258
GLY D 407
GLU D 409
ILE D 250
ALA D 254
 None
 1.45A 5entC-2ynmD:
undetectable		 5entC-2ynmD:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zs0 EXTRACELLULAR GIANT
HEMOGLOBIN MAJOR
GLOBIN SUBUNIT B1

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 GLN D  64
GLY D  32
GLU D  28
ILE D 114
ALA D 113
 HEM  D 200 ( 3.6A)
None
None
None
None
 1.30A 5entC-2zs0D:
undetectable		 5entC-2zs0D:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		5 SER A  33
GLY A 174
SER A 179
GLU A 139
ALA A 155
 None
None
None
CTR  A   1 ( 2.4A)
None
 1.37A 5entC-3a3hA:
undetectable		 5entC-3a3hA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 PHE A 306
GLY A 136
SER A 137
ILE A 249
ALA A 254
 None
 1.38A 5entC-3b9eA:
undetectable		 5entC-3b9eA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 PHE A 612
GLY A 608
GLU A 605
ASN A 606
ALA A 615
 None
 1.45A 5entC-3bg9A:
undetectable		 5entC-3bg9A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		5 SER A  75
GLN A 165
PHE A 237
ILE A 238
ALA A 123
 WO4  A 701 (-2.1A)
None
None
None
None
 1.36A 5entC-3cfzA:
undetectable		 5entC-3cfzA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		5 GLN A 161
PHE A 158
GLY A  86
SER A  88
ILE A 411
 None
None
None
EDO  A 474 (-4.0A)
None
 1.35A 5entC-3eu8A:
undetectable		 5entC-3eu8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 GLN P  41
GLY P  10
GLU P  35
ASN P  33
ALA P  17
 None
FAD  P 449 (-3.4A)
FAD  P 449 (-3.4A)
None
None
 1.41A 5entC-3fg2P:
undetectable		 5entC-3fg2P:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtd FUMARATE HYDRATASE
CLASS II

(Rickettsia
prowazekii) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 SER A 143
GLN A  57
ASN A 107
ILE A 110
ALA A 114
 None
 1.33A 5entC-3gtdA:
undetectable		 5entC-3gtdA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm2 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE

(Corynebacterium
diphtheriae) 		no annotation 5 GLY A  34
SER A  33
GLU A  53
ILE A  75
ALA A  49
 None
 1.27A 5entC-3hm2A:
undetectable		 5entC-3hm2A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iie 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Yersinia
pseudotuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 GLY A   8
SER A   9
ASN A  15
ILE A  13
ALA A 123
 None
 1.40A 5entC-3iieA:
undetectable		 5entC-3iieA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		5 SER A 265
GLU A 263
ASN A 262
ILE A 270
ALA A 271
 None
 1.31A 5entC-3ipwA:
undetectable		 5entC-3ipwA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 SER A  97
GLY A  67
GLU A  90
ILE A 141
ALA A 140
 None
 1.36A 5entC-3k8zA:
undetectable		 5entC-3k8zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 SER A  98
GLY A  67
GLU A  91
ILE A 142
ALA A 141
 None
 1.35A 5entC-3k92A:
undetectable		 5entC-3k92A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY A4309
SER A4310
GLU A3994
ILE A3991
ALA A4307
 None
 1.35A 5entC-3kciA:
undetectable		 5entC-3kciA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLN A 130
GLY A 173
SER A 171
ILE A 481
ALA A 179
 None
 1.31A 5entC-3kzwA:
undetectable		 5entC-3kzwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 SER A 207
SER A 564
GLU A 204
ILE A 532
ALA A 544
 None
None
None
None
LYS  A 603 (-3.9A)
 1.41A 5entC-3l76A:
5.8		 5entC-3l76A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 SER A 427
GLY A 261
SER A 260
ILE A 263
ALA A 381
 None
 1.19A 5entC-3ll3A:
undetectable		 5entC-3ll3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwg HP0420 HOMOLOGUE

(Helicobacter
felis) 		no annotation 5 PHE A  55
GLY A  58
SER A  61
ILE A  56
ALA A  53
 None
 1.45A 5entC-3lwgA:
undetectable		 5entC-3lwgA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 SER A 142
PHE A 233
ASN A 121
ILE A 232
ALA A 229
 None
 1.26A 5entC-3omnA:
undetectable		 5entC-3omnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 SER A 200
PHE A 233
ASN A 121
ILE A 232
ALA A 229
 None
 1.29A 5entC-3omnA:
undetectable		 5entC-3omnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		5 GLN A 298
GLY A 326
SER A 341
ILE A 329
ALA A 279
 None
 1.38A 5entC-3q6tA:
undetectable		 5entC-3q6tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		5 SER A  77
GLY A 302
SER A 220
ILE A 213
ALA A 212
 006  A 330 (-2.1A)
None
GOL  A 332 (-3.7A)
None
None
 1.39A 5entC-3qs1A:
undetectable		 5entC-3qs1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		5 SER A 239
GLY A  56
GLU A  84
ILE A  61
ALA A  65
 None
NAD  A 300 ( 3.7A)
NAD  A 300 ( 2.8A)
NAD  A 300 (-3.7A)
None
 1.39A 5entC-3r3sA:
undetectable		 5entC-3r3sA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 SER A 306
GLY A 439
SER A 255
ILE A 441
ALA A 450
 None
 1.43A 5entC-3rreA:
undetectable		 5entC-3rreA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uau SURFACE-EXPOSED
LIPOPROTEIN

(Campylobacter
jejuni) 		PF16668
(JLPA) 		5 GLN A 123
PHE A  66
GLY A  64
ILE A  67
ALA A  68
 None
 1.28A 5entC-3uauA:
undetectable		 5entC-3uauA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdo MFS TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 SER A  92
PHE A  68
GLY A  83
ILE A 116
ALA A 119
 None
 1.39A 5entC-3wdoA:
5.2		 5entC-3wdoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA

(Dictyostelium
discoideum) 		PF01115
(F_actin_cap_B)
PF01267
(F-actin_cap_A) 		5 PHE A 251
GLY A 247
SER A 244
ASN A 242
ILE B 179
 None
 1.42A 5entC-4akrA:
undetectable		 5entC-4akrA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 SER A 282
SER A 259
GLU A 229
ILE A 264
ALA A 267
 None
EDO  A1490 (-3.2A)
None
None
EDO  A1491 ( 3.8A)
 1.20A 5entC-4cnsA:
undetectable		 5entC-4cnsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 SER A 282
SER A 259
GLU A 229
ILE A 264
ALA A 267
 None
 1.17A 5entC-4cntA:
undetectable		 5entC-4cntA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 PHE H 308
GLY H 276
SER H 277
ILE H 311
ALA H 354
 None
 1.13A 5entC-4cr4H:
undetectable		 5entC-4cr4H:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqk POLYMERASE BASIC
PROTEIN 2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 GLN A 383
SER A 405
GLU A 407
ILE A 398
ALA A 397
 None
 1.22A 5entC-4eqkA:
undetectable		 5entC-4eqkA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-RELATED
PROTEIN 7

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 SER A 182
GLY A 396
SER A 397
ILE A 394
ALA A 425
 None
None
PO4  A 503 (-2.2A)
None
None
 1.41A 5entC-4i6mA:
undetectable		 5entC-4i6mA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 PHE A 195
GLY A 178
SER A 147
ILE A 176
ALA A 192
 None
COB  A 301 (-3.6A)
COB  A 301 (-2.7A)
COB  A 301 ( 4.2A)
None
 1.30A 5entC-4jgiA:
undetectable		 5entC-4jgiA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Salmonella
enterica) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 GLN A 151
GLY A 162
GLU A  96
ILE A 166
ALA A 167
 None
 1.35A 5entC-4kh7A:
undetectable		 5entC-4kh7A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0x CHLOROMUCONATE
CYCLOISOMERASE

(Rhodococcus
opacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 276
SER A 101
GLU A  61
ILE A 272
ALA A 281
 None
 1.39A 5entC-4m0xA:
undetectable		 5entC-4m0xA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome) 		PF00150
(Cellulase) 		5 SER A  25
GLY A 165
SER A 170
GLU A 132
ALA A 146
 None
None
None
TRS  A 301 (-2.7A)
None
 1.44A 5entC-4m1rA:
undetectable		 5entC-4m1rA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		5 SER A 394
GLY A 388
SER A 363
ILE A 412
ALA A 427
 None
 1.37A 5entC-4nk6A:
undetectable		 5entC-4nk6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 SER A 843
GLY A 731
SER A 732
GLU A 734
ALA A 652
 None
 1.24A 5entC-4nmeA:
undetectable		 5entC-4nmeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 SER A 130
PHE A  69
GLY A 237
SER A 235
ALA A 243
 None
 1.31A 5entC-4o5pA:
undetectable		 5entC-4o5pA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o79 PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2

(Arabidopsis
thaliana) 		PF03188
(Cytochrom_B561) 		5 SER A 119
GLY A 110
GLU A 112
ASN A 113
ILE A 107
 HEM  A 301 (-4.4A)
None
None
HEM  A 301 (-3.7A)
None
 1.44A 5entC-4o79A:
undetectable		 5entC-4o79A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		5 SER A 394
GLY A 388
SER A 363
ILE A 412
ALA A 427
 None
 1.38A 5entC-4ozyA:
undetectable		 5entC-4ozyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		5 GLN A 171
PHE A 168
GLY A  96
SER A  98
ILE A 421
 None
None
None
None
ACT  A 501 ( 4.7A)
 1.35A 5entC-4qt9A:
undetectable		 5entC-4qt9A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Synechocystis
sp. PCC 6803) 		PF00698
(Acyl_transf_1) 		5 GLY A 161
GLU A 145
ASN A 143
ILE A 159
ALA A 126
 None
 1.36A 5entC-4rr5A:
4.1		 5entC-4rr5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 SER A1624
SER A1375
GLU A1418
ILE A1370
ALA A1330
 None
 1.12A 5entC-4u48A:
undetectable		 5entC-4u48A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1

(Mus musculus) 		no annotation 5 GLN A1360
GLY A1423
GLU A1421
ILE A1410
ALA A1429
 None
 1.18A 5entC-4w8pA:
undetectable		 5entC-4w8pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		5 SER A  33
GLY A 177
SER A 182
GLU A 142
ALA A 158
 None
 1.43A 5entC-4xzbA:
undetectable		 5entC-4xzbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(Geobacillus sp.
70PC53;
uncultured
bacterium) 		PF00150
(Cellulase) 		5 SER A  33
GLY A 176
SER A 181
GLU A 142
ALA A 157
 None
None
None
EPE  A 404 (-3.3A)
None
 1.44A 5entC-4xzwA:
undetectable		 5entC-4xzwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yte H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ0715

(Methanocaldococcus
jannaschii) 		no annotation 5 SER A 184
GLN A 154
GLY A  34
ILE A   5
ALA A   8
 None
 1.33A 5entC-4yteA:
undetectable		 5entC-4yteA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 SER A 762
GLU A 792
ASN A 755
ILE A 679
ALA A 677
 None
 1.40A 5entC-4zdnA:
0.9		 5entC-4zdnA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias) 		PF00287
(Na_K-ATPase) 		5 GLY B 227
SER B 228
GLU B 230
ILE B 276
ALA B 217
 None
None
NAG  B4021 (-3.7A)
None
None
 1.20A 5entC-5aw4B:
undetectable		 5entC-5aw4B:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 SER A  81
GLY A 229
SER A 234
ASN A 187
ALA A 210
 None
None
None
CA  A 643 ( 4.8A)
None
 1.38A 5entC-5ecuA:
undetectable		 5entC-5ecuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 SER A  81
GLY A 229
SER A 234
GLU A 188
ALA A 210
 None
None
None
CA  A 643 (-2.5A)
None
 1.35A 5entC-5ecuA:
undetectable		 5entC-5ecuA:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A  48
GLU A 273
ASN A 274
ILE A 277
ALA A 279
 None
 0.88A 5entC-5enoA:
44.4		 5entC-5enoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 SER A  48
PHE A 178
GLY A 179
SER A 180
GLU A 273
ALA A 279
 None
 1.43A 5entC-5enoA:
44.4		 5entC-5enoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLN X 368
GLY X 328
GLU X 330
ILE X 310
ALA X 159
 None
None
None
None
FAD  X 501 (-4.7A)
 1.35A 5entC-5evyX:
1.5		 5entC-5evyX:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcu JR4 FAB LIGHT CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE L  98
GLY L  99
SER L 100
ILE L  97
ALA L  90
 None
 1.26A 5entC-5fcuL:
undetectable		 5entC-5fcuL:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 GLN A 383
SER A 405
GLU A 407
ILE A 398
ALA A 397
 None
 1.27A 5entC-5fmqA:
undetectable		 5entC-5fmqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 5 SER A 118
GLY A  81
SER A  82
GLU A  99
ALA A  78
 None
 1.14A 5entC-5fzpA:
undetectable		 5entC-5fzpA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		5 GLN A 148
PHE A 145
GLY A  73
SER A  75
ILE A 399
 None
 1.39A 5entC-5gzhA:
undetectable		 5entC-5gzhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 SER A 170
GLY A 438
SER A 163
ILE A 436
ALA A 455
 None
VO4  A 802 (-3.5A)
VO4  A 802 (-2.6A)
None
None
 1.43A 5entC-5hmpA:
undetectable		 5entC-5hmpA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 GLN A 583
GLY A 601
GLU A 500
ASN A 496
ILE A 484
 None
 1.36A 5entC-5i4eA:
undetectable		 5entC-5i4eA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iai SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF01547
(SBP_bac_1) 		5 SER A 278
GLN A  45
GLY A 317
ILE A 100
ALA A 103
 None
RB0  A 501 ( 4.9A)
None
RB0  A 501 (-4.6A)
None
 1.07A 5entC-5iaiA:
undetectable		 5entC-5iaiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		5 SER A  55
GLY A 193
SER A 198
GLU A 159
ALA A 174
 None
 1.42A 5entC-5ihsA:
undetectable		 5entC-5ihsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 GLY B1293
SER B1294
GLU B 943
ILE B1262
ALA B1308
 None
 1.32A 5entC-5jpnB:
undetectable		 5entC-5jpnB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6y TRALOKINUMAB FAB
DIGEST VH

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  33
SER H  97
ASN H  54
ILE H  51
ALA H  78
 None
 1.28A 5entC-5l6yH:
undetectable		 5entC-5l6yH:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 GLN A  22
GLY A  17
SER A  13
ILE A 277
ALA A 463
 None
 1.13A 5entC-5laeA:
1.6		 5entC-5laeA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 GLN A 381
PHE A 383
GLY A 422
SER A 467
ASN A 426
 None
 1.42A 5entC-5n6uA:
undetectable		 5entC-5n6uA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 PHE A 383
GLY A 422
SER A 467
ASN A 426
ILE A 446
 None
 1.30A 5entC-5n6uA:
undetectable		 5entC-5n6uA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkp KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF01344
(Kelch_1) 		5 GLN A 309
GLY A 307
SER A 316
GLU A 318
ALA A 351
 None
 1.28A 5entC-5nkpA:
undetectable		 5entC-5nkpA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G

(Methanothermococcus
thermolithotrophicus) 		PF01058
(Oxidored_q6) 		5 PHE E  82
GLY E  58
ASN E  65
ILE E  56
ALA E  81
 None
SF4  E 302 ( 4.9A)
None
None
ACT  E 301 ( 4.5A)
 1.39A 5entC-5odrE:
undetectable		 5entC-5odrE:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 GLY A 312
SER A 315
GLU A 317
ASN A 310
ALA A 355
 None
None
ZN  A 603 (-2.3A)
None
None
 1.42A 5entC-5tj3A:
undetectable		 5entC-5tj3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 SER 5 170
GLN 5 454
GLU 5 461
ILE 5 509
ALA 5 507
 None
 1.41A 5entC-5udb5:
undetectable		 5entC-5udb5:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 GLN A 673
PHE A 617
ASN A 623
ILE A 621
ALA A 808
 None
 1.35A 5entC-5um6A:
undetectable		 5entC-5um6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 SER A 282
SER A 259
GLU A 229
ILE A 264
ALA A 267
 None
 1.12A 5entC-5uqcA:
undetectable		 5entC-5uqcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uth THIOREDOXIN
REDUCTASE

(Mycolicibacterium
smegmatis) 		PF07992
(Pyr_redox_2) 		5 GLY A  19
SER A  15
GLU A  37
ILE A 111
ALA A 278
 None
FAD  A 400 (-3.6A)
None
None
None
 1.07A 5entC-5uthA:
undetectable		 5entC-5uthA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxi ALDEHYDE
DECARBONYLASE

(Nostoc
punctiforme) 		no annotation 5 GLY A  32
GLU A  38
ASN A  39
ILE A 115
ALA A 119
 DDQ  A 300 ( 4.0A)
None
None
None
DDQ  A 301 ( 3.5A)
 1.07A 5entC-5uxiA:
undetectable		 5entC-5uxiA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC

(Umbellularia
californica) 		no annotation 5 SER A 230
GLY A 238
GLU A 235
ILE A 240
ALA A 243
 None
 1.42A 5entC-5x04A:
undetectable		 5entC-5x04A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 5 GLN C1675
GLU C1585
ASN C1584
ILE C1580
ALA C1576
 None
 1.42A 5entC-5x6oC:
undetectable		 5entC-5x6oC:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 5 PHE A 372
GLY A 373
GLU A 375
ILE A 444
ALA A 481
 None
 1.42A 5entC-6aunA:
undetectable		 5entC-6aunA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6coy CHLORIDE CHANNEL
PROTEIN 1

(Homo sapiens) 		no annotation 5 SER A 175
GLY A 233
SER A 189
ILE A 238
ALA A 239
 None
CL  A1001 (-4.6A)
CL  A1002 (-2.5A)
None
None
 1.42A 5entC-6coyA:
undetectable		 5entC-6coyA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6euv POLYMERASE BASIC
PROTEIN 2

(Influenza A
virus) 		no annotation 5 GLN A 383
SER A 405
GLU A 407
ILE A 398
ALA A 397
 None
 1.20A 5entC-6euvA:
undetectable		 5entC-6euvA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE

(Homo sapiens) 		no annotation 5 GLY A  59
SER A  57
GLU A  56
ILE A  61
ALA A  64
 None
 1.34A 5entC-6fm9A:
1.3		 5entC-6fm9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 5 SER D  93
GLY D  66
GLU D  61
ILE D 322
ALA D  69
 None
 1.33A 5entC-6fmlD:
undetectable		 5entC-6fmlD:
9.51