SIMILAR PATTERNS OF AMINO ACIDS FOR 5EML_A_SAMA701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckm MRNA CAPPING ENZYME

(Paramecium
bursaria
Chlorella virus
1) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 TYR A 111
GLY A  85
GLU A 131
ASP A 213
 None
None
GTP  A 899 (-3.0A)
None
 1.23A 5emlA-1ckmA:
undetectable		 5emlA-1ckmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN

(Thermococcus
litoralis) 		PF01547
(SBP_bac_1) 		4 TYR A 187
GLY A 179
GLU A 239
ASP A  45
 None
TRE  A 563 (-3.5A)
TRE  A 563 (-2.9A)
None
 1.00A 5emlA-1eu8A:
undetectable		 5emlA-1eu8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		4 TYR A 211
TYR A 324
GLY A 262
ASP A 267
 LAF  A1336 ( 3.9A)
LAF  A1337 (-4.6A)
None
None
 1.34A 5emlA-1gzgA:
6.0		 5emlA-1gzgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7p NADH-CYTOCHROME B5
REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 TYR A 112
TYR A  93
GLY A 180
ASP A 239
 FAD  A 301 (-4.2A)
FAD  A 301 (-4.3A)
None
None
 1.28A 5emlA-1i7pA:
3.2		 5emlA-1i7pA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 TYR A  62
TYR A 127
GLY A  79
GLU A  77
 None
 1.12A 5emlA-1pgsA:
undetectable		 5emlA-1pgsA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		4 TYR A 345
TYR A 331
GLY A 379
GLU A 380
 None
 1.29A 5emlA-1q15A:
4.3		 5emlA-1q15A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		4 TYR A 171
GLY A 190
GLU A 213
ASP A 240
 ACT  A 421 ( 4.2A)
SAM  A 635 (-3.8A)
SAM  A 635 (-2.9A)
SAM  A 635 (-3.7A)
 0.96A 5emlA-1qzzA:
8.8		 5emlA-1qzzA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 TYR A 316
GLY A 163
GLU A 199
ASP A 197
 None
TYM  A 501 (-3.6A)
TYM  A 501 (-3.0A)
None
 1.21A 5emlA-1r6uA:
undetectable		 5emlA-1r6uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LYS A 204
TYR A 205
GLY A 161
GLU A 160
 None
None
None
TPP  A1671 (-3.9A)
 0.95A 5emlA-1r9jA:
undetectable		 5emlA-1r9jA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 TYR A  74
TYR A 155
GLY A 341
ASP A 308
 None
 1.25A 5emlA-1up4A:
undetectable		 5emlA-1up4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		4 TYR A 105
TYR A 171
GLY A 102
GLU A 103
 None
 1.26A 5emlA-1xfuA:
undetectable		 5emlA-1xfuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		4 TYR A 358
GLY A 362
GLU A 170
ASP A  21
 None
 1.28A 5emlA-1zmrA:
undetectable		 5emlA-1zmrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ba0 ARCHAEAL EXOSOME RNA
BINDING PROTEIN RRP4

(Archaeoglobus
fulgidus) 		PF00575
(S1)
PF14382
(ECR1_N)
PF15985
(KH_6) 		4 TYR A  53
TYR A  20
GLY A  58
ASP A 128
 None
 1.04A 5emlA-2ba0A:
undetectable		 5emlA-2ba0A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		4 TYR A 279
GLY A 307
GLU A 308
ASP A 173
 None
 1.29A 5emlA-2c0hA:
7.0		 5emlA-2c0hA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A 305
GLY A 258
GLU A  76
ASP A 265
 None
 1.33A 5emlA-2cx9A:
undetectable		 5emlA-2cx9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 TYR A 477
TYR A 447
GLY A 470
GLU A 473
 None
 1.34A 5emlA-2fj0A:
undetectable		 5emlA-2fj0A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR N 456
GLY I 461
GLU I 462
ASP I 207
 None
None
NGT  A  21 (-3.0A)
NGT  A  21 (-3.8A)
 1.00A 5emlA-2gk1N:
4.0		 5emlA-2gk1N:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		no annotation
no annotation
no annotation 		4 TYR I 427
GLY N 490
GLU N 491
ASP M 240
 None
 1.17A 5emlA-2gk1I:
4.0		 5emlA-2gk1I:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 TYR A 141
TYR A 211
GLY A 201
ASP A  19
 None
 1.20A 5emlA-2gksA:
2.8		 5emlA-2gksA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 LYS 1 244
TYR 1 245
GLY 1 472
ASP 1 294
 None
 1.15A 5emlA-2ijd1:
undetectable		 5emlA-2ijd1:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh1 MICRONEMAL PROTEIN 1

(Toxoplasma
gondii) 		PF10564
(MAR_sialic_bdg) 		4 TYR A 203
TYR A 137
GLY A 144
GLU A 165
 None
None
ACT  A1257 ( 3.9A)
None
 0.90A 5emlA-2jh1A:
undetectable		 5emlA-2jh1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A 351
GLY A 303
GLU A 126
ASP A 310
 None
 1.33A 5emlA-2jifA:
undetectable		 5emlA-2jifA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TYR A 463
TYR A  40
GLY A 370
ASP A 338
 None
 1.34A 5emlA-2pwhA:
5.7		 5emlA-2pwhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		4 TYR A 410
GLY A 376
GLU A 404
ASP A 283
 None
 1.20A 5emlA-2v5iA:
undetectable		 5emlA-2v5iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 TYR A  51
GLY A 112
GLU A 114
ASP A 104
 None
 1.04A 5emlA-2vn8A:
6.5		 5emlA-2vn8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 TYR A 614
GLY A 519
GLU A 518
ASP A 498
 None
 1.30A 5emlA-2wanA:
4.0		 5emlA-2wanA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		4 TYR A 304
TYR A 296
GLY A 307
GLU A 306
 None
 1.14A 5emlA-2x1cA:
undetectable		 5emlA-2x1cA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		4 TYR A 254
LYS B 338
TYR B 339
GLY A 263
 None
 1.24A 5emlA-2xsjA:
undetectable		 5emlA-2xsjA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 TYR A 293
TYR A 347
GLY A 367
GLU A 389
 None
None
None
CA  A 621 (-2.5A)
 1.26A 5emlA-2zuyA:
undetectable		 5emlA-2zuyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 TYR A 177
GLY A 198
GLU A 220
ASP A 255
 SPM  A 501 (-4.2A)
MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
 1.30A 5emlA-3c6mA:
3.4		 5emlA-3c6mA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co8 ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 TYR A 208
GLY A 234
GLU A 230
ASP A 240
 None
 1.00A 5emlA-3co8A:
6.6		 5emlA-3co8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Staphylococcus
aureus) 		PF13460
(NAD_binding_10) 		4 TYR A 171
TYR A 106
GLY A 250
ASP A 166
 None
 1.32A 5emlA-3e48A:
2.4		 5emlA-3e48A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpn GEOBACILLUS
STEAROTHERMOPHILUS
UVRA INTERACTION
DOMAIN
GEOBACILLUS
STEAROTHERMOPHILUS
UVRB INTERACTION
DOMAIN

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		no annotation
no annotation 		4 LYS A 226
GLY A 173
GLU B 201
ASP B 228
 None
 1.25A 5emlA-3fpnA:
undetectable		 5emlA-3fpnA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		4 TYR A  34
GLY A  53
GLU A  74
ASP A  97
 None
 1.08A 5emlA-3hnrA:
5.6		 5emlA-3hnrA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		4 TYR A 426
TYR A 272
GLU A 162
ASP A 159
 None
 1.17A 5emlA-3hq2A:
undetectable		 5emlA-3hq2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LYS A 156
TYR A 158
GLY A 127
ASP A 288
 None
 1.31A 5emlA-3ip3A:
2.3		 5emlA-3ip3A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju5 ARGININE KINASE

(Apostichopus
japonicus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 TYR A  87
TYR A  73
GLY A  64
ASP A  60
 None
 1.13A 5emlA-3ju5A:
undetectable		 5emlA-3ju5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		4 LYS A 169
TYR A 170
GLY A 260
GLU A 263
 None
 1.30A 5emlA-3jujA:
undetectable		 5emlA-3jujA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN

(Klebsiella
pneumoniae) 		PF00149
(Metallophos) 		4 TYR A 122
GLY A 100
GLU A 103
ASP A  16
 None
None
None
MN  A 340 (-3.2A)
 1.32A 5emlA-3jyfA:
undetectable		 5emlA-3jyfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 LYS A 315
TYR A 323
GLY A 302
ASP A 211
 None
 1.22A 5emlA-3ll7A:
6.6		 5emlA-3ll7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 TYR A 242
GLY A 585
GLU A 588
ASP A 698
 None
 1.27A 5emlA-3lppA:
4.3		 5emlA-3lppA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngx BIFUNCTIONAL PROTEIN
FOLD

(Thermoplasma
acidophilum) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A  44
TYR A 225
GLY A 254
ASP A 141
 None
 1.22A 5emlA-3ngxA:
2.3		 5emlA-3ngxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61

(Homo sapiens) 		PF00400
(WD40) 		4 TYR A 301
TYR A 282
GLY A 279
ASP A 294
 None
None
UNX  A 307 ( 3.9A)
UNX  A1001 ( 3.5A)
 1.27A 5emlA-3ow8A:
undetectable		 5emlA-3ow8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 TYR A  28
GLY A  66
GLU A 101
ASP A 156
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
 0.96A 5emlA-3ps9A:
6.1		 5emlA-3ps9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
NUCLEOTIDE EXCHANGE
FACTOR SIL1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00012
(HSP70)
PF16782
(SIL1) 		4 LYS C 166
TYR C 165
GLY A 384
ASP A 244
 None
 1.25A 5emlA-3qmlC:
undetectable		 5emlA-3qmlC:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TYR A  65
TYR A  28
GLY A  68
GLU A  51
 None
 1.17A 5emlA-3qwbA:
5.5		 5emlA-3qwbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00160
(Pro_isomerase) 		4 TYR A 109
TYR A 399
GLU A 126
ASP A 130
 None
 1.30A 5emlA-3rfyA:
undetectable		 5emlA-3rfyA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 TYR A 386
GLY A 414
GLU A 450
ASP A 477
 None
 0.60A 5emlA-3ua4A:
38.3		 5emlA-3ua4A:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300

(Pyrococcus
horikoshii) 		PF01171
(ATP_bind_3) 		4 TYR A  16
LYS A  33
TYR A  29
GLU A 239
 None
 1.28A 5emlA-3vrhA:
undetectable		 5emlA-3vrhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		4 TYR A 264
GLY A 292
GLU A 293
ASP A 158
 TRS  A 401 ( 4.8A)
None
TRS  A 401 (-2.7A)
None
 1.31A 5emlA-3vupA:
3.7		 5emlA-3vupA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE

(Caldanaerobius
polysaccharolyticus) 		PF00150
(Cellulase) 		4 TYR A 198
TYR A 241
GLY A 178
GLU A 137
 TRS  A 401 ( 4.9A)
None
None
TRS  A 401 (-2.7A)
 1.26A 5emlA-3w0kA:
3.9		 5emlA-3w0kA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LYS B1755
TYR B1751
GLY B1631
ASP B1628
 None
 1.33A 5emlA-3zefB:
2.6		 5emlA-3zefB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 204
GLY A 442
GLU A 441
ASP A 370
 None
 1.33A 5emlA-3zz1A:
4.1		 5emlA-3zz1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 TYR A  89
TYR A  75
GLY A  66
ASP A  62
 None
None
ARG  A 400 (-3.8A)
None
 1.16A 5emlA-4bhlA:
undetectable		 5emlA-4bhlA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		4 TYR A 672
TYR A 130
GLY A 709
ASP A 746
 GAL  A1795 ( 4.2A)
None
None
GOL  A1798 (-3.8A)
 1.09A 5emlA-4bq4A:
2.7		 5emlA-4bq4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY

(Staphylococcus
aureus) 		PF00877
(NLPC_P60)
PF13702
(Lysozyme_like) 		4 TYR A 197
TYR A 176
GLU A  83
ASP A  90
 None
 1.29A 5emlA-4fdyA:
undetectable		 5emlA-4fdyA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 TYR A 317
GLY A 299
GLU A 300
ASP A 343
 None
 1.27A 5emlA-4fixA:
undetectable		 5emlA-4fixA:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 TYR A 320
GLY A 361
GLU A 388
ASP A 415
 SAH  A 701 (-4.3A)
SAH  A 701 (-3.3A)
SAH  A 701 (-2.5A)
SAH  A 701 (-2.8A)
 0.48A 5emlA-4g56A:
48.4		 5emlA-4g56A:
80.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl6 HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		PF16440
(DUF5037) 		4 TYR A  98
TYR A  36
GLY A  42
GLU A  43
 None
 1.17A 5emlA-4gl6A:
undetectable		 5emlA-4gl6A:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		6 TYR A 324
LYS A 333
TYR A 334
GLY A 365
GLU A 392
ASP A 419
 0XU  A 701 (-4.3A)
0XU  A 701 (-3.0A)
0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.17A 5emlA-4gqbA:
56.2		 5emlA-4gqbA:
98.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7

(Clostridioides
difficile) 		PF00877
(NLPC_P60)
PF13702
(Lysozyme_like) 		4 TYR A 196
TYR A 175
GLU A  81
ASP A  88
 GOL  A 406 ( 4.5A)
None
GOL  A 406 (-2.9A)
None
 1.28A 5emlA-4hpeA:
undetectable		 5emlA-4hpeA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 248
GLY A 510
GLU A 509
ASP A 437
 BGC  A 943 ( 4.5A)
None
BGC  A 942 (-3.1A)
BGC  A 943 ( 4.8A)
 1.33A 5emlA-4iigA:
3.9		 5emlA-4iigA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 TYR A  73
TYR A  49
GLY A  53
ASP A 184
 None
 1.28A 5emlA-4jypA:
2.1		 5emlA-4jypA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		4 TYR A 216
TYR A  60
GLY A 133
ASP A 160
 None
 1.25A 5emlA-4k3fA:
undetectable		 5emlA-4k3fA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 TYR A 348
TYR A 300
GLY A 378
GLU A 437
 None
 1.32A 5emlA-4maeA:
undetectable		 5emlA-4maeA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 TYR A 249
TYR A  86
GLY A 254
GLU A 324
 None
 1.16A 5emlA-4mguA:
undetectable		 5emlA-4mguA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 LYS A 420
GLY A 479
GLU A 481
ASP A 812
 None
 1.31A 5emlA-4n3sA:
2.2		 5emlA-4n3sA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		4 TYR A 592
TYR A 636
GLY A 504
ASP A 403
 None
 1.32A 5emlA-4nj5A:
undetectable		 5emlA-4nj5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pux UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF11578
(DUF3237) 		4 LYS A 150
TYR A 151
GLY A  68
GLU A  67
 None
 1.14A 5emlA-4puxA:
undetectable		 5emlA-4puxA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified) 		PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3) 		4 TYR A 137
GLY A  41
GLU A  51
ASP A  49
 None
F  A 302 ( 4.2A)
None
None
 1.26A 5emlA-4q3kA:
2.3		 5emlA-4q3kA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 TYR A 232
GLY A  12
GLU A  44
ASP A  37
 None
CL  A 402 ( 4.1A)
None
None
 1.33A 5emlA-4q3nA:
undetectable		 5emlA-4q3nA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 TYR A 549
GLY A 604
GLU A 603
ASP A 535
 None
 1.34A 5emlA-4qi4A:
undetectable		 5emlA-4qi4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 TYR A 549
GLY A 604
GLU A 603
ASP A 535
 None
 1.27A 5emlA-4qi6A:
undetectable		 5emlA-4qi6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 TYR A  93
TYR A  79
GLY A  70
ASP A  66
 None
None
ARG  A 805 (-3.8A)
None
 1.13A 5emlA-4rf7A:
undetectable		 5emlA-4rf7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT V,
CHLOROPLASTIC

(Pisum sativum;
Pisum sativum) 		PF00223
(PsaA_PsaB)
PF01241
(PSI_PSAK) 		4 TYR B 323
GLY G  98
GLU G  93
ASP G 102
 CLA  B1221 (-4.0A)
None
None
None
 1.24A 5emlA-4rkuB:
undetectable		 5emlA-4rkuB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl4 GTP CYCLOHYDROLASE-2

(Helicobacter
pylori) 		PF00925
(GTP_cyclohydro2) 		4 LYS A 154
TYR A 130
GLY A  93
GLU A  92
 PPV  A 201 (-2.8A)
None
None
None
 1.35A 5emlA-4rl4A:
undetectable		 5emlA-4rl4A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		4 TYR A  68
TYR A  86
GLY A 105
ASP A 249
 None
 1.31A 5emlA-4y7dA:
undetectable		 5emlA-4y7dA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		4 TYR A 368
GLY A 372
GLU A 170
ASP A  21
 None
 1.15A 5emlA-5bt8A:
3.9		 5emlA-5bt8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 TYR B 462
TYR B  40
GLY B 370
ASP B 339
 None
 1.34A 5emlA-5do8B:
3.7		 5emlA-5do8B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN

(Yersinia pestis) 		PF00149
(Metallophos) 		4 TYR A 145
GLY A 123
GLU A 126
ASP A  39
 None
None
None
FE  A 402 (-3.1A)
 1.32A 5emlA-5eqvA:
undetectable		 5emlA-5eqvA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 TYR A 253
GLY A  58
GLU A  57
ASP A 494
 None
 1.32A 5emlA-5ev7A:
undetectable		 5emlA-5ev7A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		4 TYR A  23
GLY A  38
GLU A  39
ASP A  83
 None
 1.34A 5emlA-5fa1A:
2.3		 5emlA-5fa1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 249
GLY A 511
GLU A 510
ASP A 438
 None
None
EDO  A1872 ( 4.9A)
EDO  A1872 ( 4.8A)
 1.27A 5emlA-5fjiA:
2.5		 5emlA-5fjiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 249
GLY A 511
GLU A 510
ASP A 438
 None
None
None
PEG  A6002 ( 4.4A)
 1.32A 5emlA-5fjjA:
3.0		 5emlA-5fjjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzs GGDEF FAMILY PROTEIN

(Vibrio cholerae) 		PF00497
(SBP_bac_3) 		4 TYR A 281
TYR A 353
GLU A 276
ASP A 324
 None
 1.28A 5emlA-5gzsA:
2.1		 5emlA-5gzsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 245
GLY A 506
GLU A 505
ASP A 433
 BGC  A 946 (-4.7A)
None
BGC  A 946 (-3.3A)
None
 1.33A 5emlA-5ju6A:
2.7		 5emlA-5ju6A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII) 		4 TYR C 395
GLY C 102
GLU C 300
ASP C 187
 None
 1.33A 5emlA-5mdxC:
undetectable		 5emlA-5mdxC:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz8 ALDEHYDE
DEHYDROGENASE 21

(Physcomitrella
patens) 		PF00171
(Aldedh) 		4 TYR A 296
TYR A 340
GLY A 117
ASP A 124
 SIN  A 501 (-4.7A)
None
None
None
 1.10A 5emlA-5mz8A:
3.2		 5emlA-5mz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 TYR A 244
GLY A 506
GLU A 505
ASP A 432
 None
 1.25A 5emlA-5nbsA:
3.0		 5emlA-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L24,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		PF00467
(KOW)
PF17136
(ribosomal_L24)
PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 LYS d 207
TYR d 209
GLY V  90
GLU V 112
 None
 1.15A 5emlA-5oold:
undetectable		 5emlA-5oold:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3

(Saccharomyces
cerevisiae) 		PF08238
(Sel1) 		4 TYR A 507
GLY A 594
GLU A 552
ASP A 597
 None
 0.73A 5emlA-5v7vA:
undetectable		 5emlA-5v7vA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 4 TYR A 179
GLY A  97
GLU A 135
ASP A 106
 None
 1.31A 5emlA-5vqdA:
5.8		 5emlA-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 TYR A 365
GLY A 269
GLU A 268
ASP A 246
 None
None
CA  A 717 (-2.7A)
None
 1.34A 5emlA-5ww1A:
4.9		 5emlA-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 TYR A 248
TYR A 231
GLY A 149
GLU A 144
 None
EDO  A1801 (-3.2A)
None
None
 1.08A 5emlA-5x7sA:
3.1		 5emlA-5x7sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN

(Shewanella
loihica) 		no annotation 4 TYR A  59
LYS A 307
GLY A  82
ASP A 161
 None
 1.16A 5emlA-5x8zA:
undetectable		 5emlA-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 4 TYR A 181
GLY A 208
GLU A 229
ASP A 295
 None
SAM  A 505 (-3.3A)
SAM  A 505 (-2.9A)
SAM  A 505 (-3.6A)
 0.84A 5emlA-5yf0A:
8.8		 5emlA-5yf0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 4 TYR A 214
TYR A 201
GLY A 308
ASP A 124
 None
 1.35A 5emlA-6b82A:
undetectable		 5emlA-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 4 TYR A 385
TYR A 429
GLY A 444
ASP A 290
 None
 1.35A 5emlA-6bbpA:
2.0		 5emlA-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d1q RNA
PYROPHOSPHOHYDROLASE

(Escherichia
coli) 		no annotation 4 LYS B 140
TYR B 144
GLY B  38
GLU B  53
 None
 1.25A 5emlA-6d1qB:
undetectable		 5emlA-6d1qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC

(Acetobacterium
woodii) 		no annotation 4 TYR C 299
GLY C 251
GLU C  73
ASP C 258
 None
 1.35A 5emlA-6fahC:
undetectable		 5emlA-6fahC:
undetectable