SIMILAR PATTERNS OF AMINO ACIDS FOR 5EML_A_SAMA701_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 648
GLY A 644
ASN A 641
LEU A 671
CYH A 714
 None
 1.37A 5emlA-1dgjA:
undetectable		 5emlA-1dgjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		5 LEU A 186
GLY A 235
PRO A 275
LEU A 274
ARG A 182
 None
 1.21A 5emlA-1f2jA:
5.3		 5emlA-1f2jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gaj HIGH-AFFINITY
BRANCHED CHAIN AMINO
ACID TRANSPORT
ATP-BINDING PROTEIN

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		5 LEU A 115
GLY A 106
LEU A 103
ASN A 109
LEU A  94
 None
 1.28A 5emlA-1gajA:
undetectable		 5emlA-1gajA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 GLY A 403
PRO A 320
LEU A 407
ASN A 474
LEU A 420
 None
 1.39A 5emlA-1h79A:
2.6		 5emlA-1h79A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 273
GLY A 280
PRO A 228
LEU A 227
LEU A  29
 None
 1.31A 5emlA-1kvkA:
undetectable		 5emlA-1kvkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 PRO A 138
LEU A 137
GLY A 338
LEU A 318
LEU A 234
 None
 0.97A 5emlA-1kvkA:
undetectable		 5emlA-1kvkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ln4 HYPOTHETICAL PROTEIN
YHBY

(Escherichia
coli) 		PF01985
(CRS1_YhbY) 		5 LEU A   3
GLY A  13
PRO A  17
LEU A  18
CYH A  73
 None
 1.30A 5emlA-1ln4A:
2.8		 5emlA-1ln4A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 GLY A 349
PRO A 353
LEU A 354
LEU A 230
CYH A 260
 None
 1.44A 5emlA-1mb9A:
2.8		 5emlA-1mb9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		5 PRO A 376
LEU A 375
LEU A 381
LYS A 235
GLU A 213
 None
 1.35A 5emlA-1ndfA:
undetectable		 5emlA-1ndfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)

(Caenorhabditis
elegans) 		PF01633
(Choline_kinase) 		5 LEU A 159
GLY A  84
LEU A  89
ARG A 157
LEU A 262
 None
 1.39A 5emlA-1nw1A:
undetectable		 5emlA-1nw1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od5 GLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		5 PRO A 489
GLY A 378
LEU A 439
ASN A 345
GLU A 432
 None
 1.41A 5emlA-1od5A:
undetectable		 5emlA-1od5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A   8
GLY A  37
PRO A  77
LEU A  78
LEU A  10
 None
 1.27A 5emlA-1odoA:
undetectable		 5emlA-1odoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 GLY A 351
LEU A 307
ASN A 353
ARG A 361
LEU A 297
 None
 1.50A 5emlA-1qk1A:
undetectable		 5emlA-1qk1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica;
Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLY C  43
LEU C  59
ASN A 690
MET A 191
ARG C 136
 None
FES  C1908 ( 4.2A)
None
None
None
 1.28A 5emlA-1sb3C:
undetectable		 5emlA-1sb3C:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A

(Rattus
norvegicus) 		PF00625
(Guanylate_kin) 		5 PRO B 326
LEU B 329
GLY B 233
LEU B 387
ASN B 324
 None
 1.43A 5emlA-1t0hB:
undetectable		 5emlA-1t0hB:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU D 163
PRO D 146
LEU D 120
ASN D 169
LEU D 139
 None
 1.43A 5emlA-1u0nD:
undetectable		 5emlA-1u0nD:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 PRO D 164
LEU D 163
PRO D 146
LEU D 120
ASN D 169
 None
 1.16A 5emlA-1u0nD:
undetectable		 5emlA-1u0nD:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 LEU A 182
GLY A  48
LEU A  44
LYS A  51
ASN A  75
 PLP  A 413 (-4.5A)
None
None
PLP  A 413 (-1.3A)
PLP  A 413 (-3.9A)
 1.40A 5emlA-1ve5A:
2.7		 5emlA-1ve5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyv CALCIUM CHANNEL
BETA-4SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 PRO A 318
LEU A 321
GLY A 225
LEU A 378
ASN A 316
 None
 1.41A 5emlA-1vyvA:
undetectable		 5emlA-1vyvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		5 LEU A 357
GLY A 338
LEU A 287
ARG A 236
GLU A 335
 None
None
None
None
SRP  A 900 (-2.8A)
 1.17A 5emlA-1wleA:
undetectable		 5emlA-1wleA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		5 LEU A 183
GLY A  61
LEU A  57
ARG A 179
LEU A  28
 None
 1.23A 5emlA-2c2qA:
undetectable		 5emlA-2c2qA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 PRO A 496
GLY A 552
ASN A 501
ARG A 563
GLU A 558
 None
 1.08A 5emlA-2d3tA:
4.4		 5emlA-2d3tA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		5 GLY A 336
PRO A 316
LEU A 306
ASN A 145
LEU A 136
 None
 1.30A 5emlA-2dw6A:
2.9		 5emlA-2dw6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		5 GLY A 336
PRO A 316
LEU A 306
MET A 327
LEU A 136
 None
 1.41A 5emlA-2dw6A:
2.9		 5emlA-2dw6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2goy ADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01507
(PAPS_reduct) 		5 PRO A 230
GLY A  88
PRO A 114
LEU A 119
LEU A 128
 SF4  A 301 ( 4.6A)
None
None
None
None
 1.20A 5emlA-2goyA:
3.3		 5emlA-2goyA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 PRO A 495
LEU A 255
GLY A 220
MET A 268
LEU A 197
 None
 1.47A 5emlA-2i0kA:
undetectable		 5emlA-2i0kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		5 PRO A 234
LEU A 208
GLY A 168
GLU A 200
LEU A 206
 None
 1.39A 5emlA-2imrA:
5.6		 5emlA-2imrA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		5 LEU A 264
GLY A 163
LEU A 189
ASN A 232
LEU A 222
 None
 1.46A 5emlA-2oodA:
3.1		 5emlA-2oodA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or0 HYDROXYLASE

(Rhodococcus
jostii) 		PF08028
(Acyl-CoA_dh_2) 		5 PRO A  47
GLY A 101
ASN A 104
MET A 108
LEU A  88
 None
 1.00A 5emlA-2or0A:
undetectable		 5emlA-2or0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 PRO A 138
LEU A 137
GLY A 338
LEU A 318
LEU A 234
 None
 1.08A 5emlA-2r3vA:
undetectable		 5emlA-2r3vA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r44 UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF07726
(AAA_3) 		5 LEU A  71
PRO A  54
LEU A  50
ASN A  63
LEU A 151
 None
 1.30A 5emlA-2r44A:
undetectable		 5emlA-2r44A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF02390
(Methyltransf_4) 		5 GLY E 212
PRO E 281
LEU E 280
LYS E 177
LEU E 241
 None
 1.11A 5emlA-2vdvE:
4.0		 5emlA-2vdvE:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		5 LEU A  82
PRO A 167
LEU A 166
GLU A 146
CYH A 151
 None
 1.43A 5emlA-2w3pA:
undetectable		 5emlA-2w3pA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 PRO A  30
LEU A  44
PRO A 272
LEU A 256
ARG A 246
 None
None
FNR  A1330 (-4.5A)
None
None
 1.39A 5emlA-2ymvA:
undetectable		 5emlA-2ymvA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq1 ORF73

(Murid
gammaherpesvirus
4) 		no annotation 5 PRO A 140
LEU A 139
MET A 146
ARG A 147
CYH A 188
 None
 1.46A 5emlA-2yq1A:
undetectable		 5emlA-2yq1A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Homo sapiens) 		PF02732
(ERCC4) 		5 GLY B 265
LEU B 261
LYS B 430
LEU B 273
CYH B 437
 None
 1.27A 5emlA-2ziuB:
undetectable		 5emlA-2ziuB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 PRO A 346
LEU A 343
GLY A 167
LEU A 271
MET A 331
 None
 1.27A 5emlA-2zxhA:
undetectable		 5emlA-2zxhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE

(Bradyrhizobium
japonicum) 		PF00561
(Abhydrolase_1) 		5 LEU A 275
GLY A 184
LEU A 181
MET A 126
GLU A 284
 None
 1.43A 5emlA-3a2lA:
undetectable		 5emlA-3a2lA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE

(Bradyrhizobium
japonicum) 		PF00561
(Abhydrolase_1) 		5 LEU A 275
GLY A 184
PRO A 182
LEU A 181
GLU A 284
 None
 1.44A 5emlA-3a2lA:
undetectable		 5emlA-3a2lA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		5 PRO A 117
GLY A 174
LEU A 144
ASN A 171
GLU A 140
 None
None
None
0JO  A 401 (-3.6A)
None
 1.48A 5emlA-3b1eA:
undetectable		 5emlA-3b1eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 LEU A 152
LEU A 174
MET A 190
LEU A 179
CYH A 183
 None
 1.12A 5emlA-3b3dA:
4.0		 5emlA-3b3dA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjy PUTATIVE
THIOESTERASE

(Novosphingobium
aromaticivorans) 		PF13622
(4HBT_3) 		5 LEU A 239
PRO A 136
LEU A 135
LEU A 167
CYH A 219
 None
 1.38A 5emlA-3cjyA:
undetectable		 5emlA-3cjyA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 PRO A  99
LEU A  71
ASN A  77
LEU A  64
CYH A  56
 None
 1.27A 5emlA-3cvrA:
undetectable		 5emlA-3cvrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 LEU A  56
GLY A 130
PRO A 134
ASN A  63
ARG A 312
 None
 1.23A 5emlA-3djlA:
undetectable		 5emlA-3djlA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 LEU A 274
GLY A  18
LEU A  16
ARG A 250
LEU A 291
 None
 1.45A 5emlA-3dwiA:
3.4		 5emlA-3dwiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 GLY P   8
LEU P 104
ASN P  33
ARG P  28
LEU P  89
 FAD  P 449 (-3.3A)
None
None
None
None
 1.41A 5emlA-3fg2P:
3.5		 5emlA-3fg2P:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1

(Streptomyces
antibioticus) 		PF16670
(PI-PLC-C1) 		5 LEU A  58
MET A 111
GLU A  60
LEU A  61
CYH A 107
 None
 1.11A 5emlA-3h4xA:
2.0		 5emlA-3h4xA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn0 NITRATE TRANSPORT
PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 PRO A 112
LEU A 113
GLY A 161
LEU A 159
ARG A 165
 None
 1.36A 5emlA-3hn0A:
undetectable		 5emlA-3hn0A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsw EXCRETORY-SECRETORY
PROTEIN 2

(Ancylostoma
ceylanicum) 		no annotation 5 LEU A  67
GLY A  56
PRO A  53
ASN A  35
LEU A  75
 None
 1.35A 5emlA-3nswA:
undetectable		 5emlA-3nswA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 315
GLY A 264
ASN A 338
GLU A  96
LEU A  92
 None
None
None
EDO  A 413 (-4.7A)
EDO  A 413 ( 4.6A)
 1.41A 5emlA-3sf6A:
undetectable		 5emlA-3sf6A:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		6 GLY A 415
LYS A 451
ARG A 479
GLU A 499
LEU A 500
CYH A 513
 None
 1.00A 5emlA-3ua4A:
38.3		 5emlA-3ua4A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		6 GLY A 415
PRO A 419
LYS A 451
GLU A 499
LEU A 500
CYH A 513
 None
 1.35A 5emlA-3ua4A:
38.3		 5emlA-3ua4A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		8 GLY A 416
LYS A 451
ASN A 452
MET A 478
ARG A 479
GLU A 499
LEU A 500
CYH A 513
 None
 0.79A 5emlA-3ua4A:
38.3		 5emlA-3ua4A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		8 GLY A 416
PRO A 419
LYS A 451
ASN A 452
MET A 478
GLU A 499
LEU A 500
CYH A 513
 None
 0.78A 5emlA-3ua4A:
38.3		 5emlA-3ua4A:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 LEU A 404
GLY A 985
PRO A 988
LEU A 989
LEU A 400
 None
 1.03A 5emlA-3w9hA:
undetectable		 5emlA-3w9hA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 PRO A 104
GLY A 249
LEU A  75
ARG A 112
LEU A 100
 None
 1.40A 5emlA-3wafA:
2.1		 5emlA-3wafA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PRO A 650
LEU A 625
LEU A 658
ASN A 648
LEU A 631
 None
 1.49A 5emlA-3wpeA:
undetectable		 5emlA-3wpeA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 GLY A 420
LEU A 386
ASN A 440
ARG A 360
LEU A 372
 None
None
None
NAG  A1442 ( 4.7A)
None
 1.45A 5emlA-3zyiA:
undetectable		 5emlA-3zyiA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 GLY A 531
PRO A 517
LEU A 515
ASN A 529
ARG A 460
 None
 1.36A 5emlA-4d8mA:
undetectable		 5emlA-4d8mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		5 GLY A  31
LEU A  33
MET A  23
ARG A  27
LEU A  65
 None
 1.49A 5emlA-4emkA:
undetectable		 5emlA-4emkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 340
PRO A 495
LEU A 324
ASN A 333
LEU A 464
 None
 1.44A 5emlA-4fdhA:
undetectable		 5emlA-4fdhA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		11 PRO A 310
LEU A 311
GLY A 363
LEU A 367
LYS A 389
ASN A 390
MET A 416
ARG A 417
GLU A 431
LEU A 432
CYH A 445
 None
SAH  A 701 (-4.1A)
SAH  A 701 ( 4.1A)
None
SAH  A 701 (-4.0A)
None
SAH  A 701 (-4.3A)
SAH  A 701 ( 4.7A)
SAH  A 701 (-3.1A)
SAH  A 701 (-4.5A)
SAH  A 701 (-3.4A)
 0.47A 5emlA-4g56A:
48.6		 5emlA-4g56A:
80.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		11 PRO A 310
LEU A 311
GLY A 363
PRO A 366
LEU A 367
LYS A 389
ASN A 390
MET A 416
GLU A 431
LEU A 432
CYH A 445
 None
SAH  A 701 (-4.1A)
SAH  A 701 ( 4.1A)
None
None
SAH  A 701 (-4.0A)
None
SAH  A 701 (-4.3A)
SAH  A 701 (-3.1A)
SAH  A 701 (-4.5A)
SAH  A 701 (-3.4A)
 0.53A 5emlA-4g56A:
48.6		 5emlA-4g56A:
80.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		12 PRO A 314
LEU A 315
GLY A 367
PRO A 370
LEU A 371
LYS A 393
ASN A 394
MET A 420
ARG A 421
GLU A 435
LEU A 436
CYH A 449
 None
0XU  A 701 (-3.9A)
0XU  A 701 ( 3.7A)
0XU  A 701 (-4.2A)
0XU  A 701 (-4.3A)
0XU  A 701 (-3.9A)
None
0XU  A 701 (-4.4A)
0XU  A 701 ( 4.9A)
0XU  A 701 (-4.2A)
None
0XU  A 701 (-3.6A)
 0.36A 5emlA-4gqbA:
56.2		 5emlA-4gqbA:
98.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 LEU A 186
GLY A  44
LEU A  27
GLU A 190
CYH A 196
 None
None
GOL  A 603 ( 4.1A)
NAD  A 601 ( 2.9A)
None
 1.18A 5emlA-4i8pA:
3.8		 5emlA-4i8pA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 PRO A 106
LEU A  74
GLY A 352
LEU A 365
ASN A  72
 None
 1.31A 5emlA-4im4A:
8.1		 5emlA-4im4A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00884
(Sulfatase) 		5 PRO A 473
GLY A 458
LEU A 415
ASN A 460
GLU A 455
 None
 1.33A 5emlA-4kavA:
undetectable		 5emlA-4kavA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PRO A 357
LEU A 356
GLY A 337
LEU A 342
LEU A 370
 None
 1.43A 5emlA-4m7eA:
undetectable		 5emlA-4m7eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 PRO A  92
GLY A  86
MET A 131
GLU A 235
LEU A  90
 None
None
None
BDP  A 402 (-3.0A)
None
 1.30A 5emlA-4ovqA:
undetectable		 5emlA-4ovqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 PRO A 232
LEU A 207
LEU A 240
ASN A 230
LEU A 213
 None
 1.40A 5emlA-4qdhA:
undetectable		 5emlA-4qdhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		5 LEU A 171
GLY A  90
LEU A  96
ARG A 174
GLU A 155
 None
SAH  A1000 (-3.2A)
SAH  A1000 (-4.0A)
None
None
 1.40A 5emlA-4qppA:
25.6		 5emlA-4qppA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u06 LIC10831

(Leptospira
interrogans) 		PF12799
(LRR_4)
PF13855
(LRR_8) 		5 PRO A  85
LEU A  84
GLY A  66
LEU A  42
GLU A  64
 None
 1.36A 5emlA-4u06A:
undetectable		 5emlA-4u06A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		5 PRO A  46
LEU A  45
GLY A 288
ASN A 137
LEU A 107
 None
 1.48A 5emlA-4w7gA:
2.7		 5emlA-4w7gA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9u ACYL-COA
DEHYDROGENASE

(Brucella
abortus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 310
GLY A 259
ASN A 333
GLU A  88
LEU A  84
 None
 1.45A 5emlA-4w9uA:
undetectable		 5emlA-4w9uA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Sinorhizobium
meliloti) 		PF00496
(SBP_bac_5) 		5 LEU A 482
LEU A 275
ASN A 319
LEU A 449
CYH A 437
 None
 1.42A 5emlA-4wedA:
undetectable		 5emlA-4wedA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru PNKP1

(Capnocytophaga
gingivalis) 		PF13671
(AAA_33) 		5 GLY A 186
LEU A 184
ASN A 308
ARG A 297
CYH A 304
 MG  A 401 ( 4.7A)
None
None
None
None
 1.30A 5emlA-4xruA:
2.1		 5emlA-4xruA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		5 GLY A 433
PRO A  16
LEU A  66
ASN A 431
LEU A 436
 None
 1.47A 5emlA-4y0iA:
3.0		 5emlA-4y0iA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 219
PRO A 261
LEU A 236
ASN A 242
LEU A 225
 None
 1.21A 5emlA-4z64A:
undetectable		 5emlA-4z64A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zw2 VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1,VOLTAGE-DEPEN
DENT L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1

(Mus musculus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 PRO A 245
LEU A 248
GLY A 152
LEU A 305
ASN A 243
 None
 1.42A 5emlA-4zw2A:
undetectable		 5emlA-4zw2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 LEU A  78
GLY A 297
PRO A 278
LEU A 279
LEU A  37
 None
 1.49A 5emlA-5fyaA:
undetectable		 5emlA-5fyaA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASB

(Escherichia
coli) 		PF09485
(CRISPR_Cse2) 		5 PRO B 126
LEU B  87
GLY B  95
ASN B  93
LEU B 120
 None
 1.49A 5emlA-5h9fB:
undetectable		 5emlA-5h9fB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 PRO A 152
LEU A 151
GLY A 245
LEU A 101
CYH A  80
 None
 1.31A 5emlA-5hdjA:
undetectable		 5emlA-5hdjA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1

(Homo sapiens) 		PF01273
(LBP_BPI_CETP) 		5 PRO A  72
LEU A  73
GLY A 221
PRO A 225
LEU A 226
 None
 1.29A 5emlA-5i7kA:
undetectable		 5emlA-5i7kA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		5 LEU A  87
GLY A 101
ASN A 100
LEU A 121
CYH A 211
 None
 1.30A 5emlA-5ipxA:
undetectable		 5emlA-5ipxA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1

(Mus musculus) 		PF01825
(GPS) 		5 LEU A 298
GLY A 314
LEU A 289
GLU A 213
LEU A 212
 None
 1.31A 5emlA-5kvmA:
undetectable		 5emlA-5kvmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzy SMOOTHENED

(Xenopus laevis) 		PF01392
(Fz) 		5 GLY A 135
PRO A 137
LEU A 140
ARG A  90
LEU A  85
 None
CY8  A1201 ( 4.9A)
None
None
CY8  A1201 (-4.1A)
 1.47A 5emlA-5kzyA:
undetectable		 5emlA-5kzyA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 LEU A 646
PRO A 577
LEU A 576
MET A 625
GLU A 588
 None
 1.32A 5emlA-5lq3A:
undetectable		 5emlA-5lq3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mau CHLORITE DISMUTASE

(Cyanothece sp.
PCC 7425) 		no annotation 5 GLY A   9
LEU A  28
ASN A  35
ARG A 128
LEU A  87
 None
None
None
GOL  A 204 (-3.7A)
None
 1.38A 5emlA-5mauA:
undetectable		 5emlA-5mauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovl 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A  31
PRO A  60
LEU A  63
ASN A  96
LEU A  43
 None
None
None
NAP  A1001 (-3.4A)
None
 1.10A 5emlA-5ovlA:
2.4		 5emlA-5ovlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpu PUTATIVE
UNCHARACTERIZED
PROTEIN

(Campylobacter
jejuni) 		PF05523
(FdtA) 		5 LEU A  89
GLY A  65
ASN A  83
MET A  99
LEU A 108
 None
 1.32A 5emlA-5tpuA:
undetectable		 5emlA-5tpuA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucg STAGE II SPORULATION
PROTEIN E

(Bacillus
subtilis) 		PF07228
(SpoIIE) 		5 PRO A 774
GLY A 738
LEU A 735
ASN A 772
MET A 766
 None
 1.46A 5emlA-5ucgA:
undetectable		 5emlA-5ucgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE

(Brucella
melitensis) 		PF00551
(Formyl_trans_N) 		5 LEU A  25
LEU A 149
MET A  85
LEU A 176
CYH A  21
 None
 1.42A 5emlA-5vysA:
4.8		 5emlA-5vysA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 LEU A 260
GLY A 978
ASN A 982
ARG A 259
GLU A 268
 None
 1.38A 5emlA-5w81A:
undetectable		 5emlA-5w81A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE

(Toxoplasma
gondii) 		no annotation 5 GLY A 236
PRO A 238
MET A 122
GLU A 202
LEU A 204
 None
 1.26A 5emlA-5wrtA:
undetectable		 5emlA-5wrtA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wya ISOLEUCINE
2-EPIMERASE

(Lactobacillus
buchneri) 		PF00202
(Aminotran_3) 		5 PRO A 411
LEU A  50
GLY A 364
ASN A 366
LEU A 420
 None
 1.24A 5emlA-5wyaA:
2.2		 5emlA-5wyaA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8j THYMIDYLATE KINASE

(Thermus
thermophilus) 		no annotation 5 LEU A 122
GLY A  42
PRO A  45
LEU A  44
GLU A  71
 None
 1.46A 5emlA-5x8jA:
undetectable		 5emlA-5x8jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 PRO A 653
LEU A 628
LEU A 661
ASN A 651
LEU A 634
 None
 1.39A 5emlA-5zlnA:
undetectable		 5emlA-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 5 PRO B 152
LEU B 153
ASN B 145
ARG B  80
LEU B 183
 None
 1.24A 5emlA-6dftB:
2.6		 5emlA-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 PRO C1022
LEU C1024
GLY C 983
LEU C1020
CYH C1035
 None
 1.46A 5emlA-6en4C:
undetectable		 5emlA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 5 LEU A 248
LEU A 201
MET A 171
GLU A 240
CYH A 138
 None
 1.47A 5emlA-6fuyA:
undetectable		 5emlA-6fuyA:
undetectable