SIMILAR PATTERNS OF AMINO ACIDS FOR 5EML_A_SAMA701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 648
GLY A 644
ASN A 641
LEU A 671
CYH A 714
 None
 1.37A 5emlA-1dgjA:
undetectable		 5emlA-1dgjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		5 LEU A 186
GLY A 235
PRO A 275
LEU A 274
ARG A 182
 None
 1.21A 5emlA-1f2jA:
5.3		 5emlA-1f2jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gaj HIGH-AFFINITY
BRANCHED CHAIN AMINO
ACID TRANSPORT
ATP-BINDING PROTEIN

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		5 LEU A 115
GLY A 106
LEU A 103
ASN A 109
LEU A  94
 None
 1.28A 5emlA-1gajA:
undetectable		 5emlA-1gajA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 GLY A 403
PRO A 320
LEU A 407
ASN A 474
LEU A 420
 None
 1.39A 5emlA-1h79A:
2.6		 5emlA-1h79A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 273
GLY A 280
PRO A 228
LEU A 227
LEU A  29
 None
 1.31A 5emlA-1kvkA:
undetectable		 5emlA-1kvkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 PRO A 138
LEU A 137
GLY A 338
LEU A 318
LEU A 234
 None
 0.97A 5emlA-1kvkA:
undetectable		 5emlA-1kvkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ln4 HYPOTHETICAL PROTEIN
YHBY

(Escherichia
coli) 		PF01985
(CRS1_YhbY) 		5 LEU A   3
GLY A  13
PRO A  17
LEU A  18
CYH A  73
 None
 1.30A 5emlA-1ln4A:
2.8		 5emlA-1ln4A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 GLY A 349
PRO A 353
LEU A 354
LEU A 230
CYH A 260
 None
 1.44A 5emlA-1mb9A:
2.8		 5emlA-1mb9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		5 PRO A 376
LEU A 375
LEU A 381
LYS A 235
GLU A 213
 None
 1.35A 5emlA-1ndfA:
undetectable		 5emlA-1ndfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)

(Caenorhabditis
elegans) 		PF01633
(Choline_kinase) 		5 LEU A 159
GLY A  84
LEU A  89
ARG A 157
LEU A 262
 None
 1.39A 5emlA-1nw1A:
undetectable		 5emlA-1nw1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od5 GLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		5 PRO A 489
GLY A 378
LEU A 439
ASN A 345
GLU A 432
 None
 1.41A 5emlA-1od5A:
undetectable		 5emlA-1od5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A   8
GLY A  37
PRO A  77
LEU A  78
LEU A  10
 None
 1.27A 5emlA-1odoA:
undetectable		 5emlA-1odoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 GLY A 351
LEU A 307
ASN A 353
ARG A 361
LEU A 297
 None
 1.50A 5emlA-1qk1A:
undetectable		 5emlA-1qk1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica;
Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLY C  43
LEU C  59
ASN A 690
MET A 191
ARG C 136
 None
FES  C1908 ( 4.2A)
None
None
None
 1.28A 5emlA-1sb3C:
undetectable		 5emlA-1sb3C:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A

(Rattus
norvegicus) 		PF00625
(Guanylate_kin) 		5 PRO B 326
LEU B 329
GLY B 233
LEU B 387
ASN B 324
 None
 1.43A 5emlA-1t0hB:
undetectable		 5emlA-1t0hB:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU D 163
PRO D 146
LEU D 120
ASN D 169
LEU D 139
 None
 1.43A 5emlA-1u0nD:
undetectable		 5emlA-1u0nD:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 PRO D 164
LEU D 163
PRO D 146
LEU D 120
ASN D 169
 None
 1.16A 5emlA-1u0nD:
undetectable		 5emlA-1u0nD:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 LEU A 182
GLY A  48
LEU A  44
LYS A  51
ASN A  75
 PLP  A 413 (-4.5A)
None
None
PLP  A 413 (-1.3A)
PLP  A 413 (-3.9A)
 1.40A 5emlA-1ve5A:
2.7		 5emlA-1ve5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyv CALCIUM CHANNEL
BETA-4SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 PRO A 318
LEU A 321
GLY A 225
LEU A 378
ASN A 316
 None
 1.41A 5emlA-1vyvA:
undetectable		 5emlA-1vyvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		5 LEU A 357
GLY A 338
LEU A 287
ARG A 236
GLU A 335
 None
None
None
None
SRP  A 900 (-2.8A)
 1.17A 5emlA-1wleA:
undetectable		 5emlA-1wleA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		5 LEU A 183
GLY A  61
LEU A  57
ARG A 179
LEU A  28
 None
 1.23A 5emlA-2c2qA:
undetectable		 5emlA-2c2qA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 PRO A 496
GLY A 552
ASN A 501
ARG A 563
GLU A 558
 None
 1.08A 5emlA-2d3tA:
4.4		 5emlA-2d3tA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		5 GLY A 336
PRO A 316
LEU A 306
ASN A 145
LEU A 136
 None
 1.30A 5emlA-2dw6A:
2.9		 5emlA-2dw6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		5 GLY A 336
PRO A 316
LEU A 306
MET A 327
LEU A 136
 None
 1.41A 5emlA-2dw6A:
2.9		 5emlA-2dw6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2goy ADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01507
(PAPS_reduct) 		5 PRO A 230
GLY A  88
PRO A 114
LEU A 119
LEU A 128
 SF4  A 301 ( 4.6A)
None
None
None
None
 1.20A 5emlA-2goyA:
3.3		 5emlA-2goyA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 PRO A 495
LEU A 255
GLY A 220
MET A 268
LEU A 197
 None
 1.47A 5emlA-2i0kA:
undetectable		 5emlA-2i0kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		5 PRO A 234
LEU A 208
GLY A 168
GLU A 200
LEU A 206
 None
 1.39A 5emlA-2imrA:
5.6		 5emlA-2imrA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		5 LEU A 264
GLY A 163
LEU A 189
ASN A 232
LEU A 222
 None
 1.46A 5emlA-2oodA:
3.1		 5emlA-2oodA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or0 HYDROXYLASE

(Rhodococcus
jostii) 		PF08028
(Acyl-CoA_dh_2) 		5 PRO A  47
GLY A 101
ASN A 104
MET A 108
LEU A  88
 None
 1.00A 5emlA-2or0A:
undetectable		 5emlA-2or0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 PRO A 138
LEU A 137
GLY A 338
LEU A 318
LEU A 234
 None
 1.08A 5emlA-2r3vA:
undetectable		 5emlA-2r3vA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r44 UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF07726
(AAA_3) 		5 LEU A  71
PRO A  54
LEU A  50
ASN A  63
LEU A 151
 None
 1.30A 5emlA-2r44A:
undetectable		 5emlA-2r44A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF02390
(Methyltransf_4) 		5 GLY E 212
PRO E 281
LEU E 280
LYS E 177
LEU E 241
 None
 1.11A 5emlA-2vdvE:
4.0		 5emlA-2vdvE:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		5 LEU A  82
PRO A 167
LEU A 166
GLU A 146
CYH A 151
 None
 1.43A 5emlA-2w3pA:
undetectable		 5emlA-2w3pA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 PRO A  30
LEU A  44
PRO A 272
LEU A 256
ARG A 246
 None
None
FNR  A1330 (-4.5A)
None
None
 1.39A 5emlA-2ymvA:
undetectable		 5emlA-2ymvA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq1 ORF73

(Murid
gammaherpesvirus
4) 		no annotation 5 PRO A 140
LEU A 139
MET A 146
ARG A 147
CYH A 188
 None
 1.46A 5emlA-2yq1A:
undetectable		 5emlA-2yq1A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Homo sapiens) 		PF02732
(ERCC4) 		5 GLY B 265
LEU B 261
LYS B 430
LEU B 273
CYH B 437
 None
 1.27A 5emlA-2ziuB:
undetectable		 5emlA-2ziuB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 PRO A 346
LEU A 343
GLY A 167
LEU A 271
MET A 331
 None
 1.27A 5emlA-2zxhA:
undetectable		 5emlA-2zxhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE

(Bradyrhizobium
japonicum) 		PF00561
(Abhydrolase_1) 		5 LEU A 275
GLY A 184
LEU A 181
MET A 126
GLU A 284
 None
 1.43A 5emlA-3a2lA:
undetectable		 5emlA-3a2lA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE

(Bradyrhizobium
japonicum) 		PF00561
(Abhydrolase_1) 		5 LEU A 275
GLY A 184
PRO A 182
LEU A 181
GLU A 284
 None
 1.44A 5emlA-3a2lA:
undetectable		 5emlA-3a2lA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		5 PRO A 117
GLY A 174
LEU A 144
ASN A 171
GLU A 140
 None
None
None
0JO  A 401 (-3.6A)
None
 1.48A 5emlA-3b1eA:
undetectable		 5emlA-3b1eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 LEU A 152
LEU A 174
MET A 190
LEU A 179
CYH A 183
 None
 1.12A 5emlA-3b3dA:
4.0		 5emlA-3b3dA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjy PUTATIVE
THIOESTERASE

(Novosphingobium
aromaticivorans) 		PF13622
(4HBT_3) 		5 LEU A 239
PRO A 136
LEU A 135
LEU A 167
CYH A 219
 None
 1.38A 5emlA-3cjyA:
undetectable		 5emlA-3cjyA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 PRO A  99
LEU A  71
ASN A  77
LEU A  64
CYH A  56
 None
 1.27A 5emlA-3cvrA:
undetectable		 5emlA-3cvrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 LEU A  56
GLY A 130
PRO A 134
ASN A  63
ARG A 312
 None
 1.23A 5emlA-3djlA:
undetectable		 5emlA-3djlA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 LEU A 274
GLY A  18
LEU A  16
ARG A 250
LEU A 291
 None
 1.45A 5emlA-3dwiA:
3.4		 5emlA-3dwiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 GLY P   8
LEU P 104
ASN P  33
ARG P  28
LEU P  89
 FAD  P 449 (-3.3A)
None
None
None
None
 1.41A 5emlA-3fg2P:
3.5		 5emlA-3fg2P:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1

(Streptomyces
antibioticus) 		PF16670
(PI-PLC-C1) 		5 LEU A  58
MET A 111
GLU A  60
LEU A  61
CYH A 107
 None
 1.11A 5emlA-3h4xA:
2.0		 5emlA-3h4xA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn0 NITRATE TRANSPORT
PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 PRO A 112
LEU A 113
GLY A 161
LEU A 159
ARG A 165
 None
 1.36A 5emlA-3hn0A:
undetectable		 5emlA-3hn0A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsw EXCRETORY-SECRETORY
PROTEIN 2

(Ancylostoma
ceylanicum) 		no annotation 5 LEU A  67
GLY A  56
PRO A  53
ASN A  35
LEU A  75
 None
 1.35A 5emlA-3nswA:
undetectable		 5emlA-3nswA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 315
GLY A 264
ASN A 338
GLU A  96
LEU A  92
 None
None
None
EDO  A 413 (-4.7A)
EDO  A 413 ( 4.6A)
 1.41A 5emlA-3sf6A:
undetectable		 5emlA-3sf6A:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		6 GLY A 415
LYS A 451
ARG A 479
GLU A 499
LEU A 500
CYH A 513
 None
 1.00A 5emlA-3ua4A:
38.3		 5emlA-3ua4A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		6 GLY A 415
PRO A 419
LYS A 451
GLU A 499
LEU A 500
CYH A 513
 None
 1.35A 5emlA-3ua4A:
38.3		 5emlA-3ua4A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		8 GLY A 416
LYS A 451
ASN A 452
MET A 478
ARG A 479
GLU A 499
LEU A 500
CYH A 513
 None
 0.79A 5emlA-3ua4A:
38.3		 5emlA-3ua4A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		8 GLY A 416
PRO A 419
LYS A 451
ASN A 452
MET A 478
GLU A 499
LEU A 500
CYH A 513
 None
 0.78A 5emlA-3ua4A:
38.3		 5emlA-3ua4A:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 LEU A 404
GLY A 985
PRO A 988
LEU A 989
LEU A 400
 None
 1.03A 5emlA-3w9hA:
undetectable		 5emlA-3w9hA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 PRO A 104
GLY A 249
LEU A  75
ARG A 112
LEU A 100
 None
 1.40A 5emlA-3wafA:
2.1		 5emlA-3wafA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PRO A 650
LEU A 625
LEU A 658
ASN A 648
LEU A 631
 None
 1.49A 5emlA-3wpeA:
undetectable		 5emlA-3wpeA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 GLY A 420
LEU A 386
ASN A 440
ARG A 360
LEU A 372
 None
None
None
NAG  A1442 ( 4.7A)
None
 1.45A 5emlA-3zyiA:
undetectable		 5emlA-3zyiA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 GLY A 531
PRO A 517
LEU A 515
ASN A 529
ARG A 460
 None
 1.36A 5emlA-4d8mA:
undetectable		 5emlA-4d8mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		5 GLY A  31
LEU A  33
MET A  23
ARG A  27
LEU A  65
 None
 1.49A 5emlA-4emkA:
undetectable		 5emlA-4emkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 340
PRO A 495
LEU A 324
ASN A 333
LEU A 464
 None
 1.44A 5emlA-4fdhA:
undetectable		 5emlA-4fdhA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		11 PRO A 310
LEU A 311
GLY A 363
LEU A 367
LYS A 389
ASN A 390
MET A 416
ARG A 417
GLU A 431
LEU A 432
CYH A 445
 None
SAH  A 701 (-4.1A)
SAH  A 701 ( 4.1A)
None
SAH  A 701 (-4.0A)
None
SAH  A 701 (-4.3A)
SAH  A 701 ( 4.7A)
SAH  A 701 (-3.1A)
SAH  A 701 (-4.5A)
SAH  A 701 (-3.4A)
 0.47A 5emlA-4g56A:
48.6		 5emlA-4g56A:
80.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		11 PRO A 310
LEU A 311
GLY A 363
PRO A 366
LEU A 367
LYS A 389
ASN A 390
MET A 416
GLU A 431
LEU A 432
CYH A 445
 None
SAH  A 701 (-4.1A)
SAH  A 701 ( 4.1A)
None
None
SAH  A 701 (-4.0A)
None
SAH  A 701 (-4.3A)
SAH  A 701 (-3.1A)
SAH  A 701 (-4.5A)
SAH  A 701 (-3.4A)
 0.53A 5emlA-4g56A:
48.6		 5emlA-4g56A:
80.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		12 PRO A 314
LEU A 315
GLY A 367
PRO A 370
LEU A 371
LYS A 393
ASN A 394
MET A 420
ARG A 421
GLU A 435
LEU A 436
CYH A 449
 None
0XU  A 701 (-3.9A)
0XU  A 701 ( 3.7A)
0XU  A 701 (-4.2A)
0XU  A 701 (-4.3A)
0XU  A 701 (-3.9A)
None
0XU  A 701 (-4.4A)
0XU  A 701 ( 4.9A)
0XU  A 701 (-4.2A)
None
0XU  A 701 (-3.6A)
 0.36A 5emlA-4gqbA:
56.2		 5emlA-4gqbA:
98.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 LEU A 186
GLY A  44
LEU A  27
GLU A 190
CYH A 196
 None
None
GOL  A 603 ( 4.1A)
NAD  A 601 ( 2.9A)
None
 1.18A 5emlA-4i8pA:
3.8		 5emlA-4i8pA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 PRO A 106
LEU A  74
GLY A 352
LEU A 365
ASN A  72
 None
 1.31A 5emlA-4im4A:
8.1		 5emlA-4im4A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00884
(Sulfatase) 		5 PRO A 473
GLY A 458
LEU A 415
ASN A 460
GLU A 455
 None
 1.33A 5emlA-4kavA:
undetectable		 5emlA-4kavA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PRO A 357
LEU A 356
GLY A 337
LEU A 342
LEU A 370
 None
 1.43A 5emlA-4m7eA:
undetectable		 5emlA-4m7eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 PRO A  92
GLY A  86
MET A 131
GLU A 235
LEU A  90
 None
None
None
BDP  A 402 (-3.0A)
None
 1.30A 5emlA-4ovqA:
undetectable		 5emlA-4ovqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 PRO A 232
LEU A 207
LEU A 240
ASN A 230
LEU A 213
 None
 1.40A 5emlA-4qdhA:
undetectable		 5emlA-4qdhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		5 LEU A 171
GLY A  90
LEU A  96
ARG A 174
GLU A 155
 None
SAH  A1000 (-3.2A)
SAH  A1000 (-4.0A)
None
None
 1.40A 5emlA-4qppA:
25.6		 5emlA-4qppA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u06 LIC10831

(Leptospira
interrogans) 		PF12799
(LRR_4)
PF13855
(LRR_8) 		5 PRO A  85
LEU A  84
GLY A  66
LEU A  42
GLU A  64
 None
 1.36A 5emlA-4u06A:
undetectable		 5emlA-4u06A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		5 PRO A  46
LEU A  45
GLY A 288
ASN A 137
LEU A 107
 None
 1.48A 5emlA-4w7gA:
2.7		 5emlA-4w7gA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9u ACYL-COA
DEHYDROGENASE

(Brucella
abortus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 310
GLY A 259
ASN A 333
GLU A  88
LEU A  84
 None
 1.45A 5emlA-4w9uA:
undetectable		 5emlA-4w9uA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Sinorhizobium
meliloti) 		PF00496
(SBP_bac_5) 		5 LEU A 482
LEU A 275
ASN A 319
LEU A 449
CYH A 437
 None
 1.42A 5emlA-4wedA:
undetectable		 5emlA-4wedA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru PNKP1

(Capnocytophaga
gingivalis) 		PF13671
(AAA_33) 		5 GLY A 186
LEU A 184
ASN A 308
ARG A 297
CYH A 304
 MG  A 401 ( 4.7A)
None
None
None
None
 1.30A 5emlA-4xruA:
2.1		 5emlA-4xruA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		5 GLY A 433
PRO A  16
LEU A  66
ASN A 431
LEU A 436
 None
 1.47A 5emlA-4y0iA:
3.0		 5emlA-4y0iA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 219
PRO A 261
LEU A 236
ASN A 242
LEU A 225
 None
 1.21A 5emlA-4z64A:
undetectable		 5emlA-4z64A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zw2 VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1,VOLTAGE-DEPEN
DENT L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1

(Mus musculus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 PRO A 245
LEU A 248
GLY A 152
LEU A 305
ASN A 243
 None
 1.42A 5emlA-4zw2A:
undetectable		 5emlA-4zw2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 LEU A  78
GLY A 297
PRO A 278
LEU A 279
LEU A  37
 None
 1.49A 5emlA-5fyaA:
undetectable		 5emlA-5fyaA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASB

(Escherichia
coli) 		PF09485
(CRISPR_Cse2) 		5 PRO B 126
LEU B  87
GLY B  95
ASN B  93
LEU B 120
 None
 1.49A 5emlA-5h9fB:
undetectable		 5emlA-5h9fB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 PRO A 152
LEU A 151
GLY A 245
LEU A 101
CYH A  80
 None
 1.31A 5emlA-5hdjA:
undetectable		 5emlA-5hdjA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1

(Homo sapiens) 		PF01273
(LBP_BPI_CETP) 		5 PRO A  72
LEU A  73
GLY A 221
PRO A 225
LEU A 226
 None
 1.29A 5emlA-5i7kA:
undetectable		 5emlA-5i7kA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		5 LEU A  87
GLY A 101
ASN A 100
LEU A 121
CYH A 211
 None
 1.30A 5emlA-5ipxA:
undetectable		 5emlA-5ipxA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1

(Mus musculus) 		PF01825
(GPS) 		5 LEU A 298
GLY A 314
LEU A 289
GLU A 213
LEU A 212
 None
 1.31A 5emlA-5kvmA:
undetectable		 5emlA-5kvmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzy SMOOTHENED

(Xenopus laevis) 		PF01392
(Fz) 		5 GLY A 135
PRO A 137
LEU A 140
ARG A  90
LEU A  85
 None
CY8  A1201 ( 4.9A)
None
None
CY8  A1201 (-4.1A)
 1.47A 5emlA-5kzyA:
undetectable		 5emlA-5kzyA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 LEU A 646
PRO A 577
LEU A 576
MET A 625
GLU A 588
 None
 1.32A 5emlA-5lq3A:
undetectable		 5emlA-5lq3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mau CHLORITE DISMUTASE

(Cyanothece sp.
PCC 7425) 		no annotation 5 GLY A   9
LEU A  28
ASN A  35
ARG A 128
LEU A  87
 None
None
None
GOL  A 204 (-3.7A)
None
 1.38A 5emlA-5mauA:
undetectable		 5emlA-5mauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovl 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A  31
PRO A  60
LEU A  63
ASN A  96
LEU A  43
 None
None
None
NAP  A1001 (-3.4A)
None
 1.10A 5emlA-5ovlA:
2.4		 5emlA-5ovlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpu PUTATIVE
UNCHARACTERIZED
PROTEIN

(Campylobacter
jejuni) 		PF05523
(FdtA) 		5 LEU A  89
GLY A  65
ASN A  83
MET A  99
LEU A 108
 None
 1.32A 5emlA-5tpuA:
undetectable		 5emlA-5tpuA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucg STAGE II SPORULATION
PROTEIN E

(Bacillus
subtilis) 		PF07228
(SpoIIE) 		5 PRO A 774
GLY A 738
LEU A 735
ASN A 772
MET A 766
 None
 1.46A 5emlA-5ucgA:
undetectable		 5emlA-5ucgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE

(Brucella
melitensis) 		PF00551
(Formyl_trans_N) 		5 LEU A  25
LEU A 149
MET A  85
LEU A 176
CYH A  21
 None
 1.42A 5emlA-5vysA:
4.8		 5emlA-5vysA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 LEU A 260
GLY A 978
ASN A 982
ARG A 259
GLU A 268
 None
 1.38A 5emlA-5w81A:
undetectable		 5emlA-5w81A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE

(Toxoplasma
gondii) 		no annotation 5 GLY A 236
PRO A 238
MET A 122
GLU A 202
LEU A 204
 None
 1.26A 5emlA-5wrtA:
undetectable		 5emlA-5wrtA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wya ISOLEUCINE
2-EPIMERASE

(Lactobacillus
buchneri) 		PF00202
(Aminotran_3) 		5 PRO A 411
LEU A  50
GLY A 364
ASN A 366
LEU A 420
 None
 1.24A 5emlA-5wyaA:
2.2		 5emlA-5wyaA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8j THYMIDYLATE KINASE

(Thermus
thermophilus) 		no annotation 5 LEU A 122
GLY A  42
PRO A  45
LEU A  44
GLU A  71
 None
 1.46A 5emlA-5x8jA:
undetectable		 5emlA-5x8jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 PRO A 653
LEU A 628
LEU A 661
ASN A 651
LEU A 634
 None
 1.39A 5emlA-5zlnA:
undetectable		 5emlA-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 5 PRO B 152
LEU B 153
ASN B 145
ARG B  80
LEU B 183
 None
 1.24A 5emlA-6dftB:
2.6		 5emlA-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 PRO C1022
LEU C1024
GLY C 983
LEU C1020
CYH C1035
 None
 1.46A 5emlA-6en4C:
undetectable		 5emlA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 5 LEU A 248
LEU A 201
MET A 171
GLU A 240
CYH A 138
 None
 1.47A 5emlA-6fuyA:
undetectable		 5emlA-6fuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckm MRNA CAPPING ENZYME

(Paramecium
bursaria
Chlorella virus
1) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 TYR A 111
GLY A  85
GLU A 131
ASP A 213
 None
None
GTP  A 899 (-3.0A)
None
 1.23A 5emlA-1ckmA:
undetectable		 5emlA-1ckmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN

(Thermococcus
litoralis) 		PF01547
(SBP_bac_1) 		4 TYR A 187
GLY A 179
GLU A 239
ASP A  45
 None
TRE  A 563 (-3.5A)
TRE  A 563 (-2.9A)
None
 1.00A 5emlA-1eu8A:
undetectable		 5emlA-1eu8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		4 TYR A 211
TYR A 324
GLY A 262
ASP A 267
 LAF  A1336 ( 3.9A)
LAF  A1337 (-4.6A)
None
None
 1.34A 5emlA-1gzgA:
6.0		 5emlA-1gzgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7p NADH-CYTOCHROME B5
REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 TYR A 112
TYR A  93
GLY A 180
ASP A 239
 FAD  A 301 (-4.2A)
FAD  A 301 (-4.3A)
None
None
 1.28A 5emlA-1i7pA:
3.2		 5emlA-1i7pA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 TYR A  62
TYR A 127
GLY A  79
GLU A  77
 None
 1.12A 5emlA-1pgsA:
undetectable		 5emlA-1pgsA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		4 TYR A 345
TYR A 331
GLY A 379
GLU A 380
 None
 1.29A 5emlA-1q15A:
4.3		 5emlA-1q15A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		4 TYR A 171
GLY A 190
GLU A 213
ASP A 240
 ACT  A 421 ( 4.2A)
SAM  A 635 (-3.8A)
SAM  A 635 (-2.9A)
SAM  A 635 (-3.7A)
 0.96A 5emlA-1qzzA:
8.8		 5emlA-1qzzA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 TYR A 316
GLY A 163
GLU A 199
ASP A 197
 None
TYM  A 501 (-3.6A)
TYM  A 501 (-3.0A)
None
 1.21A 5emlA-1r6uA:
undetectable		 5emlA-1r6uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LYS A 204
TYR A 205
GLY A 161
GLU A 160
 None
None
None
TPP  A1671 (-3.9A)
 0.95A 5emlA-1r9jA:
undetectable		 5emlA-1r9jA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 TYR A  74
TYR A 155
GLY A 341
ASP A 308
 None
 1.25A 5emlA-1up4A:
undetectable		 5emlA-1up4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		4 TYR A 105
TYR A 171
GLY A 102
GLU A 103
 None
 1.26A 5emlA-1xfuA:
undetectable		 5emlA-1xfuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		4 TYR A 358
GLY A 362
GLU A 170
ASP A  21
 None
 1.28A 5emlA-1zmrA:
undetectable		 5emlA-1zmrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ba0 ARCHAEAL EXOSOME RNA
BINDING PROTEIN RRP4

(Archaeoglobus
fulgidus) 		PF00575
(S1)
PF14382
(ECR1_N)
PF15985
(KH_6) 		4 TYR A  53
TYR A  20
GLY A  58
ASP A 128
 None
 1.04A 5emlA-2ba0A:
undetectable		 5emlA-2ba0A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		4 TYR A 279
GLY A 307
GLU A 308
ASP A 173
 None
 1.29A 5emlA-2c0hA:
7.0		 5emlA-2c0hA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A 305
GLY A 258
GLU A  76
ASP A 265
 None
 1.33A 5emlA-2cx9A:
undetectable		 5emlA-2cx9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 TYR A 477
TYR A 447
GLY A 470
GLU A 473
 None
 1.34A 5emlA-2fj0A:
undetectable		 5emlA-2fj0A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR N 456
GLY I 461
GLU I 462
ASP I 207
 None
None
NGT  A  21 (-3.0A)
NGT  A  21 (-3.8A)
 1.00A 5emlA-2gk1N:
4.0		 5emlA-2gk1N:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		no annotation
no annotation
no annotation 		4 TYR I 427
GLY N 490
GLU N 491
ASP M 240
 None
 1.17A 5emlA-2gk1I:
4.0		 5emlA-2gk1I:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 TYR A 141
TYR A 211
GLY A 201
ASP A  19
 None
 1.20A 5emlA-2gksA:
2.8		 5emlA-2gksA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 LYS 1 244
TYR 1 245
GLY 1 472
ASP 1 294
 None
 1.15A 5emlA-2ijd1:
undetectable		 5emlA-2ijd1:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh1 MICRONEMAL PROTEIN 1

(Toxoplasma
gondii) 		PF10564
(MAR_sialic_bdg) 		4 TYR A 203
TYR A 137
GLY A 144
GLU A 165
 None
None
ACT  A1257 ( 3.9A)
None
 0.90A 5emlA-2jh1A:
undetectable		 5emlA-2jh1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A 351
GLY A 303
GLU A 126
ASP A 310
 None
 1.33A 5emlA-2jifA:
undetectable		 5emlA-2jifA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TYR A 463
TYR A  40
GLY A 370
ASP A 338
 None
 1.34A 5emlA-2pwhA:
5.7		 5emlA-2pwhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		4 TYR A 410
GLY A 376
GLU A 404
ASP A 283
 None
 1.20A 5emlA-2v5iA:
undetectable		 5emlA-2v5iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 TYR A  51
GLY A 112
GLU A 114
ASP A 104
 None
 1.04A 5emlA-2vn8A:
6.5		 5emlA-2vn8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 TYR A 614
GLY A 519
GLU A 518
ASP A 498
 None
 1.30A 5emlA-2wanA:
4.0		 5emlA-2wanA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		4 TYR A 304
TYR A 296
GLY A 307
GLU A 306
 None
 1.14A 5emlA-2x1cA:
undetectable		 5emlA-2x1cA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		4 TYR A 254
LYS B 338
TYR B 339
GLY A 263
 None
 1.24A 5emlA-2xsjA:
undetectable		 5emlA-2xsjA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 TYR A 293
TYR A 347
GLY A 367
GLU A 389
 None
None
None
CA  A 621 (-2.5A)
 1.26A 5emlA-2zuyA:
undetectable		 5emlA-2zuyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 TYR A 177
GLY A 198
GLU A 220
ASP A 255
 SPM  A 501 (-4.2A)
MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
 1.30A 5emlA-3c6mA:
3.4		 5emlA-3c6mA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co8 ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 TYR A 208
GLY A 234
GLU A 230
ASP A 240
 None
 1.00A 5emlA-3co8A:
6.6		 5emlA-3co8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Staphylococcus
aureus) 		PF13460
(NAD_binding_10) 		4 TYR A 171
TYR A 106
GLY A 250
ASP A 166
 None
 1.32A 5emlA-3e48A:
2.4		 5emlA-3e48A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpn GEOBACILLUS
STEAROTHERMOPHILUS
UVRA INTERACTION
DOMAIN
GEOBACILLUS
STEAROTHERMOPHILUS
UVRB INTERACTION
DOMAIN

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		no annotation
no annotation 		4 LYS A 226
GLY A 173
GLU B 201
ASP B 228
 None
 1.25A 5emlA-3fpnA:
undetectable		 5emlA-3fpnA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		4 TYR A  34
GLY A  53
GLU A  74
ASP A  97
 None
 1.08A 5emlA-3hnrA:
5.6		 5emlA-3hnrA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		4 TYR A 426
TYR A 272
GLU A 162
ASP A 159
 None
 1.17A 5emlA-3hq2A:
undetectable		 5emlA-3hq2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LYS A 156
TYR A 158
GLY A 127
ASP A 288
 None
 1.31A 5emlA-3ip3A:
2.3		 5emlA-3ip3A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju5 ARGININE KINASE

(Apostichopus
japonicus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 TYR A  87
TYR A  73
GLY A  64
ASP A  60
 None
 1.13A 5emlA-3ju5A:
undetectable		 5emlA-3ju5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		4 LYS A 169
TYR A 170
GLY A 260
GLU A 263
 None
 1.30A 5emlA-3jujA:
undetectable		 5emlA-3jujA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN

(Klebsiella
pneumoniae) 		PF00149
(Metallophos) 		4 TYR A 122
GLY A 100
GLU A 103
ASP A  16
 None
None
None
MN  A 340 (-3.2A)
 1.32A 5emlA-3jyfA:
undetectable		 5emlA-3jyfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 LYS A 315
TYR A 323
GLY A 302
ASP A 211
 None
 1.22A 5emlA-3ll7A:
6.6		 5emlA-3ll7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 TYR A 242
GLY A 585
GLU A 588
ASP A 698
 None
 1.27A 5emlA-3lppA:
4.3		 5emlA-3lppA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngx BIFUNCTIONAL PROTEIN
FOLD

(Thermoplasma
acidophilum) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A  44
TYR A 225
GLY A 254
ASP A 141
 None
 1.22A 5emlA-3ngxA:
2.3		 5emlA-3ngxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61

(Homo sapiens) 		PF00400
(WD40) 		4 TYR A 301
TYR A 282
GLY A 279
ASP A 294
 None
None
UNX  A 307 ( 3.9A)
UNX  A1001 ( 3.5A)
 1.27A 5emlA-3ow8A:
undetectable		 5emlA-3ow8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 TYR A  28
GLY A  66
GLU A 101
ASP A 156
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
 0.96A 5emlA-3ps9A:
6.1		 5emlA-3ps9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
NUCLEOTIDE EXCHANGE
FACTOR SIL1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00012
(HSP70)
PF16782
(SIL1) 		4 LYS C 166
TYR C 165
GLY A 384
ASP A 244
 None
 1.25A 5emlA-3qmlC:
undetectable		 5emlA-3qmlC:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TYR A  65
TYR A  28
GLY A  68
GLU A  51
 None
 1.17A 5emlA-3qwbA:
5.5		 5emlA-3qwbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00160
(Pro_isomerase) 		4 TYR A 109
TYR A 399
GLU A 126
ASP A 130
 None
 1.30A 5emlA-3rfyA:
undetectable		 5emlA-3rfyA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 TYR A 386
GLY A 414
GLU A 450
ASP A 477
 None
 0.60A 5emlA-3ua4A:
38.3		 5emlA-3ua4A:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300

(Pyrococcus
horikoshii) 		PF01171
(ATP_bind_3) 		4 TYR A  16
LYS A  33
TYR A  29
GLU A 239
 None
 1.28A 5emlA-3vrhA:
undetectable		 5emlA-3vrhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		4 TYR A 264
GLY A 292
GLU A 293
ASP A 158
 TRS  A 401 ( 4.8A)
None
TRS  A 401 (-2.7A)
None
 1.31A 5emlA-3vupA:
3.7		 5emlA-3vupA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE

(Caldanaerobius
polysaccharolyticus) 		PF00150
(Cellulase) 		4 TYR A 198
TYR A 241
GLY A 178
GLU A 137
 TRS  A 401 ( 4.9A)
None
None
TRS  A 401 (-2.7A)
 1.26A 5emlA-3w0kA:
3.9		 5emlA-3w0kA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LYS B1755
TYR B1751
GLY B1631
ASP B1628
 None
 1.33A 5emlA-3zefB:
2.6		 5emlA-3zefB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 204
GLY A 442
GLU A 441
ASP A 370
 None
 1.33A 5emlA-3zz1A:
4.1		 5emlA-3zz1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 TYR A  89
TYR A  75
GLY A  66
ASP A  62
 None
None
ARG  A 400 (-3.8A)
None
 1.16A 5emlA-4bhlA:
undetectable		 5emlA-4bhlA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		4 TYR A 672
TYR A 130
GLY A 709
ASP A 746
 GAL  A1795 ( 4.2A)
None
None
GOL  A1798 (-3.8A)
 1.09A 5emlA-4bq4A:
2.7		 5emlA-4bq4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY

(Staphylococcus
aureus) 		PF00877
(NLPC_P60)
PF13702
(Lysozyme_like) 		4 TYR A 197
TYR A 176
GLU A  83
ASP A  90
 None
 1.29A 5emlA-4fdyA:
undetectable		 5emlA-4fdyA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 TYR A 317
GLY A 299
GLU A 300
ASP A 343
 None
 1.27A 5emlA-4fixA:
undetectable		 5emlA-4fixA:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 TYR A 320
GLY A 361
GLU A 388
ASP A 415
 SAH  A 701 (-4.3A)
SAH  A 701 (-3.3A)
SAH  A 701 (-2.5A)
SAH  A 701 (-2.8A)
 0.48A 5emlA-4g56A:
48.4		 5emlA-4g56A:
80.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl6 HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		PF16440
(DUF5037) 		4 TYR A  98
TYR A  36
GLY A  42
GLU A  43
 None
 1.17A 5emlA-4gl6A:
undetectable		 5emlA-4gl6A:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		6 TYR A 324
LYS A 333
TYR A 334
GLY A 365
GLU A 392
ASP A 419
 0XU  A 701 (-4.3A)
0XU  A 701 (-3.0A)
0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.17A 5emlA-4gqbA:
56.2		 5emlA-4gqbA:
98.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7

(Clostridioides
difficile) 		PF00877
(NLPC_P60)
PF13702
(Lysozyme_like) 		4 TYR A 196
TYR A 175
GLU A  81
ASP A  88
 GOL  A 406 ( 4.5A)
None
GOL  A 406 (-2.9A)
None
 1.28A 5emlA-4hpeA:
undetectable		 5emlA-4hpeA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 248
GLY A 510
GLU A 509
ASP A 437
 BGC  A 943 ( 4.5A)
None
BGC  A 942 (-3.1A)
BGC  A 943 ( 4.8A)
 1.33A 5emlA-4iigA:
3.9		 5emlA-4iigA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 TYR A  73
TYR A  49
GLY A  53
ASP A 184
 None
 1.28A 5emlA-4jypA:
2.1		 5emlA-4jypA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		4 TYR A 216
TYR A  60
GLY A 133
ASP A 160
 None
 1.25A 5emlA-4k3fA:
undetectable		 5emlA-4k3fA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 TYR A 348
TYR A 300
GLY A 378
GLU A 437
 None
 1.32A 5emlA-4maeA:
undetectable		 5emlA-4maeA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 TYR A 249
TYR A  86
GLY A 254
GLU A 324
 None
 1.16A 5emlA-4mguA:
undetectable		 5emlA-4mguA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 LYS A 420
GLY A 479
GLU A 481
ASP A 812
 None
 1.31A 5emlA-4n3sA:
2.2		 5emlA-4n3sA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		4 TYR A 592
TYR A 636
GLY A 504
ASP A 403
 None
 1.32A 5emlA-4nj5A:
undetectable		 5emlA-4nj5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pux UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF11578
(DUF3237) 		4 LYS A 150
TYR A 151
GLY A  68
GLU A  67
 None
 1.14A 5emlA-4puxA:
undetectable		 5emlA-4puxA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified) 		PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3) 		4 TYR A 137
GLY A  41
GLU A  51
ASP A  49
 None
F  A 302 ( 4.2A)
None
None
 1.26A 5emlA-4q3kA:
2.3		 5emlA-4q3kA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 TYR A 232
GLY A  12
GLU A  44
ASP A  37
 None
CL  A 402 ( 4.1A)
None
None
 1.33A 5emlA-4q3nA:
undetectable		 5emlA-4q3nA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 TYR A 549
GLY A 604
GLU A 603
ASP A 535
 None
 1.34A 5emlA-4qi4A:
undetectable		 5emlA-4qi4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 TYR A 549
GLY A 604
GLU A 603
ASP A 535
 None
 1.27A 5emlA-4qi6A:
undetectable		 5emlA-4qi6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 TYR A  93
TYR A  79
GLY A  70
ASP A  66
 None
None
ARG  A 805 (-3.8A)
None
 1.13A 5emlA-4rf7A:
undetectable		 5emlA-4rf7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT V,
CHLOROPLASTIC

(Pisum sativum;
Pisum sativum) 		PF00223
(PsaA_PsaB)
PF01241
(PSI_PSAK) 		4 TYR B 323
GLY G  98
GLU G  93
ASP G 102
 CLA  B1221 (-4.0A)
None
None
None
 1.24A 5emlA-4rkuB:
undetectable		 5emlA-4rkuB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl4 GTP CYCLOHYDROLASE-2

(Helicobacter
pylori) 		PF00925
(GTP_cyclohydro2) 		4 LYS A 154
TYR A 130
GLY A  93
GLU A  92
 PPV  A 201 (-2.8A)
None
None
None
 1.35A 5emlA-4rl4A:
undetectable		 5emlA-4rl4A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		4 TYR A  68
TYR A  86
GLY A 105
ASP A 249
 None
 1.31A 5emlA-4y7dA:
undetectable		 5emlA-4y7dA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		4 TYR A 368
GLY A 372
GLU A 170
ASP A  21
 None
 1.15A 5emlA-5bt8A:
3.9		 5emlA-5bt8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 TYR B 462
TYR B  40
GLY B 370
ASP B 339
 None
 1.34A 5emlA-5do8B:
3.7		 5emlA-5do8B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN

(Yersinia pestis) 		PF00149
(Metallophos) 		4 TYR A 145
GLY A 123
GLU A 126
ASP A  39
 None
None
None
FE  A 402 (-3.1A)
 1.32A 5emlA-5eqvA:
undetectable		 5emlA-5eqvA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 TYR A 253
GLY A  58
GLU A  57
ASP A 494
 None
 1.32A 5emlA-5ev7A:
undetectable		 5emlA-5ev7A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		4 TYR A  23
GLY A  38
GLU A  39
ASP A  83
 None
 1.34A 5emlA-5fa1A:
2.3		 5emlA-5fa1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 249
GLY A 511
GLU A 510
ASP A 438
 None
None
EDO  A1872 ( 4.9A)
EDO  A1872 ( 4.8A)
 1.27A 5emlA-5fjiA:
2.5		 5emlA-5fjiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 249
GLY A 511
GLU A 510
ASP A 438
 None
None
None
PEG  A6002 ( 4.4A)
 1.32A 5emlA-5fjjA:
3.0		 5emlA-5fjjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzs GGDEF FAMILY PROTEIN

(Vibrio cholerae) 		PF00497
(SBP_bac_3) 		4 TYR A 281
TYR A 353
GLU A 276
ASP A 324
 None
 1.28A 5emlA-5gzsA:
2.1		 5emlA-5gzsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 245
GLY A 506
GLU A 505
ASP A 433
 BGC  A 946 (-4.7A)
None
BGC  A 946 (-3.3A)
None
 1.33A 5emlA-5ju6A:
2.7		 5emlA-5ju6A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII) 		4 TYR C 395
GLY C 102
GLU C 300
ASP C 187
 None
 1.33A 5emlA-5mdxC:
undetectable		 5emlA-5mdxC:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz8 ALDEHYDE
DEHYDROGENASE 21

(Physcomitrella
patens) 		PF00171
(Aldedh) 		4 TYR A 296
TYR A 340
GLY A 117
ASP A 124
 SIN  A 501 (-4.7A)
None
None
None
 1.10A 5emlA-5mz8A:
3.2		 5emlA-5mz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 TYR A 244
GLY A 506
GLU A 505
ASP A 432
 None
 1.25A 5emlA-5nbsA:
3.0		 5emlA-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L24,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		PF00467
(KOW)
PF17136
(ribosomal_L24)
PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 LYS d 207
TYR d 209
GLY V  90
GLU V 112
 None
 1.15A 5emlA-5oold:
undetectable		 5emlA-5oold:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3

(Saccharomyces
cerevisiae) 		PF08238
(Sel1) 		4 TYR A 507
GLY A 594
GLU A 552
ASP A 597
 None
 0.73A 5emlA-5v7vA:
undetectable		 5emlA-5v7vA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 4 TYR A 179
GLY A  97
GLU A 135
ASP A 106
 None
 1.31A 5emlA-5vqdA:
5.8		 5emlA-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 TYR A 365
GLY A 269
GLU A 268
ASP A 246
 None
None
CA  A 717 (-2.7A)
None
 1.34A 5emlA-5ww1A:
4.9		 5emlA-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 TYR A 248
TYR A 231
GLY A 149
GLU A 144
 None
EDO  A1801 (-3.2A)
None
None
 1.08A 5emlA-5x7sA:
3.1		 5emlA-5x7sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN

(Shewanella
loihica) 		no annotation 4 TYR A  59
LYS A 307
GLY A  82
ASP A 161
 None
 1.16A 5emlA-5x8zA:
undetectable		 5emlA-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 4 TYR A 181
GLY A 208
GLU A 229
ASP A 295
 None
SAM  A 505 (-3.3A)
SAM  A 505 (-2.9A)
SAM  A 505 (-3.6A)
 0.84A 5emlA-5yf0A:
8.8		 5emlA-5yf0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 4 TYR A 214
TYR A 201
GLY A 308
ASP A 124
 None
 1.35A 5emlA-6b82A:
undetectable		 5emlA-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 4 TYR A 385
TYR A 429
GLY A 444
ASP A 290
 None
 1.35A 5emlA-6bbpA:
2.0		 5emlA-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d1q RNA
PYROPHOSPHOHYDROLASE

(Escherichia
coli) 		no annotation 4 LYS B 140
TYR B 144
GLY B  38
GLU B  53
 None
 1.25A 5emlA-6d1qB:
undetectable		 5emlA-6d1qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC

(Acetobacterium
woodii) 		no annotation 4 TYR C 299
GLY C 251
GLU C  73
ASP C 258
 None
 1.35A 5emlA-6fahC:
undetectable		 5emlA-6fahC:
undetectable