SIMILAR PATTERNS OF AMINO ACIDS FOR 5EF3_L_TRPL101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 SER A 643
HIS A 147
HIS A 167
THR A 168
 FLC  A 756 (-2.8A)
None
O  A1100 ( 3.9A)
None
 0.84A 5ef3L-1b0kA:
0.0
5ef3V-1b0kA:
0.0		 5ef3L-1b0kA:
8.16
5ef3V-1b0kA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 THR A  82
GLY A 118
ALA A  25
THR A 125
 None
 0.68A 5ef3L-1c3xA:
undetectable
5ef3V-1c3xA:
undetectable		 5ef3L-1c3xA:
14.98
5ef3V-1c3xA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 THR A  81
SER A 276
GLY A 307
ALA A 113
 None
 0.93A 5ef3L-1eblA:
undetectable
5ef3V-1eblA:
undetectable		 5ef3L-1eblA:
13.36
5ef3V-1eblA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 GLY A 344
ALA A 318
HIS A 283
THR A 284
 None
 0.67A 5ef3L-1f26A:
undetectable
5ef3V-1f26A:
undetectable		 5ef3L-1f26A:
11.72
5ef3V-1f26A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		4 SER A 153
GLY A 137
HIS A 136
THR A 134
 None
 0.91A 5ef3L-1gzgA:
undetectable
5ef3V-1gzgA:
0.0		 5ef3L-1gzgA:
14.07
5ef3V-1gzgA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 SER A  57
ALA A  60
HIS A  34
THR A  35
 None
 0.86A 5ef3L-1i9gA:
1.2
5ef3V-1i9gA:
1.3		 5ef3L-1i9gA:
15.33
5ef3V-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 GLY A  46
HIS A  38
ALA A  51
THR A 299
 None
 0.87A 5ef3L-1iduA:
undetectable
5ef3V-1iduA:
undetectable		 5ef3L-1iduA:
8.08
5ef3V-1iduA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PO4  A 655 (-3.6A)
None
None
 0.77A 5ef3L-1lw3A:
undetectable
5ef3V-1lw3A:
undetectable		 5ef3L-1lw3A:
7.46
5ef3V-1lw3A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 THR A 389
SER A 384
GLY A  11
THR A 156
 None
 0.81A 5ef3L-1mb9A:
undetectable
5ef3V-1mb9A:
undetectable		 5ef3L-1mb9A:
9.16
5ef3V-1mb9A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		4 THR A 170
GLY A  66
ALA A 134
HIS A 105
 None
 0.90A 5ef3L-1mf1A:
undetectable
5ef3V-1mf1A:
undetectable		 5ef3L-1mf1A:
12.81
5ef3V-1mf1A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 GLY B 156
ALA B 151
THR B 139
THR B 137
 None
 0.95A 5ef3L-1mioB:
undetectable
5ef3V-1mioB:
undetectable		 5ef3L-1mioB:
9.76
5ef3V-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 GLY B 156
THR B 139
HIS B 103
THR B 137
 None
 0.69A 5ef3L-1mioB:
undetectable
5ef3V-1mioB:
undetectable		 5ef3L-1mioB:
9.76
5ef3V-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npc NEUTRAL PROTEASE

(Bacillus cereus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 150
SER A 170
GLY A 163
ALA A 168
 None
ZN  A 323 ( 4.7A)
None
None
 0.91A 5ef3L-1npcA:
undetectable
5ef3V-1npcA:
undetectable		 5ef3L-1npcA:
12.93
5ef3V-1npcA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 THR Q 376
GLY Q 105
ALA Q  96
THR Q  99
 None
 0.75A 5ef3L-1oh2Q:
undetectable
5ef3V-1oh2Q:
undetectable		 5ef3L-1oh2Q:
12.04
5ef3V-1oh2Q:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus;
Bean pod mottle
virus) 		PF02248
(Como_SCP)
PF02247
(Como_LCP) 		4 SER 2 101
GLY 2 222
ALA 1 180
THR 2 106
 None
 0.98A 5ef3L-1pgw2:
2.0
5ef3V-1pgw2:
undetectable		 5ef3L-1pgw2:
11.68
5ef3V-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 THR A  52
GLY A  61
ALA A  84
HIS A  55
 None
 0.85A 5ef3L-1qh5A:
undetectable
5ef3V-1qh5A:
undetectable		 5ef3L-1qh5A:
14.90
5ef3V-1qh5A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 SER A 179
GLY A 174
ALA A 320
THR A 181
 None
 0.95A 5ef3L-1szpA:
undetectable
5ef3V-1szpA:
undetectable		 5ef3L-1szpA:
13.00
5ef3V-1szpA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 THR A  32
THR A 313
HIS A 315
THR A 317
 None
 0.94A 5ef3L-1uzgA:
undetectable
5ef3V-1uzgA:
undetectable		 5ef3L-1uzgA:
11.48
5ef3V-1uzgA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 GLY A 138
ALA A 143
THR A  30
HIS A  15
 None
 0.95A 5ef3L-1vz8A:
undetectable
5ef3V-1vz8A:
undetectable		 5ef3L-1vz8A:
11.70
5ef3V-1vz8A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.71A 5ef3L-1zsqA:
undetectable
5ef3V-1zsqA:
undetectable		 5ef3L-1zsqA:
12.02
5ef3V-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 SER A 779
HIS A 178
HIS A 207
THR A 208
 None
SF4  A1000 (-4.5A)
SF4  A1000 (-4.1A)
None
 0.94A 5ef3L-2b3xA:
undetectable
5ef3V-2b3xA:
undetectable		 5ef3L-2b3xA:
6.19
5ef3V-2b3xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 319
GLY A 182
ALA A 208
THR A 185
 None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
 0.79A 5ef3L-2eerA:
undetectable
5ef3V-2eerA:
undetectable		 5ef3L-2eerA:
13.02
5ef3V-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 GLY B 677
ALA B 688
THR B 417
HIS B 682
 None
None
None
NI  B 901 (-2.8A)
 0.88A 5ef3L-2fffB:
undetectable
5ef3V-2fffB:
undetectable		 5ef3L-2fffB:
11.03
5ef3V-2fffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A  40
SER A  60
GLY A 145
THR A 175
 None
None
LDA  A 803 (-4.2A)
None
 0.98A 5ef3L-2gskA:
undetectable
5ef3V-2gskA:
undetectable		 5ef3L-2gskA:
7.94
5ef3V-2gskA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Arabidopsis
thaliana) 		PF01704
(UDPGP) 		4 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5ef3L-2icyA:
undetectable
5ef3V-2icyA:
undetectable		 5ef3L-2icyA:
12.69
5ef3V-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 THR C  96
GLY C  90
ALA C 262
HIS C  63
 None
 0.95A 5ef3L-2nymC:
undetectable
5ef3V-2nymC:
undetectable		 5ef3L-2nymC:
13.83
5ef3V-2nymC:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox1 3-DEHYDROQUINATE
DEHYDRATASE

(Archaeoglobus
fulgidus) 		PF01487
(DHquinase_I) 		4 THR A 158
GLY A 152
ALA A 124
THR A 103
 None
None
GOL  A 201 ( 4.8A)
None
 0.96A 5ef3L-2ox1A:
undetectable
5ef3V-2ox1A:
undetectable		 5ef3L-2ox1A:
15.54
5ef3V-2ox1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 SER A 198
GLY A 276
THR A 107
HIS A 134
 None
 0.87A 5ef3L-2qfvA:
0.0
5ef3V-2qfvA:
undetectable		 5ef3L-2qfvA:
11.53
5ef3V-2qfvA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		4 THR A 141
GLY A 366
ALA A 393
THR A 370
 None
TRS  A1478 ( 3.5A)
None
None
 0.98A 5ef3L-2vg8A:
undetectable
5ef3V-2vg8A:
undetectable		 5ef3L-2vg8A:
9.51
5ef3V-2vg8A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 THR A  24
GLY A  43
ALA A 190
THR A  18
 None
 0.90A 5ef3L-2z0mA:
undetectable
5ef3V-2z0mA:
undetectable		 5ef3L-2z0mA:
13.55
5ef3V-2z0mA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2x TK-SUBTILISIN

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 SER A 271
GLY A 283
ALA A 274
THR A 323
 None
None
None
MIS  A 324 ( 3.9A)
 0.98A 5ef3L-2z2xA:
undetectable
5ef3V-2z2xA:
undetectable		 5ef3L-2z2xA:
14.34
5ef3V-2z2xA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 THR A 112
SER A  74
GLY A 166
THR A 178
THR A 179
 NAD  A3001 ( 4.5A)
None
NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
 1.34A 5ef3L-3a1nA:
undetectable
5ef3V-3a1nA:
undetectable		 5ef3L-3a1nA:
13.02
5ef3V-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 270
SER A 301
ALA A 299
HIS A 295
 None
None
None
GOL  A 372 (-4.7A)
 0.95A 5ef3L-3cyjA:
undetectable
5ef3V-3cyjA:
undetectable		 5ef3L-3cyjA:
12.19
5ef3V-3cyjA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9h CDNA FLJ77766,
HIGHLY SIMILAR TO
HOMO SAPIENS ANKYRIN
REPEAT AND SOCS
BOX-CONTAINING 9
(ASB9), TRANSCRIPT
VARIANT 2, MRNA

(Homo sapiens) 		PF12796
(Ank_2) 		4 SER A 132
GLY A  97
HIS A 103
THR A 104
 None
 0.95A 5ef3L-3d9hA:
undetectable
5ef3V-3d9hA:
undetectable		 5ef3L-3d9hA:
13.83
5ef3V-3d9hA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 147
SER A 167
GLY A 160
ALA A 165
 None
ZN  A 302 ( 4.8A)
None
None
 0.80A 5ef3L-3dbkA:
undetectable
5ef3V-3dbkA:
undetectable		 5ef3L-3dbkA:
12.75
5ef3V-3dbkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Vibrio cholerae) 		PF02350
(Epimerase_2) 		4 THR A 100
GLY A 115
ALA A 119
THR A 143
 None
None
CL  A 374 ( 4.1A)
None
 0.85A 5ef3L-3dzcA:
undetectable
5ef3V-3dzcA:
undetectable		 5ef3L-3dzcA:
11.11
5ef3V-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 HIS A 311
ALA A 214
THR A 315
THR A 313
 None
 0.98A 5ef3L-3e60A:
undetectable
5ef3V-3e60A:
undetectable		 5ef3L-3e60A:
12.18
5ef3V-3e60A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE

(Aspergillus
niger) 		PF13714
(PEP_mutase) 		4 GLY A  47
ALA A  72
HIS A  55
THR A  50
 OAF  A 501 (-3.3A)
None
None
None
 0.90A 5ef3L-3fa3A:
undetectable
5ef3V-3fa3A:
undetectable		 5ef3L-3fa3A:
12.25
5ef3V-3fa3A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		4 GLY A 149
ALA A  38
THR A 134
THR A 145
 None
 0.64A 5ef3L-3faoA:
undetectable
5ef3V-3faoA:
undetectable		 5ef3L-3faoA:
18.44
5ef3V-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkj PUTATIVE
PHOSPHOSUGAR
ISOMERASES

(Salmonella
enterica) 		PF01380
(SIS) 		4 SER A 250
GLY A 229
HIS A 227
THR A 254
 None
 0.95A 5ef3L-3fkjA:
undetectable
5ef3V-3fkjA:
undetectable		 5ef3L-3fkjA:
14.77
5ef3V-3fkjA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 THR A 437
GLY A 337
ALA A 322
THR A 353
 None
 0.96A 5ef3L-3gcwA:
undetectable
5ef3V-3gcwA:
undetectable		 5ef3L-3gcwA:
7.93
5ef3V-3gcwA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icy SENSOR PROTEIN

(Chlorobaculum
tepidum) 		PF08447
(PAS_3) 		4 SER A  -2
GLY A 109
ALA A   0
THR A  75
 None
 0.92A 5ef3L-3icyA:
undetectable
5ef3V-3icyA:
undetectable		 5ef3L-3icyA:
23.66
5ef3V-3icyA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 SER A  66
GLY A 116
THR A  70
HIS A 121
 None
 0.63A 5ef3L-3ihaA:
undetectable
5ef3V-3ihaA:
undetectable		 5ef3L-3ihaA:
7.68
5ef3V-3ihaA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 182
HIS A 185
THR A 317
HIS A 316
 NAD  A 503 (-3.6A)
None
None
None
 0.98A 5ef3L-3jv7A:
undetectable
5ef3V-3jv7A:
undetectable		 5ef3L-3jv7A:
11.37
5ef3V-3jv7A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4u BINDING COMPONENT OF
ABC TRANSPORTER

(Wolinella
succinogenes) 		PF00497
(SBP_bac_3) 		4 THR A  71
GLY A  90
ALA A 124
THR A 185
 LYS  A 501 (-4.2A)
None
None
None
 0.84A 5ef3L-3k4uA:
undetectable
5ef3V-3k4uA:
undetectable		 5ef3L-3k4uA:
19.60
5ef3V-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 HIS A 311
ALA A 214
THR A 315
THR A 313
 None
 0.90A 5ef3L-3kzuA:
undetectable
5ef3V-3kzuA:
undetectable		 5ef3L-3kzuA:
10.51
5ef3V-3kzuA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 GLY A  37
THR A  16
HIS A  18
THR A  19
 None
 0.93A 5ef3L-3mi6A:
undetectable
5ef3V-3mi6A:
undetectable		 5ef3L-3mi6A:
6.47
5ef3V-3mi6A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1t HIT-LIKE PROTEIN
HINT

(Escherichia
coli) 		PF01230
(HIT) 		4 GLY A 107
ALA A  73
HIS A  39
THR A  38
 None
 0.96A 5ef3L-3n1tA:
undetectable
5ef3V-3n1tA:
undetectable		 5ef3L-3n1tA:
22.22
5ef3V-3n1tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02

(Pseudoalteromonas
sp. SM9913) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 352
SER A 372
GLY A 365
ALA A 370
 None
ZN  A   1 ( 4.9A)
None
None
 0.83A 5ef3L-3nqxA:
undetectable
5ef3V-3nqxA:
undetectable		 5ef3L-3nqxA:
14.98
5ef3V-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		4 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.87A 5ef3L-3ogzA:
undetectable
5ef3V-3ogzA:
undetectable		 5ef3L-3ogzA:
6.79
5ef3V-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pea ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		4 GLY A 104
HIS A 103
ALA A  23
HIS A  53
 None
 0.94A 5ef3L-3peaA:
undetectable
5ef3V-3peaA:
undetectable		 5ef3L-3peaA:
15.87
5ef3V-3peaA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r97 MALONYL COA-ACP
TRANSACYLASE

(Xanthomonas
oryzae) 		PF00698
(Acyl_transf_1) 		4 GLY A 173
ALA A 127
HIS A 203
THR A 204
 None
None
NHE  A 315 (-4.1A)
None
 0.93A 5ef3L-3r97A:
undetectable
5ef3V-3r97A:
undetectable		 5ef3L-3r97A:
13.84
5ef3V-3r97A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		4 SER A 138
GLY A 160
ALA A 140
THR A 116
 None
 0.94A 5ef3L-3rwbA:
undetectable
5ef3V-3rwbA:
undetectable		 5ef3L-3rwbA:
16.06
5ef3V-3rwbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 THR A 323
SER A 328
GLY A 279
HIS A 295
 None
 0.95A 5ef3L-3va6A:
undetectable
5ef3V-3va6A:
undetectable		 5ef3L-3va6A:
6.52
5ef3V-3va6A:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 GLY A 473
THR A 412
HIS A 411
THR A 425
 None
 0.69A 5ef3L-3vm7A:
undetectable
5ef3V-3vm7A:
undetectable		 5ef3L-3vm7A:
8.13
5ef3V-3vm7A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 SER A 385
GLY A 391
ALA A 382
THR A 410
 None
 0.69A 5ef3L-3vz0A:
undetectable
5ef3V-3vz0A:
undetectable		 5ef3L-3vz0A:
10.20
5ef3V-3vz0A:
10.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
 TRP  A  80 (-3.5A)
None
TRP  A  80 (-2.8A)
None
TRP  A  80 (-3.6A)
 0.26A 5ef3L-3zteA:
14.1
5ef3V-3zteA:
14.1		 5ef3L-3zteA:
78.21
5ef3V-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A  81 (-3.5A)
None
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 0.33A 5ef3L-3zzlA:
13.0
5ef3V-3zzlA:
13.1		 5ef3L-3zzlA:
71.43
5ef3V-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  33
ALA A  46
THR A  49
THR A  52
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
 0.20A 5ef3L-3zzqA:
13.5
5ef3V-3zzqA:
13.6		 5ef3L-3zzqA:
80.00
5ef3V-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A1072 (-3.5A)
None
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
 0.19A 5ef3L-3zzsA:
13.4
5ef3V-3zzsA:
13.5		 5ef3L-3zzsA:
100.00
5ef3V-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 SER A 322
GLY A 228
HIS A 313
THR A 314
 None
NAP  A1447 (-3.2A)
NAP  A1447 (-4.3A)
NAP  A1447 (-4.6A)
 0.94A 5ef3L-4a0sA:
undetectable
5ef3V-4a0sA:
undetectable		 5ef3L-4a0sA:
10.76
5ef3V-4a0sA:
10.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.29A 5ef3L-4b27A:
13.0
5ef3V-4b27A:
13.1		 5ef3L-4b27A:
76.32
5ef3V-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 142
SER A 162
GLY A 155
ALA A 160
 None
ZN  A 401 ( 4.9A)
None
None
 0.81A 5ef3L-4b52A:
undetectable
5ef3V-4b52A:
undetectable		 5ef3L-4b52A:
12.83
5ef3V-4b52A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 THR A 395
GLY A 400
THR A 499
THR A 449
 EDO  A1590 (-4.9A)
None
None
None
 0.74A 5ef3L-4c22A:
undetectable
5ef3V-4c22A:
undetectable		 5ef3L-4c22A:
8.11
5ef3V-4c22A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		4 THR A 206
GLY A 199
ALA A 105
HIS A 124
 None
 0.97A 5ef3L-4gdnA:
undetectable
5ef3V-4gdnA:
undetectable		 5ef3L-4gdnA:
13.55
5ef3V-4gdnA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		4 GLY A 127
ALA A  58
THR A 106
THR A 130
 FMT  A 501 (-3.4A)
None
None
None
 0.85A 5ef3L-4kv7A:
undetectable
5ef3V-4kv7A:
undetectable		 5ef3L-4kv7A:
13.40
5ef3V-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obm UNCHARACTERIZED
PROTEIN

([Eubacterium]
siraeum) 		no annotation 4 THR A  67
GLY A 113
ALA A 274
THR A 280
 None
 0.70A 5ef3L-4obmA:
undetectable
5ef3V-4obmA:
undetectable		 5ef3L-4obmA:
16.02
5ef3V-4obmA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1

(Escherichia
coli;
Homo sapiens) 		PF00003
(7tm_3)
PF07361
(Cytochrom_B562) 		4 THR A1097
GLY A1070
ALA A1037
HIS A1063
 None
 0.95A 5ef3L-4or2A:
undetectable
5ef3V-4or2A:
undetectable		 5ef3L-4or2A:
12.35
5ef3V-4or2A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		4 GLY A 213
ALA A 217
THR A 244
HIS A 209
 None
None
None
ZN  A 401 ( 3.4A)
 0.93A 5ef3L-4ov4A:
undetectable
5ef3V-4ov4A:
undetectable		 5ef3L-4ov4A:
11.11
5ef3V-4ov4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 THR B 437
GLY B 337
ALA B 322
THR B 353
 None
 0.95A 5ef3L-4ov6B:
undetectable
5ef3V-4ov6B:
undetectable		 5ef3L-4ov6B:
14.07
5ef3V-4ov6B:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		4 GLY A 348
HIS A 380
ALA A 354
HIS A 379
 None
 0.90A 5ef3L-4rqoA:
undetectable
5ef3V-4rqoA:
undetectable		 5ef3L-4rqoA:
10.45
5ef3V-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 THR A 408
SER A 305
ALA A 301
THR A 454
 None
 0.92A 5ef3L-4uzsA:
undetectable
5ef3V-4uzsA:
undetectable		 5ef3L-4uzsA:
6.82
5ef3V-4uzsA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		4 THR A 264
SER A 282
GLY A 249
ALA A 255
 None
 0.92A 5ef3L-4wt7A:
undetectable
5ef3V-4wt7A:
undetectable		 5ef3L-4wt7A:
11.53
5ef3V-4wt7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		4 THR A 195
GLY A 162
ALA A 167
THR A 150
 None
 0.93A 5ef3L-4yjiA:
undetectable
5ef3V-4yjiA:
undetectable		 5ef3L-4yjiA:
9.31
5ef3V-4yjiA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 149
SER A 169
GLY A 162
ALA A 167
 None
ZN  A1317 ( 4.6A)
None
None
 0.86A 5ef3L-5a3yA:
undetectable
5ef3V-5a3yA:
undetectable		 5ef3L-5a3yA:
7.66
5ef3V-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 292
GLY A 441
THR A 449
THR A 445
 None
PO4  A 701 (-3.5A)
None
None
 0.66A 5ef3L-5c16A:
undetectable
5ef3V-5c16A:
undetectable		 5ef3L-5c16A:
8.93
5ef3V-5c16A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c69 FUSION GLYCOPROTEIN
F0,FIBRITIN

(Enterobacteria
phage Ox2;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 SER A 323
GLY A 280
THR A 342
THR A  50
 None
 0.87A 5ef3L-5c69A:
undetectable
5ef3V-5c69A:
undetectable		 5ef3L-5c69A:
11.00
5ef3V-5c69A:
11.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 None
 0.21A 5ef3L-5eexA:
15.8
5ef3V-5eexA:
15.8		 5ef3L-5eexA:
100.00
5ef3V-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftx SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 GLY A 522
ALA A 487
THR A 455
THR A 484
 None
 0.91A 5ef3L-5ftxA:
undetectable
5ef3V-5ftxA:
undetectable		 5ef3L-5ftxA:
7.99
5ef3V-5ftxA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		4 SER A 148
GLY A 127
HIS A 153
THR A 154
 SAH  A 409 ( 4.2A)
None
None
None
 0.76A 5ef3L-5fubA:
undetectable
5ef3V-5fubA:
undetectable		 5ef3L-5fubA:
14.50
5ef3V-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		4 SER A 182
GLY A 161
HIS A 187
THR A 188
 SAH  A1446 ( 4.4A)
None
None
None
 0.76A 5ef3L-5fulA:
undetectable
5ef3V-5fulA:
undetectable		 5ef3L-5fulA:
10.25
5ef3V-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 149
SER A 169
GLY A 162
ALA A 167
 None
ZN  A1317 ( 4.7A)
None
None
 0.87A 5ef3L-5fxnA:
undetectable
5ef3V-5fxnA:
undetectable		 5ef3L-5fxnA:
10.79
5ef3V-5fxnA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		4 GLY A  62
ALA A  58
THR A  84
THR A  48
 None
 0.88A 5ef3L-5gkxA:
undetectable
5ef3V-5gkxA:
undetectable		 5ef3L-5gkxA:
16.60
5ef3V-5gkxA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		4 GLY A 274
ALA A 400
THR A 377
THR A 308
 None
 0.78A 5ef3L-5j84A:
undetectable
5ef3V-5j84A:
undetectable		 5ef3L-5j84A:
8.03
5ef3V-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 GLY A 635
ALA A 648
THR A 570
HIS A 638
 None
 0.68A 5ef3L-5jxfA:
undetectable
5ef3V-5jxfA:
undetectable		 5ef3L-5jxfA:
7.11
5ef3V-5jxfA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Rhinovirus C;
Rhinovirus C) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 THR A 243
SER A 247
GLY C 136
ALA C 133
 None
 0.90A 5ef3L-5k0uA:
1.6
5ef3V-5k0uA:
1.6		 5ef3L-5k0uA:
15.02
5ef3V-5k0uA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt9 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTB

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 GLY A 171
ALA A 132
THR A 141
THR A 155
 None
 0.89A 5ef3L-5lt9A:
undetectable
5ef3V-5lt9A:
undetectable		 5ef3L-5lt9A:
12.90
5ef3V-5lt9A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		4 GLY A 147
HIS A 128
ALA A 169
THR A 166
 None
 0.82A 5ef3L-5m23A:
undetectable
5ef3V-5m23A:
undetectable		 5ef3L-5m23A:
9.88
5ef3V-5m23A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 4 THR A 146
GLY A 372
ALA A 399
THR A 376
 None
MG  A1002 (-3.5A)
None
None
 0.93A 5ef3L-5nlmA:
undetectable
5ef3V-5nlmA:
undetectable		 5ef3L-5nlmA:
undetectable
5ef3V-5nlmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 4 GLY A 797
ALA A 896
THR A 801
THR A 800
 None
 0.98A 5ef3L-5nprA:
undetectable
5ef3V-5nprA:
undetectable		 5ef3L-5nprA:
undetectable
5ef3V-5nprA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nuv AUTOPHAGY-RELATED
PROTEIN 16-1

(Homo sapiens) 		PF00400
(WD40) 		4 GLY A 426
HIS A 407
ALA A 448
THR A 445
 None
 0.87A 5ef3L-5nuvA:
undetectable
5ef3V-5nuvA:
undetectable		 5ef3L-5nuvA:
12.58
5ef3V-5nuvA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.87A 5ef3L-5o0sA:
undetectable
5ef3V-5o0sA:
0.4		 5ef3L-5o0sA:
6.51
5ef3V-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 GLY A  86
HIS A 159
ALA A  77
THR A  81
 None
 0.96A 5ef3L-5t9gA:
undetectable
5ef3V-5t9gA:
undetectable		 5ef3L-5t9gA:
6.74
5ef3V-5t9gA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		4 GLY A 525
HIS A 311
ALA A 274
THR A 347
 None
 0.89A 5ef3L-5v1wA:
undetectable
5ef3V-5v1wA:
undetectable		 5ef3L-5v1wA:
8.11
5ef3V-5v1wA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 THR A 437
GLY A 337
ALA A 322
THR A 353
 None
 0.96A 5ef3L-5vlhA:
undetectable
5ef3V-5vlhA:
undetectable		 5ef3L-5vlhA:
9.83
5ef3V-5vlhA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Saccharum
hybrid cultivar) 		no annotation 4 GLY A  94
THR A 150
HIS A 147
THR A 146
 None
 0.92A 5ef3L-5wegA:
undetectable
5ef3V-5wegA:
undetectable		 5ef3L-5wegA:
undetectable
5ef3V-5wegA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC

(Pisum sativum) 		PF01716
(MSP) 		4 SER O 196
GLY O 229
ALA O 194
THR O 226
 None
 0.93A 5ef3L-5xnlO:
undetectable
5ef3V-5xnlO:
undetectable		 5ef3L-5xnlO:
16.88
5ef3V-5xnlO:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1

(Homo sapiens) 		no annotation 4 GLY A 280
HIS A 261
ALA A 303
THR A 299
 None
 0.80A 5ef3L-6b3xA:
undetectable
5ef3V-6b3xA:
undetectable		 5ef3L-6b3xA:
15.69
5ef3V-6b3xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byn WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 4 GLY W 147
HIS W 128
ALA W 169
THR W 166
 None
 0.82A 5ef3L-6bynW:
undetectable
5ef3V-6bynW:
undetectable		 5ef3L-6bynW:
undetectable
5ef3V-6bynW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 4 SER A 421
GLY A  12
ALA A  20
THR A 259
 None
FAD  A 507 (-3.4A)
None
None
 0.93A 5ef3L-6cr0A:
undetectable
5ef3V-6cr0A:
undetectable		 5ef3L-6cr0A:
10.14
5ef3V-6cr0A:
10.14