SIMILAR PATTERNS OF AMINO ACIDS FOR 5EF2_L_TRPL101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 SER A 643
HIS A 147
HIS A 167
THR A 168
 FLC  A 756 (-2.8A)
None
O  A1100 ( 3.9A)
None
 0.84A 5ef2L-1b0kA:
undetectable
5ef2V-1b0kA:
undetectable		 5ef2L-1b0kA:
8.16
5ef2V-1b0kA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 THR A  82
GLY A 118
ALA A  25
THR A 125
 None
 0.68A 5ef2L-1c3xA:
undetectable
5ef2V-1c3xA:
undetectable		 5ef2L-1c3xA:
14.98
5ef2V-1c3xA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 SER A 104
GLY A 177
ALA A 102
HIS A 238
 None
 0.87A 5ef2L-1ex9A:
undetectable
5ef2V-1ex9A:
undetectable		 5ef2L-1ex9A:
15.66
5ef2V-1ex9A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 GLY A 344
ALA A 318
HIS A 283
THR A 284
 None
 0.67A 5ef2L-1f26A:
undetectable
5ef2V-1f26A:
undetectable		 5ef2L-1f26A:
11.72
5ef2V-1f26A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 SER A  57
ALA A  60
HIS A  34
THR A  35
 None
 0.86A 5ef2L-1i9gA:
1.2
5ef2V-1i9gA:
1.2		 5ef2L-1i9gA:
15.33
5ef2V-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 GLY A  46
HIS A  38
ALA A  51
THR A 299
 None
 0.87A 5ef2L-1iduA:
undetectable
5ef2V-1iduA:
undetectable		 5ef2L-1iduA:
8.08
5ef2V-1iduA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 THR A 417
SER A 245
GLY A 412
ALA A 510
THR A 500
 TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
None
None
None
 1.10A 5ef2L-1l5jA:
undetectable
5ef2V-1l5jA:
undetectable		 5ef2L-1l5jA:
7.07
5ef2V-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PO4  A 655 (-3.6A)
None
None
 0.77A 5ef2L-1lw3A:
undetectable
5ef2V-1lw3A:
undetectable		 5ef2L-1lw3A:
7.46
5ef2V-1lw3A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 THR A 389
SER A 384
GLY A  11
THR A 156
 None
 0.81A 5ef2L-1mb9A:
0.0
5ef2V-1mb9A:
0.0		 5ef2L-1mb9A:
9.16
5ef2V-1mb9A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 GLY B 156
ALA B 151
THR B 139
HIS B 103
THR B 137
 None
 1.30A 5ef2L-1mioB:
undetectable
5ef2V-1mioB:
undetectable		 5ef2L-1mioB:
9.76
5ef2V-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 THR Q 376
GLY Q 105
ALA Q  96
THR Q  99
 None
 0.75A 5ef2L-1oh2Q:
undetectable
5ef2V-1oh2Q:
undetectable		 5ef2L-1oh2Q:
12.04
5ef2V-1oh2Q:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 THR A  52
GLY A  61
ALA A  84
HIS A  55
 None
 0.85A 5ef2L-1qh5A:
undetectable
5ef2V-1qh5A:
undetectable		 5ef2L-1qh5A:
14.90
5ef2V-1qh5A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 THR A 679
GLY A 284
HIS A 282
ALA A 312
THR A 351
 None
 1.48A 5ef2L-1sb3A:
undetectable
5ef2V-1sb3A:
undetectable		 5ef2L-1sb3A:
7.84
5ef2V-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 THR A  40
GLY A 188
ALA A 196
THR A  49
THR A 183
 None
 1.15A 5ef2L-1v9cA:
undetectable
5ef2V-1v9cA:
undetectable		 5ef2L-1v9cA:
19.25
5ef2V-1v9cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.71A 5ef2L-1zsqA:
undetectable
5ef2V-1zsqA:
undetectable		 5ef2L-1zsqA:
12.02
5ef2V-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 319
GLY A 182
ALA A 208
THR A 185
 None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
 0.79A 5ef2L-2eerA:
undetectable
5ef2V-2eerA:
undetectable		 5ef2L-2eerA:
13.02
5ef2V-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 GLY B 677
ALA B 688
THR B 417
HIS B 682
 None
None
None
NI  B 901 (-2.8A)
 0.87A 5ef2L-2fffB:
undetectable
5ef2V-2fffB:
undetectable		 5ef2L-2fffB:
11.03
5ef2V-2fffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus;
Lupinus luteus) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		5 GLY B 195
HIS A   9
ALA A  67
THR B 225
THR B 209
 None
None
NA  A 401 (-4.6A)
None
None
 1.40A 5ef2L-2gezB:
undetectable
5ef2V-2gezB:
undetectable		 5ef2L-2gezB:
20.15
5ef2V-2gezB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 SER A 492
GLY A 577
HIS A 496
ALA A 580
 EDO  A 621 ( 4.6A)
EDO  A 619 (-3.2A)
None
EDO  A 624 (-3.5A)
 0.85A 5ef2L-2gmhA:
undetectable
5ef2V-2gmhA:
undetectable		 5ef2L-2gmhA:
8.82
5ef2V-2gmhA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLY A  23
HIS A  59
ALA A  87
HIS A  58
 None
 0.78A 5ef2L-2i3aA:
undetectable
5ef2V-2i3aA:
undetectable		 5ef2L-2i3aA:
12.78
5ef2V-2i3aA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Arabidopsis
thaliana) 		PF01704
(UDPGP) 		4 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.85A 5ef2L-2icyA:
undetectable
5ef2V-2icyA:
undetectable		 5ef2L-2icyA:
12.69
5ef2V-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 4 GLY A 373
ALA A 176
HIS A 200
THR A 205
 None
 0.86A 5ef2L-2iouA:
undetectable
5ef2V-2iouA:
undetectable		 5ef2L-2iouA:
12.77
5ef2V-2iouA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 SER A 198
GLY A 276
THR A 107
HIS A 134
 None
 0.88A 5ef2L-2qfvA:
0.0
5ef2V-2qfvA:
undetectable		 5ef2L-2qfvA:
11.53
5ef2V-2qfvA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzn VENOM ALLERGEN 3

(Solenopsis
invicta) 		PF00188
(CAP) 		4 SER A  34
GLY A 122
HIS A 190
THR A 188
 None
 0.89A 5ef2L-2vznA:
undetectable
5ef2V-2vznA:
undetectable		 5ef2L-2vznA:
18.46
5ef2V-2vznA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 THR A 191
GLY A 232
HIS A 244
THR A 245
 None
PEG  A1779 (-4.4A)
FMT  A1766 (-3.9A)
None
 0.87A 5ef2L-2wdaA:
undetectable
5ef2V-2wdaA:
undetectable		 5ef2L-2wdaA:
6.68
5ef2V-2wdaA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 SER A 402
GLY A 435
ALA A 407
THR A 442
THR A 439
 None
ADP  A1854 (-3.1A)
ADP  A1854 ( 4.5A)
None
None
 1.26A 5ef2L-2xzlA:
undetectable
5ef2V-2xzlA:
undetectable		 5ef2L-2xzlA:
7.24
5ef2V-2xzlA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 SER A  62
ALA A  60
HIS A  83
THR A  84
 None
 0.76A 5ef2L-2yk0A:
undetectable
5ef2V-2yk0A:
undetectable		 5ef2L-2yk0A:
6.32
5ef2V-2yk0A:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 THR A 112
SER A  74
GLY A 166
THR A 178
THR A 179
 NAD  A3001 ( 4.5A)
None
NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
 1.34A 5ef2L-3a1nA:
undetectable
5ef2V-3a1nA:
undetectable		 5ef2L-3a1nA:
13.02
5ef2V-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 SER A 251
GLY A 301
ALA A 292
THR A 358
 None
 0.86A 5ef2L-3afgA:
2.9
5ef2V-3afgA:
3.0		 5ef2L-3afgA:
11.86
5ef2V-3afgA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 SER A 411
GLY A 417
ALA A 408
THR A 436
 None
 0.86A 5ef2L-3b4wA:
undetectable
5ef2V-3b4wA:
undetectable		 5ef2L-3b4wA:
10.29
5ef2V-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 147
SER A 167
GLY A 160
ALA A 165
 None
ZN  A 302 ( 4.8A)
None
None
 0.81A 5ef2L-3dbkA:
undetectable
5ef2V-3dbkA:
undetectable		 5ef2L-3dbkA:
12.75
5ef2V-3dbkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Vibrio cholerae) 		PF02350
(Epimerase_2) 		4 THR A 100
GLY A 115
ALA A 119
THR A 143
 None
None
CL  A 374 ( 4.1A)
None
 0.85A 5ef2L-3dzcA:
undetectable
5ef2V-3dzcA:
undetectable		 5ef2L-3dzcA:
11.11
5ef2V-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 SER A 214
GLY A 208
ALA A 212
THR A 239
HIS A 204
 None
 1.32A 5ef2L-3eegA:
undetectable
5ef2V-3eegA:
undetectable		 5ef2L-3eegA:
17.23
5ef2V-3eegA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		4 GLY A 149
ALA A  38
THR A 134
THR A 145
 None
 0.64A 5ef2L-3faoA:
undetectable
5ef2V-3faoA:
undetectable		 5ef2L-3faoA:
18.44
5ef2V-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 SER A 277
GLY A  77
ALA A 316
THR A 234
 None
 0.78A 5ef2L-3fpzA:
undetectable
5ef2V-3fpzA:
undetectable		 5ef2L-3fpzA:
16.03
5ef2V-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 ALA A  72
THR A 332
HIS A 329
THR A 328
 None
 0.83A 5ef2L-3gveA:
undetectable
5ef2V-3gveA:
undetectable		 5ef2L-3gveA:
12.61
5ef2V-3gveA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 SER A  66
GLY A 116
THR A  70
HIS A 121
 None
 0.63A 5ef2L-3ihaA:
undetectable
5ef2V-3ihaA:
undetectable		 5ef2L-3ihaA:
7.68
5ef2V-3ihaA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4u BINDING COMPONENT OF
ABC TRANSPORTER

(Wolinella
succinogenes) 		PF00497
(SBP_bac_3) 		4 THR A  71
GLY A  90
ALA A 124
THR A 185
 LYS  A 501 (-4.2A)
None
None
None
 0.84A 5ef2L-3k4uA:
undetectable
5ef2V-3k4uA:
undetectable		 5ef2L-3k4uA:
19.60
5ef2V-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 SER A 153
GLY A 184
ALA A 155
THR A 236
 None
 0.87A 5ef2L-3k96A:
undetectable
5ef2V-3k96A:
undetectable		 5ef2L-3k96A:
13.90
5ef2V-3k96A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02

(Pseudoalteromonas
sp. SM9913) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 352
SER A 372
GLY A 365
ALA A 370
 None
ZN  A   1 ( 4.9A)
None
None
 0.83A 5ef2L-3nqxA:
undetectable
5ef2V-3nqxA:
undetectable		 5ef2L-3nqxA:
14.98
5ef2V-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		4 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.87A 5ef2L-3ogzA:
undetectable
5ef2V-3ogzA:
undetectable		 5ef2L-3ogzA:
6.79
5ef2V-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		4 GLY A 103
THR A 110
HIS A 107
THR A 106
 None
 0.86A 5ef2L-3p3lA:
undetectable
5ef2V-3p3lA:
undetectable		 5ef2L-3p3lA:
10.84
5ef2V-3p3lA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 THR A 165
SER A 138
GLY A 160
ALA A 140
THR A 116
 None
 1.19A 5ef2L-3rwbA:
undetectable
5ef2V-3rwbA:
undetectable		 5ef2L-3rwbA:
16.06
5ef2V-3rwbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 GLY A  64
ALA A 118
THR A  75
THR A  74
 None
 0.85A 5ef2L-3slkA:
undetectable
5ef2V-3slkA:
undetectable		 5ef2L-3slkA:
6.42
5ef2V-3slkA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		4 GLY A 446
ALA A 468
THR A 480
HIS A 460
 FDA  A 600 (-3.2A)
None
None
None
 0.81A 5ef2L-3ukfA:
undetectable
5ef2V-3ukfA:
undetectable		 5ef2L-3ukfA:
11.33
5ef2V-3ukfA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 GLY A 473
THR A 412
HIS A 411
THR A 425
 None
 0.69A 5ef2L-3vm7A:
undetectable
5ef2V-3vm7A:
undetectable		 5ef2L-3vm7A:
8.13
5ef2V-3vm7A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 SER A 385
GLY A 391
ALA A 382
THR A 410
 None
 0.69A 5ef2L-3vz0A:
undetectable
5ef2V-3vz0A:
undetectable		 5ef2L-3vz0A:
10.20
5ef2V-3vz0A:
10.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
 TRP  A  80 (-3.5A)
None
TRP  A  80 (-2.8A)
None
TRP  A  80 (-3.6A)
 0.26A 5ef2L-3zteA:
14.1
5ef2V-3zteA:
14.2		 5ef2L-3zteA:
78.21
5ef2V-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A  81 (-3.5A)
None
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 0.33A 5ef2L-3zzlA:
13.0
5ef2V-3zzlA:
13.1		 5ef2L-3zzlA:
71.43
5ef2V-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  33
ALA A  46
THR A  49
THR A  52
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
 0.20A 5ef2L-3zzqA:
13.6
5ef2V-3zzqA:
13.6		 5ef2L-3zzqA:
80.00
5ef2V-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A1072 (-3.5A)
None
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
 0.19A 5ef2L-3zzsA:
13.4
5ef2V-3zzsA:
13.5		 5ef2L-3zzsA:
100.00
5ef2V-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A 322
GLY A 228
HIS A 313
THR A 318
THR A 314
 None
NAP  A1447 (-3.2A)
NAP  A1447 (-4.3A)
None
NAP  A1447 (-4.6A)
 1.30A 5ef2L-4a0sA:
undetectable
5ef2V-4a0sA:
undetectable		 5ef2L-4a0sA:
10.76
5ef2V-4a0sA:
10.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5ef2L-4b27A:
13.0
5ef2V-4b27A:
13.1		 5ef2L-4b27A:
76.32
5ef2V-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 142
SER A 162
GLY A 155
ALA A 160
 None
ZN  A 401 ( 4.9A)
None
None
 0.81A 5ef2L-4b52A:
undetectable
5ef2V-4b52A:
undetectable		 5ef2L-4b52A:
12.83
5ef2V-4b52A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 SER A 132
HIS A  55
HIS A  53
THR A  62
 None
 0.81A 5ef2L-4bc5A:
undetectable
5ef2V-4bc5A:
undetectable		 5ef2L-4bc5A:
9.72
5ef2V-4bc5A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 THR A 395
GLY A 400
THR A 499
THR A 449
 EDO  A1590 (-4.9A)
None
None
None
 0.74A 5ef2L-4c22A:
undetectable
5ef2V-4c22A:
undetectable		 5ef2L-4c22A:
8.11
5ef2V-4c22A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		4 GLY A 121
ALA A 128
THR A 117
THR A 119
 None
 0.89A 5ef2L-4d9iA:
undetectable
5ef2V-4d9iA:
undetectable		 5ef2L-4d9iA:
11.42
5ef2V-4d9iA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 GLY A 422
ALA A 444
THR A 457
HIS A 436
 FDA  A 502 (-3.3A)
None
None
None
 0.87A 5ef2L-4dshA:
undetectable
5ef2V-4dshA:
undetectable		 5ef2L-4dshA:
9.36
5ef2V-4dshA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2p CYTOCHROME P450
107B1 (P450CVIIB1)

(Streptomyces
himastatinicus) 		PF00067
(p450) 		4 THR A 286
GLY A 340
ALA A  43
HIS A 344
 HEM  A 401 (-3.3A)
HEM  A 401 ( 4.1A)
None
HEM  A 401 (-3.9A)
 0.84A 5ef2L-4e2pA:
undetectable
5ef2V-4e2pA:
undetectable		 5ef2L-4e2pA:
10.50
5ef2V-4e2pA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		4 THR A 118
GLY A  90
ALA A  74
THR A  82
 None
 0.87A 5ef2L-4ee8A:
undetectable
5ef2V-4ee8A:
undetectable		 5ef2L-4ee8A:
15.19
5ef2V-4ee8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 SER A 199
GLY A 277
THR A 109
HIS A 136
 None
 0.87A 5ef2L-4hcxA:
undetectable
5ef2V-4hcxA:
undetectable		 5ef2L-4hcxA:
11.49
5ef2V-4hcxA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16227
(DUF4886) 		4 SER A 214
GLY A 232
ALA A 270
HIS A 219
 None
 0.87A 5ef2L-4i8iA:
undetectable
5ef2V-4i8iA:
undetectable		 5ef2L-4i8iA:
16.42
5ef2V-4i8iA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		4 THR A 239
GLY A 267
THR A 229
THR A 270
 ADP  A 601 (-2.9A)
ADP  A 601 (-3.1A)
None
ADP  A 601 (-3.2A)
 0.77A 5ef2L-4ihqA:
undetectable
5ef2V-4ihqA:
undetectable		 5ef2L-4ihqA:
11.31
5ef2V-4ihqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 THR A 117
GLY B 137
ALA B 134
HIS B 162
 None
 0.80A 5ef2L-4jy4A:
undetectable
5ef2V-4jy4A:
undetectable		 5ef2L-4jy4A:
16.75
5ef2V-4jy4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		4 GLY A 127
ALA A  58
THR A 106
THR A 130
 FMT  A 501 (-3.4A)
None
None
None
 0.85A 5ef2L-4kv7A:
undetectable
5ef2V-4kv7A:
undetectable		 5ef2L-4kv7A:
13.40
5ef2V-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6q HASAP

(Pseudomonas
aeruginosa) 		PF06438
(HasA) 		4 GLY A 128
THR A  76
HIS A  83
THR A  84
 None
None
HEM  A 202 ( 3.5A)
None
 0.85A 5ef2L-4o6qA:
undetectable
5ef2V-4o6qA:
undetectable		 5ef2L-4o6qA:
18.72
5ef2V-4o6qA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obm UNCHARACTERIZED
PROTEIN

([Eubacterium]
siraeum) 		no annotation 4 THR A  67
GLY A 113
ALA A 274
THR A 280
 None
 0.70A 5ef2L-4obmA:
undetectable
5ef2V-4obmA:
undetectable		 5ef2L-4obmA:
16.02
5ef2V-4obmA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		5 SER A 219
GLY A 213
ALA A 217
THR A 244
HIS A 209
 None
None
None
None
ZN  A 401 ( 3.4A)
 1.14A 5ef2L-4ov4A:
undetectable
5ef2V-4ov4A:
undetectable		 5ef2L-4ov4A:
11.11
5ef2V-4ov4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 THR A  79
ALA A  23
HIS A  53
THR A  35
 None
 0.88A 5ef2L-4qn3A:
undetectable
5ef2V-4qn3A:
undetectable		 5ef2L-4qn3A:
12.90
5ef2V-4qn3A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r58 LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		4 HIS A 176
THR A 133
HIS A 154
THR A 155
 None
 0.88A 5ef2L-4r58A:
undetectable
5ef2V-4r58A:
undetectable		 5ef2L-4r58A:
15.91
5ef2V-4r58A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 THR A 442
GLY A 289
ALA A 589
THR A 583
 None
BEF  A1732 (-3.0A)
None
BEF  A1732 (-4.2A)
 0.80A 5ef2L-4umvA:
undetectable
5ef2V-4umvA:
undetectable		 5ef2L-4umvA:
7.07
5ef2V-4umvA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfj ARGININOSUCCINATE
SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00764
(Arginosuc_synth) 		4 SER A 355
GLY A 225
THR A 291
HIS A 334
 None
 0.75A 5ef2L-4xfjA:
undetectable
5ef2V-4xfjA:
undetectable		 5ef2L-4xfjA:
8.68
5ef2V-4xfjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00106
(adh_short) 		5 THR A 169
SER A 142
GLY A 164
ALA A 144
THR A 115
 None
 1.12A 5ef2L-4xgnA:
undetectable
5ef2V-4xgnA:
undetectable		 5ef2L-4xgnA:
13.85
5ef2V-4xgnA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 THR A 405
GLY A 251
ALA A 430
HIS A 453
 None
 0.82A 5ef2L-4yweA:
undetectable
5ef2V-4yweA:
undetectable		 5ef2L-4yweA:
8.54
5ef2V-4yweA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs7 LLAMA FAB FRAGMENT
68F2 HEAVY CHAIN
LLAMA FAB FRAGMENT
68F2 LIGHT CHAIN

(Lama glama;
Lama glama) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 THR L 120
GLY H 148
ALA H 145
HIS H 173
 None
 0.87A 5ef2L-4zs7L:
undetectable
5ef2V-4zs7L:
undetectable		 5ef2L-4zs7L:
15.38
5ef2V-4zs7L:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 149
SER A 169
GLY A 162
ALA A 167
 None
ZN  A1317 ( 4.6A)
None
None
 0.86A 5ef2L-5a3yA:
undetectable
5ef2V-5a3yA:
undetectable		 5ef2L-5a3yA:
7.66
5ef2V-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 292
GLY A 441
THR A 449
THR A 445
 None
PO4  A 701 (-3.5A)
None
None
 0.65A 5ef2L-5c16A:
undetectable
5ef2V-5c16A:
undetectable		 5ef2L-5c16A:
8.93
5ef2V-5c16A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c69 FUSION GLYCOPROTEIN
F0,FIBRITIN

(Enterobacteria
phage Ox2;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 SER A 323
GLY A 280
THR A 342
THR A  50
 None
 0.87A 5ef2L-5c69A:
undetectable
5ef2V-5c69A:
undetectable		 5ef2L-5c69A:
11.00
5ef2V-5c69A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 GLY A 375
HIS A 374
ALA A 337
THR A 325
 None
 0.89A 5ef2L-5dfaA:
0.8
5ef2V-5dfaA:
undetectable		 5ef2L-5dfaA:
6.85
5ef2V-5dfaA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 THR A 674
GLY A 758
ALA A 741
HIS A 647
THR A 756
 None
 1.41A 5ef2L-5dmyA:
1.4
5ef2V-5dmyA:
1.6		 5ef2L-5dmyA:
6.41
5ef2V-5dmyA:
6.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 None
 0.21A 5ef2L-5eexA:
15.7
5ef2V-5eexA:
15.8		 5ef2L-5eexA:
100.00
5ef2V-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		4 SER A 148
GLY A 127
HIS A 153
THR A 154
 SAH  A 409 ( 4.2A)
None
None
None
 0.75A 5ef2L-5fubA:
undetectable
5ef2V-5fubA:
undetectable		 5ef2L-5fubA:
14.50
5ef2V-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		4 SER A 182
GLY A 161
HIS A 187
THR A 188
 SAH  A1446 ( 4.4A)
None
None
None
 0.76A 5ef2L-5fulA:
undetectable
5ef2V-5fulA:
undetectable		 5ef2L-5fulA:
10.25
5ef2V-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 THR A 149
SER A 169
GLY A 162
ALA A 167
 None
ZN  A1317 ( 4.7A)
None
None
 0.87A 5ef2L-5fxnA:
undetectable
5ef2V-5fxnA:
undetectable		 5ef2L-5fxnA:
10.79
5ef2V-5fxnA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00466
(Ribosomal_L10) 		4 THR i 266
GLY i  87
ALA i 259
HIS i 264
 None
 0.84A 5ef2L-5gafi:
undetectable
5ef2V-5gafi:
undetectable		 5ef2L-5gafi:
12.30
5ef2V-5gafi:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		4 GLY A  62
ALA A  58
THR A  84
THR A  48
 None
 0.88A 5ef2L-5gkxA:
undetectable
5ef2V-5gkxA:
undetectable		 5ef2L-5gkxA:
16.60
5ef2V-5gkxA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		4 GLY A 274
ALA A 400
THR A 377
THR A 308
 None
 0.77A 5ef2L-5j84A:
undetectable
5ef2V-5j84A:
undetectable		 5ef2L-5j84A:
8.03
5ef2V-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwy PHOSPHATIDYLGLYCEROP
HOSPHATASE B

(Escherichia
coli) 		PF01569
(PAP2) 		4 THR A  47
GLY A 196
ALA A  40
HIS A 163
 None
None
None
46E  A 301 ( 3.9A)
 0.89A 5ef2L-5jwyA:
undetectable
5ef2V-5jwyA:
undetectable		 5ef2L-5jwyA:
13.90
5ef2V-5jwyA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 GLY A 635
ALA A 648
THR A 570
HIS A 638
 None
 0.68A 5ef2L-5jxfA:
undetectable
5ef2V-5jxfA:
undetectable		 5ef2L-5jxfA:
7.11
5ef2V-5jxfA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt9 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTB

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 GLY A 171
ALA A 132
THR A 141
THR A 155
 None
 0.89A 5ef2L-5lt9A:
undetectable
5ef2V-5lt9A:
undetectable		 5ef2L-5lt9A:
12.90
5ef2V-5lt9A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		4 GLY A 147
HIS A 128
ALA A 169
THR A 166
 None
 0.82A 5ef2L-5m23A:
undetectable
5ef2V-5m23A:
undetectable		 5ef2L-5m23A:
9.88
5ef2V-5m23A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nuv AUTOPHAGY-RELATED
PROTEIN 16-1

(Homo sapiens) 		PF00400
(WD40) 		4 GLY A 426
HIS A 407
ALA A 448
THR A 445
 None
 0.87A 5ef2L-5nuvA:
undetectable
5ef2V-5nuvA:
undetectable		 5ef2L-5nuvA:
12.58
5ef2V-5nuvA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.87A 5ef2L-5o0sA:
undetectable
5ef2V-5o0sA:
0.4		 5ef2L-5o0sA:
6.51
5ef2V-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 GLY A 171
ALA A 132
THR A 141
THR A 155
 None
 0.87A 5ef2L-5t65A:
undetectable
5ef2V-5t65A:
undetectable		 5ef2L-5t65A:
15.76
5ef2V-5t65A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 THR A 210
SER A 132
ALA A 144
THR A 136
THR A 137
 None
 1.45A 5ef2L-5ujuA:
undetectable
5ef2V-5ujuA:
undetectable		 5ef2L-5ujuA:
8.35
5ef2V-5ujuA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 5 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5ef2L-5wh8A:
undetectable
5ef2V-5wh8A:
undetectable		 5ef2L-5wh8A:
undetectable
5ef2V-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 4 GLY A 126
ALA A 133
THR A 122
THR A 124
 PO4  A 504 (-4.5A)
None
None
PO4  A 504 (-3.6A)
 0.89A 5ef2L-5ygrA:
undetectable
5ef2V-5ygrA:
undetectable		 5ef2L-5ygrA:
undetectable
5ef2V-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6o PROTEASE

(Penicillium
cyclopium) 		no annotation 4 SER A 193
GLY A 200
ALA A 185
THR A 271
 None
 0.89A 5ef2L-5z6oA:
undetectable
5ef2V-5z6oA:
undetectable		 5ef2L-5z6oA:
undetectable
5ef2V-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1

(Homo sapiens) 		no annotation 4 GLY A 280
HIS A 261
ALA A 303
THR A 299
 None
 0.80A 5ef2L-6b3xA:
undetectable
5ef2V-6b3xA:
undetectable		 5ef2L-6b3xA:
15.69
5ef2V-6b3xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byn WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 4 GLY W 147
HIS W 128
ALA W 169
THR W 166
 None
 0.82A 5ef2L-6bynW:
undetectable
5ef2V-6bynW:
undetectable		 5ef2L-6bynW:
undetectable
5ef2V-6bynW:
undetectable