SIMILAR PATTERNS OF AMINO ACIDS FOR 5EEZ_F_TRPF101_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezi | CMP-N-ACETYLNEURAMINIC ACID SYNTHETASE (Neisseriameningitidis) |
PF02348(CTP_transf_3) | 5 | ALA A 177GLY A 112HIS A 114THR A 35HIS A 34 | None | 1.12A | 5eezF-1eziA:undetectable5eezG-1eziA:undetectable | 5eezF-1eziA:17.035eezG-1eziA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezi | CMP-N-ACETYLNEURAMINIC ACID SYNTHETASE (Neisseriameningitidis) |
PF02348(CTP_transf_3) | 5 | ALA A 177GLY A 112THR A 35HIS A 34ILE A 115 | None | 1.11A | 5eezF-1eziA:undetectable5eezG-1eziA:undetectable | 5eezF-1eziA:17.035eezG-1eziA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fui | L-FUCOSE ISOMERASE (Escherichiacoli) |
PF02952(Fucose_iso_C)PF07881(Fucose_iso_N1)PF07882(Fucose_iso_N2) | 5 | ALA A 123GLY A 109ALA A 124THR A 87ILE A 107 | None | 1.19A | 5eezF-1fuiA:undetectable5eezG-1fuiA:0.0 | 5eezF-1fuiA:8.975eezG-1fuiA:8.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1knr | L-ASPARTATE OXIDASE (Escherichiacoli) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | THR A 259SER A 389ALA A 388GLY A 264THR A 119 | CL A 541 (-3.9A)FAD A 800 (-4.3A)NoneNoneNone | 1.13A | 5eezF-1knrA:undetectable5eezG-1knrA:0.0 | 5eezF-1knrA:9.075eezG-1knrA:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 5 | THR A 417SER A 245GLY A 412ALA A 510THR A 500 | TRA A 866 (-4.0A)TRA A 866 (-2.6A)NoneNoneNone | 1.14A | 5eezF-1l5jA:undetectable5eezG-1l5jA:0.0 | 5eezF-1l5jA:7.075eezG-1l5jA:7.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odi | PURINE NUCLEOSIDEPHOSPHORYLASE (Thermusthermophilus) |
PF01048(PNP_UDP_1) | 5 | SER A 95ALA A 94GLY A 151ALA A 177ILE A 104 | None | 1.00A | 5eezF-1odiA:undetectable5eezG-1odiA:undetectable | 5eezF-1odiA:14.715eezG-1odiA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8f | PYRIMIDINENUCLEOSIDE HYDROLASE (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 5 | THR A 287GLY A 152ALA A 174THR A 273ILE A 167 | None | 1.10A | 5eezF-1q8fA:undetectable5eezG-1q8fA:undetectable | 5eezF-1q8fA:13.505eezG-1q8fA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r0l | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Zymomonasmobilis) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | THR A 8ALA A 90GLY A 11ALA A 109ILE A 101 | NoneNoneNDP A 400 (-3.1A)NoneNDP A 400 (-3.9A) | 1.08A | 5eezF-1r0lA:0.05eezG-1r0lA:undetectable | 5eezF-1r0lA:11.765eezG-1r0lA:11.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rp0 | THIAZOLEBIOSYNTHETIC ENZYME (Arabidopsisthaliana) |
PF01946(Thi4) | 5 | THR A 239ALA A 54GLY A 46ALA A 55ILE A 68 | NoneNoneAHZ A 600 (-3.1A)NoneNone | 1.09A | 5eezF-1rp0A:undetectable5eezG-1rp0A:undetectable | 5eezF-1rp0A:14.985eezG-1rp0A:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sch | PEANUT PEROXIDASE,MAJOR CATIONICISOZYME (Arachishypogaea) |
PF00141(peroxidase) | 5 | ALA A 105GLY A 76ALA A 104HIS A 42ILE A 80 | None | 1.19A | 5eezF-1schA:undetectable5eezG-1schA:undetectable | 5eezF-1schA:15.075eezG-1schA:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9c | PRECORRIN-8X METHYLMUTASE (Thermusthermophilus) |
PF02570(CbiC) | 5 | THR A 40GLY A 188ALA A 196THR A 49THR A 183 | None | 1.16A | 5eezF-1v9cA:0.05eezG-1v9cA:undetectable | 5eezF-1v9cA:19.255eezG-1v9cA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y6j | L-LACTATEDEHYDROGENASE (Ruminiclostridiumthermocellum) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ALA A 239GLY A 14ALA A 22THR A 81ILE A 12 | None | 1.10A | 5eezF-1y6jA:undetectable5eezG-1y6jA:undetectable | 5eezF-1y6jA:15.485eezG-1y6jA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yy5 | FMS1 PROTEIN (Saccharomycescerevisiae) |
PF01593(Amino_oxidase) | 5 | SER A 495GLY A 15ALA A 23THR A 252ILE A 13 | NoneFAD A 803 (-3.2A)NoneFAD A 803 (-4.6A)None | 0.97A | 5eezF-1yy5A:undetectable5eezG-1yy5A:undetectable | 5eezF-1yy5A:9.735eezG-1yy5A:9.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2afb | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermotogamaritima) |
PF00294(PfkB) | 5 | ALA A 40GLY A 33THR A 5HIS A 131ILE A 9 | None | 1.19A | 5eezF-2afbA:undetectable5eezG-2afbA:undetectable | 5eezF-2afbA:13.245eezG-2afbA:13.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw4 | LYSINE-SPECIFICHISTONE DEMETHYLASE1 (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 5 | ALA A 292GLY A 285ALA A 293THR A 624ILE A 283 | NoneFAD A1001 (-3.2A)NoneFAD A1001 (-4.9A)None | 1.08A | 5eezF-2dw4A:undetectable5eezG-2dw4A:undetectable | 5eezF-2dw4A:8.155eezG-2dw4A:8.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw4 | LYSINE-SPECIFICHISTONE DEMETHYLASE1 (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 5 | SER A 817GLY A 285ALA A 293THR A 624ILE A 283 | NoneFAD A1001 (-3.2A)NoneFAD A1001 (-4.9A)None | 0.89A | 5eezF-2dw4A:undetectable5eezG-2dw4A:undetectable | 5eezF-2dw4A:8.155eezG-2dw4A:8.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fff | PENICILLIN-BINDINGPROTEIN 1B (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 5 | GLY B 677ALA B 688THR B 417HIS B 682ILE B 676 | NoneNoneNone NI B 901 (-2.8A)None | 1.03A | 5eezF-2fffB:undetectable5eezG-2fffB:undetectable | 5eezF-2fffB:11.035eezG-2fffB:11.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hlp | MALATE DEHYDROGENASE (Haloarculamarismortui) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ALA A 251GLY A 28ALA A 36THR A 138THR A 97 | None | 1.15A | 5eezF-2hlpA:undetectable5eezG-2hlpA:undetectable | 5eezF-2hlpA:14.625eezG-2hlpA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nrh | TRANSCRIPTIONALACTIVATOR, PUTATIVE,BAF FAMILY (Campylobacterjejuni) |
PF03309(Pan_kinase) | 5 | THR A 95ALA A 78GLY A 72ALA A 77ILE A 73 | None | 1.06A | 5eezF-2nrhA:undetectable5eezG-2nrhA:undetectable | 5eezF-2nrhA:18.145eezG-2nrhA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nzu | CATABOLITE CONTROLPROTEIN (Bacillusmegaterium) |
PF13377(Peripla_BP_3) | 5 | SER G 147ALA G 146ALA G 145HIS G 131ILE G 121 | None | 1.17A | 5eezF-2nzuG:undetectable5eezG-2nzuG:undetectable | 5eezF-2nzuG:15.105eezG-2nzuG:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o2c | GLUCOSE-6-PHOSPHATEISOMERASE,GLYCOSOMAL (Trypanosomabrucei) |
PF00342(PGI) | 5 | ALA A 276ALA A 273THR A 252HIS A 199ILE A 203 | None | 1.08A | 5eezF-2o2cA:undetectable5eezG-2o2cA:undetectable | 5eezF-2o2cA:9.575eezG-2o2cA:9.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oxt | NUCLEOSIDE-2'-O-METHYLTRANSFERASE (Meaban virus) |
PF01728(FtsJ) | 5 | SER A 94ALA A 93GLY A 87ALA A 92THR A 60 | NoneNoneSAM A 300 (-3.2A)NoneNone | 1.17A | 5eezF-2oxtA:undetectable5eezG-2oxtA:undetectable | 5eezF-2oxtA:11.765eezG-2oxtA:11.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pan | GLYOXYLATECARBOLIGASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | THR A 391ALA A 400GLY A 394ALA A 399THR A 259 | NoneNoneTDP A 801 (-3.6A)NoneFAD A 701 (-3.2A) | 1.11A | 5eezF-2panA:undetectable5eezG-2panA:undetectable | 5eezF-2panA:9.745eezG-2panA:9.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qt3 | N-ISOPROPYLAMMELIDEISOPROPYLAMIDOHYDROLASE (Pseudomonas sp.ADP) |
PF01979(Amidohydro_1) | 5 | ALA A 111THR A 61HIS A 62THR A 124ILE A 153 | NoneNone ZN A 501 (-3.3A)NoneNone | 1.13A | 5eezF-2qt3A:undetectable5eezG-2qt3A:undetectable | 5eezF-2qt3A:14.295eezG-2qt3A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aex | THREONINE SYNTHASE (Thermusthermophilus) |
PF00291(PALP) | 5 | ALA A 293GLY A 187ALA A 292THR A 317ILE A 241 | NoneAN7 A1001 (-3.5A)NoneAN7 A1001 (-2.8A)AN7 A1001 (-4.7A) | 1.06A | 5eezF-3aexA:undetectable5eezG-3aexA:undetectable | 5eezF-3aexA:11.365eezG-3aexA:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9g | IAG-NUCLEOSIDEHYDROLASE (Trypanosomavivax) |
PF01156(IU_nuc_hydro) | 5 | THR A 295GLY A 166ALA A 194THR A 284ILE A 187 | None | 1.03A | 5eezF-3b9gA:undetectable5eezG-3b9gA:undetectable | 5eezF-3b9gA:13.115eezG-3b9gA:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bga | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 5 | SER A 448ALA A 450GLY A 482HIS A 440ILE A 437 | NoneNoneNone MG A 1 (-3.3A)None | 1.15A | 5eezF-3bgaA:undetectable5eezG-3bgaA:1.6 | 5eezF-3bgaA:5.555eezG-3bgaA:5.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3byw | PUTATIVEARABINOFURANOSYLTRANSFERASE (Corynebacteriumdiphtheriae) |
PF04602(Arabinose_trans) | 5 | ALA A 67GLY A 86ALA A 188THR A 87ILE A 169 | None | 1.17A | 5eezF-3bywA:undetectable5eezG-3bywA:undetectable | 5eezF-3bywA:22.455eezG-3bywA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cb5 | FACT COMPLEX SUBUNITSPT16 (Schizosaccharomycespombe) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 5 | SER A 191ALA A 187THR A 426THR A 414ILE A 184 | None | 0.95A | 5eezF-3cb5A:undetectable5eezG-3cb5A:undetectable | 5eezF-3cb5A:9.955eezG-3cb5A:9.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csk | PROBABLEDIPEPTIDYL-PEPTIDASE3 (Saccharomycescerevisiae) |
PF03571(Peptidase_M49) | 5 | ALA A 42GLY A 322ALA A 39THR A 391ILE A 321 | None | 1.13A | 5eezF-3cskA:undetectable5eezG-3cskA:undetectable | 5eezF-3cskA:7.055eezG-3cskA:7.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dec | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 5 | SER A 424ALA A 426GLY A 458HIS A 416ILE A 413 | None | 1.13A | 5eezF-3decA:0.05eezG-3decA:0.0 | 5eezF-3decA:5.715eezG-3decA:5.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fao | NON-STRUCTURALPROTEIN (Porcinereproductiveand respiratorysyndrome virus) |
PF05579(Peptidase_S32) | 5 | ALA A 38GLY A 149ALA A 66THR A 134THR A 145 | None | 1.18A | 5eezF-3faoA:undetectable5eezG-3faoA:undetectable | 5eezF-3faoA:18.445eezG-3faoA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdi | UNCHARACTERIZEDPROTEIN (Eubacteriumventriosum) |
PF13189(Cytidylate_kin2) | 5 | ALA A 24GLY A 16HIS A 17THR A 186ILE A 8 | NoneSO4 A2003 (-3.6A)NoneNoneNone | 0.99A | 5eezF-3fdiA:undetectable5eezG-3fdiA:undetectable | 5eezF-3fdiA:22.445eezG-3fdiA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpa | AMIDOHYDROLASE (unidentified) |
PF01979(Amidohydro_1) | 5 | THR A 442GLY A 174ALA A 140THR A 457ILE A 173 | None | 1.19A | 5eezF-3hpaA:undetectable5eezG-3hpaA:undetectable | 5eezF-3hpaA:10.655eezG-3hpaA:10.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6d | PROTOPORPHYRINOGENOXIDASE (Bacillussubtilis) |
PF01593(Amino_oxidase) | 5 | ALA A 19GLY A 12ALA A 20THR A 284ILE A 10 | NoneFAD A 600 (-3.4A)NoneNoneNone | 1.06A | 5eezF-3i6dA:undetectable5eezG-3i6dA:undetectable | 5eezF-3i6dA:14.255eezG-3i6dA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jsk | CYPBP37 PROTEIN (Neurosporacrassa) |
PF01946(Thi4) | 5 | SER A 322GLY A 86ALA A 94THR A 246ILE A 84 | NoneAHZ A 500 (-3.0A)NoneNoneNone | 1.13A | 5eezF-3jskA:undetectable5eezG-3jskA:undetectable | 5eezF-3jskA:13.375eezG-3jskA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kto | RESPONSE REGULATORRECEIVER PROTEIN (Pseudoalteromonasatlantica) |
PF00072(Response_reg) | 5 | SER A 107ALA A 106GLY A 72ALA A 103THR A 88 | None | 1.13A | 5eezF-3ktoA:undetectable5eezG-3ktoA:undetectable | 5eezF-3ktoA:18.945eezG-3ktoA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nix | FLAVOPROTEIN/DEHYDROGENASE (Cytophagahutchinsonii) |
PF01494(FAD_binding_3) | 5 | THR A 293ALA A 20GLY A 12ALA A 21ILE A 33 | NoneNoneFAD A 501 (-3.2A)NoneNone | 0.99A | 5eezF-3nixA:undetectable5eezG-3nixA:undetectable | 5eezF-3nixA:11.115eezG-3nixA:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3on3 | KETO/OXOACIDFERREDOXINOXIDOREDUCTASE,GAMMA SUBUNIT (Geobactersulfurreducens) |
PF01558(POR) | 5 | SER A 29ALA A 28GLY A 21ALA A 27ILE A 23 | None | 1.00A | 5eezF-3on3A:undetectable5eezG-3on3A:undetectable | 5eezF-3on3A:15.685eezG-3on3A:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ot5 | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Listeriamonocytogenes) |
PF02350(Epimerase_2) | 5 | ALA A 105GLY A 11ALA A 106THR A 40ILE A 9 | None | 1.06A | 5eezF-3ot5A:undetectable5eezG-3ot5A:undetectable | 5eezF-3ot5A:13.225eezG-3ot5A:13.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qj4 | RENALASE (Homo sapiens) |
PF01593(Amino_oxidase)PF13450(NAD_binding_8) | 5 | SER A 330ALA A 331GLY A 8THR A 160ILE A 6 | NoneNoneFAD A 401 (-3.3A)NoneNone | 1.18A | 5eezF-3qj4A:undetectable5eezG-3qj4A:undetectable | 5eezF-3qj4A:12.685eezG-3qj4A:12.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swx | PROBABLE ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteroidesabscessus) |
PF00378(ECH_1) | 5 | ALA A 120GLY A 178ALA A 117THR A 153ILE A 179 | None | 1.13A | 5eezF-3swxA:undetectable5eezG-3swxA:undetectable | 5eezF-3swxA:14.725eezG-3swxA:14.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tm9 | BACTERIAL HEMOGLOBIN (Vitreoscillastercoraria) |
PF00042(Globin) | 5 | ALA A 113HIS A 20ALA A 114THR A 13ILE A 106 | None | 1.13A | 5eezF-3tm9A:undetectable5eezG-3tm9A:undetectable | 5eezF-3tm9A:22.705eezG-3tm9A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tpc | SHORT CHAIN ALCOHOLDEHYDROGENASE-RELATED DEHYDROGENASE (Sinorhizobiummeliloti) |
PF00106(adh_short) | 5 | ALA A 127GLY A 143ALA A 128HIS A 81ILE A 186 | None | 1.10A | 5eezF-3tpcA:undetectable5eezG-3tpcA:undetectable | 5eezF-3tpcA:15.085eezG-3tpcA:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w5n | PUTATIVERHAMNOSIDASE (Streptomycesavermitilis) |
PF05592(Bac_rhamnosid)PF08531(Bac_rhamnosid_N)PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 5 | ALA A 546GLY A 569HIS A 568ALA A 545THR A 539 | None | 1.16A | 5eezF-3w5nA:2.05eezG-3w5nA:2.0 | 5eezF-3w5nA:5.725eezG-3w5nA:5.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wpe | TOLL-LIKE RECEPTOR 9 (Bos taurus) |
PF13516(LRR_6)PF13855(LRR_8) | 5 | SER A 148GLY A 133HIS A 151THR A 152ILE A 134 | None | 1.19A | 5eezF-3wpeA:undetectable5eezG-3wpeA:undetectable | 5eezF-3wpeA:7.175eezG-3wpeA:7.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zte | TRYPTOPHAN OPERONRNA-BINDINGATTENUATION PROTEIN(TRAP) (Bacilluslicheniformis) |
PF02081(TrpBP) | 6 | GLY A 23HIS A 34THR A 49HIS A 51THR A 52ILE A 55 | TRP A 80 (-3.5A)TRP A 80 ( 4.9A)TRP A 80 (-2.8A)NoneTRP A 80 (-3.6A)TRP A 80 ( 4.6A) | 0.25A | 5eezF-3zteA:14.85eezG-3zteA:14.6 | 5eezF-3zteA:78.215eezG-3zteA:78.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zzl | TRANSCRIPTIONATTENUATION PROTEINMTRB (Bacillushalodurans) |
PF02081(TrpBP) | 6 | ALA A 46GLY A 23HIS A 34THR A 49HIS A 51THR A 52 | TRP A 81 ( 3.7A)TRP A 81 (-3.5A)TRP A 81 ( 4.7A)TRP A 81 ( 2.9A)NoneTRP A 81 (-3.7A) | 0.94A | 5eezF-3zzlA:13.25eezG-3zzlA:13.4 | 5eezF-3zzlA:71.435eezG-3zzlA:71.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zzl | TRANSCRIPTIONATTENUATION PROTEINMTRB (Bacillushalodurans) |
PF02081(TrpBP) | 6 | GLY A 23HIS A 34ALA A 46THR A 49HIS A 51THR A 52 | TRP A 81 (-3.5A)TRP A 81 ( 4.7A)TRP A 81 ( 3.7A)TRP A 81 ( 2.9A)NoneTRP A 81 (-3.7A) | 0.28A | 5eezF-3zzlA:13.25eezG-3zzlA:13.4 | 5eezF-3zzlA:71.435eezG-3zzlA:71.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zzq | TRANSCRIPTIONATTENUATION PROTEINMTRB (Bacillussubtilis) |
PF02081(TrpBP) | 5 | ALA A 46GLY A 23HIS A 34THR A 49THR A 52 | TRP A 81 ( 3.7A)TRP A 81 (-3.4A)TRP A 81 ( 4.9A)TRP A 81 ( 2.9A)TRP A 81 (-3.8A) | 1.05A | 5eezF-3zzqA:13.75eezG-3zzqA:13.9 | 5eezF-3zzqA:80.005eezG-3zzqA:80.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zzq | TRANSCRIPTIONATTENUATION PROTEINMTRB (Bacillussubtilis) |
PF02081(TrpBP) | 6 | GLY A 23HIS A 34ALA A 46THR A 49THR A 52ILE A 55 | TRP A 81 (-3.4A)TRP A 81 ( 4.9A)TRP A 81 ( 3.7A)TRP A 81 ( 2.9A)TRP A 81 (-3.8A)TRP A 81 ( 4.4A) | 0.13A | 5eezF-3zzqA:13.75eezG-3zzqA:13.9 | 5eezF-3zzqA:80.005eezG-3zzqA:80.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zzs | TRANSCRIPTIONATTENUATION PROTEINMTRB (Geobacillusstearothermophilus) |
PF02081(TrpBP) | 6 | ALA A 46GLY A 23HIS A 34THR A 49HIS A 51THR A 52 | TRP A1072 ( 3.8A)TRP A1072 (-3.5A)TRP A1072 ( 4.7A)TRP A1072 (-2.9A)NoneTRP A1072 (-3.8A) | 1.08A | 5eezF-3zzsA:13.75eezG-3zzsA:13.8 | 5eezF-3zzsA:100.005eezG-3zzsA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zzs | TRANSCRIPTIONATTENUATION PROTEINMTRB (Geobacillusstearothermophilus) |
PF02081(TrpBP) | 7 | GLY A 23HIS A 34ALA A 46THR A 49HIS A 51THR A 52ILE A 55 | TRP A1072 (-3.5A)TRP A1072 ( 4.7A)TRP A1072 ( 3.8A)TRP A1072 (-2.9A)NoneTRP A1072 (-3.8A)TRP A1072 ( 4.4A) | 0.14A | 5eezF-3zzsA:13.75eezG-3zzsA:13.8 | 5eezF-3zzsA:100.005eezG-3zzsA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4b27 | TRANSCRIPTIONATTENUATION PROTEINMTRB (Bacillussubtilis) |
PF02081(TrpBP) | 6 | ALA A 46GLY A 23HIS A 34THR A 49HIS A 51THR A 52 | ALA A 46 ( 0.0A)GLY A 23 (-0.0A)HIS A 34 ( 1.0A)THR A 49 (-0.8A)HIS A 51 ( 1.0A)THR A 52 (-0.8A) | 1.12A | 5eezF-4b27A:13.35eezG-4b27A:13.4 | 5eezF-4b27A:76.325eezG-4b27A:76.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4b27 | TRANSCRIPTIONATTENUATION PROTEINMTRB (Bacillussubtilis) |
PF02081(TrpBP) | 7 | GLY A 23HIS A 34ALA A 46THR A 49HIS A 51THR A 52ILE A 55 | GLY A 23 (-0.0A)HIS A 34 ( 1.0A)ALA A 46 ( 0.0A)THR A 49 (-0.8A)HIS A 51 ( 1.0A)THR A 52 (-0.8A)ILE A 55 ( 0.6A) | 0.23A | 5eezF-4b27A:13.35eezG-4b27A:13.4 | 5eezF-4b27A:76.325eezG-4b27A:76.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bx9 | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 33A (Homo sapiens) |
PF00995(Sec1) | 5 | SER A 504ALA A 500THR A 572THR A 545ILE A 547 | None | 1.10A | 5eezF-4bx9A:undetectable5eezG-4bx9A:undetectable | 5eezF-4bx9A:7.915eezG-4bx9A:7.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cta | CINA-LIKE PROTEIN (Thermusthermophilus) |
PF00994(MoCF_biosynth)PF02464(CinA) | 5 | THR A 271ALA A 388GLY A 276THR A 266ILE A 279 | None | 1.08A | 5eezF-4ctaA:undetectable5eezG-4ctaA:undetectable | 5eezF-4ctaA:12.965eezG-4ctaA:12.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ebj | AMINOGLYCOSIDENUCLEOTIDYLTRANSFERASE (Pseudomonasaeruginosa) |
PF01909(NTP_transf_2) | 5 | ALA A 174GLY A 90ALA A 177THR A 93HIS A 118 | SO4 A 303 (-3.6A)NoneNoneNoneNone | 1.16A | 5eezF-4ebjA:undetectable5eezG-4ebjA:undetectable | 5eezF-4ebjA:14.715eezG-4ebjA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ga6 | PUTATIVE THYMIDINEPHOSPHORYLASE (Thermococcuskodakarensis) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 5 | ALA A 334ALA A 331THR A 327HIS A 326ILE A 410 | NoneNoneNoneSO4 A 603 (-3.7A)None | 1.13A | 5eezF-4ga6A:undetectable5eezG-4ga6A:undetectable | 5eezF-4ga6A:13.335eezG-4ga6A:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvl | TRKA DOMAIN PROTEIN (Geobactersulfurreducens) |
PF02080(TrkA_C)PF02254(TrkA_N) | 5 | ALA A 365GLY A 358ALA A 366THR A 418ILE A 356 | NoneAMP A 602 (-3.6A)NoneNoneNone | 1.12A | 5eezF-4gvlA:undetectable5eezG-4gvlA:undetectable | 5eezF-4gvlA:10.475eezG-4gvlA:10.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvl | TRKA DOMAIN PROTEIN (Geobactersulfurreducens) |
PF02080(TrkA_C)PF02254(TrkA_N) | 5 | ALA A 365HIS A 359ALA A 366THR A 418ILE A 416 | None ZN A 601 (-3.4A)NoneNoneNone | 1.08A | 5eezF-4gvlA:undetectable5eezG-4gvlA:undetectable | 5eezF-4gvlA:10.475eezG-4gvlA:10.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gx0 | TRKA DOMAIN PROTEIN (Geobactersulfurreducens) |
PF02080(TrkA_C)PF02254(TrkA_N)PF07885(Ion_trans_2) | 5 | ALA A 365GLY A 358ALA A 366THR A 418ILE A 356 | None | 1.11A | 5eezF-4gx0A:undetectable5eezG-4gx0A:undetectable | 5eezF-4gx0A:8.705eezG-4gx0A:8.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gx0 | TRKA DOMAIN PROTEIN (Geobactersulfurreducens) |
PF02080(TrkA_C)PF02254(TrkA_N)PF07885(Ion_trans_2) | 5 | ALA A 365HIS A 359ALA A 366THR A 418ILE A 416 | None ZN A 606 (-3.5A)NoneNoneNone | 1.15A | 5eezF-4gx0A:undetectable5eezG-4gx0A:undetectable | 5eezF-4gx0A:8.705eezG-4gx0A:8.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6x | THIAZOLINEOXIDASE/SUBTILISIN-LIKE PROTEASE (Prochlorondidemni) |
PF00082(Peptidase_S8) | 5 | ALA A 786HIS A 618ALA A 785THR A 625ILE A 766 | None | 1.10A | 5eezF-4h6xA:undetectable5eezG-4h6xA:undetectable | 5eezF-4h6xA:13.065eezG-4h6xA:13.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hsu | LYSINE-SPECIFICHISTONE DEMETHYLASE1B (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM)PF07496(zf-CW) | 5 | SER A 811GLY A 389ALA A 397THR A 626ILE A 387 | NoneFAD A 901 (-3.3A)NoneNoneNone | 0.94A | 5eezF-4hsuA:undetectable5eezG-4hsuA:undetectable | 5eezF-4hsuA:7.645eezG-4hsuA:7.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4n | INTRACELLULARPROTEASE/AMIDASE (Vibrio cholerae) |
no annotation | 5 | ALA A 58GLY A 190THR A 80HIS A 76ILE A 154 | None | 1.11A | 5eezF-4i4nA:undetectable5eezG-4i4nA:undetectable | 5eezF-4i4nA:12.105eezG-4i4nA:12.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpr | THIOREDOXINREDUCTASE 1,CYTOPLASMIC (Rattusnorvegicus) |
no annotation | 5 | GLY E 470HIS E 472THR E 481THR E 480ILE E 469 | None | 1.19A | 5eezF-4kprE:undetectable5eezG-4kprE:undetectable | 5eezF-4kprE:9.645eezG-4kprE:9.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lx4 | ENDOGLUCANASE(ENDO-1,4-BETA-GLUCANASE)PROTEIN (Pseudomonasstutzeri) |
PF00150(Cellulase) | 5 | THR A 148ALA A 155GLY A 176ALA A 156ILE A 174 | None | 0.93A | 5eezF-4lx4A:undetectable5eezG-4lx4A:undetectable | 5eezF-4lx4A:13.425eezG-4lx4A:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lz6 | BH2163 PROTEIN (Bacillushalodurans) |
PF01554(MatE) | 5 | SER A 271GLY A 55THR A 129THR A 132ILE A 58 | None | 1.10A | 5eezF-4lz6A:undetectable5eezG-4lz6A:undetectable | 5eezF-4lz6A:11.375eezG-4lz6A:11.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov4 | 2-ISOPROPYLMALATESYNTHASE (Leptospirabiflexa) |
PF00682(HMGL-like) | 5 | SER A 219GLY A 213ALA A 217THR A 244HIS A 209 | NoneNoneNoneNone ZN A 401 ( 3.4A) | 1.11A | 5eezF-4ov4A:undetectable5eezG-4ov4A:undetectable | 5eezF-4ov4A:11.115eezG-4ov4A:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qgs | ALCOHOLDEHYDROGENASE YQHD (Escherichiacoli) |
PF00465(Fe-ADH) | 5 | SER A 129ALA A 130GLY A 124ALA A 106ILE A 119 | None | 1.12A | 5eezF-4qgsA:undetectable5eezG-4qgsA:undetectable | 5eezF-4qgsA:11.895eezG-4qgsA:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qn8 | VIPE (Legionellapneumophila) |
no annotation | 5 | ALA A 107GLY A 68HIS A 112ALA A 104THR A 80 | None | 1.10A | 5eezF-4qn8A:undetectable5eezG-4qn8A:undetectable | 5eezF-4qn8A:18.125eezG-4qn8A:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4umv | ZINC-TRANSPORTINGATPASE (Shigella sonnei) |
PF00122(E1-E2_ATPase)PF00702(Hydrolase) | 5 | ALA A 589GLY A 289ALA A 590THR A 442THR A 438 | NoneBEF A1732 (-3.0A)NoneNoneBEF A1732 ( 3.7A) | 1.04A | 5eezF-4umvA:undetectable5eezG-4umvA:undetectable | 5eezF-4umvA:7.075eezG-4umvA:7.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4usc | PEROXIDASE (Trachycarpusfortunei) |
PF00141(peroxidase) | 5 | ALA A 105GLY A 76ALA A 104HIS A 42ILE A 80 | NoneSO4 A1316 (-3.9A)NonePEO A1320 (-3.6A)None | 1.17A | 5eezF-4uscA:undetectable5eezG-4uscA:undetectable | 5eezF-4uscA:13.015eezG-4uscA:13.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yhs | MONOSACCHARIDE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN, CUT2 FAMILY (Bradyrhizobiumsp. BTAi1) |
PF13407(Peripla_BP_4) | 5 | ALA A 274GLY A 284ALA A 293THR A 278ILE A 285 | None | 1.03A | 5eezF-4yhsA:undetectable5eezG-4yhsA:undetectable | 5eezF-4yhsA:14.025eezG-4yhsA:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ztb | PROTEASE NSP2 (Chikungunyavirus) |
PF01707(Peptidase_C9) | 5 | ALA A 280HIS A 140HIS A 309THR A 308ILE A 268 | None | 1.03A | 5eezF-4ztbA:undetectable5eezG-4ztbA:undetectable | 5eezF-4ztbA:14.605eezG-4ztbA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ay9 | 4-O-BETA-D-MANNOSYL-D-GLUCOSEPHOSPHORYLASE (Ruminococcusalbus) |
PF04041(Glyco_hydro_130) | 5 | ALA A 74GLY A 255ALA A 325THR A 322ILE A 268 | None | 1.18A | 5eezF-5ay9A:undetectable5eezG-5ay9A:undetectable | 5eezF-5ay9A:12.605eezG-5ay9A:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dgq | PUTATIVEENDOGLUCANASE-RELATED PROTEIN (Photobacteriumprofundum) |
PF00759(Glyco_hydro_9) | 5 | ALA A 244GLY A 290HIS A 293ALA A 250ILE A 254 | None | 1.07A | 5eezF-5dgqA:undetectable5eezG-5dgqA:undetectable | 5eezF-5dgqA:8.275eezG-5dgqA:8.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eex | TRANSCRIPTIONATTENUATION PROTEINMTRB (Geobacillusstearothermophilus) |
PF02081(TrpBP) | 6 | ALA A 46GLY A 23HIS A 34THR A 49HIS A 51THR A 52 | None | 1.09A | 5eezF-5eexA:15.45eezG-5eexA:15.9 | 5eezF-5eexA:100.005eezG-5eexA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eex | TRANSCRIPTIONATTENUATION PROTEINMTRB (Geobacillusstearothermophilus) |
PF02081(TrpBP) | 7 | GLY A 23HIS A 34ALA A 46THR A 49HIS A 51THR A 52ILE A 55 | None | 0.13A | 5eezF-5eexA:15.45eezG-5eexA:15.9 | 5eezF-5eexA:100.005eezG-5eexA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eso | 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATE SYNTHASE (Mycobacteriumtuberculosis) |
PF02776(TPP_enzyme_N) | 5 | THR A 250ALA A 376HIS A 232ALA A 402THR A 279 | None | 1.02A | 5eezF-5esoA:undetectable5eezG-5esoA:undetectable | 5eezF-5esoA:7.885eezG-5esoA:7.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ggg | PROTEINO-LINKED-MANNOSEBETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE1 (Homo sapiens) |
PF03071(GNT-I)PF15711(ILEI) | 5 | ALA A 189GLY A 181HIS A 184THR A 151ILE A 131 | None | 1.02A | 5eezF-5gggA:undetectable5eezG-5gggA:undetectable | 5eezF-5gggA:8.925eezG-5gggA:8.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ggk | PROTEINO-LINKED-MANNOSEBETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE1 (Homo sapiens) |
PF15711(ILEI) | 5 | ALA A 189GLY A 181HIS A 184THR A 151ILE A 131 | None | 1.06A | 5eezF-5ggkA:1.45eezG-5ggkA:undetectable | 5eezF-5ggkA:23.235eezG-5ggkA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hpn | PERMUTED PDUA (syntheticconstruct) |
PF00936(BMC) | 5 | SER A 48ALA A 49GLY A 28ALA A 74THR A 79 | None | 1.13A | 5eezF-5hpnA:undetectable5eezG-5hpnA:undetectable | 5eezF-5hpnA:23.165eezG-5hpnA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j84 | DIHYDROXY-ACIDDEHYDRATASE (Rhizobiumleguminosarum) |
PF00920(ILVD_EDD) | 5 | THR A 377SER A 315ALA A 400GLY A 381ILE A 382 | None | 1.10A | 5eezF-5j84A:undetectable5eezG-5j84A:undetectable | 5eezF-5j84A:8.035eezG-5j84A:8.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jn6 | UNCHARACTERIZEDPROTEIN (Rhodopseudomonaspalustris) |
no annotation | 5 | ALA A 36GLY A 16ALA A 37HIS A 49ILE A 17 | None | 1.17A | 5eezF-5jn6A:undetectable5eezG-5jn6A:undetectable | 5eezF-5jn6A:24.185eezG-5jn6A:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kgn | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Caenorhabditiselegans) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | THR A 206ALA A 226GLY A 139ALA A 213HIS A 136 | None | 1.19A | 5eezF-5kgnA:undetectable5eezG-5kgnA:undetectable | 5eezF-5kgnA:11.005eezG-5kgnA:11.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ks1 | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Vibriovulnificus) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | THR A 283ALA A 123ALA A 100THR A 17ILE A 6 | None | 1.18A | 5eezF-5ks1A:undetectable5eezG-5ks1A:undetectable | 5eezF-5ks1A:9.955eezG-5ks1A:9.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3d | LYSINE-SPECIFICHISTONE DEMETHYLASE1A (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 5 | ALA A 292GLY A 285ALA A 293THR A 624ILE A 283 | NoneFAD A 901 (-3.3A)NoneNoneNone | 1.09A | 5eezF-5l3dA:undetectable5eezG-5l3dA:undetectable | 5eezF-5l3dA:6.275eezG-5l3dA:6.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3d | LYSINE-SPECIFICHISTONE DEMETHYLASE1A (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 5 | SER A 817GLY A 285ALA A 293THR A 624ILE A 283 | NoneFAD A 901 (-3.3A)NoneNoneNone | 0.92A | 5eezF-5l3dA:undetectable5eezG-5l3dA:undetectable | 5eezF-5l3dA:6.275eezG-5l3dA:6.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lgc | ARCE4A (Arthrobactersp. AW19M34-1) |
PF01522(Polysacc_deac_1) | 5 | GLY A 80THR A 199HIS A 77THR A 54ILE A 118 | None | 1.06A | 5eezF-5lgcA:undetectable5eezG-5lgcA:undetectable | 5eezF-5lgcA:17.895eezG-5lgcA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o1m | RUBBER OXYGENASE (Streptomycessp. K30) |
PF09995(DUF2236) | 5 | SER A 186GLY A 172ALA A 180THR A 190ILE A 175 | None | 1.16A | 5eezF-5o1mA:undetectable5eezG-5o1mA:undetectable | 5eezF-5o1mA:12.645eezG-5o1mA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sy4 | CHAPERONE YAJL (Escherichiacoli) |
PF01965(DJ-1_PfpI) | 5 | ALA A 104GLY A 165ALA A 103THR A 21ILE A 168 | None | 0.97A | 5eezF-5sy4A:undetectable5eezG-5sy4A:undetectable | 5eezF-5sy4A:17.625eezG-5sy4A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5twt | PEROXIDASE PVI9 (Panicumvirgatum) |
PF00141(peroxidase) | 5 | ALA A 103GLY A 74ALA A 102HIS A 42ILE A 78 | NoneSO4 A 304 (-3.5A)NoneNoneNone | 1.16A | 5eezF-5twtA:undetectable5eezG-5twtA:undetectable | 5eezF-5twtA:11.015eezG-5twtA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux5 | BIFUNCTIONAL PROTEINPROLINE UTILIZATIONA (PUTA) (Corynebacteriumfreiburgense) |
PF00171(Aldedh)PF01619(Pro_dh) | 5 | SER A 724ALA A 725GLY A 874ALA A 726THR A 846 | SO4 A2003 (-2.4A)NoneNoneNoneNone | 1.18A | 5eezF-5ux5A:undetectable5eezG-5ux5A:undetectable | 5eezF-5ux5A:5.765eezG-5ux5A:5.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux5 | BIFUNCTIONAL PROTEINPROLINE UTILIZATIONA (PUTA) (Corynebacteriumfreiburgense) |
PF00171(Aldedh)PF01619(Pro_dh) | 5 | SER A 724GLY A 874ALA A 726THR A 846ILE A 696 | SO4 A2003 (-2.4A)NoneNoneNoneNone | 1.19A | 5eezF-5ux5A:undetectable5eezG-5ux5A:undetectable | 5eezF-5ux5A:5.765eezG-5ux5A:5.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0s | 60 KDA CHAPERONIN (Escherichiacoli) |
PF00118(Cpn60_TCP1) | 5 | ALA A 165GLY A 148HIS A 401THR A 403ILE A 144 | None | 1.18A | 5eezF-5w0sA:undetectable5eezG-5w0sA:undetectable | 5eezF-5w0sA:10.235eezG-5w0sA:10.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6r | GENOME POLYPROTEIN (Pestivirus C) |
no annotation | 5 | GLY A 147ALA A 622HIS A 626THR A 627ILE A 148 | SO4 A 706 ( 4.4A)NoneSO4 A 706 (-3.9A)NoneNone | 1.19A | 5eezF-5y6rA:undetectable5eezG-5y6rA:undetectable | 5eezF-5y6rA:undetectable5eezG-5y6rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ygr | DIAMINOPROPIONATEAMMONIA LYASE (Salmonellaenterica) |
no annotation | 5 | GLY A 126ALA A 133THR A 122THR A 124ILE A 159 | PO4 A 504 (-4.5A)NoneNonePO4 A 504 (-3.6A)None | 1.01A | 5eezF-5ygrA:undetectable5eezG-5ygrA:undetectable | 5eezF-5ygrA:undetectable5eezG-5ygrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zln | TOLL-LIKE RECEPTOR 9 (Mus musculus) |
no annotation | 5 | SER A 149GLY A 134HIS A 152THR A 153ILE A 135 | None | 1.14A | 5eezF-5zlnA:undetectable5eezG-5zlnA:undetectable | 5eezF-5zlnA:undetectable5eezG-5zlnA:undetectable |