SIMILAR PATTERNS OF AMINO ACIDS FOR 5EEX_V_TRPV101
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 5 | GLY A 412ALA A 510THR A 500THR A 417SER A 245 | NoneNoneNoneTRA A 866 (-4.0A)TRA A 866 (-2.6A) | 1.07A | 5eexU-1l5jA:0.05eexV-1l5jA:undetectable | 5eexU-1l5jA:7.075eexV-1l5jA:7.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lzx | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF02898(NO_synthase) | 5 | THR A 688HIS A 652THR A 655ILE A 679THR A 591 | None | 1.36A | 5eexU-1lzxA:undetectable5eexV-1lzxA:undetectable | 5eexU-1lzxA:10.025eexV-1lzxA:10.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m9q | ENDOTHELIALNITRIC-OXIDESYNTHASE (Homo sapiens) |
PF02898(NO_synthase) | 5 | THR A 457HIS A 421THR A 424ILE A 448THR A 360 | None | 1.35A | 5eexU-1m9qA:0.05eexV-1m9qA:0.0 | 5eexU-1m9qA:9.885eexV-1m9qA:9.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mio | NITROGENASEMOLYBDENUM IRONPROTEIN (BETA CHAIN) (Clostridiumpasteurianum) |
PF00148(Oxidored_nitro) | 5 | GLY B 156ALA B 151THR B 139HIS B 103THR B 137 | None | 1.31A | 5eexU-1mioB:undetectable5eexV-1mioB:0.0 | 5eexU-1mioB:9.765eexV-1mioB:9.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n0w | DNA REPAIR PROTEINRAD51 HOMOLOG 1 (Homo sapiens) |
PF08423(Rad51) | 5 | GLY A 116ALA A 262THR A 123ILE A 102SER A 121 | MG A 401 (-3.8A)NoneNoneNoneNone | 1.26A | 5eexU-1n0wA:0.05eexV-1n0wA:0.0 | 5eexU-1n0wA:14.405eexV-1n0wA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ps9 | 2,4-DIENOYL-COAREDUCTASE (Escherichiacoli) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 5 | GLY A 248THR A 272THR A 247ILE A 249THR A 230 | None | 1.38A | 5eexU-1ps9A:undetectable5eexV-1ps9A:undetectable | 5eexU-1ps9A:8.105eexV-1ps9A:8.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8f | PYRIMIDINENUCLEOSIDE HYDROLASE (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 5 | GLY A 152ALA A 174THR A 273ILE A 167THR A 287 | None | 1.15A | 5eexU-1q8fA:undetectable5eexV-1q8fA:undetectable | 5eexU-1q8fA:13.505eexV-1q8fA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9c | PRECORRIN-8X METHYLMUTASE (Thermusthermophilus) |
PF02570(CbiC) | 5 | GLY A 188ALA A 196THR A 49THR A 183THR A 40 | None | 1.13A | 5eexU-1v9cA:undetectable5eexV-1v9cA:undetectable | 5eexU-1v9cA:19.255eexV-1v9cA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpx | PROTEIN(TRANSALDOLASE (EC2.2.1.2)) (Thermotogamaritima) |
PF00923(TAL_FSA) | 5 | GLY A 90ALA A 121THR A 104ILE A 91SER A 98 | None | 1.37A | 5eexU-1vpxA:undetectable5eexV-1vpxA:undetectable | 5eexU-1vpxA:18.535eexV-1vpxA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yy5 | FMS1 PROTEIN (Saccharomycescerevisiae) |
PF01593(Amino_oxidase) | 5 | GLY A 15ALA A 23THR A 252ILE A 13SER A 495 | FAD A 803 (-3.2A)NoneFAD A 803 (-4.6A)NoneNone | 1.01A | 5eexU-1yy5A:undetectable5eexV-1yy5A:undetectable | 5eexU-1yy5A:9.735eexV-1yy5A:9.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zb7 | NEUROTOXIN (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 5 | GLY A 238HIS A 237THR A 172ILE A 183THR A 271 | NoneNoneFLC A 501 (-4.7A)None ZN A 500 ( 4.4A) | 1.19A | 5eexU-1zb7A:undetectable5eexV-1zb7A:undetectable | 5eexU-1zb7A:9.285eexV-1zb7A:9.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zbr | CONSERVEDHYPOTHETICAL PROTEIN (Porphyromonasgingivalis) |
PF04371(PAD_porph) | 5 | GLY A 326HIS A 325ALA A 275THR A 211HIS A 208 | None | 1.32A | 5eexU-1zbrA:undetectable5eexV-1zbrA:undetectable | 5eexU-1zbrA:11.245eexV-1zbrA:11.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zwx | SPHINGOMYELINASE-C (Listeriaivanovii) |
PF03372(Exo_endo_phos) | 5 | GLY A 183THR A 186HIS A 185THR A 184ILE A 182 | None | 1.32A | 5eexU-1zwxA:undetectable5eexV-1zwxA:undetectable | 5eexU-1zwxA:13.625eexV-1zwxA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zwx | SPHINGOMYELINASE-C (Listeriaivanovii) |
PF03372(Exo_endo_phos) | 5 | GLY A 227THR A 186HIS A 185THR A 184ILE A 226 | None | 1.18A | 5eexU-1zwxA:undetectable5eexV-1zwxA:undetectable | 5eexU-1zwxA:13.625eexV-1zwxA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw4 | LYSINE-SPECIFICHISTONE DEMETHYLASE1 (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 5 | GLY A 285ALA A 293THR A 624ILE A 283SER A 817 | FAD A1001 (-3.2A)NoneFAD A1001 (-4.9A)NoneNone | 0.92A | 5eexU-2dw4A:undetectable5eexV-2dw4A:undetectable | 5eexU-2dw4A:8.155eexV-2dw4A:8.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fff | PENICILLIN-BINDINGPROTEIN 1B (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 5 | GLY B 677ALA B 688THR B 417HIS B 682ILE B 676 | NoneNoneNone NI B 901 (-2.8A)None | 1.05A | 5eexU-2fffB:undetectable5eexV-2fffB:undetectable | 5eexU-2fffB:11.035eexV-2fffB:11.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftp | HYDROXYMETHYLGLUTARYL-COA LYASE (Pseudomonasaeruginosa) |
PF00682(HMGL-like) | 5 | GLY A 206HIS A 207ALA A 215THR A 188ILE A 219 | None NA A3000 (-3.8A)NoneNoneNone | 1.25A | 5eexU-2ftpA:undetectable5eexV-2ftpA:undetectable | 5eexU-2ftpA:12.425eexV-2ftpA:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gez | L-ASPARAGINASE ALPHASUBUNITL-ASPARAGINASE BETASUBUNIT (Lupinus luteus;Lupinus luteus) |
PF01112(Asparaginase_2)PF01112(Asparaginase_2) | 5 | GLY B 195HIS A 9ALA A 67THR B 225THR B 209 | NoneNone NA A 401 (-4.6A)NoneNone | 1.40A | 5eexU-2gezB:undetectable5eexV-2gezB:undetectable | 5eexU-2gezB:20.155eexV-2gezB:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i3a | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Mycobacteriumtuberculosis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | GLY A 23HIS A 59ALA A 87HIS A 58ILE A 25 | None | 0.84A | 5eexU-2i3aA:undetectable5eexV-2i3aA:undetectable | 5eexU-2i3aA:12.785eexV-2i3aA:12.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5b | PHOSPHOMETHYLPYRIMIDINE KINASE (Bacillussubtilis) |
PF08543(Phos_pyr_kin) | 5 | GLY A 215ALA A 239THR A 26THR A 217ILE A 243 | ADP A 301 (-3.2A)NoneNoneNoneADP A 301 (-4.1A) | 1.31A | 5eexU-2i5bA:undetectable5eexV-2i5bA:undetectable | 5eexU-2i5bA:18.035eexV-2i5bA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o56 | PUTATIVE MANDELATERACEMASE (Salmonellaenterica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 90ALA A 96THR A 297ILE A 92SER A 98 | None | 1.35A | 5eexU-2o56A:undetectable5eexV-2o56A:undetectable | 5eexU-2o56A:11.995eexV-2o56A:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ok8 | PUTATIVEFERREDOXIN--NADPREDUCTASE (Plasmodiumfalciparum) |
PF00175(NAD_binding_1) | 5 | GLY A 55HIS A 157THR A 11THR A 154ILE A 57 | None | 1.34A | 5eexU-2ok8A:undetectable5eexV-2ok8A:undetectable | 5eexU-2ok8A:12.055eexV-2ok8A:12.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pqd | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Agrobacteriumsp.) |
PF00275(EPSP_synthase) | 5 | HIS A 32THR A 203HIS A 202THR A 101SER A 178 | NoneNoneNoneGG9 A 501 (-3.3A)GG9 A 501 ( 4.8A) | 1.33A | 5eexU-2pqdA:undetectable5eexV-2pqdA:undetectable | 5eexU-2pqdA:10.205eexV-2pqdA:10.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2prx | THIOESTERASESUPERFAMILY PROTEIN (Shewanellaloihica) |
PF03061(4HBT) | 5 | GLY A 117HIS A 68ALA A 76THR A 39ILE A 119 | None | 1.33A | 5eexU-2prxA:undetectable5eexV-2prxA:undetectable | 5eexU-2prxA:18.545eexV-2prxA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1y | CELL DIVISIONPROTEIN FTSZ (Mycobacteriumtuberculosis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | GLY A 107ALA A 79THR A 42THR A 106ILE A 16 | GSP A 401 (-3.6A)NoneGSP A 401 (-4.5A)GSP A 401 (-3.6A)None | 1.35A | 5eexU-2q1yA:undetectable5eexV-2q1yA:undetectable | 5eexU-2q1yA:12.945eexV-2q1yA:12.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfv | ISOCITRATEDEHYDROGENASE [NADP] (Saccharomycescerevisiae) |
PF00180(Iso_dh) | 5 | GLY A 276THR A 107HIS A 134ILE A 131SER A 198 | None | 1.39A | 5eexU-2qfvA:0.05eexV-2qfvA:0.0 | 5eexU-2qfvA:11.535eexV-2qfvA:11.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rbc | SUGAR KINASE (Agrobacteriumfabrum) |
PF00294(PfkB) | 5 | GLY A 258HIS A 257ALA A 281THR A 259SER A 278 | NoneNoneEDO A 331 ( 3.7A)NoneEDO A 331 (-3.3A) | 1.38A | 5eexU-2rbcA:undetectable5eexV-2rbcA:undetectable | 5eexU-2rbcA:11.545eexV-2rbcA:11.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v6o | THIOREDOXINGLUTATHIONEREDUCTASE (Schistosomamansoni) |
PF00462(Glutaredoxin)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 569HIS A 571THR A 580THR A 579ILE A 568 | PG4 A1595 (-4.3A)PG4 A1595 ( 3.7A)PG4 A1595 (-4.1A)PG4 A1595 (-3.9A)PG4 A1595 (-4.4A) | 1.23A | 5eexU-2v6oA:undetectable5eexV-2v6oA:undetectable | 5eexU-2v6oA:8.025eexV-2v6oA:8.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x7v | PROBABLEENDONUCLEASE 4 (Thermotogamaritima) |
PF01261(AP_endonuc_2) | 5 | GLY A 5HIS A 268HIS A 215ILE A 4THR A 261 | NoneNone ZN A1288 (-3.3A)NoneNone | 1.37A | 5eexU-2x7vA:undetectable5eexV-2x7vA:undetectable | 5eexU-2x7vA:13.505eexV-2x7vA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xzl | ATP-DEPENDENTHELICASE NAM7 (Saccharomycescerevisiae) |
PF09416(UPF1_Zn_bind)PF13086(AAA_11)PF13087(AAA_12) | 5 | GLY A 435ALA A 407THR A 442THR A 439SER A 402 | ADP A1854 (-3.1A)ADP A1854 ( 4.5A)NoneNoneNone | 1.25A | 5eexU-2xzlA:undetectable5eexV-2xzlA:undetectable | 5eexU-2xzlA:7.245eexV-2xzlA:7.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zy2 | L-ASPARTATE4-CARBOXYLYASE (Pseudomonas sp.ATCC 19121) |
PF00155(Aminotran_1_2) | 5 | GLY A 128HIS A 123ALA A 58ILE A 129SER A 62 | None | 1.27A | 5eexU-2zy2A:undetectable5eexV-2zy2A:undetectable | 5eexU-2zy2A:8.615eexV-2zy2A:8.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1n | NDP-SUGAR EPIMERASE (Thermoplasmavolcanium) |
PF01370(Epimerase) | 5 | GLY A 166THR A 178THR A 179THR A 112SER A 74 | NAD A3001 ( 4.6A)NoneNAD A3001 ( 4.7A)NAD A3001 ( 4.5A)None | 1.32A | 5eexU-3a1nA:undetectable5eexV-3a1nA:undetectable | 5eexU-3a1nA:13.025eexV-3a1nA:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9g | IAG-NUCLEOSIDEHYDROLASE (Trypanosomavivax) |
PF01156(IU_nuc_hydro) | 5 | GLY A 166ALA A 194THR A 284ILE A 187THR A 295 | None | 1.06A | 5eexU-3b9gA:undetectable5eexV-3b9gA:undetectable | 5eexU-3b9gA:13.115eexV-3b9gA:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7d | COBH, PRECORRIN-8XMETHYLMUTASE (Brucellaabortus) |
PF02570(CbiC) | 5 | GLY A 111ALA A 117THR A 138ILE A 110SER A 115 | None | 1.29A | 5eexU-3e7dA:undetectable5eexV-3e7dA:undetectable | 5eexU-3e7dA:17.315eexV-3e7dA:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ee4 | PROBABLERIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Mycobacteriumtuberculosis) |
PF00268(Ribonuc_red_sm) | 5 | GLY A 270ALA A 238THR A 267ILE A 235THR A 173 | NoneNoneNoneNoneMYR A 315 ( 4.9A) | 1.39A | 5eexU-3ee4A:undetectable5eexV-3ee4A:undetectable | 5eexU-3ee4A:12.955eexV-3ee4A:12.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eeg | 2-ISOPROPYLMALATESYNTHASE (Cytophagahutchinsonii) |
PF00682(HMGL-like) | 5 | GLY A 208ALA A 212THR A 239HIS A 204SER A 214 | None | 1.34A | 5eexU-3eegA:undetectable5eexV-3eegA:undetectable | 5eexU-3eegA:17.235eexV-3eegA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2b | DNA-DIRECTED DNAPOLYMERASE III ALPHACHAIN (Geobacilluskaustophilus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | ALA A 389THR A 349HIS A 348ILE A 364SER A 385 | NoneNone MG A 7 (-3.6A)NoneNone | 1.42A | 5eexU-3f2bA:undetectable5eexV-3f2bA:undetectable | 5eexU-3f2bA:6.365eexV-3f2bA:6.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpa | AMIDOHYDROLASE (unidentified) |
PF01979(Amidohydro_1) | 5 | GLY A 174ALA A 140THR A 457ILE A 173THR A 442 | None | 1.21A | 5eexU-3hpaA:undetectable5eexV-3hpaA:undetectable | 5eexU-3hpaA:10.655eexV-3hpaA:10.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvm | AGMATINE DEIMINASE (Helicobacterpylori) |
PF04371(PAD_porph) | 5 | GLY A 320HIS A 319ALA A 270THR A 205HIS A 202 | None | 1.33A | 5eexU-3hvmA:undetectable5eexV-3hvmA:undetectable | 5eexU-3hvmA:13.985eexV-3hvmA:13.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i04 | CARBON MONOXIDEDEHYDROGENASE/ACETYL-COA SYNTHASESUBUNIT BETA (Moorellathermoacetica) |
PF03063(Prismane) | 5 | GLY A 244HIS A 246ALA A 183ILE A 208THR A 189 | None | 1.42A | 5eexU-3i04A:undetectable5eexV-3i04A:undetectable | 5eexU-3i04A:7.875eexV-3i04A:7.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jsk | CYPBP37 PROTEIN (Neurosporacrassa) |
PF01946(Thi4) | 5 | GLY A 86ALA A 94THR A 246ILE A 84SER A 322 | AHZ A 500 (-3.0A)NoneNoneNoneNone | 1.14A | 5eexU-3jskA:undetectable5eexV-3jskA:undetectable | 5eexU-3jskA:13.375eexV-3jskA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k55 | BETA-HEMOLYSIN (Staphylococcusaureus) |
PF03372(Exo_endo_phos) | 5 | GLY A 192THR A 151HIS A 150THR A 149ILE A 191 | None | 1.15A | 5eexU-3k55A:undetectable5eexV-3k55A:undetectable | 5eexU-3k55A:13.735eexV-3k55A:13.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kto | RESPONSE REGULATORRECEIVER PROTEIN (Pseudoalteromonasatlantica) |
PF00072(Response_reg) | 5 | GLY A 58ALA A 109HIS A 85ILE A 128SER A 107 | None | 1.18A | 5eexU-3ktoA:undetectable5eexV-3ktoA:undetectable | 5eexU-3ktoA:18.945eexV-3ktoA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4g | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Homo sapiens) |
PF01409(tRNA-synt_2d) | 5 | GLY A 458THR A 328HIS A 327ILE A 373SER A 332 | PHE A 509 (-3.6A)NoneNoneNoneNone | 1.42A | 5eexU-3l4gA:undetectable5eexV-3l4gA:undetectable | 5eexU-3l4gA:9.815eexV-3l4gA:9.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6c | SERINE RACEMASE (Rattusnorvegicus) |
PF00291(PALP) | 5 | GLY A 88HIS A 87ALA A 102THR A 81ILE A 104 | None | 1.21A | 5eexU-3l6cA:undetectable5eexV-3l6cA:undetectable | 5eexU-3l6cA:14.115eexV-3l6cA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6r | SERINE RACEMASE (Homo sapiens) |
PF00291(PALP) | 5 | GLY A 88HIS A 87ALA A 102THR A 81ILE A 104 | None | 1.21A | 5eexU-3l6rA:undetectable5eexV-3l6rA:undetectable | 5eexU-3l6rA:12.845eexV-3l6rA:12.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8k | DIHYDROLIPOYLDEHYDROGENASE (Sulfolobussolfataricus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 14HIS A 16ALA A 325THR A 304ILE A 135 | None | 1.27A | 5eexU-3l8kA:undetectable5eexV-3l8kA:undetectable | 5eexU-3l8kA:11.765eexV-3l8kA:11.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mcp | GLUCOKINASE (Parabacteroidesdistasonis) |
PF00480(ROK) | 5 | GLY A 28ALA A 352ILE A 25THR A 127SER A 350 | None | 1.38A | 5eexU-3mcpA:undetectable5eexV-3mcpA:undetectable | 5eexU-3mcpA:13.195eexV-3mcpA:13.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q8n | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 5 | GLY A 237HIS A 234ALA A 173THR A 416THR A 194 | None | 1.16A | 5eexU-3q8nA:undetectable5eexV-3q8nA:undetectable | 5eexU-3q8nA:9.985eexV-3q8nA:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwb | PYRIDOXAL4-DEHYDROGENASE (Mesorhizobiumloti) |
PF13561(adh_short_C2) | 5 | GLY A 160ALA A 140THR A 116THR A 165SER A 138 | None | 1.20A | 5eexU-3rwbA:undetectable5eexV-3rwbA:undetectable | 5eexU-3rwbA:16.065eexV-3rwbA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ryk | DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE (Bacillusanthracis) |
PF00908(dTDP_sugar_isom) | 5 | GLY A 60HIS A 62HIS A 119ILE A 58SER A 50 | NonePOP A 182 ( 4.5A)NoneNoneNone | 1.30A | 5eexU-3rykA:1.25eexV-3rykA:1.2 | 5eexU-3rykA:18.405eexV-3rykA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqo | CYSTEINYL-TRNASYNTHETASE (Coxiellaburnetii) |
PF01406(tRNA-synt_1e)PF09190(DALR_2) | 5 | HIS A 235ALA A 212HIS A 236ILE A 208SER A 214 | ZN A 461 (-3.4A)NoneNoneNoneNone | 1.22A | 5eexU-3tqoA:undetectable5eexV-3tqoA:undetectable | 5eexU-3tqoA:10.755eexV-3tqoA:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr1 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Coxiellaburnetii) |
PF00275(EPSP_synthase) | 5 | HIS A 25THR A 197HIS A 196THR A 96SER A 172 | NoneNonePO4 A 442 ( 4.9A)PO4 A 440 (-3.5A)PO4 A 441 (-2.8A) | 1.37A | 5eexU-3tr1A:undetectable5eexV-3tr1A:undetectable | 5eexU-3tr1A:10.125eexV-3tr1A:10.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txx | PUTRESCINECARBAMOYLTRANSFERASE (Enterococcusfaecalis) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | GLY A 124HIS A 130THR A 132ILE A 122SER A 58 | None | 1.16A | 5eexU-3txxA:undetectable5eexV-3txxA:undetectable | 5eexU-3txxA:11.215eexV-3txxA:11.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u0f | BETA-KETOACYLSYNTHASE (Brucellaabortus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 332HIS A 333ALA A 326THR A 331THR A 338 | None | 1.33A | 5eexU-3u0fA:undetectable5eexV-3u0fA:undetectable | 5eexU-3u0fA:10.225eexV-3u0fA:10.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wpe | TOLL-LIKE RECEPTOR 9 (Bos taurus) |
PF13516(LRR_6)PF13855(LRR_8) | 5 | GLY A 133HIS A 151THR A 152ILE A 134SER A 148 | None | 1.18A | 5eexU-3wpeA:undetectable5eexV-3wpeA:undetectable | 5eexU-3wpeA:7.175eexV-3wpeA:7.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zte | TRYPTOPHAN OPERONRNA-BINDINGATTENUATION PROTEIN(TRAP) (Bacilluslicheniformis) |
PF02081(TrpBP) | 7 | GLY A 23HIS A 33HIS A 34THR A 49HIS A 51THR A 52ILE A 55 | TRP A 80 (-3.5A)NoneTRP A 80 ( 4.9A)TRP A 80 (-2.8A)NoneTRP A 80 (-3.6A)TRP A 80 ( 4.6A) | 0.26A | 5eexU-3zteA:14.25eexV-3zteA:14.1 | 5eexU-3zteA:78.215eexV-3zteA:78.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zzl | TRANSCRIPTIONATTENUATION PROTEINMTRB (Bacillushalodurans) |
PF02081(TrpBP) | 7 | GLY A 23HIS A 33HIS A 34ALA A 46THR A 49HIS A 51THR A 52 | TRP A 81 (-3.5A)NoneTRP A 81 ( 4.7A)TRP A 81 ( 3.7A)TRP A 81 ( 2.9A)NoneTRP A 81 (-3.7A) | 0.34A | 5eexU-3zzlA:13.15eexV-3zzlA:13.1 | 5eexU-3zzlA:71.435eexV-3zzlA:71.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zzq | TRANSCRIPTIONATTENUATION PROTEINMTRB (Bacillussubtilis) |
PF02081(TrpBP) | 7 | GLY A 23HIS A 33HIS A 34ALA A 46THR A 49THR A 52ILE A 55 | TRP A 81 (-3.4A)TRP A 81 ( 4.9A)TRP A 81 ( 4.9A)TRP A 81 ( 3.7A)TRP A 81 ( 2.9A)TRP A 81 (-3.8A)TRP A 81 ( 4.4A) | 0.19A | 5eexU-3zzqA:13.65eexV-3zzqA:13.6 | 5eexU-3zzqA:80.005eexV-3zzqA:80.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zzs | TRANSCRIPTIONATTENUATION PROTEINMTRB (Geobacillusstearothermophilus) |
PF02081(TrpBP) | 8 | GLY A 23HIS A 33HIS A 34ALA A 46THR A 49HIS A 51THR A 52ILE A 55 | TRP A1072 (-3.5A)NoneTRP A1072 ( 4.7A)TRP A1072 ( 3.8A)TRP A1072 (-2.9A)NoneTRP A1072 (-3.8A)TRP A1072 ( 4.4A) | 0.18A | 5eexU-3zzsA:13.55eexV-3zzsA:13.5 | 5eexU-3zzsA:100.005eexV-3zzsA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0s | OCTENOYL-COAREDUCTASE/CARBOXYLASE (Streptomycescinnabarigriseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 228HIS A 313THR A 318THR A 314SER A 322 | NAP A1447 (-3.2A)NAP A1447 (-4.3A)NoneNAP A1447 (-4.6A)None | 1.29A | 5eexU-4a0sA:undetectable5eexV-4a0sA:undetectable | 5eexU-4a0sA:10.765eexV-4a0sA:10.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aj9 | CATALASE-3 (Neurosporacrassa) |
PF00199(Catalase)PF06628(Catalase-rel) | 5 | ALA A 320THR A 377HIS A 249THR A 250ILE A 315 | NoneNoneHEM A1715 (-3.9A)NoneNone | 1.25A | 5eexU-4aj9A:undetectable5eexV-4aj9A:undetectable | 5eexU-4aj9A:8.765eexV-4aj9A:8.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4b27 | TRANSCRIPTIONATTENUATION PROTEINMTRB (Bacillussubtilis) |
PF02081(TrpBP) | 8 | GLY A 23HIS A 33HIS A 34ALA A 46THR A 49HIS A 51THR A 52ILE A 55 | GLY A 23 (-0.0A)HIS A 33 ( 1.0A)HIS A 34 ( 1.0A)ALA A 46 ( 0.0A)THR A 49 (-0.8A)HIS A 51 ( 1.0A)THR A 52 (-0.8A)ILE A 55 ( 0.6A) | 0.27A | 5eexU-4b27A:13.15eexV-4b27A:13.1 | 5eexU-4b27A:76.325eexV-4b27A:76.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bx9 | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 33A (Homo sapiens) |
PF00995(Sec1) | 5 | ALA A 500THR A 572THR A 545ILE A 547SER A 504 | None | 1.10A | 5eexU-4bx9A:undetectable5eexV-4bx9A:undetectable | 5eexU-4bx9A:7.915eexV-4bx9A:7.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d9i | DIAMINOPROPIONATEAMMONIA-LYASE (Escherichiacoli) |
PF00291(PALP) | 5 | GLY A 124HIS A 123ALA A 138THR A 117ILE A 140 | None | 1.10A | 5eexU-4d9iA:undetectable5eexV-4d9iA:undetectable | 5eexU-4d9iA:11.425eexV-4d9iA:11.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e6e | CELL DIVISIONPROTEIN FTSZ (Thermobifidafusca) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | GLY A 107ALA A 79THR A 42THR A 106ILE A 16 | SO4 A 607 (-3.4A)NoneNoneSO4 A 607 (-4.3A)None | 1.26A | 5eexU-4e6eA:undetectable5eexV-4e6eA:undetectable | 5eexU-4e6eA:12.065eexV-4e6eA:12.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e6y | CITRATE SYNTHASE (Vibriovulnificus) |
PF00285(Citrate_synt) | 5 | HIS A 69ALA A 394THR A 236ILE A 390THR A 58 | None | 1.41A | 5eexU-4e6yA:undetectable5eexV-4e6yA:undetectable | 5eexU-4e6yA:11.675eexV-4e6yA:11.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fc7 | PEROXISOMAL2,4-DIENOYL-COAREDUCTASE (Homo sapiens) |
PF13561(adh_short_C2) | 5 | ALA A 69HIS A 54THR A 55ILE A 57THR A 76 | None | 1.21A | 5eexU-4fc7A:undetectable5eexV-4fc7A:undetectable | 5eexU-4fc7A:16.605eexV-4fc7A:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hsu | LYSINE-SPECIFICHISTONE DEMETHYLASE1B (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM)PF07496(zf-CW) | 5 | GLY A 389ALA A 397THR A 626ILE A 387SER A 811 | FAD A 901 (-3.3A)NoneNoneNoneNone | 0.96A | 5eexU-4hsuA:undetectable5eexV-4hsuA:undetectable | 5eexU-4hsuA:7.645eexV-4hsuA:7.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6m | ACTIN-LIKE PROTEINARP9 (Saccharomycescerevisiae) |
PF00022(Actin) | 5 | GLY B 191THR B 340THR B 339ILE B 194THR B 169 | None | 1.04A | 5eexU-4i6mB:undetectable5eexV-4i6mB:undetectable | 5eexU-4i6mB:11.935eexV-4i6mB:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jre | IMMUNOGLOBULINGAMMA-2A, HEAVYCHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | GLY B 33ALA B 79THR B 53ILE B 51SER B 77 | None | 1.04A | 5eexU-4jreB:undetectable5eexV-4jreB:undetectable | 5eexU-4jreB:15.895eexV-4jreB:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpo | NUCLEOSIDEN-RIBOHYDROLASE 3 (Zea mays) |
PF01156(IU_nuc_hydro) | 5 | HIS A 66ALA A 103THR A 44THR A 40ILE A 34 | None | 1.28A | 5eexU-4kpoA:undetectable5eexV-4kpoA:undetectable | 5eexU-4kpoA:15.075eexV-4kpoA:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpr | THIOREDOXINREDUCTASE 1,CYTOPLASMIC (Rattusnorvegicus) |
no annotation | 5 | GLY E 470HIS E 472THR E 481THR E 480ILE E 469 | None | 1.16A | 5eexU-4kprE:undetectable5eexV-4kprE:undetectable | 5eexU-4kprE:9.645eexV-4kprE:9.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oht | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE (Streptococcuspyogenes) |
PF00171(Aldedh) | 5 | GLY A 390ALA A 381THR A 409ILE A 407SER A 384 | None | 1.27A | 5eexU-4ohtA:undetectable5eexV-4ohtA:undetectable | 5eexU-4ohtA:9.895eexV-4ohtA:9.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov4 | 2-ISOPROPYLMALATESYNTHASE (Leptospirabiflexa) |
PF00682(HMGL-like) | 5 | GLY A 213ALA A 217THR A 244HIS A 209SER A 219 | NoneNoneNone ZN A 401 ( 3.4A)None | 1.16A | 5eexU-4ov4A:undetectable5eexV-4ov4A:undetectable | 5eexU-4ov4A:11.115eexV-4ov4A:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0g | PROBABLEACETYL-/PROPIONYL-COA CARBOXYLASE (BETASUBUNIT) ACCD1 (Mycobacteriumtuberculosis) |
PF01039(Carboxyl_trans) | 5 | GLY A 84ALA A 71HIS A 119THR A 115THR A 87 | None | 1.37A | 5eexU-4q0gA:undetectable5eexV-4q0gA:undetectable | 5eexU-4q0gA:9.335eexV-4q0gA:9.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgn | 3-HYDROXYACYL-COADEHYDROGENASE (Burkholderiathailandensis) |
PF00106(adh_short) | 5 | GLY A 164ALA A 144THR A 115THR A 169SER A 142 | None | 1.14A | 5eexU-4xgnA:undetectable5eexV-4xgnA:undetectable | 5eexU-4xgnA:13.855eexV-4xgnA:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ah1 | TRIACYLGLYCEROLLIPASE (Clostridiumbotulinum) |
no annotation | 5 | GLY A 184HIS A 84ALA A 304THR A 187SER A 126 | None | 1.35A | 5eexU-5ah1A:undetectable5eexV-5ah1A:undetectable | 5eexU-5ah1A:10.955eexV-5ah1A:10.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmy | BETA-GALACTOSIDASE (Bifidobacteriumbifidum) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | GLY A 758ALA A 741HIS A 647THR A 756THR A 674 | None | 1.40A | 5eexU-5dmyA:1.65eexV-5dmyA:1.6 | 5eexU-5dmyA:6.415eexV-5dmyA:6.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dx5 | METHIONINEGAMMA-LYASE (Clostridiumsporogenes) |
PF01053(Cys_Met_Meta_PP) | 5 | GLY A 245ALA A 85THR A 244ILE A 240SER A 87 | NoneNoneNoneNonePLP A 501 (-3.7A) | 1.32A | 5eexU-5dx5A:undetectable5eexV-5dx5A:undetectable | 5eexU-5dx5A:11.505eexV-5dx5A:11.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eex | TRANSCRIPTIONATTENUATION PROTEINMTRB (Geobacillusstearothermophilus) |
PF02081(TrpBP) | 8 | GLY A 23HIS A 33HIS A 34ALA A 46THR A 49HIS A 51THR A 52ILE A 55 | None | 0.21A | 5eexU-5eexA:15.85eexV-5eexA:15.8 | 5eexU-5eexA:100.005eexV-5eexA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eul | PROTEIN TRANSLOCASESUBUNIT SECY (Geobacillusthermodenitrificans) |
PF00344(SecY) | 5 | GLY Y 178ALA Y 185THR Y 21ILE Y 182THR Y 412 | None | 1.30A | 5eexU-5eulY:undetectable5eexV-5eulY:undetectable | 5eexU-5eulY:10.615eexV-5eulY:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f9p | ANTHRONEOXIDASE-LIKE PROTEIN (Streptomycesambofaciens) |
PF03992(ABM) | 5 | GLY A 117HIS A 226THR A 48ILE A 116SER A 229 | None | 1.38A | 5eexU-5f9pA:undetectable5eexV-5f9pA:undetectable | 5eexU-5f9pA:15.355eexV-5f9pA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hab | RIBONUCLEASE J (Methanolobuspsychrophilus) |
PF07521(RMMBL)PF12706(Lactamase_B_2) | 5 | GLY A 83HIS A 87THR A 105THR A 108ILE A 112 | None | 1.26A | 5eexU-5habA:undetectable5eexV-5habA:undetectable | 5eexU-5habA:12.915eexV-5habA:12.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzk | INTERSECTIN-1,NPH1-1,INTERSECTIN-1 (Avena sativa;Homo sapiens) |
PF00621(RhoGEF)PF13426(PAS_9)PF16652(PH_13) | 5 | GLY B1459HIS B1548THR B1539HIS B1546ILE B1458 | None | 1.18A | 5eexU-5hzkB:undetectable5eexV-5hzkB:undetectable | 5eexU-5hzkB:9.115eexV-5hzkB:9.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3d | LYSINE-SPECIFICHISTONE DEMETHYLASE1A (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 5 | GLY A 285ALA A 293THR A 624ILE A 283SER A 817 | FAD A 901 (-3.3A)NoneNoneNoneNone | 0.94A | 5eexU-5l3dA:undetectable5eexV-5l3dA:undetectable | 5eexU-5l3dA:6.275eexV-5l3dA:6.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lgc | ARCE4A (Arthrobactersp. AW19M34-1) |
PF01522(Polysacc_deac_1) | 5 | GLY A 80THR A 199HIS A 77THR A 54ILE A 118 | None | 1.11A | 5eexU-5lgcA:undetectable5eexV-5lgcA:undetectable | 5eexU-5lgcA:17.895eexV-5lgcA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnn | CTATC (Chaetomiumthermophilum) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | GLY A2074HIS A2081THR A2083ILE A2072SER A2008 | None | 1.15A | 5eexU-5nnnA:undetectable5eexV-5nnnA:undetectable | 5eexU-5nnnA:15.085eexV-5nnnA:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o1m | RUBBER OXYGENASE (Streptomycessp. K30) |
PF09995(DUF2236) | 5 | GLY A 172ALA A 180THR A 190ILE A 175SER A 186 | None | 1.20A | 5eexU-5o1mA:undetectable5eexV-5o1mA:undetectable | 5eexU-5o1mA:12.645eexV-5o1mA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2p | SUGAR ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN (Treponemapallidum) |
PF01547(SBP_bac_1) | 5 | GLY A 310ALA A 149THR A 309ILE A 147THR A 199 | EDO A 504 ( 3.9A)NoneNoneNoneEDO A 504 ( 4.2A) | 1.34A | 5eexU-5u2pA:undetectable5eexV-5u2pA:undetectable | 5eexU-5u2pA:11.245eexV-5u2pA:11.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux5 | BIFUNCTIONAL PROTEINPROLINE UTILIZATIONA (PUTA) (Corynebacteriumfreiburgense) |
PF00171(Aldedh)PF01619(Pro_dh) | 5 | GLY A 538HIS A 542ALA A 481HIS A 755THR A 541 | None | 1.24A | 5eexU-5ux5A:undetectable5eexV-5ux5A:undetectable | 5eexU-5ux5A:5.765eexV-5ux5A:5.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux5 | BIFUNCTIONAL PROTEINPROLINE UTILIZATIONA (PUTA) (Corynebacteriumfreiburgense) |
PF00171(Aldedh)PF01619(Pro_dh) | 5 | GLY A 874ALA A 726THR A 846ILE A 696SER A 724 | NoneNoneNoneNoneSO4 A2003 (-2.4A) | 1.17A | 5eexU-5ux5A:undetectable5eexV-5ux5A:undetectable | 5eexU-5ux5A:5.765eexV-5ux5A:5.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1j | THIOREDOXINGLUTATHIONEREDUCTASE (Echinococcusgranulosus) |
no annotation | 5 | GLY A 568HIS A 570THR A 579THR A 578ILE A 567 | None | 1.19A | 5eexU-5w1jA:undetectable5eexV-5w1jA:undetectable | 5eexU-5w1jA:8.725eexV-5w1jA:8.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6q | ALDEHYDE OXIDASELARGE SUBUNIT (Methylobacillussp. KY4400) |
no annotation | 5 | GLY C 65ALA C 278HIS C 271ILE C 138SER C 276 | None | 1.38A | 5eexU-5y6qC:undetectable5eexV-5y6qC:undetectable | 5eexU-5y6qC:undetectable5eexV-5y6qC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6r | GENOME POLYPROTEIN (Pestivirus C) |
no annotation | 5 | GLY A 147ALA A 622HIS A 626THR A 627ILE A 148 | SO4 A 706 ( 4.4A)NoneSO4 A 706 (-3.9A)NoneNone | 1.18A | 5eexU-5y6rA:undetectable5eexV-5y6rA:undetectable | 5eexU-5y6rA:undetectable5eexV-5y6rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6r | GENOME POLYPROTEIN (Pestivirus C) |
no annotation | 5 | GLY A 147ALA A 622THR A 627ILE A 148SER A 618 | SO4 A 706 ( 4.4A)NoneNoneNoneNone | 1.34A | 5eexU-5y6rA:undetectable5eexV-5y6rA:undetectable | 5eexU-5y6rA:undetectable5eexV-5y6rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ygr | DIAMINOPROPIONATEAMMONIA LYASE (Salmonellaenterica) |
no annotation | 5 | GLY A 126ALA A 133THR A 122THR A 124ILE A 159 | PO4 A 504 (-4.5A)NoneNonePO4 A 504 (-3.6A)None | 1.07A | 5eexU-5ygrA:undetectable5eexV-5ygrA:undetectable | 5eexU-5ygrA:undetectable5eexV-5ygrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z73 | ALR0819 PROTEIN (Nostoc sp. PCC7120) |
no annotation | 5 | GLY A 34ALA A 60THR A 35ILE A 71SER A 58 | None | 1.26A | 5eexU-5z73A:undetectable5eexV-5z73A:undetectable | 5eexU-5z73A:undetectable5eexV-5z73A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zln | TOLL-LIKE RECEPTOR 9 (Mus musculus) |
no annotation | 5 | GLY A 134HIS A 152THR A 153ILE A 135SER A 149 | None | 1.13A | 5eexU-5zlnA:undetectable5eexV-5zlnA:undetectable | 5eexU-5zlnA:undetectable5eexV-5zlnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gef | TYPE IV SECRETIONSYSTEM PROTEIN DOTB (Yersiniapseudotuberculosis) |
no annotation | 5 | GLY A 164HIS A 268ALA A 260ILE A 165THR A 266 | GLY A 164 ( 0.0A)HIS A 268 ( 1.0A)ALA A 260 ( 0.0A)ILE A 165 ( 0.7A)THR A 266 ( 0.8A) | 1.32A | 5eexU-6gefA:undetectable5eexV-6gefA:undetectable | 5eexU-6gefA:undetectable5eexV-6gefA:undetectable |