SIMILAR PATTERNS OF AMINO ACIDS FOR 5ECO_D_LEUD602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		4 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.72A 5ecoD-1di6A:
0.0		 5ecoD-1di6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fj1 HYBRIDOMA ANTIBODY
LA2 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 109
GLU B  89
 None
 0.73A 5ecoD-1fj1B:
0.0		 5ecoD-1fj1B:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.84A 5ecoD-1h3pH:
0.0		 5ecoD-1h3pH:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 ALA B 392
THR B 391
VAL B 416
GLU B 389
 None
 0.82A 5ecoD-1i8kB:
0.0		 5ecoD-1i8kB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  91
THR H  90
VAL H 114
GLU H  88
 None
 0.84A 5ecoD-1i9iH:
0.0		 5ecoD-1i9iH:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikf IGG1-KAPPA R45-45-11
FAB (HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 122
GLU H  89
 None
 0.83A 5ecoD-1ikfH:
0.0		 5ecoD-1ikfH:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgu ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.83A 5ecoD-1jguH:
undetectable		 5ecoD-1jguH:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo4 IG GAMMA 2A HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  91
THR H  90
VAL H 114
GLU H  88
 None
 0.79A 5ecoD-1lo4H:
0.0		 5ecoD-1lo4H:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvf IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 122
GLU A  89
 None
 0.82A 5ecoD-1mvfA:
0.0		 5ecoD-1mvfA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op9 HL6 CAMEL VHH
FRAGMENT

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA A  89
THR A  88
VAL A 117
GLU A  86
 None
 0.82A 5ecoD-1op9A:
undetectable		 5ecoD-1op9A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1seq MONOCLONAL ANTIBODY
MNAC13

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.82A 5ecoD-1seqH:
undetectable		 5ecoD-1seqH:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t04 HUZAF ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 113
GLU B  89
 None
 0.83A 5ecoD-1t04B:
undetectable		 5ecoD-1t04B:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj3 IGG FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B 392
THR B 391
VAL B 413
GLU B 389
 None
 0.81A 5ecoD-1uj3B:
undetectable		 5ecoD-1uj3B:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.62A 5ecoD-2ejvA:
undetectable		 5ecoD-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0w LMO2234 PROTEIN

(Listeria
monocytogenes) 		PF01261
(AP_endonuc_2) 		4 ALA A 269
THR A 270
VAL A 273
VAL A 249
 None
 0.84A 5ecoD-2g0wA:
undetectable		 5ecoD-2g0wA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otu FV HEAVY CHAIN
VARIABLE DOMAIN

(Mus musculus) 		PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 114
GLU B  89
 None
 0.84A 5ecoD-2otuB:
undetectable		 5ecoD-2otuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4a ANTIBODY CAB-RN05

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 117
GLU B  89
 None
 0.81A 5ecoD-2p4aB:
undetectable		 5ecoD-2p4aB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5y ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Homo sapiens) 		PF00644
(PARP) 		5 ALA A 788
THR A 789
VAL A 838
TYR A 833
GLU A 808
 None
 1.50A 5ecoD-2x5yA:
undetectable		 5ecoD-2x5yA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7l FAB HEAVY CHAIN

(unidentified) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  90
THR A  89
VAL A 113
GLU A  87
 None
 0.82A 5ecoD-2x7lA:
undetectable		 5ecoD-2x7lA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05

(Homo sapiens) 		PF07686
(V-set) 		4 ALA D  92
THR D  91
VAL D 127
GLU D  89
 None
 0.81A 5ecoD-2xtjD:
undetectable		 5ecoD-2xtjD:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybr SINGLE CHAIN
ANTIBODY FRAGMENT
9004G

(Homo sapiens) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 113
GLU A  89
 None
 0.84A 5ecoD-2ybrA:
undetectable		 5ecoD-2ybrA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.76A 5ecoD-2z8eA:
undetectable		 5ecoD-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.82A 5ecoD-2zj8A:
1.7		 5ecoD-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		no annotation 4 ALA C 230
VAL C 229
TYR C 182
VAL C   7
 None
 0.84A 5ecoD-3a28C:
undetectable		 5ecoD-3a28C:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn9 E2 FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA D  88
THR D  87
VAL D 109
GLU D  85
 None
 0.82A 5ecoD-3bn9D:
undetectable		 5ecoD-3bn9D:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eak NBBCII10-FGLA

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA A  95
THR A  94
VAL A 124
GLU A  92
 None
 0.84A 5ecoD-3eakA:
undetectable		 5ecoD-3eakA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzu IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA H  94
THR H  93
VAL H 114
GLU H  91
 None
 0.79A 5ecoD-3fzuH:
undetectable		 5ecoD-3fzuH:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 ALA A 402
THR A 403
VAL A 406
GLU A 372
 None
 0.82A 5ecoD-3ikmA:
2.6		 5ecoD-3ikmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7u ANTIBODY

(Lama glama) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 118
GLU A  89
 None
 0.81A 5ecoD-3k7uA:
undetectable		 5ecoD-3k7uA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx0 UNCHARACTERIZED
PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF08448
(PAS_4) 		5 ALA X  59
VAL X  62
TYR X  63
VAL X  29
HIS X  36
 None
 1.16A 5ecoD-3kx0X:
undetectable		 5ecoD-3kx0X:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3liz 4C3 MONOCLONAL
ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 115
GLU H  89
 None
 0.83A 5ecoD-3lizH:
undetectable		 5ecoD-3lizH:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
EPSILON

(Bos taurus) 		PF04733
(Coatomer_E) 		4 ALA A 185
THR A 186
VAL A 189
GLU A 177
 None
 0.82A 5ecoD-3mkrA:
undetectable		 5ecoD-3mkrA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r08 MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 HEAVY CHAIN

(Cricetulus
migratorius) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.81A 5ecoD-3r08H:
undetectable		 5ecoD-3r08H:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0m LLAMA VHH A12

(Lama glama) 		PF07686
(V-set) 		4 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.82A 5ecoD-3r0mA:
undetectable		 5ecoD-3r0mA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb SINGLE DOMAIN
ANTIBODY VHH

(Lama glama) 		PF07686
(V-set) 		4 ALA A  93
THR A  92
VAL A 124
GLU A  90
 None
 0.79A 5ecoD-3stbA:
undetectable		 5ecoD-3stbA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00106
(adh_short) 		4 ALA A 231
VAL A 230
TYR A 183
VAL A  10
 None
 0.83A 5ecoD-3wtcA:
undetectable		 5ecoD-3wtcA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3f HEAVY CHAIN OF KMTR2

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 122
GLU H  89
 None
 0.83A 5ecoD-3x3fH:
undetectable		 5ecoD-3x3fH:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 ALA A 507
THR A 508
VAL A 511
GLU A 501
 None
 0.75A 5ecoD-4f7zA:
0.9		 5ecoD-4f7zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgo PERIPLASMIC PROTEIN

(Legionella
pneumophila) 		PF06035
(Peptidase_C93) 		5 ALA A 163
VAL A 207
TYR A 208
GLU A 138
HIS A 172
 None
None
None
CA  A 301 (-4.2A)
None
 1.11A 5ecoD-4fgoA:
undetectable		 5ecoD-4fgoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.74A 5ecoD-4g1pA:
0.1		 5ecoD-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ALA C 750
THR C 751
VAL C 756
VAL C 803
 None
 0.73A 5ecoD-4hb4C:
1.8		 5ecoD-4hb4C:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hf5 FAB 8F8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.83A 5ecoD-4hf5H:
undetectable		 5ecoD-4hf5H:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hii FAB 023.102 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  88
THR B  87
VAL B 109
GLU B  85
 None
 0.78A 5ecoD-4hiiB:
undetectable		 5ecoD-4hiiB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 ALA A 773
THR A 774
VAL A 777
TYR A 778
 None
 0.77A 5ecoD-4jzaA:
1.3		 5ecoD-4jzaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 ALA A 493
THR A 494
VAL A 499
TYR A 500
 None
 0.68A 5ecoD-4kf7A:
undetectable		 5ecoD-4kf7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvn HUMAN IGG HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 121
GLU H  89
 None
 0.83A 5ecoD-4kvnH:
undetectable		 5ecoD-4kvnH:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lly MUTATED PERTUZUMAB
FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 115
GLU A  89
 None
 0.82A 5ecoD-4llyA:
undetectable		 5ecoD-4llyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxv ANTI-LYMPHOTOXIN
ALPHA ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA F  88
THR F  87
VAL F 109
GLU F  85
 None
 0.84A 5ecoD-4mxvF:
undetectable		 5ecoD-4mxvF:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc2 B39 VHH

(Lama glama) 		PF07686
(V-set) 		4 ALA B  91
THR B  90
VAL B 118
GLU B  88
 None
 0.84A 5ecoD-4nc2B:
undetectable		 5ecoD-4nc2B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis) 		PF00994
(MoCF_biosynth) 		4 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.77A 5ecoD-4nwoA:
undetectable		 5ecoD-4nwoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5l FAB F045-092 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.79A 5ecoD-4o5lH:
undetectable		 5ecoD-4o5lH:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onf 3D6 FAB ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 115
GLU H  89
 None
 0.83A 5ecoD-4onfH:
undetectable		 5ecoD-4onfH:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p49 ANTIBODY SCFV B8

(Gallus gallus) 		PF07686
(V-set) 		4 ALA A 213
THR A 212
VAL A 240
GLU A 210
 None
 0.80A 5ecoD-4p49A:
undetectable		 5ecoD-4p49A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6i HEAVY CHAIN OF
MURINE 2D5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  88
THR B  87
VAL B 109
GLU B  85
 None
 0.81A 5ecoD-4q6iB:
undetectable		 5ecoD-4q6iB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlr LLAMA NANOBODY N02
VH DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 120
GLU A  89
 None
 0.83A 5ecoD-4qlrA:
1.3		 5ecoD-4qlrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rau RTOFAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  94
THR B  93
VAL B 117
GLU B  91
 None
 0.78A 5ecoD-4rauB:
undetectable		 5ecoD-4rauB:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wen ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION

(Lama glama) 		PF07686
(V-set) 		4 ALA B 891
THR B 890
VAL B 917
GLU B 888
 None
 0.81A 5ecoD-4wenB:
1.3		 5ecoD-4wenB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xml HEAVY CHAIN OF HIV-1
GP120 V3-SPECIFIC
HUMAN MONOCLONAL
ANTIBODY 2424

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.84A 5ecoD-4xmlH:
undetectable		 5ecoD-4xmlH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7m HI113 PROTEIN

(Lama glama) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 125
GLU A  89
 None
 0.83A 5ecoD-4y7mA:
undetectable		 5ecoD-4y7mA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y8d NANOBODY

(Lama glama) 		PF07686
(V-set) 		4 ALA C  89
THR C  88
VAL C 117
GLU C  86
 None
 0.80A 5ecoD-4y8dC:
undetectable		 5ecoD-4y8dC:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 ALA A 186
THR A 187
VAL A 190
TYR A 180
HIS A 183
 None
 1.43A 5ecoD-4y9lA:
undetectable		 5ecoD-4y9lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.83A 5ecoD-4ydkH:
undetectable		 5ecoD-4ydkH:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhp FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 117
GLU A  89
 None
 0.83A 5ecoD-4yhpA:
undetectable		 5ecoD-4yhpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqx JES6-1 VH DOMAIN

(Rattus
norvegicus) 		PF07686
(V-set) 		4 ALA H  95
THR H  94
VAL H 120
GLU H  92
 None
 0.83A 5ecoD-4yqxH:
undetectable		 5ecoD-4yqxH:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq7 FAB 5F-10-HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 114
GLU A  89
 None
 0.77A 5ecoD-5bq7A:
undetectable		 5ecoD-5bq7A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhx ANTI-REV ANTIBODY
FAB SINGLE-CHAIN
VARIABLE FRAGMENT,
LIGHT CHAIN,ANTI-REV
ANTIBODY FAB
SINGLE-CHAIN
VARIABLE FRAGMENT,
HEAVY CHAIN

(Oryctolagus
cuniculus) 		PF07686
(V-set) 		4 ALA B 200
THR B 199
VAL B 223
GLU B 197
 None
 0.84A 5ecoD-5dhxB:
undetectable		 5ecoD-5dhxB:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dr5 ABD09097 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 111
GLU H  89
 None
 0.82A 5ecoD-5dr5H:
undetectable		 5ecoD-5dr5H:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds8 FAB HPU98 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
EDO  A 303 (-4.6A)
None
None
 0.84A 5ecoD-5ds8A:
undetectable		 5ecoD-5ds8A:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		7 ALA A 165
THR A 166
VAL A 169
TYR A 170
VAL A 222
GLU A 533
HIS A 534
 LEU  A 602 (-3.1A)
LEU  A 602 ( 3.0A)
LEU  A 602 (-4.6A)
LEU  A 602 (-4.4A)
JAA  A 601 (-4.1A)
MG  A 603 (-3.9A)
LEU  A 602 (-4.9A)
 0.70A 5ecoD-5ecoA:
61.9		 5ecoD-5ecoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA E  92
THR E  91
VAL E 123
GLU E  89
 None
 0.81A 5ecoD-5fgcE:
undetectable		 5ecoD-5fgcE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grv HOMO-SPECIFIC
DIABODY HEAVY CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ALA L  91
THR L  90
VAL L 114
GLU L  88
 None
 0.81A 5ecoD-5grvL:
undetectable		 5ecoD-5grvL:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs3 DIABODY PROTEIN

(Homo sapiens) 		no annotation 4 ALA H  92
THR H  91
VAL H 115
GLU H  89
 None
 0.84A 5ecoD-5gs3H:
undetectable		 5ecoD-5gs3H:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		4 ALA A 345
THR A 346
VAL A 349
VAL A 306
 None
 0.72A 5ecoD-5h7dA:
undetectable		 5ecoD-5h7dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifh HEAVY CHAIN OF THE
FAB FRAGMENT FROM
BCR DERIVED FROM THE
P11475 CLL CLONE

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 112
GLU H  89
 None
 0.78A 5ecoD-5ifhH:
undetectable		 5ecoD-5ifhH:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqh NANOBODY60, NB60

(Lama glama) 		no annotation 4 ALA D  91
THR D  90
VAL D 115
GLU D  88
 None
 0.82A 5ecoD-5jqhD:
undetectable		 5ecoD-5jqhD:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 114
GLU A  89
 None
 0.79A 5ecoD-5kn5A:
undetectable		 5ecoD-5kn5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbs BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8

(Homo sapiens) 		PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.78A 5ecoD-5lbsH:
undetectable		 5ecoD-5lbsH:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzv NANOBODY 22E11

(Lama glama) 		no annotation 4 ALA D  92
THR D  91
VAL D 119
GLU D  89
 None
 0.84A 5ecoD-5mzvD:
undetectable		 5ecoD-5mzvD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o02 NANOBODY (VHH)
NANO-4

(Vicugna pacos) 		PF07686
(V-set) 		4 ALA C  92
THR C  91
VAL C 120
GLU C  89
 None
 0.84A 5ecoD-5o02C:
undetectable		 5ecoD-5o02C:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocl ANTI-VGLUT NANOBODY

(Lama glama) 		PF07686
(V-set) 		4 ALA B  94
THR B  93
VAL B 122
GLU B  91
 None
 0.83A 5ecoD-5oclB:
undetectable		 5ecoD-5oclB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 4 ALA A 522
VAL A 526
TYR A 527
VAL A  89
 None
 0.81A 5ecoD-5odoA:
undetectable		 5ecoD-5odoA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td8 NANOBODY

(Vicugna pacos) 		PF07686
(V-set) 		4 ALA E  93
THR E  92
VAL E 124
GLU E  90
 None
 0.82A 5ecoD-5td8E:
undetectable		 5ecoD-5td8E:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th9 GS-5745 FAB HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  91
THR H  90
VAL H 111
GLU H  88
 None
 0.83A 5ecoD-5th9H:
undetectable		 5ecoD-5th9H:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjw NP-SPECIFIC
INHIBITORY VHH

(Vicugna pacos) 		PF07686
(V-set) 		4 ALA K  93
THR K  92
VAL K 120
GLU K  90
 None
 0.84A 5ecoD-5tjwK:
undetectable		 5ecoD-5tjwK:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 232
THR A 231
VAL A 106
VAL A  41
HIS A 233
 None
 1.26A 5ecoD-5uxnA:
undetectable		 5ecoD-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl2 T4 NANOBODY

(Lama glama) 		no annotation 4 ALA A  94
THR A  93
VAL A 122
GLU A  91
 None
 0.82A 5ecoD-5vl2A:
undetectable		 5ecoD-5vl2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxm SINGLE-DOMAIN
ANTIBODY 20IPAD

(Vicugna pacos) 		no annotation 4 ALA B  92
THR B  91
VAL B 121
GLU B  89
 None
 0.84A 5ecoD-5vxmB:
undetectable		 5ecoD-5vxmB:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcc VRC 315 02-1F07 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.67A 5ecoD-5wccH:
undetectable		 5ecoD-5wccH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.83A 5ecoD-5xcuA:
undetectable		 5ecoD-5xcuA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjm FABH

(Mus musculus) 		no annotation 4 ALA H  92
THR H  91
VAL H 116
GLU H  89
 None
 0.84A 5ecoD-5xjmH:
undetectable		 5ecoD-5xjmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9f HEAVY CHAIN OF FAB
FRAGMENT OF ANTIBODY
28F10

(Mus musculus) 		no annotation 4 ALA L  92
THR L  91
VAL L 119
GLU L  89
 None
 0.82A 5ecoD-5y9fL:
undetectable		 5ecoD-5y9fL:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yoy GOLIMUMAB HEAVY
CHAIN VARIABLE
REGION

(Homo sapiens) 		no annotation 4 ALA G  92
THR G  91
VAL G 122
GLU G  89
 None
 0.77A 5ecoD-5yoyG:
undetectable		 5ecoD-5yoyG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apo ANTI-MARBURGVIRUS
NUCLEOPROTEIN SINGLE
DOMAIN ANTIBODY A

(Lama glama) 		no annotation 4 ALA A  92
THR A  91
VAL A 114
GLU A  89
 None
 0.82A 5ecoD-6apoA:
undetectable		 5ecoD-6apoA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apq ANTI-MARBURGVIRUS
NUCLEOPROTEIN SINGLE
DOMAIN ANTIBODY B

(Lama glama) 		no annotation 4 ALA A  91
THR A  90
VAL A 114
GLU A  88
 None
 0.82A 5ecoD-6apqA:
undetectable		 5ecoD-6apqA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9j FAB VV138 HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 ALA H  92
THR H  91
VAL H 113
GLU H  89
 None
 0.81A 5ecoD-6b9jH:
undetectable		 5ecoD-6b9jH:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN

(Mus musculus) 		no annotation 4 ALA B 111
THR B 110
VAL B 135
GLU B 108
 None
 0.84A 5ecoD-6bpaB:
undetectable		 5ecoD-6bpaB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ey0 LLAMA NANOBODY NB01

(Lama glama) 		no annotation 4 ALA E  88
THR E  87
VAL E 109
GLU E  85
 None
 0.82A 5ecoD-6ey0E:
undetectable		 5ecoD-6ey0E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fxn BELIMUMAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 ALA D  92
THR D  91
VAL D 119
GLU D  89
 None
 0.80A 5ecoD-6fxnD:
undetectable		 5ecoD-6fxnD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama) 		no annotation 4 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.82A 5ecoD-6gzpA:
undetectable		 5ecoD-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 117
GLU B  89
 None
 0.82A 5ecoD-8fabB:
undetectable		 5ecoD-8fabB:
17.45