SIMILAR PATTERNS OF AMINO ACIDS FOR 5ECO_A_LEUA602_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a80 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE A

(Corynebacterium
sp.) 		PF00248
(Aldo_ket_red) 		4 THR A  46
ALA A  47
THR A  74
TYR A 105
 None
 0.95A 5ecoA-1a80A:
0.3		 5ecoA-1a80A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnd BRAIN DERIVED
NEUROTROPHIC FACTOR

(Homo sapiens) 		PF00243
(NGF) 		4 THR A  35
ALA A  28
THR A  27
VAL A  38
 None
 0.83A 5ecoA-1bndA:
undetectable		 5ecoA-1bndA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 ALA A  72
VAL A  70
TYR A  63
HIS A  47
 None
 0.87A 5ecoA-1ct9A:
undetectable		 5ecoA-1ct9A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5i DEACETOXYCEPHALOSPOR
IN C SYNTHASE

(Streptomyces
clavuligerus) 		PF03171
(2OG-FeII_Oxy) 		4 THR A 272
ALA A 292
THR A 291
VAL A 275
 None
 0.78A 5ecoA-1e5iA:
undetectable		 5ecoA-1e5iA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxm GAMMA-DELTA T-CELL
RECEPTOR

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR B  83
ALA B  19
THR B  18
VAL B  87
 None
 0.96A 5ecoA-1hxmB:
undetectable		 5ecoA-1hxmB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 THR A 132
ALA A 129
THR A 128
HIS A 236
 None
None
NAD  A1000 (-3.4A)
None
 1.00A 5ecoA-1mx3A:
2.5		 5ecoA-1mx3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 THR A  48
ALA A  49
THR A  76
TYR A 105
 None
 0.97A 5ecoA-1mzrA:
0.6		 5ecoA-1mzrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlr ENDO-1,4-BETA-GLUCAN
ASE

(Streptomyces
lividans) 		PF01670
(Glyco_hydro_12) 		4 THR A 147
ALA A 141
THR A 140
VAL A 150
 None
 0.92A 5ecoA-1nlrA:
undetectable		 5ecoA-1nlrA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1

(Caenorhabditis
elegans) 		PF00248
(Aldo_ket_red) 		4 THR A  48
ALA A  49
THR A  80
TYR A 111
 None
 1.02A 5ecoA-1qwkA:
1.6		 5ecoA-1qwkA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		4 THR A 483
ALA A 474
THR A 475
VAL A 453
 THR  A 483 ( 0.9A)
ALA  A 474 ( 0.0A)
THR  A 475 ( 0.9A)
VAL  A 453 ( 0.6A)
 0.74A 5ecoA-1v0fA:
undetectable		 5ecoA-1v0fA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		4 THR A  48
ALA A  49
THR A  76
TYR A 107
 None
 0.97A 5ecoA-1vbjA:
undetectable		 5ecoA-1vbjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcz RNASE NGR3

(Nicotiana
glutinosa) 		PF00445
(Ribonuclease_T2) 		4 THR A 179
ALA A 180
THR A 181
VAL A 176
 None
 0.94A 5ecoA-1vczA:
undetectable		 5ecoA-1vczA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		4 THR A  46
ALA A  47
THR A  78
TYR A 109
 None
 0.96A 5ecoA-1vp5A:
2.0		 5ecoA-1vp5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w66 LIPOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03099
(BPL_LplA_LipB) 		4 THR A  74
ALA A  55
THR A  54
VAL A  71
 None
 0.85A 5ecoA-1w66A:
undetectable		 5ecoA-1w66A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6f ZINC FINGER PROTEIN
462

(Homo sapiens) 		no annotation 4 THR A  42
ALA A  39
THR A  38
TYR A  26
 None
 0.86A 5ecoA-1x6fA:
undetectable		 5ecoA-1x6fA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 THR A 452
ALA A 442
THR A 441
VAL A 455
 152  A 613 (-2.7A)
None
152  A 613 (-2.8A)
None
 0.97A 5ecoA-1xl8A:
2.3		 5ecoA-1xl8A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwe COMPLEMENT C5

(Homo sapiens) 		PF01759
(NTR) 		4 THR A1548
ALA A1561
THR A1562
VAL A1545
 None
 0.92A 5ecoA-1xweA:
undetectable		 5ecoA-1xweA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edm 22KDA STRUCTURAL
PROTEIN VP22

(White spot
syndrome virus) 		PF12175
(WSS_VP) 		4 THR A 138
ALA A 183
THR A 184
VAL A 135
 None
 0.98A 5ecoA-2edmA:
undetectable		 5ecoA-2edmA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 4 THR H 337
ALA H 342
THR H 343
VAL H 334
 None
 0.83A 5ecoA-2fhgH:
undetectable		 5ecoA-2fhgH:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hms YUAA PROTEIN

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		4 THR A  50
ALA A  49
VAL A  22
HIS A  51
 None
 0.88A 5ecoA-2hmsA:
2.0		 5ecoA-2hmsA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jay PROTEASOME

(Mycobacterium
tuberculosis) 		PF00227
(Proteasome) 		4 THR A  94
ALA A  99
THR A 100
VAL A  91
 None
 0.86A 5ecoA-2jayA:
undetectable		 5ecoA-2jayA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jd4 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		5 THR A2946
ALA A2947
THR A2948
VAL A2983
HIS A2937
 None
 1.43A 5ecoA-2jd4A:
undetectable		 5ecoA-2jd4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6r HEAD-TO-TAIL JOINING
PROTEIN W (GPW) FROM
BACTERIOPHAGE ORIGIN

(Escherichia
virus Lambda) 		PF02831
(gpW) 		4 THR A  36
ALA A  37
THR A  38
VAL A  40
 None
 0.87A 5ecoA-2l6rA:
undetectable		 5ecoA-2l6rA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mev MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP2)

(Cardiovirus A) 		PF00073
(Rhv) 		4 THR 2  64
ALA 2 236
THR 2 235
VAL 2  67
 None
 1.01A 5ecoA-2mev2:
undetectable		 5ecoA-2mev2:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ome C-TERMINAL-BINDING
PROTEIN 2

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 THR A 138
ALA A 135
THR A 134
HIS A 242
 None
None
NAD  A 901 (-3.4A)
None
 0.99A 5ecoA-2omeA:
2.7		 5ecoA-2omeA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p18 GLYOXALASE II

(Leishmania
infantum) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 THR A  75
VAL A 144
TYR A 146
HIS A  81
 None
None
None
ZN  A 301 (-3.3A)
 1.00A 5ecoA-2p18A:
undetectable		 5ecoA-2p18A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r15 MYOMESIN-1

(Homo sapiens) 		PF07679
(I-set) 		4 THR A1593
ALA A1629
THR A1628
VAL A1596
 None
 1.02A 5ecoA-2r15A:
undetectable		 5ecoA-2r15A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq1 ANTI-HUMAN FC GAMMA
RECEPTOR III 3G8
GAMMA HEAVY CHAIN
VARIABLE REGION

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR B  87
ALA B  85
THR B  84
VAL B  83
 None
 0.99A 5ecoA-2vq1B:
undetectable		 5ecoA-2vq1B:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		4 THR A  54
ALA A  55
THR A  82
TYR A 113
 None
 0.98A 5ecoA-2wzmA:
undetectable		 5ecoA-2wzmA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.98A 5ecoA-2zj8A:
undetectable		 5ecoA-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 THR A 127
ALA A 157
THR A 156
VAL A 187
HIS A 125
 None
 1.47A 5ecoA-3b1bA:
undetectable		 5ecoA-3b1bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 175
ALA A 176
THR A 177
VAL A 180
 NAP  A 372 (-3.9A)
NAP  A 372 (-3.6A)
NAP  A 372 (-3.5A)
None
 0.62A 5ecoA-3b70A:
1.8		 5ecoA-3b70A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bem PUTATIVE NAD(P)H
NITROREDUCTASE YDFN

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		5 ALA A 135
THR A  47
VAL A  80
TYR A  49
HIS A  46
 None
 1.41A 5ecoA-3bemA:
undetectable		 5ecoA-3bemA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus) 		PF03372
(Exo_endo_phos) 		4 THR A 203
ALA A 204
THR A 205
HIS A 252
 CA  A 281 (-3.9A)
None
None
None
 0.86A 5ecoA-3dniA:
undetectable		 5ecoA-3dniA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es6 PROLACTIN-INDUCIBLE
PROTEIN

(Homo sapiens) 		PF05326
(SVA) 		4 ALA B  29
THR B  69
VAL B  27
TYR B  71
 None
 0.88A 5ecoA-3es6B:
undetectable		 5ecoA-3es6B:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7x PUTATIVE POLYKETIDE
CYCLASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		4 THR A   2
ALA A   3
THR A   4
VAL A   7
 None
 0.38A 5ecoA-3f7xA:
undetectable		 5ecoA-3f7xA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A 319
ALA A 318
THR A 317
VAL A 261
 NAD  A 601 (-4.1A)
None
None
None
 1.01A 5ecoA-3glqA:
2.7		 5ecoA-3glqA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG

(Helicobacter
pylori) 		PF00072
(Response_reg) 		4 ALA A  84
THR A  83
VAL A 104
TYR A 102
 SO4  A 126 (-3.1A)
SO4  A 126 (-3.7A)
None
None
 0.95A 5ecoA-3h1gA:
2.7		 5ecoA-3h1gA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 THR A  45
ALA A  32
THR A  31
VAL A  48
 None
 0.98A 5ecoA-3h7lA:
undetectable		 5ecoA-3h7lA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 THR A 484
ALA A 483
THR A 482
VAL A 396
 ADP  A 803 (-4.2A)
None
None
None
 0.89A 5ecoA-3k30A:
1.5		 5ecoA-3k30A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		4 ALA A 181
VAL A 178
TYR A 157
HIS A 182
 None
None
None
Z97  A 767 (-4.0A)
 1.00A 5ecoA-3koyA:
undetectable		 5ecoA-3koyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksp CALCIUM/CALMODULIN-D
EPENDENT KINASE II
ASSOCIATION DOMAIN

(Exiguobacterium
sibiricum) 		PF13474
(SnoaL_3) 		4 THR A  79
THR A  80
VAL A  76
HIS A 109
 None
 1.03A 5ecoA-3kspA:
undetectable		 5ecoA-3kspA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 THR A  51
ALA A  52
THR A  83
TYR A 114
 None
 1.00A 5ecoA-3ln3A:
undetectable		 5ecoA-3ln3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 THR A 182
ALA A 198
VAL A 279
TYR A 281
 None
 0.97A 5ecoA-3lppA:
undetectable		 5ecoA-3lppA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpc FN3-LIKE PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 THR A  60
ALA A  22
THR A  21
VAL A  64
 None
 0.98A 5ecoA-3mpcA:
undetectable		 5ecoA-3mpcA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0k ALDO/KETO REDUCTASE

(Brucella
abortus) 		PF00248
(Aldo_ket_red) 		4 THR A  65
ALA A  66
THR A  93
TYR A 124
 None
 1.02A 5ecoA-3o0kA:
2.0		 5ecoA-3o0kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p06 VP4 PROTEIN

(Tellina virus) 		no annotation 4 THR A 721
ALA A 722
THR A 723
VAL A 644
 None
 0.78A 5ecoA-3p06A:
undetectable		 5ecoA-3p06A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy3 THIOESTERASE

(Pseudomonas
aeruginosa) 		PF13279
(4HBT_2) 		4 ALA A  73
VAL A  75
TYR A  33
HIS A  71
 CL  A 201 (-3.9A)
None
None
None
 1.01A 5ecoA-3qy3A:
undetectable		 5ecoA-3qy3A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slg PBGP3 PROTEIN

(Burkholderia
pseudomallei) 		PF01370
(Epimerase) 		4 THR A  82
ALA A  84
THR A  85
VAL A  87
 None
None
None
CL  A 352 ( 4.6A)
 0.99A 5ecoA-3slgA:
undetectable		 5ecoA-3slgA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 THR A 841
ALA A 842
VAL A 846
TYR A 847
 None
 0.77A 5ecoA-3ummA:
2.6		 5ecoA-3ummA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		4 THR A 138
ALA A 139
THR A 140
VAL A 189
 None
 0.98A 5ecoA-3vmnA:
undetectable		 5ecoA-3vmnA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbx PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		4 THR A  54
ALA A  55
THR A  78
TYR A 109
 None
 0.98A 5ecoA-3wbxA:
undetectable		 5ecoA-3wbxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 THR A  54
ALA A  55
THR A  86
TYR A 117
 None
 0.99A 5ecoA-3wczA:
1.9		 5ecoA-3wczA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ALA A 721
THR A 722
VAL A 633
HIS A 695
 None
EDO  A2290 (-3.1A)
None
None
 0.99A 5ecoA-4a4zA:
undetectable		 5ecoA-4a4zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 THR A1566
ALA A1579
THR A1580
VAL A1563
 None
 0.97A 5ecoA-4a5wA:
undetectable		 5ecoA-4a5wA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 THR A 203
ALA A 204
THR A 205
HIS A 252
 CA  A 301 (-3.7A)
None
None
PO4  A 310 (-4.1A)
 0.90A 5ecoA-4awnA:
undetectable		 5ecoA-4awnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 THR A 191
ALA A 137
VAL A 139
TYR A 140
 None
 0.82A 5ecoA-4c7oA:
2.5		 5ecoA-4c7oA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 THR B 120
ALA B 140
THR B 139
VAL B 123
 None
 0.98A 5ecoA-4ci2B:
undetectable		 5ecoA-4ci2B:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR

(Proteus
mirabilis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 THR A 126
THR A 128
VAL A 131
TYR A 132
 None
 0.93A 5ecoA-4d5cA:
undetectable		 5ecoA-4d5cA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzg PLIG

(Aeromonas
hydrophila) 		no annotation 4 THR A  26
THR A  53
VAL A  29
HIS A  51
 None
MLY  A 107 ( 4.0A)
None
None
 0.92A 5ecoA-4dzgA:
undetectable		 5ecoA-4dzgA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		4 ALA A 276
THR A 275
VAL A 253
HIS A 277
 None
 0.93A 5ecoA-4f0sA:
undetectable		 5ecoA-4f0sA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE

(Leishmania
major) 		PF00248
(Aldo_ket_red) 		4 THR A  50
ALA A  51
THR A  78
TYR A 109
 None
 0.98A 5ecoA-4f40A:
2.2		 5ecoA-4f40A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		4 THR A  49
ALA A  50
THR A  77
TYR A 108
 None
 0.96A 5ecoA-4fziA:
2.0		 5ecoA-4fziA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.67A 5ecoA-4g1pA:
2.4		 5ecoA-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 THR N 196
VAL N 199
TYR N 200
HIS N 193
 None
 0.97A 5ecoA-4heaN:
undetectable		 5ecoA-4heaN:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hns CHEMOTAXIS PROTEIN
CHEY

(Vibrio cholerae) 		PF00072
(Response_reg) 		4 ALA A  91
THR A  90
VAL A 111
TYR A 109
 BEF  A 202 (-3.8A)
BEF  A 202 (-3.4A)
None
None
 0.92A 5ecoA-4hnsA:
2.9		 5ecoA-4hnsA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzh PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 THR A 186
THR A 185
VAL A 184
HIS A 187
 None
 0.93A 5ecoA-4hzhA:
undetectable		 5ecoA-4hzhA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 5 THR A 771
ALA A 773
THR A 774
VAL A 777
TYR A 778
 None
 1.31A 5ecoA-4jzaA:
undetectable		 5ecoA-4jzaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00884
(Sulfatase) 		4 THR A 411
ALA A 413
THR A 414
VAL A 416
 None
 0.94A 5ecoA-4kavA:
undetectable		 5ecoA-4kavA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		4 THR A  28
ALA A  11
THR A  10
VAL A  31
 None
 0.97A 5ecoA-4kemA:
3.0		 5ecoA-4kemA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 ALA A 493
THR A 494
VAL A 499
TYR A 500
 None
 0.65A 5ecoA-4kf7A:
undetectable		 5ecoA-4kf7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhb PUTATIVE ALDO/KETO
REDUCTASE

(Yersinia pestis) 		PF00248
(Aldo_ket_red) 		4 THR A  59
ALA A  60
THR A  87
TYR A 118
 None
 0.97A 5ecoA-4mhbA:
undetectable		 5ecoA-4mhbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 THR A 130
ALA A 131
THR A 132
VAL A 126
 None
 0.84A 5ecoA-4nz0A:
undetectable		 5ecoA-4nz0A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 THR A  53
ALA A  54
THR A  81
TYR A 112
 None
 1.02A 5ecoA-4otkA:
undetectable		 5ecoA-4otkA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3m MGS-M4

(unidentified) 		PF00248
(Aldo_ket_red) 		4 THR A  44
ALA A  45
THR A  72
TYR A 103
 None
 0.95A 5ecoA-4q3mA:
1.7		 5ecoA-4q3mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qo5 HYPOTHETICAL
MULTIHEME PROTEIN

(Ignicoccus
hospitalis) 		PF13435
(Cytochrome_C554)
PF13447
(Multi-haem_cyto) 		4 THR A 244
ALA A 245
TYR A 149
HIS A 229
 HEC  A 602 ( 2.7A)
HEC  A 606 (-3.8A)
HEC  A 605 (-4.1A)
HEC  A 602 (-4.3A)
 0.88A 5ecoA-4qo5A:
undetectable		 5ecoA-4qo5A:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdq BESTROPHIN-1

(Gallus gallus) 		PF01062
(Bestrophin) 		4 THR A 348
ALA A 350
THR A 351
TYR A 354
 None
 0.98A 5ecoA-4rdqA:
undetectable		 5ecoA-4rdqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR

(Klebsiella
pneumoniae) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 ALA A  80
THR A  79
VAL A 100
TYR A  98
 BEF  A 301 (-3.5A)
BEF  A 301 (-3.7A)
None
None
 0.94A 5ecoA-4s05A:
2.4		 5ecoA-4s05A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6t COLH PROTEIN

(Hathewaya
histolytica) 		PF00801
(PKD) 		4 THR A 745
ALA A 766
THR A 765
VAL A 748
 None
 0.85A 5ecoA-4u6tA:
undetectable		 5ecoA-4u6tA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		4 ALA A 372
THR A 373
VAL A 367
TYR A 366
 None
 0.99A 5ecoA-4wmjA:
undetectable		 5ecoA-4wmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 ALA A 328
VAL A 331
TYR A 332
HIS A 438
 40V  A1001 ( 4.6A)
None
40V  A1001 (-3.8A)
40V  A1001 (-3.6A)
 0.93A 5ecoA-4xiiA:
undetectable		 5ecoA-4xiiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z66 HISTONE H4

(Xenopus laevis) 		PF15511
(CENP-T_C) 		4 THR B  82
ALA B  83
VAL B  87
TYR B  88
 None
 0.87A 5ecoA-4z66B:
undetectable		 5ecoA-4z66B:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zte CADHERIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		4 THR A 188
ALA A 207
THR A 206
VAL A 191
 None
 0.97A 5ecoA-4zteA:
undetectable		 5ecoA-4zteA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chl HISTONE H2A.Z

(Homo sapiens) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		4 THR B 123
ALA B 124
THR B  59
VAL B 120
 None
 1.02A 5ecoA-5chlB:
undetectable		 5ecoA-5chlB:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		6 THR A 164
ALA A 165
THR A 166
VAL A 169
TYR A 170
HIS A 534
 LEU  A 602 (-4.7A)
LEU  A 602 (-3.1A)
LEU  A 602 ( 3.0A)
LEU  A 602 (-4.6A)
LEU  A 602 (-4.4A)
LEU  A 602 (-4.9A)
 0.03A 5ecoA-5ecoA:
72.2		 5ecoA-5ecoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee4 HPUA

(Kingella
denitrificans) 		PF16960
(HpuA) 		4 THR A 257
ALA A 251
THR A 250
VAL A 260
 None
 0.86A 5ecoA-5ee4A:
undetectable		 5ecoA-5ee4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		4 THR A 411
ALA A 413
THR A 414
VAL A 416
 None
 1.02A 5ecoA-5fgnA:
undetectable		 5ecoA-5fgnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 ALA A 186
THR A 187
VAL A 193
HIS A 185
 None
 0.94A 5ecoA-5husA:
undetectable		 5ecoA-5husA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 THR Z 119
ALA Z 139
THR Z 138
VAL Z 122
 None
 0.94A 5ecoA-5hxbZ:
undetectable		 5ecoA-5hxbZ:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlu ADHESIN COMPETENCE
REPRESSOR

(Streptococcus
pyogenes) 		PF01047
(MarR) 		4 THR A 115
VAL A 118
TYR A 119
HIS A 111
 None
 0.92A 5ecoA-5jluA:
undetectable		 5ecoA-5jluA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ket ALDO-KETO REDUCTASE
1

(Coptotermes
gestroi) 		PF00248
(Aldo_ket_red) 		4 THR A  48
ALA A  49
THR A  80
TYR A 111
 None
 0.94A 5ecoA-5ketA:
1.9		 5ecoA-5ketA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgn REST COREPRESSOR 1

(Homo sapiens) 		PF00249
(Myb_DNA-binding) 		4 THR B 329
ALA B 331
THR B 332
VAL B 334
 None
 0.99A 5ecoA-5lgnB:
undetectable		 5ecoA-5lgnB:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n40 PUTATIVE INVASIN

(Yersinia
pseudotuberculosis) 		PF05689
(DUF823)
PF09134
(Invasin_D3) 		4 THR A2541
ALA A2524
THR A2523
VAL A2544
 None
 0.99A 5ecoA-5n40A:
undetectable		 5ecoA-5n40A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvd CBS-CP12

(Microcystis
aeruginosa) 		no annotation 4 THR A  54
THR A  56
VAL A  59
TYR A  60
 None
 0.74A 5ecoA-5nvdA:
undetectable		 5ecoA-5nvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		5 ALA A 413
THR A 412
VAL A 415
TYR A 288
HIS A 410
 None
 1.36A 5ecoA-5te1A:
3.3		 5ecoA-5te1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 THR M 340
VAL M 343
TYR M 344
HIS M 382
 None
 0.83A 5ecoA-5wc8M:
1.6		 5ecoA-5wc8M:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a70 -

(-) 		no annotation 4 ALA B3865
THR B3855
VAL B3867
HIS B3864
 None
 0.99A 5ecoA-6a70B:
undetectable		 5ecoA-6a70B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0w HISTONE H4

(Homo sapiens) 		no annotation 4 THR B  82
ALA B  83
VAL B  87
TYR B  88
 THR  B  82 ( 0.8A)
ALA  B  83 ( 0.0A)
VAL  B  87 ( 0.6A)
TYR  B  88 ( 1.3A)
 0.82A 5ecoA-6c0wB:
undetectable		 5ecoA-6c0wB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 4 THR A 115
ALA A 116
THR A 117
VAL A  41
 None
 1.00A 5ecoA-6d6kA:
undetectable		 5ecoA-6d6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 4 THR A 242
ALA A 144
THR A 143
VAL A 245
 None
 0.89A 5ecoA-6eo5A:
undetectable		 5ecoA-6eo5A:
undetectable