SIMILAR PATTERNS OF AMINO ACIDS FOR 5ECN_D_LEUD602_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4k ANTIBODY FAB

(Mus musculus) 		no annotation 4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.75A 5ecnD-1a4kH:
undetectable		 5ecnD-1a4kH:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		4 ALA A 272
TYR A 265
VAL A  37
GLU A  38
 None
 0.89A 5ecnD-1aj8A:
undetectable		 5ecnD-1aj8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 ALA A 362
THR A 363
VAL A 366
TYR A 367
 None
 0.74A 5ecnD-1aqlA:
1.2		 5ecnD-1aqlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 ILE A   9
ALA A 451
VAL A 453
VAL A   7
 PC1  A 777 (-3.9A)
None
None
PC1  A 777 (-4.6A)
 0.89A 5ecnD-1bp1A:
1.9		 5ecnD-1bp1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 ALA A 333
THR A 334
VAL A  18
VAL A 296
 None
 0.80A 5ecnD-1bwdA:
0.0		 5ecnD-1bwdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		4 ILE A  78
ALA A 301
VAL A 304
HIS A  70
 None
 0.87A 5ecnD-1c9eA:
undetectable		 5ecnD-1c9eA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 236
ALA A  17
THR A  18
VAL A 224
 None
 0.89A 5ecnD-1d6hA:
0.0		 5ecnD-1d6hA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1duw NONAHEME CYTOCHROME
C

(Desulfovibrio
desulfuricans) 		PF02085
(Cytochrom_CIII) 		4 THR A  64
VAL A  19
GLU A  70
HIS A  63
 None
None
None
HEM  A 293 (-3.4A)
 0.88A 5ecnD-1duwA:
undetectable		 5ecnD-1duwA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 241
ALA A  22
THR A  23
VAL A 229
 None
 0.88A 5ecnD-1ee0A:
0.0		 5ecnD-1ee0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fj1 HYBRIDOMA ANTIBODY
LA2 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 109
GLU B  89
 None
 0.69A 5ecnD-1fj1B:
undetectable		 5ecnD-1fj1B:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 ILE A 259
VAL A 289
TYR A 290
VAL A 261
 None
 0.86A 5ecnD-1g68A:
undetectable		 5ecnD-1g68A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 ILE D 694
THR D 662
GLU D 668
HIS D 667
 None
None
None
ZN  D 709 (-3.2A)
 0.89A 5ecnD-1hqrD:
undetectable		 5ecnD-1hqrD:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		4 ILE A 250
ALA A 282
THR A 283
VAL A 286
 None
 0.85A 5ecnD-1i2wA:
undetectable		 5ecnD-1i2wA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 ILE A 533
ALA A 501
VAL A 553
TYR A 535
 None
 0.81A 5ecnD-1iduA:
undetectable		 5ecnD-1iduA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osc SIMILAR TO DIVALENT
CATION TOLERANT
PROTEIN CUTA

(Rattus
norvegicus) 		PF03091
(CutA1) 		4 ILE A  27
ALA A  14
VAL A  91
VAL A  31
 None
 0.76A 5ecnD-1oscA:
undetectable		 5ecnD-1oscA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		4 ILE A  85
ALA A 228
VAL A  88
VAL A  15
 None
 0.89A 5ecnD-1pk9A:
undetectable		 5ecnD-1pk9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		5 ILE A  23
THR A  47
VAL A  38
TYR A  49
GLU A  13
 None
 1.38A 5ecnD-1qd1A:
undetectable		 5ecnD-1qd1A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle HEAVY CHAIN ANTIBODY
FV FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 114
GLU H  89
 None
 0.71A 5ecnD-1qleH:
undetectable		 5ecnD-1qleH:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1quq PROTEIN (REPLICATION
PROTEIN A 14 KD
SUBUNIT)

(Homo sapiens) 		PF08661
(Rep_fac-A_3) 		4 ILE B  53
ALA B  77
THR B  78
VAL B  73
 None
 0.88A 5ecnD-1quqB:
undetectable		 5ecnD-1quqB:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 ALA A 371
THR A 370
VAL A 383
VAL A 649
 None
 0.77A 5ecnD-1qxpA:
undetectable		 5ecnD-1qxpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rr9 ATP-DEPENDENT
PROTEASE LA

(Escherichia
coli) 		PF05362
(Lon_C) 		4 ILE A 664
ALA A 641
VAL A 645
VAL A 666
 None
 0.79A 5ecnD-1rr9A:
undetectable		 5ecnD-1rr9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taf TFIID TBP ASSOCIATED
FACTOR 42
TFIID TBP ASSOCIATED
FACTOR 62

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF02291
(TFIID-31kDa)
PF02969
(TAF) 		5 ILE A  56
ALA B  33
VAL B  36
TYR A  52
VAL A  77
 None
 1.48A 5ecnD-1tafA:
undetectable		 5ecnD-1tafA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		4 ILE A  63
ALA A 118
VAL A 121
HIS A  20
 None
 0.74A 5ecnD-1taqA:
undetectable		 5ecnD-1taqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ALA A 185
THR A 186
VAL A 189
VAL A 249
 ALA  A 185 ( 0.0A)
THR  A 186 ( 0.8A)
VAL  A 189 ( 0.6A)
VAL  A 249 ( 0.6A)
 0.79A 5ecnD-1tedA:
undetectable		 5ecnD-1tedA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp2 PUTATIVE XANTHOSINE
TRIPHOSPHATE
PYROPHOSPHATASE/HAM1
PROTEIN HOMOLOG

(Thermotoga
maritima) 		PF01725
(Ham1p_like) 		4 ILE A  36
ALA A  66
VAL A  64
VAL A  38
 None
 0.66A 5ecnD-1vp2A:
undetectable		 5ecnD-1vp2A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf0 TAR DNA-BINDING
PROTEIN-43

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  72
ALA A  45
VAL A  47
VAL A  70
 None
 0.87A 5ecnD-1wf0A:
undetectable		 5ecnD-1wf0A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 ILE A 120
ALA A  11
VAL A  13
VAL A 118
 None
 0.90A 5ecnD-1wf3A:
4.9		 5ecnD-1wf3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xk8 DIVALENT CATION
TOLERANT PROTEIN
CUTA

(Homo sapiens) 		PF03091
(CutA1) 		4 ILE A  61
ALA A  48
VAL A 125
VAL A  65
 None
 0.72A 5ecnD-1xk8A:
undetectable		 5ecnD-1xk8A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		4 ILE A  53
ALA A  36
VAL A  32
VAL A 131
 None
 0.80A 5ecnD-1z9dA:
undetectable		 5ecnD-1z9dA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxx 6-PHOSPHOFRUCTOKINAS
E

(Lactobacillus
delbrueckii) 		PF00365
(PFK) 		4 ILE A   4
ALA A  22
VAL A  26
VAL A  98
 None
 0.83A 5ecnD-1zxxA:
undetectable		 5ecnD-1zxxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		4 ALA A 285
THR A 326
VAL A 283
TYR A 328
 None
None
None
ODT  A1001 ( 4.0A)
 0.87A 5ecnD-2bacA:
undetectable		 5ecnD-2bacA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c21 TRYPANOTHIONE-DEPEND
ENT GLYOXALASE I

(Leishmania
major) 		PF00903
(Glyoxalase) 		4 ILE A  80
ALA A 109
VAL A 111
VAL A  82
 None
 0.67A 5ecnD-2c21A:
undetectable		 5ecnD-2c21A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxx PROBABLE GTP-BINDING
PROTEIN ENGB

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1) 		4 ILE A   5
ALA A   2
THR A   3
HIS A  46
 None
 0.90A 5ecnD-2cxxA:
1.5		 5ecnD-2cxxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwr OUTER CAPSID PROTEIN

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		5 ILE A 166
THR A 103
VAL A 105
TYR A  93
VAL A 173
 None
 1.37A 5ecnD-2dwrA:
undetectable		 5ecnD-2dwrA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.53A 5ecnD-2ejvA:
undetectable		 5ecnD-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb0 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03992
(ABM) 		4 ILE A  52
ALA A  27
THR A  26
TYR A  38
 None
None
None
ACT  A 901 (-4.7A)
 0.83A 5ecnD-2fb0A:
undetectable		 5ecnD-2fb0A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD) 		4 ILE A 116
ALA A 103
VAL A 180
VAL A 120
 None
 0.68A 5ecnD-2g9nA:
undetectable		 5ecnD-2g9nA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1

(Mus musculus) 		PF00300
(His_Phos_1) 		5 ILE A 549
ALA A 564
VAL A 377
VAL A 545
GLU A 485
 None
 1.33A 5ecnD-2h0qA:
undetectable		 5ecnD-2h0qA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		5 ILE A 161
ALA A  96
THR A  97
VAL A 100
HIS A  94
 None
 1.13A 5ecnD-2ibpA:
undetectable		 5ecnD-2ibpA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		5 ILE A 168
ALA A 180
THR A 181
VAL A 446
HIS A 419
 None
None
None
FAD  A1466 (-4.2A)
None
 1.41A 5ecnD-2ivdA:
undetectable		 5ecnD-2ivdA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1

(Mus musculus) 		PF04099
(Sybindin) 		5 ILE C  80
ALA C 103
VAL C 106
VAL C  82
HIS C  99
 None
 1.49A 5ecnD-2j3tC:
undetectable		 5ecnD-2j3tC:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8a ENDOGLUCANASE

(Bacillus
subtilis) 		PF00942
(CBM_3) 		4 ILE A 354
ALA A 391
VAL A 389
VAL A 356
 None
 0.72A 5ecnD-2l8aA:
undetectable		 5ecnD-2l8aA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
megaterium;
Bacillus
megaterium) 		PF13377
(Peripla_BP_3)
PF00381
(PTS-HPr) 		4 ILE G  85
ALA L  19
THR L  20
VAL L  23
 None
 0.75A 5ecnD-2nzuG:
2.5		 5ecnD-2nzuG:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p25 GLYOXALASE FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00903
(Glyoxalase) 		4 ILE A  11
ALA A  18
THR A  19
TYR A  23
 None
 0.62A 5ecnD-2p25A:
undetectable		 5ecnD-2p25A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		4 ILE A  72
ALA A  89
VAL A  93
VAL A  11
 None
 0.83A 5ecnD-2qq1A:
undetectable		 5ecnD-2qq1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		4 ILE A 261
ALA A 197
VAL A 200
VAL A 259
 None
 0.85A 5ecnD-2qr6A:
undetectable		 5ecnD-2qr6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 376
THR A 375
VAL A 378
VAL A  76
 None
 0.87A 5ecnD-2vd5A:
undetectable		 5ecnD-2vd5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
aureus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 ILE A 430
ALA A 436
THR A 437
GLU A 433
 None
 0.86A 5ecnD-2wqdA:
undetectable		 5ecnD-2wqdA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 ILE A 371
ALA A 395
VAL A 393
VAL A 373
 None
 0.87A 5ecnD-2x5fA:
2.2		 5ecnD-2x5fA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA

(Rattus
norvegicus;
Homo sapiens) 		PF01602
(Adaptin_N)
PF01602
(Adaptin_N) 		5 ALA B 487
THR B 486
VAL B 489
TYR B 526
GLU A 575
 None
 1.49A 5ecnD-2xa7B:
undetectable		 5ecnD-2xa7B:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 ALA A 246
THR A 247
VAL A 250
VAL A 315
 None
 0.86A 5ecnD-2yijA:
undetectable		 5ecnD-2yijA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Escherichia
coli) 		PF13360
(PQQ_2) 		4 ALA A 133
VAL A 131
VAL A 157
HIS A 121
 None
 0.62A 5ecnD-2ymsA:
undetectable		 5ecnD-2ymsA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Escherichia
coli) 		PF13360
(PQQ_2) 		4 ALA B 133
VAL B 131
VAL B 157
HIS B 121
 None
 0.62A 5ecnD-2ymsB:
undetectable		 5ecnD-2ymsB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.61A 5ecnD-2z8eA:
undetectable		 5ecnD-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfh CUTA

(Homo sapiens) 		PF03091
(CutA1) 		4 ILE A  84
ALA A  71
VAL A 148
VAL A  88
 None
 0.74A 5ecnD-2zfhA:
undetectable		 5ecnD-2zfhA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 116
ALA A 103
VAL A 180
VAL A 120
 None
 0.60A 5ecnD-2zu6A:
2.3		 5ecnD-2zu6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 ILE A  51
TYR A 463
VAL A  53
HIS A 274
 None
 0.71A 5ecnD-3a21A:
1.4		 5ecnD-3a21A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a77 INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		5 ALA A 374
VAL A 376
VAL A 368
GLU A 205
HIS A 394
 None
 1.39A 5ecnD-3a77A:
undetectable		 5ecnD-3a77A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		PF01425
(Amidase)
PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		4 ALA A 293
THR A 294
VAL A 297
VAL C  45
 None
 0.75A 5ecnD-3al0A:
undetectable		 5ecnD-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Saccharomyces
cerevisiae) 		PF01408
(GFO_IDH_MocA) 		4 ILE A 147
ALA A 139
VAL A 144
VAL A 121
 None
 0.80A 5ecnD-3btuA:
undetectable		 5ecnD-3btuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5y RIBOSE/GALACTOSE
ISOMERASE

(Novosphingobium
aromaticivorans) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		4 ILE A   3
ALA A  21
VAL A  25
VAL A  69
 None
 0.60A 5ecnD-3c5yA:
undetectable		 5ecnD-3c5yA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 ILE A 448
ALA A  58
VAL A  56
VAL A 143
 None
 0.90A 5ecnD-3e74A:
undetectable		 5ecnD-3e74A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es6 PROLACTIN-INDUCIBLE
PROTEIN

(Homo sapiens) 		PF05326
(SVA) 		4 ALA B  29
THR B  69
VAL B  27
TYR B  71
 None
 0.73A 5ecnD-3es6B:
undetectable		 5ecnD-3es6B:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f43 PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1081

(Thermotoga
maritima) 		PF01740
(STAS) 		5 ILE A  53
ALA A  24
VAL A  60
VAL A  50
GLU A  18
 None
 1.44A 5ecnD-3f43A:
undetectable		 5ecnD-3f43A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE

(Salmonella
enterica) 		PF00215
(OMPdecase) 		4 ILE A 147
ALA A 165
TYR A 176
HIS A 134
 None
MLI  A 300 ( 4.2A)
None
MLI  A 300 (-4.1A)
 0.81A 5ecnD-3f4wA:
undetectable		 5ecnD-3f4wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 994
ALA A 960
VAL A 997
HIS A 953
 None
ACY  A2201 ( 3.8A)
ACY  A2203 (-4.5A)
ACY  A2201 (-3.9A)
 0.88A 5ecnD-3fg4A:
undetectable		 5ecnD-3fg4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fho ATP-DEPENDENT RNA
HELICASE DBP5

(Schizosaccharomyces
pombe) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 200
ALA A 187
VAL A 259
VAL A 204
 None
 0.84A 5ecnD-3fhoA:
undetectable		 5ecnD-3fhoA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 220
ALA A 190
VAL A 194
HIS A 174
 None
None
None
FAD  A   1 (-3.9A)
 0.89A 5ecnD-3fw8A:
undetectable		 5ecnD-3fw8A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A  56
ALA A  17
VAL A  13
VAL A  39
 None
 0.89A 5ecnD-3gvxA:
3.1		 5ecnD-3gvxA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ILE B 152
ALA B 433
VAL B 414
VAL B 150
 None
 0.86A 5ecnD-3h0gB:
undetectable		 5ecnD-3h0gB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		4 ALA A  15
THR A  16
VAL A  19
VAL A  61
 None
 0.79A 5ecnD-3h4yA:
undetectable		 5ecnD-3h4yA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 ILE A 235
VAL A 627
TYR A 628
VAL A 231
 None
 0.90A 5ecnD-3i04A:
undetectable		 5ecnD-3i04A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG4930

(Drosophila
melanogaster) 		PF08785
(Ku_PK_bind) 		4 ALA C  63
THR C  62
TYR C  25
VAL C  44
 None
 0.66A 5ecnD-3ismC:
undetectable		 5ecnD-3ismC:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j40 GP7

(Salmonella
virus Epsilon15) 		no annotation 4 ILE A  37
ALA A  41
THR A  39
VAL A 125
 None
 0.86A 5ecnD-3j40A:
undetectable		 5ecnD-3j40A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 125
THR A 126
VAL A 129
VAL A 157
 None
 0.72A 5ecnD-3k17A:
undetectable		 5ecnD-3k17A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		4 ILE A 474
ALA A 487
VAL A 491
VAL A 476
 None
 0.80A 5ecnD-3k1jA:
undetectable		 5ecnD-3k1jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL) 		4 ILE B  44
ALA B  76
VAL B  80
VAL B  22
 None
 0.79A 5ecnD-3kydB:
undetectable		 5ecnD-3kydB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		4 ILE A 262
ALA A 294
THR A 295
VAL A 298
 None
 0.82A 5ecnD-3lezA:
undetectable		 5ecnD-3lezA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		4 ILE A 111
ALA A 205
VAL A 209
VAL A  32
 None
 0.90A 5ecnD-3lgsA:
0.4		 5ecnD-3lgsA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mk3 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Salmonella
enterica) 		no annotation 4 ILE A  49
ALA A  75
VAL A  77
VAL A  44
 None
 0.73A 5ecnD-3mk3A:
undetectable		 5ecnD-3mk3A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
EPSILON

(Bos taurus) 		PF04733
(Coatomer_E) 		4 ALA A 185
THR A 186
VAL A 189
GLU A 177
 None
 0.47A 5ecnD-3mkrA:
undetectable		 5ecnD-3mkrA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ILE A 397
ALA A 418
VAL A 423
TYR A 425
 None
 0.87A 5ecnD-3mogA:
undetectable		 5ecnD-3mogA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		4 ALA A 148
VAL A 144
VAL A 163
GLU A 158
 None
 0.90A 5ecnD-3msuA:
undetectable		 5ecnD-3msuA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne2 PROBABLE AQUAPORIN
AQPM

(Archaeoglobus
fulgidus) 		PF00230
(MIP) 		4 ILE A 180
ALA A  66
VAL A  70
VAL A 184
 None
 0.85A 5ecnD-3ne2A:
undetectable		 5ecnD-3ne2A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3)
no annotation 		4 ILE A  86
ALA S  19
THR S  20
VAL S  23
 None
None
None
SEP  S  46 ( 4.4A)
 0.73A 5ecnD-3oqnA:
1.9		 5ecnD-3oqnA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q54 OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Escherichia
coli) 		PF13360
(PQQ_2) 		4 ALA A 133
VAL A 131
VAL A 157
HIS A 121
 None
 0.64A 5ecnD-3q54A:
undetectable		 5ecnD-3q54A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 ILE A 126
ALA A  41
VAL A  43
VAL A 124
 None
 0.87A 5ecnD-3qbdA:
2.3		 5ecnD-3qbdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvl PUTATIVE HYDANTOIN
RACEMASE

(Klebsiella
pneumoniae) 		PF01177
(Asp_Glu_race) 		4 ILE A   6
ALA A  24
VAL A  28
VAL A  76
 None
 0.82A 5ecnD-3qvlA:
undetectable		 5ecnD-3qvlA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 196
ALA A 183
VAL A 265
VAL A 200
 None
 0.75A 5ecnD-3sqwA:
0.9		 5ecnD-3sqwA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1

(Burkholderia
ambifaria) 		PF00793
(DAHP_synth_1) 		4 ALA A 199
THR A 200
VAL A 203
VAL A 254
 None
 0.83A 5ecnD-3t4cA:
undetectable		 5ecnD-3t4cA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 401
ALA A 360
VAL A 362
VAL A 454
 None
 0.90A 5ecnD-3urhA:
undetectable		 5ecnD-3urhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ILE A 356
ALA A 366
THR A 367
VAL A 370
 None
 0.60A 5ecnD-3wfoA:
undetectable		 5ecnD-3wfoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ILE A 356
ALA A 366
THR A 367
VAL A 370
 None
 0.58A 5ecnD-3wfpA:
undetectable		 5ecnD-3wfpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiw GLYCOSYL HYDROLASE
FAMILY 88

(Pedobacter
heparinus) 		PF07470
(Glyco_hydro_88) 		4 ALA A 315
VAL A 311
TYR A 380
GLU A 180
 None
 0.84A 5ecnD-3wiwA:
undetectable		 5ecnD-3wiwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		4 ILE A 263
ALA A 112
THR A 113
VAL A 116
 None
 0.85A 5ecnD-4c3oA:
undetectable		 5ecnD-4c3oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 206
ALA A 176
VAL A 180
HIS A 160
 None
None
None
FAD  A 501 (-3.9A)
 0.88A 5ecnD-4dnsA:
undetectable		 5ecnD-4dnsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex6 ALNB

(Streptomyces
sp. CM020) 		PF13419
(HAD_2) 		4 ALA A  32
THR A  31
TYR A  79
VAL A  51
 BO3  A 302 (-3.3A)
None
None
None
 0.87A 5ecnD-4ex6A:
undetectable		 5ecnD-4ex6A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 ALA A 507
THR A 508
VAL A 511
GLU A 501
 None
 0.68A 5ecnD-4f7zA:
undetectable		 5ecnD-4f7zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ALA A 736
THR A 737
VAL A 742
VAL A 789
 None
 0.88A 5ecnD-4fgvA:
undetectable		 5ecnD-4fgvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.49A 5ecnD-4g1pA:
undetectable		 5ecnD-4g1pA:
21.32