SIMILAR PATTERNS OF AMINO ACIDS FOR 5ECN_A_LEUA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR

(Homo sapiens) 		PF01858
(RB_A) 		4 ALA A 496
THR A 497
GLU A 545
HIS A 549
 None
 1.22A 5ecnA-1ad6A:
undetectable		 5ecnA-1ad6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		4 ALA A 272
TYR A 265
VAL A  37
GLU A  38
 None
 1.02A 5ecnA-1aj8A:
undetectable		 5ecnA-1aj8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE

(Nostoc sp. PCC
7120) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ALA A  38
THR A  35
VAL A 107
HIS A 114
 None
 1.01A 5ecnA-1gv3A:
undetectable		 5ecnA-1gv3A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 266
THR A 267
TYR A 270
VAL A 219
 NAJ  A1361 ( 4.1A)
NAJ  A1361 (-4.6A)
None
NAJ  A1361 (-4.4A)
 0.83A 5ecnA-1h2bA:
0.5		 5ecnA-1h2bA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 VAL A 158
LYS A 144
GLU A 143
HIS A 145
 None
 1.04A 5ecnA-1itzA:
0.8		 5ecnA-1itzA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		4 ALA A  35
VAL A 168
LYS A 163
HIS A 161
 None
 1.01A 5ecnA-1j5sA:
0.1		 5ecnA-1j5sA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		4 ALA A  92
THR A 118
LYS A 112
HIS A 116
 None
 1.22A 5ecnA-1j5xA:
1.0		 5ecnA-1j5xA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A 102
THR A 101
VAL A 310
HIS A 134
 None
 1.11A 5ecnA-1mldA:
0.1		 5ecnA-1mldA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		4 ALA A 313
TYR A  93
VAL A 290
HIS A 308
 None
 1.09A 5ecnA-1vl4A:
undetectable		 5ecnA-1vl4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z INTERCELLULAR
ADHESION MOLECULE-1

(Homo sapiens) 		PF03921
(ICAM_N) 		4 ALA I 155
TYR I 180
VAL I 148
HIS I 153
 None
 1.19A 5ecnA-1z7zI:
undetectable		 5ecnA-1z7zI:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Homo sapiens) 		PF00551
(Formyl_trans_N) 		4 ALA A 120
VAL A 169
GLU A 173
HIS A 108
 None
None
GRF  A1300 (-2.8A)
None
 1.06A 5ecnA-1zlyA:
undetectable		 5ecnA-1zlyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ALA A 134
THR A 135
VAL A 175
HIS A 137
 None
 1.24A 5ecnA-2ag1A:
undetectable		 5ecnA-2ag1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axq SACCHAROPINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 ALA A 133
THR A 136
GLU A 442
HIS A 361
 None
 1.22A 5ecnA-2axqA:
undetectable		 5ecnA-2axqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egu CYSTEINE SYNTHASE

(Geobacillus
kaustophilus) 		PF00291
(PALP) 		4 ALA A 186
THR A 158
VAL A  44
GLU A  36
 None
 1.23A 5ecnA-2eguA:
undetectable		 5ecnA-2eguA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		4 ALA A 389
THR A 386
VAL A 370
LYS A 463
 None
 1.05A 5ecnA-2epgA:
undetectable		 5ecnA-2epgA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf9 RAS-RELATED PROTEIN
RAB-3D

(Homo sapiens) 		PF00071
(Ras) 		4 ALA A  90
THR A  89
TYR A  92
GLU A  82
 None
 1.04A 5ecnA-2gf9A:
undetectable		 5ecnA-2gf9A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 ALA A 189
THR A 161
VAL A  45
GLU A  37
 None
 1.20A 5ecnA-2isqA:
undetectable		 5ecnA-2isqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o79 LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 THR A  26
TYR A  18
GLU A  11
HIS A  31
 None
None
None
GOL  A 502 (-4.0A)
 1.21A 5ecnA-2o79A:
undetectable		 5ecnA-2o79A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 ALA A  68
THR A  69
VAL A  55
HIS A  66
 None
 1.23A 5ecnA-2ocpA:
undetectable		 5ecnA-2ocpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE

(Pectobacterium
atrosepticum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ALA A 320
THR A 321
VAL A 121
HIS A 316
 None
 1.18A 5ecnA-2p2sA:
undetectable		 5ecnA-2p2sA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2

(Homo sapiens) 		PF00293
(NUDIX) 		4 ALA A  53
TYR A 151
VAL A  24
HIS A  88
 MN  A 229 ( 4.6A)
None
None
MN  A 229 ( 3.2A)
 1.13A 5ecnA-2pnyA:
undetectable		 5ecnA-2pnyA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb0 TELSAM DOMAIN -
LYSOZYME CHIMERA

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF02198
(SAM_PNT) 		4 THR B 119
TYR B 111
GLU B 104
HIS B 124
 None
None
MN  B 256 (-2.8A)
None
 1.06A 5ecnA-2qb0B:
undetectable		 5ecnA-2qb0B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		4 ALA A 272
TYR A 265
VAL A  37
GLU A  38
 None
 1.11A 5ecnA-2r26A:
undetectable		 5ecnA-2r26A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ALA A 282
THR A 281
VAL A 268
GLU A 266
 None
 1.20A 5ecnA-2yv3A:
undetectable		 5ecnA-2yv3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alr NANOS PROTEIN

(Danio rerio) 		PF05741
(zf-nanos) 		4 ALA A 132
THR A 133
VAL A 117
HIS A 138
 ZN  A 602 ( 4.7A)
None
None
ZN  A 602 (-3.3A)
 1.17A 5ecnA-3alrA:
undetectable		 5ecnA-3alrA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A  92
LYS A  33
GLU A  32
HIS A  78
 None
FAD  A 446 (-3.7A)
FAD  A 446 (-2.8A)
None
 1.15A 5ecnA-3cgdA:
undetectable		 5ecnA-3cgdA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqy TOLUENE
1,2-DIOXYGENASE
SYSTEM FERREDOXIN
SUBUNIT

(Pseudomonas
putida) 		PF00355
(Rieske) 		4 THR A  43
VAL A  75
LYS A  82
HIS A  44
 None
None
None
FES  A 107 (-3.2A)
 1.24A 5ecnA-3dqyA:
undetectable		 5ecnA-3dqyA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehc SNOAL-LIKE
POLYKETIDE CYCLASE

(Agrobacterium
fabrum) 		PF07366
(SnoaL) 		4 ALA A  61
TYR A   8
VAL A 101
GLU A  99
 None
 1.23A 5ecnA-3ehcA:
undetectable		 5ecnA-3ehcA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 ALA A 805
THR A 804
VAL A 856
LYS A 800
 None
 1.16A 5ecnA-3ihyA:
undetectable		 5ecnA-3ihyA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb0 PUTATIVE
UNCHARACTERIZED
PROTEIN AT2G26040

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		4 ALA A  93
VAL A 114
GLU A 118
HIS A 119
 A8S  A 189 (-3.7A)
None
None
None
 1.08A 5ecnA-3kb0A:
undetectable		 5ecnA-3kb0A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR

(Homo sapiens) 		PF13621
(Cupin_8) 		4 ALA A 317
TYR A 200
VAL A 232
GLU A 323
 None
 1.10A 5ecnA-3kcxA:
undetectable		 5ecnA-3kcxA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kij PROBABLE GLUTATHIONE
PEROXIDASE 8

(Homo sapiens) 		PF00255
(GSHPx) 		4 ALA A 105
TYR A  86
VAL A 122
GLU A 115
 None
 1.05A 5ecnA-3kijA:
undetectable		 5ecnA-3kijA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcq THIAMINE-MONOPHOSPHA
TE KINASE

(Methylobacillus
flagellatus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ALA A 166
TYR A 171
VAL A 239
GLU A 177
 None
 1.03A 5ecnA-3mcqA:
undetectable		 5ecnA-3mcqA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 331
THR A 133
VAL A 138
LYS A 368
 None
 1.07A 5ecnA-3nzgA:
0.6		 5ecnA-3nzgA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shr CGMP-DEPENDENT
PROTEIN KINASE 1

(Bos taurus) 		PF00027
(cNMP_binding) 		4 ALA A 233
LYS A 207
GLU A 210
HIS A 208
 None
 0.99A 5ecnA-3shrA:
undetectable		 5ecnA-3shrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		4 ALA A 315
THR A 314
VAL A  78
HIS A 311
 None
 0.99A 5ecnA-3ujhA:
undetectable		 5ecnA-3ujhA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		4 ALA A 286
THR A 284
VAL A 254
LYS A 259
 None
 1.22A 5ecnA-3ujpA:
undetectable		 5ecnA-3ujpA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 ALA A 986
THR A 989
GLU A1005
HIS A1006
 None
 1.23A 5ecnA-3ummA:
undetectable		 5ecnA-3ummA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnw CYTOCHROME C-552

(Thermus
thermophilus) 		PF00034
(Cytochrom_C) 		4 ALA A  90
THR A  89
VAL A  33
HIS A  86
 None
 0.99A 5ecnA-3vnwA:
undetectable		 5ecnA-3vnwA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		4 ALA A 401
THR A 400
TYR A 187
HIS A 273
 None
NA  A 501 ( 4.2A)
NA  A 501 (-4.6A)
None
 1.21A 5ecnA-3vs8A:
undetectable		 5ecnA-3vs8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj1 H3 AFFITIN

(synthetic
construct) 		PF02294
(7kD_DNA_binding) 		4 ALA B  54
VAL B   2
LYS B  56
GLU B  57
 None
 1.08A 5ecnA-4cj1B:
undetectable		 5ecnA-4cj1B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA

(Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1026
TYR A1018
GLU A1011
HIS A1031
 None
 0.99A 5ecnA-4dklA:
undetectable		 5ecnA-4dklA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		4 THR A  18
TYR A 204
GLU A  14
HIS A  13
 None
 1.21A 5ecnA-4dr0A:
undetectable		 5ecnA-4dr0A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		4 ALA A 394
THR A 391
VAL A 375
LYS A 468
 None
 1.11A 5ecnA-4dwqA:
undetectable		 5ecnA-4dwqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyv SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF00106
(adh_short) 		4 ALA A  95
THR A  94
VAL A 148
GLU A 144
 None
 1.21A 5ecnA-4dyvA:
undetectable		 5ecnA-4dyvA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		4 ALA A 312
THR A 311
VAL A 350
HIS A 154
 None
 0.96A 5ecnA-4e7wA:
undetectable		 5ecnA-4e7wA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej4 DELTA-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA

(Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1026
TYR A1018
GLU A1011
HIS A1031
 None
 1.11A 5ecnA-4ej4A:
undetectable		 5ecnA-4ej4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffj RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA

(Streptococcus
pneumoniae) 		PF00926
(DHBP_synthase) 		4 ALA A 145
THR A 146
VAL A  19
HIS A 142
 None
None
None
SO4  A 301 (-4.2A)
 1.19A 5ecnA-4ffjA:
undetectable		 5ecnA-4ffjA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 ALA A 146
TYR A 199
VAL A  25
HIS A 148
 None
 1.06A 5ecnA-4gpgA:
undetectable		 5ecnA-4gpgA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1026
TYR A1018
GLU A1011
HIS A1031
 None
None
EPE  A 602 ( 4.8A)
None
 1.02A 5ecnA-4grvA:
undetectable		 5ecnA-4grvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 136
THR A 135
TYR A 318
VAL A 346
 None
GOL  A 407 (-3.6A)
None
None
 1.12A 5ecnA-4h19A:
0.0		 5ecnA-4h19A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7l LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 THR A  26
TYR A  18
GLU A  11
HIS A  31
 None
 0.99A 5ecnA-4i7lA:
undetectable		 5ecnA-4i7lA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 ALA A 196
THR A 195
VAL A 234
GLU A 236
 SO4  A 402 (-3.3A)
None
None
None
 1.18A 5ecnA-4idaA:
undetectable		 5ecnA-4idaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 ALA A 201
THR A 200
VAL A 209
HIS A 262
 None
 1.11A 5ecnA-4idmA:
undetectable		 5ecnA-4idmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 ALA A  33
THR A  58
VAL A  75
GLU A  74
 None
 1.12A 5ecnA-4inaA:
undetectable		 5ecnA-4inaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		4 ALA A 268
VAL A 277
LYS A 273
HIS A 271
 None
 1.09A 5ecnA-4inzA:
undetectable		 5ecnA-4inzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu2 CELLULOSE-BINDING
PROTEIN

(Ruminococcus
flavefaciens) 		no annotation 4 ALA B 225
TYR B 221
VAL B 236
LYS B 231
 None
 1.20A 5ecnA-4iu2B:
undetectable		 5ecnA-4iu2B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 ALA A 127
THR A 159
TYR A 161
VAL A 110
 None
 1.20A 5ecnA-4j7mA:
undetectable		 5ecnA-4j7mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A 891
TYR A 883
GLU A 876
HIS A 896
 None
 1.08A 5ecnA-4ldeA:
undetectable		 5ecnA-4ldeA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6w FANCONI ANEMIA GROUP
M PROTEIN

(Homo sapiens) 		PF02732
(ERCC4) 		4 ALA A1942
TYR A1855
VAL A1845
HIS A1841
 None
 1.21A 5ecnA-4m6wA:
undetectable		 5ecnA-4m6wA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ALA A 801
VAL A 643
GLU A 794
HIS A 798
 None
 1.18A 5ecnA-4nhoA:
1.5		 5ecnA-4nhoA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes) 		PF13365
(Trypsin_2) 		4 ALA A 146
TYR A 199
VAL A  25
HIS A 148
 None
 1.08A 5ecnA-4nsyA:
undetectable		 5ecnA-4nsyA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 4 ALA B  72
THR B  71
TYR B  87
GLU B  96
 None
PEG  B 601 ( 4.6A)
None
None
 1.15A 5ecnA-4p37B:
undetectable		 5ecnA-4p37B:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p81 ANCESTRAL PYRR
PROTEIN (ORANGE)

(synthetic
construct) 		PF00156
(Pribosyltran) 		4 ALA A  22
TYR A 149
GLU A  27
HIS A  23
 None
 1.10A 5ecnA-4p81A:
1.6		 5ecnA-4p81A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		4 ALA A 201
THR A 203
VAL A 296
HIS A 293
 None
 1.21A 5ecnA-4r0cA:
undetectable		 5ecnA-4r0cA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA

(Macaca mulatta;
Escherichia
virus T4) 		PF00643
(zf-B_box)
PF00959
(Phage_lysozyme) 		4 THR A 329
TYR A 321
GLU A 314
HIS A 334
 None
 1.14A 5ecnA-4tn3A:
undetectable		 5ecnA-4tn3A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 4 ALA A  72
THR A  71
TYR A  87
GLU A  96
 None
 1.20A 5ecnA-4wseA:
undetectable		 5ecnA-4wseA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA

(Homo sapiens;
Escherichia
virus T4) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		4 THR A1025
TYR A1017
GLU A1010
HIS A1030
 None
 1.08A 5ecnA-4wtvA:
undetectable		 5ecnA-4wtvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1026
TYR A1018
GLU A1011
HIS A1031
 None
None
EPE  A1203 ( 4.3A)
None
 1.06A 5ecnA-4xeeA:
undetectable		 5ecnA-4xeeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yf1 LMO0812 PROTEIN

(Listeria
monocytogenes) 		PF13328
(HD_4) 		4 ALA A  93
TYR A 146
GLU A  82
HIS A  94
 None
 1.17A 5ecnA-4yf1A:
undetectable		 5ecnA-4yf1A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme) 		4 THR A  47
TYR A  39
GLU A  32
HIS A  52
 None
 1.05A 5ecnA-4yxcA:
undetectable		 5ecnA-4yxcA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN

(Toxoplasma
gondii) 		PF02430
(AMA-1)
PF07974
(EGF_2) 		4 ALA A 537
THR A 538
VAL A 542
LYS A 540
 None
 1.24A 5ecnA-4z81A:
undetectable		 5ecnA-4z81A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		4 ALA B  70
THR B  73
VAL B  86
HIS B 100
 None
 1.11A 5ecnA-5b47B:
1.1		 5ecnA-5b47B:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Medicago
truncatula) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 ALA A 131
THR A 132
LYS A  20
GLU A  23
 None
 1.17A 5ecnA-5bshA:
3.0		 5ecnA-5bshA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL

(Homo sapiens;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 THR A  26
TYR A  18
GLU A  11
HIS A  31
 None
 1.02A 5ecnA-5bz6A:
undetectable		 5ecnA-5bz6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5de0 DEFERROCHELATASE

(Vibrio cholerae) 		PF04261
(Dyp_perox) 		4 ALA A   7
THR A   6
VAL A  41
HIS A 100
 None
 1.16A 5ecnA-5de0A:
undetectable		 5ecnA-5de0A:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		6 ALA A 165
THR A 166
TYR A 170
VAL A 222
LYS A 530
GLU A 533
 LEU  A 602 (-3.1A)
LEU  A 602 ( 3.0A)
LEU  A 602 (-4.4A)
JAA  A 601 (-4.1A)
None
MG  A 603 (-3.9A)
 0.76A 5ecnA-5ecoA:
61.4		 5ecnA-5ecoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 THR A 166
TYR A 170
VAL A 222
GLU A 533
HIS A 534
 LEU  A 602 ( 3.0A)
LEU  A 602 (-4.4A)
JAA  A 601 (-4.1A)
MG  A 603 (-3.9A)
LEU  A 602 (-4.9A)
 1.16A 5ecnA-5ecoA:
61.4		 5ecnA-5ecoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		4 THR A1024
TYR A1016
GLU A1009
HIS A1029
 None
 1.01A 5ecnA-5ee7A:
undetectable		 5ecnA-5ee7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens;
Escherichia
virus T4) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		4 THR A1028
TYR A1020
GLU A1013
HIS A1033
 None
 0.93A 5ecnA-5eutA:
undetectable		 5ecnA-5eutA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kz5 IRON-SULFUR CLUSTER
ASSEMBLY ENZYME
ISCU, MITOCHONDRIAL

(Homo sapiens) 		PF01491
(Frataxin_Cyay) 		4 ALA a 126
THR a 123
LYS a 121
GLU a 143
 None
 1.21A 5ecnA-5kz5a:
undetectable		 5ecnA-5kz5a:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		4 ALA J  79
THR J  78
TYR J 116
GLU J 111
 None
 1.18A 5ecnA-5m32J:
undetectable		 5ecnA-5m32J:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562) 		4 THR A1026
TYR A1018
GLU A1011
HIS A1031
 None
 1.03A 5ecnA-5ndzA:
undetectable		 5ecnA-5ndzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9e PUTATIVE U3 SMALL
NUCLEOLAR
RIBONUCLEOPROTEIN

(Chaetomium
thermophilum) 		PF04427
(Brix) 		4 ALA A 151
THR A 150
GLU A 144
HIS A 143
 None
 1.06A 5ecnA-5o9eA:
undetectable		 5ecnA-5o9eA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 ALA A 538
THR A 537
VAL A 558
HIS A 530
 None
 1.21A 5ecnA-5oasA:
undetectable		 5ecnA-5oasA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohx CYSTATHIONINE
BETA-SYNTHASE

(Apis mellifera) 		no annotation 4 ALA A  42
THR A  41
TYR A  83
VAL A 119
 None
 1.20A 5ecnA-5ohxA:
undetectable		 5ecnA-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 ALA A 413
THR A 412
TYR A 288
GLU A 669
 None
 1.19A 5ecnA-5te1A:
undetectable		 5ecnA-5te1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA H 113
THR H 112
VAL H  18
GLU H  10
 None
 0.96A 5ecnA-5uy3H:
undetectable		 5ecnA-5uy3H:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo sapiens) 		no annotation 4 ALA A1564
THR A1565
TYR A1567
VAL A1678
 None
 1.11A 5ecnA-5wchA:
undetectable		 5ecnA-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1

(Homo sapiens) 		no annotation 4 ALA A 283
THR A 282
VAL A 275
GLU A 311
 None
 1.22A 5ecnA-5whrA:
undetectable		 5ecnA-5whrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 ALA A 376
VAL A 369
GLU A 341
HIS A 338
 None
 1.21A 5ecnA-5wi5A:
undetectable		 5ecnA-5wi5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1z DREBRIN
PROTEIN KINASE
C-BINDING PROTEIN 1

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ALA A   2
LYS C 243
GLU C 246
HIS C 247
 None
 1.01A 5ecnA-5y1zA:
undetectable		 5ecnA-5y1zA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN

(Saccharomyces
cerevisiae;
Escherichia
virus T4) 		no annotation 4 THR A  26
TYR A  18
GLU A  11
HIS A  31
 None
 1.16A 5ecnA-5yqrA:
undetectable		 5ecnA-5yqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 ALA A 465
THR A 466
VAL A 436
LYS A 430
 None
 1.18A 5ecnA-6b6lA:
undetectable		 5ecnA-6b6lA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila) 		no annotation 4 ALA A  44
THR A  42
GLU A  33
HIS A  49
 None
 1.15A 5ecnA-6b7pA:
undetectable		 5ecnA-6b7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blk SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE/PHOSPHATASE
MPRB

(Mycolicibacterium
hassiacum) 		no annotation 4 ALA C 466
THR C 465
VAL C 372
HIS C 468
 None
ATP  C 501 (-3.9A)
None
None
 1.15A 5ecnA-6blkC:
undetectable		 5ecnA-6blkC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8s LOGANIC ACID
O-METHYLTRANSFERASE

(Catharanthus
roseus) 		no annotation 4 ALA A  87
THR A  84
VAL A 110
HIS A 156
 None
 1.16A 5ecnA-6c8sA:
undetectable		 5ecnA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cty DIHYDROOROTASE

(Yersinia pestis) 		no annotation 4 ALA A 256
LYS A 260
GLU A 261
HIS A 258
 None
CSX  A 266 ( 2.7A)
None
None
 1.21A 5ecnA-6ctyA:
0.0		 5ecnA-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA H  95
TYR H  27
VAL H  78
HIS H  35
 None
 0.86A 5ecnA-6db7H:
1.0		 5ecnA-6db7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Sus scrofa) 		no annotation 4 ALA E 114
THR E 111
VAL E 106
LYS E  81
 None
 1.09A 5ecnA-6exvE:
undetectable		 5ecnA-6exvE:
undetectable