SIMILAR PATTERNS OF AMINO ACIDS FOR 5ECM_D_LEUD602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4k ANTIBODY FAB

(Mus musculus) 		no annotation 4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.76A 5ecmD-1a4kH:
0.0		 5ecmD-1a4kH:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fj1 HYBRIDOMA ANTIBODY
LA2 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 109
GLU B  89
 None
 0.61A 5ecmD-1fj1B:
0.0		 5ecmD-1fj1B:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcv IMMUNOGLOBULIN G

(Lama glama) 		PF07686
(V-set) 		4 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.75A 5ecmD-1hcvA:
0.0		 5ecmD-1hcvA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i3u ANTIBODY VHH LAMA
DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 ALA A  97
THR A  96
VAL A 125
GLU A  94
 None
 0.75A 5ecmD-1i3uA:
0.0		 5ecmD-1i3uA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 ALA B 392
THR B 391
VAL B 416
GLU B 389
 None
 0.74A 5ecmD-1i8kB:
undetectable		 5ecmD-1i8kB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  91
THR H  90
VAL H 114
GLU H  88
 None
 0.73A 5ecmD-1i9iH:
0.0		 5ecmD-1i9iH:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikf IGG1-KAPPA R45-45-11
FAB (HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 122
GLU H  89
 None
 0.73A 5ecmD-1ikfH:
0.0		 5ecmD-1ikfH:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfa MONOCLONAL ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 117
GLU H  89
 None
 0.72A 5ecmD-1kfaH:
0.0		 5ecmD-1kfaH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo4 IG GAMMA 2A HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  91
THR H  90
VAL H 114
GLU H  88
 None
 0.71A 5ecmD-1lo4H:
0.0		 5ecmD-1lo4H:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvf IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 122
GLU A  89
 None
 0.76A 5ecmD-1mvfA:
undetectable		 5ecmD-1mvfA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op9 HL6 CAMEL VHH
FRAGMENT

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA A  89
THR A  88
VAL A 117
GLU A  86
 None
 0.73A 5ecmD-1op9A:
undetectable		 5ecmD-1op9A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle HEAVY CHAIN ANTIBODY
FV FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 114
GLU H  89
 None
 0.71A 5ecmD-1qleH:
undetectable		 5ecmD-1qleH:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t04 HUZAF ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 113
GLU B  89
 None
 0.75A 5ecmD-1t04B:
undetectable		 5ecmD-1t04B:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 ALA A 223
VAL A 226
TYR A 150
VAL A 214
HIS A 220
 None
None
None
None
ZN  A 401 (-3.3A)
 1.42A 5ecmD-1xx4A:
0.3		 5ecmD-1xx4A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		4 ALA A 208
THR A 209
VAL A 212
VAL A 219
 None
 0.76A 5ecmD-1yloA:
undetectable		 5ecmD-1yloA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zea MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.75A 5ecmD-1zeaH:
undetectable		 5ecmD-1zeaH:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.53A 5ecmD-2ejvA:
1.2		 5ecmD-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4a ANTIBODY CAB-RN05

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 117
GLU B  89
 None
 0.73A 5ecmD-2p4aB:
undetectable		 5ecmD-2p4aB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x89 ANTIBODY

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 124
GLU A  89
 None
 0.73A 5ecmD-2x89A:
undetectable		 5ecmD-2x89A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05

(Homo sapiens) 		PF07686
(V-set) 		4 ALA D  92
THR D  91
VAL D 127
GLU D  89
 None
 0.74A 5ecmD-2xtjD:
undetectable		 5ecmD-2xtjD:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezj NANOBODY NBGSPD_7

(Lama glama) 		PF07686
(V-set) 		4 ALA B  91
THR B  90
VAL B 116
GLU B  88
 None
 0.74A 5ecmD-3ezjB:
undetectable		 5ecmD-3ezjB:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzu IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA H  94
THR H  93
VAL H 114
GLU H  91
 None
 0.71A 5ecmD-3fzuH:
undetectable		 5ecmD-3fzuH:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG4930

(Drosophila
melanogaster) 		PF08785
(Ku_PK_bind) 		4 ALA C  63
THR C  62
TYR C  25
VAL C  44
 None
 0.76A 5ecmD-3ismC:
1.7		 5ecmD-3ismC:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7u ANTIBODY

(Lama glama) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 118
GLU A  89
 None
 0.75A 5ecmD-3k7uA:
undetectable		 5ecmD-3k7uA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k80 ANTIBODY

(Lama glama) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 120
GLU A  89
 None
 0.76A 5ecmD-3k80A:
undetectable		 5ecmD-3k80A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3liz 4C3 MONOCLONAL
ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 115
GLU H  89
 None
 0.75A 5ecmD-3lizH:
undetectable		 5ecmD-3lizH:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
EPSILON

(Bos taurus) 		PF04733
(Coatomer_E) 		4 ALA A 185
THR A 186
VAL A 189
GLU A 177
 None
 0.59A 5ecmD-3mkrA:
undetectable		 5ecmD-3mkrA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0m LLAMA VHH A12

(Lama glama) 		PF07686
(V-set) 		4 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.74A 5ecmD-3r0mA:
undetectable		 5ecmD-3r0mA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb SINGLE DOMAIN
ANTIBODY VHH

(Lama glama) 		PF07686
(V-set) 		4 ALA A  93
THR A  92
VAL A 124
GLU A  90
 None
 0.70A 5ecmD-3stbA:
undetectable		 5ecmD-3stbA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5e PS2-8

(Lama glama) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 123
GLU A  89
 None
 0.75A 5ecmD-4b5eA:
undetectable		 5ecmD-4b5eA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9q ANTI-FACTOR D, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA E  92
THR E  91
VAL E 117
GLU E  89
 None
 0.76A 5ecmD-4d9qE:
undetectable		 5ecmD-4d9qE:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dka SINGLE DOMAIN
ANTIBODY VHH

(Lama glama) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 123
GLU A  89
 None
 0.75A 5ecmD-4dkaA:
undetectable		 5ecmD-4dkaA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 ALA A 507
THR A 508
VAL A 511
GLU A 501
 None
 0.71A 5ecmD-4f7zA:
1.0		 5ecmD-4f7zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgo PERIPLASMIC PROTEIN

(Legionella
pneumophila) 		PF06035
(Peptidase_C93) 		5 ALA A 163
VAL A 207
TYR A 208
GLU A 138
HIS A 172
 None
None
None
CA  A 301 (-4.2A)
None
 0.97A 5ecmD-4fgoA:
0.5		 5ecmD-4fgoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhb NB179

(Lama glama) 		PF07686
(V-set) 		4 ALA D  92
THR D  91
VAL D 125
GLU D  89
 None
 0.76A 5ecmD-4fhbD:
undetectable		 5ecmD-4fhbD:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.56A 5ecmD-4g1pA:
undetectable		 5ecmD-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grw NANOBODY 37D5

(Lama glama) 		PF07686
(V-set) 		4 ALA F  92
THR F  91
VAL F 122
GLU F  89
 None
 0.74A 5ecmD-4grwF:
undetectable		 5ecmD-4grwF:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ALA C 750
THR C 751
VAL C 756
VAL C 803
 None
 0.71A 5ecmD-4hb4C:
1.9		 5ecmD-4hb4C:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
HEAVY CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 111
GLU H  85
 None
 0.71A 5ecmD-4hbcH:
undetectable		 5ecmD-4hbcH:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hii FAB 023.102 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  88
THR B  87
VAL B 109
GLU B  85
 None
 0.68A 5ecmD-4hiiB:
undetectable		 5ecmD-4hiiB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 ALA A 773
THR A 774
VAL A 777
TYR A 778
 None
 0.59A 5ecmD-4jzaA:
1.3		 5ecmD-4jzaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 ALA A 493
THR A 494
VAL A 499
TYR A 500
 None
 0.68A 5ecmD-4kf7A:
undetectable		 5ecmD-4kf7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krm NANOBODY/VHH DOMAIN
7D12

(Lama glama) 		PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 120
GLU B  89
 None
 0.72A 5ecmD-4krmB:
undetectable		 5ecmD-4krmB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksd R2 PROTEIN

(Lama glama) 		PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 114
GLU B  89
 None
 0.75A 5ecmD-4ksdB:
undetectable		 5ecmD-4ksdB:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvn HUMAN IGG HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 121
GLU H  89
 None
 0.74A 5ecmD-4kvnH:
undetectable		 5ecmD-4kvnH:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxz GC1008 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 116
GLU H  89
 None
 0.76A 5ecmD-4kxzH:
undetectable		 5ecmD-4kxzH:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgr CAMELID NANOBODY
(VHH3)

(Vicugna pacos) 		PF07686
(V-set) 		4 ALA B  91
THR B  90
VAL B 115
GLU B  88
 None
 0.72A 5ecmD-4lgrB:
undetectable		 5ecmD-4lgrB:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lly MUTATED PERTUZUMAB
FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 115
GLU A  89
 None
 0.75A 5ecmD-4llyA:
undetectable		 5ecmD-4llyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxv ANTI-LYMPHOTOXIN
ALPHA ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA F  88
THR F  87
VAL F 109
GLU F  85
 None
 0.75A 5ecmD-4mxvF:
undetectable		 5ecmD-4mxvF:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc2 B39 VHH

(Lama glama) 		PF07686
(V-set) 		4 ALA B  91
THR B  90
VAL B 118
GLU B  88
 None
 0.75A 5ecmD-4nc2B:
undetectable		 5ecmD-4nc2B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuj PGT152 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  88
THR B  87
VAL B 109
GLU B  85
 None
 0.74A 5ecmD-4nujB:
undetectable		 5ecmD-4nujB:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ocr CAP256-VRC26.01
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.74A 5ecmD-4ocrH:
undetectable		 5ecmD-4ocrH:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onf 3D6 FAB ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 115
GLU H  89
 None
 0.74A 5ecmD-4onfH:
undetectable		 5ecmD-4onfH:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p49 ANTIBODY SCFV B8

(Gallus gallus) 		PF07686
(V-set) 		4 ALA A 213
THR A 212
VAL A 240
GLU A 210
 None
 0.76A 5ecmD-4p49A:
undetectable		 5ecmD-4p49A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6i HEAVY CHAIN OF
MURINE 2D5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  88
THR B  87
VAL B 109
GLU B  85
 None
 0.75A 5ecmD-4q6iB:
undetectable		 5ecmD-4q6iB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlr LLAMA NANOBODY N02
VH DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 120
GLU A  89
 None
 0.73A 5ecmD-4qlrA:
undetectable		 5ecmD-4qlrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uta BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 118
GLU H  89
 None
 0.76A 5ecmD-4utaH:
undetectable		 5ecmD-4utaH:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6) 		4 VAL A 455
TYR A 472
GLU A 447
HIS A 448
 None
 0.66A 5ecmD-4uzyA:
1.4		 5ecmD-4uzyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w68 SINGLE DOMAIN
ANTIBODY

(Lama glama) 		no annotation 4 ALA B  95
THR B  94
VAL B 125
GLU B  92
 None
 0.76A 5ecmD-4w68B:
undetectable		 5ecmD-4w68B:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6y NANOBODY NBFEDF9

(Lama glama) 		PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 125
GLU B  89
 None
 0.75A 5ecmD-4w6yB:
undetectable		 5ecmD-4w6yB:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wen ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION

(Lama glama) 		PF07686
(V-set) 		4 ALA B 891
THR B 890
VAL B 917
GLU B 888
 None
 0.75A 5ecmD-4wenB:
undetectable		 5ecmD-4wenB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xml HEAVY CHAIN OF HIV-1
GP120 V3-SPECIFIC
HUMAN MONOCLONAL
ANTIBODY 2424

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.72A 5ecmD-4xmlH:
undetectable		 5ecmD-4xmlH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.76A 5ecmD-4ydkH:
undetectable		 5ecmD-4ydkH:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhp FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 117
GLU A  89
 None
 0.75A 5ecmD-4yhpA:
undetectable		 5ecmD-4yhpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boz VHH SINGLE CHAIN
ANTIBODY E1

(Vicugna pacos) 		PF07686
(V-set) 		4 ALA G  92
THR G  91
VAL G 122
GLU G  89
 None
 0.76A 5ecmD-5bozG:
undetectable		 5ecmD-5bozG:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq7 FAB 5F-10-HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 114
GLU A  89
 None
 0.73A 5ecmD-5bq7A:
undetectable		 5ecmD-5bq7A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0n FAB CA33 HEAVY CHAIN

(Oryctolagus
cuniculus) 		no annotation 4 ALA H  88
THR H  87
VAL H 116
GLU H  85
 None
 0.76A 5ecmD-5c0nH:
undetectable		 5ecmD-5c0nH:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhx ANTI-REV ANTIBODY
FAB SINGLE-CHAIN
VARIABLE FRAGMENT,
LIGHT CHAIN,ANTI-REV
ANTIBODY FAB
SINGLE-CHAIN
VARIABLE FRAGMENT,
HEAVY CHAIN

(Oryctolagus
cuniculus) 		PF07686
(V-set) 		4 ALA B 200
THR B 199
VAL B 223
GLU B 197
 None
 0.73A 5ecmD-5dhxB:
undetectable		 5ecmD-5dhxB:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dr5 ABD09097 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 111
GLU H  89
 None
 0.72A 5ecmD-5dr5H:
undetectable		 5ecmD-5dr5H:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		7 ALA A 165
THR A 166
VAL A 169
TYR A 170
VAL A 222
GLU A 533
HIS A 534
 LEU  A 602 (-3.1A)
LEU  A 602 ( 3.0A)
LEU  A 602 (-4.6A)
LEU  A 602 (-4.4A)
JAA  A 601 (-4.1A)
MG  A 603 (-3.9A)
LEU  A 602 (-4.9A)
 0.63A 5ecmD-5ecoA:
61.1		 5ecmD-5ecoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA E  92
THR E  91
VAL E 123
GLU E  89
 None
 0.75A 5ecmD-5fgcE:
undetectable		 5ecmD-5fgcE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grv HOMO-SPECIFIC
DIABODY HEAVY CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ALA L  91
THR L  90
VAL L 114
GLU L  88
 None
 0.72A 5ecmD-5grvL:
undetectable		 5ecmD-5grvL:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs3 DIABODY PROTEIN

(Homo sapiens) 		no annotation 4 ALA H  92
THR H  91
VAL H 115
GLU H  89
 None
 0.75A 5ecmD-5gs3H:
undetectable		 5ecmD-5gs3H:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifh HEAVY CHAIN OF THE
FAB FRAGMENT FROM
BCR DERIVED FROM THE
P11475 CLL CLONE

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
THR H  91
VAL H 112
GLU H  89
 None
 0.73A 5ecmD-5ifhH:
undetectable		 5ecmD-5ifhH:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihl 3H56-5 DOMAIN
ANTIBODY (DAB)

(Homo sapiens) 		PF07686
(V-set) 		4 ALA B  88
THR B  87
VAL B 109
GLU B  85
 ALA  B  88 ( 0.0A)
THR  B  87 ( 0.8A)
VAL  B 109 ( 0.5A)
GLU  B  85 ( 0.6A)
 0.75A 5ecmD-5ihlB:
undetectable		 5ecmD-5ihlB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja8 NANOBODY 2

(Lama glama) 		PF07686
(V-set) 		4 ALA B  93
THR B  92
VAL B 118
GLU B  90
 None
 0.76A 5ecmD-5ja8B:
undetectable		 5ecmD-5ja8B:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqh NANOBODY60, NB60

(Lama glama) 		no annotation 4 ALA D  91
THR D  90
VAL D 115
GLU D  88
 None
 0.75A 5ecmD-5jqhD:
undetectable		 5ecmD-5jqhD:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  92
THR A  91
VAL A 114
GLU A  89
 None
 0.74A 5ecmD-5kn5A:
undetectable		 5ecmD-5kn5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbs BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8

(Homo sapiens) 		PF07686
(V-set) 		4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.71A 5ecmD-5lbsH:
undetectable		 5ecmD-5lbsH:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzv NANOBODY 22E11

(Lama glama) 		no annotation 4 ALA D  92
THR D  91
VAL D 119
GLU D  89
 None
 0.74A 5ecmD-5mzvD:
undetectable		 5ecmD-5mzvD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o02 NANOBODY (VHH)
NANO-4

(Vicugna pacos) 		PF07686
(V-set) 		4 ALA C  92
THR C  91
VAL C 120
GLU C  89
 None
 0.73A 5ecmD-5o02C:
undetectable		 5ecmD-5o02C:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocl ANTI-VGLUT NANOBODY

(Lama glama) 		PF07686
(V-set) 		4 ALA B  94
THR B  93
VAL B 122
GLU B  91
 None
 0.73A 5ecmD-5oclB:
undetectable		 5ecmD-5oclB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		5 ALA A 413
THR A 412
VAL A 415
GLU A 669
HIS A 410
 None
 1.43A 5ecmD-5te1A:
undetectable		 5ecmD-5te1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		5 ALA A 413
THR A 412
VAL A 415
TYR A 288
HIS A 410
 None
 1.47A 5ecmD-5te1A:
undetectable		 5ecmD-5te1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjw NP-SPECIFIC
INHIBITORY VHH

(Vicugna pacos) 		PF07686
(V-set) 		4 ALA K  93
THR K  92
VAL K 120
GLU K  90
 None
 0.73A 5ecmD-5tjwK:
undetectable		 5ecmD-5tjwK:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp3 F-VHH-4

(Lama glama) 		PF07686
(V-set) 		4 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.76A 5ecmD-5tp3A:
undetectable		 5ecmD-5tp3A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 232
THR A 231
VAL A 106
VAL A  41
HIS A 233
 None
 1.19A 5ecmD-5uxnA:
undetectable		 5ecmD-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl2 T4 NANOBODY

(Lama glama) 		no annotation 4 ALA A  94
THR A  93
VAL A 122
GLU A  91
 None
 0.70A 5ecmD-5vl2A:
undetectable		 5ecmD-5vl2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnw NB.B201

(synthetic
construct) 		no annotation 4 ALA C  91
THR C  90
VAL C 114
GLU C  88
 None
 0.75A 5ecmD-5vnwC:
undetectable		 5ecmD-5vnwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3

(Vicugna pacos) 		no annotation 4 ALA B  92
THR B  91
VAL B 115
GLU B  89
 None
 0.73A 5ecmD-5vxjB:
undetectable		 5ecmD-5vxjB:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxm SINGLE-DOMAIN
ANTIBODY 20IPAD

(Vicugna pacos) 		no annotation 4 ALA B  92
THR B  91
VAL B 121
GLU B  89
 None
 0.74A 5ecmD-5vxmB:
undetectable		 5ecmD-5vxmB:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcc VRC 315 02-1F07 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.58A 5ecmD-5wccH:
undetectable		 5ecmD-5wccH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.71A 5ecmD-5xcuA:
undetectable		 5ecmD-5xcuA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjm FABH

(Mus musculus) 		no annotation 4 ALA H  92
THR H  91
VAL H 116
GLU H  89
 None
 0.76A 5ecmD-5xjmH:
undetectable		 5ecmD-5xjmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9f HEAVY CHAIN OF FAB
FRAGMENT OF ANTIBODY
28F10

(Mus musculus) 		no annotation 4 ALA L  92
THR L  91
VAL L 119
GLU L  89
 None
 0.74A 5ecmD-5y9fL:
undetectable		 5ecmD-5y9fL:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yoy GOLIMUMAB HEAVY
CHAIN VARIABLE
REGION

(Homo sapiens) 		no annotation 4 ALA G  92
THR G  91
VAL G 122
GLU G  89
 None
 0.72A 5ecmD-5yoyG:
undetectable		 5ecmD-5yoyG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apo ANTI-MARBURGVIRUS
NUCLEOPROTEIN SINGLE
DOMAIN ANTIBODY A

(Lama glama) 		no annotation 4 ALA A  92
THR A  91
VAL A 114
GLU A  89
 None
 0.73A 5ecmD-6apoA:
undetectable		 5ecmD-6apoA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fxn BELIMUMAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 ALA D  92
THR D  91
VAL D 119
GLU D  89
 None
 0.74A 5ecmD-6fxnD:
undetectable		 5ecmD-6fxnD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama) 		no annotation 4 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.72A 5ecmD-6gzpA:
undetectable		 5ecmD-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  92
THR B  91
VAL B 117
GLU B  89
 None
 0.73A 5ecmD-8fabB:
undetectable		 5ecmD-8fabB:
17.45