SIMILAR PATTERNS OF AMINO ACIDS FOR 5ECM_A_LEUA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ALA C 405
THR C 408
TYR C 407
HIS C  78
 None
 1.13A 5ecmA-1a5lC:
undetectable		 5ecmA-1a5lC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a80 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE A

(Corynebacterium
sp.) 		PF00248
(Aldo_ket_red) 		4 THR A  46
ALA A  47
THR A  74
TYR A 105
 None
 1.02A 5ecmA-1a80A:
0.5		 5ecmA-1a80A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 THR A 211
ALA A 212
THR A 149
TYR A  22
 None
 1.28A 5ecmA-1dgsA:
undetectable		 5ecmA-1dgsA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 THR A 544
ALA A 545
THR A 535
HIS A 521
 None
None
None
XYP  A1719 (-4.1A)
 1.31A 5ecmA-1gqjA:
0.4		 5ecmA-1gqjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 THR A 307
ALA A 319
THR A 320
HIS A 309
 None
 1.27A 5ecmA-1hjvA:
1.2		 5ecmA-1hjvA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huj INORGANIC
PYROPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF00719
(Pyrophosphatase) 		4 THR A 151
ALA A 112
THR A 110
HIS A 107
 None
 1.23A 5ecmA-1hujA:
undetectable		 5ecmA-1hujA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 THR A 175
ALA A 176
TYR A 243
HIS A 177
 None
 1.23A 5ecmA-1jqoA:
0.2		 5ecmA-1jqoA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus) 		PF00704
(Glyco_hydro_18) 		4 THR A 286
ALA A 298
THR A 299
HIS A 288
 None
 1.27A 5ecmA-1ljyA:
0.2		 5ecmA-1ljyA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 THR A  50
ALA A  47
THR A  49
HIS A  58
 HEM  A 803 ( 4.8A)
None
None
HEM  A 803 (-3.3A)
 1.32A 5ecmA-1m64A:
undetectable		 5ecmA-1m64A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 THR A  48
ALA A  49
THR A  76
TYR A 105
 None
 1.06A 5ecmA-1mzrA:
undetectable		 5ecmA-1mzrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onl GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Thermus
thermophilus) 		PF01597
(GCV_H) 		4 ALA A  31
THR A  28
TYR A  95
HIS A  13
 None
 1.39A 5ecmA-1onlA:
undetectable		 5ecmA-1onlA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz1 GENERAL STRESS
PROTEIN 69

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 THR A  53
ALA A  54
THR A  83
TYR A 122
 None
 1.24A 5ecmA-1pz1A:
undetectable		 5ecmA-1pz1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd0 VHH-R2 ANTI-RR6
ANTIBODY

(Lama glama) 		PF07686
(V-set) 		4 THR A  80
ALA A  23
THR A  81
TYR A  83
 None
 1.20A 5ecmA-1qd0A:
undetectable		 5ecmA-1qd0A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1

(Caenorhabditis
elegans) 		PF00248
(Aldo_ket_red) 		4 THR A  48
ALA A  49
THR A  80
TYR A 111
 None
 1.08A 5ecmA-1qwkA:
undetectable		 5ecmA-1qwkA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjc CAMELID HEAVY CHAIN
ANTIBODY

(Camelus
dromedarius) 		PF07686
(V-set) 		4 THR A  24
ALA A  23
THR A  78
TYR A  80
 None
 1.20A 5ecmA-1rjcA:
undetectable		 5ecmA-1rjcA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 THR A 610
ALA A 609
TYR A 573
HIS A 532
 None
 1.32A 5ecmA-1rw9A:
undetectable		 5ecmA-1rw9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 THR A 216
ALA A 217
THR A 154
TYR A  22
 None
 1.29A 5ecmA-1v9pA:
undetectable		 5ecmA-1v9pA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		4 THR A  48
ALA A  49
THR A  76
TYR A 107
 None
 1.08A 5ecmA-1vbjA:
undetectable		 5ecmA-1vbjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		4 ALA A 124
THR A 125
TYR A 185
HIS A 222
 None
 1.30A 5ecmA-1vh1A:
undetectable		 5ecmA-1vh1A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		4 THR A  46
ALA A  47
THR A  78
TYR A 109
 None
 1.02A 5ecmA-1vp5A:
undetectable		 5ecmA-1vp5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6f ZINC FINGER PROTEIN
462

(Homo sapiens) 		no annotation 4 THR A  42
ALA A  39
THR A  38
TYR A  26
 None
 0.88A 5ecmA-1x6fA:
undetectable		 5ecmA-1x6fA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anv LYSOZYME

(Salmonella
virus P22) 		PF00959
(Phage_lysozyme) 		4 THR A  37
THR A  31
TYR A  23
HIS A  36
 None
 1.26A 5ecmA-2anvA:
undetectable		 5ecmA-2anvA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asr ASPARTATE RECEPTOR

(Escherichia
coli) 		PF02203
(TarH) 		4 THR A  56
ALA A 100
TYR A 131
HIS A 103
 None
 1.31A 5ecmA-2asrA:
undetectable		 5ecmA-2asrA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 THR A 398
ALA A 414
TYR A 476
HIS A 415
 None
 1.27A 5ecmA-2eidA:
undetectable		 5ecmA-2eidA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 THR A  60
ALA A  61
THR A  58
TYR A  80
 None
 1.11A 5ecmA-2gz3A:
undetectable		 5ecmA-2gz3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 THR A 624
ALA A 625
THR A 626
HIS A 421
 MGD  A 811 (-2.7A)
None
MGD  A 811 (-3.2A)
None
 1.40A 5ecmA-2jirA:
undetectable		 5ecmA-2jirA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		4 THR A 190
ALA A 187
TYR A  90
HIS A 211
 None
 1.25A 5ecmA-2veoA:
undetectable		 5ecmA-2veoA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		4 THR A 359
ALA A 362
TYR A 522
HIS A 384
 None
 1.21A 5ecmA-2ww8A:
1.2		 5ecmA-2ww8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		4 THR A  54
ALA A  55
THR A  82
TYR A 113
 None
 1.05A 5ecmA-2wzmA:
undetectable		 5ecmA-2wzmA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF01135
(PCMT) 		4 THR A  95
ALA A  92
TYR A 127
HIS A  91
 None
 1.40A 5ecmA-2yxeA:
undetectable		 5ecmA-2yxeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 THR A 185
ALA A 184
THR A 183
HIS A 142
 FAD  A 600 (-3.7A)
None
FAD  A 600 (-4.1A)
FAD  A 600 (-3.5A)
 1.23A 5ecmA-2yylA:
undetectable		 5ecmA-2yylA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjm PUTATIVE
BETA-LACTAMASE

(Enterococcus
faecalis) 		PF13354
(Beta-lactamase2) 		4 THR A 106
ALA A 107
THR A 109
HIS A 266
 None
 1.30A 5ecmA-3cjmA:
undetectable		 5ecmA-3cjmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di5 DINB-LIKE PROTEIN

(Bacillus cereus) 		PF05163
(DinB) 		4 THR A  51
ALA A  52
TYR A  84
HIS A  48
 None
None
None
NI  A 168 (-3.5A)
 1.22A 5ecmA-3di5A:
undetectable		 5ecmA-3di5A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus) 		PF03372
(Exo_endo_phos) 		4 THR A 203
ALA A 204
THR A 205
HIS A 252
 CA  A 281 (-3.9A)
None
None
None
 0.96A 5ecmA-3dniA:
undetectable		 5ecmA-3dniA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		4 THR A 176
ALA A 171
THR A 174
TYR A 317
 None
GOL  A 502 (-3.5A)
None
None
 1.26A 5ecmA-3h14A:
1.7		 5ecmA-3h14A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ha2 NADPH-QUINONE
REDUCTASE

(Pediococcus
pentosaceus) 		PF02525
(Flavodoxin_2) 		4 THR A  80
ALA A  83
THR A  84
TYR A  88
 SO4  A 179 (-4.0A)
None
None
None
 1.22A 5ecmA-3ha2A:
2.2		 5ecmA-3ha2A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 THR A 269
ALA A 270
THR A 271
TYR A 244
 None
 1.26A 5ecmA-3hsyA:
undetectable		 5ecmA-3hsyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 4 THR A 283
ALA A 282
THR A 289
HIS A 281
 None
 1.30A 5ecmA-3ihmA:
undetectable		 5ecmA-3ihmA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixc HEXAPEPTIDE
TRANSFERASE FAMILY
PROTEIN

(Anaplasma
phagocytophilum) 		PF00132
(Hexapep) 		4 THR A  68
ALA A  91
THR A  75
HIS A  90
 None
None
None
MG  A 171 (-3.5A)
 1.38A 5ecmA-3ixcA:
undetectable		 5ecmA-3ixcA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 THR A  48
ALA A  45
THR A  44
TYR A 134
 None
 1.40A 5ecmA-3jq0A:
undetectable		 5ecmA-3jq0A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Yersinia pestis) 		PF02348
(CTP_transf_3) 		4 ALA A 124
THR A 125
TYR A 185
HIS A 222
 None
None
IMD  A 301 (-3.9A)
None
 1.36A 5ecmA-3jtjA:
undetectable		 5ecmA-3jtjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2p DNA LIGASE 3

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 THR A 638
ALA A 710
THR A 709
HIS A 708
 None
 1.34A 5ecmA-3l2pA:
undetectable		 5ecmA-3l2pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 THR A  51
ALA A  52
THR A  83
TYR A 114
 None
 1.07A 5ecmA-3ln3A:
undetectable		 5ecmA-3ln3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0k ALDO/KETO REDUCTASE

(Brucella
abortus) 		PF00248
(Aldo_ket_red) 		4 THR A  65
ALA A  66
THR A  93
TYR A 124
 None
 1.10A 5ecmA-3o0kA:
undetectable		 5ecmA-3o0kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oam 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Vibrio cholerae) 		PF02348
(CTP_transf_3) 		4 ALA A 124
THR A 125
TYR A 185
HIS A 222
 None
 1.29A 5ecmA-3oamA:
undetectable		 5ecmA-3oamA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		4 THR A 246
ALA A 322
THR A 323
HIS A 249
 OGA  A 454 (-3.8A)
None
OGA  A 454 (-2.9A)
NI  A   2 ( 3.3A)
 1.22A 5ecmA-3puaA:
undetectable		 5ecmA-3puaA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 THR A 174
ALA A 145
TYR A 218
HIS A 172
 None
 1.15A 5ecmA-3rcnA:
undetectable		 5ecmA-3rcnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 THR A 287
ALA A 290
TYR A 431
HIS A 291
 None
 1.14A 5ecmA-3ttsA:
undetectable		 5ecmA-3ttsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 143
ALA A 140
THR A 139
HIS A  68
 None
None
CL  A 408 ( 4.9A)
None
 1.39A 5ecmA-3u0fA:
undetectable		 5ecmA-3u0fA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 THR A  92
ALA A  95
TYR A1096
HIS A  96
 None
 1.25A 5ecmA-3ummA:
undetectable		 5ecmA-3ummA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		4 ALA A 401
THR A 400
TYR A 187
HIS A 273
 None
NA  A 501 ( 4.2A)
NA  A 501 (-4.6A)
None
 1.36A 5ecmA-3vs8A:
undetectable		 5ecmA-3vs8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 ALA A 219
THR A 218
TYR A 223
HIS A 246
 None
 1.36A 5ecmA-3vtrA:
undetectable		 5ecmA-3vtrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 THR A 248
ALA A 219
TYR A 275
HIS A 246
 None
 1.14A 5ecmA-3vtrA:
undetectable		 5ecmA-3vtrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Escherichia
coli;
Archaeoglobus
fulgidus) 		PF13416
(SBP_bac_8) 		4 THR A 838
ALA A 797
THR A 798
HIS A 841
 None
 1.12A 5ecmA-3waiA:
undetectable		 5ecmA-3waiA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 THR A 838
ALA A 797
THR A 798
HIS A 841
 None
 1.14A 5ecmA-3wajA:
undetectable		 5ecmA-3wajA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbx PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		4 THR A  54
ALA A  55
THR A  78
TYR A 109
 None
 1.05A 5ecmA-3wbxA:
undetectable		 5ecmA-3wbxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 THR A  54
ALA A  55
THR A  86
TYR A 117
 None
 1.06A 5ecmA-3wczA:
1.5		 5ecmA-3wczA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 THR A 203
ALA A 204
THR A 205
HIS A 252
 CA  A 301 (-3.7A)
None
None
PO4  A 310 (-4.1A)
 0.93A 5ecmA-4awnA:
undetectable		 5ecmA-4awnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 THR A 369
ALA A 368
TYR A 293
HIS A 343
 None
 1.23A 5ecmA-4dalA:
undetectable		 5ecmA-4dalA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eln TYPE III EFFECTOR
XOPAI

(Xanthomonas
citri) 		PF01129
(ART) 		4 THR A 109
ALA A 106
THR A 105
HIS A 175
 None
 1.18A 5ecmA-4elnA:
undetectable		 5ecmA-4elnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE

(Leishmania
major) 		PF00248
(Aldo_ket_red) 		4 THR A  50
ALA A  51
THR A  78
TYR A 109
 None
 1.04A 5ecmA-4f40A:
undetectable		 5ecmA-4f40A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
subtilis) 		PF02350
(Epimerase_2) 		4 THR A 205
ALA A 206
THR A 282
HIS A 207
 UDP  A 402 ( 4.8A)
None
None
UD1  A 401 ( 4.0A)
 1.27A 5ecmA-4fkzA:
1.9		 5ecmA-4fkzA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 THR A  52
ALA A  99
THR A 101
TYR A 124
 None
 1.28A 5ecmA-4fn7A:
undetectable		 5ecmA-4fn7A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		4 THR A  49
ALA A  50
THR A  77
TYR A 108
 None
 1.01A 5ecmA-4fziA:
undetectable		 5ecmA-4fziA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gak ACYL-ACP
THIOESTERASE

(Spirosoma
linguale) 		PF01643
(Acyl-ACP_TE) 		4 THR A  83
THR A  82
TYR A  80
HIS A  90
 None
 1.14A 5ecmA-4gakA:
undetectable		 5ecmA-4gakA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		4 THR B  21
ALA B  22
THR B  11
HIS B  20
 None
 1.24A 5ecmA-4hzuB:
undetectable		 5ecmA-4hzuB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 THR A 771
ALA A 773
THR A 774
TYR A 778
 None
 1.02A 5ecmA-4jzaA:
1.5		 5ecmA-4jzaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum) 		PF00082
(Peptidase_S8) 		4 THR A 593
ALA A 594
THR A 430
HIS A 379
 None
 1.18A 5ecmA-4lvoA:
undetectable		 5ecmA-4lvoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus) 		PF00156
(Pribosyltran) 		4 THR A 136
ALA A 133
THR A 132
TYR A  98
 None
None
AMP  A 300 (-3.6A)
None
 1.36A 5ecmA-4m0kA:
4.0		 5ecmA-4m0kA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhb PUTATIVE ALDO/KETO
REDUCTASE

(Yersinia pestis) 		PF00248
(Aldo_ket_red) 		4 THR A  59
ALA A  60
THR A  87
TYR A 118
 None
 1.05A 5ecmA-4mhbA:
undetectable		 5ecmA-4mhbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 4 THR B 504
ALA B 494
THR B 495
TYR B 450
 None
 1.36A 5ecmA-4o9dB:
undetectable		 5ecmA-4o9dB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 THR A  53
ALA A  54
THR A  81
TYR A 112
 None
 1.09A 5ecmA-4otkA:
undetectable		 5ecmA-4otkA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae) 		PF01095
(Pectinesterase) 		4 THR A  22
ALA A  24
THR A  25
TYR A 265
 None
 1.12A 5ecmA-4pmhA:
undetectable		 5ecmA-4pmhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3m MGS-M4

(unidentified) 		PF00248
(Aldo_ket_red) 		4 THR A  44
ALA A  45
THR A  72
TYR A 103
 None
 1.01A 5ecmA-4q3mA:
1.6		 5ecmA-4q3mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdq BESTROPHIN-1

(Gallus gallus) 		PF01062
(Bestrophin) 		4 THR A 348
ALA A 350
THR A 351
TYR A 354
 None
 0.97A 5ecmA-4rdqA:
undetectable		 5ecmA-4rdqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4l BETA-LACTAMASE NDM-1

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		4 THR A  91
ALA A  92
THR A  98
HIS A  61
 None
 1.35A 5ecmA-4u4lA:
undetectable		 5ecmA-4u4lA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 THR A 194
ALA A 195
THR A 192
TYR A 187
 None
 1.37A 5ecmA-4uphA:
undetectable		 5ecmA-4uphA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn9 NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 ALA A 143
THR A 144
TYR A  55
HIS A  74
 None
CLF  A 605 ( 4.6A)
CLF  A 605 (-4.9A)
None
 1.23A 5ecmA-4wn9A:
undetectable		 5ecmA-4wn9A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		4 THR A 459
ALA A 536
THR A 538
TYR A 567
 None
 1.32A 5ecmA-4x1zA:
undetectable		 5ecmA-4x1zA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xea PEPTIDASE M16 DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ALA A  42
THR A  43
TYR A 195
HIS A 100
 None
 1.14A 5ecmA-4xeaA:
undetectable		 5ecmA-4xeaA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Mycobacterium
tuberculosis) 		PF01180
(DHO_dh) 		4 THR A 147
ALA A  93
THR A  92
HIS A  94
 None
 1.28A 5ecmA-4xq6A:
1.7		 5ecmA-4xq6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF02348
(CTP_transf_3) 		4 ALA A 127
THR A 128
TYR A 190
HIS A 227
 None
 1.28A 5ecmA-4xwiA:
undetectable		 5ecmA-4xwiA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn2 FUSOLIN

(unidentified
entomopoxvirus) 		PF03067
(LPMO_10) 		4 THR A 139
ALA A 140
TYR A 193
HIS A   1
 None
ZN  A 404 ( 4.3A)
None
ZN  A 404 (-3.0A)
 1.26A 5ecmA-4yn2A:
undetectable		 5ecmA-4yn2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9h METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
II

(Escherichia
coli) 		PF02203
(TarH) 		4 THR A  56
ALA A 100
TYR A 131
HIS A 103
 None
 1.29A 5ecmA-4z9hA:
undetectable		 5ecmA-4z9hA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5drz HIV ANTIBODY F240
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 THR L  94
THR L  93
TYR L  92
HIS L  95
 None
 1.36A 5ecmA-5drzL:
undetectable		 5ecmA-5drzL:
16.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 THR A 164
ALA A 165
THR A 166
TYR A 170
HIS A 534
 LEU  A 602 (-4.7A)
LEU  A 602 (-3.1A)
LEU  A 602 ( 3.0A)
LEU  A 602 (-4.4A)
LEU  A 602 (-4.9A)
 0.46A 5ecmA-5ecoA:
64.6		 5ecmA-5ecoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		4 THR A 296
ALA A 293
THR A 292
HIS A 278
 None
 1.01A 5ecmA-5hy4A:
undetectable		 5ecmA-5hy4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 THR A  57
ALA A 141
THR A 140
TYR A  53
 None
 1.31A 5ecmA-5k6oA:
undetectable		 5ecmA-5k6oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ket ALDO-KETO REDUCTASE
1

(Coptotermes
gestroi) 		PF00248
(Aldo_ket_red) 		4 THR A  48
ALA A  49
THR A  80
TYR A 111
 None
 1.01A 5ecmA-5ketA:
2.0		 5ecmA-5ketA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 THR A 275
ALA A 276
THR A 277
TYR A 250
 None
 1.28A 5ecmA-5l1bA:
undetectable		 5ecmA-5l1bA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 THR A 382
ALA A 383
TYR A 312
HIS A 309
 None
 1.05A 5ecmA-5nd4A:
undetectable		 5ecmA-5nd4A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 ALA A 413
THR A 412
TYR A 288
HIS A 410
 None
 0.84A 5ecmA-5te1A:
undetectable		 5ecmA-5te1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udf LIPOPROTEIN-RELEASIN
G SYSTEM
TRANSMEMBRANE
PROTEIN LOLE

(Acinetobacter
baumannii) 		PF12704
(MacB_PCD) 		4 THR A  82
ALA A  81
THR A 266
TYR A 270
 None
 1.24A 5ecmA-5udfA:
undetectable		 5ecmA-5udfA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udf LIPOPROTEIN-RELEASIN
G SYSTEM
TRANSMEMBRANE
PROTEIN LOLE

(Acinetobacter
baumannii) 		PF12704
(MacB_PCD) 		4 THR A  82
ALA A 265
THR A 266
TYR A 270
 None
 1.32A 5ecmA-5udfA:
undetectable		 5ecmA-5udfA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 THR A 275
ALA A 276
THR A 277
TYR A 250
 None
 1.40A 5ecmA-5welA:
undetectable		 5ecmA-5welA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wso NS3 HELICASE

(Pestivirus A) 		no annotation 4 THR A 350
ALA A 351
THR A 352
HIS A 324
 None
 1.21A 5ecmA-5wsoA:
undetectable		 5ecmA-5wsoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaw SODIUM CHANNEL
SUBUNIT BETA-4

(Homo sapiens) 		PF07686
(V-set) 		4 THR A 146
ALA A 145
THR A 130
HIS A 144
 None
 1.26A 5ecmA-5xawA:
undetectable		 5ecmA-5xawA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 THR A 696
THR A 692
TYR A 735
HIS A 693
 None
 1.04A 5ecmA-5ywzA:
undetectable		 5ecmA-5ywzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 THR A 310
ALA A 311
TYR A 625
HIS A 314
 None
 1.40A 5ecmA-6f8zA:
undetectable		 5ecmA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 THR A 647
ALA A 646
THR A 808
HIS A 561
 None
 1.27A 5ecmA-6fikA:
undetectable		 5ecmA-6fikA:
undetectable