SIMILAR PATTERNS OF AMINO ACIDS FOR 5ECL_D_ILED602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		4 ILE A  78
ALA A 301
VAL A 304
HIS A  70
 None
 0.73A 5eclD-1c9eA:
0.7		 5eclD-1c9eA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		4 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.62A 5eclD-1di6A:
0.0		 5eclD-1di6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 ILE A 303
THR A 285
VAL A 284
VAL A 272
 ILE  A 303 ( 0.7A)
THR  A 285 ( 0.8A)
VAL  A 284 ( 0.6A)
VAL  A 272 ( 0.6A)
 0.89A 5eclD-1fxjA:
0.0		 5eclD-1fxjA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4u NIDOGEN-1

(Mus musculus) 		PF07474
(G2F) 		5 ILE A 460
ALA A 442
THR A 441
VAL A 408
HIS A 429
 None
 1.23A 5eclD-1h4uA:
0.0		 5eclD-1h4uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 ILE A 610
ALA A 753
THR A 760
VAL A 754
VAL A 591
 None
 1.37A 5eclD-1h7wA:
0.0		 5eclD-1h7wA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		4 ILE A 398
THR A 400
VAL A 413
HIS A 405
 None
 0.83A 5eclD-1hzvA:
0.0		 5eclD-1hzvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
horikoshii) 		PF01470
(Peptidase_C15) 		4 ILE A 112
THR A 114
VAL A  75
VAL A 195
 None
 0.91A 5eclD-1iu8A:
0.6		 5eclD-1iu8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo0 TRIOSEPHOSPHATE
ISOMERASE

(Caenorhabditis
elegans) 		PF00121
(TIM) 		4 ILE A 149
ALA A 115
VAL A 122
HIS A 114
 None
 0.82A 5eclD-1mo0A:
0.6		 5eclD-1mo0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 ALA A 371
THR A 370
VAL A 383
VAL A 649
 None
 0.86A 5eclD-1qxpA:
0.0		 5eclD-1qxpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 THR A 396
VAL A 399
VAL A 324
HIS A 394
 None
 0.86A 5eclD-1r6vA:
undetectable		 5eclD-1r6vA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		4 ALA A 222
THR A 223
VAL A 226
VAL A 195
 None
 0.77A 5eclD-1s2nA:
undetectable		 5eclD-1s2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thm THERMITASE

(Thermoactinomyces
vulgaris) 		PF00082
(Peptidase_S8) 		4 ALA A 227
THR A 228
VAL A 231
VAL A 200
 None
 0.82A 5eclD-1thmA:
undetectable		 5eclD-1thmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thm THERMITASE

(Thermoactinomyces
vulgaris) 		PF00082
(Peptidase_S8) 		4 ILE A 179
ALA A 227
THR A 228
VAL A 200
 None
 0.85A 5eclD-1thmA:
undetectable		 5eclD-1thmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A  67
ALA A   6
VAL A  47
VAL A  57
 None
 0.72A 5eclD-1wwkA:
undetectable		 5eclD-1wwkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 ILE A 150
ALA A 169
THR A 222
VAL A 186
HIS A 170
 None
 1.42A 5eclD-1x0lA:
undetectable		 5eclD-1x0lA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		4 ILE A 404
ALA A 407
THR A 406
VAL A 431
 None
 0.89A 5eclD-1xr4A:
undetectable		 5eclD-1xr4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		4 ILE A 116
ALA A 121
THR A 120
VAL A  46
 None
 0.88A 5eclD-1zchA:
0.7		 5eclD-1zchA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztm FUSION GLYCOPROTEIN

(Human
respirovirus 3) 		PF00523
(Fusion_gly) 		4 ILE A 411
ALA A 377
VAL A 379
VAL A 409
 None
 0.90A 5eclD-1ztmA:
undetectable		 5eclD-1ztmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  15
VAL A  37
VAL A  81
HIS A  44
 None
 0.88A 5eclD-2bujA:
undetectable		 5eclD-2bujA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0w LMO2234 PROTEIN

(Listeria
monocytogenes) 		PF01261
(AP_endonuc_2) 		4 ALA A 269
THR A 270
VAL A 273
VAL A 249
 None
 0.91A 5eclD-2g0wA:
undetectable		 5eclD-2g0wA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpr GLUCOSE-PERMEASE IIA
COMPONENT

(Mycoplasma
capricolum) 		PF00358
(PTS_EIIA_1) 		4 ILE A 127
VAL A 115
VAL A 124
HIS A  68
 None
 0.90A 5eclD-2gprA:
undetectable		 5eclD-2gprA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		4 ALA A 104
THR A 103
VAL A 131
VAL A  95
 None
 0.86A 5eclD-2hruA:
1.0		 5eclD-2hruA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		4 ILE A 149
ALA A 115
VAL A 122
HIS A 114
 None
 0.88A 5eclD-2i9eA:
undetectable		 5eclD-2i9eA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		5 ILE A 161
ALA A  96
THR A  97
VAL A 100
HIS A  94
 None
 1.42A 5eclD-2ibpA:
undetectable		 5eclD-2ibpA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		5 ILE A 168
ALA A 180
THR A 181
VAL A 446
HIS A 419
 None
None
None
FAD  A1466 (-4.2A)
None
 1.42A 5eclD-2ivdA:
undetectable		 5eclD-2ivdA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		4 ALA A 274
THR A 275
VAL A 278
VAL A 247
 None
 0.69A 5eclD-2iy9A:
undetectable		 5eclD-2iy9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 ILE A 141
ALA A 155
VAL A 158
HIS A 145
 None
 0.82A 5eclD-2lbpA:
undetectable		 5eclD-2lbpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 ILE A 141
ALA A 155
VAL A 158
HIS A 145
 None
 0.76A 5eclD-2livA:
undetectable		 5eclD-2livA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 ALA A 735
THR A 736
VAL A 739
VAL A 679
 None
 0.90A 5eclD-2nq5A:
undetectable		 5eclD-2nq5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
megaterium;
Bacillus
megaterium) 		PF13377
(Peripla_BP_3)
PF00381
(PTS-HPr) 		4 ALA L  19
THR L  20
VAL L  23
VAL G 300
 None
 0.75A 5eclD-2nzuL:
undetectable		 5eclD-2nzuL:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
megaterium;
Bacillus
megaterium) 		PF13377
(Peripla_BP_3)
PF00381
(PTS-HPr) 		4 ILE G  85
ALA L  19
THR L  20
VAL L  23
 None
 0.84A 5eclD-2nzuG:
undetectable		 5eclD-2nzuG:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		4 ALA A  89
THR A  90
VAL A  93
VAL A  11
 None
 0.68A 5eclD-2qq1A:
undetectable		 5eclD-2qq1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ILE A 160
ALA A 302
THR A 315
VAL A 367
 None
 0.89A 5eclD-2r9vA:
undetectable		 5eclD-2r9vA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 376
THR A 375
VAL A 378
VAL A  76
 None
 0.82A 5eclD-2vd5A:
undetectable		 5eclD-2vd5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 311
ALA A 283
VAL A 285
VAL A 309
 None
None
MLY  A 255 ( 3.9A)
MLY  A 307 ( 4.1A)
 0.85A 5eclD-2vd9A:
undetectable		 5eclD-2vd9A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 ILE A   6
ALA A 183
VAL A 185
VAL A   4
 None
 0.89A 5eclD-2vz9A:
undetectable		 5eclD-2vz9A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ALA A 198
VAL A 182
VAL A 186
HIS A 206
 None
 0.88A 5eclD-2wdwA:
undetectable		 5eclD-2wdwA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.81A 5eclD-2z8eA:
undetectable		 5eclD-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.88A 5eclD-2zj8A:
undetectable		 5eclD-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		PF01425
(Amidase)
PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		4 ALA A 293
THR A 294
VAL A 297
VAL C  45
 None
 0.87A 5eclD-3al0A:
undetectable		 5eclD-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 220
ALA A 190
VAL A 194
HIS A 174
 None
None
None
FAD  A   1 (-3.9A)
 0.88A 5eclD-3fw8A:
undetectable		 5eclD-3fw8A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A   6
ALA A 183
VAL A 185
VAL A   4
 None
 0.86A 5eclD-3hhdA:
undetectable		 5eclD-3hhdA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		5 ILE A 174
ALA A 157
VAL A 167
VAL A 194
HIS A 199
 None
None
None
ACT  A 801 (-4.2A)
None
 1.42A 5eclD-3im9A:
undetectable		 5eclD-3im9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j40 GP7

(Salmonella
virus Epsilon15) 		no annotation 4 ILE A  37
ALA A  41
THR A  39
VAL A 125
 None
 0.91A 5eclD-3j40A:
undetectable		 5eclD-3j40A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		4 ALA A 341
THR A 340
VAL A 331
VAL A 383
 None
 0.91A 5eclD-3lovA:
undetectable		 5eclD-3lovA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ALA A 279
THR A 280
VAL A 283
VAL A 245
 None
 0.83A 5eclD-3lpdA:
undetectable		 5eclD-3lpdA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 ALA X 471
VAL X 472
VAL X 396
HIS X 467
 None
 0.85A 5eclD-3lxuX:
undetectable		 5eclD-3lxuX:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		5 ILE A 330
ALA A 291
THR A 294
VAL A 293
VAL A 248
 None
 1.45A 5eclD-3m6cA:
undetectable		 5eclD-3m6cA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzh PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
CRP/FNR-FAMILY)

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ILE A  96
ALA A  93
THR A  94
VAL A  99
 None
 0.91A 5eclD-3mzhA:
undetectable		 5eclD-3mzhA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		4 ILE A 170
ALA A 121
VAL A 119
VAL A  96
 None
 0.89A 5eclD-3n0vA:
undetectable		 5eclD-3n0vA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3)
no annotation 		4 ALA S  19
THR S  20
VAL S  23
VAL A 301
 None
None
SEP  S  46 ( 4.4A)
None
 0.84A 5eclD-3oqnS:
undetectable		 5eclD-3oqnS:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3)
no annotation 		4 ILE A  86
ALA S  19
THR S  20
VAL S  23
 None
None
None
SEP  S  46 ( 4.4A)
 0.85A 5eclD-3oqnA:
undetectable		 5eclD-3oqnA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oun PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		4 ILE A  99
ALA A  86
THR A  82
VAL A  88
 None
 0.79A 5eclD-3ounA:
undetectable		 5eclD-3ounA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poa PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		4 ILE A  85
ALA A  72
THR A  68
VAL A  74
 None
 0.77A 5eclD-3poaA:
undetectable		 5eclD-3poaA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		4 ILE A 205
ALA A 253
VAL A 251
VAL A 234
 None
 0.81A 5eclD-3qfwA:
undetectable		 5eclD-3qfwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 5 ILE L 332
ALA L 339
VAL L  91
VAL L 263
HIS L 338
 None
 1.21A 5eclD-3rkoL:
undetectable		 5eclD-3rkoL:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		4 ILE A 303
THR A 285
VAL A 284
VAL A 272
 None
 0.91A 5eclD-3twdA:
undetectable		 5eclD-3twdA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txy ISOCHORISMATASE
FAMILY PROTEIN
FAMILY

(Burkholderia
thailandensis) 		PF00857
(Isochorismatase) 		4 ALA A 131
THR A 132
VAL A 136
VAL A  34
 EDO  A 196 ( 3.9A)
None
None
None
 0.91A 5eclD-3txyA:
undetectable		 5eclD-3txyA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 ALA A 271
THR A 272
VAL A 275
VAL A 244
 None
 0.78A 5eclD-3vv3A:
undetectable		 5eclD-3vv3A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ILE A 356
ALA A 366
THR A 367
VAL A 370
 None
 0.55A 5eclD-3wfoA:
undetectable		 5eclD-3wfoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ILE A 356
ALA A 366
THR A 367
VAL A 370
 None
 0.59A 5eclD-3wfpA:
2.0		 5eclD-3wfpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 ILE A 358
ALA A 375
THR A 377
VAL A 376
VAL A 363
 None
 1.38A 5eclD-4b92A:
undetectable		 5eclD-4b92A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 ILE A 631
ALA A 359
VAL A 361
VAL A 652
 None
 0.90A 5eclD-4bl3A:
undetectable		 5eclD-4bl3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A 793
ALA A 806
VAL A 809
HIS A 798
 None
 0.83A 5eclD-4c3hA:
0.7		 5eclD-4c3hA:
16.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4clv NICKEL-COBALT-CADMIU
M RESISTANCE PROTEIN
NCCX

(Cupriavidus
metallidurans) 		PF13801
(Metal_resist) 		4 ALA A 101
THR A 102
VAL A 105
VAL A  19
 None
 0.75A 5eclD-4clvA:
undetectable		 5eclD-4clvA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyd PROBABLE
TRANSCRIPTION
REGULATOR

(Corynebacterium
glutamicum) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 ILE A 183
ALA A 154
THR A 156
VAL A 153
VAL A 214
 None
None
GOL  A1230 ( 4.8A)
None
None
 1.46A 5eclD-4cydA:
undetectable		 5eclD-4cydA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 206
ALA A 176
VAL A 180
HIS A 160
 None
None
None
FAD  A 501 (-3.9A)
 0.88A 5eclD-4dnsA:
undetectable		 5eclD-4dnsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus) 		PF00082
(Peptidase_S8) 		4 ALA A 224
THR A 225
VAL A 228
VAL A 195
 None
 0.83A 5eclD-4dztA:
undetectable		 5eclD-4dztA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6u ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ILE A  55
ALA A  17
THR A  36
VAL A  35
VAL A  23
 None
 1.26A 5eclD-4e6uA:
undetectable		 5eclD-4e6uA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ILE A 102
ALA A  91
THR A 139
VAL A  90
VAL A 100
 None
 1.18A 5eclD-4eziA:
undetectable		 5eclD-4eziA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ALA C 750
THR C 751
VAL C 756
VAL C 803
 None
 0.90A 5eclD-4hb4C:
undetectable		 5eclD-4hb4C:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		5 ILE A 108
ALA A 198
THR A 196
VAL A 199
VAL A 187
 None
 1.13A 5eclD-4hdtA:
undetectable		 5eclD-4hdtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		4 ALA A 205
THR A 206
VAL A 209
VAL A  43
 None
 0.80A 5eclD-4humA:
undetectable		 5eclD-4humA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itx CYSTATHIONINE
BETA-LYASE METC

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		4 ALA A 208
THR A 209
VAL A 213
VAL A 244
 None
IN5  A 401 (-3.0A)
None
None
 0.87A 5eclD-4itxA:
undetectable		 5eclD-4itxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfn GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
A
GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
B

(Lactobacillus
rhamnosus;
Lactobacillus
rhamnosus) 		PF02502
(LacAB_rpiB)
PF02502
(LacAB_rpiB) 		5 ILE B  69
ALA A  90
THR A  89
VAL A  84
HIS A  91
 RBL  B 201 ( 4.7A)
None
None
None
None
 1.23A 5eclD-4lfnB:
undetectable		 5eclD-4lfnB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE

(Streptomyces
clavuligerus) 		PF07992
(Pyr_redox_2) 		4 ILE A 257
ALA A 246
THR A 245
VAL A 115
 None
 0.92A 5eclD-4ntdA:
undetectable		 5eclD-4ntdA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis) 		PF00994
(MoCF_biosynth) 		4 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.58A 5eclD-4nwoA:
undetectable		 5eclD-4nwoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE

(Brucella
abortus) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 160
ALA A  86
THR A  87
VAL A  90
 None
PLP  A 403 ( 3.7A)
PLP  A 403 ( 4.9A)
None
 0.80A 5eclD-4qgrA:
undetectable		 5eclD-4qgrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE

(Brucella
abortus) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 160
ALA A  88
VAL A  90
VAL A 136
 None
None
None
PLP  A 403 ( 4.9A)
 0.89A 5eclD-4qgrA:
undetectable		 5eclD-4qgrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 4 ILE A  62
THR A  54
VAL A  32
HIS A  52
 None
 0.85A 5eclD-4rggA:
undetectable		 5eclD-4rggA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC

(Desulfovibrio
alaskensis) 		PF02661
(Fic) 		4 ILE A  13
ALA A 236
THR A 237
VAL A 240
 None
 0.74A 5eclD-4rglA:
undetectable		 5eclD-4rglA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ALA A 165
THR A 166
VAL A 169
VAL A 196
 None
 0.84A 5eclD-4wd1A:
0.0		 5eclD-4wd1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ALA A 186
THR A 187
VAL A 190
HIS A 183
 None
 0.71A 5eclD-4y9lA:
undetectable		 5eclD-4y9lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA

(Escherichia
coli) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		5 ILE D 275
ALA D 376
THR D 377
VAL D 380
HIS D 373
 None
 1.44A 5eclD-4yg7D:
undetectable		 5eclD-4yg7D:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zy7 UNCHARACTERIZED
PROTEIN MSMEG_5817

(Mycolicibacterium
smegmatis) 		no annotation 4 ALA A  94
THR A  95
VAL A 124
VAL A  19
 None
None
None
PEG  A 205 ( 4.2A)
 0.91A 5eclD-4zy7A:
undetectable		 5eclD-4zy7A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ab4 SCP2-THIOLASE LIKE
PROTEIN

(Trypanosoma
brucei) 		no annotation 5 ILE A 302
ALA A 200
THR A 203
VAL A 202
HIS A 145
 None
 1.28A 5eclD-5ab4A:
undetectable		 5eclD-5ab4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp)
PF01740
(STAS) 		4 ILE A 438
ALA A 453
VAL A 457
VAL A 411
 None
 0.86A 5eclD-5da0A:
0.5		 5eclD-5da0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		4 ILE A 149
ALA A 125
VAL A 127
VAL A 147
 None
 0.90A 5eclD-5dz6A:
undetectable		 5eclD-5dz6A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4s CONTACTIN-4

(Mus musculus) 		PF00041
(fn3) 		4 ILE A 605
ALA A 659
VAL A 661
VAL A 603
 None
 0.92A 5eclD-5e4sA:
undetectable		 5eclD-5e4sA:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		6 ILE A 148
ALA A 165
THR A 166
VAL A 169
VAL A 222
HIS A 534
 None
LEU  A 602 (-3.1A)
LEU  A 602 ( 3.0A)
LEU  A 602 (-4.6A)
JAA  A 601 (-4.1A)
LEU  A 602 (-4.9A)
 0.93A 5eclD-5ecoA:
56.9		 5eclD-5ecoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		4 ILE A 204
ALA A 611
THR A 612
VAL A 615
 None
 0.66A 5eclD-5ek8A:
1.9		 5eclD-5ek8A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE

(Litopenaeus
vannamei) 		PF00121
(TIM) 		4 ILE A 155
ALA A 117
VAL A 124
HIS A 116
 None
 0.90A 5eclD-5eywA:
undetectable		 5eclD-5eywA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 ILE A 959
ALA A 919
THR A 915
VAL A 921
 None
 0.89A 5eclD-5f7uA:
undetectable		 5eclD-5f7uA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		4 ALA A 345
THR A 346
VAL A 349
VAL A 306
 None
 0.90A 5eclD-5h7dA:
undetectable		 5eclD-5h7dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvc TYPE I MODULAR
POLYKETIDE SYNTHASE

(Mycobacterium
ulcerans) 		PF00550
(PP-binding) 		4 ILE A2094
ALA A2070
THR A2071
VAL A2074
 None
 0.72A 5eclD-5hvcA:
undetectable		 5eclD-5hvcA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 194
ALA A 176
THR A 178
VAL A 693
HIS A 173
 None
 1.31A 5eclD-5i4eA:
undetectable		 5eclD-5i4eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idq SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		4 ILE A  29
ALA A  32
THR A  31
VAL A  18
 None
 0.90A 5eclD-5idqA:
undetectable		 5eclD-5idqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kz5 IRON-SULFUR CLUSTER
ASSEMBLY ENZYME
ISCU, MITOCHONDRIAL

(Homo sapiens) 		PF01491
(Frataxin_Cyay) 		4 ILE a  77
ALA a 105
THR a 106
VAL a 109
 None
 0.71A 5eclD-5kz5a:
undetectable		 5eclD-5kz5a:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll1 URICASE

(Danio rerio) 		PF01014
(Uricase) 		4 ILE A 107
ALA A  74
VAL A  70
HIS A  25
 None
 0.90A 5eclD-5ll1A:
undetectable		 5eclD-5ll1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pyrobaculum
calidifontis) 		PF00490
(ALAD) 		4 ILE A 198
ALA A 122
VAL A 124
VAL A 196
 None
 0.74A 5eclD-5lzlA:
undetectable		 5eclD-5lzlA:
20.89