SIMILAR PATTERNS OF AMINO ACIDS FOR 5ECL_A_ILEA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		4 ALA A  56
VAL A  90
TYR A  88
HIS A  57
 None
None
None
0GJ  A 245 (-2.7A)
 0.98A 5eclA-1a5iA:
undetectable		 5eclA-1a5iA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 ALA A 333
THR A 334
VAL A  18
VAL A 296
 None
 0.79A 5eclA-1bwdA:
0.0		 5eclA-1bwdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 ALA A  72
VAL A  70
TYR A  63
HIS A  47
 None
 0.81A 5eclA-1ct9A:
undetectable		 5eclA-1ct9A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		4 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.52A 5eclA-1di6A:
0.0		 5eclA-1di6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ALA B 396
THR B 209
VAL B 213
VAL B 257
 None
 1.01A 5eclA-1e6vB:
0.0		 5eclA-1e6vB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 THR A 285
VAL A 284
VAL A 290
HIS A 268
 THR  A 285 ( 0.8A)
VAL  A 284 ( 0.6A)
VAL  A 290 ( 0.6A)
HIS  A 268 ( 1.0A)
 1.04A 5eclA-1fxjA:
0.6		 5eclA-1fxjA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00355
(Rieske) 		4 ALA B 118
THR B 117
VAL B  11
VAL B  47
 None
 1.04A 5eclA-1g8kB:
undetectable		 5eclA-1g8kB:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		4 ALA L 348
VAL L 350
TYR L 375
VAL L 363
 None
 1.01A 5eclA-1hfeL:
0.0		 5eclA-1hfeL:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 253
VAL A 256
TYR A 257
VAL A 204
 None
 0.74A 5eclA-1jvbA:
0.0		 5eclA-1jvbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 ALA A 371
THR A 370
VAL A 383
VAL A 649
 None
 0.75A 5eclA-1qxpA:
undetectable		 5eclA-1qxpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		4 ALA A 222
THR A 223
VAL A 226
VAL A 195
 None
 0.91A 5eclA-1s2nA:
undetectable		 5eclA-1s2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		4 ALA A  16
THR A  17
VAL A  20
VAL A  38
 None
 1.00A 5eclA-1su1A:
undetectable		 5eclA-1su1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thm THERMITASE

(Thermoactinomyces
vulgaris) 		PF00082
(Peptidase_S8) 		4 ALA A 227
THR A 228
VAL A 231
VAL A 200
 None
 0.94A 5eclA-1thmA:
undetectable		 5eclA-1thmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ALA A 174
THR A 175
VAL A 209
VAL A 122
 None
 0.94A 5eclA-1uagA:
undetectable		 5eclA-1uagA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 ALA A 251
VAL A 191
VAL A 232
HIS A 253
 None
 0.97A 5eclA-1v9kA:
undetectable		 5eclA-1v9kA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		4 THR A  66
VAL A  64
TYR A 171
VAL A  85
 None
 0.97A 5eclA-1vytA:
undetectable		 5eclA-1vytA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydu AT5G01610

(Arabidopsis
thaliana) 		PF04398
(DUF538) 		4 ALA A  72
THR A  73
VAL A  86
VAL A 160
 None
 0.98A 5eclA-1yduA:
undetectable		 5eclA-1yduA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		4 ALA A 106
THR A 107
VAL A  84
HIS A 103
 SO4  A1001 (-2.7A)
SO4  A1001 (-3.4A)
None
None
 1.05A 5eclA-1yisA:
undetectable		 5eclA-1yisA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		4 ALA A 285
THR A 326
VAL A 283
TYR A 328
 None
None
None
ODT  A1001 ( 4.0A)
 1.03A 5eclA-2bacA:
undetectable		 5eclA-2bacA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 ALA A  16
THR A  61
VAL A  60
HIS A  62
 None
 1.00A 5eclA-2e3dA:
undetectable		 5eclA-2e3dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.46A 5eclA-2ejvA:
undetectable		 5eclA-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs5 CONSERVED
HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF02622
(DUF179) 		4 ALA A  95
THR A  94
VAL A  98
VAL A 116
 None
 1.00A 5eclA-2gs5A:
undetectable		 5eclA-2gs5A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		4 ALA A 274
THR A 275
VAL A 278
VAL A 247
 None
 0.83A 5eclA-2iy9A:
undetectable		 5eclA-2iy9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
megaterium;
Bacillus
megaterium) 		PF13377
(Peripla_BP_3)
PF00381
(PTS-HPr) 		4 ALA L  19
THR L  20
VAL L  23
VAL G 300
 None
 0.83A 5eclA-2nzuL:
undetectable		 5eclA-2nzuL:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 ALA A  75
VAL A  77
TYR A  79
VAL A  54
 None
 1.04A 5eclA-2obvA:
1.1		 5eclA-2obvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvz PRPF METHYLACONITATE
ISOMERASE

(Shewanella
oneidensis) 		PF04303
(PrpF) 		4 ALA A 112
THR A 111
VAL A 114
TYR A  89
 None
 1.02A 5eclA-2pvzA:
undetectable		 5eclA-2pvzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		4 ALA A  89
THR A  90
VAL A  93
VAL A  11
 None
 0.61A 5eclA-2qq1A:
undetectable		 5eclA-2qq1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 376
THR A 375
VAL A 378
VAL A  76
 None
 0.91A 5eclA-2vd5A:
undetectable		 5eclA-2vd5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ALA A 271
VAL A 227
TYR A 228
HIS A 291
 None
 0.89A 5eclA-2veaA:
undetectable		 5eclA-2veaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		4 ALA A 361
THR A 360
VAL A 363
HIS A 311
 None
 1.04A 5eclA-2vmxA:
undetectable		 5eclA-2vmxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew E1 ENVELOPE
GLYCOPROTEIN

(Barmah Forest
virus) 		PF01589
(Alpha_E1_glycop) 		4 ALA B 357
THR B 358
VAL B 361
VAL B 367
 None
 1.00A 5eclA-2yewB:
undetectable		 5eclA-2yewB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 331
TYR A 333
VAL A 286
HIS A 289
 None
 1.00A 5eclA-2yquA:
undetectable		 5eclA-2yquA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		4 ALA A 140
THR A  98
VAL A 101
VAL A 346
 None
 1.01A 5eclA-2z5lA:
0.4		 5eclA-2z5lA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.84A 5eclA-2z8eA:
undetectable		 5eclA-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.88A 5eclA-2zj8A:
2.1		 5eclA-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		PF01425
(Amidase)
PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		4 ALA A 293
THR A 294
VAL A 297
VAL C  45
 None
 0.68A 5eclA-3al0A:
undetectable		 5eclA-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4

(Rattus
norvegicus) 		PF13848
(Thioredoxin_6) 		4 ALA A 474
VAL A 472
TYR A 417
VAL A 395
 None
 1.03A 5eclA-3ec3A:
undetectable		 5eclA-3ec3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 VAL A 350
TYR A 353
VAL A 511
HIS A 545
 None
 0.98A 5eclA-3ecqA:
undetectable		 5eclA-3ecqA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es6 PROLACTIN-INDUCIBLE
PROTEIN

(Homo sapiens) 		PF05326
(SVA) 		4 ALA B  29
THR B  69
VAL B  27
TYR B  71
 None
 0.91A 5eclA-3es6B:
undetectable		 5eclA-3es6B:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gas HEME OXYGENASE

(Helicobacter
pylori) 		PF01243
(Putative_PNPOx)
PF10615
(DUF2470) 		4 ALA A 117
VAL A 101
VAL A 147
HIS A 136
 None
 1.04A 5eclA-3gasA:
undetectable		 5eclA-3gasA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk6 INTEGRON CASSETTE
PROTEIN VCH_CASS2

(Vibrio cholerae) 		PF14526
(Cass2) 		4 ALA A  71
VAL A  69
TYR A  56
VAL A 107
 None
None
None
PE4  A6061 (-4.6A)
 0.93A 5eclA-3gk6A:
undetectable		 5eclA-3gk6A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG

(Helicobacter
pylori) 		PF00072
(Response_reg) 		4 ALA A  84
THR A  83
VAL A 104
TYR A 102
 SO4  A 126 (-3.1A)
SO4  A 126 (-3.7A)
None
None
 1.03A 5eclA-3h1gA:
undetectable		 5eclA-3h1gA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		4 ALA A 168
THR A 169
VAL A 172
VAL A  85
 None
 0.87A 5eclA-3iwjA:
undetectable		 5eclA-3iwjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 125
THR A 126
VAL A 129
VAL A 157
 None
 0.91A 5eclA-3k17A:
undetectable		 5eclA-3k17A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3d PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF08448
(PAS_4) 		4 VAL A  62
TYR A  63
VAL A  29
HIS A  36
 None
 0.93A 5eclA-3k3dA:
undetectable		 5eclA-3k3dA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		4 ALA A 181
VAL A 178
TYR A 157
HIS A 182
 None
None
None
Z97  A 767 (-4.0A)
 1.00A 5eclA-3koyA:
undetectable		 5eclA-3koyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwu MUNC13-1

(Rattus
norvegicus) 		PF00168
(C2) 		4 ALA A 689
VAL A 817
VAL A 718
HIS A 745
 None
 0.96A 5eclA-3kwuA:
undetectable		 5eclA-3kwuA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx0 UNCHARACTERIZED
PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF08448
(PAS_4) 		4 VAL X  62
TYR X  63
VAL X  29
HIS X  36
 None
 0.90A 5eclA-3kx0X:
undetectable		 5eclA-3kx0X:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE

(Arabidopsis
thaliana) 		PF05724
(TPMT) 		4 ALA A 144
VAL A 140
TYR A 172
VAL A  23
 SAH  A 300 ( 3.9A)
SAH  A 300 (-4.2A)
None
None
 0.97A 5eclA-3lccA:
undetectable		 5eclA-3lccA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ALA A 279
THR A 280
VAL A 283
VAL A 245
 None
 0.97A 5eclA-3lpdA:
undetectable		 5eclA-3lpdA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3)
no annotation 		4 ALA S  19
THR S  20
VAL S  23
VAL A 301
 None
None
SEP  S  46 ( 4.4A)
None
 0.93A 5eclA-3oqnS:
undetectable		 5eclA-3oqnS:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE

(Ovis aries) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 119
VAL A  65
VAL A  40
HIS A  68
 None
None
None
ZN  A 356 ( 3.2A)
 1.02A 5eclA-3qe3A:
undetectable		 5eclA-3qe3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		4 THR A 285
VAL A 284
VAL A 290
HIS A 268
 None
 1.02A 5eclA-3twdA:
undetectable		 5eclA-3twdA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 ALA A 271
THR A 272
VAL A 275
VAL A 244
 None
 0.88A 5eclA-3vv3A:
undetectable		 5eclA-3vv3A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz4 DOTI

(Legionella
pneumophila) 		PF11393
(T4BSS_DotI_IcmL) 		4 ALA A 138
VAL A 136
TYR A 168
VAL A 204
 None
None
MRD  A 501 ( 4.1A)
None
 0.88A 5eclA-3wz4A:
undetectable		 5eclA-3wz4A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ALA A 721
THR A 722
VAL A 633
HIS A 695
 None
EDO  A2290 (-3.1A)
None
None
 0.96A 5eclA-4a4zA:
undetectable		 5eclA-4a4zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 ALA A 482
THR A 483
VAL A 435
HIS A 454
 None
 1.03A 5eclA-4bfrA:
undetectable		 5eclA-4bfrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4clv NICKEL-COBALT-CADMIU
M RESISTANCE PROTEIN
NCCX

(Cupriavidus
metallidurans) 		PF13801
(Metal_resist) 		4 ALA A 101
THR A 102
VAL A 105
VAL A  19
 None
 0.73A 5eclA-4clvA:
undetectable		 5eclA-4clvA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d48 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Erwinia
amylovora) 		PF00483
(NTP_transferase) 		4 ALA A  16
THR A  61
VAL A  60
HIS A  62
 None
 1.02A 5eclA-4d48A:
undetectable		 5eclA-4d48A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus) 		PF00082
(Peptidase_S8) 		4 ALA A 224
THR A 225
VAL A 228
VAL A 195
 None
 0.96A 5eclA-4dztA:
undetectable		 5eclA-4dztA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgo PERIPLASMIC PROTEIN

(Legionella
pneumophila) 		PF06035
(Peptidase_C93) 		4 ALA A 163
VAL A 207
TYR A 208
HIS A 172
 None
 0.99A 5eclA-4fgoA:
undetectable		 5eclA-4fgoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2

(Mus musculus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 ALA A 134
THR A 135
VAL A  64
VAL A  36
 None
 0.95A 5eclA-4fmkA:
undetectable		 5eclA-4fmkA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.57A 5eclA-4g1pA:
1.9		 5eclA-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4got METHIONINE-BINDING
LIPOPROTEIN METQ

(Bacillus
subtilis) 		PF03180
(Lipoprotein_9) 		4 ALA A  37
VAL A  35
VAL A 109
HIS A  42
 None
 0.95A 5eclA-4gotA:
undetectable		 5eclA-4gotA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ALA C 750
THR C 751
VAL C 756
VAL C 803
 None
 0.77A 5eclA-4hb4C:
undetectable		 5eclA-4hb4C:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		4 ALA A 205
THR A 206
VAL A 209
VAL A  43
 None
 0.72A 5eclA-4humA:
undetectable		 5eclA-4humA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 196
THR A 195
TYR A 199
HIS A 165
 None
 0.91A 5eclA-4jhmA:
0.3		 5eclA-4jhmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 ALA A 773
THR A 774
VAL A 777
TYR A 778
 None
 0.74A 5eclA-4jzaA:
undetectable		 5eclA-4jzaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		4 ALA A  29
VAL A  27
VAL A 100
HIS A  34
 None
 1.04A 5eclA-4k3fA:
undetectable		 5eclA-4k3fA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 ALA A 493
THR A 494
VAL A 499
TYR A 500
 None
 0.75A 5eclA-4kf7A:
undetectable		 5eclA-4kf7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lle PROBABLE
TWO-COMPONENT SENSOR

(Pseudomonas
aeruginosa) 		PF16767
(KinB_sensor) 		4 ALA A  51
THR A  52
VAL A  55
HIS A  48
 None
 1.04A 5eclA-4lleA:
undetectable		 5eclA-4lleA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk2 HEMOGLOBIN-LIKE
PROTEIN

(Methylacidiphilum
infernorum) 		PF01152
(Bac_globin) 		4 ALA A 144
VAL A 148
VAL A 101
HIS A  70
 None
 0.97A 5eclA-4nk2A:
undetectable		 5eclA-4nk2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nss MYCOBACTERIAL
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 4 ALA A  94
THR A  95
VAL A 124
VAL A  19
 None
 0.83A 5eclA-4nssA:
undetectable		 5eclA-4nssA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN

(Synechococcus
sp.
JA-2-3B'a(2-13)) 		PF07884
(VKOR) 		4 THR A 174
VAL A 177
TYR A 178
VAL A  75
 None
 0.80A 5eclA-4nv2A:
undetectable		 5eclA-4nv2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis) 		PF00994
(MoCF_biosynth) 		4 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.53A 5eclA-4nwoA:
undetectable		 5eclA-4nwoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR

(Klebsiella
pneumoniae) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 ALA A  80
THR A  79
VAL A 100
TYR A  98
 BEF  A 301 (-3.5A)
BEF  A 301 (-3.7A)
None
None
 1.05A 5eclA-4s05A:
1.9		 5eclA-4s05A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ALA A 165
THR A 166
VAL A 169
VAL A 196
 None
 0.71A 5eclA-4wd1A:
2.5		 5eclA-4wd1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		4 ALA A 676
VAL A 671
TYR A 573
VAL A 373
 None
 1.02A 5eclA-4wiwA:
undetectable		 5eclA-4wiwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		4 ALA A 372
THR A 373
VAL A 367
TYR A 366
 None
 0.89A 5eclA-4wmjA:
0.6		 5eclA-4wmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xea PEPTIDASE M16 DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ALA A  42
THR A  43
TYR A 195
HIS A 100
 None
 1.00A 5eclA-4xeaA:
undetectable		 5eclA-4xeaA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ALA A 186
THR A 187
VAL A 190
HIS A 183
 None
 0.83A 5eclA-4y9lA:
undetectable		 5eclA-4y9lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA

(Escherichia
coli) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		4 ALA D 376
THR D 377
VAL D 380
HIS D 373
 None
 1.05A 5eclA-4yg7D:
undetectable		 5eclA-4yg7D:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zy7 UNCHARACTERIZED
PROTEIN MSMEG_5817

(Mycolicibacterium
smegmatis) 		no annotation 4 ALA A  94
THR A  95
VAL A 124
VAL A  19
 None
None
None
PEG  A 205 ( 4.2A)
 0.82A 5eclA-4zy7A:
undetectable		 5eclA-4zy7A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 VAL A 350
TYR A 353
VAL A 511
HIS A 545
 None
 1.01A 5eclA-5a55A:
undetectable		 5eclA-5a55A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		4 ALA E  56
VAL E  90
TYR E  88
HIS E  57
 None
 0.94A 5eclA-5brrE:
undetectable		 5eclA-5brrE:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c69 FUSION GLYCOPROTEIN
F0,FIBRITIN

(Enterobacteria
phage Ox2;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 ALA A 271
THR A  58
VAL A 269
VAL A 152
 None
 1.00A 5eclA-5c69A:
undetectable		 5eclA-5c69A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cu1 DMSP LYASE

(Ruegeria
pomeroyi) 		PF16867
(DMSP_lyase) 		4 ALA A 170
THR A 171
VAL A 161
HIS A 169
 None
None
None
FE  A 301 (-3.4A)
 0.95A 5eclA-5cu1A:
undetectable		 5eclA-5cu1A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp)
PF01740
(STAS) 		4 ALA A 361
THR A 362
VAL A 365
VAL A 381
 None
 1.01A 5eclA-5da0A:
undetectable		 5eclA-5da0A:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		6 ALA A 165
THR A 166
VAL A 169
TYR A 170
VAL A 222
HIS A 534
 LEU  A 602 (-3.1A)
LEU  A 602 ( 3.0A)
LEU  A 602 (-4.6A)
LEU  A 602 (-4.4A)
JAA  A 601 (-4.1A)
LEU  A 602 (-4.9A)
 0.71A 5eclA-5ecoA:
59.3		 5eclA-5ecoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iof SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp) 		4 ALA A 361
THR A 362
VAL A 365
VAL A 381
 None
 1.01A 5eclA-5iofA:
undetectable		 5eclA-5iofA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlu ADHESIN COMPETENCE
REPRESSOR

(Streptococcus
pyogenes) 		PF01047
(MarR) 		4 THR A 115
VAL A 118
TYR A 119
HIS A 111
 None
 0.98A 5eclA-5jluA:
undetectable		 5eclA-5jluA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG

(Homo sapiens) 		PF04821
(TIMELESS) 		4 THR A  70
VAL A 132
VAL A  82
HIS A  72
 None
 0.98A 5eclA-5mqiA:
undetectable		 5eclA-5mqiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdg FUSION GLYCOPROTEIN
F0,FIBRITIN

(Bovine
orthopneumovirus;
Enterobacteria
phage T4 sensu
lato) 		PF00523
(Fusion_gly)
PF07921
(Fibritin_C) 		4 ALA A 298
THR A  58
VAL A 296
VAL A 179
 None
 1.04A 5eclA-5tdgA:
undetectable		 5eclA-5tdgA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		5 ALA A 413
THR A 412
VAL A 415
TYR A 288
HIS A 410
 None
 1.42A 5eclA-5te1A:
0.9		 5eclA-5te1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ALA A1457
THR A1456
VAL A1459
HIS A1485
 None
 0.95A 5eclA-5ujaA:
undetectable		 5eclA-5ujaA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqi PHOSPHOSUGAR
ISOMERASE

(Escherichia
coli) 		no annotation 4 ALA A 108
THR A 109
VAL A  81
VAL A  51
 None
 1.01A 5eclA-5uqiA:
undetectable		 5eclA-5uqiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyr BACTERIOPHYTOCHROME

(Xanthomonas
campestris) 		no annotation 4 ALA A 263
THR A 262
VAL A 219
HIS A 283
 None
 0.97A 5eclA-5uyrA:
undetectable		 5eclA-5uyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8q BIS3 BIPHENYL
SYNTHASE

(Malus domestica) 		no annotation 4 ALA A 323
THR A 324
VAL A 327
VAL A 367
 None
 0.90A 5eclA-5w8qA:
undetectable		 5eclA-5w8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 4 ALA A 342
VAL A 346
TYR A 347
VAL A 227
 None
 0.90A 5eclA-5wa3A:
2.3		 5eclA-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 THR M 340
VAL M 343
TYR M 344
HIS M 382
 None
 0.98A 5eclA-5wc8M:
undetectable		 5eclA-5wc8M:
21.10