SIMILAR PATTERNS OF AMINO ACIDS FOR 5ECK_A_ILEA601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ALA C 405
THR C 408
TYR C 407
VAL C  76
HIS C  78
 None
 1.32A 5eckA-1a5lC:
0.0		 5eckA-1a5lC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 ALA A 333
THR A 334
VAL A  18
VAL A 296
 None
 1.00A 5eckA-1bwdA:
0.7		 5eckA-1bwdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2y PROTEIN (LUMAZINE
SYNTHASE)

(Spinacia
oleracea) 		PF00885
(DMRL_synthase) 		4 ALA A  74
VAL A  76
VAL A  44
HIS A  73
 None
 0.97A 5eckA-1c2yA:
undetectable		 5eckA-1c2yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H

(Streptomyces
plicatus) 		PF00704
(Glyco_hydro_18) 		4 ALA A 253
THR A 252
VAL A 255
TYR A  28
 ALA  A 253 ( 0.0A)
THR  A 252 ( 0.8A)
VAL  A 255 ( 0.6A)
TYR  A  28 ( 1.3A)
 0.97A 5eckA-1c8xA:
undetectable		 5eckA-1c8xA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 ALA A  72
VAL A  70
TYR A  63
HIS A  47
 None
 0.80A 5eckA-1ct9A:
0.0		 5eckA-1ct9A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		4 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.74A 5eckA-1di6A:
undetectable		 5eckA-1di6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		4 ALA A1051
THR A1054
VAL A1094
HIS A1026
 None
 1.05A 5eckA-1fx2A:
undetectable		 5eckA-1fx2A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		4 ALA L 348
VAL L 350
TYR L 375
VAL L 363
 None
 0.94A 5eckA-1hfeL:
undetectable		 5eckA-1hfeL:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 253
VAL A 256
TYR A 257
VAL A 204
 None
 0.68A 5eckA-1jvbA:
undetectable		 5eckA-1jvbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 ALA A 704
VAL A 916
TYR A 706
VAL A 863
 None
 0.94A 5eckA-1kspA:
2.9		 5eckA-1kspA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 THR A  43
VAL A  45
VAL A 260
HIS A  40
 None
 0.85A 5eckA-1li7A:
1.2		 5eckA-1li7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 ALA A 371
THR A 370
VAL A 383
VAL A 649
 None
 0.77A 5eckA-1qxpA:
undetectable		 5eckA-1qxpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		4 ALA A 222
THR A 223
VAL A 226
VAL A 195
 None
 0.99A 5eckA-1s2nA:
undetectable		 5eckA-1s2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ALA B  41
THR B  30
VAL B  25
HIS B  42
 None
 1.00A 5eckA-1skyB:
2.1		 5eckA-1skyB:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 ALA A 251
VAL A 191
VAL A 232
HIS A 253
 None
 1.01A 5eckA-1v9kA:
undetectable		 5eckA-1v9kA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 ALA A 352
THR A 351
VAL A 249
VAL A 379
 None
 1.02A 5eckA-1yzyA:
undetectable		 5eckA-1yzyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.50A 5eckA-2ejvA:
undetectable		 5eckA-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 ALA A  75
THR A  74
VAL A  97
VAL A  43
 None
 0.96A 5eckA-2fpgA:
1.8		 5eckA-2fpgA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0w LMO2234 PROTEIN

(Listeria
monocytogenes) 		PF01261
(AP_endonuc_2) 		4 ALA A 269
THR A 270
VAL A 273
VAL A 249
 None
 0.98A 5eckA-2g0wA:
undetectable		 5eckA-2g0wA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ALA A 260
THR A 262
VAL A 264
VAL A 307
 None
 1.03A 5eckA-2hjsA:
undetectable		 5eckA-2hjsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		4 ALA A 104
THR A 103
VAL A 131
VAL A  95
 None
 0.82A 5eckA-2hruA:
undetectable		 5eckA-2hruA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 ALA A 735
THR A 736
VAL A 739
VAL A 679
 None
 1.00A 5eckA-2nq5A:
undetectable		 5eckA-2nq5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyi UNKNOWN PROTEIN

(Galdieria
sulphuraria) 		PF13740
(ACT_6) 		4 ALA A 109
THR A 111
VAL A 113
VAL A  98
 None
 1.01A 5eckA-2nyiA:
2.6		 5eckA-2nyiA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvz PRPF METHYLACONITATE
ISOMERASE

(Shewanella
oneidensis) 		PF04303
(PrpF) 		4 ALA A 112
THR A 111
VAL A 114
TYR A  89
 None
 1.07A 5eckA-2pvzA:
1.6		 5eckA-2pvzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ALA A 100
THR A  99
VAL A 129
VAL A 114
 None
 1.00A 5eckA-2q1yA:
2.7		 5eckA-2q1yA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		4 ALA A  89
THR A  90
VAL A  93
VAL A  11
 None
 0.85A 5eckA-2qq1A:
undetectable		 5eckA-2qq1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 376
THR A 375
VAL A 378
VAL A  76
 None
 0.84A 5eckA-2vd5A:
undetectable		 5eckA-2vd5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ALA A 271
VAL A 227
TYR A 228
HIS A 291
 None
 0.90A 5eckA-2veaA:
2.1		 5eckA-2veaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		4 ALA A 495
THR A 494
VAL A 497
HIS A 491
 None
 1.05A 5eckA-2vl7A:
2.8		 5eckA-2vl7A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ALA A 198
VAL A 182
VAL A 186
HIS A 206
 None
 0.93A 5eckA-2wdwA:
undetectable		 5eckA-2wdwA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew E1 ENVELOPE
GLYCOPROTEIN

(Barmah Forest
virus) 		PF01589
(Alpha_E1_glycop) 		4 ALA B 357
THR B 358
VAL B 361
VAL B 367
 None
 0.92A 5eckA-2yewB:
undetectable		 5eckA-2yewB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		4 ALA A 167
THR A 168
VAL A 170
VAL A 258
 None
 0.99A 5eckA-2yzwA:
undetectable		 5eckA-2yzwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.94A 5eckA-2z8eA:
undetectable		 5eckA-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.85A 5eckA-2zj8A:
undetectable		 5eckA-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		PF01425
(Amidase)
PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		4 ALA A 293
THR A 294
VAL A 297
VAL C  45
 None
 0.86A 5eckA-3al0A:
undetectable		 5eckA-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es6 PROLACTIN-INDUCIBLE
PROTEIN

(Homo sapiens) 		PF05326
(SVA) 		4 ALA B  29
THR B  69
VAL B  27
TYR B  71
 None
 0.93A 5eckA-3es6B:
undetectable		 5eckA-3es6B:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		4 ALA A  15
THR A  16
VAL A  19
VAL A  61
 None
 0.95A 5eckA-3h4yA:
undetectable		 5eckA-3h4yA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL

(Schizosaccharomyces
pombe) 		PF00682
(HMGL-like) 		4 ALA A 148
THR A 149
VAL A 151
VAL A 184
 None
 1.03A 5eckA-3ivuA:
undetectable		 5eckA-3ivuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		4 ALA A 168
THR A 169
VAL A 172
VAL A  85
 None
 1.01A 5eckA-3iwjA:
undetectable		 5eckA-3iwjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		4 ALA A 465
VAL A 469
VAL A 280
HIS A 462
 None
 1.07A 5eckA-3j09A:
2.0		 5eckA-3j09A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 125
THR A 126
VAL A 129
VAL A 157
 None
 1.00A 5eckA-3k17A:
undetectable		 5eckA-3k17A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3d PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF08448
(PAS_4) 		4 VAL A  62
TYR A  63
VAL A  29
HIS A  36
 None
 0.87A 5eckA-3k3dA:
undetectable		 5eckA-3k3dA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		4 ALA A 181
VAL A 178
TYR A 157
HIS A 182
 None
None
None
Z97  A 767 (-4.0A)
 0.94A 5eckA-3koyA:
undetectable		 5eckA-3koyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwu MUNC13-1

(Rattus
norvegicus) 		PF00168
(C2) 		4 ALA A 689
VAL A 817
VAL A 718
HIS A 745
 None
 0.95A 5eckA-3kwuA:
undetectable		 5eckA-3kwuA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx0 UNCHARACTERIZED
PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF08448
(PAS_4) 		4 VAL X  62
TYR X  63
VAL X  29
HIS X  36
 None
 0.90A 5eckA-3kx0X:
undetectable		 5eckA-3kx0X:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		4 ALA A 341
THR A 340
VAL A 331
VAL A 383
 None
 0.97A 5eckA-3lovA:
undetectable		 5eckA-3lovA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyy ADHESION EXOPROTEIN

(Pediococcus
pentosaceus) 		no annotation 4 ALA A   3
THR A   4
VAL A  89
VAL A  51
 None
 0.99A 5eckA-3lyyA:
undetectable		 5eckA-3lyyA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 4 ALA L  42
THR L  45
VAL L  44
VAL L 128
 None
 1.02A 5eckA-3rkoL:
undetectable		 5eckA-3rkoL:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1

(Burkholderia
ambifaria) 		PF00793
(DAHP_synth_1) 		4 ALA A 199
THR A 200
VAL A 203
VAL A 254
 None
 0.86A 5eckA-3t4cA:
undetectable		 5eckA-3t4cA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4u HEMOGLOBIN SUBUNIT
ZETA

(Homo sapiens) 		PF00042
(Globin) 		4 THR A  39
TYR A  42
VAL A  96
HIS A  36
 HEM  A 201 ( 4.6A)
HEM  A 201 (-4.3A)
None
None
 1.03A 5eckA-3w4uA:
2.3		 5eckA-3w4uA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ALA A 721
THR A 722
VAL A 633
HIS A 695
 None
EDO  A2290 (-3.1A)
None
None
 0.90A 5eckA-4a4zA:
undetectable		 5eckA-4a4zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		4 ALA A 497
THR A 496
VAL A 499
TYR A  92
 FAD  A 551 ( 4.5A)
None
None
None
 1.03A 5eckA-4c3yA:
undetectable		 5eckA-4c3yA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4clv NICKEL-COBALT-CADMIU
M RESISTANCE PROTEIN
NCCX

(Cupriavidus
metallidurans) 		PF13801
(Metal_resist) 		4 ALA A 101
THR A 102
VAL A 105
VAL A  19
 None
 0.88A 5eckA-4clvA:
undetectable		 5eckA-4clvA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw1 MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B14

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 201
VAL A 257
TYR A 268
HIS A 202
 None
 1.07A 5eckA-4cw1A:
undetectable		 5eckA-4cw1A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 ALA A 284
VAL A 389
TYR A 390
VAL A 292
 None
 1.07A 5eckA-4fddA:
undetectable		 5eckA-4fddA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgo PERIPLASMIC PROTEIN

(Legionella
pneumophila) 		PF06035
(Peptidase_C93) 		4 ALA A 163
VAL A 207
TYR A 208
HIS A 172
 None
 0.96A 5eckA-4fgoA:
undetectable		 5eckA-4fgoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.59A 5eckA-4g1pA:
undetectable		 5eckA-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6q PUTATIVE
UNCHARACTERIZED
PROTEIN

(Kribbella
flavida) 		PF12840
(HTH_20) 		4 ALA A  68
THR A  79
VAL A  66
TYR A  80
 None
 0.84A 5eckA-4g6qA:
undetectable		 5eckA-4g6qA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 VAL A 469
TYR A 459
VAL A 452
HIS A 456
 None
 0.90A 5eckA-4h1sA:
undetectable		 5eckA-4h1sA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ALA C 750
THR C 751
VAL C 756
VAL C 803
 None
 0.84A 5eckA-4hb4C:
undetectable		 5eckA-4hb4C:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		4 ALA A 205
THR A 206
VAL A 209
VAL A  43
 None
 0.83A 5eckA-4humA:
undetectable		 5eckA-4humA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 ALA A 159
THR A 160
VAL A 162
VAL A 180
 NAI  A 502 ( 4.7A)
None
None
None
 1.06A 5eckA-4im7A:
undetectable		 5eckA-4im7A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 ALA A 773
THR A 774
VAL A 777
TYR A 778
 None
 0.82A 5eckA-4jzaA:
1.3		 5eckA-4jzaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ALA A 316
THR A 315
VAL A 259
VAL A 384
 None
 1.07A 5eckA-4lvcA:
2.6		 5eckA-4lvcA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nss MYCOBACTERIAL
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 4 ALA A  94
THR A  95
VAL A 124
VAL A  19
 None
 0.90A 5eckA-4nssA:
undetectable		 5eckA-4nssA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntl LIPOPROTEIN, YAEC
FAMILY

(Enterococcus
faecalis) 		PF03180
(Lipoprotein_9) 		4 ALA A 250
THR A 252
VAL A 256
VAL A 232
 None
 0.92A 5eckA-4ntlA:
undetectable		 5eckA-4ntlA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN

(Synechococcus
sp.
JA-2-3B'a(2-13)) 		PF07884
(VKOR) 		4 THR A 174
VAL A 177
TYR A 178
VAL A  75
 None
 0.93A 5eckA-4nv2A:
undetectable		 5eckA-4nv2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis) 		PF00994
(MoCF_biosynth) 		4 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.77A 5eckA-4nwoA:
undetectable		 5eckA-4nwoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		4 ALA A1133
VAL A1131
VAL A1157
HIS A1121
 None
 1.01A 5eckA-4pk1A:
undetectable		 5eckA-4pk1A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unw H3 HAEMAGGLUTININ
HA1 CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 THR A 155
VAL A 130
TYR A 161
VAL A 252
 None
 1.06A 5eckA-4unwA:
undetectable		 5eckA-4unwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ALA A 165
THR A 166
VAL A 169
VAL A 196
 None
 0.77A 5eckA-4wd1A:
1.7		 5eckA-4wd1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		4 ALA A 372
THR A 373
VAL A 367
TYR A 366
 None
 0.99A 5eckA-4wmjA:
3.2		 5eckA-4wmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaa PUTATIVE OXYGENASE

(Streptomyces
viridochromogenes) 		PF05721
(PhyH) 		4 ALA A 155
VAL A 178
VAL A 188
HIS A 196
 None
None
None
NI  A 301 (-3.4A)
 1.04A 5eckA-4xaaA:
undetectable		 5eckA-4xaaA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 ALA A 328
VAL A 331
TYR A 332
HIS A 438
 40V  A1001 ( 4.6A)
None
40V  A1001 (-3.8A)
40V  A1001 (-3.6A)
 1.06A 5eckA-4xiiA:
undetectable		 5eckA-4xiiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ALA A 186
THR A 187
VAL A 190
HIS A 183
 None
 1.00A 5eckA-4y9lA:
undetectable		 5eckA-4y9lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywj 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 ALA A  32
THR A  31
VAL A  57
VAL A  21
 None
 1.00A 5eckA-4ywjA:
undetectable		 5eckA-4ywjA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zy7 UNCHARACTERIZED
PROTEIN MSMEG_5817

(Mycolicibacterium
smegmatis) 		no annotation 4 ALA A  94
THR A  95
VAL A 124
VAL A  19
 None
None
None
PEG  A 205 ( 4.2A)
 0.96A 5eckA-4zy7A:
undetectable		 5eckA-4zy7A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		4 ALA A 151
VAL A 153
VAL A  59
HIS A 150
 None
 1.06A 5eckA-5c2iA:
undetectable		 5eckA-5c2iA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ALA A 162
THR A 163
VAL A 165
VAL A  23
 None
 0.95A 5eckA-5cwaA:
undetectable		 5eckA-5cwaA:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		6 ALA A 165
THR A 166
VAL A 169
TYR A 170
VAL A 222
HIS A 534
 LEU  A 602 (-3.1A)
LEU  A 602 ( 3.0A)
LEU  A 602 (-4.6A)
LEU  A 602 (-4.4A)
JAA  A 601 (-4.1A)
LEU  A 602 (-4.9A)
 0.53A 5eckA-5ecoA:
63.6		 5eckA-5ecoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA

(Homo sapiens;
Arcobacter
butzleri) 		PF00520
(Ion_trans) 		4 ALA A1615
THR A1614
VAL A1613
VAL A1574
 None
 1.06A 5eckA-5ek0A:
undetectable		 5eckA-5ek0A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 ALA C 200
THR C 168
VAL C 202
TYR C 170
 None
 1.01A 5eckA-5flzC:
1.2		 5eckA-5flzC:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		4 ALA A  49
THR A  39
VAL A  47
TYR A  40
 None
NA  A 502 (-3.8A)
None
None
 0.91A 5eckA-5gtkA:
undetectable		 5eckA-5gtkA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		4 ALA A 345
THR A 346
VAL A 349
VAL A 306
 None
 0.88A 5eckA-5h7dA:
undetectable		 5eckA-5h7dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ALA A  45
THR A  46
VAL A  48
VAL A 144
 None
None
None
GOL  A 401 (-4.9A)
 1.05A 5eckA-5hc4A:
undetectable		 5eckA-5hc4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 ALA A 186
THR A 187
VAL A 193
HIS A 185
 None
 0.92A 5eckA-5husA:
undetectable		 5eckA-5husA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcd CHITIN
ELICITOR-BINDING
PROTEIN

(Oryza sativa) 		PF01476
(LysM) 		4 ALA A  84
THR A  54
VAL A  86
VAL A  59
 None
 0.91A 5eckA-5jcdA:
undetectable		 5eckA-5jcdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jce CHITIN
ELICITOR-BINDING
PROTEIN

(Oryza sativa) 		PF01476
(LysM) 		4 ALA A  84
THR A  54
VAL A  86
VAL A  59
 None
 0.94A 5eckA-5jceA:
undetectable		 5eckA-5jceA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je3 METHYL TRANSFERASE

(Burkholderia
glumae) 		PF13847
(Methyltransf_31) 		4 THR A  30
VAL A  28
VAL A 141
HIS A  33
 None
 1.07A 5eckA-5je3A:
undetectable		 5eckA-5je3A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlu ADHESIN COMPETENCE
REPRESSOR

(Streptococcus
pyogenes) 		PF01047
(MarR) 		4 THR A 115
VAL A 118
TYR A 119
HIS A 111
 None
 1.01A 5eckA-5jluA:
undetectable		 5eckA-5jluA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II
PROTEIN D1

(Arabidopsis
thaliana) 		PF00124
(Photo_RC) 		4 ALA A 153
THR A 155
VAL A 157
VAL A 123
 CLA  A 402 ( 3.7A)
None
None
PHO  A 404 ( 4.7A)
 1.04A 5eckA-5mdxA:
undetectable		 5eckA-5mdxA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L10

(Mycolicibacterium
smegmatis) 		PF00466
(Ribosomal_L10) 		4 ALA I  80
THR I  23
VAL I  82
VAL I 120
 None
 0.90A 5eckA-5o60I:
undetectable		 5eckA-5o60I:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 4 ALA A 522
VAL A 526
TYR A 527
VAL A  89
 None
 0.93A 5eckA-5odoA:
undetectable		 5eckA-5odoA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 ALA A 413
THR A 412
TYR A 288
HIS A 410
 None
 0.76A 5eckA-5te1A:
undetectable		 5eckA-5te1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ALA A1457
THR A1456
VAL A1459
HIS A1485
 None
 0.93A 5eckA-5ujaA:
undetectable		 5eckA-5ujaA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 232
THR A 231
VAL A 106
VAL A  41
HIS A 233
 None
 1.36A 5eckA-5uxnA:
undetectable		 5eckA-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyr BACTERIOPHYTOCHROME

(Xanthomonas
campestris) 		no annotation 4 ALA A 263
THR A 262
VAL A 219
HIS A 283
 None
 1.02A 5eckA-5uyrA:
undetectable		 5eckA-5uyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 4 ALA A 342
VAL A 346
TYR A 347
VAL A 170
 None
 0.95A 5eckA-5wa3A:
2.6		 5eckA-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 4 ALA A 342
VAL A 346
TYR A 347
VAL A 227
 None
 0.81A 5eckA-5wa3A:
2.6		 5eckA-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 THR M 340
VAL M 343
TYR M 344
HIS M 382
 None
 0.96A 5eckA-5wc8M:
undetectable		 5eckA-5wc8M:
21.10