SIMILAR PATTERNS OF AMINO ACIDS FOR 5EB5_B_010B607

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 454
ALA A 450
VAL A 382
LEU A 490
VAL A 462
 None
 1.41A 5eb5B-1e8cA:
undetectable		 5eb5B-1e8cA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00977
(His_biosynth) 		5 ALA F  36
VAL F  18
LEU F  78
VAL F  13
HIS F 229
 None
 1.11A 5eb5B-1ka9F:
undetectable		 5eb5B-1ka9F:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		5 ALA A  96
ALA A 100
VAL A 131
LEU A 119
VAL A 133
 None
 1.33A 5eb5B-1m3uA:
undetectable		 5eb5B-1m3uA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz9 HYPOTHETICAL PROTEIN
AQ_1354

(Aquifex
aeolicus) 		PF02130
(UPF0054) 		5 ALA A  32
ALA A  29
VAL A  45
LEU A 121
VAL A  87
 None
 1.12A 5eb5B-1oz9A:
undetectable		 5eb5B-1oz9A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 VAL A 501
LEU A 434
VAL A 483
TYR A 527
TRP A 526
 None
 1.39A 5eb5B-1qb4A:
undetectable		 5eb5B-1qb4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 ALA X 377
ARG X 408
ALA X 381
VAL X 401
VAL X 429
 None
 1.32A 5eb5B-1r6bX:
undetectable		 5eb5B-1r6bX:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		5 ALA A 229
ALA A 232
VAL A 166
LEU A 402
VAL A 271
 None
 1.26A 5eb5B-1r6vA:
undetectable		 5eb5B-1r6vA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A  57
ALA A  54
VAL A  77
LEU A  69
VAL A  75
 None
 1.50A 5eb5B-1ub7A:
undetectable		 5eb5B-1ub7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wly 2-HALOACRYLATE
REDUCTASE

(Burkholderia
sp. WS) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  69
ALA A  37
VAL A 328
LEU A 118
HIS A 122
 ALA  A  69 ( 0.0A)
ALA  A  37 ( 0.0A)
VAL  A 328 ( 0.6A)
LEU  A 118 ( 0.6A)
HIS  A 122 ( 1.0A)
 1.44A 5eb5B-1wlyA:
undetectable		 5eb5B-1wlyA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ALA A  18
ALA A  20
VAL A  25
VAL A   3
TRP A 118
 None
 1.05A 5eb5B-1zejA:
2.9		 5eb5B-1zejA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ALA A  18
VAL A  25
LEU A 148
VAL A   3
TRP A 118
 None
 1.36A 5eb5B-1zejA:
2.9		 5eb5B-1zejA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 225
ALA A 221
VAL A 410
LEU A 189
VAL A 353
 None
 1.21A 5eb5B-1zk7A:
10.6		 5eb5B-1zk7A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ALA A 392
ALA A 388
LEU A 355
HIS A 352
VAL A 419
 None
 1.31A 5eb5B-2cxeA:
undetectable		 5eb5B-2cxeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 ALA A 235
ALA A 232
VAL A 225
LEU A 245
VAL A 194
 None
 1.27A 5eb5B-2d4eA:
undetectable		 5eb5B-2d4eA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		5 ALA A 357
VAL A 329
HIS A 324
VAL A 328
TYR A 368
 None
None
None
None
37T  A 502 (-3.1A)
 1.17A 5eb5B-2efjA:
undetectable		 5eb5B-2efjA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		5 ALA A 224
ALA A 281
VAL A 263
LEU A 289
VAL A 257
 None
 1.31A 5eb5B-2fv0A:
undetectable		 5eb5B-2fv0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		5 ALA A 306
ALA A 308
VAL A 127
LEU A 284
VAL A 143
 None
 1.29A 5eb5B-2iv0A:
undetectable		 5eb5B-2iv0A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mra DE NOVO DESIGNED
PROTEIN OR459

(synthetic
construct) 		no annotation 5 ALA A  41
ALA A  44
VAL A  56
LEU A  25
TRP A  76
 None
 1.10A 5eb5B-2mraA:
undetectable		 5eb5B-2mraA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		5 ALA A 245
ALA A 243
VAL A  19
VAL A  17
TRP A 419
 None
 1.37A 5eb5B-2o0xA:
undetectable		 5eb5B-2o0xA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 ALA A 520
ALA A 524
VAL A 530
LEU A 588
VAL A 508
 None
 1.33A 5eb5B-2o1xA:
undetectable		 5eb5B-2o1xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 139
ALA A 326
VAL A 149
LEU A 320
VAL A 334
 None
 1.46A 5eb5B-2og9A:
undetectable		 5eb5B-2og9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p26 INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin) 		5 ALA A  91
ALA A  63
VAL A  81
LEU A 356
VAL A 417
 None
 1.08A 5eb5B-2p26A:
undetectable		 5eb5B-2p26A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 378
ALA A 375
VAL A 540
LEU A 383
VAL A 470
 None
 1.21A 5eb5B-2q27A:
undetectable		 5eb5B-2q27A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 224
ALA A 220
VAL A 416
LEU A 187
VAL A 359
 None
 1.23A 5eb5B-2qaeA:
11.6		 5eb5B-2qaeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		5 ALA A 512
VAL A 453
HIS A 332
VAL A 424
TYR A 422
 None
None
ZN  A1566 (-3.4A)
None
None
 1.48A 5eb5B-2w9mA:
undetectable		 5eb5B-2w9mA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9k PROTEIN INVG

(Salmonella
enterica) 		no annotation 5 ALA A  48
ALA A  50
VAL A  57
LEU A  42
VAL A  59
 None
 1.08A 5eb5B-2y9kA:
undetectable		 5eb5B-2y9kA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		5 ALA A  28
ALA A  24
VAL A   7
LEU A  47
VAL A  80
 None
 1.26A 5eb5B-2zvbA:
undetectable		 5eb5B-2zvbA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtt NADP OXIDOREDUCTASE

(Arthrobacter
sp. FB24) 		PF03807
(F420_oxidored) 		5 ALA A  18
ALA A  16
VAL A   5
LEU A 180
VAL A  76
 None
 1.17A 5eb5B-3dttA:
undetectable		 5eb5B-3dttA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
pseudomallei) 		PF02548
(Pantoate_transf) 		5 ALA A  94
ALA A  98
VAL A 129
LEU A 117
VAL A 131
 None
 1.37A 5eb5B-3ez4A:
undetectable		 5eb5B-3ez4A:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		6 ALA A 111
ARG A 300
HIS A 357
TYR A 457
TRP A 458
HIS A 497
 FAD  A 522 ( 3.0A)
None
HBX  A 530 (-4.5A)
HBX  A 530 (-4.3A)
FAD  A 522 (-3.9A)
HBX  A 530 ( 3.9A)
 0.36A 5eb5B-3gdnA:
64.8		 5eb5B-3gdnA:
74.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h86 ADENYLATE KINASE

(Methanococcus
maripaludis) 		no annotation 5 ALA B  74
ALA B  42
VAL B  37
LEU B 105
VAL B  89
 None
 1.23A 5eb5B-3h86B:
undetectable		 5eb5B-3h86B:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 131
ALA A 133
VAL A 368
LEU A 114
VAL A 139
 None
 1.39A 5eb5B-3jtmA:
undetectable		 5eb5B-3jtmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngf AP ENDONUCLEASE,
FAMILY 2

(Brucella
abortus) 		PF01261
(AP_endonuc_2) 		5 ALA A  74
ALA A 104
VAL A 139
LEU A 163
VAL A 172
 None
 0.98A 5eb5B-3ngfA:
undetectable		 5eb5B-3ngfA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1

(Saccharomyces
cerevisiae) 		PF01680
(SOR_SNZ) 		5 ALA A 254
ALA A 221
VAL A 232
LEU A 247
VAL A 234
 None
 1.12A 5eb5B-3o07A:
undetectable		 5eb5B-3o07A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oru DUF1989 FAMILY
PROTEIN

(Ruegeria sp.
TM1040) 		PF09347
(DUF1989) 		5 ALA A 153
ARG A  47
ALA A 150
VAL A 203
VAL A 201
 None
 1.34A 5eb5B-3oruA:
undetectable		 5eb5B-3oruA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 ALA A 294
ALA A 255
VAL A 233
LEU A 285
VAL A 235
 None
 1.48A 5eb5B-3qp9A:
undetectable		 5eb5B-3qp9A:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A 111
ARG A 301
HIS A 358
VAL A 360
HIS A 460
 FAD  A 773 (-3.0A)
None
None
None
FAD  A 773 ( 4.4A)
 1.45A 5eb5B-3redA:
64.1		 5eb5B-3redA:
76.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		7 ALA A 111
ARG A 301
HIS A 358
VAL A 360
TYR A 458
TRP A 459
HIS A 498
 FAD  A 773 (-3.0A)
None
None
None
None
FAD  A 773 (-3.8A)
FAD  A 773 (-4.4A)
 0.40A 5eb5B-3redA:
64.1		 5eb5B-3redA:
76.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2

(Homo sapiens) 		PF04495
(GRASP55_65) 		5 ALA A 124
ALA A 127
VAL A 176
LEU A 149
VAL A 165
 None
 1.45A 5eb5B-3rleA:
undetectable		 5eb5B-3rleA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu B2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		5 ALA C  33
ALA C  35
VAL C 120
VAL C 124
TRP C  21
 None
 1.42A 5eb5B-3wcuC:
undetectable		 5eb5B-3wcuC:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		5 ALA A 204
ARG A 209
ALA A 147
VAL A 151
LEU A 287
 None
 1.41A 5eb5B-3wh7A:
undetectable		 5eb5B-3wh7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj7 PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF01370
(Epimerase) 		5 ALA A  25
VAL A  81
LEU A  53
VAL A  15
HIS A 224
 None
 1.27A 5eb5B-3wj7A:
undetectable		 5eb5B-3wj7A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE

(Escherichia
coli) 		no annotation 5 ALA B 256
ALA B 260
VAL B 270
LEU B   4
VAL B 280
 None
 1.27A 5eb5B-3wlxB:
1.0		 5eb5B-3wlxB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 ALA L 163
ALA L 165
VAL L 193
LEU L   4
VAL L 175
 None
 1.40A 5eb5B-3wxrL:
undetectable		 5eb5B-3wxrL:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		5 ALA A 301
VAL A 240
LEU A 230
VAL A 185
TRP A 281
 None
 1.45A 5eb5B-4c4aA:
undetectable		 5eb5B-4c4aA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		5 ALA B 160
ALA B 140
VAL B 123
LEU B 102
VAL B  88
 None
 1.13A 5eb5B-4ci2B:
undetectable		 5eb5B-4ci2B:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		5 ALA A 229
ARG A 257
ALA A 217
VAL A 242
VAL A 250
 None
 1.23A 5eb5B-4e3aA:
undetectable		 5eb5B-4e3aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		5 ALA A 312
ALA A 290
VAL A 163
LEU A  25
VAL A  17
 None
 1.10A 5eb5B-4k5rA:
12.3		 5eb5B-4k5rA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhw GLUTATHIONE
S-TRANSFERASE

(Sinorhizobium
meliloti) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 ALA A 148
VAL A 113
LEU A 198
VAL A 177
TRP A 197
 None
 1.45A 5eb5B-4nhwA:
undetectable		 5eb5B-4nhwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE

(Streptomyces
clavuligerus) 		PF07992
(Pyr_redox_2) 		5 ALA A 296
ARG A 112
ALA A 293
VAL A 114
LEU A 301
 None
 1.46A 5eb5B-4ntdA:
12.7		 5eb5B-4ntdA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o94 TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		5 ALA A  52
VAL A  62
LEU A 248
VAL A  29
TRP A 245
 None
 1.21A 5eb5B-4o94A:
undetectable		 5eb5B-4o94A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 319
ALA A 247
VAL A 242
LEU A 148
HIS A 156
 None
 1.44A 5eb5B-4o99A:
undetectable		 5eb5B-4o99A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa8 PUTATIVE LIPOPROTEIN
LPRF

(Mycobacterium
bovis) 		PF07161
(LppX_LprAFG) 		5 ALA A 106
ALA A  94
VAL A  92
LEU A 156
TYR A 150
 PJZ  A 301 (-3.3A)
PJZ  A 301 ( 4.0A)
None
None
PJZ  A 301 (-3.8A)
 1.27A 5eb5B-4qa8A:
undetectable		 5eb5B-4qa8A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 ALA K 163
ALA K 165
VAL K 193
LEU K   4
VAL K 175
 None
 1.36A 5eb5B-4qv9K:
undetectable		 5eb5B-4qv9K:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmp ALLOPHYCOCYANIN

(Phormidium
rubidum) 		PF00502
(Phycobilisome) 		5 ALA A 129
ALA A 125
VAL A  65
LEU A  82
VAL A  66
 CYC  A 201 ( 3.7A)
CYC  A 201 (-3.4A)
CYC  A 201 (-4.1A)
None
None
 1.44A 5eb5B-4rmpA:
undetectable		 5eb5B-4rmpA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 ARG A 177
ALA A 123
VAL A  95
HIS A  90
VAL A  94
 SAH  A 502 (-3.4A)
None
None
None
None
 1.18A 5eb5B-4rvhA:
undetectable		 5eb5B-4rvhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w82 FATTY ACID SYNTHASE

(Homo sapiens) 		PF00107
(ADH_zinc_N) 		5 ALA A1755
VAL A1744
LEU A1733
VAL A1741
HIS A1674
 None
 1.23A 5eb5B-4w82A:
undetectable		 5eb5B-4w82A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 5 ALA D  94
ALA D  97
VAL D 212
LEU D 125
VAL D 173
 None
 1.23A 5eb5B-4x28D:
undetectable		 5eb5B-4x28D:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x82 ZINC TRANSPORTER
ZIP4

(Pteropus alecto) 		no annotation 5 ALA B 288
ALA B 290
VAL B 199
LEU B 218
VAL B 202
 None
 1.13A 5eb5B-4x82B:
undetectable		 5eb5B-4x82B:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Pseudomonas
aeruginosa) 		PF06026
(Rib_5-P_isom_A) 		5 ALA A  44
ALA A  42
VAL A  15
LEU A  64
HIS A  46
 None
 1.46A 5eb5B-4x84A:
undetectable		 5eb5B-4x84A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A  41
ALA A 268
VAL A 212
LEU A 140
HIS A 216
 None
 1.17A 5eb5B-4xxnA:
undetectable		 5eb5B-4xxnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A  41
ALA A 268
VAL A 212
LEU A 140
HIS A 216
 None
 1.20A 5eb5B-4xy3A:
undetectable		 5eb5B-4xy3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ALA A 293
VAL A 290
LEU A 433
HIS A 446
VAL A 448
 None
 1.46A 5eb5B-4yhjA:
undetectable		 5eb5B-4yhjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A 463
ALA A 400
VAL A 434
LEU A 540
VAL A 432
 None
 1.45A 5eb5B-4zo6A:
undetectable		 5eb5B-4zo6A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 ALA A1275
ALA A1234
LEU A1302
VAL A1254
TYR A1294
 None
 1.26A 5eb5B-5a31A:
undetectable		 5eb5B-5a31A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Streptococcus
pneumoniae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A   4
ALA A 122
VAL A 136
LEU A 322
VAL A 164
 None
 1.47A 5eb5B-5bqsA:
undetectable		 5eb5B-5bqsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ALA A 293
ALA A 275
VAL A 303
VAL A 304
TYR A 468
 None
 0.88A 5eb5B-5cniA:
undetectable		 5eb5B-5cniA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 ALA B  91
ALA B  63
VAL B  81
LEU B 356
VAL B 417
 None
 1.10A 5eb5B-5e6sB:
undetectable		 5eb5B-5e6sB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 ALA A  45
ALA A  41
VAL A  39
LEU A 141
VAL A   4
 None
 1.43A 5eb5B-5e72A:
undetectable		 5eb5B-5e72A:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		10 ALA A 111
ARG A 301
ALA A 317
VAL A 329
LEU A 343
HIS A 358
VAL A 360
TYR A 458
TRP A 459
HIS A 498
 FAD  A 601 ( 3.2A)
None
010  A 609 ( 3.9A)
None
None
010  A 609 (-4.6A)
010  A 609 ( 4.8A)
010  A 609 (-4.5A)
FAD  A 601 ( 3.7A)
010  A 609 ( 4.0A)
 0.16A 5eb5B-5eb5A:
68.5		 5eb5B-5eb5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		6 ALA A 111
ARG A 301
LEU A 343
HIS A 358
VAL A 360
HIS A 460
 FAD  A 601 ( 3.2A)
None
None
010  A 609 (-4.6A)
010  A 609 ( 4.8A)
FAD  A 601 (-4.0A)
 1.44A 5eb5B-5eb5A:
68.5		 5eb5B-5eb5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsh CSM6

(Thermus
thermophilus) 		PF09670
(Cas_Cas02710) 		5 ALA A 129
ALA A  73
VAL A  76
HIS A 123
HIS A  55
 None
 1.46A 5eb5B-5fshA:
undetectable		 5eb5B-5fshA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		5 ALA A 612
ARG A 618
HIS A 520
TYR A 588
HIS A 586
 None
 1.47A 5eb5B-5hmqA:
undetectable		 5eb5B-5hmqA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		5 ALA A 616
VAL A 543
HIS A 517
VAL A 479
TYR A 619
 None
 0.99A 5eb5B-5jmdA:
undetectable		 5eb5B-5jmdA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A 145
ALA A 188
VAL A 238
LEU A 227
VAL A 234
 None
 1.17A 5eb5B-5ju6A:
undetectable		 5eb5B-5ju6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvc HALOHYDRIN
DEHALOGENASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		5 ALA A 225
VAL A  75
LEU A 217
VAL A  77
HIS A  26
 None
 1.19A 5eb5B-5kvcA:
3.0		 5eb5B-5kvcA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ALA A 293
ALA A 275
VAL A 303
VAL A 304
TYR A 468
 None
 0.97A 5eb5B-5kznA:
undetectable		 5eb5B-5kznA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00227
(Proteasome) 		5 ALA K 162
ALA K 164
VAL K 192
LEU K   4
VAL K 174
 None
 1.35A 5eb5B-5l5wK:
undetectable		 5eb5B-5l5wK:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 ALA A1275
ALA A1234
LEU A1302
VAL A1254
TYR A1294
 None
 1.28A 5eb5B-5lcwA:
undetectable		 5eb5B-5lcwA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A 987
ALA A 991
VAL A1151
LEU A1080
VAL A1133
 None
 1.48A 5eb5B-5lpyA:
undetectable		 5eb5B-5lpyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00227
(Proteasome) 		5 ALA K 162
ALA K 164
VAL K 192
LEU K   4
VAL K 174
 None
MG  K 302 (-4.8A)
None
None
None
 1.34A 5eb5B-5m2bK:
undetectable		 5eb5B-5m2bK:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 5 ALA A 122
ALA A 120
VAL A 265
LEU A 387
TRP A 386
 None
 1.28A 5eb5B-5oieA:
undetectable		 5eb5B-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		5 ALA A  47
ALA A  45
VAL A  34
LEU A 373
VAL A 229
 None
 1.35A 5eb5B-5uaoA:
8.6		 5eb5B-5uaoA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE

(Neurospora
crassa) 		no annotation 5 ALA C  88
ALA C  90
VAL C 100
LEU C 249
VAL C 257
 None
 1.22A 5eb5B-5v12C:
undetectable		 5eb5B-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US11

(Toxoplasma
gondii) 		PF00411
(Ribosomal_S11) 		5 ALA O  84
ALA O  82
VAL O  61
LEU O 129
VAL O  59
 None
 1.33A 5eb5B-5xxuO:
undetectable		 5eb5B-5xxuO:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 5 ALA A 204
ARG A 341
VAL A 344
LEU A 197
TYR A 240
 None
 1.08A 5eb5B-6bk5A:
undetectable		 5eb5B-6bk5A:
undetectable