SIMILAR PATTERNS OF AMINO ACIDS FOR 5EB5_A_010A609

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00977
(His_biosynth) 		5 ALA F  36
VAL F  18
LEU F  78
VAL F  13
HIS F 229
 None
 1.06A 5eb5A-1ka9F:
undetectable		 5eb5A-1ka9F:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prt PERTUSSIS TOXIN
(SUBUNIT S1)

(Bordetella
pertussis) 		PF02917
(Pertussis_S1) 		5 ALA A 124
ALA A 120
LEU A  36
LEU A 131
HIS A  35
 None
 1.14A 5eb5A-1prtA:
undetectable		 5eb5A-1prtA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q32 TYROSYL-DNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		5 ALA A 483
LEU A 185
LEU A 237
TYR A 244
HIS A 181
 None
 1.25A 5eb5A-1q32A:
undetectable		 5eb5A-1q32A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 ALA A  90
ALA A 114
LEU A 111
LEU A  14
VAL A 106
 None
 1.26A 5eb5A-1qvrA:
undetectable		 5eb5A-1qvrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		5 ALA A 229
ALA A 232
VAL A 166
LEU A 402
VAL A 271
 None
 1.27A 5eb5A-1r6vA:
0.0		 5eb5A-1r6vA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		5 ALA A  42
ALA A 252
VAL A 281
LEU A 277
LEU A 297
 None
 1.05A 5eb5A-1v19A:
0.0		 5eb5A-1v19A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6b HARMONIN ISOFORM A1

(Mus musculus) 		PF00595
(PDZ) 		5 ALA A  91
ALA A  87
LEU A  88
LEU A 101
VAL A  76
 None
 1.27A 5eb5A-1v6bA:
undetectable		 5eb5A-1v6bA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 ALA A 495
ALA A 491
LEU A 492
LEU A 445
HIS A 526
 None
 1.27A 5eb5A-1w07A:
undetectable		 5eb5A-1w07A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wly 2-HALOACRYLATE
REDUCTASE

(Burkholderia
sp. WS) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  69
ALA A  37
VAL A 328
HIS A 122
VAL A 302
 ALA  A  69 ( 0.0A)
ALA  A  37 ( 0.0A)
VAL  A 328 ( 0.6A)
HIS  A 122 ( 1.0A)
VAL  A 302 ( 0.6A)
 1.32A 5eb5A-1wlyA:
undetectable		 5eb5A-1wlyA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ALA A 123
ALA A 114
LEU A 120
LEU A  21
VAL A   6
 None
 1.27A 5eb5A-1zczA:
undetectable		 5eb5A-1zczA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 225
ALA A 221
VAL A 410
LEU A 189
VAL A 353
 None
 1.13A 5eb5A-1zk7A:
9.8		 5eb5A-1zk7A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ALA A 392
ALA A 388
LEU A 355
HIS A 352
VAL A 419
 None
 1.23A 5eb5A-2cxeA:
undetectable		 5eb5A-2cxeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 ALA A 235
ALA A 232
VAL A 225
LEU A 245
VAL A 194
 None
 1.27A 5eb5A-2d4eA:
undetectable		 5eb5A-2d4eA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 ALA A 191
ALA A 187
VAL A 368
LEU A 364
LEU A 350
 None
 1.27A 5eb5A-2fncA:
undetectable		 5eb5A-2fncA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		5 ALA A 224
ALA A 281
VAL A 263
LEU A 289
VAL A 257
 None
 1.29A 5eb5A-2fv0A:
undetectable		 5eb5A-2fv0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5g PUTATIVE LIPOPROTEIN

(Campylobacter
jejuni) 		PF04187
(Cofac_haem_bdg) 		5 ALA X 137
ALA X  78
VAL X 212
LEU X 214
VAL X  41
 None
 0.97A 5eb5A-2g5gX:
undetectable		 5eb5A-2g5gX:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 ALA A 191
ALA A 187
VAL A 368
LEU A 364
LEU A 350
 None
 1.24A 5eb5A-2ghbA:
undetectable		 5eb5A-2ghbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA

(Mycobacterium
tuberculosis) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		5 ALA A  88
ALA A  85
LEU A  74
LEU A 101
VAL A  77
 None
 1.13A 5eb5A-2h5xA:
undetectable		 5eb5A-2h5xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA

(Mycobacterium
tuberculosis) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		5 ALA A  88
ALA A  85
VAL A  80
LEU A  74
VAL A  77
 None
None
GOL  A 501 ( 4.8A)
None
None
 1.30A 5eb5A-2h5xA:
undetectable		 5eb5A-2h5xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		5 ALA A 306
ALA A 308
VAL A 127
LEU A 284
VAL A 143
 None
 1.26A 5eb5A-2iv0A:
undetectable		 5eb5A-2iv0A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mra DE NOVO DESIGNED
PROTEIN OR459

(synthetic
construct) 		no annotation 5 ALA A  41
ALA A  44
VAL A  56
LEU A  25
TRP A  76
 None
 1.08A 5eb5A-2mraA:
undetectable		 5eb5A-2mraA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		5 ALA A  75
ALA A  71
LEU A  72
LEU A  85
VAL A  65
 None
 1.09A 5eb5A-2p0oA:
undetectable		 5eb5A-2p0oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p26 INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin) 		5 ALA A  91
ALA A  63
VAL A  81
LEU A 356
VAL A 417
 None
 1.13A 5eb5A-2p26A:
undetectable		 5eb5A-2p26A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph7 UNCHARACTERIZED
PROTEIN AF_2093

(Archaeoglobus
fulgidus) 		no annotation 5 ALA A 191
ALA A 194
VAL A 160
LEU A 157
HIS A 156
 None
 1.21A 5eb5A-2ph7A:
undetectable		 5eb5A-2ph7A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		5 ALA A 123
ALA A 241
LEU A 136
LEU A 270
HIS A 288
 None
 1.33A 5eb5A-2punA:
undetectable		 5eb5A-2punA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 378
ALA A 375
VAL A 540
LEU A 383
VAL A 470
 None
 1.19A 5eb5A-2q27A:
undetectable		 5eb5A-2q27A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 224
ALA A 220
VAL A 416
LEU A 187
VAL A 359
 None
 1.15A 5eb5A-2qaeA:
11.7		 5eb5A-2qaeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		5 ALA A 124
VAL A  36
LEU A  34
LEU A 105
VAL A  83
 None
 1.30A 5eb5A-2qj8A:
undetectable		 5eb5A-2qj8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 ALA A 421
VAL A 404
LEU A 418
LEU A 280
VAL A 406
 None
 1.31A 5eb5A-2r66A:
1.8		 5eb5A-2r66A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 ALA A 349
ALA A 345
VAL A 311
LEU A 346
VAL A 313
 None
 1.11A 5eb5A-2yrrA:
undetectable		 5eb5A-2yrrA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2v 3'-5'-EXONUCLEASE

(Saccharomyces
cerevisiae) 		PF01026
(TatD_DNase) 		5 ALA A  79
VAL A  96
LEU A  45
LEU A  67
VAL A  99
 None
 1.30A 5eb5A-3e2vA:
undetectable		 5eb5A-3e2vA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		5 ALA A 194
ALA A 198
LEU A 134
LEU A 125
TRP A 191
 None
 1.26A 5eb5A-3e8sA:
undetectable		 5eb5A-3e8sA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		5 ALA A  76
ALA A  86
VAL A 117
LEU A 120
LEU A 107
 None
 0.97A 5eb5A-3exnA:
undetectable		 5eb5A-3exnA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		5 ALA A 179
ALA A 176
VAL A 171
LEU A 284
VAL A 327
 None
 1.27A 5eb5A-3fddA:
undetectable		 5eb5A-3fddA:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		6 ALA A 111
ARG A 300
HIS A 357
TYR A 457
TRP A 458
HIS A 497
 FAD  A 522 ( 3.0A)
None
HBX  A 530 (-4.5A)
HBX  A 530 (-4.3A)
FAD  A 522 (-3.9A)
HBX  A 530 ( 3.9A)
 0.35A 5eb5A-3gdnA:
64.6		 5eb5A-3gdnA:
74.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h86 ADENYLATE KINASE

(Methanococcus
maripaludis) 		no annotation 5 ALA B  74
ALA B  42
VAL B  37
LEU B 105
VAL B  89
 None
 1.22A 5eb5A-3h86B:
undetectable		 5eb5A-3h86B:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 ALA A 407
VAL A 348
LEU A 350
LEU A 294
VAL A 276
 None
 1.22A 5eb5A-3hbjA:
undetectable		 5eb5A-3hbjA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A 268
ALA A 257
VAL A 401
LEU A 404
LEU A 389
 None
 1.32A 5eb5A-3hz6A:
undetectable		 5eb5A-3hz6A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		5 ALA A 201
ALA A  74
VAL A  72
LEU A  69
LEU A  10
 None
 1.26A 5eb5A-3ka7A:
2.1		 5eb5A-3ka7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 ALA A1100
ALA A1137
LEU A1134
LEU A1125
HIS A1131
 None
 1.26A 5eb5A-3kg7A:
undetectable		 5eb5A-3kg7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1

(Saccharomyces
cerevisiae) 		PF01680
(SOR_SNZ) 		5 ALA A 254
ALA A 221
VAL A 232
LEU A 247
VAL A 234
 None
 1.08A 5eb5A-3o07A:
undetectable		 5eb5A-3o07A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 365
VAL A 381
LEU A 400
LEU A 370
VAL A 379
 None
 1.21A 5eb5A-3otrA:
undetectable		 5eb5A-3otrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ALA A  53
VAL A 371
LEU A 367
LEU A 339
VAL A 370
 None
 1.16A 5eb5A-3ppcA:
undetectable		 5eb5A-3ppcA:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		7 ALA A 111
ARG A 301
HIS A 358
VAL A 360
TYR A 458
TRP A 459
HIS A 498
 FAD  A 773 (-3.0A)
None
None
None
None
FAD  A 773 (-3.8A)
FAD  A 773 (-4.4A)
 0.34A 5eb5A-3redA:
64.0		 5eb5A-3redA:
76.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		5 ALA A 483
LEU A 185
LEU A 237
TYR A 244
HIS A 181
 None
 1.22A 5eb5A-3sq7A:
undetectable		 5eb5A-3sq7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ALA B 136
ALA B 132
LEU B 133
LEU B  47
VAL B 111
 None
 1.15A 5eb5A-3sqgB:
undetectable		 5eb5A-3sqgB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t69 PUTATIVE
2-DEHYDRO-3-DEOXYGAL
ACTONOKINASE

(Sinorhizobium
meliloti) 		PF05035
(DGOK) 		5 ALA A  10
ALA A  61
VAL A  59
LEU A  56
HIS A  55
 None
 1.21A 5eb5A-3t69A:
undetectable		 5eb5A-3t69A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		5 ALA A 637
ALA A 476
LEU A 550
HIS A 549
VAL A 553
 None
 1.32A 5eb5A-4aysA:
undetectable		 5eb5A-4aysA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		5 ALA B 160
ALA B 140
VAL B 123
LEU B 102
VAL B  88
 None
 1.06A 5eb5A-4ci2B:
undetectable		 5eb5A-4ci2B:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		5 ALA A 229
ARG A 257
ALA A 217
VAL A 242
VAL A 250
 None
 1.28A 5eb5A-4e3aA:
undetectable		 5eb5A-4e3aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E

(Linum
nodiflorum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 ALA A 347
LEU A 282
LEU A 270
VAL A 366
TRP A 340
 None
 1.28A 5eb5A-4eviA:
undetectable		 5eb5A-4eviA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Campylobacter
jejuni) 		PF00977
(His_biosynth) 		5 ALA A  71
VAL A  98
LEU A  70
LEU A  10
VAL A  80
 None
 1.18A 5eb5A-4gj1A:
undetectable		 5eb5A-4gj1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 5 ALA B 221
VAL B 101
LEU B 194
LEU B 118
VAL B 196
 None
 1.09A 5eb5A-4gt2B:
1.4		 5eb5A-4gt2B:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		5 ALA B 243
LEU B 240
LEU B 231
VAL B 219
HIS B 249
 None
 1.33A 5eb5A-4i6jB:
undetectable		 5eb5A-4i6jB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 ALA A 237
VAL A 252
LEU A 254
LEU A 266
VAL A 274
 None
 1.28A 5eb5A-4maaA:
undetectable		 5eb5A-4maaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ALA A 172
VAL A 197
LEU A 199
LEU A 212
VAL A 226
 None
 1.22A 5eb5A-4o5hA:
undetectable		 5eb5A-4o5hA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o94 TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		5 ALA A  52
VAL A  62
LEU A 248
VAL A  29
TRP A 245
 None
 1.22A 5eb5A-4o94A:
undetectable		 5eb5A-4o94A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohc OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
cenocepacia) 		PF00156
(Pribosyltran) 		5 ARG A 147
ALA A  79
VAL A 126
LEU A 128
VAL A 153
 None
 1.20A 5eb5A-4ohcA:
undetectable		 5eb5A-4ohcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohq TRIOSEPHOSPHATE
ISOMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00121
(TIM) 		5 ALA A  32
ALA A 243
VAL A 246
LEU A  56
VAL A  40
 None
 1.03A 5eb5A-4ohqA:
undetectable		 5eb5A-4ohqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6u UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 156
ALA A 154
LEU A 153
LEU A 140
TRP A 105
 None
None
None
None
1PE  A 401 (-3.6A)
 1.16A 5eb5A-4q6uA:
undetectable		 5eb5A-4q6uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 ARG A 177
ALA A 123
VAL A  95
HIS A  90
VAL A  94
 SAH  A 502 (-3.4A)
None
None
None
None
 1.26A 5eb5A-4rvhA:
undetectable		 5eb5A-4rvhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w82 FATTY ACID SYNTHASE

(Homo sapiens) 		PF00107
(ADH_zinc_N) 		5 ALA A1755
VAL A1744
LEU A1733
VAL A1741
HIS A1674
 None
 1.23A 5eb5A-4w82A:
undetectable		 5eb5A-4w82A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x82 ZINC TRANSPORTER
ZIP4

(Pteropus alecto) 		no annotation 5 ALA B 288
ALA B 290
VAL B 199
LEU B 218
VAL B 202
 None
 1.08A 5eb5A-4x82B:
undetectable		 5eb5A-4x82B:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN SEH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ALA C 117
ARG C 196
LEU C 183
LEU C 136
HIS C 120
 None
 1.23A 5eb5A-4xmmC:
undetectable		 5eb5A-4xmmC:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A  41
ALA A 268
VAL A 212
LEU A 140
HIS A 216
 None
 1.17A 5eb5A-4xxnA:
undetectable		 5eb5A-4xxnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)

(Mycobacterium
avium) 		PF00722
(Glyco_hydro_16) 		5 ALA A 265
ALA A 109
VAL A 250
LEU A 248
LEU A 139
 None
 1.16A 5eb5A-4xxpA:
undetectable		 5eb5A-4xxpA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A  41
ALA A 268
VAL A 212
LEU A 140
HIS A 216
 None
 1.19A 5eb5A-4xy3A:
undetectable		 5eb5A-4xy3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 5 VAL A 326
LEU A 226
LEU A 264
VAL A 323
TYR A 275
 None
 1.29A 5eb5A-4zuzA:
undetectable		 5eb5A-4zuzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz3 M64R

(Myxoma virus) 		PF03287
(Pox_C7_F8A) 		5 ALA A  99
ALA A  97
VAL A  93
LEU A  37
LEU A  13
 None
 1.12A 5eb5A-5cz3A:
undetectable		 5eb5A-5cz3A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 ARG A 435
ALA A 453
LEU A 454
LEU A 190
VAL A 432
 None
 1.32A 5eb5A-5dqfA:
undetectable		 5eb5A-5dqfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 ALA B  91
ALA B  63
VAL B  81
LEU B 356
VAL B 417
 None
 1.14A 5eb5A-5e6sB:
1.4		 5eb5A-5e6sB:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		11 ALA A 111
ARG A 301
ALA A 317
VAL A 329
LEU A 331
LEU A 343
HIS A 358
VAL A 360
TYR A 458
TRP A 459
HIS A 498
 FAD  A 601 ( 3.2A)
None
010  A 609 ( 3.9A)
None
010  A 609 ( 3.9A)
None
010  A 609 (-4.6A)
010  A 609 ( 4.8A)
010  A 609 (-4.5A)
FAD  A 601 ( 3.7A)
010  A 609 ( 4.0A)
 0.00A 5eb5A-5eb5A:
71.4		 5eb5A-5eb5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		6 ALA A 111
ARG A 301
LEU A 343
HIS A 358
VAL A 360
HIS A 460
 FAD  A 601 ( 3.2A)
None
None
010  A 609 (-4.6A)
010  A 609 ( 4.8A)
FAD  A 601 (-4.0A)
 1.41A 5eb5A-5eb5A:
71.4		 5eb5A-5eb5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 ALA A 306
ALA A 316
LEU A 191
LEU A 286
VAL A 325
 None
 1.31A 5eb5A-5ehkA:
undetectable		 5eb5A-5ehkA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ALA A 840
ALA A 832
LEU A 713
LEU A 847
HIS A 709
 None
 1.29A 5eb5A-5enoA:
2.7		 5eb5A-5enoA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep0 PUTATIVE REPRESSOR
PROTEIN LUXO

(Photobacterium
angustum) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 ALA A 229
ALA A 233
LEU A 238
LEU A 254
TYR A 263
 None
 1.21A 5eb5A-5ep0A:
undetectable		 5eb5A-5ep0A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO

(Photobacterium
angustum) 		PF00158
(Sigma54_activat) 		5 ALA A 229
ALA A 233
LEU A 238
LEU A 254
TYR A 263
 None
 1.28A 5eb5A-5ep1A:
undetectable		 5eb5A-5ep1A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF12341
(Mcl1_mid) 		5 ALA A 546
ALA A 548
VAL A 573
LEU A 554
LEU A 604
 None
 1.07A 5eb5A-5gvbA:
undetectable		 5eb5A-5gvbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 ALA B 603
LEU B 602
LEU B 571
TYR B 146
HIS B 129
 None
 1.24A 5eb5A-5hccB:
undetectable		 5eb5A-5hccB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		5 ALA A 215
ALA A 211
VAL A 138
LEU A 212
LEU A   3
 None
 1.15A 5eb5A-5hj5A:
undetectable		 5eb5A-5hj5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 5 ALA Z 159
ALA Z 139
VAL Z 122
LEU Z 101
VAL Z  87
 None
 1.21A 5eb5A-5hxbZ:
undetectable		 5eb5A-5hxbZ:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isu LMO0135 PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		5 ALA A 304
ALA A 300
VAL A 353
LEU A 301
LEU A 393
 None
 1.26A 5eb5A-5isuA:
undetectable		 5eb5A-5isuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		5 ALA A 616
VAL A 543
HIS A 517
VAL A 479
TYR A 619
 None
 0.95A 5eb5A-5jmdA:
undetectable		 5eb5A-5jmdA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP3

(Rhinovirus C) 		PF00073
(Rhv) 		5 ALA B 209
VAL B 130
LEU B  82
LEU B  92
VAL B 188
 None
 0.98A 5eb5A-5k0uB:
undetectable		 5eb5A-5k0uB:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvc HALOHYDRIN
DEHALOGENASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		5 ALA A 225
VAL A  75
LEU A 217
VAL A  77
HIS A  26
 None
 1.18A 5eb5A-5kvcA:
2.9		 5eb5A-5kvcA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 ALA A1275
ALA A1234
LEU A1302
VAL A1254
TYR A1294
 None
 1.32A 5eb5A-5lcwA:
undetectable		 5eb5A-5lcwA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		5 ALA A 221
VAL A 101
LEU A 194
LEU A 118
VAL A 196
 None
 1.08A 5eb5A-5mapA:
undetectable		 5eb5A-5mapA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA

(Methanothermococcus
thermolithotrophicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ALA B 141
ALA B 137
LEU B 138
LEU B  50
VAL B 114
 None
 1.22A 5eb5A-5n1qB:
undetectable		 5eb5A-5n1qB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ALA B 141
ALA B 137
LEU B 138
LEU B  50
VAL B 114
 None
 1.24A 5eb5A-5n28B:
undetectable		 5eb5A-5n28B:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 5 ALA A 546
ALA A 548
VAL A 573
LEU A 554
LEU A 604
 None
 1.04A 5eb5A-5ogsA:
undetectable		 5eb5A-5ogsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 5 ALA A 122
ALA A 120
VAL A 265
LEU A 387
TRP A 386
 None
 1.26A 5eb5A-5oieA:
undetectable		 5eb5A-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE

(Neurospora
crassa) 		no annotation 5 ALA C  88
ALA C  90
VAL C 100
LEU C 249
VAL C 257
 None
 1.15A 5eb5A-5v12C:
undetectable		 5eb5A-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyk CHIMERA PROTEIN OF
BRS DOMAIN OF BRAF
AND CC-SAM DOMAIN OF
KSR1,SERINE/THREONIN
E-PROTEIN KINASE
B-RAF

(Homo sapiens) 		no annotation 5 ALA A 152
VAL A 122
LEU A 147
LEU A 135
TRP A 112
 None
 1.11A 5eb5A-5vykA:
undetectable		 5eb5A-5vykA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wso NS3 HELICASE

(Pestivirus A) 		no annotation 5 ALA A 415
VAL A 449
LEU A 418
LEU A 385
VAL A 403
 None
 1.26A 5eb5A-5wsoA:
undetectable		 5eb5A-5wsoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		5 ALA A 415
VAL A 449
LEU A 418
LEU A 385
VAL A 403
 None
 1.26A 5eb5A-5wx1A:
undetectable		 5eb5A-5wx1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US11

(Toxoplasma
gondii) 		PF00411
(Ribosomal_S11) 		5 ALA O  84
ALA O  82
VAL O  61
LEU O 129
VAL O  59
 None
 1.32A 5eb5A-5xxuO:
undetectable		 5eb5A-5xxuO:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 5 ALA A 541
ALA A 579
LEU A 573
LEU A 509
VAL A 603
 None
 1.20A 5eb5A-5yfbA:
undetectable		 5eb5A-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 5 ALA A 204
ARG A 341
VAL A 344
LEU A 197
TYR A 240
 None
 1.11A 5eb5A-6bk5A:
undetectable		 5eb5A-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 5 ALA A 155
ALA A 181
VAL A 199
LEU A 184
LEU A  70
 None
 1.19A 5eb5A-6c43A:
undetectable		 5eb5A-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 ALA A1025
ALA A1071
VAL A1056
LEU A1058
VAL A1044
 None
 1.09A 5eb5A-6en4A:
undetectable		 5eb5A-6en4A:
undetectable