SIMILAR PATTERNS OF AMINO ACIDS FOR 5E8Q_A_FOLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cz3 DIHYDROFOLATE
REDUCTASE

(Thermotoga
maritima) 		PF00186
(DHFR_1) 		3 ASP A  27
LEU A  55
ARG A  58
 None
 0.32A 5e8qA-1cz3A:
19.5		 5e8qA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		3 ASP M 380
LEU M 200
ARG M 194
 None
None
SO4  M 931 (-3.4A)
 0.96A 5e8qA-1dwaM:
undetectable		 5e8qA-1dwaM:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		3 ASP A 146
LEU A  53
ARG A  63
 None
 0.96A 5e8qA-1eg3A:
undetectable		 5e8qA-1eg3A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		3 ASP A 257
LEU A 114
ARG A 126
 None
 0.53A 5e8qA-1fpsA:
undetectable		 5e8qA-1fpsA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASP A  56
LEU A 730
ARG A 718
 None
 0.61A 5e8qA-1hwwA:
undetectable		 5e8qA-1hwwA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		3 ASP A  67
LEU A  23
ARG A  20
 None
 0.96A 5e8qA-1jqeA:
undetectable		 5e8qA-1jqeA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juv DIHYDROFOLATE
REDUCTASE

(Escherichia
virus T4) 		PF00186
(DHFR_1) 		3 ASP A  36
LEU A  63
ARG A  66
 None
 0.86A 5e8qA-1juvA:
17.2		 5e8qA-1juvA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzj HYPOTHETICAL PROTEIN
YADB

(Escherichia
coli) 		PF00749
(tRNA-synt_1c) 		3 ASP A 167
LEU A  89
ARG A  86
 None
 0.90A 5e8qA-1nzjA:
undetectable		 5e8qA-1nzjA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		3 ASP A   2
LEU A 261
ARG A 258
 None
 0.76A 5e8qA-1q5mA:
undetectable		 5e8qA-1q5mA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		3 ASP A  89
LEU A 182
ARG A 179
 None
FON  A 330 ( 4.5A)
FON  A 330 (-3.7A)
 0.60A 5e8qA-1qd1A:
undetectable		 5e8qA-1qd1A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		3 ASP A 218
LEU A  79
ARG A  93
 None
 0.63A 5e8qA-1rtrA:
undetectable		 5e8qA-1rtrA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 ASP A 332
LEU A  21
ARG A 395
 None
 0.90A 5e8qA-1s1fA:
undetectable		 5e8qA-1s1fA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		3 ASP A 218
LEU A  83
ARG A  95
 None
 0.71A 5e8qA-1wy0A:
undetectable		 5e8qA-1wy0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A

(Homo sapiens) 		PF00782
(DSPc) 		3 ASP A  57
LEU A  14
ARG A 122
 SO4  A 211 ( 4.2A)
None
None
 0.84A 5e8qA-1yz4A:
undetectable		 5e8qA-1yz4A:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		3 ASP A  27
LEU A  54
ARG A  57
 None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.59A 5e8qA-1zdrA:
24.1		 5e8qA-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		3 ASP A  70
LEU A  40
ARG A  60
 None
 0.96A 5e8qA-2a7sA:
undetectable		 5e8qA-2a7sA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
vivax) 		PF00186
(DHFR_1) 		3 ASP A  53
LEU A 128
ARG A 131
 CP7  A1240 (-3.1A)
MES  A1241 (-4.5A)
MES  A1241 (-2.7A)
 0.41A 5e8qA-2blbA:
19.3		 5e8qA-2blbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 3 ASP P 275
LEU P  55
ARG P  58
 None
 0.75A 5e8qA-2btvP:
undetectable		 5e8qA-2btvP:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		3 ASP A 312
LEU A 274
ARG A 277
 None
 0.95A 5e8qA-2e3zA:
undetectable		 5e8qA-2e3zA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 ASP A   2
LEU A 261
ARG A 258
 None
 0.82A 5e8qA-2fvlA:
undetectable		 5e8qA-2fvlA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 ASP A  48
LEU A  91
ARG A  94
 None
 0.41A 5e8qA-2h2qA:
19.0		 5e8qA-2h2qA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 ASP A  32
LEU A  67
ARG A  70
 MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
 0.47A 5e8qA-2oipA:
20.0		 5e8qA-2oipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 301
LEU A  57
ARG A  83
 None
LGT  A 501 ( 4.5A)
LGT  A 501 (-3.3A)
 0.90A 5e8qA-2pp3A:
undetectable		 5e8qA-2pp3A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
anthracis) 		PF02540
(NAD_synthase) 		3 ASP A 159
LEU A 225
ARG A 252
 None
 0.92A 5e8qA-2pz8A:
undetectable		 5e8qA-2pz8A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q05 DUAL SPECIFICITY
PROTEIN PHOSPHATASE

(Vaccinia virus) 		PF00782
(DSPc) 		3 ASP A  79
LEU A  36
ARG A 149
 None
 0.87A 5e8qA-2q05A:
undetectable		 5e8qA-2q05A:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		3 ASP A  31
LEU A  61
ARG A  64
 VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
 0.70A 5e8qA-2w3wA:
23.5		 5e8qA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		3 ASP A  27
LEU A  54
ARG A  57
 TOP  A1160 (-2.8A)
None
None
 0.52A 5e8qA-2w9sA:
24.3		 5e8qA-2w9sA:
38.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA

(Homo sapiens) 		PF01602
(Adaptin_N) 		3 ASP B 158
LEU B 197
ARG B 166
 None
 0.78A 5e8qA-2xa7B:
undetectable		 5e8qA-2xa7B:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 ASP A 128
LEU A 195
ARG A 189
 None
 0.94A 5e8qA-2zxhA:
undetectable		 5e8qA-2zxhA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		3 ASP A 234
LEU A 104
ARG A 116
 None
None
FPP  A1002 (-2.9A)
 0.54A 5e8qA-3aq0A:
undetectable		 5e8qA-3aq0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		3 ASP A 232
LEU A  91
ARG A 143
 None
 0.94A 5e8qA-3c7kA:
undetectable		 5e8qA-3c7kA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		3 ASP A 152
LEU A  48
ARG A  46
 SO4  A 346 (-3.3A)
None
None
 0.95A 5e8qA-3cerA:
undetectable		 5e8qA-3cerA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfr DIHYDROFOLATE
REDUCTASE

(Lactobacillus
casei) 		PF00186
(DHFR_1) 		3 ASP A  26
LEU A  54
ARG A  57
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.38A 5e8qA-3dfrA:
22.9		 5e8qA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		3 ASP A  54
LEU A 119
ARG A 122
 RJ6  A 609 (-3.0A)
RJ6  A 609 (-4.4A)
None
 0.33A 5e8qA-3dg8A:
19.6		 5e8qA-3dg8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 ASP A 489
LEU A 319
ARG A 315
 None
 0.96A 5e8qA-3egwA:
undetectable		 5e8qA-3egwA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASP A 266
LEU B1190
ARG A 341
 None
 0.85A 5e8qA-3h0gA:
undetectable		 5e8qA-3h0gA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE

(Homo sapiens) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 ASP A 122
LEU A  83
ARG A  95
 None
None
FMN  A 390 (-3.5A)
 0.78A 5e8qA-3hy8A:
undetectable		 5e8qA-3hy8A:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		3 ASP X  27
LEU X  54
ARG X  57
 N22  X 219 (-2.8A)
None
None
 0.57A 5e8qA-3i8aX:
24.3		 5e8qA-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		3 ASP A  56
LEU A 107
ARG A 104
 None
 0.61A 5e8qA-3iauA:
undetectable		 5e8qA-3iauA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ASP A 165
LEU A  24
ARG A  28
 None
 0.94A 5e8qA-3k6jA:
undetectable		 5e8qA-3k6jA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 ASP A  37
LEU A  80
ARG A  83
 None
 0.47A 5e8qA-3kjrA:
20.2		 5e8qA-3kjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		3 ASP A 220
LEU A  90
ARG A 102
 None
 0.49A 5e8qA-3mzvA:
undetectable		 5e8qA-3mzvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		3 ASP A 213
LEU A  75
ARG A  89
 None
 0.64A 5e8qA-3npkA:
undetectable		 5e8qA-3npkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		3 ASP A 222
LEU A  80
ARG A  94
 None
None
DMA  A 300 (-2.9A)
 0.57A 5e8qA-3p41A:
undetectable		 5e8qA-3p41A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		3 ASP A 217
LEU A  79
ARG A  93
 None
 0.47A 5e8qA-3p8lA:
undetectable		 5e8qA-3p8lA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
brucei) 		PF00186
(DHFR_1) 		3 ASP A  54
LEU A  97
ARG A 100
 WRA  A 602 (-2.9A)
None
None
 0.43A 5e8qA-3rg9A:
19.0		 5e8qA-3rg9A:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv0 K. POLYSPORUS DCR1

(Vanderwaltozyma
polyspora) 		PF00636
(Ribonuclease_3) 		3 ASP A 103
LEU A 230
ARG A 234
 None
 0.95A 5e8qA-3rv0A:
undetectable		 5e8qA-3rv0A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv1 K. POLYSPORUS DCR1

(Vanderwaltozyma
polyspora) 		PF00636
(Ribonuclease_3) 		3 ASP A 103
LEU A 230
ARG A 234
 None
 0.94A 5e8qA-3rv1A:
undetectable		 5e8qA-3rv1A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgw V-TYPE ATP SYNTHASE
BETA CHAIN

(Methanosarcina
mazei) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 ASP A 445
LEU A 426
ARG A 361
 None
 0.96A 5e8qA-3tgwA:
undetectable		 5e8qA-3tgwA:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		3 ASP A  28
LEU A  55
ARG A  58
 MTX  A2001 (-2.7A)
MTX  A2001 ( 4.5A)
MTX  A2001 (-2.8A)
 0.37A 5e8qA-3tq9A:
24.0		 5e8qA-3tq9A:
43.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		3 ASP A 227
LEU A  85
ARG A  99
 None
 0.60A 5e8qA-3ts7A:
undetectable		 5e8qA-3ts7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A
ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
PF12705
(PDDEXK_1) 		3 ASP A 786
LEU B 732
ARG B 735
 None
 0.72A 5e8qA-3u44A:
undetectable		 5e8qA-3u44A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 ASP A  54
LEU A 119
ARG A 122
 1CY  A 609 (-2.9A)
None
None
 0.43A 5e8qA-3um6A:
19.6		 5e8qA-3um6A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 ASP A 830
LEU A 714
ARG A 700
 None
 0.85A 5e8qA-3ummA:
undetectable		 5e8qA-3ummA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE

(Schistosoma
mansoni) 		PF00186
(DHFR_1) 		3 ASP A  28
LEU A  64
ARG A  67
 None
 0.31A 5e8qA-3vcoA:
18.9		 5e8qA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ASP A 724
LEU A 161
ARG A 407
 None
 0.91A 5e8qA-3viuA:
undetectable		 5e8qA-3viuA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkw REPLICASE LARGE
SUBUNIT

(Tobacco mosaic
virus) 		PF01443
(Viral_helicase1) 		3 ASP A 886
LEU A 676
ARG A 810
 None
SO4  A1207 (-4.4A)
SO4  A1207 (-3.9A)
 0.82A 5e8qA-3vkwA:
undetectable		 5e8qA-3vkwA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 ASP A 497
LEU A 259
ARG A 256
 None
 0.78A 5e8qA-3w6qA:
undetectable		 5e8qA-3w6qA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		3 ASP A 222
LEU A  80
ARG A  94
 None
None
GPP  A1297 (-3.0A)
 0.40A 5e8qA-3zouA:
undetectable		 5e8qA-3zouA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		3 ASP A 193
LEU A 424
ARG A 427
 None
 0.87A 5e8qA-4a5aA:
undetectable		 5e8qA-4a5aA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 ASP A 586
LEU A 171
ARG A 174
 None
 0.89A 5e8qA-4ah6A:
undetectable		 5e8qA-4ah6A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 ASP A1411
LEU A1405
ARG A1543
 None
 0.92A 5e8qA-4bedA:
undetectable		 5e8qA-4bedA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 ASP X 232
LEU X 173
ARG X 191
 None
 0.86A 5e8qA-4crmX:
undetectable		 5e8qA-4crmX:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpg LYSINE--TRNA LIGASE

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ASP A 238
LEU A 213
ARG A 178
 None
 0.74A 5e8qA-4dpgA:
undetectable		 5e8qA-4dpgA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING

(Polaromonas sp.
JS666) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ASP A  36
LEU A  30
ARG A  25
 None
 0.96A 5e8qA-4g2nA:
2.8		 5e8qA-4g2nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ASP A  20
LEU A 278
ARG A 387
 None
 0.87A 5e8qA-4ictA:
undetectable		 5e8qA-4ictA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8

(Homo sapiens) 		PF00782
(DSPc) 		3 ASP A 215
LEU A 170
ARG A 280
 SO4  A 501 (-3.6A)
None
None
 0.96A 5e8qA-4jmkA:
undetectable		 5e8qA-4jmkA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		3 ASP A 236
LEU A  94
ARG A 106
 None
 0.66A 5e8qA-4kk2A:
undetectable		 5e8qA-4kk2A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		3 ASP A  44
LEU A 333
ARG A 328
 GAL  A 600 (-3.2A)
None
None
 0.89A 5e8qA-4kzkA:
undetectable		 5e8qA-4kzkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		3 ASP A 246
LEU A 339
ARG A 286
 None
 0.63A 5e8qA-4lisA:
undetectable		 5e8qA-4lisA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 ASP A  64
LEU A 141
ARG A  57
 None
 0.91A 5e8qA-4lxlA:
undetectable		 5e8qA-4lxlA:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m2x DIHYDROFOLATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF00186
(DHFR_1) 		3 ASP A  27
LEU A  57
ARG A  60
 TMQ  A 202 ( 2.7A)
None
None
 0.43A 5e8qA-4m2xA:
22.0		 5e8qA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7v DIHYDROFOLATE
REDUCTASE

(Enterococcus
faecalis) 		PF00186
(DHFR_1) 		3 ASP A  27
LEU A  55
ARG A  58
 RAR  A 200 (-2.6A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.58A 5e8qA-4m7vA:
23.2		 5e8qA-4m7vA:
37.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A 625
LEU A 389
ARG A 145
 SO4  A 711 ( 4.8A)
None
None
 0.92A 5e8qA-4nreA:
undetectable		 5e8qA-4nreA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		3 ASP A 642
LEU A  31
ARG A 627
 None
 0.86A 5e8qA-4qlbA:
undetectable		 5e8qA-4qlbA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		3 ASP A 392
LEU A 430
ARG A 426
 None
 0.81A 5e8qA-4qwwA:
undetectable		 5e8qA-4qwwA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyi HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		3 ASP A  99
LEU A 138
ARG A 134
 MG  A 201 (-2.5A)
None
None
 0.83A 5e8qA-4qyiA:
undetectable		 5e8qA-4qyiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 3 ASP B 514
LEU B 527
ARG B 520
 None
 0.92A 5e8qA-4tqoB:
undetectable		 5e8qA-4tqoB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uou FUCOSE-SPECIFIC
LECTIN FLEA

(Aspergillus
fumigatus) 		PF07938
(Fungal_lectin) 		3 ASP A 193
LEU A 152
ARG A 190
 None
 0.86A 5e8qA-4uouA:
undetectable		 5e8qA-4uouA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASP A 647
LEU A 637
ARG A 682
 None
 0.76A 5e8qA-4w8jA:
undetectable		 5e8qA-4w8jA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASP A1169
LEU A 921
ARG A 976
 CA  A1204 (-3.6A)
None
None
 0.95A 5e8qA-4w8jA:
undetectable		 5e8qA-4w8jA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyk NUCLEAR RNA EXPORT
FACTOR 1

(Homo sapiens) 		PF02136
(NTF2) 		3 ASP A 399
LEU A 534
ARG A 515
 None
 0.88A 5e8qA-4wykA:
undetectable		 5e8qA-4wykA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		3 ASP A 637
LEU A 482
ARG A 479
 None
 0.90A 5e8qA-4zdaA:
undetectable		 5e8qA-4zdaA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		3 ASP A 233
LEU A  88
ARG A 102
 None
 0.84A 5e8qA-5e8lA:
undetectable		 5e8qA-5e8lA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo7 PREDICTED PROTEIN

(Aspergillus
oryzae) 		PF07938
(Fungal_lectin) 		3 ASP A 193
LEU A 152
ARG A 190
 None
 0.85A 5e8qA-5eo7A:
undetectable		 5e8qA-5eo7A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TATA-BOX-BINDING
PROTEIN

(Homo sapiens;
Homo sapiens) 		PF03153
(TFIIA)
PF00352
(TBP) 		3 ASP N 322
LEU P 244
ARG P 186
 None
 0.87A 5e8qA-5iy7N:
undetectable		 5e8qA-5iy7N:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 3 ASP A  61
LEU A 281
ARG A 288
 None
 0.81A 5e8qA-5mz9A:
undetectable		 5e8qA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncr TYROSINE PHOSPHATASE

(Orf virus) 		PF00782
(DSPc) 		3 ASP A  81
LEU A  37
ARG A 158
 PO4  A 200 (-3.8A)
None
None
 0.85A 5e8qA-5ncrA:
undetectable		 5e8qA-5ncrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofq CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		3 ASP A 260
LEU A 369
ARG A 268
 1PE  A 502 ( 3.9A)
None
None
 0.77A 5e8qA-5ofqA:
undetectable		 5e8qA-5ofqA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 ASP A  31
LEU A  94
ARG A  97
 73X  A 704 (-2.8A)
None
None
 0.35A 5e8qA-5t0lA:
20.2		 5e8qA-5t0lA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9x GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 3 ASP A 212
LEU A 313
ARG A 308
 None
 0.95A 5e8qA-5t9xA:
undetectable		 5e8qA-5t9xA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 3 ASP A 391
LEU A 173
ARG A 298
 None
 0.91A 5e8qA-5ww1A:
undetectable		 5e8qA-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 3 ASP A 176
LEU A 133
ARG A 137
 None
 0.76A 5e8qA-5xhxA:
undetectable		 5e8qA-5xhxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Homo sapiens;
Bos taurus) 		PF00010
(HLH)
PF00989
(PAS)
PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		3 ASP A 161
LEU A  68
ARG B 101
 None
 0.84A 5e8qA-5y7yA:
undetectable		 5e8qA-5y7yA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii) 		no annotation 3 ASP A 384
LEU A 438
ARG A 364
 None
 0.93A 5e8qA-5z0yA:
2.2		 5e8qA-5z0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9r HYDROXYETHYLPHOSPHON
ATE DIOXYGENASE

(Streptomyces
albus) 		no annotation 3 ASP A  38
LEU A 448
ARG A  22
 None
 0.94A 5e8qA-6b9rA:
undetectable		 5e8qA-6b9rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 3 ASP A 465
LEU A 478
ARG A 480
 None
 0.50A 5e8qA-6bo6A:
undetectable		 5e8qA-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 3 ASP A  28
LEU A  58
ARG A  61
 MMV  A 202 (-2.9A)
MMV  A 202 (-4.2A)
MMV  A 202 (-2.8A)
 0.51A 5e8qA-6cxmA:
20.5		 5e8qA-6cxmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e4e -

(-) 		no annotation 3 ASP A  27
LEU A  54
ARG A  57
 MMV  A 202 (-2.9A)
None
None
 0.51A 5e8qA-6e4eA:
24.3		 5e8qA-6e4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 362
LEU A 271
ARG A 279
 None
 0.89A 5e8qA-6emkA:
undetectable		 5e8qA-6emkA:
undetectable