SIMILAR PATTERNS OF AMINO ACIDS FOR 5E5J_A_017A201_3

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus) 		PF00191
(Annexin) 		3 ASP A 138
VAL A  94
LEU A 108
 None
 0.68A 5e5jB-1aowA:
undetectable		 5e5jB-1aowA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		3 ASP A 188
VAL A 238
LEU A 229
 None
 0.49A 5e5jB-1bf6A:
undetectable		 5e5jB-1bf6A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 178
VAL A 197
LEU A 215
 None
 0.68A 5e5jB-1bkhA:
0.0		 5e5jB-1bkhA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsz PROTEIN (PEPTIDE
DEFORMYLASE)

(Escherichia
coli) 		PF01327
(Pep_deformylase) 		3 ASP A  33
VAL A  51
LEU A  46
 None
 0.64A 5e5jB-1bszA:
0.0		 5e5jB-1bszA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ASP A 261
VAL A 312
LEU A 254
 None
 0.68A 5e5jB-1eu1A:
1.6		 5e5jB-1eu1A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		3 ASP A 321
VAL A  51
LEU A 343
 None
 0.60A 5e5jB-1f26A:
0.0		 5e5jB-1f26A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		3 ASP A  63
VAL A  74
LEU A 123
 None
 0.66A 5e5jB-1hcuA:
0.0		 5e5jB-1hcuA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASP A 472
VAL A 166
LEU A 467
 SWA  A1103 (-2.9A)
None
None
 0.64A 5e5jB-1hwwA:
0.0		 5e5jB-1hwwA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iaw TYPE II RESTRICTION
ENZYME NAEI

(Lechevalieria
aerocolonigenes) 		PF09126
(NaeI) 		3 ASP A  26
VAL A  35
LEU A  73
 None
 0.66A 5e5jB-1iawA:
0.0		 5e5jB-1iawA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1v CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Escherichia
coli) 		PF08299
(Bac_DnaA_C) 		3 ASP A 457
VAL A 383
LEU A 413
 None
 0.50A 5e5jB-1j1vA:
undetectable		 5e5jB-1j1vA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		3 ASP A 805
VAL A 811
LEU A 716
 None
 0.62A 5e5jB-1jqoA:
0.0		 5e5jB-1jqoA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lry PEPTIDE DEFORMYLASE

(Pseudomonas
aeruginosa) 		PF01327
(Pep_deformylase) 		3 ASP A  33
VAL A  51
LEU A  46
 None
 0.61A 5e5jB-1lryA:
undetectable		 5e5jB-1lryA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		3 ASP A 247
VAL A 267
LEU A 265
 None
 0.65A 5e5jB-1mxfA:
undetectable		 5e5jB-1mxfA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n2o PANTOTHENATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF02569
(Pantoate_ligase) 		3 ASP A 174
VAL A 118
LEU A 144
 None
 0.64A 5e5jB-1n2oA:
undetectable		 5e5jB-1n2oA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlx POLLEN ALLERGEN PHL
P 6

(Phleum pratense) 		PF01620
(Pollen_allerg_2) 		3 ASP A 452
VAL A 415
LEU A 464
 None
 0.67A 5e5jB-1nlxA:
undetectable		 5e5jB-1nlxA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1plg IGG2A=KAPPA=

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP H 211
VAL H 146
LEU H 156
 None
 0.60A 5e5jB-1plgH:
undetectable		 5e5jB-1plgH:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		3 ASP A 336
VAL A  58
LEU A 356
 None
 0.61A 5e5jB-1q5dA:
undetectable		 5e5jB-1q5dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv9 F420-DEPENDENT
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE

(Methanopyrus
kandleri) 		PF01993
(MTD) 		3 ASP A 122
VAL A 147
LEU A 207
 None
 0.56A 5e5jB-1qv9A:
undetectable		 5e5jB-1qv9A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzu HYPOTHETICAL PROTEIN
MDS018

(Homo sapiens) 		PF02441
(Flavoprotein) 		3 ASP A  74
VAL A  51
LEU A  91
 None
 0.62A 5e5jB-1qzuA:
undetectable		 5e5jB-1qzuA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r82 GLYCOPROTEIN-FUCOSYL
GALACTOSIDE
ALPHA-GALACTOSYLTRAN
SFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		3 ASP A 262
VAL A 318
LEU A 232
 None
 0.59A 5e5jB-1r82A:
undetectable		 5e5jB-1r82A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri6 PUTATIVE ISOMERASE
YBHE

(Escherichia
coli) 		PF10282
(Lactonase) 		3 ASP A 285
VAL A 303
LEU A  28
 None
 0.62A 5e5jB-1ri6A:
undetectable		 5e5jB-1ri6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 ASP A  31
VAL A  48
LEU A  38
 None
 0.51A 5e5jB-1tufA:
undetectable		 5e5jB-1tufA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 ASP C 774
VAL C 763
LEU C 806
 None
 0.58A 5e5jB-1u6gC:
undetectable		 5e5jB-1u6gC:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		3 ASP A 222
VAL A 188
LEU A 248
 None
 0.62A 5e5jB-1v5bA:
undetectable		 5e5jB-1v5bA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		3 ASP A 128
VAL A 126
LEU A  45
 None
 0.58A 5e5jB-1vchA:
undetectable		 5e5jB-1vchA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd5 HYPOTHETICAL PROTEIN
TT1426

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		3 ASP A 128
VAL A 126
LEU A  13
 None
 0.61A 5e5jB-1wd5A:
undetectable		 5e5jB-1wd5A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ASP A 243
VAL A 250
LEU A 224
 ASP  A 243 (-0.6A)
VAL  A 250 ( 0.6A)
LEU  A 224 ( 0.6A)
 0.66A 5e5jB-1wqaA:
undetectable		 5e5jB-1wqaA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws0 PEPTIDE DEFORMYLASE
1

(Bacillus cereus) 		PF01327
(Pep_deformylase) 		3 ASP A  34
VAL A  52
LEU A  47
 None
 0.65A 5e5jB-1ws0A:
1.2		 5e5jB-1ws0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvl DNA-BINDING PROTEINS
7A/7B/7D, GCN4

(Sulfolobus
acidocaldarius) 		PF02294
(7kD_DNA_binding) 		3 ASP A  49
VAL A  30
LEU A  54
 None
 0.62A 5e5jB-1wvlA:
undetectable		 5e5jB-1wvlA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		3 ASP A 297
VAL A 165
LEU A 327
 None
 0.32A 5e5jB-1x9jA:
undetectable		 5e5jB-1x9jA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		3 ASP A 270
VAL A 298
LEU A 264
 None
 0.54A 5e5jB-2a4mA:
undetectable		 5e5jB-2a4mA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Homo sapiens) 		PF16770
(RTT107_BRCT_5) 		3 ASP A1902
VAL A1909
LEU A1916
 None
 0.64A 5e5jB-2adoA:
undetectable		 5e5jB-2adoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0o UPLC1

(Homo sapiens) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		3 ASP E 572
VAL E 589
LEU E 551
 None
 0.66A 5e5jB-2b0oE:
undetectable		 5e5jB-2b0oE:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b67 COG0778:
NITROREDUCTASE

(Streptococcus
pneumoniae) 		PF00881
(Nitroreductase) 		3 ASP A 157
VAL A 164
LEU A  57
 None
 0.53A 5e5jB-2b67A:
undetectable		 5e5jB-2b67A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 ASP A  22
VAL A 563
LEU A  15
 None
 0.60A 5e5jB-2bklA:
undetectable		 5e5jB-2bklA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		3 ASP A 306
VAL A 222
LEU A 265
 None
 0.56A 5e5jB-2c1cA:
undetectable		 5e5jB-2c1cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 ASP A 138
VAL A 165
LEU A 181
 None
 0.59A 5e5jB-2cfzA:
undetectable		 5e5jB-2cfzA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 ASP A 327
VAL A  63
LEU A 347
 None
 0.54A 5e5jB-2dkkA:
undetectable		 5e5jB-2dkkA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 ASP A 236
VAL A 313
LEU A 309
 None
 0.67A 5e5jB-2e9fA:
undetectable		 5e5jB-2e9fA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6n BROMODOMAIN PHD
FINGER TRANSCRIPTION
FACTOR

(Homo sapiens) 		PF00439
(Bromodomain)
PF00628
(PHD) 		3 ASP A 136
VAL A 122
LEU A  81
 None
 0.60A 5e5jB-2f6nA:
undetectable		 5e5jB-2f6nA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		3 ASP A 134
VAL A 232
LEU A 160
 None
 0.66A 5e5jB-2gqwA:
undetectable		 5e5jB-2gqwA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ASP A 257
VAL A 264
LEU A 143
 DIO  A 402 ( 4.0A)
None
None
 0.67A 5e5jB-2hjsA:
undetectable		 5e5jB-2hjsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		3 ASP A 243
VAL A 270
LEU A 139
 None
 0.63A 5e5jB-2horA:
undetectable		 5e5jB-2horA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4d CRYPTOCHROME DASH

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ASP A 404
VAL A 491
LEU A 362
 None
 0.51A 5e5jB-2j4dA:
undetectable		 5e5jB-2j4dA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 ASP A 478
VAL A 469
LEU A 391
 None
 0.53A 5e5jB-2jisA:
undetectable		 5e5jB-2jisA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj4 ACETYLGLUTAMATE
KINASE

(Synechococcus
elongatus) 		PF00696
(AA_kinase) 		3 ASP A  97
VAL A 101
LEU A  78
 None
 0.66A 5e5jB-2jj4A:
undetectable		 5e5jB-2jj4A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpo PHEROMONE-BINDING
PROTEIN

(Antheraea
polyphemus) 		PF01395
(PBP_GOBP) 		3 ASP A 132
VAL A  62
LEU A 139
 None
 0.65A 5e5jB-2jpoA:
undetectable		 5e5jB-2jpoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2leo SERINE PROTEASE
INHIBITOR KAZAL-TYPE
7

(Homo sapiens) 		PF00050
(Kazal_1) 		3 ASP A  82
VAL A  30
LEU A  66
 None
 0.59A 5e5jB-2leoA:
undetectable		 5e5jB-2leoA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llh NUCLEOPHOSMIN

(Homo sapiens) 		PF16276
(NPM1-C) 		3 ASP A  22
VAL A  48
LEU A  63
 None
 0.65A 5e5jB-2llhA:
undetectable		 5e5jB-2llhA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps SYNTAXIN-6
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4

(Homo sapiens;
Mus musculus) 		PF00957
(Synaptobrevin)
no annotation 		3 ASP A  52
VAL A  57
LEU D 173
 None
 0.67A 5e5jB-2npsA:
undetectable		 5e5jB-2npsA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		3 ASP A 216
VAL A 332
LEU A 224
 None
 0.65A 5e5jB-2nqaA:
undetectable		 5e5jB-2nqaA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 ASP A 245
VAL A  21
LEU A 315
 None
 0.65A 5e5jB-2nqnA:
undetectable		 5e5jB-2nqnA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		3 ASP G 315
VAL G 319
LEU G 304
 None
 0.42A 5e5jB-2nzuG:
undetectable		 5e5jB-2nzuG:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00620
(RhoGAP) 		3 ASP A 471
VAL A 355
LEU A 351
 None
 0.66A 5e5jB-2ovjA:
undetectable		 5e5jB-2ovjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		3 ASP A  48
VAL A 184
LEU A  38
 None
 0.65A 5e5jB-2p4zA:
undetectable		 5e5jB-2p4zA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0f RNA URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		3 ASP A  44
VAL A  71
LEU A 101
 None
 0.63A 5e5jB-2q0fA:
undetectable		 5e5jB-2q0fA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		3 ASP A 146
VAL A 108
LEU A 104
 None
 0.62A 5e5jB-2qq1A:
undetectable		 5e5jB-2qq1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		3 ASP A 276
VAL A  30
LEU A 295
 None
 0.64A 5e5jB-2rfbA:
undetectable		 5e5jB-2rfbA:
16.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ASP A  29
VAL A  47
LEU A  76
 AB1  A 501 ( 3.3A)
AB1  A 501 ( 4.9A)
None
 0.25A 5e5jB-2rkfA:
21.0		 5e5jB-2rkfA:
84.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc2 INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF13517
(VCBS) 		3 ASP A 367
VAL A 391
LEU A   3
 CA  A2006 (-2.9A)
None
None
 0.68A 5e5jB-2vc2A:
undetectable		 5e5jB-2vc2A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		3 ASP A 238
VAL A 221
LEU A 204
 None
 0.65A 5e5jB-2vlcA:
undetectable		 5e5jB-2vlcA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ASP A 324
VAL A  55
LEU A 345
 None
 0.68A 5e5jB-2wgyA:
undetectable		 5e5jB-2wgyA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm4 PUTATIVE CYTOCHROME
P450 124

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ASP A 349
VAL A  78
LEU A 369
 None
 0.65A 5e5jB-2wm4A:
undetectable		 5e5jB-2wm4A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ASP A 311
VAL A  49
LEU A 331
 None
 0.61A 5e5jB-2xkrA:
undetectable		 5e5jB-2xkrA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 ASP A 414
VAL A 405
LEU A 436
 None
 0.55A 5e5jB-2xt6A:
undetectable		 5e5jB-2xt6A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 ASP A 336
VAL A 315
LEU A  89
 HO  A 402 (-3.6A)
None
None
 0.64A 5e5jB-2y9xA:
undetectable		 5e5jB-2y9xA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 ASP A 651
VAL A 646
LEU A 676
 None
 0.61A 5e5jB-2yfnA:
undetectable		 5e5jB-2yfnA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 ASP A 104
VAL A  85
LEU A  72
 None
 0.67A 5e5jB-2yxxA:
undetectable		 5e5jB-2yxxA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ASP A 390
VAL A 366
LEU A 362
 None
 0.65A 5e5jB-2z1qA:
undetectable		 5e5jB-2z1qA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		3 ASP A 215
VAL A 230
LEU A 226
 None
 0.68A 5e5jB-2z3tA:
undetectable		 5e5jB-2z3tA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 ASP A 169
VAL A 156
LEU A 154
 None
 0.58A 5e5jB-2z80A:
undetectable		 5e5jB-2z80A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA
NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		3 ASP A  30
VAL A  40
LEU B  35
 None
 0.63A 5e5jB-2zpbA:
undetectable		 5e5jB-2zpbA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3)
PF12041
(DELLA) 		3 ASP B  28
VAL A  22
LEU B  80
 None
 0.64A 5e5jB-2zsiB:
undetectable		 5e5jB-2zsiB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 426
VAL A 250
LEU A 255
 None
 0.60A 5e5jB-3aw5A:
undetectable		 5e5jB-3aw5A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azc CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Thermosynechococcus
elongatus) 		PF00355
(Rieske) 		3 ASP A  96
VAL A  93
LEU A  70
 None
 0.53A 5e5jB-3azcA:
undetectable		 5e5jB-3azcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcv PUTATIVE
GLYCOSYLTRANSFERASE
PROTEIN

(Bacteroides
fragilis) 		PF00535
(Glycos_transf_2) 		3 ASP A  95
VAL A  11
LEU A  27
 None
 0.66A 5e5jB-3bcvA:
undetectable		 5e5jB-3bcvA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ASP A 397
VAL A 409
LEU A 429
 None
 0.60A 5e5jB-3bgaA:
undetectable		 5e5jB-3bgaA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		3 ASP A 217
VAL A 181
LEU A 243
 None
 0.62A 5e5jB-3blwA:
undetectable		 5e5jB-3blwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY

(Geobacter
sulfurreducens) 		PF01435
(Peptidase_M48) 		3 ASP A  63
VAL A  60
LEU A  54
 None
 0.68A 5e5jB-3c37A:
undetectable		 5e5jB-3c37A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6r FLAVODOXIN

(Desulfovibrio
desulfuricans) 		PF00258
(Flavodoxin_1) 		3 ASP A  40
VAL A   7
LEU A  46
 None
 0.68A 5e5jB-3f6rA:
undetectable		 5e5jB-3f6rA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		3 ASP A  95
VAL A  25
LEU A  52
 None
 0.68A 5e5jB-3fiwA:
undetectable		 5e5jB-3fiwA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		3 ASP A  77
VAL A  51
LEU A 107
 None
 0.65A 5e5jB-3fvrA:
undetectable		 5e5jB-3fvrA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 ASP A 196
VAL A 192
LEU A 201
 None
 0.62A 5e5jB-3gbrA:
undetectable		 5e5jB-3gbrA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h07 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF00926
(DHBP_synthase) 		3 ASP A 204
VAL A  31
LEU A 160
 None
 0.67A 5e5jB-3h07A:
undetectable		 5e5jB-3h07A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		3 ASP A 213
VAL A   6
LEU A  25
 None
 0.60A 5e5jB-3h74A:
undetectable		 5e5jB-3h74A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn0 NITRATE TRANSPORT
PROTEIN

(Parabacteroides
distasonis) 		no annotation 3 ASP A 128
VAL A 167
LEU A 105
 None
 0.68A 5e5jB-3hn0A:
undetectable		 5e5jB-3hn0A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3idf USP-LIKE PROTEIN

(Wolinella
succinogenes) 		PF00582
(Usp) 		3 ASP A 125
VAL A  92
LEU A 115
 None
 0.59A 5e5jB-3idfA:
undetectable		 5e5jB-3idfA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Anaplasma
phagocytophilum) 		PF13561
(adh_short_C2) 		3 ASP A 226
VAL A 194
LEU A  23
 None
 0.43A 5e5jB-3k31A:
undetectable		 5e5jB-3k31A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3p D-ALANINE--D-ALANINE
LIGASE

(Streptococcus
mutans) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 ASP A 127
VAL A 134
LEU A 280
 None
 0.58A 5e5jB-3k3pA:
undetectable		 5e5jB-3k3pA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		3 ASP A  87
VAL A 103
LEU A  66
 None
 0.68A 5e5jB-3k6rA:
undetectable		 5e5jB-3k6rA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR

(Homo sapiens) 		PF13621
(Cupin_8) 		3 ASP A 161
VAL A 154
LEU A 150
 None
 0.62A 5e5jB-3kcxA:
undetectable		 5e5jB-3kcxA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A  85
VAL A 179
LEU A 106
 None
 0.65A 5e5jB-3kw8A:
undetectable		 5e5jB-3kw8A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3f PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		3 ASP X 415
VAL X 431
LEU X 402
 None
 0.57A 5e5jB-3l3fX:
undetectable		 5e5jB-3l3fX:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		3 ASP A  25
VAL A  58
LEU A  29
 None
 0.61A 5e5jB-3ldfA:
undetectable		 5e5jB-3ldfA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Salmonella
enterica) 		PF00926
(DHBP_synthase) 		3 ASP A 204
VAL A  31
LEU A 160
 None
 0.59A 5e5jB-3lquA:
undetectable		 5e5jB-3lquA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkh NITROALKANE OXIDASE

(Podospora
anserina) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		3 ASP A 271
VAL A 275
LEU A  75
 None
 0.66A 5e5jB-3mkhA:
undetectable		 5e5jB-3mkhA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		3 ASP A  63
VAL A 166
LEU A 172
 None
 0.68A 5e5jB-3mwtA:
undetectable		 5e5jB-3mwtA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nc3 CYTOCHROME P450 CYPX

(Bacillus
subtilis) 		PF00067
(p450) 		3 ASP A 314
VAL A  49
LEU A 344
 None
 0.55A 5e5jB-3nc3A:
undetectable		 5e5jB-3nc3A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkh INTEGRASE

(Staphylococcus
aureus) 		PF00589
(Phage_integrase) 		3 ASP A  57
VAL A 129
LEU A 106
 None
 0.36A 5e5jB-3nkhA:
undetectable		 5e5jB-3nkhA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 3 ASP A 379
VAL A 288
LEU A 394
 None
 0.49A 5e5jB-3nlcA:
undetectable		 5e5jB-3nlcA:
11.48