SIMILAR PATTERNS OF AMINO ACIDS FOR 5E4D_B_BEZB203

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 VAL A  24
ALA A  41
ILE A  45
THR A  44
 None
 1.18A 5e4dB-1gkrA:
0.0		 5e4dB-1gkrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		4 VAL A  80
ALA A 120
ILE A  95
THR A 118
 None
 1.15A 5e4dB-1hzoA:
0.0		 5e4dB-1hzoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iz1 LYSR-TYPE REGULATORY
PROTEIN

(Cupriavidus
necator) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 VAL A 189
ALA A 238
ILE A 219
THR A 192
 None
 1.10A 5e4dB-1iz1A:
0.6		 5e4dB-1iz1A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		4 VAL A 141
ALA A 123
ILE A 130
THR A 116
 None
 1.10A 5e4dB-1p9hA:
0.0		 5e4dB-1p9hA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		4 VAL A 223
ALA A 220
ILE A 350
THR A 351
 None
 1.13A 5e4dB-1tr1A:
0.0		 5e4dB-1tr1A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tua HYPOTHETICAL PROTEIN
APE0754

(Aeropyrum
pernix) 		PF00013
(KH_1) 		4 VAL A  57
ALA A  62
ILE A  54
THR A  34
 None
 1.01A 5e4dB-1tuaA:
1.7		 5e4dB-1tuaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlv ORNITHINE
CARBAMOYLTRANSFERASE

(Thermotoga
maritima) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 VAL A 156
ALA A 225
ILE A 268
THR A 267
 None
 1.06A 5e4dB-1vlvA:
0.0		 5e4dB-1vlvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv2 HYPOTHETICAL
PROTEIN, SIMILAR TO
ALPHA-ACETOLACTATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF03306
(AAL_decarboxy) 		4 VAL A 156
ALA A 111
ILE A  76
THR A  77
 None
 0.94A 5e4dB-1xv2A:
undetectable		 5e4dB-1xv2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		4 VAL A 208
ALA A 237
ILE A 193
THR A 196
 None
 1.12A 5e4dB-1ydwA:
0.0		 5e4dB-1ydwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 VAL A 829
ALA A 825
ILE A 813
THR A 814
 None
 0.96A 5e4dB-2bmbA:
undetectable		 5e4dB-2bmbA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		4 VAL A 227
ALA A 268
ILE A 886
THR A 887
 None
 1.14A 5e4dB-2btvA:
undetectable		 5e4dB-2btvA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		4 VAL A  29
ALA A 209
ILE A 315
THR A 314
 None
 1.12A 5e4dB-2dr1A:
undetectable		 5e4dB-2dr1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5

(Homo sapiens) 		PF01873
(eIF-5_eIF-2B) 		4 VAL A  44
ALA A  30
ILE A  82
THR A  41
 None
 1.08A 5e4dB-2e9hA:
undetectable		 5e4dB-2e9hA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5

(Homo sapiens) 		PF01873
(eIF-5_eIF-2B) 		4 VAL A  37
ALA A  23
ILE A  75
THR A  34
 None
 0.85A 5e4dB-2g2kA:
undetectable		 5e4dB-2g2kA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1r DIMETHYLADENOSINE
TRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00398
(RrnaAD) 		4 VAL A 131
ALA A 129
ILE A 141
THR A 140
 None
 1.15A 5e4dB-2h1rA:
undetectable		 5e4dB-2h1rA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hae MALATE
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF00390
(malic)
PF03949
(Malic_M) 		4 VAL A 372
ALA A 376
ILE A 332
THR A 333
 None
 1.02A 5e4dB-2haeA:
undetectable		 5e4dB-2haeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		4 VAL A 116
ALA A 107
ILE A   8
THR A   9
 None
 1.06A 5e4dB-2hi1A:
undetectable		 5e4dB-2hi1A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		4 VAL A  72
ALA A  81
ILE A  14
THR A  36
 None
 1.17A 5e4dB-2i5gA:
undetectable		 5e4dB-2i5gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		4 VAL A 343
ALA A  98
ILE A 300
THR A 327
 None
 1.02A 5e4dB-2iq1A:
undetectable		 5e4dB-2iq1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5u MREC PROTEIN

(Listeria
monocytogenes) 		PF04085
(MreC) 		4 VAL A 171
ALA A 150
ILE A 158
THR A 152
 None
 1.18A 5e4dB-2j5uA:
undetectable		 5e4dB-2j5uA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kco 30S RIBOSOMAL
PROTEIN S8E

(Sulfolobus
solfataricus) 		PF01201
(Ribosomal_S8e) 		4 VAL A 111
ALA A 109
ILE A  78
THR A 104
 None
 1.21A 5e4dB-2kcoA:
undetectable		 5e4dB-2kcoA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nd4 AMYLASE-BINDING
PROTEIN ABPA

(Streptococcus
parasanguinis) 		no annotation 4 VAL A 169
ALA A 181
ILE A 141
THR A 145
 None
 1.18A 5e4dB-2nd4A:
undetectable		 5e4dB-2nd4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 VAL A 230
ALA A 157
ILE A 205
THR A 182
 None
 1.12A 5e4dB-2obvA:
undetectable		 5e4dB-2obvA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qx2 SEX PHEROMONE
STAPH-CAM373

(Staphylococcus
aureus) 		PF07537
(CamS) 		4 VAL A 394
ALA A 381
ILE A 349
THR A 348
 None
 1.00A 5e4dB-2qx2A:
undetectable		 5e4dB-2qx2A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcu PROTEIN FUCU HOMOLOG

(Mus musculus) 		PF05025
(RbsD_FucU) 		4 VAL A  29
ALA A 131
ILE A  40
THR A  37
 None
 0.99A 5e4dB-2wcuA:
undetectable		 5e4dB-2wcuA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 VAL A 103
ALA A 105
ILE A 286
THR A 285
 None
 1.15A 5e4dB-2yzmA:
undetectable		 5e4dB-2yzmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CP43
PROTEIN
PHOTOSYSTEM II D2
PROTEIN

(Thermosynechococcus
vulcanus;
Thermosynechococcus
vulcanus) 		PF00421
(PSII)
PF00124
(Photo_RC) 		4 VAL C 466
ALA D 249
ILE C 459
THR D 221
 None
PQ9  D1042 (-3.2A)
None
None
 1.07A 5e4dB-3a0hC:
undetectable		 5e4dB-3a0hC:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		4 VAL A 263
ALA A 260
ILE A 405
THR A 406
 None
 1.11A 5e4dB-3aivA:
undetectable		 5e4dB-3aivA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 VAL A 119
ALA A  65
ILE A  91
THR A  88
 None
 1.17A 5e4dB-3b4tA:
undetectable		 5e4dB-3b4tA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c24 PUTATIVE
OXIDOREDUCTASE

(Jannaschia sp.
CCS1) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		4 VAL A  71
ALA A  18
ILE A  30
THR A  27
 None
 0.93A 5e4dB-3c24A:
undetectable		 5e4dB-3c24A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		4 VAL A 151
ALA A 121
ILE A 118
THR A 119
 None
 1.08A 5e4dB-3d0cA:
undetectable		 5e4dB-3d0cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8x THIOREDOXIN
REDUCTASE 1

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 VAL A 257
ALA A 253
ILE A   9
THR A 119
 None
FAD  A1001 ( 4.4A)
FAD  A1001 (-4.7A)
FAD  A1001 (-3.9A)
 1.19A 5e4dB-3d8xA:
undetectable		 5e4dB-3d8xA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF02522
(Antibiotic_NAT) 		4 VAL A 123
ALA A 140
ILE A  65
THR A  64
 None
 1.14A 5e4dB-3e4fA:
undetectable		 5e4dB-3e4fA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7m ALKALINE SERINE
PROTEASE VER112

(Lecanicillium
psalliotae) 		PF00082
(Peptidase_S8) 		4 VAL A 303
ALA A 262
ILE A 334
THR A 331
 None
 0.95A 5e4dB-3f7mA:
undetectable		 5e4dB-3f7mA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum) 		PF00082
(Peptidase_S8) 		4 VAL A 202
ALA A 161
ILE A 233
THR A 230
 None
 0.90A 5e4dB-3f7oA:
undetectable		 5e4dB-3f7oA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpr RHODOCETIN SUBUNIT
GAMMA

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		4 VAL C3068
ALA C3054
ILE C3061
THR C3058
 None
 1.20A 5e4dB-3gprC:
undetectable		 5e4dB-3gprC:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Escherichia
coli;
Dermatophagoides
pteronyssinus) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		4 VAL A 110
ALA A 112
ILE A 317
THR A 320
 None
 1.17A 5e4dB-3h4zA:
undetectable		 5e4dB-3h4zA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		4 VAL A 204
ALA A 259
ILE A 263
THR A 262
 None
 1.17A 5e4dB-3h8lA:
undetectable		 5e4dB-3h8lA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxj PYRROLO-QUINOLINE
QUINONE

(Methanococcus
maripaludis) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13570
(PQQ_3) 		4 VAL A 230
ALA A 239
ILE A 222
THR A 227
 None
 1.02A 5e4dB-3hxjA:
undetectable		 5e4dB-3hxjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibh SACCHAROMYCES
CEREVISIAE GTT2

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 VAL A 176
ALA A 120
ILE A 186
THR A 187
 None
 1.19A 5e4dB-3ibhA:
undetectable		 5e4dB-3ibhA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		4 VAL A 103
ALA A 110
ILE A 446
THR A 113
 None
 1.17A 5e4dB-3khzA:
2.6		 5e4dB-3khzA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 VAL A-234
ALA A-232
ILE A -27
THR A -24
 None
 1.17A 5e4dB-3l2jA:
undetectable		 5e4dB-3l2jA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		4 VAL A  88
ALA A  62
ILE A  97
THR A  69
 None
 1.08A 5e4dB-3l6dA:
undetectable		 5e4dB-3l6dA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Listeria
innocua) 		PF02082
(Rrf2) 		4 VAL A  55
ALA A  52
ILE A  79
THR A  82
 None
 0.90A 5e4dB-3lwfA:
undetectable		 5e4dB-3lwfA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oix PUTATIVE
DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
OXIDASE

(Streptococcus
mutans) 		PF01180
(DHO_dh) 		4 VAL A  43
ALA A  20
ILE A 245
THR A 247
 None
FMN  A 400 (-3.1A)
None
FMN  A 400 (-4.0A)
 1.16A 5e4dB-3oixA:
undetectable		 5e4dB-3oixA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p42 PREDICTED PROTEIN

(Escherichia
coli) 		PF06251
(Caps_synth_GfcC) 		4 VAL A 226
ALA A 181
ILE A 100
THR A  99
 None
 1.05A 5e4dB-3p42A:
undetectable		 5e4dB-3p42A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		4 VAL A 268
ALA A 264
ILE A  73
THR A  70
 None
 1.06A 5e4dB-3pgyA:
undetectable		 5e4dB-3pgyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 VAL A 224
ALA A 267
ILE A 114
THR A 112
 None
 1.10A 5e4dB-3ruyA:
undetectable		 5e4dB-3ruyA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 VAL A 227
ALA A 157
ILE A 201
THR A 182
 None
 1.19A 5e4dB-3rv2A:
undetectable		 5e4dB-3rv2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqb TYPE-1 FIMBRIAL
PROTEIN, A CHAIN

(Escherichia
coli) 		PF00419
(Fimbrial) 		4 VAL B 156
ALA B  66
ILE B 131
THR B 122
 None
 1.15A 5e4dB-3sqbB:
undetectable		 5e4dB-3sqbB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 VAL A 811
ALA A 771
ILE A 711
THR A 712
 None
 1.06A 5e4dB-3tsyA:
undetectable		 5e4dB-3tsyA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		4 VAL A 110
ALA A 112
ILE A 317
THR A 320
 None
 1.20A 5e4dB-4b3nA:
undetectable		 5e4dB-4b3nA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 VAL A  80
ALA A 120
ILE A  95
THR A 118
 None
 1.16A 5e4dB-4c75A:
undetectable		 5e4dB-4c75A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		4 VAL A 301
ALA A 319
ILE A 285
THR A 284
 None
 1.07A 5e4dB-4cjaA:
undetectable		 5e4dB-4cjaA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		4 VAL A 343
ALA A  98
ILE A 300
THR A 327
 None
 1.03A 5e4dB-4da1A:
undetectable		 5e4dB-4da1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e74 PLEXIN-A4

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 VAL A1589
ALA A1585
ILE A1525
THR A1583
 None
 1.09A 5e4dB-4e74A:
undetectable		 5e4dB-4e74A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 VAL A 274
ALA A 270
ILE A 318
THR A 304
 None
 1.13A 5e4dB-4egeA:
undetectable		 5e4dB-4egeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462

(Clostridium
acetobutylicum) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 VAL A 181
ALA A 184
ILE A 240
THR A 239
 None
 1.20A 5e4dB-4eufA:
undetectable		 5e4dB-4eufA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gg2 GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 HEAVY
CHAIN

(Homo sapiens) 		PF01019
(G_glu_transpept) 		4 VAL A 248
ALA A 250
ILE A 237
THR A 234
 None
NAG  A 403 ( 4.4A)
None
NAG  A 403 (-3.4A)
 1.11A 5e4dB-4gg2A:
undetectable		 5e4dB-4gg2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		4 VAL A  31
ALA A  57
ILE A  13
THR A  28
 None
 1.14A 5e4dB-4kemA:
undetectable		 5e4dB-4kemA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n80 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 VAL A 267
ALA A 272
ILE A 276
THR A 274
 None
 1.12A 5e4dB-4n80A:
undetectable		 5e4dB-4n80A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		4 VAL A 125
ALA A  91
ILE A 101
THR A  76
 None
 0.99A 5e4dB-4nq1A:
undetectable		 5e4dB-4nq1A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qid BACTERIORHODOPSIN-I

(Haloquadratum
walsbyi) 		PF01036
(Bac_rhodopsin) 		4 VAL A 218
ALA A 223
ILE A 192
THR A 189
 None
RET  A 301 (-3.6A)
None
None
 1.01A 5e4dB-4qidA:
undetectable		 5e4dB-4qidA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		4 VAL A 111
ALA A 113
ILE A 318
THR A 321
 None
 1.20A 5e4dB-4qvhA:
undetectable		 5e4dB-4qvhA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 VAL A  73
ALA A  68
ILE A 105
THR A 104
 None
 1.17A 5e4dB-4s0vA:
undetectable		 5e4dB-4s0vA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 VAL A 338
ALA A 331
ILE A 364
THR A 363
 None
 0.91A 5e4dB-4wz9A:
undetectable		 5e4dB-4wz9A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		4 VAL A 110
ALA A 112
ILE A 317
THR A 320
 None
 1.19A 5e4dB-4xa2A:
undetectable		 5e4dB-4xa2A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 VAL A 112
ALA A 114
ILE A 319
THR A 322
 None
 1.20A 5e4dB-4xaiA:
undetectable		 5e4dB-4xaiA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL A   4
ALA A 244
ILE A   6
THR A   7
 None
 1.08A 5e4dB-4xoxA:
undetectable		 5e4dB-4xoxA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 VAL A 230
ALA A 157
ILE A 205
THR A 182
 None
 1.12A 5e4dB-5a1iA:
undetectable		 5e4dB-5a1iA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 VAL A 276
ALA A 234
ILE A 279
THR A 202
 None
 1.20A 5e4dB-5ddsA:
undetectable		 5e4dB-5ddsA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		4 VAL A 259
ALA A 322
ILE A 283
THR A 285
 None
 1.07A 5e4dB-5fg3A:
undetectable		 5e4dB-5fg3A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		4 VAL A-262
ALA A-260
ILE A -55
THR A -52
 None
 1.12A 5e4dB-5fsgA:
undetectable		 5e4dB-5fsgA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Escherichia
coli;
Danio rerio) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 VAL A 111
ALA A 113
ILE A 318
THR A 321
 None
 1.21A 5e4dB-5gppA:
undetectable		 5e4dB-5gppA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 4 VAL A1017
ALA A 944
ILE A 996
THR A 995
 None
 1.10A 5e4dB-5hdtA:
undetectable		 5e4dB-5hdtA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 VAL A  43
ALA A 464
ILE A 251
THR A 462
 None
 1.10A 5e4dB-5hvmA:
undetectable		 5e4dB-5hvmA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Myxococcus
xanthus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 VAL A  30
ALA A  33
ILE A  21
THR A  36
 None
CAA  A 501 (-3.5A)
None
None
 1.05A 5e4dB-5hwqA:
undetectable		 5e4dB-5hwqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j48 CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 VAL A 320
ALA A 323
ILE A 276
THR A 280
 6FW  A 404 ( 4.6A)
None
None
None
 1.20A 5e4dB-5j48A:
undetectable		 5e4dB-5j48A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		4 VAL A 351
ALA A 353
ILE A 340
THR A 337
 None
 1.01A 5e4dB-5jayA:
1.3		 5e4dB-5jayA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S8E

(Pyrococcus
abyssi) 		PF01201
(Ribosomal_S8e) 		4 VAL J 110
ALA J 108
ILE J  77
THR J 103
 None
 1.14A 5e4dB-5jb3J:
undetectable		 5e4dB-5jb3J:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Escherichia
coli;
Mus musculus) 		PF00027
(cNMP_binding)
PF13416
(SBP_bac_8) 		4 VAL A-259
ALA A-257
ILE A -52
THR A -49
 None
 1.18A 5e4dB-5jonA:
undetectable		 5e4dB-5jonA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 4 VAL A 990
ALA A1271
ILE A 917
THR A 918
 None
 1.04A 5e4dB-5kk5A:
undetectable		 5e4dB-5kk5A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 VAL A 215
ALA A 286
ILE A 252
THR A 278
 None
 1.19A 5e4dB-5lkdA:
undetectable		 5e4dB-5lkdA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 VAL A 212
ALA A 237
ILE A 240
THR A  44
 None
 1.12A 5e4dB-5lu4A:
undetectable		 5e4dB-5lu4A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH

(Staphylococcus
capitis) 		PF01566
(Nramp) 		4 VAL A 390
ALA A 223
ILE A 216
THR A  55
 None
MN  A 501 (-3.9A)
None
None
 1.16A 5e4dB-5m95A:
undetectable		 5e4dB-5m95A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03147
(FDX-ACB) 		4 VAL A 394
ALA A 326
ILE A 380
THR A 381
 None
 1.09A 5e4dB-5mgvA:
4.0		 5e4dB-5mgvA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 VAL A 887
ALA A 663
ILE A1029
THR A1028
 None
 1.18A 5e4dB-5mqmA:
undetectable		 5e4dB-5mqmA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 4 VAL A 307
ALA A 312
ILE A 326
THR A 328
 None
 1.18A 5e4dB-5n4cA:
undetectable		 5e4dB-5n4cA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 VAL A 509
ALA A 485
ILE A 416
THR A 439
 None
 1.16A 5e4dB-5nd5A:
undetectable		 5e4dB-5nd5A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omt NUCB

(Bacillus
licheniformis) 		no annotation 4 VAL A 124
ALA A 120
ILE A  54
THR A  50
 None
 1.09A 5e4dB-5omtA:
undetectable		 5e4dB-5omtA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 VAL A 111
ALA A 113
ILE A 318
THR A 321
 None
 1.20A 5e4dB-5osqA:
undetectable		 5e4dB-5osqA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szr PROTEIN PCDHGB2

(Mus musculus) 		PF00028
(Cadherin) 		4 VAL A 406
ALA A 394
ILE A 318
THR A 341
 None
 1.16A 5e4dB-5szrA:
undetectable		 5e4dB-5szrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9t PROTOCADHERIN GAMMA
B2-ALPHA C

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 VAL A 406
ALA A 394
ILE A 318
THR A 341
 None
 1.08A 5e4dB-5t9tA:
undetectable		 5e4dB-5t9tA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2w SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 VAL A  78
ALA A  74
ILE A  35
THR A  36
 None
 1.11A 5e4dB-5u2wA:
undetectable		 5e4dB-5u2wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 4 VAL A 112
ALA A 114
ILE A 319
THR A 322
 None
 1.20A 5e4dB-5v6yA:
undetectable		 5e4dB-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens;
Homo sapiens) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2)
PF13927
(Ig_3) 		4 VAL C  79
ALA C  92
ILE A 458
THR A 457
 None
 1.17A 5e4dB-5vxzC:
undetectable		 5e4dB-5vxzC:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		no annotation 4 VAL A 259
ALA A 322
ILE A 283
THR A 285
 None
 1.10A 5e4dB-5yt0A:
undetectable		 5e4dB-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 VAL A 221
ALA A 274
ILE A 300
THR A 299
 None
 1.18A 5e4dB-6aphA:
undetectable		 5e4dB-6aphA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvg PROTEIN-N(PI)-PHOSPH
OHISTIDINE-SUGAR
PHOSPHOTRANSFERASE
(ENZYME II OF THE
PHOSPHOTRANSFERASE
SYSTEM) (PTS SYSTEM
GLUCOSE-SPECIFIC
IIBC COMPONENT)

(Bacillus cereus) 		no annotation 4 VAL A 104
ALA A 138
ILE A 101
THR A  98
 None
 1.15A 5e4dB-6bvgA:
undetectable		 5e4dB-6bvgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 VAL A-105
ALA A-103
ILE A 102
THR A 105
 6AK  A 403 ( 4.9A)
None
None
None
 1.16A 5e4dB-6dm8A:
undetectable		 5e4dB-6dm8A:
undetectable